Organic and analytical chemistry
Nuclear sciences for health
Ph-D in organic and medicinal chemistry at the University of Toulouse (France)in 2010
Damien Cressier is graduated from the National Graduate School of Chemistry of Montpellier (ENSCM, France) and specialized in organic chemistry. He additional hold a MSc in Biomolecular Engineering from the University of Montpellier in 2007. Funded by the French Armament Procurement Agency (DGA),.With a deep knowledge and hands-on experience in characterization of small molecules according to conventional methods,he focused his career on the challenge of the radiochemistry and radiobiology in 2010,joining the “Imaging and Therapeutical Strategies in Cerebral and Tumoral pathologies (ISTCT)” team in Cyceron (University of Caen and CNRS, Caen, France).
Damien Cressier has performed his research projects at the interface between nuclear sciences, engineering, chemistry, radiochemistry and biology.
As an organic chemist, he is skilled in multi-step synthesisof small molecules(heterocycles, nucleosides…) and in fluorine, organosulfur, organometallic (germanium, silicium) and complexationchemistry. Throughout his professional experiences, he developed deep knowledge in the characterization of novel molecules by NMR, MS, MS/MS, UV, IR...
His research themes in the field of the nuclear sciences included the development of methods to separate and purify radionuclides by SPE (mineral oxide sorbent, normal and inverse phase, ion exchange) and to check their purity (γ spectrometry, ICP-MS). Moreover, he developed and validated automated processes for radiotracer (18F, 68Ga, 11C…) production and implemented advanced analytical applications such as HPLC, radio-HPLC and LC/MS methods for qualitative and quantitative analysis of radiopharmaceuticals.
His research experiences in medicinal chemistry were performed in the context of neurodegenerative diseases and early detection of primary tumor and metastases. Damien is involved in in vitro and in vivo biological evaluations of the productsincluding determination of antioxidant properties of molecules, chemical protection of DNA against ROS, stability and biodistribution of drugs,radiometabolism studies, imaging techniques(autoradiography and fluorescence staining, µPET)
Project management of gallium-68 subpart (chemistry and biology)o Coordination between drug production and biological testing
1.Biological data management and interpretation
Module installing, setting-up and programming
Development, optimization and routine radiolabeling of [68Ga]-PIB derivatives (Eckert et Ziegler, Modular Lab)
in vitro (mice and human brain tissues: autoradiography and fluorescence staining)
in vivo (Siemens Inveon, µPET and Scanner)
- D. Cressier, L. Barré. Development of 9-β-D-arabinofuranosyladenine derivatives for a theragnostic approach of non-Hodgkin lymphomas. In preparation.
- -D. Cressier, M. Dhilly, T. T. Cao Pham, et al. Gallium-68 complexes conjugated to Pittsburgh compound B: radiolabeling and biological evaluation. Mol. Imaging Biol., 2015, in press.
- -D. Cressier, S. Oelsner, G. Hunter, et al. Smoothened titania particles to improve radionuclide separation and their application to the development of a novel [68Ge]/[68Ga] generator. RSC
- Adv., 2015, 5, 29319-29324.
- -B. Nadal, S. A-L Thetiot-Laurent, S. Pin, et al. Synthesis and antioxidant properties of pulvinic acids analogues. Bioorg Med Chem., 2010, 18, 7931-7939.
- -D. Cressier, C. Prouillac, P. Hernandez, et al. Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles. Bioorg Med Chem., 2009, 17,5275-5284.
- D. Cressier, T. Negreanu-Pirjol, C. Amourette, et al. Synthesis of new organometallic compounds and their radioprotective activity evaluation. Analele Universitatii "Ovidius" Constanta, Seria: Chimie, 2009, 20, 2.
- D. Cressier. Synthèse et évaluation de nouveaux dérivés organiques et organométalliques contre les effets des rayonnements ionisants. Laboratoire d’Hétérochimie Fondamentale etAppliquée, UMR 5069, supervision: G. Rima, Oct. 13, 2010, Toulouse.
- -D. Cressier, T. T. Cao Pham, A. F. Martins, et al. Radiolabelling and evaluation of [68Ga]- PIB derivatives for Alzheimer’s disease diagnosis. NUCSAN, Feb. 12-14, 2014, Nantes.
- -D. Cressier, P. Hernandez, G. Rima, et al. Synthèse et étude de nouveaux dérivés pour la radioprotection chimique. 9ème Colloque de Radiobiologie Fondamentale et Appliquée, Sept.22, 2009, Sévrier.
- D. Cressier, P. Hernandez, G. Rima, et al. Synthèse et étude de l’activité radioprotectrice in vitro et in vivo de nouveaux dérivés de benzothiazoles et de thiadiazoles. Société Chimique de France, Apr. 10, 2008, Toulouse.