- : 020 7882 2939
Centre for Digestive Diseases
University of London
|INSTITUTION AND LOCATION||
FIELD OF STUDY
Shouzhou Medical University, China
Shanghai Cancer Institute, China
|Karolinska Institute, Sweden||Ph.D||1992||Immunology|
Regulation of antigen processing and presentation
The development of nano-vaccine for the treatment of chronic infectious diseases regulation of balanced adaptive immune responses and immune tolerance.
1. Quality control of MHC I antigen presentation: The assembly of MHC I and antigenic peptides is regulated by different molecules in the endoplasmic reticulum (ER) of antigen presenting cells. Previous findings indicated that tapasin (TAP-A) has unique function in regulation of MHC I – peptide assembly. We are currently looking into the potential function of tapasin in selection of peptide repertoires for MHC I assembly.
2. Nano-vaccine: Based on our studies in antigen presentation in the ER membrane, we have developed a nano-vaccine delivery system by using MHC – antigen and cytokine engineered ER membrane particles. We found that the delivery of both antigen and mitogenic cytokines directly to antigen specific T cells from HBV chronically infected patients can effectively recall their anti-viral immune responses. We are currently developing HBV therapeutic vaccine for clinical trials.
3. Intrinsic regulation of B and T cell function: B and T cells are major effector lymphocytes in response to pathogen invasion. However, dysregulation of B and T cells can result in inflammatory autoimmunity or immune tolerance to pathogens. In addition to the Treg cells, B and T cells are intrinsically regulated in response to antigen and microenvironments. We are studying the mechanisms of these regulations.
4. Role of early growth response genes (Egr) in the development and function of B and T cells. Egr molecules have been found to control the development and function of B and T cells. We have developed transgenic and knockout models and demonstrated their functions in the control of immune responses and inflammatory autoimmune diseases. We are investigating the molecular mechanisms of Egr function.
All these research topics have implications in autoimmune diseases, microbial and tumor immunity as well as vaccine development.
1992-94: Postdoctoral fellow, Ludwig Institute for Cancer Research, Stockholm
1994-1996: Principal Investigator, Ludwig Institute for Cancer Research, Stockholm
1996-1998: Project Director, anti-inflammation leads, Pharmacia & Upjohon, Lund, Sweden and assistant professor, Lund University, Sweden
1998-2001 Associate Director of Molecular Biology, R & D, Astrazenica Lund and associate professor, Lund University, Sweden
2000-present: Reader, then Professor of experimental immunology, Institute of Cell and Molecular Science, Barts and the Royal London School of Medicine, QM, University of London, London.
- Suling Li, Hans-Olov Sjögren, Ulf Hellman, Ralf Pettersson and Ping Wang. Cloninig and functional characterization of a novel subunit of the transportor associated with antigen presentation. Proc.Natl. Acad. Sci., 1997, 94;8708-8713.
- Suling Li, Kajsa Paulsson, Hans-Olov Sjögren,and Ping Wang. Peptide-bound MHC class I molecules associate with tapasin before dissociation from TAP. J. Bio. Chem, 274: 8649-8654, 1999.
- Suling Li, Kajsa M. Paulsson, Shangwu Chen, Hans-Olov Sjögren, and Ping Wang. Tapasin is required for efficient peptide-binding to transporter associated with antigen processing (TAP). J. Bio. Chem. 275: 1581-1586, 2000.
- Suling Li, Shangwu Chen, Xiufeng Xu, Anette Sundstedt, Kajsa M. Paulsson, Stefan Karlsson, Hans-Olov Sjögren, and Ping Wang. Cytokine-induced SH2 protein-1 (CIS1) promotes T cell receptor mediated proliferation and prolongs survival of activated T cells. J. Exp. Med. 191:985, 2000.
- Kajsa. M. Paulsson, Per Anderson, Shangwu Chen, Hans-Olov Sjögren, Suling Li and Ping Wang. Tapasin associates with COPI-coated vesicles and directs the transport of assembled MHC class I to trans-Golgi network. J. Biol. Chem. 2002;277:18266-71.
- Per Anderson, Anette Sundstedt, Emma Massey, Suling Li, David Wraith, and Ping Wang. IL-2 overcomes the unresponsiveness, but fails to reverse the regulatory function of antigen-induced Treg cells. Journal of Immunology 2005 Jan 1;174(1):310-9..
- Anderson PO, Manzo BA, Sundstedt A, Minaee S, Symonds A, Khalid S, Rodriguez-Cabezas ME, Nicolson K, Li S, Wraith DC, Wang P. Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance. Eur J Immunol. 2006 Jun;36(6):1374-85.
- Li Li, Gronning LM., Anderson P., Li S., Edvardsen K., Johnston J., Kioussis D., Shepherd PR and Wang P. SOCS-6 inhibits negative signal of p85 regulatory subunit of phosphoinositide 3-kinase. 2004 Journal of Biological Chemistry
- Paulsson KM, Jevon M, Wang JW, Li S, Wang P. The double lysine motif of tapasin is a retrieval signal for retention of unstable MHC class I molecules in the endoplasmic reticulum. J Immunol. 2006 Jun 15;176(12):7482-8.
- Zhu B, Symonds AL, Martin JE, Kioussis D, Wraith DC, Li S, Wang P. Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med. 2008 Sep 29;205(10):2295-307.
- Sofra V, Mansour S, Liu M, Gao B, Primpidou E, Wang P, Li S. Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. Eur J Immunol. 2009 Jan;39(1):85-95.
- Mengya Liu, Tizong Miao, Haoxiang Zhu, Alistair L. J. Symonds, Li Li, Anna Schurich, Mala K. Maini, Jiming Zhang, Patrick Kennedy, Suling Li and Ping Wang. IL-2 engineered nanoAPC effectively activate viral-antigen mediated T cell responses from chronic HBV infected patients, J. Immunology, Volume 188, Number 3, 2012. (co-correspondence author, Impact fact: 5.7)
- Suling Li, Tizong Miao, Meera Sebastian, Punamdip Bhullar, Emma Ghaffari, Mengya Liu, Alistair L. J. Symonds, and Ping Wang, Egr-2 and -3 are essential for both the control of inflammatory autoimmune diseases and antigen receptor mediated activation of B and T cells, Immunity,19;37(4):685-96, 2012.
- Miao T, Raymond M, Bhullar P, Ghaffari E, Symonds AL, Meier UC, Giovannoni G, Li S, Wang P Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf. J Immunol. 2013 Jan 1;190(1):58-65. doi: 10.4049/jimmunol.1200868. Epub 2012 Nov 30.
- Li S, Symonds AL, Miao T, Sanderson I, Wang P. Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer. Front Immunol. 2014 Jun 17;5:293. doi: 10.3389/fimmu.2014.00293. eCollection 2014.