Education

Biography

Dr. Sayegh is a Professor of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University and Associate Dean for Research and Advanced Studies. He attended Baghdad University (Iraq, Veterinary Medicine), Kansas State University (MS), Purdue University (Equine Medicine and Surgery), University of Illinois at Urbana Champaign (Equine Medicine and Surgery) and Washington State University (PhD, Neuroscience). His research focuses on localizing the peripheral site(s) of action for gastrin releasing peptide (GRP) and cholecystokinin (CCK), which evoke reduction of meal size and prolongation of the intermeal interval, by delivering the peptides into specific regions in the gastrointestinal tract through (1) utilizing a microsurgical, intra-arterial catheterization technique, (2) analyzing the min-to-min behaviors that lead to feeding to determine meal sizes, intermeal interval and satiety ratio, (3) using a BioDAQ feeding system to record and analyze the feeding behavior of the rats in a freely-fed, undisturbed environment. In addition, we use immunohistochemical detection of neuronal markers and various surgical techniques e.g. vagotomy, sympathectomy and myotomy / myectomy to determine the possible neuronal pathways by which these peptide reduce meal size and prolong the intermeal interval. The work is funded by the NIH and various pharmaceutical companies.

Research Interest

Scientific Activities

Positions

Other Experience and Professional Memberships

Honors

Publications

1. Washington, M. C., Aglan, A. H. & Sayegh, A. I. (2014). The stomach and/or upper duodenum contain sites of action that control meal size and intermeal interval length by exogenous rat gastrin releasing peptide. Peptides 55C, 41-46.
2. Sayegh, A. I., Washington, M. C., Raboin, S. J., Aglan, A. H. & Reeve, J. J., Jr. (2014). CCK-58 prolongs the intermeal interval, whereas CCK-8 reduces this interval: Not all forms of cholecystokinin have equal bioactivity. Peptides.
3. Washington, M. C., Salyer, S., Aglan, A. H. & Sayegh, A. I. (2014). Intravenous infusion of gastrin-releasing peptide-27 and bombesin in rats reveals differential effects on meal size and intermeal interval length. Peptides 51, 145-9.
4. Sayegh, A. I. (2013). The role of cholecystokinin receptors in the short-term control of food intake. Prog Mol Biol Transl Sci 114, 277-316.
5. Sayegh, A. I. (2013). The role of bombesin and bombesin-related peptides in the short-term control of food intake. Prog Mol Biol Transl Sci 114, 343-70.
6. Wright, S. A., Washington, M. C., Garcia, C. & Sayegh, A. I. (2012). Gastrin releasing peptide-29 requires vagal and splanchnic neurons to evoke satiation and satiety. Peptides 33, 125-31.
7. Hunt, J. V., Washington, M. C. & Sayegh, A. I. (2012). Exenatide and feeding: possible peripheral neuronal pathways. Peptides 33, 285-90.
8. Washington, M. C. & Sayegh, A. I. (2011). Gastrin releasing peptides increase Fos-like immunoreactivity in the enteric nervous system and the dorsal vagal complex. Peptides 32, 1600-5.
9. Washington, M. C., Coggeshall, J. & Sayegh, A. I. (2011). Cholecystokinin-33 inhibits meal size and prolongs the subsequent intermeal interval. Peptides 32, 971-7.
10. Metcalf, S. A., Washington, M. C., Brown, T. A., Williams, C. S., Strader, A. D. & Sayegh, A. I. (2011). Ileal interposition attenuates the satiety responses evoked by cholecystokinin-8 and -33. Peptides 32, 1296-302.