Lanchun Lu
Sophie Laurent
Associate Professor

General, Organic and Biomedical Chemistry Laboratory
University of Mons (UMONS),
Belgium

Education

1989-1993 PhD student (promotors: Y. Van Haverbeke, University of Mons-Hainaut).
1993 Ph D thesis in sciences (chemistry) - University of Mons-Hainaut
1993-2003 assistant at the Medicine Faculty of the University of Mons-Haianut
2003-2007

postdoctoral researcher at the Medicine Faculty of the University of Mons-Hainaut

2007-2011

first assistant at the Medicine Faculty of the University of Mons

 

Biography

Sophie Laurent was born in 1967. Her studies were performed at the University of Mons-Hainaut (Belgium) where she received her PhD in Chemistry in 1993. She joined then Prof R.N. Muller’s team and was involved in the development (synthesis and physicochemical characterization) of paramagnetic Gd complexes and superparamagnetic iron oxide nanoparticles as contrast agents for MRI. She is currently working on the vectorization of contrast agents for molecular imaging. She is associate professor and co-author around 220 publications and more than 300 communications in international meetings.


Research Interest

  1. Studies of interaction between contrast agents and biological receptors (by mass spectrometry, NMR, relaxometry, ultrafiltration, …)
  2. Multimodal imaging studies in collaboration with the Center for Microscopy and Molecular Imaging of Gosselies (CMMI)

 

Professional Activities:

AWARDS:

  1. Price « BelgoChlor » for the best poster communication : “Ciblage de la phosphatidylsérine par phage display: synthèse d’un agent de contraste IRM spécifique de l’apoptose”, C. Laumonier, J. Segers, S. Laurent, C. Burtea, A. Michel, L. Vander Elst, R.N. Muller, SRC, Mons, Belgium (2003)
  2. Price of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) ("magna cum laude"): “Molecular imaging of angiogenic blood vessels in vulnerable atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA", C. Burtea, S. Laurent, L. Vander Elst, G. Toubeau et R.N. Muller, 23th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Warsow, Poland (2006)
  3. Price for the best poster “Synthesis and characterization of new versatile Lanthanide MRI contrast agents”, S.N.M. Chilla, S. Laurent, L. Vander Elst, R.N. Muller, 8th International conference on f-Block elements, Udine, Italy (2012)
  4. Price for the best poster “G. Rigaux, V.G. Roullin, C. Cadiou, G. Boeuf, M-C. Andry, B Bercu, M. Molinari, C. Portefaix, C. Hoeffel, S. Laurent, L. Vander Elst, R.N. Muller, F. Chuburu, « PLGA nanoparticles incorporating lipophilic Gd contrast agents », GTRV, Orléans, France (2013)
  5. Price for the best poster S.N.M. Chilla, S. Laurent, J. Kotek, O. Zemek, P. Hermann, L. Vander Elst, I. Lukes, R.N. Muller, « Synthesis and characterization of a new gadolinium (III) complex of monophosphinic acid analogue of DOTA as potential targeted and multimodal contrast agent”, RITC, Interfacing Chemical Biology and Drug Discovery, 50èmes Rencontres Internationales de Chimie Thérapeutique, Rouen, France (02-04 juillet 2014).

 

Publications

Articles in international journals with peer journal

  1. D. Forge, S. Laurent, Y. Gossuin, A. Roch, L. Vander Elst and R.N. Muller, “An original route to stabilize and functionalize magnetite nanoparticles for theranosis applications”, J. Magn. Magn. Mater., 323, 410–415 (2011)                                                            
  2. L. Granato, S. Laurent, L. Vander Elst, K. Djanashvili, J.A. Peters, R.N. Muller, “The Gd3+ complex of a conjugate of inulin and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(p-isothiocyanatoanilide), a potential kinetically stable blood-pool contrast agent for MRI”, Contrast Med. Mol. Imaging, 6, 482-491 (2011)                        
  3. M. Mahmoudi, S. Sardari, M.A. Shokrgozar, S. Laurent, P. Stroeve “Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles”, Nanoscale, 3, 1127–1138 (2011)  
  4. M. Mahmoudi, M. Hosseinkhani, S. Boutry, A. Simchi, H. Hosseinkhani, W.S. Journeay, K. Subramani, S. Laurent, “Magnetic Resonance Imaging Tracking of Stem Cells in Vivo Using Iron Oxide Nanoparticles as a Tool for the Advancement of Clinical Regenerative Medicine”, Chem. Rev., 111 (2), 253–280 (2011)             
  5. M. Othman, D. Desmaële, P. Couvreur, S. Laurent, L. Vander Elst, R.N. Muller, C. Bourgaux, T. Pouget, S. Lepêtre-Mouelhi, P. Durand, R. Gref, “Synthesis and physicochemical characterisation of new squalenoyl amphiphilic gadolinium complexes as nanoparticular contrast agents”, Organic & Biomolecular Chemistry, 9(11), 4367-86 (2011)    
  6. Q. Zhou, C. Henoumont, L. Vander Elst, S. Laurent, R.N. Muller, “NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga-complexes, “Cold” Analogs of PET/SPECT Tracers”, Contrast Med. Mol. Imaging, 6, 165-167 (2011)                              
  7. M. Mahmoudi, M. A. Shokrgozar. S. Bonakdar, M. K. Moghadam, S. Laurent, “Interaction of Bare and Gold-Coated Superparamagnetic Iron Oxide Nanoparticles with Fetal Bovine Serum”, JICS, 8(4), 944-950 (2011)
  8. S. Laurent, S. Dutz, U. Hafeli, M. Mahmoudi, "Superparamagnetic iron oxide nanoparticles for Hyperthermia", Adv Colloid & Interface Sci., 166, 8–23 (2011)
  9. M. Mahmoudi, K. Azadmanesh, S. Laurent, “Effect of Nanoparticles on cell-life cycle”, Chem. Rev., 111(5), 3407-3432 (2011)
  10. M. Mahmoudi, I. Lynch, R. Ejtehadi, M. Monopoli, S. Laurent, “Protein-Nanoparticles Interactions: Possibilities and Challenges”, Chem. Rev., 111(9), 5610-5637 (2011)
  11. M. Mahmoudi, M. A. Sahraian, S. Laurent, "Superparamagnetic iron oxide nanoparticles: Promises for diagnosis and treatment of multiple sclerosis", ACS Chemical Neuroscience, 2(3), 118–140 (2011)
  12. M. Mahmoudi, V. Serpooshan, S. Laurent, "Engineered Superparamagnetic Iron Oxide Nanoparticles for Biomolecular Imaging", Nanoscale, 3(8), 3007-3026 (2011)    
  13. H. Fattahi, S. Laurent, F. Liu, L. Vander Elst, R.N. Muller, “Magnetoliposomes as multimodal contrast agents for molecular imaging and theragnostics”, Nanomedicine, 6(3), 529-544 (2011)             
  14. F. Liu, S. Laurent, H. Fattahi, L. Vander Elst, R.N. Muller, “Superparamagnetic nanosystems based on iron oxide nanoparticles for biomedical imaging”,  Nanomedicine, 6(3), 519-528 (2011)               
  15. K. Kiyofuji, K. Tsunekawa, M. Yamashita, J. Yamashita, M. Fujie, K. Asai, T. Suyama, S. Ito, V.K. Reddy, M. Yamada, K. Ogawa, N. Ozaki, M. Sugiyama, M. Yamaoka, R. Makita, S. Nakamura, T. Aoki, G. Yu, K. Aoshima, N. Kamikage, Y. Takehara, H. Sakahara, H. Takayanagi, S. Laurent, C. Burtea, L. Vander Elst, R.N. Muller, “Preparation and Evaluation of Novel Sugar Dendritic Gd-DTPA Complexes for MRI Contrast Agents and Phospha Sugars for Anti-tumour Agents”, Adv. Mater. Res., 222, 217-220(2011)
  16. L. Larbanoix, C. Burtea, E. Ansciaux, S. Laurent, I. Mahieu, L. Vander Elst, R.N. Muller, “Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer’s disease. Comparison with two cyclic heptapeptides derived from a randomized phage display library », Peptides, 32(6), 1232-1243 (2011)                                                                         
  17. A. Kunzmann, B. Andersson, C. Vogt, N. Feliu, F. Ye, S. Gabrielsson, M.S. Toprak, T. Thurnherr, S. Laurent, M. Vahter, H. Krug, M. Muhammed, A. Scheynius, B. Fadeel, “Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells”, Toxicology & Applied Pharmacology,  253(2),  81-93  (2011)                                                                                                    
  18. A. Fornara, A. Recalenda, J. Qin, A. Sugunan, F. Ye, S. Laurent, R.N. Muller, J. Zou, A.R. Usama, M.S. Toprak, M. Muhammed, “Polymeric/inorganic multifunctional nanoparticles for simultabeous drug delivery and visualization”, Materials Research Society Symposium Proceedings, 1257, 1257-O04-03 (2010)
  19. N. Arsalania, H. Fattahi, S. Laurent, C. Burtea, L. Vander Elst, R.N. Muller, “Polyglycerol-grafted superparamagnetic iron oxide nanoparticles: highly efficient MRI contrast agent for liver and kidney imaging and potential scaffold for cellular and molecular imaging », Contrast Med. Mol. Imaging, 7, 185–194, (2012)                      
  20. M. Mahmoudi, S. Laurent, M.A. Shokrgozar, M. Hosseinkhani, “Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” versus Physicochemical Properties of Nanoparticles”, ACS Nano, 5(9), 7263-7276 (2011)                               
  21. M. Mahmoudi, H. Amiri, M.A. Shokrgozar, P. Sasanpour, B. Rashidian, S. Laurent, M. F. Casula, A. Lascialfari, “Raman active jagged-shaped gold-coated magnetic particles as a novel multimodal nanoprobe”, Chem. Commun., 47(37), 10404-10406 (2011)     
  22. G. Dehaen, P. Verwilst, S. Eliseeva, S. Laurent, L. Vander Elst, R. Muller, W. De Borggraeve, K. Binnemans, T. Parac-Vogt, "A heterobimetallic ruthenium-gadolinium complex as a potential agent for bimodal imaging", Inorg. Chem., 50(20), 10005-10014 (2011)                                                                                                                       
  23. G. Dehaen, S.V. Eliseeva, K. Kimpe, S. Laurent, L. Vander Elst, R.N. Muller, W. Dehaen, K. Binnemans, T.N. Parac-Vogt, “Self-assembled bimodal contrast agent with a titanium(IV) catecholate core”, Chem. Eur. J., 3577-3585 (2011)              
  24. P. Verwilst, S.V. Elisseva, S.Carron, L. Vander Elst, C. Burtea, G. Dehaen, S. Laurent, K. Binnemans, R.N. Muller, T.N. Parac-Vogt, W. M. De Borggraeve,  “A modular approach towards the synthesis of target-specific MRI contras agents”, Eur. J. Inorg. Chem., 3577-3585 (2011)               
  25. F. Lux, A. Mignot, P. Mowat, C. Louis, C. Bernhard, F. Denat, F. Boschetti, C. Brunet, R. Antoine, P. Dugourd, S. Laurent, L. Vander Elst, R. Muller, L. Sancey, V. Josserand, J.-L. Coll, V. Stupar, E. Barbier, C. Rémy, A. Broisat, C. Ghezzi, G. Le Duc, S. Roux, P. Perriat, O. Tillement. “Ultrasmall rigid platforms as multimodal probes for medical applications”, Angew. Chem., 50(51), 12299-12303 (2011)                                   
  26. G.A. Pereira, J.A. Peters, E. Terreno, D.D. Castelli, S. Aime, S. Laurent, L.Vander Elst, R.N. Muller, C.F.G.C. Geraldes, “Supramolecular Adducts of Negatively Charged Lanthanide(III) DOTP Chelates and Cyclodextrins Functionalized with Ammonium Groups : Mass Spectrometry and Nuclear Magnetic Resonance Studies”, Eur. J. Inorg. Chem, 12, 2087-2098 (2012)                                                                            
  27. S. Pinho, S. Laurent, J. Rocha, A. Roch, M.-H. Delville, L. Carlos, L. Vander Elst, R. Muller, C. Geraldes,"Relaxometric Studies of γ-Fe2O3@SiO2 Core Shell Nanoparticles: When the Coating Matters" J. Phys. Chem. C, 116(3), 2285-2291, (2012)      
  28. S. Laurent, C. Henoumont, L. Vander Elst, R.N. Muller, “Current Developments in contrast agents: Synthesis and Physico-Chemical Characterisation of Paramagnetic Contrast Agents for MRI”, Eur. J. Inorg. Chem, 12, 1889-1915 (2012)                                                       F.I.: 2.91
  29. S. Sharifi, S. Behzadi, S. Laurent, M. Laird Forrest, P. Stroeve, M. Mahmoudi, “Toxicity of Nanomaterials", Chem. Soc. Rev., 41, 2323–2343 (2012)                                   
  30. S. Laurent, S. Dutz, U. Hafeli, M. Mahmoudi, "Magnetic Fluid Hyperthermia: Focus on Superparamagnetic Iron Oxide Nanoparticles", Advances in Colloid and Interface Science, 166(1-2), 8-23 (2011)          
  31. S. Laurent, C. Burtea, C. Thirifays, U.O. Häfeli, M. Mahmoudi,"Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and "Cell Vision"",  PLoS ONE, 7(1), e29997, (2012)          
  32. S. Laurent, M. Mahmoudi, "Superparamagnetic Iron Oxide Nanoparticles: Promises for Diagnosis and Treatment of Cancer", Int J Mol Epidemiol Genet, 2(4):367-390 (2011)
  33. C. Henoumont, S. Laurent, R.N. Muller, L. Vander Elst, “Effect of Non-enzymatic Glycosylation on the MRI Contrast Agent Binding to Human Serum Albumin », J. Med Chem, 55 (8), 4015-4019 (2012)                                                                                                    
  34. S. Laurent,  M. Reza Ejtehadi,  M. Rezaei,  P.G. Kehoe, M. Mahmoudi, "Interdisciplinary Challenges and Promissing theragnosis Effects of Nanomaterials in Alzheimer’s Disease", RSC Adv., 2, 5008-5033 (2012)  
  35. G. Subbiahdoss, S. Sharifi, D.W. Grijpma, S. Laurent, H.C. van der Mei, M. Mahmoudi, H. J. Busscher, “Magnetic targeting of surface-modified superparamagnetic-iron-oxide nanoparticles yields antibacterial efficacy against biofilms of gentamicin-resistant staphylococci”, Acta Biomaterialia, 8, 2047–2055 (2012)                                            
  36. F. Ye, S. Laurent, A. Fornara, L. Astolfi, J. Qin, A. Roch,  A. Martini,  M. Toprak, R.N. Muller, M. Muhammed, “Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T2 contrast agent with tunable proton relaxivities”, Contrast Med. Mol. Imaging, 7(5):460-468 (2012)                                                
  37. P. Verwilst, S.V. Eliseeva, L. Vander Elst, C. Burtea, S. Laurent, S. Petoud, R.N. Muller, T.N. Parac-Vogt, W.M. De Borggraeve,"A Tripodal Ruthenium-Gadolinium Metallostar as a Potential αvβ3 Integrin Specific Bimodal Imaging Contrast Agent", Inorg. Chem., 51(11), 6405-6411 (2012)                                                    
  38. Y. Li, M. Beija, S. Laurent, L. Vander Elst, R.N. Muller, H.T.T. Duong, A.B. Lowe, T.P. Davis, C. Boyer, “Macromolecular Ligands for Gadolinium MRI Contrast Agents”, Macromolecules, 45 (10) , 4196-4204 (2012) 
  39. C. Burtea, S. Ballet, S. Laurent, O. Rousseaux, A. Dencausse, W. Gonzalez, M. Port, C. Corot, L. Vander Elst, R.N.  Muller, “Development of a Magnetic Resonance Imaging Protocol for the Characterization of Atherosclerotic Plaque by Using Vascular Cell Adhesion Molecule-1 and Apoptosis-Targeted Ultrasmall Superparamagnetic Iron Oxide Derivatives”, Arterioscler Thromb Vasc Biol. 32(6):e36-48 (2012)   
  40. C. Sclavons, S. Boutry, C. Burtea, S. Laurent, L. Vander Elst, R.N. Muller, “Phage display screening for tumor necrosis factor--binding peptides. Detection of inflammation in a mouse model of hepatitis”, International Journal of Peptides, Article ID 348409, 9 pages, 2013. doi:10.1155/2013/348409.                                                  
  41. E. Debroye, G. Dehaen, S. Eliseeva, S. Laurent, L. Vander Elst, R.N. Muller, K. Binnemans, T. Vogt, "A new metallostar complex based on an aluminium(III) 8-hydroxyquinoline core as a potential bimodal contrast agent", Dalton Transactions, 41, 10549–10556 (2012)           
  42. G. Dehaen, S. V.Eliseeva, P. Verwilst, S. Laurent,  L. Vander Elst, R.N. Muller, W. De Borggraeve, K. Binnemans, T.N. Parac-Vogt, “Tetranuclear d-f metallostars: synthesis, relaxometric and luminescent properties”,  Inorg. Chem., 51(16):8775-83 (2012) IF: 4.325
  43. M. Mahmoudi, S. N. Saeedi-Eslami, M.A. Shokrgozar, K. Azadmanesh, M. Hasanloo, H. Kalhor, C. Burtea, B. Rothen-Rutishauser, S. Laurent, S. Sheibani, H. Vali, “Cell “vision”: complementary factor of protein corona in nanotoxicology”, Nanoscale, 4(17):5461-8 (2012)                                 
  44. T. Courant, V.G. Roullin, C. Cadiou, M. Callewaert, M.C. Andry, C. Portefaix, C. Hoeffel, M. C. de Goltstein, M. Port, S. Laurent, L. Vander Elst, R. Muller, M. Molinari, F. Chuburu, « Hydrogels incorporating Gd-DOTA: towards highly efficient dual T1 /T2 MRI Contrast Agents », Angew. Chem., 51(36), 9119-22 (2012).                                
  45. M. Beija, Y. Li, S. Laurent, L. Vander Elst, R.N. Muller, A.B. Lowe, T.P. Davis, C. Boyer, Polymer-gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes, J. Mater. Chem., 22(40), 21382-21386 (2012)
  46. M. Abdolahi, D. Shahbazi-Gahrouei, S. Laurent, C. Sermeus, F. Firozian, B.J. Allen, S. Boutry, R.N. Muller, “Synthesis and in vitro evaluation of MR molecular imaging probes using J591 mAb-conjugated SPIONs for specific detection of prostate cancer”, Contrast Med. Mol. Imaging, 8(2), 175-84 (2013)                                                                        
  47. S. Laurent, C. Burtea, C. Thirifays, F. Rezaee, M. Mahmoudi, “Significance of cell ‘‘observer” and protein source in nanobiosciences”,  Journal of Colloid and Interface Science, 392, 431-45 (2013)                                                                   .                             
  48. S. Krol, R. Macrez, F. Docagne, G. Defer, S. Laurent, M. Rahman, M.M. Hajipour, P. Kehoe, M. Mahmoudi, “Therapeutic benefits from Nanoparticles: The potential significance of nanoscience in diseases to diseases with compromise to the blood brain barrier", Chem. Rev., 113 (3), 1877–190 (2013)                                                         
  49. D. Shahbazi-Gahrouei, M. Abdolahi, H. Zarkesh-Esfahani, S. Laurent, C. Sermeus, C. Gruettner, Journal of Biomedicine and Biotechnology, "Functionalized magnetic nanoparticles for the detection and quantitative analysis of cell surface antigen," BioMed Research International, 1-9 (2013)                                                                              
  50. T. Courant, V. G. Roullin, C. Cadiou, M. Callewaert, M. C. Andry, C. Portefaix, C. Hoeffel, M. C. de Goltstein, M. Port, S. Laurent, L. Vander Elst, R. N. Muller, M. Molinari, F Chuburu, “Biocompatible Nanoparticles and Gadolinium Complexes for MRI applications”, Comptes rendus chimie, 16(6),  531–539 (2013)                                                                            FI: 1.920
  51. S. Belaid, S. Laurent,  M. Vermeech, L. Vander Elst, D. Perez-Morga, R.N. Muller, “A novel approach to follow the formation of magnetic nanoparticles synthesized by thermal decomposition”, Nanotechnology, 24(5), Article number055705 (2013) 
  52. M. Mahmoudi, H.R. Kalhor, S. Laurent, I. Lynch, “
  53. Protein Fibrillation and Nanoparticle interactions: Opportunities and Challenges”, Nanoscale, 5, 2570-2588 (2013) 
  54. H.Y. Mao, S. Laurent, W. Chen, O. Akhavan, M. Imani, M. Mahmoudi, “Graphene: Promises, Facts, Opportunities, and Challenges in Nanomedicine", Chem Rev., 113, 3407-3424 (2013)                                                                                               
  55. Q. Zhou, C. Henoumont, L. Vander Elst, S. Laurent, R.N. Muller, Fluorometry, a fast screening technique for non-covalent binding of contrast agents to human serum albumin?, Contrast Med. Mol. Imaging, 8, 361–365 (2013)                        
  56. E. Lipani, S. Laurent, M. Surin, L. Vander Elst, P. Leclère, R.N. Muller, “High relaxivity and luminescent silica nanoparticles as multimodal agents for molecular imaging”, Langmuir, 29(10), 3419-3427 (2013)   
  57. N. Schleich, P. Sibret, P. Danhier, B. Ucakar, S. Laurent, R.Muller, C. Jérôme, B. Gallez, V.Préat, F. Danhier, “Dual paclitaxel/superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging”, Int. J. Pharmaceut. 447(1-2), 94-101 (2013)                                                                                    
  58. E. Debroye, S.V. Eliseeva, S. Laurent, L. Vander Elst, R.N. Muller, T.N. Parac-Vogt, Lanthanide(III) complexes of novel DTPA bisamide derivatives as potential agents for bimodal (optical/MR) imaging, Eur. J. Inorg. Chem, 14, 2629-2639 (2013)
  59. H. Mao, W. Chen, S. Laurent, C. Thirifays, C. Burtea, F. Rezaee, M. Mahmoudi, “Hard Corona Composition and Cellular Toxicities of the Graphene Sheets", Colloids and Surfaces B: Biointerfaces, 109, 212-218 (2013)
  60. S. Belaid, D. Stanicki, S. Laurent, L. Vander Elst, R.N. Muller, “Les agents de contraste nanoparticulaires pour l’imagerie médicale : conception, caractérisation et applications », Chimie Nouvelle, 112, 25-32 (2013)
  61. M. Darbandi, S. Laurent, M. Busch, Z.-A. Li, Y. Yuan, M. Krüger, M. Farle, M. Winterer, L. Vander Elst, R.N. Muller, H. Wende, “Blocked-micropores, surface functionalized, bio-compatible and silica coated iron oxide nanocomposites as advanced MRI contrast agent”, Journal of Nanoparticle Research, 15(5), 1-9 (2013)                            pact Factor
  62. S. Laurent, E.-P. Ng, C. Thirifays, L. Lakiss, J.M. Goupil, S. Mintova, C. Burtea, E. Oveisi, C. Hébert, M. Vries, M. Motazacker, F. Rezaee, M. Mahmoudi, “Corona protein composition and cytotoxicity evaluation of ultra-small zeolites synthesized from template free precursor suspensions", Toxicology Research, 2(4), 270-279 (2013)
  63. J.-L. Bridot, D. Stanicki, S. Laurent, S. Boutry, Y. Gossuin, P. Leclère, R. Lazzaroni, L. Vander Elst, R.N. Muller, “New carboxysilane coated iron oxide nanoparticles for non-specific cell labelling”, Contrast Med. Mol. Imaging, 8(6), 466–474,(2013)                I
  64. J. Rauch, W. Kolch, S. Laurent, M. Mahmoudi, “Big signals from small particles: regulation of cell signaling pathways by nanoparticles”, Chem Rev., 113, 3391-3406 (2013)   
  65. R. Naccache, P. Chevallier, J. Lagneux, Y. Gossuin, S. Laurent, L. Vander Elst, C. Chilian, J.A. Capobianco, M-A. Fortin, « high relaxivities ans strong vascular signal enhancement for NaGdF4 nanoparticles designed for dual MR/optical imaging”, Advanced Healthcare Materials, 2(11), 1478-1488 (2013)
  66. H. Amiri, S. Wan, M. Mahmoudi, L. Bordonali, A. Lascialfari, I. Lynch, S. Laurent, M.P. Monopoli, “Protein Corona Affects Relaxivity and MRI Contrast Efficiency of Magnetic Nanoparticles”, Nanoscale, 5(18), 8656-8665 (2013)                    
  67. M. Khajeh, S. Laurent, K. Dastafkan, "Nanoadsorbents: classification, preparation, and applications (with emphasis on aqueous media)”, Chem Rev., 113, 7728-7768 (2013)
  68. S. Sharifi, S. Daghighi, M. M. Motazacker, B. Badlou, B. Sanjabi, A. Akbarkhanzadeh, A.T. Rowshani, S. Laurent, M.P. Peppelenbosch, F. Rezaee, “Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes », Scientific Reports – Nature, 3 : 2173 | DOI: 10.1038/srep02173, 12 pages (2013)                                                                                                                                   
  69. A. Hannecart, S. Laurent, O. Sandre, D. Stanicki, L. Vander Elst, R.N. Muller, « Greffage de polymères thermosensibles à la surface de nanoparticules d’oxyde de fer », Chimie Nouvelle, 113, 04-09 (2013)
  70. J. Liu, C. Detrembleur, A. Debuigne, M.-C. De Pauw-Gillet, S. Mornet, L. Vander Elst, S. Laurent, C. Labrugère, E. Duguet, C. Jérôme, “Poly(acrylic acid)-block-poly(vinyl alcohol) Anchored Maghemite Nanoparticles Designed for Multi-stimuli Triggered Drug Release”, Nanoscale, 5, 11464-11477 (2013)                                                         
  71. A. Boulay, S. Laine, N. Leygue, E. Benoist, S. Laurent, L. Vander Elst, R.N. Muller, B. Mestre-Voegtle, C. Picard, “Synthesis and properties of a functionalized heterobimetallic Re(I)–Gd(III) complex as a potential dual-contrast agent for molecular imaging”, Tetrahedron Letters, 54(39), 5395-5398 (2013)                                  
  72. J. Morlieras, S. Dufort, L. Sancey, C. Truillet, A. Mignot, M. Dentamaro, S. Laurent, L. Vander Elst, R. Muller, R. Antoine, P. Dugourd, S. Roux, P. Perriat, F. Lux, J.C. Coll, O. Tillement, “Functionalization of small rigid plateforms with a cyclic RGD peptide for the targeting of tumors over-expressing v3 integrin”, Bioconj. Chem., 24(9), 1584-1597 (2013)                                                                                                                                   
  73. J. Lux, M. Chan, L. Vander Elst, E. Schopf, E. Mahmoud, S. Laurent, A. Almutairi, “Metal Chelating Crosslinkers Form Nanogels with High Chelation Stability”,  J. Mater. Chem. B, 1, 6359-6364 (2013)
  74. F. Liu, S. Laurent, A. Roch, L. Vander Elst, R.N. Muller, "Size-controlled synthesis of CoFe2O4 nanoparticles potential contrast agent for MRI and investigation on their size-dependent magnetic properties", Journal of Nanomaterials, art n° 462540 (2013) 
  75. E. Debroye, S. Laurent, L. Vander Elst, R.N. Muller, T.N. Parac-Vogt, “Magnetofluorescent Dysprosium Complexes and their Micelles as Potential Bimodal Agents for Magnetic Resonance and Optical Imaging”, Chemistry: A Europ J, 16019-16228 (2013)                                                                                                                                       
  76. S. Laurent, L. Vander Elst, C. Galaup, N. Leygue, S. Boutry, C. Picard, R.N. Muller, “Bifunctional Gd(III) and Tb(III) chelates based on a pyridine-bis(iminodiacetate) platform, suitable contrast agents for magnetic resonance and optical imaging”, Contrast Med. Mol. Imaging, 9, 300-312 (2014)                                              
  77. D. Stanicki, S. Boutry, S. Laurent, L. Wacheul, E. Nicolas, D. Crombez, L. Vander Elst, D.L.J. Lafontaine, R.N. Muller, "Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging", J. Mater. Chem. B, 2(4), 387-397 (2014)
  78. R. Guillet-Nicolas, M. Laprise-Pelletier, M.M. Nair, P. Chevallier, J. Lagueux, Y. Gossuin, S. Laurent, F. Kleitz, M.A. Fortin, « Manganese-impregnated mesoporous silica nanoparticles for signal enhancement in MRI cell labelling studies”, Nanoscale, 5, 11499-11511(2013)                                                                                                                          
  79. E. Debroye, S. Eliseeva, L. Vander Elst, S. Laurent, R.N. Muller, T. Parac-Vogt, “Micellar self-assemblies of gadolinium (III)/europium (III) amphiphilic complexes as potential contrast agents for bimodal imaging”, Dalton Trans., 43(9), 3589-3600 (2014)                                                                                           
  80. E. Debroye, M. Ceulemans, L. Vander Elst, S. Laurent, R.N. Muller, T. Parac-Vogt, “Controlled Synthesis of a Novel Heteropolymetallic Complex with Selectively Incorporated Lanthanide(III) Ions”, Inorg. Chem. 53(3), 1257-1259 (2014)              
  81. Y. Li, S. Laurent, L. Esser, L. Vander Elst, R.N. Muller, A.B. Lowe, C. Boyer, T.P. Davis, “The Precise Molecular Location of Gadolinium Atoms has a Significant Influence on the Efficacy of Nanoparticulate MRI Positive Contrast Agents”, Polymer Chemistry, 5(7), 2592-2601 (2014)                                                                           
  82. J. Liu, C. Detrembleur,M.-C. De Pauw-Gillet, S. Mornet, L. Vander Elst, S. Laurent, C. Jérôme, E. Duguet, “Remotely Heat-triggered Drug Release Systems based on Mesoporous Silica Nanoparticles Filled with a Maghemite Core and Phase-change Molecules as Gatekeepers”, J. Mater. Chem. B, 2(1), 59-70, (2014)
  83. J. Liu, C. Detrembleur, A. Debuigne, M.-C. De Pauw-Gillet, S. Mornet, L. Vander Elst, S. Laurent, E. Duguet, C. Jérôme, “Glucose- and pH-responsive Nanogels Crosslinked by Functional Superparamagnetic Maghemite Nanoparticles as Innovative Drug Delivery Systems”, J. Mater. Chem. B, 2(8), 1009-1023 (2014)
  84. G. Paul, Y. Prado, N. Dia, E. Rivière, S. Laurent, M. Roch, L. Vander Elst, R.N. Muller, L. Sancey, P. Perriat, O. Tillement, T. Mallah, L. Catala, MnII-containing coordination nanoparticles as highly efficient T1 contrast agents for Magnetic Resonance Imaging, Chem. Comm., 50 (51), 6740 – 6743 (2014)                                                          
  85. M.J. Hajipour, S. Laurent, F. Rezaee, M. Mahmoudi, Personnalized Protein Corona: "Key" Factor at the NanoBio Interface, Biomaterials Science, 2(9), 1210-1221 (2014)
  86. S. Laurent, A.A. Saei, S. Behzadi, M. Mahmoudi, “Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification, and applications in drug delivery”, Expert Opinion in Drug Delivery, 11(9), 1449-1470 (2014)               
  87. G. Rigaux, V.G. Roullin, C. Cadiou, C. Portefaix, L. Van Gulick, G. Boeuf, M.C. Andry, C. Hoeffel, L. Vander Elst , S. Laurent, R. Muller, M. Molinari, F. Chuburu, “A new Magnetic Resonance Imaging contrast agent loaded into poly(lacide-co-glycolide) nanoparticles for tumor long-term detection”, Nanotechnology, 25(44), 445103 (2014)
  88. Y. Li, H.T.T. Duong, S. Laurent, L. Vander Elst, R.N. Muller, J. Hu, A. Lowe, C. Boyer, T.P. Davis, “Nanoparticles based on star polymers as theranostic vectors: endosomal triggered drug release combined with MRI sensitivity”, Adv. Healthcare Mater., 4(1), 148–156 (2015)      
  89. S.N.M. Chilla, S. Laurent, L. Vander Elst, R.N. Muller,” Synthesis and characterization of new lanthanide-based MRI contrast agent, potential versatile tracer for multimodal imaging”, Tetrahedron, 70(35), 5450-5454 (2014)                                              
  90. P. Sakava, E. Talla, M. Chelea, A.T. Tchinda, M.E. Zeuko’o, S. Laurent, L. Vander Elst, F.M. Tagatsing, A.D.T. Atchade, G.A.J. Yaya, A. Atchade De Theodore, T.J. Mbafor, “Pentacyclic triterpernes and crude extracts with antimicrobial activity from Cameroonian brown propolis samples”, J. Applied Pharm. Sci., 4(06),  (accepté 28 Nov 2014), DOI:10.7324/JAPS.2014.4XXX
  91. V. Mogilireddy, I. Déchamps-Olivier, C. Alric, G. Laurent, S. Laurent, L. Vander Elst, R. Muller, R. Bazzi, S. Roux, O. Tillement, F. Chuburu, “Thermodynamic stability and kinetic inertness of a DTPA bisamide derivative grafted onto gold nanoparticles: guarantee of safety for in vivo MRI applications”, Contrast Media Mol Imaging, accepté (7 aout 2014), doi: 10.1002/cmmi.1616                                                                                  
  92. M. Callewaert, V.G. Roullin, C. Cadiou, E. Millart, M.C. Andry, C. Portefaix, C. Hoeffel, S. Laurent, L. Vander Elst, R.N. Muller, M. Molinari, F. Chuburu, “Tuning the composition of biocompatible Gd nanohydrogels to achieve hypersensitive dual T1/T2 MRI contrast agents”, J. Mater. Chem. B, 2, 6397-6405 (2014)
  93. E. Ansciaux, C. Burtea, S. Laurent, D. Nonclercq, L. Vander Elst, R.N. Muller, « In vitro and in vivo characterization of several functionalized ultrasmall particles of iron oxide, vectorized against amyloid plaques and potentially able to cross the blood-brain barrier: toward earlier diagnosis of Alzheimer’s disease by molecular imaging”, Contrast Media Mol Imaging,(DOI: 10.1002/cmmi.1626), accepted 4 Oct 2014 
  94. A. Walters, C. Billotey, A. Garofalo, C. Ulhaq-Bouillet, C. Lefèvre, J. Taleb, S. Laurent, L. Vander Elst, R.N. Muller, L. Lartigue, F. Gazeau, D. Felder-Flesch, S. Begin-Colin, “Mastering shape and composition of dendronized iron oxide nanoparticles to tailor magnetic resonance imaging and hyperthermia”, Chem. Mater., accepté (2014)
  95. A.Van Koninxloo, C. Henoumont, S. Laurent, R.N. Muller, L. Vander Elst, « NMR Chemical shift study of the interaction of selected peptides with liposomal and micellar models of apoptotic cells”, J. Biol. Inorg. Chem., 19:1367–1376 (2014)         
  96. M.J. Hajipour,   O. Akhavan,   A. Meidanchi,   S. Laurent, M. Mahmoudi, “Hyperthermia-induced protein corona improves the therapeutic effects of zinc ferrite spinel-graphene sheets against cancer”, RSC Adv., 4, 62557-62565 (2014)                
  97. A. Walter, A. Parat, A. Garofalo, S. Laurent, L. Vander Elst, R.N. Muller, T. Wu, E. Heuillard, E. Robinet, F. Meyer, D. Felder-Flesch, S. Begin-Colin, “Modulation of relaxivity, suspension stability and biodistribution of dendronized iron oxide nanoparticles as a function of the organic shell design”, Particles, accepté 06 décembre 2014
  98. Y.-X. J. Wáng, R. Arora, Y. Choi, H.-W. Chung, V.I. Egorov, J. Frahm, H. Kudo, S. Kuyumcu, S. Laurent, R. Loffroy, S. Maurea, S.K Morcos, Y. Ni, E.H.G. Oei, A. Sabarudin, X. Yu, “Implications of Web of Science Journal Impact Factor for scientific output evaluation in 16 Institutions and Investigators’ Opinion”, Quantitative Imaging in Medecine ans Surgery, 4(6): 453–461, (2014). doi:10.3978/j.issn.2223-4292.2014.11.16
  99. Y.-X. J Wáng, Y. Choi , Z. Chen, S. Laurent, S.L Gibbs, “From Bench to Clinic Studies on Molecular Imaging” in “A Special Issue with a Focus on Progress of Ultrasound and Radionuclide Imaging Technologies”, BioMed Research International, vol. 2014, Article ID 357258, 3 pages, 2014. doi:10.1155/2014/357258, Hindawi Publishing Corporation. 
  100. M.S.T. Diallo, M.A.Baldé, A. Camara, M.S. Traoré, M.L. Bah, A.S. Diallo, A.K. Camara, S.  Laurent, A. Roch, R.N. Muller, L. Maes, L. Pieters, A.M. Baldé, « Ethnomedical, hytochemical and biological investigations of Margaritaria discoidea (Baill.) Webster, a plant species widely used in Guinean traditional medicine”, Journal of Plant Sciences, 3(1-2): 40-46 (2015)
  101. A. Walter, A. Garofalo, A. Parat, E. Voirin, J. Taleb, P. Bonazza, G. Pourroy, C. Billotey, S. Laurent, L. Vander Elst, R. N. Muller, S Begin-Colin, D. Felder-Flesch, “Validation of a dendron concept to tune colloidal stability, MRI relaxivity and bioelimination of functional nanoparticles”, J. Mater. Chem. B, 3(8), 1484-1494 (2015)
  102. D. Stanicki, L. Vander Elst, R. N. Muller, S. Laurent,  "Synthesis and Processing of Magnetic Nanoparticles", Curr Op Chem Eng. 6, 7-14 (2015)
  103. A. Boulay, C. Deraeve, L. Vander Elst, N. Leygue, O. Maury, S. Laurent, R.N. Muller, B. Mestre-Voegtlé, C. Picard, “A Terpyridine-Based Heteroditopic Ligand for RuIILn3III Metallostar Architectures (Ln = Gd, Eu, Nd, Yb) with MRI/Optical or Dual Optical Responses”, Inorg Chem, 54(4), 1414-1425 (2015)                                                       
  104. M. Harris, S. Carron, L. Vander Elst, S. Laurent, R.N. Muller, T. Vogt, « Magnetofluorescent micellar complexes of terbium(III) as potential bimodal contrast agents for magnetic resonance and optical imaging", Chem Comm., 51, 2984-2986 (2015)                                                                                                                                    
  105. A. Hannecart, D. Stanicki, L. Vander Elst, R.N. Muller, S. Lecommandoux, J. Thévenot, C. Bonduelle, A. Trotier, P. Massot, S. Miraux, O. Sandre, S. Laurent, “Nano-thermometer with Thermo-sensitive Polymer Grafted USPIOs behaving as Positive Contrast Agents in low-field MRI”, Nanoscale, 7 (8), pp. 3754-3767 (2015)       
  106. M. Kačenka, O. Kaman, S. Kikerlová, Z. Jirák, D. Jirák, V. Herynek, J. Černý, F. Chaput, S. Laurent, I. Lukeš, “Fluorescent magnetic nanoparticles with enhanced chemical stability for bioapplications: the manganite coated by rhodamine tagged silica”, Journal of Colloid & Interface Science. 447, 97-106 (2015)                                                   
  107. M. S. Sharifi, H. Seyednejad, S. Laurent, M. Mahmoudi, “Superparamagnetic iron oxide nanoparticle for in vivo molecular and cellular imaging”, Contrast Media Mol Imaging, accepted (2015) 
  108. O. Mashinchian, L.-A. Turner, M.J. Dalby, S. Laurent, M.A. Shokrgozar, S. Bonakdar, M. Imani, M. Mahmoudi, “Regulation of stem cell fate by nanomaterial substrates”, Nanomedicine, 10(5), accepted (2015) 
  109. C. Burtea, S. Laurent, S. Delcambre, C. Sermeus, D. Flamez, M-C Beckers, L. Vander Elst, D.L. Eizirik, R.N. Muller, “Peptide targeting of (FXYD2)ga as a highly specific biomarker of pancreatic beta cells”, Contrast Media & Mol. Imaging, accepted
  110. S. Laurent, D. Stanicki, S. Boutry, J.C. Roy,  L. Vander Elst, R.N. Muller, “ Development of a New Molecular Probe for the Detection of Inflammatory Process”, J Mol Biol & Mol Imaging, 2(1), id1013, 4 pages (2015).
  111. J. Raheb, M.J. Hajipour, O. Mashinchian, O. Akhavan, M. Abdolahad, S. Arjmand, M. Rahman, S. Laurent, M. Mahmoudi, “Personalized, Disease-Specific Protein Corona Influences the Therapeutic Impact of Graphene Oxide”, Nanoscale, accepted (2015)
  112. V. Pourcelle, S. Laurent, A. Welle, N. Vriamont, D. Stanicki, L. Vander Elst, R. Muller, J. Marchand-Brynaert, “Functionalization of the PEG corona of nanoparticles by clip photochemistry in water: application to the grafting of RGD ligands on PEGylated USPIO imaging agent”, Bioconj Chem, 26 (5),  822-829 (2015)
  113. T. Javanbakht, S. Laurent, D. Stanicki, K.J. Wilkinson, “ Relating the surface physicochemical properties of superparamagnetic iron oxide nanoparticles (SPIONs) to bactericidal effect towards a Streptococcus mutans biofilm”, accepted (2015)
  114. C. Vogt, M. Pernemalm, P. Kohonen, S. Laurent, K. Hultenby, M. Vahter, J. Lehtiö, M. Toprak, B. Fadeel, “Proteomics analysis reveals distinct corona composition on magnetic nanoparticles with different surface coatings: implications for interactions with primary human macrophages, PLOS One, accepté, PONE-D-14-50625R1 (2015)
  115. M. Harris, S. Carron, L. Vander Elst, S. Laurent, T. Vogt, « Magnetofluorescent nanoaggregates incorporating terbium (III) complexes as potential bimodal contrast agents for magnetic resonance and optical imaging", Eur. J. Inorg. Chem., accepted (2015)
  116. S. Carron, M. Bloemen, L. Vander Elst, S. Laurent, T. Verbiest, T.N. Parac-Vogt, “Potential theranostic and multimodal iron oxide nanoparticles decorated with rhenium-bipyridine and -phenanthroline complexes”, J. Mater. Chem. B, 3 (21), 4370-4376 (2015)
  117. D.A.Mbeh, L.K. Mireles, D. Stanicki, K.Maghni, S. Laurent, E. Sacher, L. Yahia, Human alveolar epithelial cell responses to core-shell superparamagnetic iron oxide nanoparticles (spions), 31 (13), Langmuir, 3829-3839 (2015)
  118. M.J. Hajipour, J. Raheb, O. Akhavan, S. Arjmand, O. Mashinchian, M. Rahman, M. Abdolahad, V. Serpooshan, S. Laurent, M. Mahmoudi, “Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide”, Nanoscale, 7(19), 8978-8994 (2015)
  119. C. Henoumont, S. Laurent, R.N. Muller, L. Vander Elst, “La spectroscopie HR-MAS: un nouvel outil pour la caractéristion des nanoparticules de fer », Chimie Nouvelle, 118, 8-17 (2015)
  120. A. Alkilany, R. Azhdarzadeh, M Saei, S. Sharifi, M.J. Hajipour, S. Laurent, M. Mahmoudi, Nanomedicine, accepté (2015)
  121. F. Liu, S. Laurent, L. Vander Elst, R.N. Muller, « Synthesis of CdTe QDs by hydro-thermal method, with tunable emission fluorescence”, Materials Research Express, accepted (2015)
  122. M. Helvenstein, D. Stanicki, S. Laurent, B. Blankert, “Interaction between iron oxide nanoparticles and HepaRG cells: a preliminary In vitro evaluation”, Journal of Nanomaterials, accepted (2015)
  123. E. Talla , D. Daouda, J.N. Nyemb, S. Laurent , L. Vander Elst, B. Dabole, T.J. Mbafor, “Two new compounds from stem barks of Vepris heterophylla (Engl.) R. Let. (Rutaceae)”, Journal of Chemical and Pharmaceutical Research, 7(7), 553-557 (2015)  

 

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