Education

Biography

Michael Green, Ph.D., is a new faculty member at UNMC. Here's a brief rundown of his background and the expertise he brings to campus. Michael Green, Ph.D., is a new faculty member at UNMC. Here's a brief rundown of his background and the expertise he brings to campus.

Research Interest

The focus of the Green laboratory is to unravel the genetic underpinnings of lymphoid malignancies, with the ultimate goal of identifying and therapeutically targeting the molecular drivers of these cancers.

Professional Activities:

Honors and Awards

Publications

1. Hartert K, Liu C, Gentles A, Hartmann E, Mansouri L, Rosenquist R, Rosenwald A, Iqbal J, Levy R, Alizadeh A, Green M§. The landscape of somatic DNA copy number alterations in B-cell malignancies. Genome Res. 2015 (Under Review; §Corresponding Author)
2. Green M§, Kihira S, Moore D, Levy R, Alizadeh A. Chromatin modifying gene mutations in follicular lymphoma affect signatures of normal germinal center B-cell differentiation. Leukemia 2015 (Under Review; §Corresponding Author)
3. Keane C, Vari F, Hertzberg M, Le-Cao K, Green M, Han E, Seymour J, Hicks R, Gill D, Crooks P, Gould C, Jones K, Radford K, Griffiths L, Talaulikar D, Jain S, Tobin J, Gandhi M. Ratios of immune- effectors to immune-checkpoints measure net anti-tumoural immunity, and add to the predictive power of conventional prognosticators in diffuse large B cell lymphoma. Lancet Haem. 2015 (In Press)
4. Kurtz D*, Green M*, Bratman S, Liu C, Takahashi K, Glover C, Keane C, Kihira S, Visser B, Faham M, Corbelli K, Miklos D, Advani R, Levy R, Hertzberg M, Gandhi M, Diehn M, Alizadeh A. Non- invasive disease monitoring of diffuse large B-cell lymphoma throughout the course of disease by immunoglobulin deep sequencing. Blood 2015;125:3679-3687 (Plenary Paper, *Equally contributed, PMID: 25887775)
5. Green M§, Kihira S, Liu C, Nair R, Salari R, Czerwinski D, Irish J, Stehr H, Vicente-Duenes C, Romero- Camerero I, Sanchez-Garcia I, Plevritis S, Arber D, Botzaglou S, Levy R, Alizadeh A. Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation. Proc. Natl. Acad. Sci. USA 2015;112:E1116-11125 (PMID: 25713363; §Corresponding Author)
6. Newman A*, Liu C*, Green M, Gentles A, Feng W, Hoang C, Diehn M, Alizadeh A. Robust enumeration of cell subsets from expression profiles of complex tissues. Nat. Methods 2014;12:453-457 (PMID: 25822800)
7. Green M*, Vicente-Duenas C*, Romero-Camarero I, Liu C, Dai B, Gonzalez-Herrero I, Alonso- Escudero E, Iqbal J, Chan W, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, Jimenez R, Martinez-Climent J, Criado F, Cenador M, Zhao S, Natkuma Y, Lossos I, Majeti R, Melnick A, Cobaleda C, Alizadeh A, Sanchez-Garcia I. Transient expression of the Bcl6 oncogene is sufficient to induce mature B-cell lymphoma. Nat. Commun. 2014;5:3904 (PMID: 24887457, *Equally contributed)
8. Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell R, Zhuo G, Rajapaksa R, Green M, Torchia J, Brody J, Luong R, Rosenblum M, Levitsky H, Tse V, Levy R. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J. Clin. Ivest. 2013; 123: 2447-2463 (PMID: 23728179)
9. Green M, Gentles A, Nair R, Irish J, Kihira S, Kela I, Hopmans E, Myklebust J, Ji H, Plevritis S, Levy R, Alizadeh A. Hierarchy in somatic mutations arising during genomic evolution and progression of Follicular lymphoma. Blood 2013;121:1604-1611 (PMID: 23297126)
10. Aya-Bonilla C, Green M, Camilleri E, Benton M, Keane C, Marlton P, Lea R, Gandhi M, Griffiths L. High resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to non-Hodgkin’s lymphoma. Genes Chrom. Cancer 2013; 52: 467-479 (PMID: 23341091)
11. Myklebust J, Irish J, Brody J, Czerwinski D, Houot R, Kohrt H, Timmerman J, Said J, Green M, Delabie J, Kolstad A, Alizadeh A, Levy R. High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood 2013;121:1367-1376 (PMID: 23297127)
12. Romero-Camarero I, Jiang X, Natkunam Y, Lu X, Vicente-Dueñas C, Gonzalez-Herrero I, Flores T, Garcia J, McNamara G, Kunder C, Zhao S, Segura V, Fontan L, Martínez-Climent J, García-Criado F, Theis J, Dogan A, Campos-Sánchez E, Green M, Alizadeh A, Cobaleda C, Sánchez-García I, Lossos I. HGAL – a germinal center protein, enhances BCR-mediated Syk activation, leading to lymphoid hyperplasia and amyloidosis. Nat. Comm. 2013;l4:1338 (PMID: 23299888)
13. Green M, Rodig S, Juszczynski P, Sinha P, Ouyang J, O’Donnell E, Neuberg D, Shipp M. Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and post-transplant lymphoproliferative disorders: implications for targeted therapy. Clin. Cancer Res. 2012;18:1611-1618 (PMID: 22271878)
14. Caro P, Kishan A, Norberg E, Stanley I, Chapuy B, Ficarro S, Polak K, Tondera D, Gounarides J, Ying H, Zhou F, Green M, Chen L, Monti S, Marto J, Shipp M, Daniel N. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B-cell lymphoma. Cancer Cell 2012;22:547-560 (PMID: 23079663)
15. Green M, Camilleri E, Gandhi M, Peake J, Griffiths L. A novel immunodeficiency disorder characterised by genetic amplification of interleukin 25. Genes Immun. 2011;12:663-666 (PMID: 21776014)
16. Green M, Monti S, Dalla-Favera R, Pasqualucci L, Walsh N, Schmidt-Supprian M, Kutok J, Rodig S, Neuberg D, Rajewsky K, Golub T, Alt F Shipp M, Manis J. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc. Natl. Acad. Sci. USA 2011;108:2873-2878 (PMID: 21282644) [Faculty of 1000 recommended article]
17. Green M, Aya-Bonilla C, Gandhi M, Lea R, Wellwood J, Wood P, Marlton P, Griffiths L. Integrative genomic profiling reveals conserved mechanisms of tumorigenesis in common entities of non-Hodgkin’s lymphoma. Genes Chrom. Cancer 2011;50:313-326 (PMID: 21305641)
18. Nguyen-Van D, Keane C, Han E, Jones K, Nourse J, Vari F, Ross N, Crooks P, Ramuz O, Green M, Griffith L, Trappe R, Grigg A, Mollee P, Gandhi M. Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly expresses EBNA3A with conserved CD8+ T-cell epitopes. Am. J. Blood Res. 2011;1: 146-159 (PMID: 22432076)
19. 19. Kondratiev S, Duraisamy S, Unitt C, Green M, Pinkus G, Shipp M, Kutok J, Drapkin R, Rodig S. Aberrant expression of the dendritic cell marker TNFAIP2 in Hodgkin lymphoma and mediastinal large B cell lymphoma distinguishes these tumor types from morphologically and immunophenotypically similar lymphomas. Am. J. Surg. Pathol. 2011;35:1531-1539 (PMID: 21921781)
20. Ouyang J, Juszczynski P*, Rodig S*, Green M*, O’Donnell E, Currie T, Armant M, Takeyama K, Monti S, Rabinovich G, Ritz J, Kutok J, Shipp M. Viral induction and targeted inhibition of galectin-1 in EBV+ lymphoproliferative disorders. Blood 2011;117:4315-4322 (*Equally contributed, PMID: 21300977)
21. Green M, Monti S, Rodig S, Juszczynski P, Currie T, O’Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub T, Kutok J, Shipp M. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 2010;116:3268-3277 (PMID: 20628145)
22. Green M, Jardine P, Wood P, Wellwood J, Lea R, Marlton P, Griffiths L. A new method to detect loss of heterozygosity using cohort heterozygosity comparison. BMC Cancer 2010;10:195 (PMID: 20462409)
23. Green M, Gandhi M, Courtney M, Marlton P, Griffiths L. Relative abundance of full-length and truncated FOXP1 isoforms are associated with differential NFκB activity in Follicular lymphoma. Leuk. Res. 2009;33:1699-1702. (PMID: 19487025)
24. Green M, Gandhi M, Camilleri E, Marlton P, Lea R, Griffiths L. High levels of BACH2 are associated with low levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin’s lymphoma. Leuk. Res. 2009;33:731-734. (PMID: 18929412)