Education

Biography

Research Interest

• Immune responses in health and disease
• Neurologic diseases

Scientific Activities

Positions

Honours And Awards

• 1994:  Research Fellowship, Italian Association for Cancer Research (AIRC)
• 2007: today Editors Frontiers in HIV
• Ad hoc reviewer for Nature, Nature Immunology, Immunity, Journal of Experimental Medicine, Journal of Immunology, European Journal of Immunology and Journal of Leukocyte Biology.
• Temporary member of the Transplantation, Tolerance and Tumor Immunology (TTT) Study Section.
• Member of the American Association of Immunologists.

Publications

1. Obata F, Tsunoda M, Kaneko T, Ito K, Ito I, Masewicz S, Mickelson EM, Ollier WER, Pawelec G, Cella M, Ferrara GB, Kashiwagi N:  Human T-cell receptor TCRAV, TCRBV, and TCRAJ sequences newly found in T-cell clones reactive with allogeneic HLA class II antigens.  Immunogenetics 1993.38:67.
2. Pistillo MP, Cella M, Mantero S, Ferrara GB: Proliferation and Ig Secretion of LCLs are differently affected by soluble cytokines. Cell Proliferation.  1994.27:293.
3. Cella M, Longo A, Ferrara GB, Strominger JL, Colonna M:  NK3 specific Natural Killer cells are selectively inhibited by Bw4 positive HLA alleles with Isoleucine 80.  J Exp  Med 1994.180:1235.
4. Padovan E, Giachino C, Cella M, Valitutti S, Acuto O, Lanzavecchia A: Normal T lymphocytes can express two different T cell receptor b chain: implications for the mechanism of allelic exclusion. J Exp Med 1995.181:1587.
5. Valitutti S, Müller S, Cella M, Padovan E, Lanzavecchia A: Serial triggering of a large number of T-cell receptors by a few peptide-MHC complexes.  Nature 1995. 375:148.
6. Sallusto F, Cella M, Danieli C, Lanzavecchia A: Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen in the MHC class II compartment. Downregulation by cytokines and bacterial products. J Exp Med 1995.182:389.
7. Dohring C, Scheidegger D, Samaridis J, Cella M, Colonna M:  A human killer inhibitory receptor specific for HLA-A. J Immunol 1996.156:3098.
8. Campbell KS, Dessing M, Lopez-Botet, Cella M, Colonna M: Tyrosine phosphorylation of a human Killer Inhibitory receptor recruits Protein Tyrosine Phosphatase 1 C.  J Exp Med 1996.184:93.
9. Colonna M, Dohring C, Samaridis J, Scheidegger D, Dessing M, Cella M, Campbell K:  Human Killer Inhibitory receptors : specificity for HLA-class I molecules and mechanisms of signal transduction. Transplant Proc 1996.28:3035.
10. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G:  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996.184:747.
11. Tan MC, Mommaas AM, Drijfhout JW, Jordens R, Onderwater JJ, Verwoerd D, Mulder AA, van der Heiden AN, Ottenhoff TH, Cella M, Tulp A, Neefjes JJ, Koning F: Mannose receptor mediated uptake of antigens strongly enhaces HLA-class II restricted antigen presentation by cultured dendritic cells. Adv Exp Med Biol 1996.171:1997.
12. Engering AJ, Cella M, Fluitsma DM, Hoefsmit EC, Lanzavecchia A, Pieters J: Mannose receptor mediated antigen uptake and presentation in human dendritic cells. Adv Exp Med Biol 1997.417:183.
13. Uccini S, Sirianni MC, Vincenzi L, Topino S, Stopacciaro A, Lesnoni La Parola I, Capuano M, Masini C, Cerimele D, Cella M, Lanzavecchia A, Allavena P, Mantovani A: Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patients. Am J Pathol 1997.150:929.
14. Bruno L, Res P, Dessing M, Cella M, Spits H: Identification of a commited T cell precursor population in adult human peripheral blood. J Exp Med, 1997.185:875.
15. Cella M, Dohring C, Samaridis J, Dessing M, Brockaus M, Lanzavecchia A, Colonna M: A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med, 1997.185:1743.
16. Engering AJ, Cella M, Fluitsma D, Brockaus M, Hoefsmith ECM, Lanzavecchia A, Pieters J: The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. Eur J Immunol, 1997.27:2417.
17. Caux C, Massacrier C, Vanbervliet B, Dubois B, Durand I, Cella M, Lanzavecchia A, Bancherau J:  CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cells pathways in response to granulocyte- macrophage colony stimulating factor plus tumor necrosis factor alpha: II. Functional analysis. Blood, 1997.90:1458.
18. Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A: Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells.  Nature 1997.388:782.
19. Moliaka YK, Cella M, Chudina AP, Kolesnikova TN, Terraciano L, Cathomas G, Bochov N, Burstedde JM:  Mechanisms underlying mismatch repair deficiencies in normal cells. Genes, Chromosomes & Cancer 1997.20:305.
20. Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M: A common inhibitory receptor for Major Histocompatibility Class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 1997.186:809.
21. Capmbell KS, Cella M, Carretero M, Lopez-Botet M, Colonna M: Signaling through human killer  cell  activating  receptors  triggers tyrosine phosporylation of an associated protein complex.  Eur J Immunol 1998.28:599.
22. Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O’Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol 1998.160:3096.
23. Cella M, Salio M, Sakakibara Y, Langen H, Julkunen I, Lanzavecchia A: Maturation, activation, and protection of dendritic cells induced by double-stranded RNA.  J Exp Med 1999.189:821.
24. Nakajima H, Cella M, Langen H, Friedlein A, Colonna M:  Activating interactions in human NK cell recognition:the role of 2B4-CD48.  Eur J Immunol 1999.29:1676.
25. Banham AH, Colonna M, Cella M, Micklem KJ, Puldorf K, Willis AC, Mason DY: Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily. J Leukocyt Biol 1999.65:841.
26. Cella M, Jarrosay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, Colonna M: Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon” Nature Med 1999.5:919.
27. Salio M, Cella M, Suter M Lanzavecchia A: Inhibition of dendritic cell maturation by herpes simplex virus. Eur J Immunol 1999.29:3245.
28. Moins-Teisserenc HT, Gadola SD, Cella M, Dunbar PR, Exley A, Blake N, Baycal C, Lambert J, Bigliardi P, Willemsen M, Jones M, Buechner S, Colonna M, Gross WL, Cerundolo V: Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. Lancet 1999.354:1598.
29. Colonna M, Nakajima H, Cella M: Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells. J Leukoc Biol 1999.66:718.
30. Dietrich J, Cella M, Seiffert M, Buhring HJ, Colonna M:  Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.  J Immunol  2000.164:9.
31. Colonna M, Nakajima H, Cella M:  A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells. Semin Immunol 2000.12:121.
32. Cella M, Colonna M:  Cloning human natural killer cells.   Methods Mol Biol 2000.121:1.
33. Cella M, Facchetti F, Lanzavecchia A, Colonna M:  Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization.  Nat  Immunol  2000.1:305.
34. Dietrich J, Cella M, Colonna M:  Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization.  J Immunol 2001.166:2514.
35. Seiffert M, Brossart P, Cant C, Cella M, Colonna M, Brugger W, Kanz L, Ullrich A, Buhring HJ:  Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells.  Blood 2001.97:2741.
36. Bouchon A, Hernandez-Munain C, Cella M, Colonna M:  A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.  J Exp Med 2001.194:1111.
37. Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M:  Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family.  J Immunol 2001.167:5517.
38. Speiser DE, Colonna M, Ayyoub M, Cella M, Pittet MJ, Batard P, Valmori D, Guillaume P, Lienard D, Cerottini JC, Romero P: The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells.  J Immunol 2001.167:6165.
39. Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, Gunther G, Johnston I, Lanzavecchia A, Nagasaka T, Okada T, Vermi W, Winkel G, Yamamoto T, Zysk M, Yamaguchi Y, Schmitz J: BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.  J Exp Med 2001.194:1823.
40. 40.          Barchet W, Cella M, Odermatt B, Asselin-Paturel C, Colonna M, Kalinke U:   Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo.  J Exp Med 2002.195:507.
41. Facchetti F, Cella M, Festa S, Fremont DH, Colonna M:  An unusual Fc receptor-related protein expressed in human centroblasts.  Proc Natl Acad Sci USA 2002.99:3776.
42. Yu Kimata MT, Cella M, Biggins JE, Rorex C, White R, Hicks S, Wilson JM, Patel PG, Allan JS, Colonna M, Kimata JT:  Capture and transfer of simian immunodeficiency virus by macaque dendritic cells is enhanced by DC-SIGN.  J  Virol  2002.76:11827.
43. Gilfillan S, Ho SE, Cella M, Yokoyama WM, Colonna M:  NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.  Nat  Immunol 2002.3:1150.
44. Krug A, Facchetti F, Dorner BG, Sheehan KC, Schreiber RD, Cella M, Colonna M:  IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation.  J Immunol 2002.169:6079.
45. Fehniger TA, Cooper MA, Nuovo GJ, Cella M, Facchetti F, Colonna M, Caligiuri MA: CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.  Blood 2003.101:3052.
46. Krug A, Veeraswamy R, Pekosz A, Kanagawa O, Unanue ER, Colonna M, Cella M:  Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper differentiation of antigen-experienced unpolarized T cells.  J Exp Med 2003.197:899.
47. Salio M, Cella M, Vermi W, Facchetti F, Palmowski MJ, Smith CL, Shepherd D, Colonna M, Cerundolo V: Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.   Eur J Immunol 2003.33:1052.
48. Vermi W, Bonecchi R, Facchetti F, Bianchi D, Sozzai S, Festa S, Berenzi A, Cella M, Colonna M:  Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas.  J Pathol  2003.200:255.
49. Veeraswamy RK, Cella M, Colonna M, Unanue ER:  Dendritic cells process and present antigens across a range of maturation states.  J Immunol 2003.170:5367.
50. Cella M, Buonsanti C, Strader C, Kondo T, Salmaggi A, Colonna M:  Impaired differentiation of osteoclasts in TREM-2-deficient individuals.  J Exp  Med  2003.198:645.
51. Whelan KT, Lin CL, Cella M, McMichael AJ, Austyn JM, Rowland-Jones SL: The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration.  Eur  J  Immunol  2003.33:2520.
52. Blasius A, Vermi W, Krug A, Facchetti F, Cella M, Colonna M:  A cell surface molecule selectively expressed on murine Natural Interferon Producing Cells that blocks secretion of interferon-alpha.  Blood 2004.103:4201.
53. Coccia EM, Severa M, Giacomini E, Monneron D, Remoli ME, Julkunen I, Cella M, Lande R, Uze G:  Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells.  Eur J  Immunol  2004.34:796.
54. Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M:  CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).  J  Immunol  2004.172:3994.
55. Cella M, Fujikawa K, Tassi I, Kim S, Latinis K, Nishi S, Yokoyama W, Colonna M, Swat W: Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.  J Exp  Med  2004.200:817.
56. Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F, Cella M, Colonna M:  Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T-cell proliferation.  Blood 2005.105:2421.
57. Barchet W, Krug A, Cella M, Newby C, Fischer JA, Dzionek A, Pekosz A, Colonna M:  Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways.  Eur  J  Immunol 2005.35:236.
58. Huang S, Gilfillan S, Cella M, Miley MJ, Lantz O, Lyberger L, Fremont DH, Hansen TD:  Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.  J  Biol  Chem  2005.280:21183.
59. Boles KS, Barchet W, Diacovo T, Cella M, Colonna M:  The tumor suppressor TSLC1/NECL-2 triggers NK cell and CD8+ T cell responses through the cell surface receptor CRTAM.  Blood 2005.106:779.
60. Fuchs A, Cella M, Kondo T, Colonna M:  Paradoxical inhibition of human natural interferon-producing cells by the activating receptor NKp44.  Blood 2005.106:2076.
61. Barchet W, Cella M, Colonna M:  Plasmacytoid dendritic cells--virus experts of innate immunity.  Seminar Immunol 2005.17:253.
62. Diacovo TG, Blasius AL, Mak TW, Cella M, Colonna M:  Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes.  J Exp Med 2005.202:687.
63. Barchet W, Price JD, Cella M, Colonna M, MacMillan SK, Cobb JP, Thomson PA, Murphy KM, Atkinson JP, Kemper C: Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation.  Blood 2006.107:1497.
64. Blasius AL, Cella M, Maldonado J, Takai T, Colonna M:  Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12.  Blood  2006.107:2474.
65. Hagnerud S, Manna PP, Cella M, Stenberg A, Frazier WA, Colonna M, Oldenborg PA. Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration. J Immunol. 2006.176:5772.
66. Graham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppel T, Brim K, Takai T, Shaw AS, Colonna M, Swat W. Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J Immunol. 2006.177:2349.
67. Blasius AL, Giurisato E, Cella M, Schreiber RD, Shaw AS, Colonna M. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol. 2006.177:3260.
68. Turnbull IR, Gilfillan S, Cella M, Aoshi T, Miller M, Piccio L, Hernandez M, Colonna M. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol. 2006.177:3520.
69. Piccio L, Buonsanti C, Mariani M, Cella M, Gilfillan S, Cross AH, Colonna M, Panina-bordignon P.  Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.  Eur J Immunol 2007.37:1290.
70. Tassi I*, Cella M*, Gilfillan S, Turnbull I, Diacovo TG, Penninger JM, Colonna M. p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity 2007.27:214. *equal contribution as first author.
71. Blasius AL, Barchet W, Cella M, Colonna M. Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J Exp Med. 2007.204:2561.
72. Giurisato E, Cella M, Takai T, Kurosaki T, Feng Y, Longmore GD, Colonna M, Shaw AS: Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.  Mol Cell Biol 2007.27:8583.
73. Colonna M, Cella M:  Crosspresentation: plasmacytoid dendritic cells are in the business.  Immunity 2007.27:419.
74. Kim S, Sunwoo JB, Yang L, Choi T, Song YJ, French AR, Vlabiotis A, Piccirillo JF, Cella M, Colonna M, Mohanakumar T, Hsu KC, Dupont B, Yokoyama WM.  HLA alleles determine differences in human natural killer cell responsiveness and potency.  Proc Natl Acad Sci USA 2008.105:3053.
75. Piccio L, Buonsanti C, Cella M, Tassi I, Schmidt RE, Fenoglio C, Rinker J 2nd, Naismith RT, Panina-Bordignon P, Passini N, Galimberti D, Scarpini E, Colonna M, Cross AH.  Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation.  Brain 2008.131:8081.
76. Tassi I, Cella M, Presti R, Colucci A, Gilfillan S, Littman DR, Colonna M.  NK cell activating receptors require PKCq for sustained signaling, transcriptional activation and IFN-g secretion.  Blood 2008.112:4109.
77. Gilfillan S, Chan CJ, Cella M, Haynes NM, Rapaport AS, Boles KS, Andrews DM, Smyth MJ, Colonna M.  DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.  J Exp Med 2008.205:2965.
78. Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lenerz JK, Doherty JM, Mills JC, Colonna M.  A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity.  Nature 2009.457:722. 
79. Giurisato E, Lin J, Harding A, Cerutti E, Cella M, Lewis RE, Colonna M, Shaw AS:  The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.  Mol Cell Biol 2009.29:1554.
80. McCartney S, Vermi W, Gilfillan S, Cella M, Murphy TL, Schreiber RD, Murphy KM, Colonna M. Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med 2009.206:2967.
81. Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M:  A novel molecular interaction for the adhesion of follicular CD4 T cells in follicular DC.  Eur J Immunol 2009.39:695.
82. Norian LA, Rodriguez PC, O’Mara LA, Zabaleta J, Ochoa AC, Cella M, Allen PM: Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.  Cancer Res 2009.69:3086.
83. Tassi I, Cella M, Castro I, Gilfillan S, Shan WN, Colonna M:  Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of T(H)1/T(H)17 polarization.  Eur J Immunol 2009.39:1369.
84. Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M: Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.  PLoS Pathog 2010 6:e1000734.
85. Wang Y, Cella M, Gilfillan S, Colonna M:  Cutting edge: Polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.  J Immunol 2010.184:2751.
86. Cella M, Otero K, Colonna M:  Expansion of human NK-22 cells with IL-7, IL-2, and IL-1 beta reveals intrinsic functional plasticity.  Proc Natl Acad Sci USA 2010.107:10961.
87. Cella M, Presti R, Vermi W, Lavender K, Turnbull E, Ochsenbauer-Jambor C,   Kappes JC, Ferrari G, Kessels L, Williams I; CHAVI Clinical Core B, McMichael AJ, Haynes BF, Borrow P, Colonna M; NIAID Center for HIV/AIDS Vaccine Immunology. Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. Eur J Immunol  2010.40:949.
88. Graham DB, Akilesh HM, Gmyrek GB, Piccio L, Gilfillan S, Sim J, Belizaire R, Carrero JA, Wang Y, Blaufuss GS, Sandoval G, Fujikawa K, Cross AH, Russell JH, Cella M, Swat W. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood 2010.116:3208.
89. Cremasco V, Benasciutti E, Cella M, Kisseleva M, Croke M, Faccio R. Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One 2010. 5(1):e8909.
90. Barrow AD, Raynal N, Andersen TL, Slatter DA, Bihan D, Pugh N, Cella M, Kim T, Rho J, Negishi-Koga T, Delaisse JM, Takayanagi H, Lorenzo J, Colonna M, Farndale RW, Choi Y, Trowsdale J. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest 2011.121:3505.
91. Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol. 2011.13:144.
92. Wang Y, Swiecki M, Cella M, Alber G, Schreiber RD, Gilfillan S, Colonna M. Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. Cell Host Microbe 2012.11:631.
93. Otero K, Shinohara M, Zhao H, Cella M, Gilfillan S, Colucci A, Faccio R, Ross FP, Teitelbaum SL, Takayanagi H, Colonna M. TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. J Immunol 2012.188:2612.
94. Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, Cella M, Bernal-Mizrachi C. Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem 2012.287:11629.
95. Wang Y, Szretter KJ, Vermi W, Gilfillan S, Rossini C, Cella M, Barrow AD, Diamond MS, Colonna M. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol 2012.13:753. 
96. Fuchs A, Vermi W, Lee JS, Lonardi S, Gilfillan S, Newberry RD, Cella M, Colonna M. Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells. Immunity. 2013. 38:769.
97. Fabbrini E*, Cella M*, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S. Association Between Specific Adipose Tissue CD4(+) T-Cell Populations and Insulin Resistance in Obese Individuals. Gastroenterology. 2013. 145:366. * equal contribution as first author.
98. Srivatsan S, Swiecki M, Otero K, Cella M, Shaw AS. CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production. J Immunol. 2013. 191:5933.
99. Lubman OY, Cella M, Wang X, Monte K, Lenschow DJ, Huang YH, Fremont DH. Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor. J Virol. 2014. 88:538.
100. KC W, Satpathy AT, Rapaport AS, Briseño CG, Wu X, Albring JC, Russler-Germain EV, Kretzer NM, Durai V, Persaud SP, Edelson BT, Loschko J, Cella M, Allen PM, Nussenzweig MC, Colonna M, Sleckman BP, Murphy TL, Murphy KM. L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature. 2014. 507:243.
101. Cortez VS, Fuchs A, Cella M, Gilfillan S, Colonna M. Salivary gland NK cells develop independently of Nfil3 in steady-state. Cutting edge: J Immunol. 2014.192:4487.
102. Chou C, Pinto AK, Curtis JD, Persaud SP, Cella M, Lin CC, Edelson BT, Allen PM, Colonna M, Pearce EL, Diamond MS, Egawa T. c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells. Nat Immunol. 2014.15:884.
103. Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. 2015. 160:1061.
104. Chung JJ, Huber TB, Gödel M, Jarad G, Hartleben B, Kwoh C, Keil A, Karpitskiy A, Hu J, Huh CJ, Cella M, Gross RW, Miner JH, Shaw AS. Albumin-associated free fatty acids induce macropinocytosis in podocytes. J Clin Invest. 2015.125:2307.
105. Song C, Lee JS, Gilfillan S, Robinette ML, Newberry RD, Stappenbeck TS, Mack M, Cella M, Colonna M. Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med. 2015. 212:1869. Co-corresponding author.
106. Rapaport AS, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel BF, Wang Y, Le Friec G, Gao J, Cella M, Pircher H, Yokoyama WM, Buller RM, Colonna M. The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8(+) T Cells in Response to a Lethal Poxvirus Infection. Immunity. 2015. 43:1112.
107. Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J Exp Med. 2016. 213:667.
108. Cortez VS, Cervantes-Barragan L, Robinette ML, Bando JK, Wang Y, Geiger TL, Gilfillan S, Fuchs A, Vivier E, Sun JC, Cella M, Colonna M. Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands. Immunity. 2016. 44:1127.
109. Koues OI*, Collins PL*, Cella M*, Robinette ML*, Porter SI, Pyfrom SC, Payton JE, Colonna M, Oltz EM. Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells. Cell. 2016. 165:1134. * equal contribution as first author.
110. Wu D, Sanin DE, Everts B, Chen Q, Qiu J, Buck MD, Patterson A, Smith AM, Chang CH, Liu Z, Artyomov MN, Pearce EL, Cella M, Pearce EJ. Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function. Immunity. 2016. 44:1325.
111. Song W, Hooli B, Mullin K, Jin SC, Cella M, Ulland TK, Wang Y, Tanzi R, Colonna M. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimers Dement. 2016. 667:30203.
112. Chou C, Verbaro DJ, Tonc E, Holmgren M, Cella M, Colonna M, Bhattacharya D, Egawa T. The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity. 2016. 45:570.
113. Swiecki M, Miller HL, Sesti-Costa R, Cella M, Gilfillan S, Colonna M. Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state. Mucosal Immunol. 2016.