bettuzzi-saverio
Bettuzzi Saverio, PhD
Professor of Biochemistry and Molecular Biology

University of Parma, Parma
Italy
Phone: +39-0521-033803
E-mail:  saverio.bettuzzi@unipr.it

Education

PhD 1981 University of Bologna, Italy
University Diploma 1983 University of Bologna, Italy
Doctorate 1990 University of Bologna, Italy

Biography


Research Interest

Clusterin (CLU), Prostate Cancer (PCa), Green Tea, Catechins, Polyphenols, EGCG, Chemoprevention, Biochemistry and Molecular Biology of Cancer, Physiology and Pathology of the Prostate, Cell Growth Control, Prostate Metabolism, Androgen Action on Prostate Cells, Polyamines, Gene expression, Epigenetic Regulation of Gene Expression


Scientific Activities

  • Società Italiana di Biochimica (SIB), 1999.
  • Istituto Nazionale Biostrutture e Biosistemi (INBB), member of the Board, 2001.
  • Società di Medicina e Scienze Naturali di Parma, 2002.
  • European Society of Urological Research (ESUR), 2003; member of the Board, 2013.
  • American Association for Cancer Research (AACR), 2004.
  • European Association of Urology (EAU), 2006.
  • Centre of Molecular and Translational Oncology (COMT), Vice-President, 2008.

Publications

  1. EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism. Modernelli A, Naponelli V, Giovanna Troglio M, Bonacini M, Ramazzina I, Bettuzzi S, Rizzi F. Sci Rep. 2015 Oct 16;5:15270. doi: 10.1038/srep15270.
  2. Control of autophagy in cancer. Orzechowski A, Bettuzzi S, Pawlikowska P, Pająk B. Biomed Res Int. 2015;2015:698740. doi: 10.1155/2015/698740.
  3. Roles of autophagy induced by natural compounds in prostate cancer. Naponelli V, Modernelli A, Bettuzzi S, Rizzi F. Biomed Res Int. 2015;2015:121826. doi: 10.1155/2015/121826.
  4. Polyphenon E(R), a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Rizzi F, Naponelli V, Silva A, Modernelli A, Ramazzina I, Bonacini M, Tardito S, Gatti R, Uggeri J, Bettuzzi S. Carcinogenesis. 2014 Apr;35(4):828-39. doi: 10.1093/carcin/bgt481.
  5. Prognostic role of clusterin in resected adenocarcinomas of the lung. Panico F, Casali C, Rossi G, Rizzi F, Morandi U, Bettuzzi S, Davalli P, Corbetta L, Storelli ES, Corti A, Fabbri LM, Astancolle S, Luppi F. Lung Cancer. 2013 Mar;79(3):294-9. doi: 10.1016/j.lungcan.2012.11.024.
  6. Anticancer activity of green tea polyphenols in prostate gland. Davalli P, Rizzi F, Caporali A, Pellacani D, Davoli S, Bettuzzi S, Brausi M, D'Arca D. Oxid Med Cell Longev 2012;2012:984219. doi: 10.1155/2012/984219. 8.
  7. Health Benefits of Tea. Serafini M, Del Rio D, Yao DN, Bettuzzi S, Peluso I. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 12.
  8. Intracellular clusterin negatively regulates ovarian chemoresistance: compromised expression sensitizes ovarian cancer cells to paclitaxel. Hassan MK, Watari H, Christenson L, Bettuzzi S, Sakuragi N. Tumour Biol. 2011 Oct;32(5):1031-47. doi: 10.1007/s13277-011-0207-0.

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