Chung-Hsi Hsing
Chung Hsi Hsing, MD,PhD
Associate Professor of Anesthesiology

Chi-Mei Medical Center


  1982-1989 Bachelor, Medicine, National Defense Medical Center 
  1989-1991 M.S., Institute of Pathology, National Defense Medical Center
  2004-2008 Ph.D., Institute of Biopharmaceutical Sciences, National Cheng Kung University



Chung-Hsi Hsing, anesthesiologist. Grantee Medical Research, Chi Mei Medical Center, 2005. Member of Taiwan Society Anesthesiologists (secretary 2002-2004), Chinese Association Study of Pain (associate), Taiwan Society Critical Care Medicine (associate), Taiwan Society Anesthesiologists (associate).


Research Interest

  1. Molecular Biology
  2. Immunology
  3. Critical Care Medicine and Pharmacology
  4. Cardiovascular Anesthesiology


Professional Activities:



  1. Chu CC, Shieh JP, Shui HA, Chen JY, Hsing CH, Tzeng JI, Wang JJ, Ho ST. Tianeptine reduces morphine antinociceptive tolerance and physical dependence. Behav Pharmacol. 2010 Sep;21(5-6):523-9 (SCI IF: 2.194, Ranking 51.6%).
  2. Edmund Cheung So, Ya-Ting Chang, Chung-Hsi Hsing, Paul Wai-Fung Poon, Sew-Fen Leu, Bu-Miin Huang. The effect of midazolam on mouse Leydig cell steroidogenesis and apoptosis. Toxicology Letters 2010; 192: 169-178 (SCI IF: 3.355, Ranking 23.0%).
  3. Hsing CH, Chou W, Wang JJ, Chen HW, Yeh CH. Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury. Nephrol Dial Transplant 2011; 26: 1162-1172 (SCI IF: 3.488, Ranking 14.3%).
  4. Ching-Hua Yeh, Willy Chou, Edmund Cheung So, Chin-Chen Chu, Ming-Chung Lin, Jhi-Joung Wang, and Chung-Hsi Hsing* (corresponding author). Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia inducible factor-1a expression. British Journal of Anaesthesia 2011; 106(4): 590-599 (SCI IF: 4.354, Ranking 10.3%).
  5. Chung-Hsi Hsing*, Ming-Chung Lin, Pui-Ching Choi, Wei-Ching Huang, Jui-In Kai, Cheng-Chieh Tsai, Yi-Lin Cheng, Chia-Yuan Hsieh, Chi-Yun Wang, Yu-Ping Chang, Yu-Hong Chen, Chia-Ling Chen, Chiou-Feng Lin* (*corresponding author). Anesthetic Propofol Reduces Endotoxic Inflammation by Inhibiting Reactive Oxygen Species-regulated Akt/IKKβ/NF-κB Signaling. PLoS ONE 2011 Mar 8; 6:e17598 (SCF IF: 3.534, Ranking 14.5%).
  6. Ching-Hua Yeh, Bor-Chih Cheng, Chuan-Chih Hsu, Hung-Wei Chen, Jhi-Joung Wang, Ming-Shi Chang, Chung-Hsi Hsing* (*corresponding author). Induced interleukin-19 in patients undergoing CABG with CPB contributes to cell-mediated immunosuppression. Annals of Thoracic Surgery 2011; 92:1252-9 (SCI IF: 3.631, Ranking 7.8%). 
  7. Ching-Hua Yeh, Willy Chou, Chin-Chen Chu, Huai-Chia Chang, Edmund Cheung So, Jhi-Joung Wang, and Chung-Hsi Hsing* (*corresponding author). Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide. Shock 2011; 36 (5): 510-6 (SCI IF: 2.732, Ranking 19.1%).
  8. Chung-Hsi Hsing, Yu-Hong Chen, Chia-Ling Chen, Wei-Ching Huang, Ming-Chung Lin, Chi-Yun Wang, Cheng-Chieh Tsai, Pui-Ching Choi, Po-Chin Tseng, Chiou-Feng Lin. Anaesthetic Propofol Causes Glycogen Synthase Kinase-3-regulated Lysosomal/mitochondrial Apoptosis in Macrophages. Anesthesiology 2012; 116:868-881 (SCI IF: 6.168, Ranking 3.4%).
  9. Chung-Hsi Hsing, Hong-Chi Cheng, Chien-Hui Chan, Yu-Hsiang Hsu, Ching-Hua Yeh, Chien-Feng Li, and Ming-Shi Chang. Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome. Clinical Cancer Research 2012; 18(3): 713-725 (SCI IF: 8.193, Ranking 6.4%).
  10. Yu-Hsiang Hsu, Chung-Hsi Hsing, Chien-Feng Li, Chien-Hui Chan, Ming-Chung Chang, Jing-Jou Yan, and Ming-Shi Chang. Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models. J Immunology 2012; 188; 1981-1991 (SCI IF: 5.362, Ranking 16.7%).
  11. Chung-Ching Lin, Liang-Tzung Lin, Ming-Hong Yen, Juei-Tang Cheng, Ching-Hua Yeh* and Chung-Hsi Hsing* (*corresponding author). Renal protective effect of Xiao-Chai-Hu-Tang on diabetic nephropathy of type 1-diabetic mice. Evidence-Based Complementary and Alternative Medicine 2012; Article ID 984024, doi:10.1155/2012/984024 (SCI IF: 2.175, Ranking 27.3%).
  12. Ming-Chung Lin, Chia-Ling Chen, Tsan-Tzu Yang, Pui-Ching Choi, Chung-Hsi Hsing*, and Chiou-Feng Lin* (*corresponding author). Anesthetic propofol overdose causes endothelial cytotoxicity in vitro and endothelial barrier dysfunction in vivo. Toxicology and Applied Pharmacology 2012 (265); 253-262 (SCI IF: 3.630, Ranking 18.4%).
  13. Edmund Cheung So, Chung-Hsi Hsing, Chia-Hua Liang, Sheng-Nan Wu. The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K+ current and membrane potential in HL-1 murine atrial cardiomyocytes. European Journal of Pharmacology 2012; 683:1-9 (SCI IF: 2.684, Ranking 38.3%).
  14. Chung-Hsi Hsing, Chiou-Feng Lin, Edmund So, Ding-Ping Sun, Tai-Chi Chen, Chien-Feng Li, Ching-Hua Yeh. Alpha-2 adrenoceptor agonist-dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. American Journal of Physiology - Renal Physiology 2012; 303; F1443-F1453 (SCI IF: 3.300, Ranking 19.5%).
  15. Ching-Yih Lin, Yu-Feng Tian, Li-Ching Wu, Li-Tzong Chen, Li-Ching Lin, Chung-Hsi Hsing, Sung-Wei Lee, Ming-Jen Sheu, Hao-Hsien Lee, Yu-Hui Wang, Yow-Ling Shiue, Wen-Ren Wu, Hsuan-Ying Huang, Han-Ping Hsu, Chien-Feng Li, Shang-Hung Chen. Rsf-1 expression in rectal cancer: with special emphasis on the independent prognostic value after neoadjuvant chemoradiation. Journal of clinical pathology 2012; 65(8):687-92. (SCI IF: 2.551, Ranking 32.9%).
  16. Jen-Wei Tsai, Chien-Feng Li, Yu-Chien Kao, Jun-Wen Wang, Fu-Min Fang, Yu-Hui Wang, Wen-Ren Wu, Li-Ching Wu, Chung-Hsi Hsing, Shau-Hsuan Li, Shih-Chen Yu, Jui Lan, Hsuan-Ying Huang. Recurrent Amplification at 7q21.2 Targets CDK6 Gene in Primary Myxofibrosarcomas and Identifies CDK6 Overexpression as an Independent Adverse Prognosticator. Annals of surgical oncology 2012; 19(8):2716-25 (SCI IF 3.943, Ranking 6.4%).
  17. Chung-Ching Chio, Jia-Wei Lin, Heien-An Cheng, Yuan-Hung Wang, Jhi-Joung Wang, Chung-Hsi Hsing, Ruei-Ming Chen. MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells. Arch Toxicol 2013; 87:459–468 (SCI IF 5.078, Ranking 10.3%).
  18. Ying-Yin Chen, Chien-Feng Li, Ching-Hua Yeh, Ming-Shi Chang, and Chung-Hsi Hsing* (*corresponding author). Interleukin-19 in Breast Cancer (review article). Clinical and Developmental Immunology 2013; ID 294320: 9 pages (SCI IF 2.934, Ranking 46.5%).
  19. Ding-Ping Sun, Ching-Hua Yeh, Edmund So, Li-Yun Wang, Tsui-Shan Wei, Ming-Shi Chang, Chung-Hsi Hsing* (*corresponding author). Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression. Cytokine 2013; 62: 360-368 (SCI IF 2.874, Ranking 47.2%).
  20. Huang HY, Wu WR, Wang YH, Wang JW, Fang FM, Tsai JW, Li SH, Hung HC, Yu SC, Lan J, Shiue YL, Hsing CH, Chen LT, Li CF. ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance. Clin Cancer Res 2013; 19(11):2861-2872(SCI IF: 8.193, Ranking 6.4%).
  21. Lee SW, Chen TJ, Lin LC, Li CF, Chen LT, Hsing CH, Hsu HP, Tsai CJ, Huang HY, Shiue YL.Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma. Exp Mol Pathol. 2013; 5(1):83-90 (SCI IF 2.881, Ranking 26.3%).
  22. Sun DP, Lin CY, Tian YF, Chen LT, Lin LC, Lee SW, Hsing CH, Lee HH, Shiue YL, Huang HY, Li CF, Liang PI. Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression. Tumour Biol. 2013; 34(5):3059-69. doi: 10.1007/s13277-013-0872-2 (SCI IF 2.840, Ranking 45.8%). 
  23. Liang PI, Wang YH, Wu TF, Wu WR, Liao AC, Shen KH, Hsing CH, Shiue YL, Huang HY, Hsu HP, Chen LT, Lin CY, Tai C, Wu JY, Li CF. IGFBP-5 overexpression as a poor prognostic factor in patients with urothelial carcinomas of upper urinary tracts and urinary bladder. J Clin Pathol. 2013; 66(7):573-82 (SCI IF 2.551, Ranking 32.9%).
  24. Hong MY, Tseng CC, Chuang CC, Chen CL, Lin YH, Hsieh CY, Chang YT, Hsing CH, Chang KY, Lin CF. Uropathogenic Escherichia coli causes cortical tubular necrotic cell death and the release of macrophage migration inhibitory factor. Cytokine. 2013; 61(3):945-52 (SCI IF 2.874, Ranking 47.2%).
  25. Tian YF, Chen TJ, Lin CY, Chen LT, Lin LC, Hsing CH, Lee SW, Sheu MJ, Lee HH, Shiue YL, Huang HY, Pan HY, Li CF, Chen SH. SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential. Tumour Biol. 2013; 34(2):1107-17 (SCI IF 2.840, Ranking 45.8%).
  26. Kao YC, Lee SW, Lin LC, Chen LT, Hsing CH, Hsu HP, Huang HY, Shiue YL, Chen TJ, Li CF. Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma. Tumour Biol. 2013; 34(2):759-68 (SCI IF 2.840, Ranking 45.8%).
  27. Chung-Hsi Hsing, Franky Antonius Kwok, Hung-Chi Cheng, Chien-Feng Li, Ming-Shi Chang. Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression. PLoS ONE 2013: 8(10): e75254. doi:10.1371/journal.pone.0075254 (SCI IF 3.534, Ranking 14.5%).
  28. Ying-Yin Chen, Ching-Hua Yeh, Edmund Cheung So, Ding-Ping Sun, Li-Yun Wang, Chung-Hsi Hsing* (*corresponding author). Anticancer drug 2-methoxyestradiol protects against renal ischemia-reperfusion injury by reducing inflammatory cytokines expression. BioMed Research International (J Biomed Biotechnol) 2014; 2014:431524. doi: 10.1155/2014/431524 (SCI IF 2.706, Ranking 32.1%).
  29. Li CF, He HL, Wang JY, Huang HY, Wu TF, Hsing CH, Lee SW, Lee HH, Fang JL, Huang WT, Chen SH. Fibroblast growth factor receptor 2 overexpression is predictive of poor prognosis in rectal cancer patients receiving neoadjuvant chemoradiotherapy. J Clin Pathol. 2014 Sep 30. pii: jclinpath-2014-202551. doi: 10.1136/jclinpath-2014-202551 (SCI IF 2.551, Ranking 32.9%).
  30. Chang CY, Lui TN, Lin JW, Lin YL, Hsing CH, Wang JJ, Chen RM. Roles of microRNA-1 in hypoxia-induced apoptotic insults to neuronal cells. Arch Toxicol. 2014 Sep 20. [Epub ahead of print] PubMed PMID: 25238743 (SCI IF 5.078, Ranking 10.3%).
  31. He HL, Lee YE, Shiue YL, Lee SW, Lin LC, Chen TJ, Wu TF, Hsing CH, Huang HY, Wang JY, Li CF. Overexpression of REG4 confers an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy. J Surg Oncol. 2014 Aug 22. doi: 10.1002/jso.23764. [Epub ahead of print] PubMed PMID: 25155043 (SCI IF 2.843, Ranking 16.7%).
  32. Lee YY, Li CF, Lin CY, Lee SW, Sheu MJ, Lin LC, Chen TJ, Wu TF, Hsing CH. Overexpression of CPS1 is an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy. Tumour Biol. 2014 Nov; 35(11):11097-105. PubMed PMID: 25099619 (SCI IF 2.840, Ranking 45.8%).
  33. Leong SL, Lin YT, Hsing CH, Lan KM, Lin MC. Unanticipated difficult nasotracheal extubation following oral surgery. Acta Anaesthesiol Taiwan. 2014 Dec;52(4):197-200. doi: 10.1016/j.aat. 2014.03.004. PubMed PMID: 25073753.
  34. Lee YE, He HL, Lee SW, Chen TJ, Chang KY, Hsing CH, Li CF. AMACR overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma. Tumour Biol. 2014 Aug;35(8):7983-91. doi: 10.1007/s13277-014-2065-z. PubMed PMID: 24833092 (SCI IF 2.840, Ranking 45.8%).
  35. Chu CC, Hsing CH, Shieh JP, Chien CC, Ho CM, Wang JJ. The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting. Eur J Pharmacol. 2014 Jan 5;722:48-54. doi: 10.1016/j.ejphar.2013.10.008. Epub 2013 Nov 1. Review. PubMed PMID: 24184695 (SCI IF 2.684, Ranking 38.3%).
  36. Liang PI, Li CF, Chen LT, Sun DP, Chen TJ, Hsing CH, Hsu HP, Lin CY. BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma. Tumour Biol. 2014 Feb;35(2):1417-26. doi: 10.1007/s13277-013-1195-z. Epub 2013 Oct 11. PubMed PMID: 24114011 (SCI IF 2.840, Ranking 45.8%).
  37. Lee SW, Lin CY, Tian YF, Sun DP, Lin LC, Chen LT, Hsing CH, Huang CT, Hsu HP, Huang HY, Wu LC, Li CF, Shiue YL. Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma. APMIS. 2014 Mar;122(3):206-14. doi: 10.1111/apm.12136. Epub 2013 Jul 24. PubMed PMID: 23879533 (SCI IF 1.922, Ranking 56.6%).
  38. Edmund Cheung So, Hui-Pin Lu, Chung-Hsi Hsing, Sheng-Nan Wu, Yu-Kai Chang, Paul WF Poon. Evaluation of Microvasculature at the Auditory Midbrain–The Benefits of Sectioning at a Tangential Angle. Microsc Res Tech. 2015: 78; 105–110.
  39. Hsu YH, Wu CY, Hsing CH, Lai WT, Wu LW, Chang MS. Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models. PLoS One. 2015 Oct 6;10(10):e0139871. doi: 10.1371/journal.pone.0139871. PMID: 26440411.
  40. I Yu HP, Chaudry IH, Choudhry MA, Hsing CH, Liu FC, Xia Z. Inflammatory Response to Traumatic Injury: Clinical and Animal Researches in Inflammation. Mediators Inflamm. 2015; 2015:729637. doi: 10.1155/2015/729637. Epub 2015 Jul 28. PMID: 26290624.
  41. Hsing CH, Hung SK, Chen YC, Wei TS, Sun DP, Wang JJ, Yeh CH. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators Inflamm. 2015;2015:163140. doi: 10.1155/2015/163140. Epub 2015 Jul 27. PMID: 26273133.
  42. Lee YE, He HL, Chen TJ, Lee SW, Chang IW, Hsing CH, Li CF. The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area. Am J Transl Res. 2015 May 15;7(5):912-21. PMID: 26175852.
  43. Hsing CH, Chen CL, Lin WC, Lin CF. Propofol Treatment Inhibits Constitutive Apoptosis in Human Primary Neutrophils and Granulocyte-Differentiated Human HL60 Cells. PLoS One. 2015 Jun 10;10(6):e0129693. doi: 10.1371/journal.pone.0129693. PMID: 26061531.
  44. Lin MC, Lin CF, Li CF, Sun DP, Wang LY, Hsing CH. Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production. Int J Mol Sci. 2015 May 27;16(6):12092-107. doi: 10.3390/ijms160612092. PMID: 26023717.
  45. So EC, Huang YM, Hsing CH, Liao YK, Wu SN. Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines. Eur J Pharmacol. 2015 Jul 5;758:177-87. doi: 10.1016/j.ejphar.2015.03.065. Epub 2015 Apr 2. PMID: 25843414.
  46. Hsing CH, Wang JJ. Clinical implication of perioperative inflammatory cytokine alteration. Acta Anaesthesiol Taiwan. 2015 Mar;53(1):23-8. doi: 10.1016/j.aat.2015.03.002. Epub 2015 Mar 30. Review. PMID: 25837846.
  47. He HL, Lee YE, Chen HP, Hsing CH, Chang IW, Shiue YL, Lee SW, Hsu CT, Lin LC, Wu TF, Li CF. Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer. Exp Mol Pathol. 2015 Jun;98(3):338-45. doi: 10.1016/j.yexmp.2015.03.029. Epub 2015 Mar 21. PMID: 25805104.


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