Clinical Anesthesia and Management-Sci Forschen

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Study the Conflict about Using Propofol Safely by Non- anesthesia Providers?

  Ali Saad*   

MBBCH, MS Anesthesia, Critical care, Mansourah University, Faculty of Medicine, Egypt

*Corresponding author: Ali Saad, MBBCH, MS Anesthesia, Critical care, Mansourah University, Faculty of Medicine, Egypt, E-mail:

Article Information

Article Type: Editorial

Citation: Ali Saad (2018) Study the Conflict about Using Propofol Safely by Non- anesthesia Providers? J Clin Anesth Manag 3(1): dx.doi. org/10.16966/2470-9956.134

Copyright: © 2018 Ali Saad. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history: 

  • Received date: 19 Feb, 2018

  • Accepted date: 07 Mar, 2018

  • Published date: 13 Mar, 2018

  • Propofol (Diprivan) was first prepared in early 1970s in the UK by Imperial Chemical Industries as ICI 35868 [1,2].

    Clinical trials followed in 1977, first by Kay and Rolly, using a form soluble in cremophor EL confirmed the fact of propofol as an anesthetic to induce anesthesia. The emulsified form was re- introduced in 1986 by ICI (now AstraZeneca); named Diprivan (abbreviated form of di-isopropyl IV anesthetic) [3]. Then used as sedative-hypnotic in U.S.A in 1989.

    Propofol is an ideal agent for relatively short outpatient procedures such as upper endoscopy and colonoscopy [3,4].

    Propofol is best agent of making patient asleep (sedation), predictable loss of memory and decreased tension; stress (anxiolysis), while providing for a rapid recovery with minimal side effects. Propofol has recently been approved by the Food and Drug Administration for use as a sedative during local and regional anesthesia. Preliminary studies [1-3] with lowdose propofol infusions suggest that it possesses many of these preferred functions. Shafer et al. [5] suggested a good correlation between the blood levels of propofol. It is Non barbiturate short acting intravenous anesthetic agent, alkyl phenol [3].

    Structure: 2,6 di-isopropylphenol, the color of solution is Milky white and is available in 1% and 2% concentration.

    The form also contains soybean oil, Egg, Lecithin & glycerol. So injection is painful. Propofol should not be assorted with other medications prior to administration. Exact mechanism of action of propofol is still not clear; it is Ultra short-acting anesthetic.

    -Research study is a prospective, randomized clinical trial** case study.

    Assessment of data on using propofol by non-anesthetists is complex due to many factors, mostly lack of strong evidenced studies that support the conclusions made. In addition, a direct comparison among the different specialties cannot be made. Procedural needs, patient clinical features, and defined endpoints are totally different for each specialty. Gastrointestinal tract endoscopy has evolved from minor procedures such as colonoscopy and diagnostic EGD that require only light sedation, to more invasive and complex ones as ERCP and EUS [6-9].

    The traditional approach was to use a benzodiazepine with or without a narcotic and these is the combination against which propofol-based sedation protocols with or without adjuvants is compared. Similarly, emergency medical service physicians always need to make patient to be asleep with no pain to perform minor, painful procedures as the reduction of a dislocated joint or closed fracture. Starting radiologic procedures for pediatrics led to the development of pediatric sedation units (PSUs). The teams concerned with sedation are sometimes supervised at a distance by pediatric intensive caregivers or emergency medical service physicians [10,11].

    As these cases sometimes take long time of sedation, propofol is one of several options used. Finally, dentists started to do painful procedures either under local infiltration or blocking peripheral nerves supplying teeth and mouth. However, patients may need sedation with the procedure, especially with blocking the nerve supply or giving local anesthetic. All new studies recommend sedation to be given during the whole procedure with maintained good response [12-14]. Using Propofol by non-anesthetists started to increase because of more demand by both patients and physicians and more procedures being done out of the operation rooms [15- 18].


    Using propofol by non-anesthetists may not stop. Generally, propofol can be used safely than other well known drugs. However, teaching non-anesthetists who are giving care for the patient is needed to manage patient without any harm. Considering complications for non-fasted patients and providing good practice to avoid and rescue from deep levels of sedation are essential. Monitoring must be standard and adequate. The medical branches that use sedation should come together on fixed definitions of level of sedation. The sedation related adverse events in patients administered propofol by non-anesthesiologists are extremely low. We cannot compare such outcomes with anesthesia providers, as similar studies are not available. Anesthetists need to be ready to clarify the use of these strong drugs by non-anesthetists in a more controlled behavior [14]. The American society of anesthesiologists (ASA) has already settled all needed documents to explain any coming events clearly.


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