Education

Postdoctoral Training:

Biography

Research Interest

My primary research interests are focus on understanding the basic features of the molecular biology of infectious diseases with special attention on those regarding to parasitic pathogens belonging to the Kinetoplastid genus. During the life cycle of a pathogen, developmental transitions that shape their size and morphology, need to be done in a very fast way via the expression of thousand of genes in a very coordinated manner.  Kinetoplastids are singular and stunning with regard to the expression and regulation of their genes, being this expression mostly controlled by epigenetic and post-trascriptional processes.  The goal of my current research is to understand how the mRNA is modulated by those kinetoplastid pathogens, by using High-throughput sequencing and novel biochemical approaches, which likewise, could be applied to other diseases.

Professional Activities:

Publications

• Mohamed Fawzi E., Cruz Bustos T, G., Gómez Samblas M., González-González G,., Solano J.,  González-Sánchez ME., De Pablos LM., Corral-Caridad MJ.,  Cuquerella M,., Osuna A., Alunda JM. Clin. Vaccine Immunol. (2013), 20: 1352-9.
• De Pablos, L.M and Osuna, A. Multigene families in Trypanosoma cruzi and their Role in Infectivity. Infect Immun. (2012), 80: 2258-64.
• De Pablos, L.M and Osuna, A. Conserved regions as markers of patterns of different expression and distribution of the mucin-associated surface proteins of Trypanosoma cruzi. Infect Immun. (2012). 80 :169-74.
• De Pablos, L.M., González, G., Solano Parada, J. et al. Seco Hidalgo, V., Díaz Lozano, I.M.,Gómez Samblás M., Cruz, T., and Osuna, A. Differential expression and characterization of a member of the mucin-associated surface proteins (MASP) family secreted by Trypanosoma cruzi. Infect Immun. (2011). 79: 3993-4001.
• Cura, C.I., Mejía-Jaramillo, A.M., Duffy, T., Burgos, J.M., Rodriguero, M., Cardinal, M.V.,Kjos, S., Gurgel, Gonçalves, R., Blanchet, D., De Pablos, L.M., Da Silva, A.,Russomando, G., Cuba, C.A. , Aznar, C., Abate, T., Levin, M.J., Osuna, A., Gürtler, R.E.,Diosque, P., Solari, A.,Triana-Chávez, O., and Schijman, A.G. Trypanosoma cruzi I haplogroups in American countries based on spliced-leader intergenic spacer polymorphism. Int J Parasitol. (2010). 40:1599-607.
• Solano-Parada, J., Gonzalez-Gonzalez, G., De Pablos, L.M., Brazil Dos Santos M.F., Espino, A.M., Burgos, M., Osuna, A. Effectiveness of intranasal vaccination against Angiostrongylus costaricensis using a serine/threonine phosphatase 2 A synthetic peptide and recombinant antigens. Vaccine. (2010). 28:5185-5196.
• De Pablos, L.M., González, G., Rodrigues, R., García Granados, A., Parra, A., Osuna, A. Action of a pentacyclic triterpenoid, maslinic acid, against Toxoplasma gondii. J Nat Prod.
• (2010) 73:831-4.
• De Pablos LM, Dos Santos, M.F., Montero, E., Garcia-Granados, A., Parra, A., Osuna, A.Anticoccidial activity of maslinic acid against infection with Eimeria tenella in chickens. Parasitol Res. (2010) 107:601-4.
• Lorenzo-Morales, J., Kliescikova, J., Martinez-Carretero, E., De Pablos, L.M., Profotova, B., Nohynkova, E., Osuna, A., Valladares, B.. Glycogen phosphorylase in Acanthamoeba spp.: determining the role of the enzyme during the encystment process using RNA interference. Eukaryot Cell. (2008) 7:509-17.
• Zulantay, I., Apt, W., Gil, L.C., Rocha, C., Mundaca, K., Solari, A., Sánchez, G., Rodriguez, C., Martínez, G., De Pablos, L.M., Sandoval, L., Rodríguez, J., Vilchez, S., Osuna, A.The PCR-based detection of Trypanosoma cruzi in the faeces of Triatoma infestans fed on patients with chronic American trypanosomiasis gives higher sensitivity and a quicker result than routine xenodiagnosis. Annals Trop Med Hyg (2007). Dec; 101(8): 673-9.
• Maache, M., Azzouz, S., Diaz de la Guardia, R., Alvarez, P., Gil, R.,De Pablos, L.M., and Osuna, A. Host humoral immune response to Leishmania fatty-acid-binding protein. Parasite Immunol.(2005) 27: 227-234.