Education

Biography

Research Interest

Clinical malignant hematology: new therapies for lympho proliferative disorders (lymphoma, myeloma, CLL) and myelo proliferative neoplasms (MDS, PV, ET, myelofibrosis).

Professional Activities:

Publications

1. Grigorjev D, Kotchetkov R, Soldatenko P, Gerasimovitch A, Cherstvoy E: “Microscopic Investigation of the Retina by MSB-method”. Health Care in Belarus, 1994; 3: 53-56
2. Kotchetkov R, Gröschel B, Cinatl J, Rabenau H, Doerr H-W, Kornhuber B, Cinatl J jr: Zidovudine induces resistance to antineoplastic agents and alterations in apoptosis in T-cell lymphoma cells”. Haematology and Blood Transfusion 1997; 39: 469-474
3. Gröschel B, Cinatl J, Kotchetkov R, Köhl U, Rohrbach E, Kornhuber B, Bazzanini R, Perigaud C, Gosselin G, Imbach J.-L, Doerr H-W, Cinatl J jr: “Cytotoxic Activity and Pharmacology of an ARA-CMP Prodrug in T-leukemic Sublines Resistant to ARA-C”. Haematology and Blood Transfusion 1997; 39: 628-632
4. Kotchetkov R: “Different Effects of Anticancer Drugs on Undifferentiated 8505C Thyroid Cancer Cell Line”. Journal of BelarussianAcademy of Science 1997; 3:18-22
5. Cinatl J jr, Cinatl J, Hernaiz-Driever P, Kotchetkov R, Pouckova P, Kornhuber B, Schwabe D: “Sodium Valproate Inhibits In Vivo Growth of Human Neuroblastoma Cells”. Anti-Cancer Drugs 1997; 8: 958-963 
6. Kotchetkov R, Krivchik AA: “Chemotherapy for Undifferentiated Thyroid Cancer, Review of the Literature”. Medical News, 1997, 1: 3-9
7. Kotchetkov R, Krivchik AA: “Use of Anticancer Agents in Treatment of Differentiated Thyroid Cancer”, Health Care in Belarus, 1998; 5: 24-30
8. Cinatl J Jr, Cinatl J, Vogel J-U, Kotchetkov R, Hernaiz-Driever P, Kabickova H, Kornhuber B, Schwabe D, Doerr H-W: “Persistent Human Cytomegalovirus Infection Induces Drug Resistance and Alteration of Programmed Cell Death in Human Neuroblastoma Cells”.Cancer Res 1998, 15: 367-372
9. Cinatl J Jr, Kotchetkov R, Groschel B, Cinatl J, Hernaiz-Driever P, Kabickova H, Kornhuber B, Schwabe D, Doerr H-W: “Azidothymidine Resistance of H9 Human T-cell Lymphoma Cells is Associated With Decreased Sensitivity to Antitumor Agents and Inhibition of Apoptosis”.Int J Mol Med 1998, 2: 685-691
10. Koehl U, Gunkel M, Esser R, Kotchetkov R, Tonn T, Schwabe D, Kornhuber B: “Positive Selection of CD34+ peripheral hematopoietic blood stem cells”. Haematology and Blood Transfusion 1999; 43: 1278-1282
11. Koehl U, Esser R, Gunkel M, Gruettner H-P, Soerensen J, Kotchetkov R, Rohrbach E, Martin H, Bialleck H, Tonn T, Groeschel B, Vogel J-U, Cinatl J jr, Seifried E, Kornhuber B, Schwabe D: “Purification of CD34+ or AC133+ progenitor cells and CD56+ natural killer cells for autologous and allogeineic transplantation: modified purging strategy with enhanced purity and high depletion of T-cells”. Klinische Paediatrie 1999; 211: 371-374
12. Koehl U, Gunkel M, Gruettner H-P, Soerensen J, Esser R, Kotchetkov R, Keyser M, Tonn T, Schumm M, Handgratinger R, Groeschel B, Vogel J-U, Cinatl J jr, Niegemann E, Ebener U, Seifried E, Kornhuber B, Schwabe D: “Positive Selection of hematopoietic progenitor cells for autologous and allogeineic transplantation in pediatric patients with solid tumors and leukemia”. Transplantation in Haematology and Oncology 1999; 43: 1278-1282
13. Cinatl J Jr, Kotchetkov R, Scholz M, Cinatl J, Vogel J-U, Hernaiz-Driever P, Doerr H-W: “Human Cytomegalovirus Infection Decreases Expression of Thrombospondin-1 Independent of the Tumor Suppressor Protein p53”. Am J Pathol 1999, 155: 285-292
14. Kotchetkov R, Krivtchik AA, Cinatl J, Kornhuber B, Cinatl J Jr: “Selective Cytotoxic Activity of a Novel Ribonucleoside Diphosphate Reductase Inhibitor MDL-101,731 to Thyroid Cancer in Vitro”. Folia Biologica (Praga) 1999, 45: 185-191
15. Kotchetkov R, Krivtchik AA: “Sensitivity of Human Thyroid Cancer Cell Lines to Anticancer Drugs”. Health 1999; 5: 12-15
16. Cinatl J Jr, Cinatl J, Kotchetkov R, Hernaiz-Driever P, Bertels S, Siems K, Jas G, Bindseil K, Rabenau HF, Pouckova P, Doerr HW, Schwabe D: “Aphidicolin Glycinate Inhibits Human Neuroblastoma Cell Growth In Vivo”. Oncol Rep 1999; 6: 563-568
17. Cinatl J Jr, Cinatl J, Kotchetkov R, Vogel J-U, Woodcock BG, Matousek J, Pouckova P, Kornhuber B: “Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis”. Int J Oncol 1999; 15: 1001-1009
18. Cinatl J Jr, Cinatl J, Kotchetkov R, Vogel J-U, Kabickova H, Kornhuber B, Schwabe D: “Cytotoxicity of L-Cycloserin against Human Neuroblastoma and Medulloblastoma Cells is Associated with the Suppression of Ganglioside Expression”. Anticancer Res 1999; 19: 5349-5354
19. Cinatl J jr, Vogel J-U, Kotchetkov R, Scholz M, Doerr H-W: Proinflammatory Potential of Cytomegalovirus Infection”. Intervirology 1999; 42:419-424
20. Cinatl J jr, Kotchetkov R, Cinatl J, Weimer E, Blaheta R, Scholz M, Vogel J-U, Guembel HO, Doerr H-W: “The Antisense Oligonucleotide ISIS 2292 Prevents Cytomegalovirus-Induced Up-Regulation of IL-8 and ICAM-1 in Cultured Human Fibroblasts”. J Med Virol 2000; 60: 313-323
21. Gunkel M, Koehl U, Bartling T, Gruettner HP, Soerensen J, Esser R, Kotchetkov R, Martin H, Groeschel B, Vogel J-U, Cinatl J jr, Seifried E, Kornhuber B, Schwabe D: Purification of CD34+ or AC133+ Progenitor cells for autologous and allogenic transplantation: modified strategy with enhanced purity and hugh depletion of normal from malignant and T-cells. Bone Marrow Transplantation, 2000; Vol.25, Suppl. 1 S261
22. Koehl U, Bartling T, Esser R, Gunkel M, Buehler I, Gruettner H-P, Soerensen J, Kotchetkov R, Martin H, Seifried E, Kornhuber B, Schwabe D: Large-scale isolation of natural killer cells from haploidentical donors for posttransplant immunotherapy. Bone Marrow Transplantation, 2000; Vol.25, Suppl. 1 S123
23. Kotchetkov R, Cinatl J, Matousek J, Vogel J-U, Schwabe D, Cinatl J jr: “Bovine Seminal Ribonuclease Inhibits In Vivo Growth of Human Neuroblastoma Cells” Oncol Rep 2000; 7: 363-367
24. Kotchetkov R, Groeschel B, Krivtchik AA, Bitoova M, Cinatl J, Kornhuber B, Cinatl J jr: “Antineoplastic Activity of Gemcitabine-Monophosphate Against Thyroid Cancer Cells In Vitro” Anticancer Res 2000; 20: 2915-2922
25. Pasyukov VV, Kotchetkov R, Merkulova IP, Glushen SV, Melnikov IA: “Impact of MDL-101,731 on DNA content and structure of human anaplastic thyroid carcinoma” Biol Activ Metab Homeost 2000; 2: 110-112
26. Kotchetkov R, Krivtchik AA, Cinatl J, Vogel J-U, Michaelis M, Kornhuber B, Cinatl J, jr: “Cytotoxic Activity of BS-RNase Against Anaplastic Thyroid Cancer Cells In Vitro” Anticancer Res, 2001; 21: 1035-1042
27. Margraf S, Bittoova M, Vogel JU, Kotchetkov R, Doerr H-W, Cinatl J jr: “Antisense oligonucleotide ISIS 2922 targets IE-expression and prevents HCMV-IE-induced suppression of TSP-1 and TSP-2 expression”. Nucleosides Nucleotides Nucleic Acids 2001; 20: 1425-1428
28. Cinatl J jr, Kotchetkov R, Blaheta R, Hernaiz-Driever P, Vogel J-U, Cinatl J: “Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: Enhancement by combination with interferon-alpha”.  Int J Oncol 2002; 20: 97-106
29. Ciarallo S, Hung W, Subramaniam V, Lee J-H, Kotchetkov R, Sandhu C, Milic A, Slingerland J: “Altered p27Kip1 phosphorylation, localization and function in human epithelial cells resistant to Transforming Growth Factor-β mediated G1 arrest”. Mol Cell Biol 2002; 22: 1993-3002
30. Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor M, Han K, Lee J-H, Ciarallo S, Catzavedos C, Beniston R, Franssen E, Slingerland J: “PKB phosphorylates p27, impairs its nuclear import and opposes p27-mediated G1 arrest”. Nature Medicine 2002; 8: 1153-1160
31. Connor M, Kotchetkov R, Cariou S, Resh A, Lupetti R, Beniston R, Mechior F, Hengst L, Slingerland J. “CRM1/Ran-mediated nuclear export of p27Kip1 involves a nuclear export signal and links p27 export and proteolysis”. Mol Biol Cell, 2003, 14: 201-213
32. Kotchetkov R, Cinatl J, Vogel J-U, Schwabe D, Cinatl J jr: “Development of resistanceto vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model”. Int J Cancer. 2003; 104: 36-43.
33. Kotchetkov R, Krivchik AA, Tsybulko NP, Vismont FI, Cinatl J: “Sensitivity of thyroid cancer cell lines of different degree of differentiation to anticancer drugs”. News of Biomed Sci. 2002, 3: 78-85
34. Cinatl J jr, Cinatl J, Michaelis M, Kabickova H, Kotchetkov R, Vogel J-U, Doerr H-W, Klingebiel T, Hernaiz-Driever P: “Potent oncolytic activity of multimutated herpes simplex virus G207 in combination with vincristine against human rhabdomyosarcoma.” Cancer Res. 2003; 63: 1508-1514
35. Scholz M, Vogel J-U, Hover G, Prosch S, Kotchetkov R, Cinatl J, Koch F, Doerr H-W, Cinatl J jr: “Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells”. Med Microbiol Immunol (Berl). 2003; 193: 195-203
36.  Scholz M, Vogel J-U, Hover G, Kotchetkov R, Cinatl J, Doerr H-W, Cinatl J jr: “Thrombin stimulates IL-6 and IL-8 expression in cytomegalovirus-infected human retinal pigment epithelial cells”. Int J Mol Med. 2004; 13: 327-331
37. Cinatl J, Scholz M, Kotchetkov R, Vogel J-U, Doerr H-W: “Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology”. Trends Mol Med. 2004; 10: 19-23
38. Michaelis M, Michaelis UR, Fleming I, Suhan T, Cinatl J, Blaheta RA, Hoffmann K, Kotchetkov R, Busse R, Nau H, Cinatl J jr: “Valproic Acid inhibits angiogenesis in vitro and in vivo”. Mol Pharmacol. 2004; 65:520-527
39. Cinatl J Jr, Vogel J-U, Kotchetkov R, Doerr H-W: “Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression”. FEMS Microbiol Rev. 2004; 28: 59-77
40. Michaelis M, Kotchetkov R, Vogel JU, Doerr HW, Cinatl J jr: “Cytomegalovirus infection blocks apoptosis in cancer cells”. Cell Mol Life Sci. 2004; 61:1307-1316
41. Kotchetkov R, Hernaiz-Driever P, Michaelis M, Cinatl J, Blaheta RA, Karaskova, JA, Squire J, Cinatl J jr: “Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression”. Int J Oncol. 2005; 27: 1029-1038
42. Koehl U, Esser R, Zimmermann S, Sörensen J, Grüttner H-P, Martin H, Kotchetkov R, Bartling T, Lang P, Tonn T, Seidl C, Seifried E, Klingebiel T, Schwabe D: “Clinical scale selected and expanded CD56+ CD3- donor cells for immunotherapy”. Klinische Pediatrie 2005; 217: 345-50 
43. Michaelis M, Cinatl J, Anand P, Rothweiler F, Kotchetkov R, von Deimling A, Doerr H-W, Shogen K, Cinatl J jr. “Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells” Cancer Lett; 2007 18: 107-16.
44. Blaheta RA, Daher FH, Hasenberg C, Weich E, Jonas D, Kotchetkov R, Doerr H-W, Cinatl J jr. “Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulation of NCAM surface expression” BMC Cancer. 2006; 21: 294-7
45. Kotchetkov R, Booth J, Bolli P. Hypoglycemia as an initial presentation of diabetes mellitus Can J Gen Intern Med 2008; 3:180
46. Kotchetkov R, Millson R. Omeprazole Reduces Blood Level of Quetiapine. MUMJ, 2010;7:27-29
47. Kotchetkov R, Patel A, Salehian O. Ventricular Tachycardia in Pregnant Patients. Clinical Medicine Insights: Cardiology. 2010; 4: 39-44.
48. Kotchetkov R, Gupta V. Polycythemia Vera Followed by Hairy Cell Leukemia Variant. Blood: 120, 2012
49. Kotchetkov R, Ellison E. Metastatic Lobular Breast CarcinomaMimicking Multiple Myeloma. Blood: 124 (14),  2014
50. Kotchetkov R,  Kukreti V. Cavitating Mesenteric Lymph Node Syndrome and Enteropathy-Associated T Cell Lymphoma as First Manifestation of Celiac Disease (Canadian Journal of General Internal Medicine, 2015,in press)
51. Kotchetkov R, Masish-Khan E, Chu CM, Atenafu EG, Chen C, Kukreti V, Trudel S, Tiedemann R, Reece DE. Secondary Primary Malignancies during the Lenalidomide-Dexamethasone Regimen in Relapsed/Refractory Multiple Myeloma Patients (submitted)
52. Kotchetkov R, Price R. Microcellular variant of T-PLL mimicking CLL (manuscript in preparation)