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Maimaiti Yisireyili, MD, PhD
Medical Doctor, Research Institute of General and Minimally Invasive Surgery
  • People’s Hospital of Xinjiang Uygur Autonomous Region
    Urumqi, Xinjiang, P.R. China
    Phone: +86 991 8563 908
    Email: maimaiti727@sina.com

Education

DEGREE DEPARTMENT UNIVERSITY YEAR
PhD Department of Cardiology Nagoya University Graduate School of Medicine, Nagoya, Japan 2014-2017
MSc Department of Advanced Medicine for Uremia Nagoya University Graduate School of Medicine, Nagoya, Japan 2012-2014
BSc Clinical Medicine Xinjiang Medical University, Urumqi, China 2006-2011

Biography

Dr. Maimaiti earned his BSc in Clinical Medicine at Xinjiang Medical University. He Completed his Masters and PhD in Cardiovascular Medicine at Nagoya University Graduate School of Medicine, Nagoya, Japan. He is now working as Medical Doctor and Assistant at Research Institute of General and Minimally Invasive Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, P.R. China. His specialized research fields includes: Cardiovascular Diseases (CVD); Chronic Kidney Diseases (CKD); Uremic Toxins; Gastroesophageal Reflux Diseases (GERD) & Gastrointestinal Disorders; Metabolic Syndromes (Obesity, Diabetes and Stress Related Disorders).

Research Interest

  • Cardiovascular Diseases (CVD)
  • Chronic Kidney Diseases (CKD), Uremic Toxins
  • Gastroesophageal Reflux Diseases (GERD) & Gastrointestinal Disorders
  • Metabolic Syndromes (Obesity, Diabetes and Stress Related Disorders)

Scientific Activities

Working Experience
2017-Present Medical Doctor & Assistant, Research Institute of General and Minimally Invasive Surgery,
People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, P.R. China
2011- 2012 Medical Intern, Practical Work at Bei Jing Liang Er Kang Dermatology Hospital, Urumqi, China
Competence and Skills
  1. Molecular biology and biochemistry
  • RNA isolation and purification (in vitro or in vivo), RNA reverse transcription
  • Plasmid purification (QIAGEN kit)
  • Standard PCR and RT-PCR
  • SDS-PAGE, Western blot
  1. Immunology
  • ELISA and ELISA array
  • Immunohistochemical stain
  • TUNEL, Elastin Von-kossa, Masson’s trichrome, Picrosirius red and HE stains
  1. Cell Biology
  • siRNA (gene knockout) techniques
  • Fluorescent microscopy
  • Cell proliferation, migration and invasion assay
  • Cell culture and passage
  1. Animal techniques and experimental models
  • Mouse handling, anesthesia, IP injection, IV injection, peritoneal lavage, blood withdrawal
  • Mouse & Rat disease model: 5/6 nephroctemized mice (chronic kidney diseases model); Hypertension rat model; Uremic toxin rat model; Restraint stress model; Obesity mice model. GERD and Herina Rat model
Honors and Awards
  • Honored by the Natural Science Foundation of Xinjiang Autonomous Region (Jan 2018-Dec 2020)
  • Honored by the Doctoral Initiation Fund of People’s Hospital of Xinjiang Uygur Autonomous Region (Aug 2017-Jul 2019)
  • Honored by the Japan Society for Promotion of Science (JSPS) Research Fellowship (DC1) for Young Scientists (Apr 2015-Mar 2017)
  • Awarded by the Ajinomoto Scholarship Foundation for Overseas Students, Japan (Apr 2013-Mar 2015)
  • Honored by the Research Grant from Kidney Foundation, Japan (Aug 2012-Mar 2013)

Publications

  1. Yisireyili M, Wulamu W, Aili A, et al. Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model. Exp Ther Med. 2019 Aug; 18(2): 1375-1383 (IF=1.448).
  2. Aizezi M, Mahemuti A, Yisireyili M, Zhang W, Alimujiang A, et al. (2019) Serum Uric Acid Levels Mediated Atrial Fibrillation in Patients with Hypertension. J Clin Case Stu 4 (2): dx.doi.org/10.16966/2471-4925.188 (IF: 0.742).
  3. Aizezi M, Yisireyili M, Zhang W, Alimujiang A, Zhang H, et al. (2019) Analysis of the Clinical Effects and Expression Levels of Inflammatory Cytokines in Type B AD Patients after TEVAR Therapy. J Clin Case Stu 4 (2): doi.org/10.16966/2471-4925.187. (IF: 0.742).
  4. Wulamu W, Yisireyili M, Aili A, Takeshita K, Alimujiang A, et al. Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and protease- activated receptor 2 in a murine model. Mol Med Rep. 2019 Jun; 19 (6): 5386-5396 (IF: 1.92).
  5. Zhang WM, Chang DQ, Huang JJ, Maimaitiaili A, Ermek T, Yisireyili M, et al. Double-chambered left ventricle: A rare case in a child. Echocardiography. 2019 Jan; 36(1): 192-195 (IF: 1.117).
  6. Yisireyili M, Takeshita K, Saito S, Murohara T, Niwa T. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Nagoya J Med Sci 2017 Nov; 79(4): 477-486 (IF: 1.016).
  7. Yisireyili M, Uchida Y, Yamamoto K, Nakayama T, Cheng XW, et al. Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice. Brain Behav Immun 2018 Mar; 69: 167-179 (IF: 5.889).
  8. Lei Y, Yang G, Hu L, Piao L, Inoue A, Jiang H, Sasaki T, Zhao G, Yisireyili M, et al. Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress. Int J Cardiol 2017 Sep 15; 243: 413-420 (IF: 6.175).
  9. Yisireyili M, Hayashi M, Wu H, Uchida Y, Yamamoto K, et al. Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice. Sci Rep 2017 Apr 28; 7(1): 1266 (IF: 4.23).
  10. Yisireyili M, Takeshita K, Hayashi M, Wu H, Uchida Y, et al. Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model. Psycho neuroendocrinology 2016 Nov; 73: 186-195 (IF: 4.731).
  11. Wu H, Cheng XW, Hu L, Takeshita K, Hu C, Du Q, Li X, Zhu E, Huang Z, Yisireyili M, et al. Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway. Arterioscler Thromb Vasc Biol 2016 Aug; 36(8): 1549-1557 (IF: 6.086).
  12. Ng HY, Bolati W, Lee CT, Chien YS, Yisireyili M, et al. Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells. Nephron 2016; 133(3): 205-212 (IF: 2.55).
  13. Yisireyili M, Saito S, Abudureyimu S, Adelibieke Y, Ng Hwee, Nishijima F, Takeshita K, Murohara T, Niwa T. Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells. PLoS One 2014 Oct 24; 9(10): e109268 (IF: 3.23).
  14. Saito S, Yisireyili M, Shimizu H, Ng HY, Niwa T. Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells. J Ren Nutr. 2015 Mar; 25(2): 145-148 (IF: 1.89).
  15. Saito S, Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of transforming growth factor-ß1 and <alpha>-smooth muscle actin in proximal tubular cells. Endocrinology 2014 May; 155(5): 1899-907 (IF: 4.50).
  16. Adelibieke Y, Yisireyili M, Ng Hwee, Saito S, Nishijima F, Niwa T. Indoxyl Sulfate Induces IL-6 Expression in Vascular Endothelial and Smooth Muscle Cells through OAT3/AhR/NF-κB Pathway. Nephron Exp Nephrol 2014; 128(1-2): 1-8 (IF: 2.56).
  17. Ng Hwee, Yisireyili M, Saito S, Chien Lee, Adelibieke Y, Nishijima F, T Niwa. Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells. PLoS One 2014 Mar 10; 9(3): e91517 (IF: 3.23).
  18. Yisireyili M, Shimizu H, Saito S, Enomoto A, Nishijima F, Niwa T. Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats. Life Sci 10 July 2013, 1180-1185 (IF: 2.73).
  19. Bolati D, Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB. BMC Nephrol 2013; 14: 56 (IF: 1.69).
  20. Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am J Nephrol 2013; 37(2): 97-103 (IF: 2.56).
  21. Shimizu H, Yisireyili M, Higashiyama Y, Nishijima F, Niwa T. Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells. Life Sci 2013; 92 (2): 143-148 (IF: 2.73).
  22. Shimizu H, Yisireyili M, Nishijima F, Niwa T. Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence. Am J Nephrol 2012; 36(2): 184-189 (IF: 2.56).

 

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