Education

Biography

Dr. Zhixiang Wang, got his PhD at Simon Fraser University, Canada in 1993. He is now a full professor at the Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta. He has published more than 50 papers in reputed journals and has been serving as reviewer or board/panel members for various journal and funding agencies.

Research Interest

Cell Signalling, Receptor Endocytosis, and Human Cancer

Scientific Activities

Teaching Experience

Professional Activities

• American Society for Cell Biology
• American Society for Microbiology

Committee Assignments in the Faculty and Department:

Honors & Awards

Publications

A. Book Chapter:

1. Wang, Z. (2012) Mutual Regulation of Receptor-Mediated Cell Signalling and Endocytosis: EGF Receptor System as an Example. Page 301-330. In Molecular Regulation of Endocytosis. Ed. Ceresa, B. ISBN 978-953-51-0662-3, Hard cover, 456 pages, Publisher: InTech, Published: July 06, 2012 under CC BY 3.0 license, in subject Biochemistry, Genetics and Molecular Biology. DOI:10.5772/2989

B. Refereed Papers:

1. Wang, R., Wang, H., and Wang, Z. (2016) Live imaging to study microtubule dynamic instability in taxane-resistant breast cancers. JoVE (In Press)
2. Kourouniotis, G., Wang, Y., Pennock, S., Chen, X., and Wang, Z. (2016) Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor. Int J Mol Sci. 2016 Jul 25;17(8). pii: E1200. doi: 10.3390/ijms17081200.
3. Wang, Z. (2016) Transactivation of Epidermal Growth Factor Receptor by G Protein-coupled Receptors: Recent Progress, Challenges and Future Research. Int. J. Mol. Sci. 2016, 17(1), 95
4. Tong, J., Li, L., Ballermann, B. and Wang, Z. (2016) Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation. PLOS One 27;11(1):e0147103. doi: 10.1371
5. Tavasoli, M., Li, L., Al-Momany, A., Zhu, L., Adam, B.A., Wang, Z. and Ballermann, B. (2016) CLIC5A stimulates Rac1-dependent Pak and ERM protein activation, protecting against hypertension-induced glomerular injury. Kidney International 89(4):833-47
6. Wang, Z. (2015) Personalized medicine for HER2-positive breast cancer. Breast Cancer Management, 4(5), 237-240 , DOI 10.2217/bmt.15.16
7. Wee, P., Shi, H., Jiang, J., Wang, Y., and Wang, Z. (2015) EGF stimulates the activation of EGF receptors and the selective activation of major signaling pathways during mitosis. Cellular Signalling 27:638-51.
8. Wang, Q., Chen, X. and Wang, Z. (2015) Dimerization drives EGF receptor endocytosis through two sets of compatible endocytic codes. Journal of Cell Science 128:935-950
9. Wang, Z. (2014) Taxane resistance in Breast Cancer. (review). Cancer Cell & Microenvironment 1 (3): 57-65 doi: 10.14800/ccm.126
10. Wang H., Vo T., Hajar A., Li S., Chen X., Parissenti A. M., Brindley D.N., Wang Z. (2014): Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells. BMC Cancer, 14:37.
11. Tong, J., Li, L., Ballermann, B. and Wang, Z. (2013) Phosphorylation of Rac1 T108 by ERK in response to EGF: A novel mechanism to regulate Rac1 function. Mol. Cell. Biol. 33:4538-4551.
12. Li, L., Chakraborty, S., Yang, C., Hatanpaa, K.J., Cipher, D.J., Puliyappadamba1, V.T., Madden, A.C., Raisanen, J., Burma, S., Saha, D., Wang, Z., Pingle, S.C., Kesari, S., Boothman, D.A. and Habib, A.A. (2013) An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII. Oncogene 33(33):4253-64.
13. Wu, P. Wee, P., Jiang, J., Chen, X. and Wang, Z. (2012) Differential regulation of transcription factors by location-specific activation of EGF receptor signalling via a spatio-temporal interplay of Erk activation. PLOS ONE 7 (9) e41354: 1-18
14. Chen C., Uludag H., Wang Z., Jiang H. (2012) Noggin suppression decreases BMP-2-induced osteogenesis of human bone marrow-derived mesenchymal stem cells in vitro. J Cell Biochem. 113(12):3672-80. doi: 10.1002/jcb.24240
15. Chen C., Uludag H., Wang Z., Rezansoff A., Jiang H. (2012) Microphages inhibit migration, metabolic activity and osteogenic differentiation of human mesenchymal stem cells in vitro. Cells Tissues Organs 195(6):473-83.
16. Liu, L., Shi, H., Chen, X. and Wang, Z. (2011) Regulation of EGF Receptor Endocytosis during Mitosis. Traffic 12: 201-217.
17. Pahara, J., Shi, H., Chen, X. and Wang, Z. (2010) Dimerization Drives PDGF Receptor Endocytosis through a C-terminal Hydrophobic Motif Shared by EGF Receptor. Exp. Cell Res 15: 2237-50.
18. Li, S, Wang, Q, Wang,Y. Chen, X. and Wang, Z. (2009) PLC-γ1 and Rac1 co-regulates EGF-induced cytoskeleton remodelling and cell migration. Molecular Endocrinology 23: 901-913.
19. Pennock, S. and Wang, Z. (2008) A Tale of Two Cbls: Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation. Mol. Cell. Biol. 28: 3020-3037.
20. Wang, Q., Wu, F., and Wang, Z. (2007) Identification of EGF Receptor C-terminal Sequences 1005-1017 and Di-leucine Motif 1010LL1011 as Essential in EGF Receptor Endocytosis. Exp. Cell Res. 313: 3349-3363.
21. Wang, Y., Wu, J. and Wang, Z. (2006) Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor. Mol. Biol. Cell 17: 2267-2277.
22. Wang, Q., Villeneuve, G., and Wang, Z. (2005) Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. EMBO Rep., 6: 942-948.
23. Wang, Y., Pennock, S., Chen, X., Kazlauskas, A. and Wang, Z. (2004) PDGF receptor-mediated signal transduction from endosomes. J. Biol. Chem. 279: 8038-8046
24. Wang, Y. and Wang, Z. (2003) Regulation of EGF-induced phospholipase C-γ1 translocation and activation by its SH2 and PH domains. Traffic 4: 618-630
25. Pennock, S. and Wang, Z. (2003) Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling. Mol. Cell. Biol. 23: 5803-5815
26. Wang Y, Pennock S, Chen X. and Wang Z. Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Sci. STKE 2002(161): PL17.
27. Wang, Y., Pennock, S, Chen, X. and Wang, Z. (2002) Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol. Cell. Biol. 22 (20): 7279-7290 [Cover illustration on MCB 22 (22)]. Science's STKE highlighted this paper in "This Week in Signal Transduction" for the October 1 issue.
28. Wang, Z. and Moran, M. (2002) Phospholipase C-γ1: a Phospholipase and Guanine Nucleotide Exchange Factor. Molecular Intervention 2: 352-355
29. Chen, X. and Wang, Z. (2001) Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase. EMBO Reports 2: 842-849.
30. Chen, X. and Wang, Z. (2001) Regulation of EGF receptor intracellular trafficking by Rab5 in the absence of Phosphatidylinosito 3-kinase activity. EMBO Reports 2:68-74. (with Cover Illustration)
31. Dankort, D., Maslikowski, B., Warner, N., Kanno N. Kim, H., Wang, Z., Moran, M.F., Oshima, R.G., Cardiff, R. D. and Muller, W. (2001) Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer. Mol. Cell. Biol. 21: 1540-1551.
32. Chen, X., Yeung, K. T. and Wang, Z. (2000) Enhanced drug resistance in cells coexpressing ErbB2 with EGFR or ErbB3. Biochem. Biophys. Res. Commun. 277: 757-763.