Fuming Zhang
Fuming Zhang
Research Professor
  • :518-276-6839

Department of Chemical and Biological Engineering
Rensselaer Polytechnic Institute (RPI)


1997 Ph. D. Microbiology, The University of Leeds, Leeds City, UK
1991-1993 MS courses in Biochemical Engineering, Zhejiang University
1986 B. Eng. Biochemical Engineering, HuaQiao University, China



After eight years of teaching and research in Biochemical Engineering at the Zhejiang University of Technology, I went to the University of Leeds as a Ph.D. student to study in Microbiology. I joined the Linhardt Group at University of Iowa in 1999, after I worked in Hong Kong University of Science and Technology (HKUST) for one year as a research associate. I moved to Rensselaer Polytechnic Institute (RPI) with the Linhardt Group in 2003.  I have published more than 140 research papers, several patents. I received a few scientific achievement awards (such as Research Excellent Award, RPI, 2012; the Zhejiang Provincial Government Scientific Achievement Awards, 1993).

Research Interest

His research areas are molecular interactions using surface plasmon resonance (SPR) spectroscopy and glycan analysis using NMR and LCMS in glycomics and glycobiology. 

Professional Activities:


  1. Research Excellent Award, Rensselaer Polytechnic Institute (RPI), 2012
  2. Scientific Achievement Award, Zhejiang Provincial Government, China, 1993
  3. Certification of Merit (Distinguished graduate), HuaQiao University, China, 1986



  1. F. Zhang, J. Zhang, R. J. Linhardt, Interactions between heparin/GAGs and nattokinase Glycoconjugate Journal, in press, 2015
  2. F. Zhang, K. B. Lee and R. J. Linhardt. SPR Biosensor Probing the Interactions between TIMP-3 and Heparin/GAGs. Biosensors, 5, 500-512, 2015.
  3. Z.G. Liu, C.D. Wang, J.L. Hu, F. Zhang, R.J. Linhardt, X.C. Lin, Apparent Digestibility of Diet Dominantly Comprised of Phyllostachys Vivax Bamboo Shoots for Captive Giant Pandas, Journal of Animal and Plant Sciences 25, 612-617, 2015.
  4. J. Y. Baik, H. Dahodwala, E. Oduah, L. Talman, T. R. Gemmill, L. Gasimli, P. Datta, B. Yang, G. Li, F. Zhang, L. Li, R. J. Linhardt, A. M. Campbell, S.F. Gorfien, S. T. Sharfstein. Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin.  Biotechnology Journal, 10, 1067–1081, 2015.
  5. C.P. Wang, V.C. Hascall, F. Zhang, R.J. Linhardt, A. Abbadi, A Wang, The responses of hyperglycemic dividing mesangial cells to heparin is mediated by the non-reducing terminal trisaccharide. Journal of Biological Chemistry, 2015 Sep 16. pii: jbc.M115.677401.
  6. X. Sun, L. Li, K. H. Overdier, L. A. Ammons, I. S. Douglas, C. C. Burlew, F. Zhang, E.P. Schmidt, L. Chi, R. J. Linhardt,  Analysis of total human urinary glycosaminoglycan disaccharides by liquid chromatography-tandem mass spectrometry, Analytical Chemistry, 87, 6220−6227, 2015.
  7. G. Sua, L. Lia, W. Zhong, F. Zhang, R.J. Linhardt, Production of a low molecular weight heparin using recombinant unsaturated glycuronidase, Carbohydrate Polymers, 134, 151–157, 2015.
  8. S.-J. Kwon, F. Zhang, J. S. Dordick, W. J. Sonstein, R.J.  Linhardt. Detection of cerebrospinal fluid leakage by specific measurement of transferrin glycoforms.  Electrophoresis, 36, 2425–2432, 2015.
  9. U. Bhaskar, A.M. Hickey, G. Li, C. Cai, L. Fu, Z. Ou, R. V. Mundra, F. Zhang, J. S. Dordick, R. J. Linhardt.  A purification process for heparin and precursor polysaccharides using the pH responsive behavior of chitosan. Biotechnology Progress, 31, 1348–1359, 2015.
  10. Z. Li, H. Moniz, S. Wang, A. Ramiah, F. Zhang, K. W. Moremen, R. J. Linhardt, J. S. Sharp, High structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin binding interface, Journal of Biological Chemistry, in press, 2015
  11. J. Zhang, M. Suflita,G. Li, W. Zhong, L. Li, J. S. Dordick, R. J. Linhardt, F. Zhang, High cell density cultivation of recombinant Escherichia coli strains expressing 2-O-sulfotransferase and C5-epimerase for the production of bioengineered heparin, Applied Biochemistry and Biotechnology, 175(6):2986-95, 2015
  12. Z. Liu, F. Zhang, L. Li, G. Li, W. He, R. J. Linhardt, Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs, Glycoconjugate Journal, 31, 593–602, 2014.
  13. F. Zhang, J. Xie, R. J. Linhardt, Isolation and structural characterization of glycosaminoglycans from heads of red salmon (Oncorhynchus nerka), Journal of Biotechnology and Bioengineering, 1, 1-5, 2014.
  14. L. Fu, S.A. McCallum, J. Miao, C. Hart, G. Tudryn, F. Zhang, R. J. Linhardt, Rapid and accurate determination of the lignin content of lignocellulosic biomass by solid-state NMR, Fuel, 141 39–45, 2015.
  15. J. Zhang, M. Suflita, G. Li, L. Li, F. Zhang, J.S. Dordick, R. J. Linhardt, High cell density cultivation of a recombinant Escherichia coli strain expressing a 6-O-sulfotransferase for the production of bioengineered heparin, Applied Microbiology, in press, 2014.
  16. John P. Iasper, Fuming Zhang, Russell B. Poe and Robert J. Linhardt, Stable-Isotopic Analysis of Porcine, Bovine, and Ovine Heparins, Journal of Pharmaceutical Science, in press, 2014
  17. L. Fu, L. Li, C. Cai, G. Li, F. Zhang, Robert J. Linhardt, Heparin stability by determining unsubstituted amino groups using HILIC-MS, Analytical Biochemistry, 461, 46–48, 2014
  18. F. Zhang, X. Liang,Y. Lee, and R. J. Linhardt, The effects of metal ions on heparin/heparin sulfate-protein interactions, Journal of Biomedical Technology and Research, 1, 1-7, 2014, (corresponding author)
  19. Ucakturk, Ebru; Cai, Chao; Li, Lingyun; Li, Guoyun; Zhang, Fuming; Linhardt, Robert J. Capillary electrophoresis for total glycosaminoglycan analysis. Analytical and Bioanalytical Chemistry, 406, 4617–4626, 2014.
  20. Peng Xu, Lingyun Li, Fuming. Zhang, Gregory Stephanopoulos, Mattheos Koffas, Improving fatty acids production by engineering dynamic pathway regulation and metabolic control, PNAS, 111(31):11299-304, 2014
  21. J. J. Aguilera, J. Beaudet, F. Zhang, R. J. Linhardt, W. Colón Glycosaminoglycan-modulated divergent aggregation of Serum Amyloid A. Biochimie, 104, 70-80, 2014.
  22. G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt, Analysis of 3-O-sulfo group containing heparin tetrasaccharides in heparin by liquid chromatography-mass spectrometry, Analytical Biochemistry,455, 3–9, 2014.
  23. L. Fu, F. Zhang, G.  Li, A. Onishi, U. Bhaskar, P. Sun,1 R. J. Linhardt, Structure and activity of a novel low molecular weight heparin produced by enzymatic ultrafiltration, Journal of Pharmaceutical Science, 461, 46–48, 2014.
  24. Q. Wang, C. Wang, Y. Li. F. Zhang, Xinle Liang, Genome shuffling and ribosome engineering of Streptomyces actuosus for high yield nosiheptide production, Journal of Industrial Microbiology & Biotechnology, submitted. 2014
  25. F. Zhang, H. A. Moniz, B. Walcott, K. W. Moremen, L. Wang and R. J. Linhardt, Probing the impact of GFP tagging on Robo1-heparin interaction, Glycoconjugate Journal, 31, 299–307, 2014, (corresponding author)
  26. R. G. Walker, C. Kattamuri, D. M. Luedeke, F. Zhang, R. J. Linhardt, and T. B. Thompson, Heparin and heparan sulfate alter follistatin binding to myostatin and activin A, Biochemistry, submitted.  2014.
  27. Fulcher, Yan; Sanganna Gari, Raghavendar; Frey, Nathan; Zhang, Fuming; Linhardt, Robert; King, Gavin; Van Doren, Steven, Heparin activates a tumor-secreted protease via tethering and V-type allostery, ACS Chemical Biology, 9: 957−966, 2014,
  28. P. Xu, W. Wang, L. Li, N. Bhan, F. Zhang, M. Koffas, Design and kinetic analysis of a hybrid promoter-regulator system for malonyl-CoA sensing in E. coli. ACS Chemical Biology, 9 (2):451–458, 2014.
  29. Y.Yu, F. Zhang, D. Lu, H. Zhang, Selenium bioavailability from shrimps (Penaeus vannamei Boone) and its effect on the metabolism of phospholipid and cholesterol ester, Journal of functional Foods, Volume 6: 186–195, 2014.
  30. G. Li, C. Cai, L. Li, L. Fu, Y. Chang, F. Zhang, T.  Toida, C.  Xue, R. J. Linhardt, Method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry, Analytical Chemistry, 86(1):326-30, 2014
  31. B. Zhang, W. Xiao, H. Qiu, F. Zhang, H. Moniz, A. Jaworski, E. Condac, G. Gutierrez-Sanchez, C. Heiss, R. Clugston, P. Azadi, J. J. Greer, C. Bergmann, K. Moremen, D. Y. Li, R. J. Linhardt, J. D. Esko, L. Wang, Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia., Journal of Clinical Investigation, 124(1):209-21, 2014.
  32. H. Huang,Y. Zhao,S. Lv,W. Zhong,F. Zhang,R. J. Linhardt, Quantitation of heparosan with heparinase III and spectrophotometry, Analytical Biohemistry, 447:46-8, 2014.
  33. J. M. Beaudet, L.Mansur, E. Joo, E. Kamhi, B. Yang, T. M. Clausen, A. Salanti, F. Zhang, R. J. Linhardt, Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes, Glycoconjugate Journal, 31(2):109-16, 2014.
  34. J. Xiong, U. Bhaskar,  G. Li, L. Fu, L. Li,  F. Zhang, J. S. Dordick, R. J. Linhardt, Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin, Biotechnology Journal, 167(3):241-7, 2013.
  35. L. Qiu, W. Chen, L. Zhong, W. Wu, S. Wu, J. Chen, F. Zhang, W. Zhong, Formaldehyde biodegradation by immobilized Methylobacterium sp. XJLW cells in a three-phase fluidized bed reactor, Bioprocess and Biosystems Engineering, DOI 10.1007/s00449-013-1110-4, 2013.
  36. G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, C. Xue, J. Liu, P. L. DeAngelis, R. J. Linhardt, N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation, Biopolymers, 99, 675-685, 2013.
  37. F. Zhang, H.A. Moniz, B. Walcott, K. W. Moremen, R. J. Linhardt and L.Wang, Characterization of the Interaction between Robo1 and Heparin/other Glycosaminoglycans, Biochimie, 95(12):2345-53, 2013. (corresponding author)
  38. F. Zhang, J. Aguilera, J. M. Beaudet, Q. Xie, T. F. Lerch, W. Colón, M. S. Chapman and R. J. Linhardt. Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-associated Virus, Biochemistry, 52, 6275–6285, 2013.
  39. F. Zhang,  B. Wacott, A. Wlodawer,  M.L.V. Oliva and R. J. Linhardt, Kinetic and Structural Studies on Interactions between Heparin/GAGs and a Crataeva tapia Bark Protein Using Surface Plasmon Resonance, Biochemistry, 52, 2148−2156, 2013
  40. F. Zhang, L. Fu, G. Li, B. Yang, A. Onishi, L. Li and R. J. Linhardt, Structural characterization of heparins from different animal sources, Journal of Pharmaceutical Science, 102(5):1447-57, 2013
  41. W. Wang, P. Xu, J. Dordick, F. Zhang, Q. Yuan, M. Koffas, R.J. Linhardt, Expression of low endotoxin 3-O-sulfotransferase in Bacillus subtilis, Applied Biochemistry and Biotechnology, 171, 954–962, 2013.
  42. K. Nolan, C. Kattamuri, D. M. Luedeke, A. Deng, A. Jagpal, F. Zhang, R. J. Linhardt, A. P. Kenny, A. M. Zorn, T. B. Thompson, Structure of Protein Related to DAN and Cerberus (PRDC): Insights into the Mechanism of BMP Antagonism, Structure, 21, 1417–1429, 2013.
  43. A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Microanalysis of stomach cancer glycosaminoglycans, Glycoconjugate Journal, 30, 701–707, 2013
  44. X. Zhao, B. Yang, L. Li, F. Zhang, R. J. Linhardt, On-line separation and characterization of hyaluronan oligosaccharides derived from radical depolymerization, Carbohydrate Polymers, 96, 503– 509, 2013.
  45. C. Wang, G. Wu, Y. Li, Y. Huang, F. Zhang, X. Liang, Genome Shuffling of Penicillium citrinum for Enhanced Production of Nuclease P1.  Appl Biochem Biotechnol. (2013) 170:1533–1545
  46. L. Wang, H. Zhang, L. Yang, X. Liang, F. Zhang, R. J Linhardt, Structural characterization and bioactivity of exopolysaccharide synthesized by Geobacillus sp. TS3-9 isolated from radioactive radon hot spring, Appl Biochem Biotechnol., 2013, in press.
  47. J. J. Ziarek, C. T. Veldkamp, F. Zhang, N. J. Murray, G. A. Kartz, X. Liang, J. Su, J. E. Baker1, R. J. Linhardt, and B. F. Volkman, Heparin oligosaccharides inhibit chemokine (C-X-C motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (C-X-C motif) receptor 4 (CXCR4) amino-terminus, Journal of Biological Chemistry, 288(1):737-46, 2013.
  48. A. Weyers, B.Yang, K. Solakyildirim, V.Yee, F. Zhang, R. Linhardt, Extraction and Protein Binding Interactions of Keratan Sulfate from Bovine Cornea, FEBS Journal, 280: 2285–2293     , 2013.
  49. X. Zhao, B. Yang, K. Linkens, P. Datta, A. Onishi, F. Zhang, R. J. Linhardt, Microscale separation of heparosan, heparan sulfate and heparin, Analytical Biochemistry, 434(2):215-7, 2013.
  50. L. Li, F. Zhang, J. Zaia, R. J. Linhardt, Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS, Analytical Chemistry, 84, 8822−8829, 2012.
  51. S. Kwon, K. Lee, K. Solakyildirim, S. Masuko, M. Ly, F. Zhang, L. Li, J. S. Dordick, R. J. Linhardt, Ultrasensitive carbohydrate detection by Glyco-qPCR amplification and applications in glycobiology, Angewandte Chemie, 51(47):11800-4, 2012
  52. F. Zhang, J. M. Beaudet,  D. M. Luedeke, R. G. Walker, T. B Thompson and R. J. Linhardt, Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using Surface Plasmon Resonance, Biochemistry, 51(34):6797-803, 2012.
  53. J. Miao, F. Zhang, T. Majde, S. Mousa, R. J. Linhardt, Study of adsorption of doxorubicin using PMMA-chitosan-heparin coated Ukraine activated carbon beads, Langmuir, 28:4396-403, 2012.
  54. X. Zhao,B.Yang, P. Datta, L. Gasmili, F. Zhang and  R. J. Linhardt, Cell-Based Microscale Isolation of Glycoaminoglycans for Glycomics Study, Journal of Carbohydrate Chemistry, Vol. 31 (4-6): 420-435, 2012.
  55. J. Baik, L. Gasimli, B. Yang, P. Datta, F. Zhang, C. A. Glass, J. D. Esko, R. J. Linhardt, S.T. Sharfstein, Metabolic Engineering of CHO to make haparan sulfate. Metabolic Engineering, 14, 81–90, 2012.
  56. Bhaskar, E. Sterner, A. M. Hickey, A. Onishi, F. Zhang, J. S. Dordick, R.J. Linhardt, Engineering of routes to heparin and related polysaccharides, Applied Microbiology and Biotechnology, 93:1–16, 2012
  57. Z. Wang, F. Zhang, J. S. Dordick, R. J. Linhardt, Molecular weight characterization for glycosaminoglycans with different degrees of sulfation by size exclusion chromatography, Current Analytical Chemistry, in press, 2012.
  58. F. Zhang, X. Liang, D. Pu, S. Walsh and R. J. Linhardt, Biophysical Characterization of Glycosaminoglycan-IL-7 Interactions using SPR. Biochimie 94,  242-249, 2012. (corresponding author)
  59. A.Weyers, B. Yang, D.Yoon, J. Park, K. Lee, F. Zhang, and R. J. Linhardt. Structural Analysis of Glycosaminoglycans from Lethal and Non-Lethal Breast Cancer Tissues, Omics, 16, 79-90, 2012.
  60. C. Cai,   K. Solakyildirim, B. Yang, J.M. Beaudet, A. Weyer, R. J. Linhardt and F. Zhang. Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A. Carbohydrate Polymers 87, 822– 829, 2012. (corresponding author)
  61. W. Zhao, F. Zhang, R. J. Linhardt, Optimal sequence size for heparin binding to vascular endothelial growth factor (VEGF165), Bioscience Report, 32, 71–81, 2012
  62. F. Zhang, B.Yang, M. Ly, K. Solakyildirim, Z. Xiao, Z. Wang, Y. Chang, J. S. Dordick and R.J. Linhardt. Chemical structure characterization of commercial heparin from different commercial sources, Analytical and Bioanalytical Chemistry, 401, 2793-2803, 2011. (corresponding author)
  63. Wang Z, Li J, Cheong S, Bhaskar U, Akihiro O, Zhang F, Dordick JS, Linhardt RJ. Response surface optimization of the heparosan N-deacetylation for producing bioengineered heparin. J Biotechnol. 156, 188– 196, 2011.
  64. Masuko S, Higashi K, Wang Z, Bhaskar U, Hickey AM, Zhang F, Toida T, Dordick JS, Linhardt RJ. Ozonolysis of the double bond of the unsaturated uronate residue in low-molecular-weight heparin and K5 heparosan. Carbohydr Res. 27;346(13):1962-6, 2011
  65. H.G.Garg, H. Mrabat1, L. Yu, C.A. Hales, B. Li, C.N. Moore, F. Zhang and R. J. Linhardt. Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells. Glycoconjugate Journal, 28(6):419-26, 2011
  66. Higashi K, Ly M, Wang Z, Masuko S, Bhaskar U, Sterner E, Zhang F, Toida T, Dordick JS, Linhardt RJ.Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered Heparin Precursor. Carbohydr Polym. 1;86(3):1365-1370, 2011
  67. B. Yang, A.Weyers, J. Baik, E. Sterner, S. Sharfstein, S. A. Mousa, F. Zhang, J. S. Dordick, R. J. Linhardt, Ultraperformance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis, Anal Biochem. Aug 1;415(1):59-66, 2011.
  68. J. Beaudet,  A. Weyers, K. Solakyildirim, B. Yang, S. Mousa, F. Zhang and R. J. Linhardt, The Effect of Autoclave on the Activity of Pharmaceutical Heparin, Journal of Pharmaceutical Science, 2011, Journal of Pharmaceutical Sciences. 100, 3396–3404, 2011 (corresponding author)
  69. G. Anand, F, Zhang, R. J. Linhardt, G. Belfort, Protein-associated water effects the removal of blood proteins from metallic substrates, Langmuir, Mar 1;27(5):1830-6, 2011
  70. W.  Zhong, Y. Li, K. Sun, F. Zhang, J. Jing, J. Chen, Aerobic degradation of methyl tert-butyl ether in a symbiosis system with mixed culture of Chlorella ellipsoidea and Methylibium petroleiphilum PM1, Journal of Hazard Materials. 185, 1249-1255, 2011.
  71. Z. Liu, Z. Xiao, S. Masuko, W. Zhao E. Sterner, F. Zhang and R. J. Linhardt, Mass Balance Analysis of Contaminated Heparin Product, Analytical Biochemistry, 408, 147–156, 2011. (corresponding author)
  72. W. Zhong, B.Wu, W. Wang, L. Zhong, Y. Li, F. Zhang, Coenzyme Q10 production by Sphingomonas sp. ZUTE03 with transformation-extraction coupled process, Appl. Microbiol. Biotechnol. 89(2):293-30, 2011.
  73. M. Ly, Z. Wang, T. N. Laremore, F. Zhang, W. Zhong, D. Pu, D. V. Zagorevski, J. S. Dordick, R. J. Linhardt, Analysis of E. coli K5 capsular polysaccharide heparosan,  Analytical and Bioanalytical Chemistry, Jan;399(2):737-45, 2011.
  74. Z. Liu, S. Masuko,  K. Solakyildirim, D. Pu , F. Zhang, R. J. Linhardt, Glycosaminoglycans of the porcine central nervous system,  Biochemistry, Vol. 49, No. 45, 2010. (corresponding author)
  75. H.G. Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Effect of Carboxyl-Reduced Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells, Carbohydrate Research, 345, 1084–1087, 2010
  76. Z. Wang, M. Ly,  F. Zhang, W. Zhong, A. Suen, J. S. Dordick, R. J. Linhardt, E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor, Biotechnology and Bioengineering, Vol. 107, No. 6, 2010.
  77. T. N. Laremore, F. Zhang, J. S. Dordick, J. Liu, R. J. Linhardt, Recent progress and applications in glycosaminoglycan and heparin research, Current Opinions in Chemical Biology, 13:1-8, 2009.
  78. H. Ra, S. Harju-Baker, F. Zhang, Robert J. Lindardt, C. L. Wilson, W. C. Parks. Activation of promatrilysin (mmp7) and control of substrate-specific activity by sulfated glycosaminoglycans. Journal of Biological Chemistry, 284: 27924–27932, 2009.
  79. J. Han, F. Zhang, J. Xie, R. J. Linhardt and L. M. Hiebert, Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin," Cardiovascular Diabetology, 8, 46-58, 2009.
  80. F. Zhang, Z. Zhang, X. Lin, A. Beenken, M. Mohammadi and R. J. Linhardt. Structural analysis on heparin/heparan sulfate interacting with FGF•FGFR complexes, Biochemistry, 48, 8379–8386, 2009. (corresponding author)
  81. J. Suwan, Z. Zhang, B. Li, P. Vongchan, P. Meepowpan, F. Zhang, S.A. Mousa, S. Mousa, B. Premanode, P. Kongtawelert, R. J. Linhardt, Sulfonation of papain treated chitosan and its mechanism for anticoagulant activity, Carbohydrate Research, 344: 1190–1196, 2009.
  82. B. Li, J.Suwan, J.G. Martin, F. Zhang, Z. Zhang, D. Hoppensteadt, M. Clark, J. Fareed, R.J. Linhardt, Oversulfated chondroitin sulfate interaction with heparin-binding proteins:  New insights into adverse reactions from contaminated heparins, Biochemical Pharmacology, 78: 292–300, 2009.
  83. I. G. Sava, F. Zhang, I. Toma, C. Theilacker, B. Li, T. F. Baumert, O. Holst, R. J. Linhardt, J. Huebner, Novel Interactions of Glycosaminoglycans and Bacterial Glycolipids Mediate Binding of Enterococci to Human Cells, Journal of Biological Chemistry,  284: 18194–18201, 2009.
  84. Z. Zhang, B. Li, J. Suwan, F. Zhang, Z. Wang, H. Liu, B. Mulloy, R. J. Linhardt, Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE, Journal of Pharmaceutical Science, 98, 4017-4026, 2009.
  85. F. Zhang, Z. Zhang, R. Thistle, L. McKeen, S. Hosoyama, T. Toida, R. J. Linhardt, P. Page-McCaw, Structural Characterization of Glycosaminoglycans from Zebrafish in Different Ages, Glycoconjugate Journal, 26:211–218, 2009.
  86. H. G.Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Significance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the   Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells,  Carbohydrate Research, 343, 2406−2410, 2008.
  87. S. Bhattacharyya, R. Gill, M. Chen, F. Zhang, R. J. Linhardt, P. K. Dudeja, J. K. Tobacman, Toll-like Receptor 4 Mediates Induction of Inflammatory Pathway by Food Additive Carrageenan, Journal of Biological Chemistry  283, 10550-10558, 2008.
  88. M. Warda, F. Zhang, M. Radwan, Z. Zhang, R. J. Linhardt, H. Jin, Is Human Placenta Proteoglycan Remodeling Involved in Pre-Eclampsia? Glycoconjugate Journal, 25, 441–450, 2008.
  89. R. Copeland, A. Balasubramaniam, V. Tiwari, F. Zhang, A. Bridges, R. J. Linhardt, D. Shukla, J. Liu, Using a 3-O-Sulfated Heparan Sulfate Octasaccharide to Inhibit the Entry of Herpes Simplex Virus 1, Biochemistry, 47, 5774–5783, 2008.
  90. J. Nam, F. Zhang, M. Ermonval, R. J. Linhardt and S. T. Sharfstein, The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells. Biotechnology and Bioengineering, 100, 1178-1192, 2008.
  91. Z. Zhang, J. Xie, F.  Zhang and R. J. Linhardt, Thin Layer Chromatography for the Analysis of Glycosaminoglycan Oligosaccharides. Analytical Biochemistry, 371, 118-120, 2007.
  92. S. A. Mousa, F. Zhang, A. Aljada, S. Chaturvedi, M. Takieddin, H. Zhang, L. Chi, E. Arbit, M. C. Castelli, M.M. Goldberg, R. J. Linhardt, Pharmacokinetic and Pharmacodynamic of Oral Heparin Solid Dosage Form in Healthy Human Subjects.  Clinical Pharmacology, 47, 1508-1520, 2007.
  93. F. Zhang, J. S. McLellan, A. M. A. Jiménez, D. J. Leahy, R. J. Linhardt, Kinetic and Structural Studies on Interactions between Heparin/Heparan Sulfate and Proteins of the Hedgehog Signaling Pathway, Biochemistry, 46, 3933-3941, 2007. (corresponding author and Hot Article of the Month)
  94. R. Goetz, A. Beenken, O. A. Ibrahimi1, J. Kalinina1, S. K. Olsen1, A. V. Eliseenkova, C. F. Xu, T. Neubert, F. Zhang, R. J. Linhardt, X. Yu, K. E. White, T. Inagaki, S. A. Kliewer, M. Yamamoto, H. Kurosu, Y. Ogawa, M. Kuro-o, B. Lanske, M. S. Razzaque, M. Mohammadi, Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members, Molecular and Cellular Biology, 27, 3417-3428, 2007.
  95. Shaker A. Mousa, Haifeng Zhang, Ahmad Aljada, Fuming Zhang, Ehud Arbit, Lewis Bender, Michael Goldberg, and Robert Linhardt. Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects. Blood, 110: 4009, 2007.
  96. T.N. Laremore, F. Zhang, R. J. Linhardt, New Ionic Liquid Matrix for Direct UV-MALDI-TOF-MS Analysis of Dermatan Sulfate and Chondroitin Sulfate Oligosaccharides, Analytical Chemistry, 79, 1604-1610, 2007.
  97. C. Shao, F. Zhang, R. J. Linhardt, J. F. Head, B. Seaton, Crystallographic Analysis of Calcium-Dependent Heparin Binding to Annexin A2, Journal of Biological Chemistry, 281, 31689–31695, 2006.
  98. H. Barth, E. K. Schnober, F. Zhang, R. J. Linhardt, E. Depla, B. Boson, F.-L. Cosset, A. Patel, H. E. Blum, T. F. Baumert, Viral and Cellular Determinants of Hepatitis C Virus Envelope-Heparan Sulfate Interaction, Journal of Virology, 80, 10579-10590, 2006.
  99. M. Warda, T. Toida, F. Zhang, P. Sun, E. Munoz, R. J. Linhardt,  Isolation and Characterization of Heparan Sulfate from Various Murine Tissues, Glycoconjugate Journal, 23, 553-561, 2006.
  100. E. Munoz, D. Xu, M. Kemp, F.  Zhang, J.  Liu, R. J.   Linhardt, Affinity, Kinetic, and Structural Study of the Interaction of 3-O-Sulfotransferase Isoform 1 with Heparan Sulfate, Biochemistry, 45, 5122-5128, 2006.
  101. B. Daniels, R.J. Linhardt, F. Zhang, W. Mao, S. Wice, L. Hiebert, In Vivo Antithrombotic Synergy of Oral Heparin and Arginine: Endothelial Thromboresistance Without Systemic Anticoagulation, Thrombosis and Haemostasis, 95, 865-72, 2006.
  102. F. Zhang, P. Sun, E. Muñoz, L.Chi, S. Sakai, T. Toida, R. J. Linhardt, Microscale Isolation and Analysis of Heparin from Plasma using an Anion Exchange Spin Column, Analytical Biochemistry, 353, 284-286, 2006.
  103. J. Y. Suk, F. Zhang, W. E. Balch, R. J. Linhardt, J. W. Kelly, Heparin Accelerates Gelsolin Amyloidogenesis, Biochemistry, 45, 2234-2242, 2006.
  104. Yu X, Ibrahimi OA, Goetz R, Zhang F, Davis SI, Garringer HJ, Linhardt RJ, Ornitz DM, Mohammadi M, White KE, Analysis of the biochemical mechanisms for the endocrine actions of FGF23., Journal of Bone and Mineral Research 20 (9): S27, Suppl. 1, 2005.
  105. S. K. Olsen, J.Y.H. Li, C. Bromleigh, A.V. Eliseenkova, O. A. Ibrahimi, Z. Lao, F. Zhang, R. J. Linhardt, A. L. Joyner and M. Mohammadi, Structural Basis by Which Alternative Slicing Modulates the Biological Activity of FGF8, Genes and Development, 20, 185-198, 2006.
  106. X. Yu, O. A. Ibrahimi, F. Zhang, S. I. Davis, H. J. Garringer, R. J. Linhardt, D. M. Ornitz, M. Mohammadi, and K. E. White.  Analysis of the Biochemical Mechanisms for the Endocrine Actions of FGF23.  Endocrinology. 146, 4647-56, 2005.
  107. O.A. Ibrahimi, B.K. Yeh, A.V. Eliseenkova, F. Zhang, S.K. Olsen, M. Igarashi, S.A. Aaronson, R.J. Linhardt, M. Mohammadi, Analysis of Mutations in FGF and a Pathogenic Mutation in FGFR Provide Direct Evidence in Support of the Two-End Model for FGFR Dimerization. Molecular & Cellular Biology, 25, 671-684, 2005.
  108. Omar A. Ibrahimi, Fuming Zhang, Anna V. Eliseenkova, Nobuyuki Itoh, Robert J. Linhardt, and Moosa Mohammadi.  Biochemical Analysis of Pathogenic Ligand-dependent FGFR2 Mutations Suggests Distinct Pathophysiological Mechanisms for Craniofacial and Limb Abnormalities in Human Skeletal Disorders. Human Molecular Genetics, 13, 2313 – 2324, 2004.
  109. F. Zhang, A. D. Bries, S.C. Lang, Q. Wang, J.M. Weiler, R.J. Linhardt, Metabolic Alteration of the N-Glycan Structure of a Protein from Patients with a Heterozygous Protein Deficiency.  Biochimica Biophysica Acta, 1739, 43-49, 2004.
  110. F. Zhang, Y. Wu, Q. Ma, D. Hoppensteadt, J. Fareed, R. J. Linhardt, Studies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance. Clinical and Applied Thrombosis/Hemostasis, 10, 249-257, 2004.
  111. O. A. Ibrahimi, F. Zhang, S. C. Lang Hrstka, M. Mohammadi, R. J. Linhardt, A Kinetic Model for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly, Biochemistry, 43, 4724-4730, 2004.
  112. F. Zhang, F. Ronca, R.J. Linhardt, R.U. Margolis, Structural Determinants of Heparan Sulfate Interactions With Slit Proteins.  Biochemical Biophysical Research Communications, 317, 352-357, 2004.
  113. F. C. Peterson, E. S. Elgin, T. J. Nelson, F. Zhang, T. J. Hoeger, R. J. Linhardt, B. F. Volkman, A Glycosaminoglycan Recognition Element of Lymphotactin Essential for In Vivo Chemokine Activity.  Journal of Biological Chemistry, 279, 12598-12604, 2004.
  114. S. K. Olsen, O. A. Ibrahimi, A. Raucci, F. Zhang, A. V. Eliseenkova, A. Yayon, C. Basilico, R. J. Linhardt, J. Schlessinger, M. Mohammadi, Insights Into the Molecular Basis for FGF Receptor Autoinhibition and Ligand binding Promiscuity.  Proceedings of the National Academy of Sciences USA, 101, 935-940, 2004.
  115. O.A. Ibrahimi, F. Zhang, A. V. Eliseenkova, R. J. Linhardt, M. Mohammadi, Proline to Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis Syndromes Through the Enhancement of FGF Binding Affinity.  Human Molecular Genetics, 13, 69-78, 2004.
  116. H. Barth, C. Schäfer, M.I. Adah, F. Zhang, R.J. Linhardt, H. Toyoda, A. Kinoshita-Toyoda, T. Toida, T. H. van Kuppevelt, E. Depla, F. von Weizsäcker, H.E. Blum, T.F. Baumert, Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate.  Journal of Biological Chemistry, 278, 41003 – 41012, 2003.
  117. F. Zhang, A. M. Fath, R. Marks and R. J.  Linhardt, A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interaction Studies. Analytical Biochemistry. 304, 271-273, 2002.
  118. F. Zhang, D. W. Murhammer and R. J.  Linhardt, Kinetic and Glycan Structure Characterization of Secreted Alkaline Phosphatase from the Baculovirus Expression Vector System. Applied Biochemistry and Biotechnology, 101, 197-210, 2002.
  119. F. Zhang, M. A. Saarinen, D. W. Murhammer and R. J. Linhardt, The Effect of Dissolved Oxygen (DO) Concentration on the Glycosylation of Recombinant Protein Produced by the Insect Cell-Baculovirus Expression System. Biotechnology and Bioengineering, 77, 219-224, 2002.
  120. W.M. Wolff, F. Zhang, D. W. Murhammer, R. J. Linhardt and J. M. Weiler, Expression of C1 Esterase Inhibitor by the Baculovirus Expression Vector System: Preparation, Purification and Characterization. Protein Expression and Purification. 22, 414-421, 2001.
  121. F. Zhang, Wolff  W. M., Murhammer D. W. and Linhardt  R. J.  Affinity Purification of Secreted Alkaline Phosphatase Produced by the Baculovirus Expression Vector System.  Applied Biochemistry and Biotechnology, 90, 125-136, 2001.
  122. J. S. Knapp, E. J. Vantoch-Wood, and F. Zhang, Use of Wood-Rotting Fungi for the Decolourisation of Dyes and Industrial Effluents. Editor: Gadd, G. M. Fungi in Bioremediation. Cambridge University Press. 2001,
  123. J. Choe, F. Zhang, W. M. Wolff, R. J. Linhardt and J. S. Dordick, Separation of AGP Glycoforms Using Affinity-Based Reverse Micellar Extraction and Separation. Biotechnology and Bioengineering, 70, 484-490, 2000.
  124. F. Zhang and J. Yu, Decolourisation of Acid Violet 7 with Complex pellets of White Rot Fungus and Activated Carbon. Bioprocess Engineering, 23, 295-301, 2000.
  125. F. Zhang, J. S. Knapp and K. N Tapley, Development of Bioreactor Systems for Decolourisation of Orange II Using Wood Rotting Fungus. Enzyme and Microbial Technology, 24, 48-53, 1999.
  126. F. Zhang, J. S. Knapp and K. N. Tapley, The Treatment of Cotton Bleaching Effluent with Wood Rotting fungus. Water Research, 33, 919-928, 1999.
  127. F. Zhang, J. S. Knapp and K. N. Tapley, Development of Bioreactor Systems for Decolourisation of Cotton Bleaching Effluent by Wood Rotting Fungus. Biotechnology Letters, 20, 717-723, 1998.
  128. F. Zhang, The Treatment of Coloured Effluents with Wood Rotting Fungi. PhD thesis. The University of Leeds, 1997.
  129. J. S. Knapp, F. Zhang and K. N. Tapley,  Decolourisation of Orange II by a Wood Rotting Fungus. Journal of Chemical Technology and Biotechnology, 69, 289-296, 1997.
  130. B. Yu, F.Zhang, P. Wang and Y. Zhen, Alcohol Fermentation from the Mash of Dried Sweet Potato with Its Dregs Using Immobilized Yeast. Process Biochemistry, 31, 1-6, 1996.
  131. B. Yu, F. Zhang and P. Wang, Study on the Production of L-Malic Acid by Bioconversion: Screening of Fumarase Producing Strains. Food and Fermentation Industries (Ch), 1, 18-23, 1996.
  132. B. Yu, F.Zhang, P. Wang and Y. Zhen, Alcohol Fermentation Using Thin-slice Packed Bed Bioreactor by Immobilized Yeast Cells. Industrial Microbiology (Ch), 3, 24-28, 1995.
  133. B. Yu, F.Zhang, P. Wang and Y. Zhen, Scale-up Research on Alcoholic Fermentation from Dried Sweet Potato by Immobilized Yeast. Food and Fermentation Industries (Ch), 2, 1-6, 1994.
  134. B. Yu, F.Zhang, Production of Ethanol by Fermentation of Dried Sweet Potato with Immobilized Yeast Cells. Chinese Journal of Biotechnology, 9, 1, 24-29, 1993.
  135. B. Yu, F.Zhang, Studies on Inhibitory Factors in Lactic Acid Fermentation. Journal of Zhejiang University of Technology (Ch), 1, 58-64, 1992.
  136. B. Yu, F.Zhang, P. Wang, Study on Production of Ethanol by Fermentation of the Mash of Dried Sweet Potato Using Immobilized Yeast Cells. Food and Fermentation Industries (Ch), 4, 1-7, 1991.
  137. B. Yu, F.Zhang, and P. Wang, Study on Latic Acid Fermentation Using Immobilized Cells. Journal of Zhejiang University of Technology (Ch), 3, 9-15, 1991.
  138. B. Yu, F.Zhang, P. Wang, Screening and Mutagenic Treatment of D-isoascorbic Acid Producing Strains. Journal of Zhejiang University of Technology (Ch), 1, 1-7, 1991.
  139. B. Yu, F.Zhang, Production of D-isoascorbic Acid (iso-vitamin C) and Its Application in Food Processes. Hangzhou Food Science (Ch), 1, 1-4, 1991.
  140. B. Yu, F.Zhang, Study on Strains, Carriers and Multiplication Processes Used in Ethanolic Fermentation of Dried Sweet Potato by Immobilized Yeast Cells. Journal of Zhejiang University of Technology (Ch), 1, 31-39, 1991.
  141. B. Yu, F.Zhang, Production of Ethanol by Fermentation of Dried Sweet Potato with Low Temperature Cooking Process and Immobilized Yeast Cells. Journal of Zhejiang University of Technology (Ch), 1, 24-29, 1990


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