- : (717) 531-0003 / Ext. 287768 : (717) 531-4600
Department of Microbiology & Immunology
Pennsylvania State University College of Medicine
1985 – 1989
B.Sc. (Biology) Chongqing University, China.
1990 – 1993
M.Sc. (Immunology) The Third Military Medical University, China.
1995 – 2001
Ph.D. (Immunology) The Third Military Medical University, China.
2001 – 2004
Post-doc (Immunology) La Jolla Institute for Allergy & Immunology. CA.
Dr. Jianxun (Jim) Song is a tenured associate professor in the Department of Microbiology and Immunology, the Pennsylvania State University College of Medicine, United States. The base of expertise on T cell biology needed to perform his research began to develop while he was a postdoctoral scholar and research scientist from the years 2001-2007 under the mentorship of Dr. Michael Croft at the La Jolla Institute for Allergy and Immunology. He became a junior faculty at The Pennsylvania State University College of Medicine in 2007, and extended his research on
Developmental Immunology and Stem Cell Biology. As a PI on previous university-, foundation-, or NIH-funded grants, he laid the groundwork for the research by developing highly reactive T lymphocytes from pluripotent stem cells (PSC). His laboratory was the first to show that induced PSC differentiate into functional T cells for cell-based therapies. In addition to having the expertise to be successful with the research, he offers leadership and administrative skills that were developed during his independence as a mentor of graduate students and postdoctoral scholars. In summary, he has a demonstrated record of successful and productive research projects in the area.
Costimulation in T lymphocyte memory
Costimulatory signals expressed by professional antigen presenting cells (APC) are capable of promoting the formation of highly active effector T cell, which are able to develop into memory populations. However, the mechanisms by which constimlation regulates T lymphocyte memory remain uncertain. Several molecular targets of costimulation (e.g., aurora B, survivin, bcl-xL, PKB) have been identified to sustain T cell proliferation or survival, and their cooperation in promoting T cell persistence as well as tumor regression is being investigated. Findings related to this project will provide new insights into why costimulatory signals might need to be sustained over time and suggest a potential novel approach to augment cellular immunotherapy for cancer.
Regulation of differentiation of T lymphocytes from pluripotent stem cells
Most effort is being expended to develop and optimize strategies for utilizing highly reactive T lymphocytes from pluripotent stems cells (PSC) for cell-based therapies. Because of the plasticity and potentially unlimited capacity for self-renewal, PSC-derived immune cells have great potential in the treatment of diseases (e.g., cancers, autoimmune diseases). Antigen-specific highly reactive T cells can be generated by genetic modification of PSC with specific T cell receptor and stimulation with Notch signaling, and their therapeutic potential in the treatment of cancers and autoimmune diseases is being determined. Findings related to this project will contribute important information in the areas of vaccine design, autoimmune therapy, and immune-based anti-cancer strategies.
- 7/1/2014 – present Tenured Associate Professor, Department of Microbiology and Immunology,The Pennsylvania State University College of Medicine, Hershey, PA 17033.
- 9/1/2007 – 6/30/2014 Tenure-Track Assistant Professor, Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
- 7/1/2004 – 8/1/07 Research Scientist, Division of Molecular Immunology, La Jolla Institute for Allergy & Immunology. La Jolla, CA 92037.
- American Association for Cancer Research (AACR, from 2010)
- American Association of Immunologist (AAI, from 2003)
Awards and Honors
2009 - 2014
AAI Junior Faculty Travel Awards (Seattle, Baltimore, Boston, Honolulu, and Pittsburgh)
2011 - 2013
Dean’s Awards for Excellence in Teaching (Penn State University College of Medicine)
2014 - 2015
Graduate Council, The Graduate School, Penn State University
Postdoctoral Mentorship Award (Penn State University College of Medicine) 2014 – 2015 Woodward Education Scholar Award
Journal Manuscript Review
Journal of Clinical Investigation, Cancer Research, Blood, Vaccine, Viral Immunology, Cell Death and Differentiation, Cellular Immunology, Cellular and Molecular Life Sciences, Antiviral Research, Pediatrics, Journal of Pediatrics, Journal of Immunology, Journal of Genetics and Genomics, Journal of Cardiovascular Pharmacology, Cancer Biology & Therapy, African Journal of Biotechnology, Cancer Immunology and Immunotherapy, Journal of Viral Hepatitis, PloS Pathogens, Clinical Transplantation, Stem Cells and Development, PloS One. International Immunopharmacology, Oxidative Medicine and Cellular Longevity, CellBio, International Journal of Molecular Sciences, African Journal of Microbiology Research. World Journal of Clinical Cases
- Course director 2011: Literature Reports (MICRO 572)
- Course director 2011 – 2013: Concepts in Immunology (CMBIO/MICRO 560).
Lecturers - T cell co-stimulation, T lymphocyte memory, Regulatory T cells.
- Song J (2014). Frontiers in Cancer Immunotherapy - Mechanisms of cancer immunity, engineering immune-based therapies and developing clinical trials. Bentham Science Publishers, UAE, in press
- Lei F, Haque R, Xiong X, and Song J (2014). Modulation of autoimmune diseases by iPS cells. Animal Models for Stem Cell Therapy: Methods and Protocols. Springer Science, New York
- Lei F, Haque R, Xiong X, and Song J (2014). Generation of antigen-specific T lymphocytes from induced pluripotent stem cells for adoptive immunotherapy. Stem Cells and Cancer Stem Cells, Volume 10. Springer Science, Dordrecht
- Haque R, Lei F, Xiong X, and Song J (2012). Stem cell-based cellular therapy in rheumatoid arthritis. Autoimmune Diseases. InTech Europe
- Croft M, Salek-Ardakani S, Song J, So T, and Bansal-Pakala P (2003). Regulation of T cell immunity by OX40 and OX40L. The TNF Superfamily. Landes Bioscience, Texas.
- Haque M, Fino K, Lei F, Xiong X, and Song J (2014). Utilizing regulatory T cells against rheumatoid arthritis. Front Oncol, 4: 209
- Aĝirbaşli MA, Song J, Lei F, Wang S, Kunselman AR, Clark JB, Myers JL, Ündar A (2014).Comparative effects of pulsatile and nonpulsatile flow on plasma fibrinolytic balance in pediatric patients undergoing cardiopulmonary bypass. Artif Organs, 38(1): 28-33
- Tian Y, Ni D, Yang W, Zhang Y, Zhao K, Song J, Mao Q, Tian Z, van Velkinburgh JC, Yang D, Wu Y, Ni B (2014). Telbivudine treatment corrects HBV-induced epigeneticalterations in liver cells of patients with chronic hepatitis B. Carcinogenesis, 35(1): 53-61.
- Lei F, Song J, Haque R, Xiong X, Fang D, Wu Y, Lend SM, Croft M and Song J (2013).Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol, 43 (7): 1914-1924. PMCID: PMC3876962
- Lei F, Song J, Haque R, Xiong X, Fang D, Croft M and Song J (2013). Regulation of A1 by OX40 contributes to CD8 T cell survival and anti-tumor activity. PLoS One, 8(8): e70635. PMCID: PMC3731243
- Kemp KL, Lin Z, Zhao F, Gao B, Song J, Zhang K, Fang D (2013). The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem, 288(46): 33272-82. PMCID: PMC3829173
- Tian Y, Yang W, Song J, Wu Y, Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. Mol Cell Biol, 33(15): 2810-6. PMCID: PMC3719687
- Haque R, Lei F, Xiong X, Bian Y, Zhao B, Wu Y and Song J (2012). Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol 189 (3): 1228-1236. PMCID: PMC3401327
- Lei F, Haque R, Xiong X, and Song J (2012). Directed differentiation of induced pluripotent stem cells towards T lymphocytes. J Vis Exp. (63), e3986. PMCID: PMC3389997
- Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD, and Fang D (2012). USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development. Mol Cell, 46(4): 484-494. PMID: 22542455
- Lei F, Haque R, Xiong X, Budgeon L, Christensen ND, Wu Y and Song J (2011). In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. Cancer Res, 71(14): 4742-4747. PMID: 21628492
- Tian Y, Jia Z, Wang J, Huang Z, Tang J, Zheng Y, Tang Y, Wang Q, Tian Z, Yang D, Zhang Y, Fu X, Song J, Liu S, van Velkinburgh JC, Wu Y, Ni B (2011). Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. PLoS One. 2011; 6(11):e27770. PMID: 22132139
- Haque R, Lei F, Xiong X, and Song J (2011). The regulation of FoxP3-expressing regulatory T cells. Endocr Metab Immune Disord Drug Targets, 11: 334-336. PMID: 21696363
- Haque R, Lei F, Xiong X, Wu Y, and Song J (2010). FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther 12(2): R66. PMID 19454669
- Lei F, Haque R, Weiler L, Vrana KE, and Song J (2009). T lineage differentiation from induced pluripotent stem cells. Cell Immunol 260 (1): 1-5. PMID 19811778
- Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, Wu Y, Croft M, and Song J (2009). Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol 182 (11): 6744-6752. PMID 19454669
- Song J, So T and Croft M (2008). Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol 180(11): 7240-7248. PMCID: PMC2410213
- Song J, Lei F, Xiong X and Haque R (2008). Intracellular signals of T cell costimulation. Cell Mol Immunol 5 (4): 239-247. PMID 18761811
- Song J, Salek-Ardakani S, So T, and Croft M (2007). The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol 8 (1): 64-73. PMID: 17128276
- Song A, Song J, Tang X, Croft M (2007). Cooperation between CD4 and CD8 T cells foranti-tumor activity is enhanced by OX40 signals. Eur J Immunol 37(5): 1224-1232. PMID 17429847
- So T, Song J, Sugie K, Altman A, and Croft M (2006). Signals from OX40 regulate NFATc1 and Th2 lineage commitment. Proc Natl Acad Sci U S A 103(10): 3740-3745. PMCID: PMC1450148
- Song J, So T, Cheng M, Tang X and Croft M (2005). Sustained Survivin expression from OX40 costimilatory signals drives T cell clonal expansion. Immunity 22(5): 621-631. PMID 15894279
- Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP, Altman A (2005). Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8): 5126-5134. PMID: 16210616
- Song J, Salek-Ardakani S, Rogers PR, Cheng M, Parijs LV, and Croft M (2004). The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol 4(2): 150-158. PMID 4730361
- Lawson BR, Baccala R, Song J, Croft M, Kono DH, Theofilopoulos AN (2004). Deficiency of the Cyclin Kinase Inhibitor p21 (WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells and Inhibits Spontaneous Systemic Autoimmunity. J Exp Med
199(4): 547-557. PMCID: PMC2194076
- Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, Croft M (2003). OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 198(8): 315-324. PMCID: PMC2194076
- Rogers PR1, Song J1, Gramaglia I, Killeen N and Croft M (2001). OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 14(9): 445-455 (1: joint first authorship). PMID 19454669 (There are additional 20 research papers published in non-English journals)
|2013||Directed tumor-specific iPSC-CTL for cancer immunotherapy. June 16, 2013. University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute.|
|2013||Directed T lymphocytes from pluripotent stem cells for adoptive immunotherapy. May 21, 2013. Institute of Human Virology, University of Maryland School of Medicine.|
|2014||Development of T lymphocytes from induced pluripotent stem cells for adoptive immunotherapy. The 8th Symposium of Molecular and Cellular Immunity, January 09-15, 2013, Chongqing, China|
|2012||Development of T lymphocytes from induced pluripotent stem cells for adoptive immunotherapy. November 5, 2012, Department of Biochemistry and Molecular Biology, Penn State University College of Medicine.|
|2011||Impact of iPS cell-derived antigen-specific CTL on cancer. June 30, 2011, Hebei Normal University College of Life Science, Shijiazhuang, China.|
|2011||Programming of induced stem cells into antigen-specific T lymphocytes for cancer therapy. 10th Annual Minisymposium on Melanoma. May 23, 2011, The Penn State University College of Medicine.|
|2010||Generation of highly reactive CTLs from iPS cells. 13th Annual Meeting of the Translational Research Cancer Center Consortium (TRC3). March 1 - 2, 2010, The Ohio State University, Columbus, Ohio.|
|2009||Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. The 12th Upstate New York Immunology Conference, November 25-27, 2009, Sagamore Resort, New York.|
|2007||Synergy between molecular targets of costimulation in promoting persistence of CD8+ T cells. International Conference on Immunology 2007, July 12-15, 2007, Shanghai, China|
|2006||Molecular basis of T cell costimulation. The 7th Symposium of Molecular and Cellular Immunity, November 18-22, 2006, Chongqing, China|