Alfonso Eirin Massat, MD
Assistant Professor of Nephrology & Hypertension
  • Mayo Clinic College of Medicine
    USA
    Phone: 507-538-9941
  • Email: EirinMassat.Alfonso@mayo.edu

Education

  • Liceo N 35 Instituto Alfredo Vazquez Acevedo” IAVA. (Montevideo, Uruguay). B Sc, (Option: Medicine)1992 - 1995
  • School of Medicine University of the Republic. (Montevideo, Uruguay)   1996 - 2004
  • OBGYN unit - Military Hospital (Montevideo, Uruguay) Surgical Internship   2004 – 2005

 

Biography

I am an Assistant Professor of Medicine currently working at Mayo Clinic in Rochester, Minnesota. I graduated the School of Medicine at the University of the Republic, Montevideo, Uruguay in 2004. I was involved in clinical practice in Montevideo until December of 2008, when my interest in research drove me to the Mayo Clinic to work as a Research Trainee, Research Fellow, and Senior Research Fellow in the Division of Nephrology and Hypertension.
Over the past years, I have published more than 40 peer-reviewed papers and more than 60 abstracts in prestigious scientific journals in the field of renal and cardiovascular diseases, 3 book chapters, and served as a reviewer for several peer-reviewed journals with a worldwide circulation, such as Hypertension and Circulation. I have also presented multiple oral and poster presentations at recognized scientific meetings such as the American Society of Nephrology Renal Week, which is the world’s premier nephrology meeting.

I have received several awards including a 2-years postdoctoral fellowship from the American Heart Association (2010-2012), the “Outstanding Research Fellow Award 2012” from the Department of Medicine at Mayo Clinic, a Training & Career Development Award from the Center for Regenerative Medicine at Mayo Clinic, a “Top Oral Abstract by Trainees for the ASN Kidney Week 2012”, the “Top Scoring abstract in all 16 American Heart Association’s Specialty Conferences 2012”.

Research Interest

My research interests have focused on understanding the pathogenesis of renal and cardiac injury due to atherosclerotic renovascular disease (ARVD), and the development of novel treatment strategies to improve blood pressure and renal outcomes after revascularization in swine ARVD. These studies include the application of state-of-the-art imaging techniques (multi-detector computer tomography, micro-computer tomography, magnetic resonance imaging, etc.) in animal models and in humans. In addition, I have been involved in several projects aimed to elucidate the deleterious effects of inflammation in the ARVD kidney, and the development of treatment options (stem cells, progenitor cells, anti-apoptotic drugs, etc.) to attenuate microvascular rarefaction and loss beyond the stenotic lesion.

Professional Activities:

Present Academic Rank and Position

  • Assistant Professor of Medicine - College of Medicine, Mayo Clinic 2012-Present
  • Associate Consultant - I - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 2015- Present

Honors / Awards:

  • Post-doctoral Fellowship Award - American Heart Association - 07/2011
  • Outstanding Research Fellow Award - Department of Medicine, Mayo Clinic - 07/2012
  • Top Scoring Abstract: Best of AHA Specialty Conferences: Best of HBPR03 (“Increased Circulating Inflammatory Endothelial Cells (IEC) in African-American vs. Caucasians with Essential Hypertension” Hypertension 2012;60:a66-a66) - 08/2012
  • Top Oral Abstract: ASN Renal Week (“Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes after Revascularization in Experimental Atherosclerotic Renal Artery Stenosis” J Am Soc Nephrol Abstracts Issue 23: 2012 (80A-81A). - 10/2012
  • Cover of Hypertension: ”A Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes After Revascularization in Experimental Atherosclerotic Renal Artery Stenosis” - 11/2012
  • Training & Career Development Award - Center for Regenerative Medicine, Mayo Clinic - 12/2013
  • Nephrology Dialysis Transplantation Editor's choice: “Renal vein cytokine release as an index of renal parenchymal inflammation in chronic experimental renal artery stenosis” - 02/2014
  • Travel Award – ASN Renal Week “Advances in Research Conference” -08/2014

Previous Professional Positions and Major Appointments

  • Research Fellow Division of Nephrology and Hypertension. Renovascular Research Laboratory PI: L. O. Lerman, MD, PhD. Mayo Clinic (Rochester, MN). - 2010 – 2011
  • Research Trainee Division of Nephrology and Hypertension. PI: F. C. Fervenza, MD, PhD. Mayo Clinic (Rochester, MN). - 2008 – 2009

Professional & Community Memberships, Societies and Services

  • Professional Memberships & Services
  • American Society of Nephrology Member -2009
  • Renal Physicians Association Member - 2012
  • American Physiological Society Member - 2012
  • Sigma Xi Member - 2012

 

Publications

Peer-Reviewed articles

  1. Leung N, Eirin A, Irazabal MV, Maddox DE, Gunderson HD, Fervenza FC, Garovic VD. Acute kidney injury in patients with inactive cytochrome P450 polymorphisms. Ren Fail. 2009;31(8):749-52.
  2. Fervenza FC, Abraham RS, Erickson SB, Irazabal MV, Eirin A, Specks U, Nachman PH, Bergstralh EJ, Leung N, Cosio FG, Hogan MC, Dillon JJ, Hickson LJ, Li X, Cattran DC. Rituximab Therapy in Idiopathic Membranous Nephropathy: A 2-Year Study. Clin J Am Soc Nephrol. 2010;5(12):2188-2198.
  3. Eirin A, Zhu XY, Urbieta-Caceres VH, Grande JP, Lerman A, Textor SC, Lerman LO. Persistent renal dysfunction after revascularization is associated with outer cortical microvascular remodeling in swine atherosclerotic renal artery stenosis. Am J Physiol Renal Physiol. 2011;300(6):F1394-401.
  4. Geetha D, Eirin A, True K, Irazabal MV, Specks U, Seo P, Nachman PH, Fervenza FC. Renal Transplantation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Multicenter Experience. Transplantation. 2011;27;91(12):1370-1375.
  5. Herzenberg AM, Fogo AB, Reich HN, Troyanov S, Bavbek N, Eirin A, Hunley TE, Hladunewich MA, Julian BA, Fervenza FC, Cattran DC. Validation of the Oxford classification of IgA nephropathy. Kidney Int. 2011;80(3):310-7.
  6. Eirin A, Irazabal MV, Gertz MA, Dispenzieri A, Lacy MQ, Buadi FK, Kumar S, Sethi S, Kyle RA, Hayman SR, Zeldenrust SR, Greipp PR, Fervenza FC, Ramirez-Alvarado M, Leung N. Clinical Features of Patients with Immunoglobulin Light Chain Amyloidosis (AL) with Vascular Limited Deposition in the Kidney. Nephrol Dial Transplant. 2011;0: 1-4.
  7. Irazabal MV, Eirin A, Gertz MA, Dispenzieri A, Kumar S , Buadi F, Lacy MQ, Hayman SR, Dingli D, Hogan WJ, Gastineau DA, Glavey SV, Amer H, N Leung. Acute kidney injury is common during leukocyte engraftment after autologous stem cell transplantation in patients with light chain amyloidosis (AL). Am J Hematol 2011;87(1):51-4.
  8. Zacharias DG, Kim SG, Eirin A, Bachar AR, Oh YK, Herrmann J, Rodriguez-Porcel M, Cohen P, Lerman LO, Lerman A. Humanin, a cytoprotective peptide, is expressed in carotid artherosclerotic plaques in humans. PLoS ONE 2012;7(2): e31065.
  9. Eirin A, Zhu XY, Krier JD, Tang H, Jordan KL, Grande JP, Lerman A, Textor SC, Lerman LO. Adipose tissue-derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis. Stem Cells. 2012;30(5):1030-41.
  10. Ebrahimi B, Li Z, Eirin A, Zhu XY, Textor SC, Lerman LO. Addition of Endothelial Progenitor Cells to Renal Revascularization Restores Medullary Tubular Oxygen Consumption in Swine Renal Artery Stenosis. Am J Physiol Renal Physiol. 2012;302(1):F1478-85.
  11. Eirin A, Gloviczki ML, Gossl M, Tang H, Jordan KL, Woollard JR, Lerman A, Grande JP, Textor SC, Lerman LO. Inflammatory and injury signals released from the post-stenotic human kidney. Eur Heart J 2013 34(7):540-8.
  12. Zhang X, Urbieta-Caceres VH, Eirin A, Bell CC, Crane JA, Tange H, Jordan K, Oh YK, Zhu, XY, Korsmo MJ, Bachar AR, Cohen P, Lerman A, Lerman LO. Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Life Sciences 2012;4;91(5-6):199-206.
  13. Eirin A, Gloviczki ML, Tang H, Woollard JR, Lerman A, Textor SC, Lerman LO. Chronic renovascular hypertension is associated with elevated plasma levels of neutrophil gelatinase-associated lipocalin. Nephrol Dial Transplant 2012;27(11):4153-61.
  14. Irazabal MV, Eirin A, Lieske J, Beck LH, Borland TM, Dillon JJ, Nachman PH, Sethi S, Nasr S, Erickson SB, Cattran DC, and Fervenza FC. Low and high molecular weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: A prospective study. Nephrol Dial Transplant 2012;5(5):720-8.
  15. Leung N, Gertz M, Kyle RA, Fervenza FC, Irazabal MV, Eirin A, Kumar S, Cha SS, Rajkumar SV, Lacy MQ, Zeldenrust SR, Buadi FK, Hayman SR, Nasr SH, Sethi S, Ramirez-Alvarado M, Witzig TE, Herrmann SM, Dispenzieri A. Urinary Albumin Excretion Patterns of Patients with Cast Nephropathy and Other Monoclonal Gammopathy-Related Kidney Diseases. Clin J Am Soc Nephrol 2012;7(12):1964-8.
  16. Eirin A, Li Z, Zhang X, Krier JD, Woollard JR, Zhu XY, Tang H, Herrmann SM, Lerman A, Textor SC, Lerman LO. A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis. Hypertension, 2012;60(5):1242-9.
  17. Eirin A, Ebrahimi B, Zhang X, Zhu XY, Tang H, Crane JA, Textor SC, Lerman A, Lerman LO. Changes in glomerular filtration rate after renal revascularization correlate with microvascular hemodynamics and inflammation in swine renal artery stenosis. Circ Cardiovasc Interv, 2012;1;5(5):720-8.
  18. Korsmo MJ, Ebrahimi B, Woollard JR, Crane JA, Eirin A, Krier JD, Ehman RL, and Lerman LO. Magnetic resonance elastography (MRE) detects medullary renal fibrosis. Invest Radiol 2013;48(2):61-8.
  19. Krier JD, Crane JA, Eirin A, Zhu XY, Lerman A, Lerman LO. Hemodynamic determinants of peri-vascular collateral development in swine renal artery stenosis. Am J Hypertens 2013;26(2):209-17.
  20. Eirin A, Zhu XY, Li Z, Ebrahimi B, Zhang X, Tang H, Korsmo MJ, Chade AR, Grande JP, Ward CJ, Simari RD, Lerman A, Textor SC, Lerman LO. Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis. Arterioscler Thromb Vasc Biol, 2013;33(5):1006-13.
  21. Zhang X, Eirin A, Li ZL, Crane JA, Krier JD, Ebrahimi B, Pawar AS, Zhu XY, Tang H, Jordan KL, Lerman A, Textor SC, Lerman LO. Angiotensin receptor blockade has protective effects on the poststenotic porcine kidney. Kidney Int. 2013,84, 767–775.
  22. Zhang X, Li Z, Woollard JR, Eirin A, Ebrahimi B, Crane JA, Zhu XY, Pawar A, Krier JD, Jordan KL, Tang H, Textor SC, Lerman A, Lerman LO. Obesity-metabolic derangement preserves hemodynamics but promotes intra-renal adiposity and macrophage infiltration in swine renovascular disease. Am J Physiol Renal Physiol. 2013,305(3).
  23. Eirin A, Lerman LO. Darkness at the End of the Tunnel: Post-Stenotic Kidney Injury. Physiology, 2013;28:(4) 245-253.
  24. Ebrahimi B, Eirin A, Li Z, Zhu XY, Zhang X, Textor SC, Lerman LO. Mesenchymal Stem Cells Improve Medullary Inflammation and Fibrosis After Revascularization of Swine Atherosclerotic Renal Artery Stenosis. PLoS One 2013,8(7): e67474.
  25. Eirin A, Zhu XY, Woollard JR, Herrmann SM, Gloviczki ML, Saad A, Juncos LA, Calhoun DA, Rule AD, Lerman A, Textor SC, Lerman LO. Increased Circulating Inflammatory Endothelial Cells in
  26. African-Americans with Essential Hypertension. Hypertension 2013;62:585-591.
  27. Saad A, Herrmann SM, Crane JA, Glockner JF, Mckusick MA, Misra S, Eirin A, Ebrahimi B, Lerman LO, Textor SC. Renal revascularization restores blood flow and reverses tissue hypoxia, but fails to reverse inflammatory pathways or GFR. Circ Cardivasc Interv 2013, 6:428-35.
  28. Eirin A, Zhang X, Zhu XY, Tang H, Jordan KL, Grande JP, Dietz AB, Lerman A, Textor SC, Lerman LO. Renal Vein Cytokine Release as an Index of Renal Parenchymal Inflammation in Chronic Experimental Renal Artery Stenosis. Nephrol Dial Transplant 2014, 29(2):274-82.
  29. Eirin A, Williams BJ, Ebrahimi B, Zhang X, Crane JA, Herrmann SM, Lerman A, Textor SC, Lerman LO. Mitochondrial Targeted Peptides Attenuate Residual Myocardial Damage after Reversal of Experimental Renovascular Hypertension. J Hypertens 2014, 32:154-65.
  30. Khangura KK, Eirin A, Kane GC, Misra S, Textor SC, Lerman A, Lerman LO. Cardiac Function In Renovascular Hypertensive Patients With And Without Renal Dysfunction. Am J Hypertens 2014, 27(3):445-53.
  31. Li Z, Ebrahimi B, Zhang X, Eirin A, Woollard JR, Tang H, Lerman A, Wang SM, Lerman LO. Obesity-metabolic derangement exacerbates cardiomyocyte loss distal to moderate coronary artery stenosis in pigs without affecting global cardiac function. Am J Physiol Heart Circ Physiol 2014;306(7):H1087-101.
  32. Khangura KK, Eirin A, Kane GC, Misra S, Textor SC, Lerman A and Lerman LO. Extrarenal atherosclerotic disease blunts renal recovery in patients with renovascular hypertension. J of Hypertension, 2014;32(6):1300-6.
  33. Ebrahimi B, Rihal N, Wollard JR, Krier JD, Eirin A, Lerman LO. Assessment of Renal Artery Stenosis Using Intravoxel Incoherent Motion Diffusion-weighted MRI Analysis. Invest Radiol, 2014;49(10):640-6.
  34. Eirin A and Lerman LO. Mesenchymal stem cell treatment for chronic renal failure. Stem Cell Research & Therapy, 2014;(5):83.
  35. Eirin A, Ebrahimi B, Zhang X, Zhu XY, Woollard JR, He Q, Textor SC, Lerman A, Lerman LO. Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease. Cardiovasc Res, 2014;103 (4): 461-472.
  36. Zhu XY, Ebrahimi B, Eirin A, Woollard JR, Jordan KL, Ofori M, Dietz AB, Saad A, Herrmann SM, Dietz AB, Textor SC, Lerman A, Lerman LO. Renal vein levels of miRNA-26a are decreased in the post-stenotic human and swine kidney. J Am Soc Nephrol, 2014; 26:1378-88.
  37. Eirin A, Lerman A, Lerman LO. Mitochondrial injury and dysfunction in hypertension-induced cardiac damage. Eur Heart J, 2014; 7;35(46):3258-3266.
  38. Sun D, Eirin A, Zhu XY, Zhang X, Crane JA, Woollard JR, Lerman A, Lerman LO. Experimental Coronary Artery Stenosis Accelerates Kidney Damage in Renovascular Hypertensive Swine. Kidney Int, 2014;87:719-27.
  39. Eirin A, Riester SM, Zhu XY, Tang H, Evans JM, O’Brien DR, van Wijnen AJ, Lerman LO. MicroRNA and mRNA Cargo of Extracellular Vesicles from Swine Adipose Tissue-Derived Mesenchymal Stem Cells. Gene, 2014; 551(1):55-64.
  40. Pawar AS, Zhu XY, Eirin A, Tang H, Jordan KL, Woollard JR, Lerman A, Lerman LO. Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity. Obesity, 2015, 23:399-407.
  41. Eirin A, Lerman A, Lerman LO. Mitochondria: a pathogenic paradigm in hypertensive renal disease. Hypertension, 2015, 65(2):264-270.
  42. Eirin A, Zhu XY, Ebrahimi B, Krier JD, Riester SM, van Wijnen AJ, Lerman A, Lerman LO. Intra-renal delivery of mesenchymal stem cells and endothelial progenitor cells attenuates hypertensive cardiomyopathy in experimental renovascular hypertension. Cell Transplant. 2015, 19;6:7.
  43. Park MY, Herrmann S, Saad A, Eirin A, Tang H, Lerman A, Textor SC, Lerman LO. Biomarkers of Kidney Injury and Klotho in Patients with Atherosclerotic Renovascular Disease. Clin J Am Soc Nephrol. 2015,6;10:443-51.
  44. Eirin A, Irazabal MV, Fervenza FC, Sethi S. Histiocytic Glomerulopathy associated with Macrophage Activating Syndrome. Clin Kidney J, 2015,8:157-60.
  45. Eirin A, Zhu XY, Ferguson CM, Riester SM, van Wijnen AJ, Lerman A, Lerman LO. Intra-renal delivery of mesenchymal stem cells attenuates myocardial injury after reversal of hypertension in swine renovascular disease. Stem Cell Research & Therapy, 2015, 19;6:7.
  46. Fervenza FC, Gipson D Appel J, Barbour S, Rovin B, Aslam N, Lafayette R, Irazabal MV, Sethi S, Hladunewich MA, Brenchley P, Kretzler M, Canetta P, Radhakrishnan J, Hebert L, Gipson P, Thomas L, McCarthy E, Jefferson JA, Eirin A, Leung N, Cattran DC. A Multi-Center Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR). Nephron, 2015;130:159-68.
  47. Zhang X, Li Z, Eirin A, Ebrahimi B, Pawar A, Zhu YX, Lerman A, Lerman LO. Cardiac metabolic alterations in hypertensive obese pigs. Hypertension, 2015;66:430-6.
  48. Ma S, Zhu XY, Eirin A, Woollard JR, Jordan KL, Tang H, Lerman A, Lerman LO. Perirenal fat promotes renal arterial endothelial dysfunction in obese swine through tumor necrosis factor-α). Journal of Urology. In Press.

Forthcoming:

  1. Eirin A, Ferguson CM, Jordan KL, Tang H, Woollard JR, Textor SC, Lerman A, Lerman LO. Loss of mitochondrial cardiolipin contributes to renal hyperfiltration and tubular injury in early metabolic syndrome in swine. (Submitted to Kidney Int.).
  2. Eirin A, Ebrahimi B, Fiala JA, Williams BJ, Woollard JR, He Q, Gupta RC, Sabbah HN, Lerman A, Textor SC, Lerman LO. Restoration of Mitochondrial Cardiolipin Improves Left Ventricular Relaxation in Swine Renovascular Hypertension. (Submitted to Am Heart J.).
  3. Eirin A, Zhu XY, Tang H, McGurren KA, Riester SM, van Wijnen AJ, Textor SC, Lerman A, Lerman LO. Interleukin-10 mediates the renoprotective properties of mesenchymal stem cells-derived extracellular vesicles in porcine metabolic syndrome and renal artery stenosis. (Submitted to J Am Soc Nephrol).
  4. Eirin A, Saad A, Herrmann SM, Tang H, Lerman A, Textor SC, Lerman LO. Urine Mitochondrial-DNA Copy Number Identifies Renal Injury in Severe Renovascular Disease. (In Progress).
  5. Sun D, Ebrahimi B, Eirin A, Textor SC, Lerman A, Lerman LO. Atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis. (In Progress).
  6. Herrmann SM, Saad A, Eirin A, Woollard JR, Tang H, McKusick MA, Misra S, Glockner JF, Lerman LO, Textor SC. Crosstalk between Stenotic and Contralateral Kidneys:Oxygenation, Inflammatory Biomarkers and Blood Flow in Unilateral Human Atherosclerotic Renovascular Disease. (Submitted to Clin J Am Soc Nephrol).
  7. Hickson LJ, Eirin A, Lerman LO. Stem cell functionality in patients with chronic kidney disease: A barrier to delivery? (Submitted to Kidney Int.).
  8. Wang W, Saad A, Herrmann SM, Eirin A, McKusick MA, Misra S, Lerman LO, Textor SC. Pre-treatment inflammatory biomarkers and transient changes after renal revascularization in atherosclerotic renal artery stenosis (Submitted to J Am Soc Nephrol.).
  9. Zhu XY, Ma S, Eirin A, Woollard JR, Hickson LT, Sun D, Lerman A, Lerman LO. Functional plasticity of adipose tissue-derived mesenchymal stem cells during development of obesity. (Submitted to Stem Cells Trans. Med.).

Book Chapters

  1. Eirin A, Irazabal MV, Fervenza FC. Membranous Nephropathy. In: Chapter 31: Nephrology Secrets 3rd edition. Elsevier; 2011.
  2. Eirin A, Ebrahimi B, Lerman LO. Improved Revascularization Restoring Renal Function in Pigs Using Adipose-Derived Mesenchymal Stem Cells. In: Section IV: Regenerative Medicine: STEM CELLS AND CANCER STEM CELLS: Therapeutic Applications in Disease and Injury 12th volume. Springer Company, 2014.
  3. Zhang X, Eirin A. Models of Renovascular Disease. In: Chapter 7: Renal Vascular Disease. Springer Company, 2014.
  4. Eirin A, Lerman A, Lerman LO. The emerging role of mitochondrial targeting in kidney disease. Handbook of Experimental Pharmacology. Springer Company, 2015. (Submitted)

Editorials

  1. Eirin A, Ebrahimi B, Lerman LO. Cell-based Therapies as an Adjunct to Revascularization in Experimental Atherosclerotic Renovascular Disease. J Clin Exp Cardiolog 2012, 3:8. doi:10.4172/2155-9880.1000e108. PMID: 24319626.
  2. Eirin A, Lerman LO. Revascularization in Experimental Atherosclerotic Renal Artery Stenosis: Role of Mitochondrial Targeted Peptides (Bendavia). Cardiol Pharmacol, 2012, 1:3. doi: 10.4172/cpo.1000e108.
  3. Zhang X, Eirin A, Lerman A, Lerman LO. Osteopontin: An emerging therapeutic target in uremic vascular disease – Cardiovasc Res. 2013,1;98(3):332-3. PMID: 23612585.

Abstracts

  1. Relapse of Nephrotic Syndrome after Rituximab Therapy in a Patient with Idiopathic Membranous Nephropathy - Eirin A, Irazabal MV, Erickson SB, Keryakos H, Fervenza FC. J Am Soc Nephrol Abstracts Issue 20: 2009(963).
  2. Quantification of B Cell and T Cell Subsets Do Not Predict Response to Rituximab Therapy in Patients with Idiopathic Membranous Nephropathy: A Prospective Study - Eirin A, Irazabal MV, Abraham RS, Erickson SB, Nachman PH, Lieske JC, Leung N, Dillon JJ, Cattran DC, Fervenza FC. J Am Soc Nephrol Abstracts Issue 20: 2009(635).
  3. In Idiopathic Membranous Nephropathy (MN) Resistance to Rituximab Treatment Does Not Preclude Response to Cyclosporine or Cyclophosphamide - Irazabal MV, Keryakos H, Eirin A, Dillon JJ, Cattran DC, Fervenza FC. J Am Soc Nephrol Abstracts Issue 20: 2009(632-633).
  4. Fractional Excretion of High and Low Molecular Weight Proteins Correlates with Response to Rituximab (RTX) Therapy in Patients with Idiopathic Membranous Nephropathy (MN): A Prospective Study - Irazabal MV, Eirin A, Lieske JC, Borland TM, Erickson SB, Dillon JJ, Nachman PH, Cattran DC, Fervenza FC. J Am Soc Nephrol Abstracts Issue 20: 2009(632).
  5. Long-Term Outcome of Patients with Membranous Nephropathy after Rituximab Therapy - Irazabal MV, Eirin A, Erickson SB, Leung N, Dillon JJ, Keryakos H, Cattran DC, Fervenza FC. J Am Soc Nephrol Abstracts Issue 20: 2009(745).
  6. Rituximab (RTX) in the Treatment of Idiopathic Membranous Nephropathy (IMN) - Fervenza FC, Erickson SB, Nachman PH, Dillon JJ, Leung N, Hogan MC, Hickson LT, Qazi Q, Bergstralh EJ, Irazabal MV, Erin A, Cattran DC. J Am Soc Nephrol Abstracts Issue 20: 2009(745).
  7. Pharmacokinetics (PK) of Rituximab in Idiopathic Membranous Nephropathy (IMN) - Fervenza FC, Erickson SB, Nachman PH, Dillon JJ, Leung N, Hogan MC, Hickson LT, Anand B, Visich J, Irazabal MV, Eirin A, Cattran DC. J Am Soc Nephrol Abstracts Issue 20: 2009(155).
  8. Efficacy of Rasburicase in the Prevention of Acute Kidney Injury of Tumor Lysis Syndrome – Leung N, Irazabal MV, Eirin A, Gunderson HD, Fervenza FC. J Am Soc Nephrol Abstracts Issue 20: 2009(328).
  9. Differences in clinical presentation and outcomes of patients with vascular limited light chain amyloidosis (AL) versus diffuse - Leung N, Irazabal MV, Eirin A, Lacy MQ, Dispenzieri A, Buadi FK, Zeldenrust SR, Hayman SR, Kumar S, Russell SJ, Kyle RA, Ramirez-Alvarado M, Sethi S, Erickson SB, Fervenza FC, & Gertz MA. Amyloid, April 2010; 17(Suppl 1): 91–207.
  10. Engraftment syndrome presenting as acute renal failure in light chain amyloidosis patients after autologous stem cell transplantation - Leung N, Gertz MA, Dispenzieri A, Lacy MQ, Buadi F, Hayman SR, Dingli D, Hogan WJ, Irazabal MV, Eirin A, & Kumar S. Amyloid, April 2010; 17(Suppl 1): 91–207.
  11. Rituximab (RTX) therapy in idiopathic membranous nephropathy (IMN): results at 2 years - Fervenza FC, Abraham RS, Erickson SB, Irazabal MV, Eirin A, Specks U, Nachman PH, Bergstralh EJ, Leung N, Cosio FG, Hogan MC, Dillon JJ, Hickson LT, and Cattran DC. Nephrol Dial Transplant Plus 2010 3(Supplement 3): iii275–iii547.
  12. Ethnic differences in the number of endothelial progenitor cells and inflammatory biomarkers in patients with essential hypertension - Eirin A, Gloviczki ML, Gossl M, Tang H, Jordan KL, Lerman A, Textor SC, and Lerman LO. J Am Soc Nephrol Abstracts Issue 21: 2010(515).
  13. Continued renal dysfunction after percutaneous transluminal renal angioplasty (PTRA) is associated with microvascular remodeling in swine atherosclerotic renal artery stenosis (ARAS) – Eirin A, Zhu XY, Urbieta-Caceres VH, Krier J, Crane JA, Textor SC, Lerman A, and Lerman LO. J Am Soc Nephrol Abstracts Issue 21: 2010(109).
  14. Efficacy, Durability, and Immunological Analyses Following Rituximab Therapy in Idiopathic Membranous Nephropathy: A 2-year study – Fervenza FC, Abraham RS, Erickson SB, Irazabal MV, Eirin A, Specks U, Nachman PH, Bergstralh EJ, Leung N, Cosio FG, Hogan MC, Dillon JJ, Hickson LT, and Cattran DC. J Am Soc Nephrol Abstracts Issue 21: 2010(638).
  15. A multicenter experience of kidney transplantation in ANCA-associated vasculitis (AAV) in the era of modern immunosuppression – Geetha D, Eirin A, True K, Irazabal MV, Specks U, Seo P, Nachman PH, and Fervenza FC. J Am Soc Nephrol Abstracts Issue 21: 2010(804).
  16. Evaluation of Low Dose Rasburicase In the Prevention of Renal Insufficiency and Dialysis After Chemotherapy – Eirin A, Irazabal MV, Gunderson HD and Leung N. Blood 116(21), 2010: 2574.
  17. Acute Renal Failure Is a Common Presentation of Engraftment Syndrome In Light Chain Amyloidosis (AL) Patients After Autologous Stem Cell transplantation – Irazabal MV, Eirin A, Gertz MA, Dispenzieri A, Kumar S, Buadi F, Lacy MQ, Hayman SR, Dingli D, Hogan WJ, and Leung N. Blood 116(21), 2010: 3468.
  18. Renal Vein Levels of Endothelial Progenitor Cells (EPC) and Inflammatory Biomarkers in Renovascular (RVH) and Essential Hypertensive Patients (EH) – Eirin A, Gloviczki ML, Gossl M, Tang H, Jordan KL, Lerman A, Textor SC, Lerman LO. FASEB J 2011; 25:1030.2.
  19. Mesenchymal Stem Cells (MSC) Decrease Tubulointerstitial Injury and Improve Renal Function After Revascularization in Swine Atherosclerotic Renal Artery Stenosis (RAS) – Eirin A, Zhu XY,
  20. Urbieta-Caceres VH, Krier JD, Textor SC, Lerman A, Lerman LO. FASEB J 2011; 25:636.7.
  21. Renal Transplantation in ANCA associated vasculitis: Allograft Outcome and Vasculitis Relapse Rate - Geetha D, Eirin A, True K, Irazabal MV, Specks U, Seo P, Nachman PH, and Fervenza FC. Clin Exp Immunol abstract supplement. 2011; (Suppl. 1), 50–67.
  22. Treatment of Idiopathic Membranous Nephropathy with ACTH Gel (Acthar) - Bomback A, Fervenza FC, Cattran DC, Irazabal MV, Eirin A, Radhakrishnan J, Appel G. ISN Annual Meeting 2011 (OR-40).
  23. MTP-131 reduces renal injury after percutaneous transluminal renal angioplasty (PTRA) in swine atherosclerotic renal artery stenosis (ARAS) – Eirin A, Woollard JR, Zhu XY, Krier JD, Zhang X, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 22: 2011 (282A).
  24. Renal inflammation and injury signals in patients with atherosclerotic renal artery stenosis (ARAS) - Eirin A, Gloviczki ML, Gossl M, Tang H, Jordan KL, Woollard JR, Lerman A, Grande JP, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 22: 2011 (29A).
  25. Basal stenotic-kidney hemodynamics and function correlate with response to revascularization in swine renal artery stenosis (RAS) - Eirin A, Zhu XY, Krier JD, Crane JA, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue Abstracts Issue 22: 2011 (352A).
  26. Intra-renal delivery of autologous endothelial progenitor cells (EPC) improves renal function after revascularization in swine renal artery stenosis (RAS) - Zhu XY, Eirin A, Krier JD, Ebrahimi B, Zilun L, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 22: 2011 (27A).
  27. Mesenchymal Stem Cells Infusion after Revascularization of Atherosclerotic Renal Artery Stenosis Improves Renal Tubular Transport Function - Ebrahimi B, Woollard JR, Eirin A, Zhu XY, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 22: 2011 (97A).
  28. Meenchymal stem cells and endothelial progenitor cells improve renal function in experimental swine renal artery stenosis through different mechanisms - Zhu XY, Eirin A, Krier JD, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 22: 2011 (614A).
  29. Urinary biomarkers as predictors of response to rituximab in patients with membranous nephropathy - Irazabal MV, Eirin A, Lieske J, Borland TM, Sethi S, Erickson SB, Dillon JJ, Nachman PH, Cattran DC, and Fervenza FC. J Am Soc Nephrol Abstracts Issue 22: 2011 (774A).
  30. Response of Anti-PLA2R to Adrenocorticotropic hormone (ACTH) Gel in Primary Membranous Nephropathy – Beck LH, Fervenza FC, Bomback AS, Ayalon R, Irazabal MV, Eirin A, Cattran DC, Appel GB, Salant DJ. J Am Soc Nephrol Abstracts Issue 22: 2011 (33A).
  31. Chronic renovascular hypertension (RVH) is associated with elevated plasma levels of neutrophil gelatinase-associated lipocalin (NGAL) – Eirin A, Gloviczki ML, Tang H, Woollard JR, Lerman A, Textor SC, Lerman LO. Hypertension 2011;58:e142-e143.
  32. Magnetic resonance elastography (MRE) detects medullary renal fibrosis – Korsmo MJ, Ebrahimi B, Woollard JR, Crane JA, Eirin A, Krier JD, Ehman RL, and Lerman LO. FASEB J 2012;26:523.3.
  33. Dissociation between renal blood flow and oxygenation in regulating renin activity in renovascular hypertension – Herrmann S, Gloviczki ML, Eirin A, McKusick M, Glockner J, Lerman LO, and Textor SC. J Clin Hypertens 2012;14 Suppl 1 :4.
  34. Low and high molecular weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: a prospective study - Irazabal MV, Eirin A, Lieske J, Beck LH, Dillon JJ, Nachman PH, Sethi S, Erickson SB, Cattran DC, and Fervenza FC. Nephrol Dial Transplant 2012 27(Supplement 2): iii186–iii187.
  35. Treatment of membranous nephropathy with adrenocorticotropic hormone (ACTH) Gel: correlation of anti-PLA2R and disease activity – Beck LH, Fervenza FC, Bomback AS, Ayalon R, Irazabal MV, Eirin A, Cattran DC, Appel GB, and Salant DJ. Nephrol Dial Transplant 2012 27(Supplement 2): iii416–iii417.
  36. Increased Circulating Inflammatory Endothelial Cells (IEC) in African-American vs. Caucasians with Essential Hypertension – Eirin A, Herrmann SM, Gloviczki ML, Zhu XY, Tang H, Jordan KL, Juncos LA, Calhoun DA, Lerman A, Textor SC, and Lerman LO. Hypertension 2012;60:a66-a66.
  37. Valsartan at a sub-therapeutic dose ameliorates myocardial autophagy overactivated in renovascular hypertension (RVH) – Zhang X, Li Z, Pawar AS, Crane JA, Eirin A, Lerman A, Lerman LO. Hypertension Hypertension 2012;60:a222-a222.
  38. Adipose-Derived Mesenchymal Stem Cells Regulate miRNA Expression in Renovascular Disease and Decrease Apoptosis and Renal Injury – Zhu XY, Ebrahimi B, Eirin A, Jordan KL, Krier JD, Grande JP, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (417A-418A).
  39. Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes after Revascularization in Experimental Atherosclerotic Renal Artery Stenosis - Eirin A, Li Z, Zhang X, Krier JD, Woollard JR, Zhu XY, Tang H, Herrmann SM, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (80A-81A).
  40. Endothelial progenitor cells (EPC) induce macrophage phenotypic switch and improve renal recovery capacity in swine renal artery stenosis (RAS) – Eirin A, Zhu XY, Li Z, Ebrahimi B, Zhang X, Tang H, Korsmo MJ; Chade AR; Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (291A).
  41. Renal Vein Cytokine Release as an Index of Renal Parenchymal Inflammation in Chronic Experimental Renal Artery Stenosis - Eirin A, Zhang X, Tang H, Jordan KL, Zhu XY, Herrmann SM, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (292A).
  42. Mitochondrial Targeted Peptides Attenuate Myocardial Damage after Renal Revascularization in Experimental Atherosclerotic Renovascular Hypertension - Eirin A, Crane JA, Zhang X, Li Z, Zhu XY,
  43. Herrmann SM, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (291A-292A).
  44. Bendavia, a mitochondrial permeability transition pore (MTP) inhibitor, preserves oxygenation and renal blood flow in Swine Atherosclerotic Renovascular Disease – Eirin A, Ebrahimi B, Zhang X, Krier JD, Korsmo MJ, Crane JA, Zhu XY, Herrmann SM, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue (292A-293A).
  45. Falsely Elevated Serum Creatinine in a Patient with a Monoclonal Gammopathy – Eirin A, Lieske JC, Buadi FK, Larson TS, Hogan MC. J Am Soc Nephrol Abstracts Issue 23: 2012 (616A-617A).
  46. Metabolic syndrome exacerbates renal hyperfiltration and fat deposition in renovascular hypertension – Zhang X, Li Z, Eirin A, Tang H, Jordan KL, Woollard JR, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (479A).
  47. Obesity Magnifies Kidney and Peri-Renal Fat Inflammation and Fibrosis in Experimental Renal Artery Stenosis – Zhang X, Li Z, Eirin A, Jordan KL, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (479A).
  48. Renal TGF-beta in transjugular biopsies is associated with reduced blood flow rather than oxygenation in human atherosclerotic renal artery stenosis - Herrmann SM, Gloviczki ML, Saad A, Eirin A, McKusick M, Lerman LO, Textor SC. J Am Soc Nephrol Abstracts Issue 23: 2012 (607A).
  49. Dent’s Disease Presenting as Global Glomerulosclerosis – Eirin A, Irazabal MV, Lieske J, Nasr S, Sethi S, Fervenza FC. J Am Soc Nephrol Abstracts Issue 23: 2012 (366A).
  50. Histiocytic Glomerulopathy associated with Macrophage Activating Syndrome – Eirin A, Irazabal MV, Fervenza FC, Sethi S. J Am Soc Nephrol Abstracts Issue 23: 2012 (537A-538A).
  51. Angiotensin II Receptor Blocker Improves the Stenotic Kidney Microvasculature in Swine Unilateral Renal Artery Stenosis – Zhang X, Li Z, Eirin A, Crane JA, Pawar A, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 23: 2012 (29A).
  52. A Pilot Study to Determine Dose, Effectiveness and Depletion of Anti-PLA2R Antibodies of Adrenocorticotrophic Hormone (ACTH Acthar® Gel) in Subjects with Nephrotic Syndrome and Idiopathic Membranous Nephropathy (iMN) – Hladunewich MA, Fervenza FC, Beck LH, Reich HN, Sethi S, Irazabal MV, Eirin A, Ayalon R, Cattran DC. J Am Soc Nephrol Abstracts Issue 23: 2012 (58A).
  53. Intravenous infusion of Bendavia during renal revascularization attenuates cardiac injury and dysfunction in swine renovascular hypertension (RVH)- Williams BJ, Eirin A, Ebrahimi B, Zhang X, Woollard JR, Tang H, Jordan KL, Crane JA, Lerman A and Lerman LO. FASEB J 2013;27:1131.14.
  54. Renal inflammation and injury markers correlate directly with cortical and fractional hypoxia measured with Blood Oxygen Level Dependent (BOLD) MR in human atherosclerotic renal artery stenosis. Saad A, Herrmann SM, Crane JA, Eirin A, Tang H, Glockner J, McKusick M, Lerman LO, Textor SC. Hypertension 2013;62: A285.
  55. Chronic treatment with Bendavia Restores Renal Function in Swine Atherosclerotic Renal Artery Stenosis Eirin A, Zhang X, Krier JD, Crane JA, Woollard JR, Zhu XY, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 24: 2013 (866A).
  56. Mitochondrial Targeted Peptide Attenuate Myocardial Damage in Experimental Atherosclerotic Renovascular Disease. Eirin A, Zhang X, Krier JD, Zhu XY, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 24: 2013 (866A-867A).
  57. Experimental Coronary Artery Disease Accelerates Kidney Fibrosis in Hypertensive Swine. Sun D, Eirin A, Zhu XY, Zhang X, Crane JA, Woollard JR, Lerman A and Lerman LO. J Am Soc Nephrol Abstracts Issue 24: 2013 (869A).
  58. Renal vein inflammatory and injury biomarkers are associated with net renin release and persist despite ACE/ARB RX in human atherosclerotic renal artery stenosis. Herrmann SM, Saad A, Eirin A, Lerman LO, Textor SC. J Am Soc Nephrol Abstracts Issue 24: 2013 (868A).
  59. Quantitative Measurement of vascular Occlusion Is Associated with tissue Hypoxia and Inflammatory Cytokines in Human Atherosclerotic Renal Artery Stenosis. Saad A, Herrmann SM, Eirin A, Lerman LO, Textor SC. J Am Soc Nephrol Abstracts Issue 24: 2013 (871A).
  60. Long-term therapy with Bendavia (MTP-131) reverses myocardial structural and molecular abnormalities in a pig model of hypertension with isolated left ventricular diastolic dysfunction. Sabbah HN, Eirin A, Gupta RC, Lerman A, Lerman LO. Eur Heart J (2014) 35 (suppl 1): 851-1187.
  61. Mesenchymal stem cells-derived micro-particles attenuate kidney injury in swine metabolic syndrome and renal artery stenosis. Eirin A, Zhu XY, McGurren KA, Tang H, van Wijnen AJ, Grande JP, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 25: 2014 (224A-225A).
  62. Mitochondrial protection preserves kidney function in swine metabolic syndrome. Eirin A, Ferguson CM, Krier JD, Jordan KL, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 25: 2014 (213A-214A).
  63. Atherosclerosis aggravates renal microvascular loss and hypoxia in swine renal artery stenosis (RAS). Sun D, Ebrahimi B, Eirin A, Textor SC, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 25: 2014 (711A-711B).
  64. Tumor necrosis factor-alpha enhances adipogenesis of adipose tissue-derived mesenchymal stem cells during evolution of obesity. Zhu XY, Ma S, Eirin A, Wollard JR, Jordan KL, Tang H, Lerman A, Lerman LO. (ATVB/PVD 2015, Accepted).
  65. Functional Alterations of Adipose-Derived Mesenchymal Stem Cells from Human with Atherosclerotic Renovascular Disease Under Hypoxic Conditions. Saad A, Dietz A, Herrmann SM, Eirin A, Abohashem Aly AA, Tang H, Kwon SH, Jordan KL, Woollard JR, Grande JP, Lerman LO, Textor SC. J Am Soc Nephrol Abstracts Issue 26: 2015 (404A)
  66. Safety of Intra-Arterial Autologous Adipose-Derived Mesenchymal Stem Cells in Human Atherosclerotic Renovascular Disease. Saad A, Herrmann SM, Mckusick MA, Misra S, Glockner J, Eirin A, Grande JP, Dietz AB, Wang W, Lerman LO, Textor SC. J Am Soc Nephrol Abstracts Issue XX: 2015 (404A-404B).
  67. Urine Mitochondrial-DNA Copy Number Identifies Renal Injury in Severe Renovascular Disease. Eirin A, Saad A, Herrmann SM, Tang H, Lerman A, Textor SC, Lerman LO. J Am Soc Nephrol Abstracts Issue 26: 2015 (777A).
  68. Interleukin-10 mediates the renoprotective properties of mesenchymal stem cells-derived extracellular vesicles in porcine metabolic syndrome and renal artery stenosis. Eirin A, Zhu XY, Ferguson CM, Riester SM, van Wijnen AJ, Lerman A, Lerman LO. J Am Soc Nephrol Abstracts Issue 26: 2015 (388A-388B).
  69. Elevated Renal Injury Biomarkers Fall Transiently After Stenting in Human Atherosclerotic Renal Artery Stenosis (ARAS). Wang W, Saad A, Herrmann S, Eirin A, Tang H, Lerman LO, Textor SC. J Am Soc Nephrol Abstracts Issue 26: 2015 (677A-677B).

 

 

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