Bin Gong, MD, PhD
Associate Professor of Pathology

University of Texas Medical Branch
Galveston, Texas, USA
Phone: (409) 266-6934/(409) 266-6682
Email: bigong@UTMB.EDU


Degree Institution Field of Study Graduation Year
M.D. Second Military Medical University, Shanghai, China Medicine 1990
Ph.D. Second Military Medical University, Shanghai, China Experimental Cardiothoracic Research Science 1996
Postdoctoral University of Texas Medical Branch, Galveston, TX Experimental Pathology 2007


Bin Gong is a Associate Professor in Department of pathology, Faculty Member in The Center of Biodefense and Emerging Infectious Diseases. He has eleven years’ research experience involving experimental tomographic-pathologic studies of microvascular diseases with emphasis on mechanisms of integrity of endothelial junctions and extracellular matrices, as well as past research experience with cardiovascular diseases. His research focus is to develop post-transcriptional or translational regulation strategies to protect endothelial cells during infection with intracellular pathogens, most notably Rickettsia spp.

Research Interest

  • To Develop Post-Transcriptional or Translational Regulation Strategies
  • Past research experience with cardiovascular diseases

Scientific Activities

Professional and teaching experience

2012 Director,sncRNAomics and Experimental Pathology in the Galveston National LaboratoryDepartment of Pathology,UTMBGalveston, TX
2011–2013 Associate Scientific Director, Experimental Pathology CoreDepartment of Pathology,UTMB,Galveston, TX
2010 Assistant Professor (Tenure-track),Department of Pathology,UTMB,Galveston, TX
2007–2010 Research Scientist and Assistant Scientific Director, Experimental Pathology Core,Department of Pathology,UTMB,Galveston, TX
2004–2007 Instructor/Fellow,Center for Interdisciplinary Research in Women’s Health,UTMB,Galveston, TX
1997–2000 Faculty-Associate Senior Researcher and Attending SurgeonDepartment of Cardiothoracic Surgery,Changhai Hospital,Shanghai, China
1996–1997 Chief Resident,Department of Cardiothoracic Surgery,Faculty and Attending Surgeon of General Thoracic Surgery,Changhai Hospital,Shanghai, China
1990–1996 Resident ,Department of Surgery, Changhai Hospital, Shanghai, China
Membership in scientific societies/professional organizations

2012 The RNA Society
2008 The United States & Canadian Academy of Pathology (USCAP)
2008 American Society for Clinical Pathology (ASCP)
2004 North American Vascular Biology Organization (NAVBO)
Honours And Awards
  • 2006 - Travel Award (“Imaging of Extracellular Matrix in  Chemical- induced      Developmental Dissecting Aortic Aneurysm using Multiphoton Fluorescence and Second Harmonic Generation Microscopy: Defective Collagen Type 3”)  Weinstein Cardiovascular Development Conference, St. Petersburg, FL
  • 2005 - First Place Postdoctoral Fellow Award (“Morphogenic Study on Dissecting Aortic Aneurysm with Multiphoton and Second Harmonic Generation Microscopy”) Department of Pathology UTMBGalveston, TX
  • 2005 - Third Place Society of Toxicology Trainee Award 2005 (“Fetal Basis of Dissecting Aortic Aneurysm”)National Institute of Environmental Health Sciences, New Orleans, LA                                      
  • 2005 - Outstanding Achievement Award (“Morphologic Study of Extracellular Matrix in Chemical-induced Developmental Dissecting Aortic Aneurysm Using Multiphoton Florescence and Second Harmonic Generation Microscopy”)2005 Society of Toxicology Meeting, New Orleans, LA                           
  • 2005 - Second Place Postdoctoral Fellow Award (“Efficient Transgene Expression of Glutathione-s-transferases [GST] in Cardiovascular Cells and Tissues Mediated by Adenoviral Vectors”) Department of Pathology, UTMB, Galveston, TX                                           
  • 2004 - First Place Postdoctoral Fellow Award (“A Developmental Dissecting Aortic Aneurysm Model”)Department of   Pathology, UTMB, Galveston, TX
  • 2004 - Best Poster Award (“Cardiac Preconditioning with InfraredLaser Irradiation Heating”)International Education Week Scientific Poster,UTMB, Galveston, TX


Yang LQ, Yu WF, Cao YF, GONG B, Chang Q, Yang GS. Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes. World Journal of Gastroenterology. 2003 9:1959-62.
2. GONG B, Boor PJ. The role of amine oxidases in xenobiotic metabolism. Expert Opinion on Drug Metabolism & Toxicology 2006 2:559-71.
3. GONG B, Trent MB, Srivastava D, Boor PJ. Chemical induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth Defects Research Part A: Clinical and Molecular Teratology 2006 76:29-38.
4. Boor PJ, Yang Y, GONG B. Role of the media in vascular injury: Atherosclerosis and dissection. Toxicologic Pathology 2006 34:33-38.
5. GONG B, Asimakis GK, Chen Z, Albrecht TB, Boor PJ, Pappas TC, Bell B, Motamedi M. Whole-body hyperthermia induces up-regulation of vascular endothelial growth factor accompanied by neovascularization in cardiac tissue. Life Sciences 2006 79:1781-8.
6. Xu Y, GONG B, Yang Y, Awasthi YC, Woods M, Boor PJ. Glutathione-S-transferase protects against oxidative injury of endothelial cell tight junctions. Endothelium. 2007 14:333-43.
7. GONG B, Sun J. Sun J, Vargas G, Chang Q, Xu Y, Srivastava D, Boor PJ. Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III.  Birth Defects Research Part A: Clinical and Molecular Teratology 2008 82:16-24.
8. GONG B, Bell B, Boor PJ, Albrecht TB, Asimakis GK, Motamedi M. Cardiac preconditioning with local laser-induced hyperthermia. Journal of Surgical Research 2008 149:177-83.
9. Xu Y, GONG B, Yang Y, Awasthi YC, Boor PJ. Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts. Transplantation. 2010 89:409-16.
10. Desai MM, GONG B, Chan T, Davey RA, Soong L, Kolokoltsov AA, Sun J. Differential, type I interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver. Gastroenterology. 2011;141(2):674-85.
11. Welte T, Aronson J, GONG B, Mendell N,  Rachamallu A, Tesh R, Paessler S, Born W, O’Brien R, Wang T. V4+ T cells suppress V1+ T cell response during West Nile virus infection. FEMS Immunology and Medical Microbiology 2011 Nov;63(2):183-92.
12. Xin L; Shelite TR; GONG B; Soong L; Fang R; Walker DH. Systemic treatment with CpG-B after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (IDO). PLoS One 2012;7(3): e34062.
13. Cao AT , Yao S, GONG B, Elson CO, Cong Y. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. Journal of Immunology 2012 Nov;189(9):4666-73. PMCID:PMC3478497
14. Kunkeaw N, Jeon SH, Lee K, Johnson BH, Wongfieng W, Chamgramol Y, GONG B, Leelayuwat C, Lee YS. Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma. Oncogen 2012;382-1-10. PMID:22926522.
15. Jeon SH, Lee B, Kunkeaw N, Johnson BH, Holthauzen LMF, GONG B, Leelayuwat C, Lee YS. Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR. FEBS Letters 2012 Sep:586(19):3477-84. PMID:22986343.
16. Lihoradova O, Kalveram B, Indran SV, Nandadeva L, Juelich TL, Hill TE, Tseng C-TK, GONG B, Fukushi S, Morikawa S, Freiberg AN, Ikegami T. The dominant-negative inhibition of dsRNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 Vaccine.  Journal of Virology. 2012;86(14):7650-7661.  PMCID: PMC3416293.
17. GONG B (Corresponding author), Ma L, Liu Y, Gong Q, Shelite T, Bouyer D, Boor PJ, Lee YS, Oberhauser A. Rickettsiae induce microvascular hyperpermeability via phosphorylation of VE-cadherins: Evidence from atomic force microscopy and biochemical studies. PLoS Neglected Tropical Diseases. 2012;6(6):e1699.
18. Cao AT, Yao S, Gong B, Elson CO, and Cong Y. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. Journal of Immunology 2012 Nov;189(9):4666-73. PMCID:PMC3478497.
19. Lihoradova OA, Indran SV, Kalveram B, Lokugamage N, Head JA, GONG B, Tigabu B, Juelich TL, Freiberg AN, Ikegami T. Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus. PLoS Neglected Tropical Diseases. 2012;7(4):e2181.PMCID: PMCID: PMC3630143.
20. Indran SV, Lihoradova OA, Phoenix I, Lokugamage N, Kalveram B, Head JA, Tigabu B, Smith JK, Zhang L, Juelich TL, GONG B, Freiberg AN, Ikegami T. Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains the neuroinvasiveness in mice. Journal of General Virology. 2013, Mar 20 (Epub ahead of print). PMID:23515022.
21. Saxena V, Xie G, Li B, Welte T, GONG B, Boor P, Wu P, Tang S, Tesh R, Wang T. A hamster-derived West Nile virus isolate induces persistent renal infection in mice.  PLoS Neglected Tropical Diseases. 2013;7(6):e2205.
22. GONG B (Corresponding author), Lee YS, Lee IH, Shelite T, Kunkeaw N, Xu G, Lee K, Jeon SH, Johnson B, Chang Q, Ha T, Mendell N, Cheng X, Bouyer D, Boor P, Ksiazek T, Walker DH. Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: Evidence of possible mediation by host tRNA-derived small noncoding RNAs. BMC Infectious Diseases 2013;13:285. PMID:23800282
23. Ren J, Kolli D, Deng J, Fang R, Xue M, GONG B, Casola A, Garofalo RP, Wang T, Bao X. MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis. Virus Research. 2013;176(1-2):241-50. PMID: 23845303.
24. GONG B (Corresponding author), Shelite T, Mei F, Ha T, Xu G, Chang Q, Hu Y, Wakamiya M, Ksiazek TG, Boor PJ, Bouyer D, Popov V, Chen J, Walker DH, Cheng X. Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. Proceedings of the National Academy of Sciences USA. 2013;110(48):19615-20.
25. Shelite T, Seito T, Mendell N, GONG B, Xu G, Soong L, Valbuena G, Bouyer D, Walker DH. A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus. PLoS Neglected Tropical Diseases. 2014;8(7): e2966. doi: 10.1371/journal.pntd.0002966.
26. Soong L, Wang H, Shelite T, Liang Y, Mendell N, Sun J, GONG B, Valbuena G, Bouyer D, Walker DH. Strong type 1, but impaired type 2, immune responses contribute to Orientia tsutsugamushi-induced pathology in mice. PLoS Neglected Tropical Diseases. 2014;8(9):e3191. doi:10.1371/journal.pntd.0003191
27. Cao A, Yao S, GONG B, Nurieva R, Elson C, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunology 2015; PMID: 25586558.

28. Ikegami T, Hill TE, Smith JK, Zhang L, Juelich TL, GONG B, Lihoradova O, Ly HJ,  Lokugamage N,  Freiberg AN. Rift Valley fever virus MP-12 vaccine is fully attenuated by a combination of S-, M- and L-segments. Journal of Virology. March 17, 2015;89(14):7262-76.

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