Chang Gong, PhD
Associate Professor of Breast Surgery
  • Sun Yat-Sen University
    Guangzhou, China
    Phone: +86-20-81332783, +86-13925089353


2009-2010 Postdoctoral INSERM U756, Paris, France
2007-2010 PhD of Experimental Breast Surgery Breast Tumor Center, Sun Yat-Sen University, Guangzhou, China
2001-2004 MD in Breast Surgery Breast Tumor Center, Sun Yat-Sen University, Guangzhou, China
1996-2001 Bachelor of Clinical medicine, Breast Surgery Sun Yat-Sen University, Guangzhou, China


Dr. Chang Gong has completed her MD in 2004 and PhD in 2010 from Sun Yat-Sen University as well as postdoctoral studies from INSERM, France. She is currently working as an associate professor of breast surgery in Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University. She focuses on the mechanisms of drug resistance and metastasis of breast cancer. She has published 15 papers in reputed journals.

Research Interests

  • Breast Cancer, Breast cancer metastasis suppressors, Cancer

Scientific Activities

Teaching Experience

2004-2006   Resident in Surgery, SunYat-Sen Memorial Hospital, SunYat-Sen University, Guangzhou, P.R.China

2011-Present Associate professor, Breast tumor center, Sun Yat-Sen University, Guangzhou, China
2007-2011 Attending surgeon, Breast tumor center, Sun Yat-Sen University, Guangzhou, China
2006-2007 Chief resident in Surgery, Sun Yat-Sen University, Guangzhou, China
2004-2006 Resident in Surgery, Sun Yat-Sen University, Guangzhou, China
Professional Activities
2011 Member, Guangdong Province Doctor Association
Honors & Awards
2014 Distinguished Young Scholar, Guangdong Province, China
2014 Science and technology award of Guangdong province
2013 Natural Science award of Ministry of Education, China
2012 Science and technology star of Zhujiang, Guangzhou City, China
2012 New Century Excellent Scholar, Ministry of Education, China


  1. Su F, Hu X, Jia W, Gong C, Song E, Hamar P. Glutathion S Transferase Pi indicates chemotherapy resistance in breast cancer. Journal of Surgical Research 2003; 13:102-8.
  2. Su F, Ouyang NY, Zhu P, Ouyang NT, Jia W, Gong C, Ma X, Xu H, Song E. Psychological stress induces chemotherapeutic resistance in breast cancers via upregulating mdr1. Biomedical and Biophysical Research Communications 2005; 329: 888-97.
  3. Gong C, Song E, Jia W, Qin L, Guo J, Jia H, Hu X, Su F. A double-blind randomized controlled trial of toremifen therapy for mastalgia. Archives of Surgery 2006; 141: 43-7.
  4. Hu X, Su F, Qin L, Jia W, Gong C, Yu F, Guo J, Song E. Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo. Biochemical and Biophysical Research Communications 2006; 346: 776-85.
  5. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E. let-7 regulates self-renewal and tumorigenesis of breast cancer cells. Cell 2007; 131:1109-23.
  6. Gong C, Yao H, Liu Q, Chen J, Shi J, Su F, Song E. Markers of tumor-initiating cells predict chemoresistance in breast cancer. PLoS One 2010; 5(12): e15630.
  7. Chen J, Yao Y, Gong C, Yu F, Sun S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Sun F, Karen S. Anderson, Liu Q, Mark E. Ewen, Yao X, Song E. CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3. Cancer Cell 2011; 19(4), 541–555.
  8. Chen SF, Gong C, Luo M, Yao HR, Zeng YJ, Su FX. Ubc9 expression predicts chemoresistance in breast cancer. Chin J Cancer. 2011 Sep; 30(9):638-44.
  9. Gong C, Yao Y, Wang Y, Liu B, Wu W, Chen J, Su F, Yao H, Song E. Upregulation of MIR-21 mediates resistance to trastuzumab therapy for breast cancer. Journal of Biological Chemistry 2011; 286(21): 19127-37.
  10. Zhu Y, Yu F, Jiao Y, Feng J, Tang W, Yao H, Gong C, Chen J, Su F, Zhang Y, Song E. Reduced miR-128 in breast tumor–initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clinical Cancer Research 2011; 17(22), 7105-15.
  11. Gong C, Bauvy C, Tonelli G, Yue W, Delome′nie C, Nicolas V, Zhu Y, Domergue V, Marin-Esteban V, Tharinger H, Delbos L, Gary-Gouy H, Morel A-P, Ghavami S, Song E, Codogno P and Mehrpour M. Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene. 2012
  12. Gong C, Song E, Codogno P, Mehrpour M.The roles of BECN1 and autophagy in cancer are context dependent. Autophagy. 2012; 8(12):1853-5.
  13. Nie Y, Liu X, Qu S, Song E, Zou H, Gong C. Long noncoding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Science. 2013.
  14. Gong C,Qu S, Liu B,Pan S,Jiao Y,Nie Y, Su F,Liu Q,Song E.  MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells. Oncogene 2013 Dec 2.
  15. Luo M, Gong C, Chen C, Lee D, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou X, Song E, Lu KP. Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer. Cancer Research 2014 May 1.
  16. Li H, Chen K, Su F, Song E, Gong C. Preoperative CA 15-3 levels predict the prognosis of nonmetastatic luminal A breast cancer. Journal of Surgical Research. 2014; 189(1):48-56.
  17. Gong C, Nie Y, Qu S, Liao J, Cui X, Yao H, Zeng Y, Su F, Song E, Liu Q. miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors. Cancer Research. 2014. pii: canres.0125.2014.
  18. Gong C, Qu S, Lv X, Liu B, Tan W, Nie Y, Su F, Liu Q, YaoH, Song E. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. Nature Communications. 2014; 5:5406.
  19. Liu B, Sun L, Liu Q, Gong C, Yao Y, Lv X, Lin L, Yao H, Su F, Li D, Zeng M, Song E. A Cytoplasmic NFκB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis. Cancer Cell. 2015 Mar 9; 27(3):370-81.
  20. Gong C, Liu B, Yao Y, Qu S, Luo W, Tan W, Liu Q, Yao H, Zou L, Su F, Song E. DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy. J Biol Chem. 2015 Jun 12; 290(24):14811-25.
  21. Chu J, Zhu Y, Liu Y, Sun L, Lv X, Wu Y, Hu P, Su F, Gong C, Song E, Liu B, Liu Q. E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter. Oncotarget. 2015 Oct 13; 6(31):31944-57.
  22. Hu P, Chu J, Wu Y, Sun L, Lv X, Zhu Y, Li J, Guo Q, Gong C, Liu B, Su S.NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2. Oncotarget. 2015 Oct 20; 6(32):32410-25.
  23. Tan W, Li Q, Chen K, Su F, Song E, Gong C. Estrogen receptor beta as a prognostic factor in breast cancer patients: A systematic review and meta-analysis. Oncotarget. 2016 Mar 1; 7(9):10373-85.
  24. Chen Y, Chen K, Xiao X, Nie Y, Qu S, Gong C, Su F, Song E.Pretreatment neutrophil-to-lymphocyte ratio is correlated with response to neoadjuvant chemotherapy as an independent prognostic indicator in breast cancer patients: a retrospective study. BMC Cancer. 2016 May 19; 16:320.
  25. Tan W, Gong C.  MicroRNAs and Cancer: key paradigms in molecular therapy. Oncology Letters. (Accepted)
  26. Gong C, Tan W, Chen K, You N, Zhu S, Liang G, Xie X, Li Q, Zeng Y, Ouyang N, Li Z, Zeng M, Zhuang S, Lau WY, Liu Q, Yin D, Wang X, Su F, Song E. Prognostic Value of a BCSC-associated MicroRNA Signature in Hormone Receptor-Positive HER2-Negative Breast Cancer. EBioMedicine. 2016 Sep; 11:199-209.
  27. TanW, LuoW, Jia W, Liang G, Xie X, Zheng W, Song E, Su F, Gong C. A combination of Nottingham prognostic index and IHC4 score predicts pathological complete response of neoadjuvant chemotherapy in estrogen receptor positive breast cancer. Oncotarget. 2016 Nov 24.
  28. Alexander PB, Chen R, Gong C, Yuan L, Jasper JS, Ding Y, Markowitz GJ, Yang P, Xu X, McDonnell DP, Song E, Wang XF. Distinct receptor tyrosine kinase subsets mediate anti-HER2 drug resistance in breast cancer. JBC 2016 Nov 30. pii: jbc.M116.754960.
  29. Liu Z, Jiang L, Liang G, Erwei Song, Zheng Y, Gong C. Hepatitis B Virus Reactivation in Breast Cancer Patients Undergoing Chemotherapy: a review and meta-analysis of . Journal of Viral Hepatitis 2016. (Accepted)

Journal of Breast Cancer Research and Advancements