michael-thompson
Michael Thompson, PhD
Professor of Bioanalytical Chemistry

Education

1986 DSc University of Wales, UK
1970 PhD in Analytical Chemistry McMaster University, Canada
1966 BSc Honors in Chemistry University of Wales, UK

Biography

Professor Michael Thompson obtained his undergraduate degree from the University of Wales, UK and his PhD in analytical chemistry from McMaster University. Following a period as Science Research Council PDF at Swansea University he was appointed Lecturer in Instrumental Analysis at Loughborough University. He then moved to the University of Toronto where he is now Professor of Bioanalytical Chemistry. He has held a number of distinguished research posts including the Leverhulme Fellowship at the University of Durham and the Science Foundation Ireland E.T.S Walton Research Fellowship at the Tyndall National Institute, Cork City. He is recognized internationally for his pioneering work over many years in the area of research into new biosensor technologies and the surface chemistry of biochemical and biological entities. He has made major contributions to the label-free detection of immunochemical and nucleic acid interactions and surface behavior of cells using ultra high frequency acoustic wave physics. Recently, scanning Kelvin nanoprobe detection has been introduced which offers the multiplexed detection of biochemical phenomena.

Thompson has served on the Editorial Boards of a number of major international journals including Analytical Chemistry, The Analyst, Talanta, Analytica Chimica Acta and Biosensors and Bioelectronics. He is currently Editor-in-Chief of the monograph series “Detection Science” for the Royal Society of Chemistry, UK. He has been awarded many prestigious international prizes for his research including The Robert Boyle Gold Medal of the Royal Society of Chemistry, E.W.R. Steacie Award of the Chemical Society of Canada, the Theophilus Redwood Award of the Royal Society of Chemistry and the Fisher Scientific Award in Analytical Chemistry of the Chemical Society of Canada. He was made a Fellow of the Royal Society of Canada in 1999.

Research Interests

  • Development of new techniques in bioanalytical chemistry.
  • New technologies for clinical diagnostics and drug discovery.
  • Nanotechnology, Molecular Imaging & Systems Biology.

Scientific Activities

Teaching Experience
2015-Present Tyndall Academic Associate, Tyndall National Institute, Cork City, Republic of Ireland
2011-2015 Tyndall Academic Visitor, Tyndall National Institute, Cork City, Republic of Ireland.
2001-present Associate Member, Institute for Biomaterials and Biomedical Engineering, University of Toronto
2001 Visiting Professor, Sector of Medicine, Faculty of Experimental Sciences, Scuola Superiore di Studi Universitare e di Perfezionamento, Sant’ Anna, Pisa, Italy
2000-2001 Distinguished Academic Visitor, Queen’s College and Visiting Scholar, Institute of Biotechnology, University of Cambridge, UK
1999-2005 Consultant, Research Institute, The Hospital for Sick Children, Toronto
1998-present Chairman, Scientific Advisory Board, Maple Biosciences
1994 Visiting Scientist, Department of Molecular Biology, Scripps Research Institute, La Jolla, Canada, USA
1989-1997 Staff Research Scientist, Max Bell Research Center, Toronto General Hospital, Toronto
1987 Professor (Visiting), Institut fur Physik, Universitat der Bundeswehr, Munchen, Germany
1983-1984 Professor (Visiting), Department of Bioengineering, University of Utah, Salt Lake City, Utah
1982-present Professor, Analytical Chemistry, University of Toronto
1978-1982 Associate Professor, Analytical Chemistry, University of Toronto
1975-1978 Assistant Professor, Analytical Chemistry, University of Toronto, Appointment to Graduate School
1971-1975 Lecturer in Instrumental Analysis, University of Technology, Loughborough, UK
1970-1971 Post-Doctoral Fellow, University College of Swansea
1966-1970 Graduate Student, McMaster University
1962-1966 Undergraduate in Chemistry, University College of Swansea
1958-1962 Laboratory Assistant, Industrial Hygiene Research Facility, Swinden Laboratories, British Steel Corporation, Rotherham, UK
Professional Activities

MEMBERSHIP FOR PROFESSIONAL ORGANIZATIONS:

  • Canadian Institute of Chemistry
  • Royal Society of Chemistry, UK
  • International Society for Electrochemistry
  • Canadian Institute for Neutron Scattering
  • American Chemical Society
  • IEEE, Canada Branch
Honors & Awards
2014 The David Ling Prize (with Sonia Sheikh). International Conference on the Chemistry, Physics and Biology of Water, Pamporovo, Bulgaria
2014 The Elsevier 2014 Biosensors and Bioelectronics Award (2nd Prize)
2013 Fellow of the Institute for Biophysics, University of Durham, UK
2007 The Science Foundation of Ireland ETS Walton Award, Tyndall National Institute, Cork, Republic of Ireland
2004 The 2004 Elsevier Biosensors and Bioelectronics Award
2004 EWR Steacie Award, Canadian Society for Chemistry
2003-2005 Leverhulme Trust Visiting Professorship, University of Durham, UK
2002 The Robert Boyle Gold Medal of the Royal Society Chemistry
2000 Elected Distinguished Academic Visitor, Queens’ College, University of Cambridge
1998 Royal Society of Chemistry Award for Chemical Analysis and Instrumentation
1998 Fellow of the Royal Society of Canada (Academy III)
1998 Varian Lectureship in Analytical and Environmental Chemistry, Ottawa-Carleton Chemistry Institute, Ottawa
1997 The University Lectureship, Concordia University, Montreal
1996 Dow Lectureship in Analytical Chemistry, University of British Columbia
1995 Theophilus Redwood Lecture Award of the Royal Society of Chemistry, UK
1992 Xerox Lecturer, University of Windsor
1989 Fisher Scientific Lecture Award, Canadian Society for Chemistry
1985 Chemical Institute of Canada Atlantic Region Lecturer
1982 Ontario Confederation of University Faculty Associations (OCUFA) Teaching Award
1980 Fellow of Canadian Institute of Chemistry
1975 Fellow of the Royal Society of Chemistry, UK
1970-1971 Science Research Council (UK) Post Doctoral Fellowship
1968-1970 International Nickel Company of Canada Graduate Research Fellowship
1968 Natural Sciences and Engineering Research Council of Canada Scholarship
1966-1968 Ontario Graduate Fellowship

Publications

  1. Salari and M. Thompson, “Recent advances in AC electrokinetic technology for biosensor development”, Sensors and Actuators B: Chemical, submitted.
  2. R. R. Ravindranath, I. Yougbare, H. Ni, J. E. Fish, A. Romaschin and M. Thompson,, “Application of a biologically active surface coating towards coronary stent devices”, Journal of Materials Chemistry B, submitted.
  3. N. R. Tanguy, Michael Thompson and N. Yan, “Recent Advances in the Application of Polyaniline in Ammonia Detection Sensors,” Sensors and Actuators B: Chemical, reviews in.286.
  4. De La Franier, A. Jankowski, M. Thompson, “Functionalizable self-assembled trichlorosilyl-based monolayer for application in biosensor technology”, Applied Surface Science, in press.
  5. S, Cheung and M. Thompson, “On the acoustic wave sensor response to immortalized hypothalamic neurons at the device-liquid interface”, Sensing and BioSensing Research, 11, 113 (2016).
  6. J.B. Chen, M.A.D. Neves and M. Thompson, “Biosensor surface attachment of the ovarian cancer biomarker HSP10 via His-tag modification”, Sensing and BioSensing Research, 11, 107 (2016).
  7. R. Machado, N. Soltani, S. Dufour, M. T. Salam, P. L. Carlen, R. Genov and M. Thompson. “Antifouling impedimetric sensor for the spatial measurement of potassium during epileptic seizures”, Biosensors, 6, 53 (2016).
  8. V. Crivianu-Gaita and M. Thompson, “Aptamers, antibody scFv, and antibody Fab' fragments: An overview and comparison of three of the most versatile biosensor biorecognition elements”, Biosensors and Bioelectronics, 85, 32 (2016).
  9. S. Sheikh, C. Blaszykowski and M. Thompson, “Endotoxin detection in full blood plasma in a theranostic approach to combat sepsis”, RSC Advances, 6, 38037 (2016).
  10. de los Santos Pereira, S. Sheikh, C. Blaszykowski, O.Pop-Georgievski, K. Fedorov, M. Thompson and C. Rodriguez-Emmenegger, “Antifouling polymer brushes displaying antithrombogenic surface properties”, Biomacromolecules, 17, 1179 (2016).
  11. M.A.D. Neves, C. Blaszykowski and M. Thompson, “Utilizing a key aptamer structure-switching mechanism for cocaine detection”, Analytical Chemistry, 88, 3098 (2016).
  12. V. Crivianu-Gaita, M. Aamer, R.T. Posaratnanathan, A. Romaschin; and M. Thompson “Acoustic wave biosensor for the detection of the breast and prostate cancer metastasis biomarker protein PTHrP”, Biosensors and Bioelectronics, 78, 92 (2016).
  13. V. Crivianu-Gaita, A. Romaschin, and M. Thompson, “Anti-fouling properties of Fab' fragments immobilized on silane-based adlayers”, Applied Surface Chemistry, 359, 21 (2015).
  14. R. R Ravindranath, A. Romaschin; and M. Thompson, “In vitro and in vivo cell-capture strategies using cardiac stent technology - a review”, Clinical Biochemistry, 49, 186 (2016).
  15. K. Fedorov, A. Jankowski, S. Sheikh, C. Blaszykowski, A. Reheman, A. Romaschin, H. Ni, and M. Thompson, “Prevention of surface-induced thrombogenesis on poly(vinyl chloride)”. Journal of Materials Chemistry, B, 3, 8623 (2015).
  16. Blaszykowski, S. Sheikh and M. Thompson, “A Survey of state-of-the-art surface chemistries to minimize fouling from human and animal biofluids”, Biomaterials Science”, 3, 1335 (2015).
  17. P. Benvenuto, M.A.D. Neves, C. Blaszykowski,A. Romaschin, T. Chung, S-R. Kim and M. Thompson , “Adlayer-mediated Antibody Immobilization to Stainless Steel for Potential Application to Endothelial Progenitor Cell Capture” Langmuir, 31, 5423 (2015).
  18. M.A.D.Neves, C. Blaszykowski, S. Bokhari and M. Thompson, “Ultra-high frequency piezoelectric aptasensor for the detection of cocaine”, Biosensors and Bioelectronics, 72, 383 (2015).
  19. V. Crivianu-Gaita and M. Thompson, “Immobilization of Fab fragments onto substrate surfaces: A survey of methods and applications”, Biosensors and Bioelectronics, 70, 167 (2015).
  20. V. Crivianu-Gaita, A. Romaschin and M. Thompson, “High efficiency reduction capability for the formation of Fab antibody fragments from F(ab)2 units”, Biochemical and Biophysical Research Reports, 2, 23 (2015).
  21. R. Machado, C. Blaszykowski, S. Sheikh, Y. Suganuma and M. Thompson, “Ultrathin surface chemistry to delay anion fouling”, ChemPlusChem.
  22. S. Sheikh, C. Blaszykowski, D. Thompson and M. Thompson, “On the hydration of subnanometric antifouling organosilane adlayers: a molecular dynamics simulation”, Journal of Colloid and Interface Science, 437, 197 (2015).
  23. M. Thompson, C. Blaszykowski, S. Sheikh and A. Romaschin, “A true theranostic approach to medicine: towards tandem sensor detection and removal of endotoxin in blood”, Biosensors and Bioelectronics, 67, 3 (2015).
  24. Mihai, A. Vezeanu, C. Polonschii, S. David, S. Gaspar, B. Bucur, C. Blasyzkowski, S. Sheikh, M. Thompson and A. Vasilescu, “Low fouling SPR detection of lysozyme and aggregates”, Analytical Methods, 6, 7646 (2014).
  25. L-E. Cheran, A. Cheran and M. Thompson, “Biomimicry and materials in medicine” in “Advanced Synthetic Materials in Detection Science”, (Ed. S. Reddy), RSC Publishing, Cambridge, UK, 2014.
  26. Fedorov , C. Blaszykowski , S. Sheikh , A. Reheman , A. Romaschin , H. Ni and M Thompson, “Prevention of thrombogenesis from whole human blood on plastic polymer by ultrathin monoethylene glycol silane adlayer”, Langmuir, 30, 3217 (2014).
  27. N.M. Pawlowska, H. Fritzsche, M. Vezvaie, C. Blaszykowski, S. Sheikh and M. Thompson, “Probing the hydration of ultra-thin antifouling silane adlayers using neutron reflectometry”, Langmuir, 30, 1199, 2014.
  28. M. Thompson, S. Sheikh and C. Blaszykowski, “A perspective on the application of biosensor and lab-on-a-chip technologies to biomarker detection in biological fluids”, Austin Journal of Nanomedicine and Nanotechnology, 1, 2 (2014).
  29. N. Crawley, A. Romaschin and M. Thompson, “Theranostics in the growing field of personalized medicine: an analytical chemistry perspective”, Analytical Chemistry, 86, 130 (2014).
  30. Blaszykowski, S. Sheikh and M. Thompson, “Biocompatibility and antifouling: is there really a link”, Trends in Biotechnology, 32, 61 (2014).
  31. U.J. Krull and M. Thompson, “Analytical Chemistry”, In: Reedijk, J. (Ed.), Reference Module in Chemistry, Molecular Sciences and Chemical Engineering., Elsevier. Waltham, MA 2013.
  32. M. Thompson, S. Sheikh, C Blaszykowski and A. Romaschin, “Biosensor technology and the clinical biochemistry laboratory – issue of signal interference from the biological matrix”, in “Detection Challenges in Clinical Diagnostics”, (Eds. P. Vadgama and S.F. Peteu), RSC Publishing, Cambridge, UK, 2013.
  33. S. Sheikh, C. Blaszykowski and M. Thompson, “Sacrificial BSA to block non- specific adsorption on organosilane adlayers in ultra-high frequency acoustic wave sensing, Surface and Interface Analysis, 45, 1781 (2013).
  34. Chan, N. Jackson, A. Mathewson, P. Galvin, C. Blaszykowski1, A.B. Alamin Dow, N.P. Kherani and M. Thompson, “Surface modification of aluminum nitride with functionalizable organosilane adlayers for ultra-high frequency acoustic wave seniors”, Applied Surface Science, 282, 709 (2013).
  35. E. Y. L. Chak, N. M. Pawlowska, C. Blaszykowski, M. Thompson, “Scanning Kelvin probe study of photolabile silane surface modification of indium tin oxide ”, Surface and Interface Analysis, 45, 1347 (2013).
  36. C. Avci, S Sheikh, C. Blaszykowski and M. Thompson, “Critical role of surface hydration on the dynamics of serum adsorption studied with monoethylene glycol adlayers on gold”, Chemical Communications, 49, 466 (2013).
  37. Nazneen, G. Herzog, W.M D. Arrigan, N. Caplice, P. Benvenuto, M. Thompson and P. Galvin “Surface chemical and physical modification in stent technology for the treatment of coronary artery disease”, Journal of Biomedical Materials Research, B. 100, 1989 (2012).
  38. C. Blaszykowski, S. Sheikh and M.Thompson, “Surface chemistry to minimize fouling from blood-based fluids”, Chemical Society Reviews, 41, 5599 (2012).
  39. C. Blaszykowski, S. Sheikh, P. Benvenuto and M. Thompson, “New functionalizable alkyltrichlorosilane surface modifiers for biosensor and biomedical applications”, Langmuir, 28, 2318 (2012).
  40. S. Sheikh, D. Y. Yang, C. Blaszykowski and M. Thompson, ”Single ether group in glycol-based ultra-thin layer monolayer prevents surface fouling from undiluted serum”, Chemical Communications, 48, 1305 (2012).
  41. S. Sadeghi and M. Thompson, “Electrochemistry, emergent patterns and inorganic intelligent Response”, in Molecular and Supramolecular Information Processing: From Molecular Switches to Unconventional Computing, D. E. Katz, Wiley-VCH, Weinheim, Germany, 2012, P. 305.
  42. C. Blaszykowski, L.-E. Cheran and M. Thompson, “Modulation of indium-tin oxide work function by versatile self-assembled monolayer measured by scanning Kelvin nanoprobe”, Canadian Journal of Chemistry, 89, 1502 (3011).
  43. Nazneen, P. Galvin, D. Arrigan, M. Thompson, P. Benvenuto and G. Herzog, “Electropolishing of medical-grade stainless steel in preparation for surface nano-texturing”, Journal of Solid State Electrochemistry, 16, 1389 (2012).
  44. S. Cheung, L.J. Fick, D. D. Belsham and M. Thompson, “Synchronization of the circadian rhythm generator and the effects of glucagon on hypothalamic mouse neurons detected by coustic wave propagation”, Analyst, 136, 2786 (2011).
  45. S. Cheung, L. J. Fick, D. D. Belsham, D.A.: Lovejoy and M. Thompson, “" Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation ”, Analyst, 136, 4412 (2011).
  46. S. Sheikh, C. Blaszykowski and M. Thompson, “Label-free detection of HIV-2 antibodies in serum with an ultra-high frequency acoustic wave sensor”, Talanta, 85, 816 (2011).
  47. Detection of acute brain injury by Raman spectral signature, L-L.Tay, R. G. Tremblay, J. Hulse, B. Zurakowski, M. Thompson and M. Bani-Yaghoub, Analyst, 136, 1620 (2011).
  48. S. Sadeghi, W.A. MacKay and M. Thompson, “Algorithm for online detection of signal patterns using phase synchrony: an application to an electrode array”, Measurement Science and Technology, 22, 025802 (2011).
  49. J.S. Ellis and M. Thompson, “Conformational states of nucleic acid-peptide complexes monitored by acoustic wave propagation and molecular dynamics simulation”, Chemical Science, 2, 237 (2011).
  50. S. Sadeghi and M. Thompson, “Towards information processing from chemistry: a synthetic electrochemical cognitive system”, BioSystems, 102, 99 (2010).
  51. J.S. Ellis and M Thompson, “Viscoelastic modelling with interfacial slip of a protein monolayer electrode-adsorbed on an acoustic wave biosensor”, Langmuir, 26, 11558 (2010).
  52. S. Sheikh, J. C-C. Sheng, C. Blaszykowski and M. Thompson, “Oligoethylene glycol self-assembled monolayer chemistry combined with ultra-high frequency acoustic wave biosensor for the detection of biochemical interactions”, Chemical Science, 1, 271 (2010).
  53. S. Sadeghi and M. Thompson, “Temporal patterns and oscillatory voltage perturbation during an electrochemical process”, Physical Chemistry Chemical Physics, 12. 6795 (2010).
  54. T. Hianik, X. Wang, V. Tashlitsky, T. Oretskaya, S. Ponikova, M. Antalík, J.S. Ellis and M. Thompson, “Interaction of cationic surfactants with DNA detected by spectroscopic and acoustic wave techniques”, Analyst, 135, 980 (2010).
  55. M. Thompson, J.S. Ellis, T. Ryan and E-L. Lyle, ”Modulation of acoustic coupling by photo-oxidation of self-assembled monolayers”, Analytical Letters, 43, 1801 (2010).
  56. S. Cheung, L. Fick, D. D. Belsham and M. Thompson, “Depolarisation of surface- attached hypothalamic mouse neurons studied by acoustic wave detector”, Analyst, 135: 289 (2010).
  57. J.S. Ellis, S.Q. Xu, X. Wang, G. Herzog, D.W.M. Arrigan and Michael Thompson, “Interaction of surface-attached hemoglobin with hydrophobic anions monitored by on-line acoustic wave detector”, Bioelectrochemistry, 79, 6 (2010).

     
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