Zongbing You
Zongbing You
Associate Professor

Department of Structural & Cellular Biology
Tulane University


Bachelor of Medicine 1989 West China University of Medical Sciences, China
Ph.D- Gynecology and Obstetrics 1994 West China University of Medical Sciences, China




Research Interest

  • Interleukin-17 in Prostate Cancer
  • Doublecortin in Articular Joint Development


Professional Activities:

  • American Association for Cancer Research (2002 – present, active member 84336)
  • Society for Basic Urologic Research (2008 – present, active member 124598)
  • Member of Membership Committee, 2011-present
  • International Chinese Musculoskeletal Research Society (ICMRS)
  • Orthopaedic Research Society (2009–present, active member 00216421)
  • Paul R. Lipscomb Orthopaedic Society (2003- 2008)
  • University of California Davis Cancer Center (200 –2008)
  • American Society for Cell Biology (2002–2005)
  • American Society for Biochemistry and Molecular Biology (2002– 2005)



  1. 1995  Z Cao, Z You, S Zhou, Z Peng, J Wang, P Li.  Chemotherapy against lymphatic metastases of gynecologic cancer via pelvic retroperitoneal cannulation: a preliminary report. Chinese Journal of Obstetrics and Gynecology, 30 (3): 148-152.
  2. 1996  Z Cao, Z You, S Zhou, Z Peng, J Wang,  P Li.  Chemotherapy for  lymphatic metastatic gynecologic cancer via pelvic retroperitoneal cannulation -a preliminary report. Gynecologic Oncology, 63 (3): 358-363.
  3. 1996  Z You, Y Guo, H Wen, X Fu, X Zhang, L Cao, Z Cao. Mutations of p53 gene exons 5 to 8 in human ovarian cancer and its clinical significance. Chinese Journal  of Obstetrics and Gynecology, 31 (11):660-663.
  4. 1997  Z Cao, D Zhang, Z Peng, P Li, S Zhou, Y Yang, X Yao, Z You. Chemotherapy repeated injection via pelvic retroperitoneal cannulation. Chinese Journal of Obstetrics and Gynecology, 32 (8): 471-475.
  5. 1997  Z You, Y Guo, Z Cao, F Liu, Q Zhang, S Zheng.  In vitro study of the antitumor activity of a newly synthesized organic selenium-935. Chinese Journal of Obstetrics and Gynecology, 32 (4):244-245.
  6. 1997  Z You, Y Guo, Q Dan, Z Cao. Regulation of Cathepsin D expression by Estradiol and Medroxyprogesterone in OVCAR-3 cells. Chinese Journal of Obstetrics and Gynecology, 32 (5): 313-314.
  7. 1997  J Cui, Y Guo, Z You, H Wen, Z Cao. LH-CG receptor protein expression in  epithelial ovarian cancer. Chinese Journal of Obstetrics and Gynecology, 32 (12): 742-745.
  8. 1997  Z You, Y Guo, Z Cao. Biologic effects of introduction of wild-type p53 cDNA into a human ovarian cancer cell line SKOV-3. Chinese Journal of Obstetrics and  Gynecology, 32 (12):715-717.
  9. 1998  H Shi, Z You, Y Guo. The regulation of the expression of BRCA1 protein by estrogen on ovarian cancer cell lines. Henan Journal of Oncology, 11 (4): 255-257.
  10. 1998  H Shi, Z You, Y Guo. Mutation of breast cancer susceptibility gene in ovarian cancer and its clinical significance. Chinese Journal of Obstetrics and Gynecology, 33 (11):676-678.
  11. 1998  H Shi, Z You, Y Guo, Z Cao. BRCA1 mutation and hereditary breast cancer-ovarian cancer syndrome (Review). Foreign Medical Sciences (Obstetrics and  Gynecology section), 25(4): 209-212.
  12. 1998  H Shi, Z You, Y Guo, Z Cao. BRCA1: the susceptibility gene responsible for hereditary breast cancer-ovarian cancer syndrome (Review). Chinese Journal of Medical Genetics, 5(2):115-117.
  13. 1999  Z Cao, D Zhang, Z Peng, S Zhou, P Li, Y Yang, C Zhang, Z You. The contrast   between chemotherapy via pelvic retroperitoneal cannulation and intraperitoneal  chemotherapy in gynecological malignancies cancers with lymph node metastases. Chinese Journal of Obstetrics and Gynecology, 34 (9): 540-543.
  14. 1999  J Meng, Z You, Y Guo. Effects of estradiol and medroxyprogesterone on the growth and Doxorubin-resistance of drug-resistant human epithelial ovarian cancer cell line OVCAR-3. Chinese Journal of Obstetrics and Gynecology, 34 (11): 670- 673.
  15. 2000  X Yun, Z You, Y Guo, D Haiou, Q Liao. Medroxyprogesterone on the reversal of multidrug resistance in ovarian cell line. Chinese Journal of Practical Gynecology and Obstetrics, 16 (9): 51-544.
  16. 2001  S Chen, DC Guttridge, Z You, Z Zhang, A Fribley, MW Mayo, J Kitajewski, and CY Wang. Wnt-1 signaling inhibits apoptosis by activating b-catenin/T cell factor-mediated transcription. The Journal of Cell Biology, 152 (1): 87-96.
  17. 2001  associated with increased adenovirus transduction efficiency and transgene expression. Cancer Gene Therapy, 8 (3): 168-175.
  18. 2001  Z You, H Ouyang, D Lopatin, PJ Polver, and CY Wang. Nuclear factor-kB- inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity. The Journal of Biological Chemistry, 276 (28): 26398-26404.
  19. 2002  Z You, D Saims, S Chen, Z Zhang, DC Guttridge, K Guan, OA MacDougald, AM Brown, G Evan, J Kitajewski, and CY Wang. Wnt-1 signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of Cell Biology, 157 (3): 429-440.PMCID:PMC2173296
  20. 2002  Q Zeng, S Chen, Z You, F Yang, TE Carey, D Saims, and CY Wang.  Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NF-kB. The Journal of Biological Chemistry, 277 (28): 25203-25208.
  21. 2002  Z You, LV Madrid, D Saims, J Sedivy, CY Wang. C-Myc sensitizes cells to TNF-mediated apoptosis by inhibiting NF-kB transactivation. The Journal of Biological Chemistry, 277 (39): 36671-36677.
  22. 2004  D. R. Haudenschild, S. M. Palmer, T. A. Moseley, Z. You, and A. H. Reddi. Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer, Cancer Res 64: 8276-8284.
  23. 2005 Z. You*, G. Duraine, J. Y. Tien, C. Lee, T. A. Moseley, and A. H. Reddi*.Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF. Biochem Biophys Res Commun 326: 624-631. (* Corresponding author)
  24. 2006 You, Z.*, Shi, X.B., DuRaine, G., Haudenschild, D., Tepper, C.G., Lo, S.H., Gandour-Edwards, R., deVere White, R.W., and Reddi, A.H. Interleukin-17 Receptor-like gene is a novel anti-apoptotic gene highly expressed in androgen independent prostate cancer. Cancer Res 66 (1):175-83. * Corresponding author)
  25. 2007 Jamali AA, Hatcher S, You Z. Donor cell survival in a fresh osteochondral allograft at twenty-nine years. A case report.J Bone Joint Surg Am. 89(1):166-9.
  26. 2007 Christina M. Lee, Damian C. Genetos, Zongbing You, Clare E. Yellowley. Hypoxia regulates PGE2 release and EP1 receptor expression in osteoblastic cells. Journal of Cellular Physiology.212 (1): 182 – 188.PMCID: PMC2929130
  27. 2007 Shintaro Yamane, Ewana Cheng, Zongbing You, and A Hari Reddi. Gene expression profiling of mouse articular and growth plate cartilage.Tissue Engineering. 13 (9): 2163 – 2173.
  28. 2007 Zongbing You*, Ying Dong, Xiangtian Kong, Yi Zhang, Robert L. Vessella, and  Jonathan Melamed.Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancer.Neoplasia.9(6):464-470. (* Corresponding author)PMCID:PMC1899256
  29. 2007 Yi Zhang, James A. Ryan, Paul E. Di Cesare, Judy Liu, Christopher A. Walsh, and Zongbing You*. Doublecortin is expressed in articular chondrocytes. Biochem Biophys Res Commun.363 (2007) 694-700.(* Corresponding author).
  30. 2008 Zongbing You*, Ying Dong, Xiangtian Kong, Laurel A. Beckett, Regina Gandour-Edwards, and Jonathan Melamed. Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival. BMC Medical Genomics 2008, 1:6 (14 February 2008)doi:10.1186/1755-8794-1-6(* Corresponding author)PMCID:PMC2254643
  31. 2008 Dongxia Ge, Zongbing You*. Expression of interleukin-17RC protein in normal human tissues.International Archives of Medicine 2008, 1:19 (17 October 2008) doi:10.1186/1755-7682-1-19 (* Corresponding author)PMCID:PMC2596096
  32. 2009 J.A. Ryan, E.A. Eisner, G. Duraine, Z. You, and A. Hari Reddi, Mechanical compression of articular cartilage induces chondrocyte proliferation and inhibits proteoglycan synthesis by activation of the ERK pathway: implications for tissue engineering and regenerative medicine. J Tissue Eng Regen Med 3 (2009) 107-16.PMCID: PMC3777713
  33. 2010 Daniel Davis, Mathew Cyriac, Dongxia Ge, Zongbing You*, and Felix H. Savoie. In-Vitro Cytotoxic Effects of Benzalkonium Chloride in Corticosteroid Injection Suspension.Journal of Bone and Joint Surgery (AM), 2010, 92:129-137(* Corresponding author). PMCID: not required
  34. 2010 Michael T. Bogatch, David G. Ferachi, Bart Kyle, Sam Popinchalk, Melanie H. Howell, Dongxia Ge, Zongbing You*, Felix H. Savoie. Is Chemical Incompatibility Responsible for Chondrocyte Death Induced by Local Anesthetics? Am J Sports Med, 38:520-526, 2010 (* Corresponding author). PMCID: not required
  35. 2010 Junliang Ma, Lunxu Liu*, Guowei Che, Nanbin Yu, Fuqiang Dai, and Zongbing You*. The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 10:112 (* Corresponding author).PMCID:PMC2851690
  36. 2010 Fuqiang Dai, Lunxu Liu*, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma and Zongbing You*. The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer. BMC Cancer 10 (2010) 220 (* Corresponding author).PMCID:PMC2880994
  37. 2011Q. Zhang, A.D. Cigan, L. Marrero, C. Lopreore, S. Liu, D. Ge, F.H. Savoie, and Z. You*, Expression of doublecortin reveals articular chondrocyte lineage in mouse embryonic limbs. Genesis 49 (2011) 75-82. PMID: 21162077 (* Corresponding author).PMCID: not required
  38. 2011 T. Lai, K. Wang, Q. Hou, J. Zhang, J. Yuan, L. Yuan, Z. You*, and M. Xi*, Interleukin 17 Induces Up-Regulation of Chemokine and Cytokine Expression Via Activation of the Nuclear Factor kappaB and Extracellular Signal-Regulated Kinase 1/2 Pathways in Gynecologic Cancer Cell Lines. Int J Gynecol Cancer (2011). 21: 1533-9. PMID: 21912264(*Corresponding author). PMCID: not required
  39. 2012 Dongxia Ge, Allen C. Gao, Qiuyang Zhang, Sen Liu, Yun Xue, and Zongbing You*. LNCaP Prostate Cancer Cells with Autocrine Interleukin-6 Expression Are Resistant to IL-6-induced Neuroendocrine Differentiation due to Increased Expression of Suppressors of Cytokine Signaling. The Prostate, 2012 Sep 1;72(12):1306-16. doi: 10.1002/pros.22479. Epub 2011 Dec 27.(* Corresponding author).PMID: 22213096. PMC3665156
  40. 2012 R. Nelson Mead,Jessica Ryu,Sen Liu,Dongxia Ge,Justin Lucas,Felix Savoie,and Zongbing You*. Supraphysiological Temperature Enhances Bupivacaine’s Cytotoxic Effects on Bovine Articular Chondrocytes in an In-vitro Study. Arthroscopy. Mar;28(3):397-404, 2012 (* Corresponding author). NIHMS 321941; PMID:22169763. PMCID: PMC3289738
  41. 2012 Sen Liu, Qing-Song Zhang,William Hester, Michael J. O’Brien,Felix H. Savoie,and Zongbing You*.HyaluronanProtects Bovine Articular Chondrocytes against Cell Death Induced by Bupivacaine under Supraphysiologic Temperatures. Am J Sports Med, 2012 June, 40 (6): 1375-1383. PMID: 22427617(* Corresponding author).NIHMSID#464283;PMC3665162.
  42. 2012 Qiuyang Zhang, Sen Liu, Dongxia Ge, Qingsong Zhang, Yun Xue, Zhenggang Xiong, Asim B. Abdel−Mageed, Leann Myers, Steven M. Hill, Brian G. Rowan, Oliver Sartor, Jonathan Melamed, Zhenbang Chen, and Zongbing You*. Interleulin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models. Cancer Research, 72 (10):2589-99, 2012, PMID: 22461511 (* Corresponding author) – featured on the cover of the May 15, 2012 issue of Cancer Res.PMC3665158
  43. 2012 Zongbing You*, Dongxia Ge, Sen Liu, Qiuyang Zhang, Alexander D. Borowsky, and Jonathan Melamed. Interleukin-17 Induces Expression of Chemokines and Cytokines in Prostatic Epithelial Cells but Does Not Stimulate Cell Growth In Vitro. International Journal of Medical and Biological Frontiers.2012, 18 (8): 629-644. https://www.novapublishers.com/catalog/product_info.php?products_id=34907&osCsid=c998e547e0a70b4f1bb138f0a23cffa6 (*Corresponding author).NIHMSID#464287
  44. 2012 William Hester, Jinnan Yang, Guo-Yong Wang, Sen Liu, Michael J. O’Brien, Felix H. Savoie,and Zongbing You*. Hyaluronan Does Not Affect Bupivacaine’s Inhibitory Action on Voltage-gated Potassium Channel Activities in Bovine Articular Chondrocytes.Adv Orthop. 2012;2012:361534. Epub 2012 Apr 22. PMID: 22577566; PMCID:PMC3346966 (*Corresponding author).
  45. 2012 Lunxu Liu, Dongxia Ge, Lin Ma, Jiandong Mei, Sen Liu, Qiuyang Zhang, Fuqiang Ren, Hu Liao, Qiang Pu, Tao Wang, and Zongbing You*. Interleulin-17 and Prostaglandin E2 Are Involved in Formation of an M2 Macrophage-dominant Microenvironment in Lung Cancer. J Thoracic Oncology, 2012 Jul; 7(7):1091-1100, PMID:22534817, PMCID: PMC3378786 (*Corresponding author).
  46. 2012 Qing-Song Zhang, Sen Liu, Qiuyang Zhang, Yun Xue, Dongxia Ge, Michael J. O’Brien, Felix H. Savoie, and Zongbing You*. Comparison of the Tendon Damage Caused by Four Different Anchor Systems Used in Transtendon Rotator Cuff Repair.Adv Orthop. 2012;2012:798521. Epub 2012 Jul 1, PMID: 22811923; PMCID: PMC3395215 (*Corresponding author)
  47. 2012 Dzugan, S.S., Savoie III, F.H.s, Field, L.D., O'Brien, M.J., You, Z. Acute radial ulno-humeral ligament injury in patients with chronic lateral epicondylitis: an observational report. J Shoulder Elbow Surg. 2012 Dec;21(12):1651-5. PMID: 22743071 PMCID: not required. (Z You contributed to the data analysis and manuscript preparation/approval)
  48. 2013 Nguyen HT, Zhuang Y, Sun L, Kantrow SP, Kolls JK, You Z, Zhuo Y, Shan B. Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture. Cancer Cell Int. 2013 Feb 14;13(1):16. [Epub ahead of print]. PMID: 23409704 (Z.You. did allograft studies and contributed Figures 1C and 1D). PMCID: PMC3626791
  49. 2013 Robert A. Pedowitz, Fabrizio Billi, Aaron Kavanaugh, Andrew Colbert, Sen Liu, Felix H. Savoie, Zongbing You. Arthroscopic surgical tools: A source of metal particles and possible joint damage. Arthroscopy,September, 29(9):1559-65. PMID 23910000, PMCID: PMC3759605
  50. 2013 Qingli Li, Mark J. Lambrechts, Qiuyang Zhang, Sen Liu, Dongxia Ge, Rutie Yin, Mingrong Xi, Zongbing You*.Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis. Drug Design, Development and Therapy, July 24, 2013, 7: 635-643.PMID: 23983455,PMCID:PMC3749059(*Corresponding author)

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