Associate Professor of Pharmacology
-
Duquesne University Mylan School of Pharmacy
Pittsburgh, Pennsylvania, USA
Phone: (412) 396-6358
E-mail: cavanaughj@duq.edu
Education
| 1997 | PhD | Pennsylvania State University College of Medicine, Hershey, PA, USA |
| 1991-1992 | BA | Franklin and Marshall College, Lancaster, PA, USA |
Biography
Dr. Jane Elizabeth Cavanaugh has a diverse background in the pharmacology, with training in in vivo and in vitro models of aging and intracellular signaling. Her graduate training focused on the neurobiology of the serotonergic system in the CNS using in vivo extracellular electrophysiological and in situ hybridization techniques. As a postdoctoral fellow at the University of Washington, she broadened her training to include in vitro models of cell death with an emphasis on primary cultures and cell signaling pathways. During this time, she was the first to characterize the role of a novel mitogen-activated protein kinase (MAPK) signaling pathway, extracellular signal-regulated kinase 5 (ERK5) in neuronal survival and described the regulation of the pathway during brain development. At the University of Pittsburgh, she combined her expertise with in vivo and in vitro models to further explore alterations in the MAPK pathways. As PI or co-Investigator on several previous university- and NIH-funded grants, including a K01 award, she was able to define a role for ERK5 in dopaminergic neuronal survival and began to characterize the cellular events that underlie age-related neurodegeneration with normal and diseased aging. Since moving to Duquesne University in December 2006, she has broadened her research interests to include cancer cell biology. To this end, she received an R15 from the NCI to investigate the role of the ERK5 pathway in breast cancer cell models, both in vitro and in vivo. In summary, she has extensive training and successful research projects involving in vitro and in vivo models and cell signaling, specifically ERK5 pathway regulation, and long time interest and experiences in the signaling research area.
Research Interests
- Cancer cell biology
- Neurobiology and Cancer biology of aging
Scientific Activities
Teaching Experience
| 2015-Present | Associate Professor of Pharmacology, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA, USA |
| 2006-2015 | Assistant Professor of Pharmacology, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA, USA |
| 2002-2006 | Research Assistant Professor, University of Pittsburgh, Pittsburgh, PA, USA |
| 2000 - 2002 | Postdoctoral Fellow, University of Washington, Seattle, WA, USA |
| 1997 - 2000 | Postdoctoral Fellow, NIA Training Grant, University of Washington, Seattle, WA, USA |
| 1994 - 1997 | NIA Interdisciplinary Training Grant on Aging, Fellowship, Pennsylvania State University Gerontology Center, PA, USA |
Professional Activities
| 2016-Present | Member, AACP Research and Graduate Affairs Committee |
| 2015-Present | Faculty Senate Representative, Duquesne University |
| 2015-Present | Member, AACP SIG on graduate education |
| 2014 | Speaker, Bethel Park High School, Pittsburgh, PA, USA |
| 2013-Present | Girl Scouts of Western PA, co-leader |
| 2012-Present | American Association of Cancer Research |
| 2007-Present | American Association of Colleges of Pharmacy |
| 2004-Present | Faculty for Undergraduate Neuroscience |
| 1996-1998 | Middle-Atlantic Pharmacological Society, Member |
| 1994-1997 | American Society for Pharmacology and Experimental Therapeutics, Member |
| 1994-Present | Society for Neuroscience, Member |
Patents
1. U.S. Patent Application Serial No. 14/081,426
Entitled: Carboxylic Acid Ester Prodrug Inhibitors of MEK
File No. 049450-00285-1 (00288)
2. U.S. Patent Application No. 15/021,592
PCT International Patent Application No. PCT/US2014/055143
Title: Novel Anthranilic Amides and the Use Thereof
Honors & Awards
| 2015 | Duquesne University Office of Research Hall of Fame Inductee |
| 2014, 2015 | First Place poster award, University of Pittsburgh Aging Institute Research Symposium |
| 2010 | Molecular Biology of Aging Course Participant, Marine Biological Laboratories, Woods Hole, MA |
| 2004 | Travel Award Fellowship, 37th Winter Conference on Brain Research |
| 2003 | National Institute on Aging, 2003 Summer Institute on Aging Research, Participant - 1 of 43 participants chosen to attend workshop |
| 1998 | Graduate Student Commencement Speaker, Pennsylvania State College of Medicine |
| 1996 | Middle-Atlantic Pharmacological Society Spring Meeting, Poster Competition, First Place |
| 1996 | Graduate Research Exhibition, Pennsylvania State University, Poster Competition, Third Place, Life Science Division |
| 1996 | ASPET Student Travel Award for Experimental Biology |
| 1995-1997 | Dissertation Study Animals Award, National Institute on Aging |
| 1995-1996 | Alumni Endowed Scholarship, Pennsylvania State University |
Publications
- J.N. Spencer, J.E. Mihalick, T.J. Nicholson, P.A. Cortina, J.L. Rinehimer, J.E. Smith, Xiaoming Ke, Qing He, S.E. Daniels, S. Puppala, J.L. Ealy, L.J. Fenton, W.J. Nicholson, I.M. Paul, C.H. Yoder. Comparison of Macrocyclic Effect for Ether Hosts in Aqueous and Organic Solvents. J. Phys. Chem. 97:10509-10512, 1993.
- J.E. Smith, J.M. Lakoski. Electrophysiological effects of fluoxetine and duloxetine in the dorsal raphe nucleus and hippocampus. Eur. J. Pharm. 323: 69-73, 1997.
- J.E. Smith, J.M. Lakoski. An electrophysiological study of the effects of the reuptake inhibitor duloxetine on serotonergic responses in the aging hippocampus, Pharmacology. 55: 66-77, 1997.
- J.E. Smith, J.M. Lakoski. Cellular electrophysiological effects of chronic fluoxetine and duloxetine administration on serotonergic responses in aging hippocampus. Synapse, 30: 318-328, 1998.
- L.W. Maines, B.J. Keck, J.E. Smith, J.M. Lakoski. Corticosterone regulation of serotonin transporter and 5-HT1A receptor expression in the aging brain. Synapse, 32: 58–66, 1999.
- M. Hetman, K. Kanning, J.E. Cavanaugh, Z. Xia. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-related kinase and phosphatidylinositol-3-kinase. J. Biol. Chem., 274: 22569-22580, 1999. 11
- M. Hetman, J.E. Cavanaugh, D. Kimelman, Z. Xia. Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal. J. Neurosci., 20(7): 2567-2574, 2000.
- J.E. Cavanaugh, J. Ham, M. Hetman, S. Poser, C. Yan, Z. Xia. Differential regulation of mitogen activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity and cAMP in neurons. J. Neurosci., 21(2): 434-443, 2001.
- L. Liu*, J.E. Cavanaugh*, Y. Wang, H. Sakagami, Z. Moa, Z. Xia. ERK activation of MEF2-mediated gene expression plays a critical role in BDNF-mediated survival of developing but not mature cortical neurons. Proc. Nat. Acad. Sci., 100(14): 8532-8537, 2003. *these authors contributed equally
- J.E. Cavanaugh, J.D. Jaumotte, J.M. Lakoski, M.J. Zigmond. Neuroprotective role of ERK1/2 and ERK5 in dopaminergic cells under basal conditions and in response to oxidative stress. J. Neurosci. Res., 84(6): 1367-1375, 2006.
- E. Lin, J.E. Cavanaugh, R.K. Leak, R.G. Perez, M.J. Zigmond. Rapid activation of ERK by 6-hydroxydopamine promotes survival of a dopaminergic cell. J. Neurosci. Res., 86: 108-117, 2008.
- P.T Flaherty, I. Chopra, P. Jain, S. Yi, E. Allen, J. Cavanaugh. Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway. Bioorg. Med. Chem. Lett., 20: 2892-2896, 2010. PMID: 20382528
- P.T Flaherty, I. Chopra, P. Jain, D. Monlish, J. Cavanaugh. Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway. Bioorg. Med. Chem. 15: 8054-8060, 2010. PMID: 20965737.
- E.N. Allen, K.M. Carlson, M.J. Zigmond, J.E. Cavanaugh. L-DOPA reverses motor deficits associated with normal aging in mice. Neurosci. Lett., 489: 1-4, 2011. PMID: 21111775
- M.S. Parmar, J.D. Jaumotte, S.L. Wyrostek, M.J. Zigmond, J.E. Cavanaugh. The role of ERK1, 2, and 5 in dopamine neurons survival during aging. Neurobiol. Aging, 35; 669-679, 2014.
- E.N. Allen, J. E. Cavanaugh. Loss of motor coordination in an aging mouse model. Behav. Brain Res., 267C: 119–125, 2014.
- K.M. Rose, M.S. Parmar, J. E. Cavanaugh. Dietary supplementation with resveratrol protects against striatal dopaminergic deficits produced by in utero LPS exposure. Brain Res., 1573: 37-43, 2014. doi: 10.1016/j.brainres.2014.05.028. PMID:24863468
- M.S. Parmar, J.D. Jaumotte, M.J. Zigmond, J.E. Cavanaugh. ERK1, 2, and 5 expression and activation in dopaminergic brain regions during postnatal development. Int. J. Dev. Neurosci., 46: 44-50, 2015. doi: 10.1016/j.ijdevneu.2015.06.009. PMID: 26363522
- D.M. Vasa, I.S. Buckner, J.E. Cavanaugh, P.L. Wildfong. Improved flux of Levodopa via direct deposition of solid microparticles on nasal tissue. AAPS Pharm Sci Tech. 2016 Jul 5. [Epub ahead of print] PMID:27380436
- M. Herneisey, J. Williams, J. Mirtic, L. Liu, S. Potdar, C. Bagia, J.E. Cavanaugh, J.M. Janjic. Development and characterization of resveratrol nanoemulsions carrying dual imaging agents. Ther Deliv. 7:795-808, 2016. PMID:27834615
