Education

Biography

Professor Horace Loh received his Ph.D. in biochemistry from the University of Iowa in 1965.  He was a faculty member at the University of California, San Francisco Medical Center (UCSF) until 1988, when he became the Head of the Department of Pharmacology at the University of Minnesota.  Dr. Loh served in this capacity and also as the Frederick and Alice Stark Professor in Neuroscience until 2012.  Currently he is a Regents Professor in the Department of Pharmacology, at the University of Minnesota.

Dr. Loh has served as a member of the editorial or editorial advisory board for more than 20 professional journals including Current Opinion in Pharmacology.  He has also served as an associate editor of the Annual Review of Pharmacology and Toxicology, a position he held for over 20 years.  Dr. Loh has over 645 original publications.

His professional associations include membership in the American College of Neuropsychopharmacology, Society of Chinese Bioscientists in America, College on Problems of Drug Dependence, American Society of Pharmacology and Experimental Therapeutics, and Western Pharmacology Society.

Dr. Loh has been recognized by the University of Minnesota as the first recipient of the Medical School’s Distinguished Senior Scientist Award, and as one of the first inductees into the Academic Health Center’s Academy of Excellence.  In 2010, he was named Regents Professor, the University’s highest faculty honor. He has received many honors including an honorary doctorate from the China Medical University (R.O.C); election to the membership of Academia Sinica (R.O.C.); the University of Iowa Carver College of Medicine’s Distinguished Alumnus Award; the Nathan B. Eddy Memorial Award from the College on Problems of Drug Dependence; Otto Krayer Award in Pharmacology from the American Society for Pharmacology and Experimental Therapeutics; the Award of Excellence in Pharmacology from the Pharmaceutical Research and Manufacturers of America Foundation; and the Method to Extend Research in Time Award, Research Scientist Award, and Career Development Award, from the National Institutes of Health; as well as the very first Presidential Award, and later the Lifetime Achievement Award from the Society of Chinese Bioscientists in America.

Research Interest

• Molecular neuropharmacology and biochemical pharmacology
• Specializing in the mechanism of narcotic actions, tolerance and physical dependence.
• Pharmacology of opioid and endorphins and subsequently in opioid receptor signaling
• Pharmacological regulation of opioid receptor activities; receptor gene cloning; transcriptional, translational and epigenetic regulation of opioid receptor genes and their relationship to the pharmacological activity of the opioid drugs.

Scientific Activities

Employment History

Professional Activities

• Standing Committee Member, National Institute on Drug Abuse (NIDA) K Scientific Review Group (2006-2010)
• Member, NIDA Special Emphasis Panel (ZDA1-MXG-S-19) on Prescription Opioid Use and Abuse in the Treatment of Pain, NIH (2006)
• American College of Neuropsychopharmacology, Life Fellow (1980-present)
• American Society of Pharmacology and Experimental Therapeutics (1970-present)
• Western Pharmacology Society (1965-present)
• Society of Chinese Bioscientists in America (1985-present)
• College on Problems of Drug Dependence, Charter Fellow (1991-present)
• Member of International Journal of Research in Pharmacology Studies: Editorial Board (2017-present)
• Basic, Applied Pharmacy and Pharmacology: Honorable Editor (2017-present)
• Journal of Pharmacology and Toxicology Research: Member, Editorial Board (2015-present)
• Journal of In Silico & In Vitro Pharmacology: Member, Editorial Board (2015-present)
• Journal of Toxicology and Risk Assessment: Member, Editorial Board (2015-present)

Honors And Awards

• Co-recipient, 13th National Innovation Award, Taiwan, ROC (2016)
• Appointed Member of the International Tang Prize Selection Committee in Biopharmaceutical Science,  ROC (2015-2016)
• Recipient of the Lifetime Achievement Award, Society of Chinese Bioscientists in America (2015)
• Awarded the Doctorate of Philosophy, Honoris Causa, China Medical University, Taiwan ROC (2015)
• Appointed Regents Professor, University of Minnesota (2010-present)
• Holder of the Dr. Frederick and Alice Stark Chair in Neuroscience, Medical School, University of Minnesota (1990-2013)
• Distinguished Chair Professor at Taipei Medical University, Taiwan, ROC (2013)
• Recipient of the First University of Minnesota’s Medical School Senior Investigator Award (2010)
• Recipient of the Founders’ Award from the International Narcotics Research Conference (INRC), 2007
• Recipient of the University of Iowa Carver College of Medicine’s Distinguished Alumnus Award for Achievement, 2007
• Co-Recipient of The Japanese Society of Toxicology “Tanabe Award,” 2006
• “Recognition of Excellence” for Outstanding Contributions and Achievements in Teaching, Research, or Service, from the Academic Health Center, University of Minnesota, 2002. Dr. Loh was in the first group (one of 4) to receive this honor when this program was initiated.
• Recipient of the Nathan B. Eddy Memorial Award for Lifetime Excellence in Addiction Research, from the College on Problems of Drug Dependence (CPDD), 2002
• Recipient of the 1999 Otto Krayer Award in Pharmacology, from the American Society for Pharmacology and Experimental Therapeutics (ASPET)
• Recipient of the First “Award in Excellence for Basic Pharmacology” from the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation, 1999
• Recipient of the First “Presidential Award” from the Society of Chinese Bioscientists in America (SCBA), 1999
• Elected member of Academia Sinica of the Republic of China (1986)
• Recipient Humboldt Research Award for Senior Scientists, Germany (1976)
• National Institutes of Health (NIH) Method to Extend Research in Time (MERIT) Award (National Institute on Drug Abuse) (1988-1998) (Dr. Loh was one of three of the very first scientists to receive this award when the program was initiated.)
• National Institutes of Health (NIH) Research Scientist Award (1983-88, 1989-94, 1994-99, 1999-04, 2004-09, five five-year terms)
• National Institutes of Health (NIH) Career Development Award (1973-78, 1978-83, two five-year terms)

Publications

1. Yee, A; Ng, BS; Hashim, HMH; Danaee, M; Loh, HH (2017) Cultural adaptation and validity of the Malay version of the brief psychiatric rating scale (BPRS-M) among patients with schizophrenia in a psychiatric clinic. BMC Psychiatry 17: 384.
2. Zhang, Y; Kibaly, C; Xu, C; Loh, HH; Law, PY (2017) Temporal effect of manipulating NeuroD1 expression with the synthetic small molecule KHS101 on morphine contextual memory. Neuropharmacology 126: 58-69.
3. Zhang, L; Kibaly, C; Wang, YJ; Xu, C; Song, KY; Mc Garrah, PW; Loh, HH; Liu, JG; Law, PY (2017) Src-dependent phosphorylation of μ-opioid receptor at Tyr336 modulates opiate withdrawal. EMBO Mol Med 9: 1521-1536.
4. Lee, DS; Law, PY; Ln, W; Loh, HH; Song, KY; Choi, HS (2017) Differential regulation of mouse and human Mu opioid receptor gene depends on the single stranded DNA structure of its promoter and α-complex protein 1. Biomed Rep 6: 532-538.
5. Loh, HH; Lim, LL; Yee, A; Loh, HS; Vethakkan, SR (2017) Effect of Vitamin D replacement in Primary Hyperparathyroidism with concurrent Vitamin D deficiency: a systematic review and meta-analysis. Minerva Endocrinol.
6. Chao, PK; Ueng, SH; Ou, LC; Yeh, TK; Chang, WT; et al. (2017) 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine. Anesthesiology 126 : 952-966.
7. Kibaly, C; Lin, HY; Loh, HH; Law, PY (2017) Spinal or supraspinal phosphorylation deficiency at the OR C-terminus does not affect morphine tolerance in vivo. Pharmacol Res 119: 153-168.
8. Wagley, Y; Law, PY; Wei, LN; Loh, HH (2017) Epigenetic Activation of μ-Opioid Receptor Gene via ncreased Expression and Function of Mitogen- and Stress-Activated Protein Kinase 1. Mol Pharmacol 91: 357-372.
9. Ke, YY; Huang, YH; Chien, WC; Loh, HH; Chuang, JY; Yeh, SH (2017) Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers. Biochim Biophys Acta 1865: 336-343.
10. Loh, HH; Kamaruddin, NA; Zakaria, R; Sukor, N (2016) Improvement of Bone Turnover Markers and Bone Mineral Density following treatment of Primary Aldosteronism. Minerva Endocrinol.
11. Hwang, CK; Wagley, Y; Law, PY; Wei, LN; Loh, HH (2017) Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP). Gene 598: 113-130.
12. Chen, SR; Ke, YY; Yeh, TK; Lin, SY; Ou, LC; Chen, SC; Chang, WT; Chang, HF; Wu, ZH; Hsieh, CC; Law, PY; Loh, HH; Shih, C; Lai, YK; Yeh, SH; Ueng, SH (2017) Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists. Eur J Med Chem 126: 202-217.
13. Kibaly, C; Loh, HH; Law, PY (2016) A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain. Int Rev Cell Mol Biol 327: 89-161.
14. Yang, PP; Yeh, GC; Yeh, TK; Xi, J; Loh, HH; Law, PY; Tao, PL (2016) Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice. Pharmacol Res 111: 867-876.
15. Song, KY; Choi, HS; Law, PY; Wei, LN; Loh, HH (2017) Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1. J Cell Physiol 232: 576-584.
16. Zhang, Y; Loh, HH; Law, PY (2016) Effect of Opioid on Adult Hippocampal Neurogenesis. ScientificWorldJournal.
17. Zhang, Y; Xu, C; Zheng, H; Loh, HH; Law, PY (2016) Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors. PLoS One 11: e0153628.
18. Huang, Z; Liang, L; Li, L; Xu, M; Li, X; Sun, H; He, S; Lin, L; Zhang, Y; Song, Y; Yang, M; Luo, Y; Loh, HH; Law, PY; Zheng, D; Zheng, H (2016) Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels. Lipids Health Dis 15: 47.
19. Loh, HH; Yee, A; Loh, HS; Sukor, N; Kamaruddin, NA (2017) The natural progression and outcomes of adrenal incidentaloma: a systematic review and meta-analysis. Minerva Endocrinol 42: 77-87.
20. Xu, C; Loh, HH; Law, PY (2016) Effects of addictive drugs on adult neural stem/progenitor cells. Cell Mol Life Sci 73: 327-48.
21. Loh, HH; Yee, A; Loh, HS; Sukor, N; Kamaruddin, NA (2016) Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis. Prim Care Diabetes 10: 210-9.
22. Yang, PP; Yeh, GC; Huang, EY; Law, PY; Loh, HH; Tao, PL (2015) Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice. J Biomed Sci 22 81
23. Loh, HH; Norlela, S; Nor Azmi, K (2015) Reappraisal of bovril as a source of arginine in the arginine stimulation test for growth hormone deficiency. Med J Malaysia 70: 208-9.
24. Wang, Y; Ge, YH; Wang, YX; Liu, T; Law, PY; Loh, HH; Chen, HZ; Qiu, Y (2015) Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12. CNS Neurosci Ther 21: 591-8.
25. Kibaly, C; Kam, AY; Loh, HH; Law, PY (2016) Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion. Biol Psychiatry 79: 906-16.
26. Xu, C; Zheng, H; Loh, HH; Law, PY (2015) Morphine Promotes Astrocyte-Preferential Differentiation of Mouse Hippocampal Progenitor Cells via PKCε-Dependent ERK Activation and TRBP Phosphorylation. Stem Cells 33: 2762-72.
27. Lee, PT; Chao, PK; Ou, LC; Chuang, JY; Lin, YC; Chen, SC; Chang, HF; Law, PY; Loh, HH; Chao, YS; Su, TP; Yeh, SH (2014) Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling. Nucleic Acids Res 42: 13012-25.
28. Hwang, CK; Wagley, Y; Law, PY; Wei, LN; Loh, HH (2015) Analysis of epigenetic mechanisms regulating opioid receptor gene transcription. Methods Mol Biol 1230 39-51.
29. Wang, Y; Wang, YX; Liu, T; Law, PY; Loh, HH; Qiu, Y; Chen, HZ (2015) μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling. CNS Neurosci Ther 21 8-14.
30. Cheng, MF; Ou, LC; Chen, SC; Chang, WT; Law, PY; Loh, HH; Chao, YS; Shih, C; Yeh, SH; Ueng, SH (2014) Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists. Bioorg Med Chem 22: 4694-703.
31. Li, W; He, S; Zhou, Y; Li, Y; Hao, J; Zhou, X; Wang, F; Zhang, Y; Huang, Z; Li, Z; Loh, HH; Law, PY; Zheng, H (2014) Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms. Biol Psychiatry 76: 775-84
32. Xu, C; Zhang, Y; Zheng, H; Loh, HH; Law, PY (2014) Morphine modulates mouse hippocampal progenitor cell lineages by upregulating miR-181a level. Stem Cells 32: 2961-72.
33. Kao, JH; Gao, MJ; Yang, PP; Law, PY; Loh, HH; Tao, PL (2015) Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord. Br J Pharmacol 172: 630-41.
34. Loh, HH; Mohd Noor, N (2014) The use of hemodialysis in refractory hypercalcemia secondary to parathyroid carcinoma. Case Rep Crit Care.
35. Yan, YH; Wang, Y; Zhao, LX; Jiang, S; Loh, HH; Law, PY; Chen, HZ; Qiu, Y (2014) Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. Neurosci Lett 566: 231-235.
36. Feng, X; Wu, CY; Burton, FH; Loh, HH; Wei, LN (2014) β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia. Cell Death Differ 21: 397-406
37. Loh, HH; Tan, F (2013) Pancytopenia in a Patient with Grave's Disease. Med J Malaysia 68: 372-3.
38. Qiu, Y; Zhao, W; Wang, Y; Xu, JR; Huie, E; Jiang, S; Yan, YH; Loh, HH; Chen, HZ; Law, PY (2014) FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor. Mol Pharmacol 85: 37-49.
39. Zhang, L; Loh, HH; Law, PY (2013) A novel noncanonical signaling pathway for the μ-opioid receptor. Mol Pharmacol 84: 844-53
40. Kang, DH; Song, KY; Wei, LN; Law, PY; Loh, HH; Choi, HS (2013) Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences. Int J Mol Med 32: 1187-94.
41. Law, PY; Reggio, PH; Loh, HH (2013) Opioid receptors: toward separation of analgesic from undesirable effects. Trends Biochem Sci 38: 275-82.
42. Wagley, Y; Hwang, CK; Lin, HY; Kam, AF; Law, PY; Loh, HH; Wei, LN (2013) Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells. Biochim Biophys Acta 1833: 1476-88.
43. Zheng, H; Loh, HH; Law, PY (2013) Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods Enzymol 522: 391-408.
44. Song, KY; Choi, HS; Law, PY; Wei, LN; Loh, HH (2013) Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation. RNA Biol 10: 256-66.
45. Zheng, H; Zhang, Y; Li, W; Loh, HH; Law, PY (2013) NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction. Neuropsychopharmacology 38: 770-7.
46. Wu, Q; Hwang, CK; Zheng, H; Wagley, Y; Lin, HY; Kim, DK; Law, PY; Loh, HH; Wei, LN (2013) MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment. FASEB J 27: 522-35.
47. Zheng, H; Law, PY; Loh, HH (2012) Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Front Genet 3: 113.
48. Flaisher-Grinberg, S; Persaud, SD; Loh, HH; Wei, LN (2012) Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc. Proc Natl Acad Sci 109: 9167-72.
49. Loh, HH; Tan, CH (2012) Acute renal failure and posterior reversible encephalopathy syndrome following multiple wasp stings: a case report. Med J Malaysia 67: 133-5.
50. Kang, DH; Song, KY; Choi, HS; Law, PY; Wei, LN; Loh, HH (2012) Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequence. Gene 501: 33-8.
51. Zheng, H; Pearsall, EA; Hurst, DP; Zhang, Y; Chu, J; Zhou, Y; Reggio, PH; Loh, HH; Law, PY (2012) Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. BMC Cell Biol 13: 6.
52. Chou, SH; Kao, JH; Tao, PL; Law, PY; Loh, HH (2012) Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway. Synapse 66 694-704.
53. Zheng, H; Zou, H; Liu, X; Chu, J; Zhou, Y; Loh, HH; Law, PY (2012) Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. J Lipid Res 53: 1153-62.
54. Lin, HY; Law, PY; Loh, HH (2012) Activation of protein kinase C (PKC)α or PKCε as an approach to increase morphine tolerance in respiratory depression and lethal overdose. J Pharmacol Exp Ther 341: 115-25.
55. Hwang, CK; Wagley, Y; Law, PY; Wei, LN; Loh, HH (2012) MicroRNAs in opioid pharmacology. J Neuroimmune Pharmacol 7 808-19
56. Liu, XY; Liu, ZC; Sun, YG; Ross, M; Kim, S; Tsai, FF; Li, QF; Jeffry, J; Kim, JY; Loh, HH; Chen, ZF (2011) Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Cell 147: 447-58.
57. Choe, CY; Kim, H; Dong, J; van Wijnen, AJ; Law, PY; Loh, HH (2011) The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element. Gene 487: 52-61.
58. Song, KY; Choi, HS; Law, PY; Wei, LN; Loh, HH (2012) Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F. Cell Mol Life Sci 69: 599-610.
59. Zheng, H; Chu, J; Zhang, Y; Loh, HH; Law, PY (2011) Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem 286: 12724-33.
60. Kim, DK; Hwang, CK; Wagley, Y; Law, PY; Wei, LN; Loh, HH (2011) p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide. J Neurochem 116: 1077-87.
61. Kam, AY; Liao, D; Loh, HH; Law, PY (2010) Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits. J Neurosci 30: 15304-16.
62. Choe, CY; Dong, J; Law, PY; Loh, HH (2011) Differential gene expression activity among species-specific polypyrimidine/polypurine motifs in mu opioid receptor gene promoters. Gene 471: 27-36.
63. Wei, LN; Loh, HH (2011) Transcriptional and epigenetic regulation of opioid receptor genes: present and future. Annu Rev Pharmacol Toxicol 51: 75-97.
64. Zhao, H; Xiao, S; Kong, X; Wang, J; Cao, X; Gencheng, W; Loh, HH; Law, PY (2011) Neuron-glial cell communication in the traumatic stress-induced immunomodulation. Synapse 65: 433-40.
65. Sanchez-Simon, FM; Zhang, XX; Loh, HH; Law, PY; Rodriguez, RE (2010) Morphine regulates dopaminergic neuron differentiation via miR-133b. Mol Pharmacol 78: 935-42.
66. Kao, JH; Chen, SL; Ma, HI; Law, PY; Tao, PL; Loh, HH (2010) Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm. J Pharmacol Exp Ther 334: 739-45.
67. Zheng, H; Zeng, Y; Chu, J; Kam, AY; Loh, HH; Law, PY (2010) Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. J Neurosci 30: 8102-10.
68. Zheng, H; Chu, J; Zeng, Y; Loh, HH; Law, PY (2010) Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. J Biol Chem 285: 21994-2002.
69. Chen, SL; Ma, HI; Han, JM; Lu, RB; Tao, PL; Law, PY; Loh, HH (2010) Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene. J Biomed Sci 17: 28.
70. Chen, YL; Monteith, N; Law, PY; Loh, HH (2010) Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation. Biochem Biophys Res Commun 396: 294-8.
71. Hwang, CK; Kim, CS; Kim, DK; Law, PY; Wei, LN; Loh, HH (2010) Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells. Mol Pharmacol 78: 58-68.
72. Shen, X; Purser, C; Tien, LT; Chiu, CT; Paul, IA; Baker, R; Loh, HH; Ho, IK; Ma, T (2010) mu-Opioid receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization. J Neurosci Res 88: 2294-302.
73. Tsai, NP; Tsui, YC; Pintar, JE; Loh, HH; Wei, LN (2010) Kappa opioid receptor contributes to EGF-stimulated neurite extension in development. Proc Natl Acad Sci 107: 3216-21.
74. Zheng, H; Loh, HH; Law, PY (2010) Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications. IUBMB Life 62: 112-9.
75. Chu, J; Zheng, H; Zhang, Y; Loh, HH; Law, PY (2010) Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cell Signal 22: 684-96.
76. Tao, PL; Law, PY; Loh, HH (2010) Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor. IUBMB Life 62: 103-11.
77. Ge, X; Qiu, Y; Loh, HH; Law, PY (2009) GRIN1 regulates micro-opioid receptor activities by tethering the receptor and G protein in the lipid raft. J Biol Chem 284: 36521-34.
78. Zheng, H; Zeng, Y; Zhang, X; Chu, J; Loh, HH; Law, PY (2010) mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Mol Pharmacol 77: 102-9.
79. Song, KY; Choi, HS; Hwang, CK; Kim, CS; Law, PY; Wei, LN; Loh, HH (2009) Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1). Cell Mol Life Sci 66: 2933-42.
80. Hwang, CK; Song, KY; Kim, CS; Choi, HS; Guo, XH; Law, PY; Wei, LN; Loh, HH (2009) Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor. J Cell Mol Med 13: 3591-615.
81. Zhao, H; Cao, X; Wu, G; Loh, HH; Law, PY (2009) Neurite outgrowth is dependent on the association of c-Src and lipid rafts. Neurochem Res 34: 2197-205.
82. Song, KY; Kim, CS; Hwang, CK; Choi, HS; Law, PY; Wei, LN; Loh, HH (2010) uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression. J Cell Mol Med 14: 1113-24.
83. Lin, H; Higgins, P; Loh, HH; Law, PY; Liao, D (2009) Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors. Neuropsychopharmacology 34: 2097-111.
84. Ge, X; Loh, HH; Law, PY (2009) mu-Opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I. Mol Pharmacol 75: 1307-16.
85. Choi, HS; Hwang, CK; Song, KY; Law, PY; Wei, LN; Loh, HH (2009) Poly(C)-binding proteins as transcriptional regulators of gene expression. Biochem Biophys Res Commun 380: 431-6.
86. Wu, Q; Zhang, L; Law, PY; Wei, LN; Loh, HH (2009) Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b. Mol Pharmacol 75: 744-50.
87. Zhang, L; Zhao, H; Qiu, Y; Loh, HH; Law, PY (2009) Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. J Biol Chem 284 1990-2000.
88. Lin, YC; Flock, KE; Cook, RJ; Hunkele, AJ; Loh, HH; Ko, JL (2008) Effects of trichostatin A on neuronal mu-opioid receptor gene expression. Brain Res 1246: 1-10.
89. Wu, Q; Law, PY; Wei, LN; Loh, HH (2008) Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b. FASEB J 22: 4085-95.
90. Kim, CS; Hwang, CK; Song, KY; Choi, HS; Kim, DK; Law, PY; Wei, LN; Loh, HH (2008) Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation. Biochim Biophys Acta 1783: 1835-46.
91. Zheng, H; Chu, J; Qiu, Y; Loh, HH; Law, PY (2008) Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci 105: 9421-6.
92. Chu, J; Zheng, H; Loh, HH; Law, PY (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal 20: 1616-24.
93. Dai, X; Brunson, CD; Rockhold, RW; Loh, HH; Ho, IK; Ma, T (2008) Gender differences in the antinociceptive effect of tramadol, alone or in combination with gabapentin, in mice. J Biomed Sci 15: 645-51.
94. Choi, HS; Song, KY; Hwang, CK; Kim, CS; Law, PY; Wei, LN; Loh, HH (2008) A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene. Mol Cell Proteomics 7: 1517-29.
95. Chen, YL; Law, PY; Loh, HH (2008) The other side of the opioid story: modulation of cell growth and survival signaling. Curr Med Chem 15: 772-8.
96. Chen, YL; Law, PY; Loh, HH (2008) NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression. Biochem Biophys Res Commun 368: 755-60.
97. Choi, HS; Hwang, CK; Kim, CS; Song, KY; Law, PY; Loh, HH; Wei, LN (2008) Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1. J Cell Mol Med 12: 2319-33.
98. Park, SW; He, Y; Ha, SG; Loh, HH; Wei, LN (2008) Epigenetic regulation of kappa opioid receptor gene in neuronal differentiation. Neuroscience 151: 1034-41.
99. Chen, YL; Law, PY; Loh, HH (2006) Nuclear factor kappa B signaling in opioid functions and receptor gene expression. J Neuroimmune Pharmacol 1: 270-9.
100. Bi, J; Tsai, NP; Lu, HY; Loh, HH; Wei, LN (2007) Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA. Proc Natl Acad Sci 104: 13810-5.
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