Claudia Fazza
Claudia Fazza
Aggregate Professor
  • :+39 079 228592

Department of Biomedical Sciences
University of Sassari
Italy

Education

2004 Specialization in Haematology, Institute of Haematology, University of Sassari
1994 to 2000 Degree in Medicine, University of Sassari

 

Biography

  1. Aggregate Professor in Blood Diseases, Institute of Haematology, University of Sassari, since December 2011.
  2. Consultant in Haematology, Haematology Department, University of Sassari, since June 2007. -Researcher in Blood Diseases, Institute of Haematology, University of Sassari, since December 2006.
  3. Academic teaching at the University of Sassari, chair of Haematology since 2006.
  4. Since 2006 co-investigator and since 2012 principal investigator in several GIMEMA clinical trials. Experience in ICH-GCP.
  5. Principal investigator in several research projects funded by national and international authorities since 2006.
  6. Clinical fellow, Stem Cell Biology Section, Dept. of Immunology at Imperial College, Faculty of Medicine (Hammersmith Campus) in London from May 2005 to December 2006.
  7. Honorary Clinical Assistant and Clinical Trial Coordinator, Dept. of Haematolgy at Imperial College, Faculty of Medicine (Hammersmith Campus) in London from January 2005 to May 2006.

 

Research Interest

Blood Diseases

 

Professional Activities:

Scientific societies

  1. -Society of Hematologic Oncology
  2. -Italian Society of Haematology (SIE).
  3. -European Hematology Association (ESH).
  4. -Italian Society of Experimental Haematology (SIES).

 

Publications

  1. Fozza C, Corda G, Barraqueddu F, Virdis P, Contini S, Galleu A, Isoni A, Dore F, Angelucci E, Longinotti M. Azacitidine improves the T-cell repertoire in patients with myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. Leukemia research in press.
  2. Fozza C, Pardini S, Giannico DB, Targhetta C, Di Tucci AA, Dessalvi P, Angelucci E, Dore F. Dramatic erythroid response to low-dose Thalidomide in two patients with transfusion independent thalassemia and severe post-transfusional alloimmune haemolysis. Am J Hematol 2015;90:E141.
  3. Fianchi L, Pagano L, Piciocchi A, Candoni A, Gaidano G, Breccia M, Criscuolo M, Specchia G, Maria Pogliani E, Maurillo L, Aloe-Spiriti MA, Mecucci C, Niscola P, Rossetti E, Mansueto G, Rondoni M, Fozza C, Invernizzi R, Spadea A, Fenu S, Buda G, Gobbi M, Fabiani E, Sica S, Hohaus S, Leone G, Voso MT. Characteristics and outcome of therapy-related myeloid neoplasms: Report from the Italian network on secondary leukemias. Am J Hematol 2015;90:E80-5.
  4. Fozza C. The role of Cofarabine in the treatment of adults with Acute Myeoid Leukemia. Crit Rev Oncol Hematol in press.
  5. Fozza C, Corda G, Virdis P, Contini S, Barraqueddu F, Galleu A, Isoni A, Cossu A, Dore F, Careddu MG, Bonfigli S, Giannico B, Longinotti M. Derangement of the T-cell repertoire in patients with B-cell non-Hodgkin's lymphoma. Eur J Haematol 2014 Epub ahead of print.
  6. Fozza C, Dore F, Isoni MA, Longu F, Dessì L, Coppola L, Contini S, Longinotti M. Strabismus and diplopia in a patient with acute myeloid leukemia. Am J Case Rep 2014 3;15:288-90.
  7. Fozza C, Pardini S, Marras T, Longu F, Isoni A, Contini S, Longinotti M. Pseudothrombocytopenia in a patient receiving romiplostim for immune thrombocytopenic purpura. Ann Hematol 2014;93:899-900.
  8. Fozza C. Emerging immunological concepts in the pathogenesis of myelodysplastic syndromes. World J Hematol 2013; 2: 13-15.
  9. Fozza C. Remembering professor Maurizio Longinotti. Haematologica 2013; 98: 1988.
  10. Fozza C. Rituximab maintenance or retreatment after autologous transplantation for relapsed follicular lymphoma? J Clin Oncol 2013; 31: 3846-7.
  11. Fozza C, Pardini S, Coiana A, Rosatelli MC, Longinotti M. A novel pattern of uridine diphosphate glucuronosyltransferase polymorphisms associated with hyperbilirubinemia during nilotinib treatment. Blood Cell Mol Dis 2013; 51: 162.
  12. Farace F, Bulla A, Marongiu F, Campus GV, Tanda F, Lissia A, Cossu A, Fozza C, Rubino C. Anaplastic large cell lymphoma of the breast arising around mammary implant capsule: an italian report. Aesthetic Plast Surg 2013;37:567-71.
  13. Fozza C, Longinotti M. T-cell receptor repertoire usage in hematologic malignancies. Crit Rev Oncol Hematol 2012. Crit Rev Oncol Hematol 2013;86:201-11.
  14. Fozza C, Longinotti M. The role of T-cells in the pathogenesis of myelodysplastic syndromes: Passengers and drivers. Leuk Res 2013;37:201-3.
  15. Massa A, Fozza C.Large B-cell non-Hodgkin lymphoma relapsing with meningeal localization. Blood 2012; 119: 6185.
  16. Fozza C, Longu F, Contini S, Galleu A, Virdis P, Bonfigli S, Murineddu M, Gabbas A, Longinotti M. Patients with Early-Stage Myelodysplastic Syndromes Show Increased Frequency of CD4+CD25+CD127(low) Regulatory T Cells. Acta Haematol 2012; 128: 178-182.
  17. Galleu A, Fozza C, Simula MP, Contini S, Virdis P, Corda G, Pardini S, Cottoni F, Pruneddu S, Angeloni A, Ceccarelli S, Longinotti M. CD4(+) and CD8(+) T-Cell Skewness in Classic Kaposi Sarcoma. Neoplasia 2012; 14: 487-94.
  18. Fogu G, Campus PM, Cambosu F, Moro MA, Sanna R, Fozza C, Nieddu RM, Longinotti M, Montella A. Unbalanced 1q whole-arm translocation resulting in der(14)t(1;14)(q11-12;p11) in myelodysplastic syndrome. Cytogenet Genome Res 2012; 136: 256-63.
  19. Fozza C, Dazzi F. Regulatory T cells in stem cell transplantation: Main characters orwalk-on actors? Crit Rev Oncol Hematol 2012; 84: 18-25.
  20. Fozza C, Contini S, Corda G, Virdis P, Galleu A, Bonfigli S, Pacifico A, Maioli M, Mastinu F, Pitzalis M, Cucca F, Longinotti M. T-cell receptor repertoire analysis in monozygotic twins concordant and discordant for type 1 diabetes. Immunobiology 2012; 217: 920-5.
  21. Fozza C, Longinotti M. Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes? Eur J Haematol 2012; 88: 380-7.
  22. Amadori S, Stasi R, Martelli AM, Venditti A, Meloni G, Pane F, Martinelli G, Lunghi M, Pagano L, Cilloni D, Rossetti E, Di Raimondo F, Fozza C, Annino L, Chiarini F, Ricci F, Ammatuna E, La Sala E, Fazi P, Vignetti M. Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107). Br J Haematol 2012; 156: 205-12.
  23. Fozza C, Zoledzieska M, Pitzalis M, Simula MP, Galleu A, Contini S, Bonfigli S, Cucca F, Longinotti M. TCRBV20S1 polymorphism does not influence the susceptibility to type 1 diabetes and multiple sclerosis in the Sardinian population. Immunogenetics 2012; 64: 153-4.
  24. Fozza C, Contini S, Virdis P, Galleu A, Massa A, Bonfigli S, Longinotti M. Patients with myelodysplastic syndromes show reduced frequencies of CD4(+) CD8(+) double-positive T cells. Eur J Haematol 2012; 88: 89-90.
  25. Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; on behalf of the GIMEMA Acute Leukemia Working Party. Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2011; 118: 6521-6528.
  26. Fozza C, Poddie F, Contini S, Galleu A, Cottoni F, Longinotti M, Cucca F. Keratitis-Ichthyosis-Deafness Syndrome, Atypical Connexin GJB2 Gene Mutation, and Peripheral T-CellLymphoma: More Than a Random Association?. Case Reports in Hematology 2011, Article ID 848461, 3 pages, 2011.
  27. Fozza C, Longinotti M. Use of rituximab in autoimmune hemolytic anemia associated withnon-hodgkin lymphomas. Adv Hematol. 2011;2011:960137.
  28. Fozza C, Longinotti M. T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications. Adv Hematol. 2011;2011:501659.
  29. Chiaretti S, Messina M, Tavolaro S, Zardo G, Elia L, Vitale A, Fatica A, Gorello P, Piciocchi A, Scappucci G, Bozzoni I, Fozza C, Candoni A, Guarini A, Foà R. Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223. Haematologica 2010; 95: 1114-21.
  30. Fozza C, Galleu A, Careddu MG, Giannico DB, Bonfigli S, Contini S, Longinotti M. Efficacy of rituximab in autoimmune hemolytic anemia associated with splenic marginal zone lymphoma. Ann Hematol 2010; 89: 113-4.
  31. Fozza C, Contini S, Galleu A, Simula MP, Virdis P, Bonfigli S, Longinotti M. Patients with myelodysplastic syndromes display several T-cell expansions, which are mostly polyclonal in the CD4(+) subset and oligoclonal in the CD8(+) subset. Exp Hematol 2009; 37: 947-55.
  32. Cocco M, Pardini S, Podda L, Fozza C, Longinotti M. Prompt recovery of chemotherapy associated Hand-Foot syndrome treated with acetylsalicylic acid in two patients with Hodgkin's lymphoma. Eur J Haematol 2009; 82: 164.
  33. Pardini S, Fozza C, Contini S, Rimini E, Ottaviani E, Amabile M, Rosti G, Longinotti M. A case of coexistence between JAK2V617F and BCR /ABL. Eur J Haematol 2008; 81: 75-6.
  34. Podda L, Fozza C, Nieddu R, Sanna S, Paglietti B, Vacca A, La Nasa G, Longinotti M. Breakthrough cutaneous alternariosis in a patient with acute lymphoblastic leukemia: clinical features and diagnostic issues. Leuk Lymphoma 2008; 49:154-5.
  35. Dazzi F, Fozza C. Reply to “Splenectomy status of the patient may have impact on response to donor lymphocyte infusions” by Duygu U Çetinkaya et al. Leukemia 2007, 21: 2050- 51.
  36. Dazzi F, Fozza C. Disease relapse after transplantation: risk factors and treatment. Best Pract Res Hem 2007; 20: 311-27.
  37. Simula MP, Marktel S, Fozza C, Kaeda J, Szydlo RM, Nadal E, Bua M, Rahemtulla A, Kanfer E, Marinc D, Olavarria E, Goldman JM, Apperley JF and Dazzi F. Response to donor lymphocyte infusions for chronic myeloid leukemia is dose dependent: the importance of escalating the cell dose to maximize therapeutic efficacy. Leukemia 2007; 21: 943-8.
  38. Fozza C, Szydlo RM, Nadal E, Goldman JM, Apperley JF, Dazzi F. Factors for graft-versus-host disease after donor lymphocyte infusions with an escalating dose regimen: lack of association with cell dose. Br J Hematol 2007; 136: 833-6.
  39. Fozza C, Nadal E, Longinotti M, Dazzi F. T-cell receptor repertoire usage after allografting differs between CD4+CD25+ regulatory T-cells and their CD4+CD25- counterpart. Haematologica 2007; 92: 206-14.
  40. Bonfigli S, Fozza C, Contini S, Buzzetti R, Cucca F, Longinotti M. High frequency of the TCRBV20S1 “null allele“ in the Sardinian population. Human Immunology 2007; 68: 426-9.
  41. Vitale A, Guarini A, Ariola C, Mancini M, Mecucci C, Cuneo A, Pane F, Saglio G, Cimino G, Tafuri A, Meloni G, Fabbiano F, Recchia A, Kropp MG, Krampera M, Cascavilla N, Ferrara F, Romano A, Mazza P, Fozza C, Paoloni F, Vignetti M, Foa' R. Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol. Blood 2006; 107: 473-9.
  42. Fozza C, Bellizzi S, Piseddu G, Porcu A, Dore F, Longinotti M. Acquired hemophilia in a patient affected by acute myeloid leukemia. Am J Hematol 2005; 79: 81-2.
  43. Fozza C, Dore F, Bonfigli S, Podda L, Longinotti M. Two cases of chronic lymphoproliferative disorders in psoriatic patients treated with Cyclosporine: hairy cell leukemia and Waldenstrom macroglobulinemia. Eur J Dermatol 2005; 15: 271-3.
  44. Fozza C, Bellizzi S, Bonfigli S, Campus PM, Dore F, Longinotti M. Cytogenetic and hematological spontaneous remission in a case of acute myelogenous leukemia. Eur J Haematol 2004; 73: 219-22.
  45. Ricchi A, Carta A, Pinna G, Cirio E, Foddanu M, Terrosu PF, Pardini S, Fozza C, Longinotti M. Asymptomatic cardiac lymphoma in a HCV* thalassemic patient. Ital Heart J 2004; 5: 302-4.
  46. Fozza C, Bonfigli S, Conti M, Dore F, Longinotti M. Long-lasting fever of unknown origin preceding the diagnosis of intravascular lymphomatosis: a further case stimulates some remarks.  Am J Hematol 2003; 74: 211-3.
  47. Bonfigli S, Doro MG, Fozza C, Derudas D, Dore F, Longinotti M. T Cell receptor repertoire in healthy Sardinian subjects. Human Immunology 2003; 64: 689-95. I authorize the use of my personal data according to DSL 196/2003.

 

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