Christian Breymann
Christian Breymann
Senior Lecturer
  • :+41 43 818 58 68
  • :+41 43 818 59 61

Obstetric Research- Feto Maternal Haematology
University Hopsital of Zurich


1981-84                Human  medicine,  preclinical,  at  the  Universities  of  Chieti,  Italy   and Verona, Italy (preclinical)
1985-89 Clinical term undertaken at the Technische Universität München  (Munich University of Technology), Rechts der Isar Clinic (Hospital).
1989 State (Qualifying) Examination in Medicine in Munich.



Born in 1962 in Mannheim/ Germany, Medical school in Italy and Munich. Moved 1991 to Switzerland as a research stipendiate for DFG (Deutsche Forschungsgemeinschaft) at the University Hopsital Zurich, Dept. Obstetrics & Gynecology.
Specialized in OBGYN and Perinatal Medicine and Professor at the University of Zurich since 2001.
Co founder of GGS ( Gynäkologie Geburtshilfe Seefeld) center and founder of the swiss perinatal institute "Perinatal Zürich" which is linked to Zurich Hirslanden private clinics.
In addition to his clinical work he had a research post at the University of Zurich, Obstetric research and an active international guest lecture activity. He also had appointed guest professor at the Medical School of Adis Abeba University at the "Black Lion Hospital".

Research Interest

Feto Maternal Haematology, Obstetric research

Professional Activities:

3/2015 Scientific and Organization Board Member of the 2nd European Iron Academy Meeting in Paris / France
3/2015 Member NATA Expert Panel in the field of anemia therapy in pregnancy and postpartum, Paris/ France
2/2015 Selected as External Reviewer of updated WHO Guidelines for the Treatment of Postpartum Anemia
3/2014 Appointed Expert Board Member of Evalue-Science Switzerland in the Field of technical consequences of new prenatal genetic diagnostics
3/2014 Founding member of the International Stem Cell Society, Boston / USA
12/2013 Appointed Co- Chairman of the First European Iron Academy, Spain
2012 Appointed Board member of the HMB (Heavy menstrual bleeding) expert panel of Vifor International Inc. Switzerland
12/2011 Appointed honorary professor at the AAU-School of Medicine, Dept. Obetstrics and Gynecology, Adis Abeba/ Aethopia



  1. Breymann C. Iron Deficiency Anemia in Pregnancy. Semin Hematol. 2015Oct;52(4):339-47. doi:10.1053/j.seminhematol.2015.07.003. Epub 2015 Jul 10. Review. PubMed PMID: 26404445.
  2. Auerbach M, Adamson J, Bircher A, Breymann C, Fishbane S, Gafter-Gvili A, Gasche C, Gilreath J, Grazzini G, Henry D, Liumbruno G, Locatelli F, Macdougall I, Munoz M, Rampton D, Rodgers G, Shander A. On the safety of intravenous iron, evidence trumps conjecture. Haematologica. 2015 May;100(5):e214-5. doi: 10.3324/haematol.2014.121004. PubMed PMID: 25944640; PubMed Central PMCID: PMC4420237.
  3. Fraser IS, Mansour D, Breymann C, Hoffman C, Mezzacasa A, Petraglia F. Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey. Int J Gynaecol Obstet. 2015 Mar;128(3):196-200. doi: 10.1016/j.ijgo.2014.09.027. Epub 2014 Dec 1. PubMed PMID: 25627706.
  4. Bencaiova G, Breymann C. Mild anemia and pregnancy outcome in a Swiss collective. J Pregnancy. 2014;2014:307535. doi: 10.1155/2014/307535. Epub 2014 Nov 13. PubMed PMID: 25478229; PubMed Central PMCID: PMC4247945.
  5. Oneda B, Baldinger R, Reissmann R, Reshetnikova I, Krejci P, Masood R, Ochsenbein-Kölble N, Bartholdi D, Steindl K, Morotti D, Faranda M, Baumer A, Asadollahi R, Joset P, Niedrist D, Breymann C, Hebisch G, Hüsler M, Mueller R, Prentl E, Wisser J, Zimmermann R, Rauch A. High-resolution chromosomal microarrays in prenatal diagnosis significantly increase diagnostic power. Prenat Diagn. 2014 Jun;34(6):525-33. doi: 10.1002/pd.4342. Epub 2014 Mar 21. PubMed PMID: 24919595.
  6. Favrat B, Balck K, Breymann C, Hedenus M, Keller T, Mezzacasa A, Gasche C. Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women--PREFER a randomized, placebo-controlled study. PLoS One. 2014 Apr 21;9(4):e94217. doi: 10.1371/journal.pone.0094217. eCollection 2014. PubMed PMID: 24751822; PubMed Central PMCID: PMC3994001.
  7. Bencaiova G, Burkhardt T, Breymann C. Anemia--prevalence and risk factors in pregnancy. Eur J Intern Med. 2012 Sep;23(6):529-33. doi: 10.1016/j.ejim.2012.04.008. Epub 2012 May 4. PubMed PMID: 22863430.
  8. Jacob M, Annaheim S, Boutellier U, Hinske C, Rehm M, Breymann C, Krafft A. Haematocrit is invalid for estimating red ell volume: a prospective study in male volunteers. Blood Transfus. 2012 Oct;10(4):471-9. doi: 10.2450/2012.0111-11. Epub 2012 May 4. PubMed PMID: 22682340; PubMed Central PMCID: PMC3496233.
  9. Weber B, Schoenauer R, Papadopulos F, Modregger P, Peter S, Stampanoni M, Mauri A, Mazza E, Gorelik J, Agarkova , Frese L, Breymann C, Kretschmar O, Hoerstrup SP. Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices. Biomaterials. 2011 Dec;32(36):9630-41. doi: 10.1016/j.biomaterials.2011.07.070. Epub 2011 Oct 5. PubMed PMID: 21978890.
  10. Ortiz R, Toblli JE, Romero JD, Monterrosa B, Frer C, Macagno E, Breymann C. Efficacy and safety of oral iron(III) polymaltose complex versus ferrous sulfate in pregnant women with iron-deficiency anemia: a multicenter, randomized, controlled study. J Matern Fetal Neonatal Med. 2011 Nov;24(11):1347-52. doi: 10.3109/14767058.2011.599080. Epub 2011 Aug 23. PubMed PMID: 21859366.
  11. Krayenbuehl PA, Battegay E, Breymann C, Furrer J, Schulthess G. Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration. Blood. 2011 Sep 22;118(12):3222-7. doi: 10.1182/blood-2011-04-346304. Epub 2011 Jun 24. PubMed PMID: 21705493.
  12. Krafft A, Breymann C. Iron sucrose with and without recombinant erythropoietin for the treatment of severe postpartum anemia: a prospective, randomized, open-label study. J Obstet Gynaecol Res. 2011 Feb;37(2):119-24. doi: 10.1111/j.1447-0756.2010.01328.x. Epub 2010 Dec 16. PubMed PMID: 21159035.
  13. Breymann C, Bian XM, Blanco-Capito LR, Chong C, Mahmud G, Rehman R. Expert recommendations for the diagnosis and treatment of iron-deficiency anemia during pregnancy and the postpartum period in the Asia-Pacific region. J Perinat Med. 2011 Mar;39(2):113-21. doi: 10.1515/JPM.2010.132. Epub 2010 Nov 11. PubMed PMID: 21070128.
  14. Breymann C, Honegger C, Holzgreve W, Surbek D. Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum. Arch Gynecol Obstet. 2010 Nov;282(5):577-80. doi: 10.1007/s00404-010-1532-z. Epub 2010 Jun 25. Review. PubMed PMID: 20577752.
  15. Krafft A, Bencaiova G, Breymann C. Selective use of recombinant human erythropoietin in pregnant patients with severe anemia or nonresponsive to iron sucrose alone. Fetal Diagn Ther. 2009;25(2):239-45. doi: 10.1159/000223441. Epub 2009 Jun 5. PubMed PMID: 19506383.
  16. Bencaiova G, Breymann C. Acquired sideroblastic anaemia following progesterone treatment in pregnancy. Aust N Z J Obstet Gynaecol. 2009 Apr;49(2):235-6. doi: 10.1111/j.1479-828X.2009.00952.x. PubMed PMID: 19432620.
  17. Breymann C. [Anemia and thrombocytopenia: early detection of risks]. Dtsch Med Wochenschr. 2008 Mar;133(11):534. doi: 10.1055/s-2008-1046747. German. PubMed PMID: 18320489.
  18. Breymann C, Gliga F, Bejenariu C, Strizhova N. Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. Int J Gynaecol Obstet. 2008 Apr;101(1):67-73. doi: 10.1016/j.ijgo.2007.10.009. Epub 2008 Jan 29. PubMed PMID: 18234203.
  19. Muñoz M, Breymann C, García-Erce JA, Gómez-Ramírez S, Comin J, Bisbe E. Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion. Vox Sang. 2008 Apr;94(3):172-83. Epub 2007 Dec 7. Review. PubMed PMID: 18069918.
  20. Schmidt D, Achermann J, Odermatt B, Breymann C, Mol A, Genoni M, Zund G, Hoerstrup SP. Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source. Circulation. 2007 Sep 11;116(11 Suppl):I64-70. PubMed PMID: 17846327.
  21. Breymann C. Treatment of iron deficiency anaemia in pregnancy and postpartum with special focus on intravenous iron sucrose complex. J Med Assoc Thai. 2005 Oct;88 Suppl 2:S108-9. PubMed PMID: 17718296.
  22. Schmidt D, Mol A, Odermatt B, Neuenschwander S, Breymann C, Gössi M, Genoni M, Zund G, Hoerstrup SP. Engineering of biologically active living heart valve leaflets using human umbilical cord-derived progenitor cells. Tissue Eng. 2006
  23. Nov;12(11):3223-32. PubMed PMID: 17518636. 23: Breymann C, von Seefried B, Stahel M, Geisser P, Canclini C. Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex. J Perinat Med. 2007;35(2):115-8. PubMed PMID: 17302514.
  24. Breymann C, Schmidt D, Hoerstrup SP. Umbilical cord cells as a source of cardiovascular tissue engineering. Stem Cell Rev. 2006;2(2):87-92. Review. PubMed PMID: 17237546.
  25. Bencaiova G, Krafft A, Burkhardt T, Breymann C. Variable efficacy of recombinant human erythropoietin in anemic pregnant women with different forms of heterozygous hemoglobinopathy. Acta Haematol. 2006;116(4):259-65. PubMed PMID: 17119327.
  26. Schmidt D, Asmis LM, Odermatt B, Kelm J, Breymann C, Gössi M, Genoni M, Zund G, Hoerstrup SP. Engineered living blood vessels: functional endothelia generated from human umbilical cord-derived progenitors. Ann Thorac Surg. 2006 Oct;82(4):1465-71; discussion 1471. PubMed PMID: 16996955.
  27. Schmidt D, Mol A, Breymann C, Achermann J, Odermatt B, Gössi M, Neuenschwander S, Prêtre R, Genoni M, Zund G, Hoerstrup SP. Living autologous heart valves engineered from human prenatally harvested progenitors. Circulation. 2006 Jul 4;114(1 Suppl):I125-31. PubMed PMID: 16820561.
  28. Bencaiova G, Krafft A, Breymann Ch. Sickle cell trait and urinary tract infection in pregnancy. Int J Gynaecol Obstet. 2006 Feb;92(2):128-9. Epub 2005 Dec 15. PubMed PMID: 16343499.
  29. Schäffer L, Vogel J, Breymann C, Gassmann M, Marti HH. Preserved placental oxygenation and development during severe systemic hypoxia. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R844-51. Epub 2005 Sep 29. PubMed PMID: 16195499.
  30. Schmidt D, Mol A, Neuenschwander S, Breymann C, Gössi M, Zund G, Turina M, Hoerstrup SP. Living patches engineered from human umbilical cord derived fibroblasts and endothelial progenitor cells. Eur J Cardiothorac Surg. 2005 May;27(5):795-800. PubMed PMID: 15848316.
  31. Krafft A, Perewusnyk G, Hänseler E, Quack K, Huch R, Breymann C. Effect of postpartum iron supplementation on red cell and iron parameters in non-anaemic iron-deficient women: a randomised placebo-controlled study. BJOG. 2005 Apr;112(4):445-50. PubMed PMID: 15777442.
  32. Hartmann S, Krafft A, Huch R, Breymann C. Effect of altitude on thrombopoietin and the platelet count in healthy volunteers. Thromb Haemost. 2005 Jan;93(1):115-7. PubMed PMID: 15630500.
  33. Schmidt D, Breymann C, Weber A, Guenter CI, Neuenschwander S, Zund G, Turina M, Hoerstrup SP. Umbilical cord blood derived endothelial progenitor cells for tissue engineering of vascular grafts. Ann Thorac Surg. 2004 Dec;78(6):2094-8. PubMed PMID: 15561042.
  34. Krafft A, Breymann C. Haemoglobinopathy in pregnancy: diagnosis and treatment. Curr Med Chem. 2004 Nov;11(21):2903-9. Review. PubMed PMID: 15544482.
  35. Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA. Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pharmacogenetics. 2004 Feb;14(2):91-102. PubMed PMID: 15077010.
  36. Kadner A, Zund G, Maurus C, Breymann C, Yakarisik S, Kadner G, Turina M, Hoerstrup SP. Human umbilical cord cells for cardiovascular tissue engineering: a comparative study. Eur J Cardiothorac Surg. 2004 Apr;25(4):635-41. PubMed PMID: 15037283.
  37. Krafft A, Huch R, Hartmann S, Breymann C. Combined thrombopoietin and platelet response to altitude in a patient with autoimmune thrombocytopenia. Thromb Haemost. 2004 Mar;91(3):626-7. PubMed PMID: 15025089.
  38. Schäffer L, Scheid A, Spielmann P, Breymann C, Zimmermann R, Meuli M, Gassmann M, Marti HH, Wenger RH. Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation. Placenta. 2003 Nov;24(10):941-50. PubMed PMID: 14580376.
  39. Krafft A, Huch R, Breymann C. Impact of parturition on iron status in nonanaemic iron deficiency. Eur J Clin Invest. 2003 Oct;33(10):919-23. PubMed PMID: 14511365.
  40. Breymann C. Iron deficiency and anaemia in pregnancy: modern aspects of diagnosis and therapy. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):506-16; discussion 517-21. PubMed PMID: 12547241.
  41. Kashiwagi M, Breymann C, Huch R, Huch A. Hypertension in a pregnancy with renal anemia after recombinant human erythropoietin (rhEPO) therapy. Arch Gynecol Obstet. 2002 Nov;267(1):54-6. PubMed PMID: 12410378.
  42. Kadner A, Hoerstrup SP, Tracy J, Breymann C, Maurus CF, Melnitchouk S, Kadner G, Zund G, Turina M. Human umbilical cord cells: a new cell source for cardiovascular tissue engineering. Ann Thorac Surg. 2002 Oct;74(4):S1422-8. PubMed PMID: 12400830.
  43. Hoerstrup SP, Kadner A, Breymann C, Maurus CF, Guenter CI, Sodian R, Visjager JF, Zund G, Turina MI. Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells. Ann Thorac Surg. 2002 Jul;74(1):46-52; discussion 52. PubMed PMID: 12118802.
  44. Perewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years experience with iron-sucrose complex. Br J Nutr. 2002 Jul;88(1):3-10. Review. PubMed PMID: 12117422.
  45. Krafft A, Breymann C, Streich J, Huch R, Huch A. Hemoglobin concentration in multiple versus singleton pregnancies--retrospective evidence for physiology not pathology. Eur J Obstet Gynecol Reprod Biol. 2001 Dec 1;99(2):184-7. PubMed PMID: 11788168.
  46. Ochsenbein-Imhof N, Hebisch G, Stallmach T, Breymann C, Huch A. [Two-stage delivery after spontaneous rupture of fetal membranes and delayed abortion of the first twin in conservative management]. Z Geburtshilfe Neonatol. 2001 Jul-Aug;205(4):152-5. German. PubMed PMID: 11570196.
  47. Breymann C; Anaemia Working Group. [Current aspects of diagnosis and therapy of iron deficiency anemia in pregnancy]. Praxis (Bern 1994). 2001 Aug 2;90(31-32):1283-91. Review. German. PubMed PMID: 11519193.
  48. Breymann C, Visca E, Huch R, Huch A. Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency anemia during pregnancy. Am J Obstet Gynecol. 2001 Mar;184(4):662-7. PubMed PMID: 11262469.
  49. Rohling RG, Zimmermann AP, Breymann C. Intravenous versus oral iron supplementation for preoperative stimulation of hemoglobin synthesis using recombinant human erythropoietin. J Hematother Stem Cell Res. 2000 Aug;9(4):497-500. PubMed PMID: 10982248.
  50. Krafft A, Breymann C, Huch R, Huch A. Intravenous iron sucrose in two pregnant women with inflammatory bowel disease and severe iron deficiency anemia Acta Obstet Gynecol Scand. 2000 Aug;79(8):720-2. PubMed PMID: 10949245.
  51. Breymann C. Erythropoietin test methods. Baillieres Best Pract Res Clin Endocrinol Metab. 2000 Mar;14(1):135-45. Review. PubMed PMID: 10932816.
  52. Breymann C, Rohling R, Huch A, Huch R. Intraoperative endogenous erythropoietin levels and changes in intravascular blood volume in healthy humans. Ann Hematol. 2000 Apr;79(4):183-6. PubMed PMID: 10834505.
  53. Breymann C, Rohling R, Krafft A, Huch A, Huch R. 'Blood doping' with recombinant erythropoietin (rhEPO) and assessment of functional iron deficiency in healthy volunteers. Br J Haematol. 2000 Mar;108(4):883-4. PubMed PMID: 10792301.
  54. Breymann C, Richter C, Hüttner C, Huch R, Huch A. Effectiveness of recombinant erythropoietin and iron sucrose vs. iron therapy only, in patients with postpartum anaemia and blunted erythropoiesis. Eur J Clin Invest. 2000 Feb;30(2):154-61. PubMed PMID: 10651841.
  55. Heinonen S, Breymann C, Ryynänen M, Gautschi K, Huch R, Huch A, Kirkinen P. Unexplained elevated serum hCG is associated with raised amniotic fluid erythropoietin levels in second-trimester pregnancies. Fetal Diagn Ther. 1999 Sep-Oct;14(5):286-90. PubMed PMID: 10529572.
  56. Krafft A, Breymann C, Hüttner C, Huch R, Huch A. Erythropoietic quality of maternal milk. Lancet. 1999 Aug 28;354(9180):778. PubMed PMID: 10475225.
  57. Breymann C, Perewusnyk G, Guntermann H, Hänseler E, Huch R. Unrecognised iron deficiency in critical illness. Lancet. 1999 Mar 6;353(9155):841-2. PubMed PMID: 10459984.
  58. Breymann C, Fibach E, Visca E, Huettner C, Huch A, Huch R. Induction of fetal hemoglobin synthesis with recombinant human erythropoietin in anemic patients with heterozygous beta-thalassemia during pregnancy. J Matern Fetal Med. 1999 Jan-Feb;8(1):1-7. PubMed PMID: 10052837.
  59. Hüttner C, Breymann C, Huch R, Huch A. [Effect of continuous intravenous tocolysis with beta 2-mimetics and magnesium sulfate on erythropoietin level]. Z Geburtshilfe Neonatol. 1998 Sep;202(5):192-6. German. PubMed PMID: 9857444.
  60. Hoigné R, Breymann C, Künzi UP, Brunner F. [Parenteral iron therapy: problems and possible solutions]. Schweiz Med Wochenschr. 1998 Apr 4;128(14):528-35. German. PubMed PMID: 9592894.
  61. Breymann C, Zimmermann R, Huch R, Huch A. Use of recombinant human erythropoietin in combination with parenteral iron in the treatment of postpartum anaemia. Eur J Clin Invest. 1996 Feb;26(2):123-30. PubMed PMID: 8904521.
  62. Breymann C, Bauer C, Major A, Zimmermann R, Gautschi K, Huch A, Huch R. Optimal timing of repeated rh-erythropoietin administration improves its effectiveness in stimulating erythropoiesis in healthy volunteers. Br J Haematol.1996 Feb;92(2):295-301. PubMed PMID: 8602988.
  63. Breymann C, Major A, Richter C, Huch R, Huch A. Recombinant human erythropoietin and parenteral iron in the treatment of pregnancy anemia: a pilot study. J Perinat Med. 1995;23(1-2):89-98. PubMed PMID: 7658327.
  64. Zimmermann R, Breymann C, Richter C, Huch R, Huch A. rhEPO treatment of postpartum anemia. J Perinat Med. 1995;23(1-2):111-7. PubMed PMID: 7658310.
  65. Major A, Bauer C, Breymann C, Huch A, Huch R. rh-erythropoietin stimulates immature reticulocyte release in man. Br J Haematol. 1994 Jul;87(3):605-8. PubMed PMID: 7993803
  66. Zimmermann R, Breymann C, Huch R, Huch A. rHuEPO in the treatment of postpartum anemia: subcutaneous versus intravenous administration. Clin Investig. 1994;72(6 Suppl):S25-30. PubMed PMID: 7950168.

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