Education

Biography

Research Interest

• Prostate Cancer, Signaling Transduction, Steroid hormone, translational research

Scientific Activities

Publications

1. Singh, AP, Bafna, S, Chaudhary, K, Venkatraman, G, Smith, L, Eudy, JD, Johansson, SL, Lin, MF, and Batra, SK (2008). Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. Cancer Letters 259:28-38. 
2. Veeramani, S, Yuan, TC, Lin, FF, and Lin, MF (2008). Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells. Oncogene 2008; 27:5057-5068.
3. Dillard, PR, Lin, MF, and Khan, SA (2008). Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol 295:115-120. (PMID:1878595) 
4. Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, Ye KJ, Lin MF, Lawrenson L, Lancaster WD, Kurkinen MK, Liao JD, Gairola CG, Shekhar MP, Narayan S, Miller FR, Heng HH. (2009) Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer. J Cell Physiol 219(2):2888-300. (PMID:19115235) 
5. Radhakrishnan P, Lin MF, Cheng PW. (2009) Elevated expression of L-selectin ligand in lymph node-derived human prostate cancer cells correlates with increased tumorigenicity. Glycoconj J. 26(1):75-81. 
6. Alam S, Rajendran M, Ouyang S, Veeramani S, Li Z, Lin MF. (2009) A novel role of shc adaptor proteins in steroid hormone-regulated cancers. Endocr Relat Cancer. 16:1-16. (PMID:19001530, 2008). 
7. Zhang L, Davis JS, Zelivianski S, Lin FF, Schutte R, Davis TL, Hauke R, Batra SK, Lin MF. (2009) Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment. Cancer Lett. 285:58-65. (PMID:19467571). 
8. Veeramani S, Lee MS, Lin MF. (2009) Revisiting histidine-dependent acid phosphatases: A distinct group of tyrosine phosphatases. Trends Biochem Sci. 34:273-278. (PMID:19467874). 
9. Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin MF, Tu Y. (2009) Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene. 28(16):1853-63. (PMID:19035425)
10. Rajendran M, Thomes P, Zhang L, Veeramani S, Lin MF. (2010) p66Shc - A longevity redox protein in human prostate cancer progression and metastasis. Cancer Metastasis Rev. 29:207-222. (PMID:20111892)
11. Chuang TD*, Chen SJ*, Lin FF, Veeramani S, Kumar S, Batra SK, Tu Y, Lin MF. (2010) Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth. J. Biological Chemistry (In Press). (PMID:20498373). (*Equal contributions)

Book Chapters/Non Peer-reviewed Articles

1. Lin MF, Ou-Yang SQ, and Veeramani S. (2009) Comment: "Prostate acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine." Neuron, 9 October 2008, Volume 60, Issue 1, p. 111-122.