Education

Degree	Discipline	Year	Institute
PhD	Microbiology	1984	University of Kansas
Postdoctoral Training	Viral Carcinogenesis	June,1984 - May,1987	Linus Pauling Institute of Science and Medicine

 

Biography

Dr. Clinton Jones is working as a Professor of veterinary pathobiology, Oklahoma state University. He completed his PhD from Linus Pauling Institute of Science and Medicine (Palo Alto, CA) Laboratory of Viral Carcinogenesis, June, 1984-May, 1987. Dr. Clinton Jones has published more than 100 articles and is the author of many books. His research interest mainly focused on Latency of α-herpesvirinae subfamily members apart from two α-herpesvirinae subfamily members, Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1). His contribution has made it significant in understanding the latency-reactivation cycle of BHV-1 and HSV-1, and the similarities of these two distinct viruses have in common during the latency-reactivation cycle. Few of the recent discoveries of Dr. Jones include the identification of cellular transcription factors in sensory neurons of trigeminal ganglia that are induced by the synthetic corticosteroid dexamethasone during BHV-1 and HSV-1 reactivation from latency.

 

Research Interest

Latency of α-herpesvirinae subfamily members continues to be a major focus of my research program.  Two α-herpesvirinae subfamily members, Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1), are being studied. In contrast to the 70-80 viral genes expressed during productive infection, viral gene expression is restricted to the BHV-1 latency related (LR) gene or the HSV-1 latency-associated transcript (LAT) during latency.  My laboratory has made significant contributions to our understanding of the latency-reactivation cycle of BHV-1 and HSV-1, and the similarities these two distinct viruses have in common during the latency-reactivation cycle. For example, we demonstrated that LAT and the LR gene inhibit apoptosis   and productive infection, which promotes survival of infected neurons.  Although LAT and the LR gene have similar functions, their mechanisms of action are quite distinct. For example, the BHV-1 LR gene encodes a protein (ORF2) that inhibits apoptosis whereas LAT encodes 2 small non-coding RNAs that inhibit apoptosis in the   absence of other viral genes.  The 2 LAT small non-coding RNAs are not micro- RNAs but they are encoded within LAT sequences that are important for reactivation from latency, which suggests they are important for reactivation from latency.

LAT and LR gene products also promote neurite sprouting in neuroblastoma cells, which correlates with a mature neuronal phenotype.  We have not identified the LAT products that are important for neurite formation.  ORF2 interferes with Notch signaling and promotes neurite formation and neuronal differentiation in the presence of Notch1 or Notch3.  The ability of ORF2 to directly bind Notch1 and Notch3 is important for this function.  During mammalian embryogenesis, Notch family members prevent neuronal differentiation by inhibiting axon development; consequently Notch signaling maintains a pool of neuro-progenitors.  Notch3 expression and Notch signaling is stimulated during dexamethasone induced BHV-1 reactivation from latency indicating there is a need to block Notch signaling to maintain a differentiated neuronal phenotype.

Recent studies have identified cellular transcription factors in sensory neurons of trigeminal ganglia that are induced by the synthetic corticosteroid dexamethasone during BHV-1 and HSV-1 reactivation from latency.  A subset of these stress-induced transcription factors stimulate certain BHV-1 and HSV-1 promoters, in particular the ICP0 promoters of both viruses.

In addition to the latency-reactivation cycle of α-herpesvirinae subfamily members, my laboratory has contributed to our understanding of innate and immune responses to viral infection.  For example, we have demonstrated that BHV-1 encoded infected cell protein 0 (bICP0) interferes with beta-interferon signaling by degrading a transcription factor required for activating the beta-interferon promoter (IRF3).  IRF7, also important for trans-activating the beta-interferon promoter, is sequestered and inactivated by bICP0.  Although every ICP0 encoded by a α-herpesvirinae subfamily member interferes with beta-interferon production, each ICP0 has its own  mechanism of action.

 

Research Overview

USDA, NIFA, Analysis of Bovine Herpesvirus 1 stress induced reactivation from latency. 10/1/2013-9/30/2017, $500,000. The goals of this grant are to identify viral and cellular genes that are stimulated during the early stages of stress-induced reactivation from latency.

Grants

1. Boehringer Ingelheim Vetmedica: 5/22/20 5-22/21/2014: $98,0000, Vaccine development.
2. Nebraska Research Initiative: 7/1/2012-6/31/2014: $100,000, Dynamics of acquisition and transmission of poly-microbial respiratory disease that affect cattle: Bovine respiratory disease complex (BRDC).
3. Nebraska Center for Virology: 6/1/2012-12/30/2014: $100,000, Regulation of HSV-1 infection by nucleic acid sensors.
4. National Cancer Institute. Mechanistic Approaches to HSV-2 Induced Transformation, 7/1/88- 6/30/93, $450,000.
5. Nebraska Department of Health, Analysis of Tumor Promoter Induced Transcription, 7/90- 7/92, $70,000.
6. Center for Biotechnology, Analysis of Tumor Promoter Induced Transcription, 7/90- 7/92, $30,000.
7. Center for Biotechnology, UNL. Equipment grant to purchase Phosphorimager. 7/1/93, $50,000.
8. USDA (92-34103-7168). Is the latency related gene of BHV-1 necessary for a latent infection of cattle? 4/15/92-4/30/95, $100,000.
9. USDA: National Research Initiative Competitive Grants Program (NRICGP) (92-03562). Regulation of Bovine Herpesvirus 1 Transcription during a Latent Infection. 10/1/92-9/30/94, $100,000.
10. Center for Biotechnology, UNL. Molecular Analysis of the Tumor Promoter Pristane. 7/1/92- 6/30/94, $24,000.
11. Nebraska Department of Health, The role of HSV-2 as a cofactor in cervical cancer. 7/93 -7/95,  $60,000.
12. Center for Biotechnology, UNL. Equipment grant to purchase Avanti centrifuge. 7/1/95, $30,000.
13. USDA: NRICGP (94021117). Analysis of the Bovine Herpesvirus 1 Latency Related Gene. 10/1/94-9/30/97, $219,627.
14. USDA: NRICGP (9502236). Analysis of BHV-1 gene expression during reactivation from latency. 10/95-9/98, $167,620.
15. USDA: PI: Martin Dickman, co-PI: Clinton Jones. Molecular Mechanism of Fumonisin Induced Pathogenesis in Chickens. 9/1/96-8/30/98, $120,000.
16. Pfizer, Analysis of latency by a thermosensitive vaccine strain of bovine herpesvirus 1 in cattle. $120,000.
17. Elsa E. Pardee Foundation, Identification of genes that are regulated by Fumonisin B1, a carcinogen that is a contaminant of corn and other cereal grains. 12/99-12/00, $60,000.
18. USDA: NRICGP (9702394). Analysis of Bovine Herpesvirus 1 Latency Related Gene. 9/97-9/2000, $248,452.
19. USDA, National Research Initiative Competitive Grants Program (9802213). Analysis of Apoptosis and Pathogenesis by Bovine Herpesvirus 1 and bICP0. 10/1/1998-9/30/2001, $319,600).
20. USDA, National Research Initiative Competitive Grants Program (2000-2003). Inhibition of apoptosis by the Bovine Herpesvirus 1 (BHV-1) Latency Related Gene Products. 10/1/2000-9/30/2003, $292,000.
21. NIH supplement to purchase Biorad Image Analyzer, $120,000, 2004.
22. USDA, National Research Initiative Competitive Grants Program. Functional analysis of bICP0, a BHV-1 gene that is a promiscuous trans-activator. 9/1/2002-8/30/2005, $300,000.
23. Pfizer, Analysis of BHV-1 present in aborted fetuses, $60,000. Recent outbreaks of BHV-1 occurred in certain breeding stock following vaccination. 10/01/04-9/30/05.
24. COBRE NIH grant, 2000-2005. Each year I received $100,000 direct costs/year for my project from this grant. My project was entitled Functional analysis of alpha-herpesvirus latency associated transcripts. Essentially, this was a program project grant given to the Nebraska Center for Virology.
25. USDA, National Research Initiative Competitive Grants Program. Regulation of the latency-reactivation cycle by the Bovine Herpesvirus 1 (BHV-1) Latency Related Gene, 11/1/2003 to 10/30/2006, $320,000. The mechanism by which the BHV-1 gene regulates latency and prevents programmed cell death (apoptosis) was examined.
26. Fort Dodge Animal Health, Stability of the LR mutant virus in cattle. $65,000.
27. USDA, National Research Initiative Competitive Grants Program. Functional analysis of bICP0, a BHV-1 gene that is a promiscuous trans-activator. 9/1/52005-8/30/2008, $350,000.
28. USDA, National Research Initiative Competitive Grants Program. Functional analysis of proteins encoded by the BHV-1 latency related gene. 9/15/06-9/14/09, $374,585.
29. NIH (R21AI069176), Does the HSV-1 latency associated transcript (LAT) encode a protein? 7/5/07-7/4/10, $401,500. The goals of this grant were to identify proteins encoded by LAT, and test whether these proteins inhibit apoptosis.
30. USDA, National Research Initiative Competitive Grants Program. Functional analysis of bICP0, a BHV-1 gene that stimulates productive infection. 9/1//2008-8/30/2011, $375,000. The goals of this grant were to test whether bICP0 regulates chromatinization of the viral genome, identify protein domains in bICP0 that regulate interferon dependent transcription, and characterize a bICP0 zinc RING finger mutant.
31. USDA, NIFA, Analysis of viral factors that regulate the bovine herpesvirus 1 latency reactivation cycle. 10/01/09-9/30/13, $375,000. The goals of this grant are to test whether a protein encoded by the BHV-1 LR (latency related) gene controls the latency-reactivation cycle. Additional studies will identify and characterize a micro-RNA encoded within the LR gene.

Professional Activities:

Previous Academic Appointments:

• Assistant  Professor,  Department  of  Microbiology,  University  of  Mississippi  Medical  Center (Jackson, MS) May, 1987-October, 1989.
• Associate Professor:  October 1, 1989 University of Nebraska-Lincoln (October 1, 1989)
• Professor:  School of Biological Sciences, University of Nebraska, Lincoln 1996-Present

Adjunct Appointments:

• Department of Pathology and Microbiology, University of Nebraska Medical Center

Professional Memberships

• American Society of Microbiology
• International Society of Neurovirology
• American Society for Virology
• American Association for the Advancement of Science

 

Teaching

2016-Present	Sitlington Professor	Department of Veterinary Pathobiology	Oklahoma State University
2001-2015	Professor	Department of Veterinary and Biomedical Sciences	University of Nebraska, Lincoln
1996-2001	Professor	Department of Veterinary and Biomedical Sciences	University of Nebraska, Lincoln
1989-1995	Associate Professor	Department of Veterinary Sciences	University of Nebraska-Lincoln
1987-1989	Assistant  Professor	Department  of  Microbiology	University  of  Mississippi  Medical  Center

Awards and Honors

1. Panel Manager for USDA Study Section (1996, 2001, 2004, and 2006)
2. Panel Member for USDA Study Section (1993, 1998, and 2011)
3. Outstanding Researcher, Gamma Sigma Delta (Honor Society of Agriculture), 2010
4. Study Section member for NIH, National Institute of Allergy and Infectious Diseases
5. (NIAID) Reviewed program project grants in 2010, 2011, 2012, and 2013.
6. Ad-Hoc Reviewer for NIH (2001 and 2003)

Publications

1. Kook, I., A. Doster, and C. Jones.  Bovine herpesvirus 1 regulatory proteins are detected in trigeminal ganglionic neurons during the early stages of stress-induced escape from latency.
2. Sinani, D., Y. Liu, and C. Jones. 2014. Analysis of a  bovine  herpesvirus  1  protein encoded by an alternatively spliced latency related (LR) RNA that is abundantly expressed in latently infected neurons.  Virology, 465:244-252.
3. Jamin, A., P. Thunuguntla, A. Wicklund, C. Jones, and M.S. Wiebe. Barrier to Autointegration Factor Becomes Dephosphorylated During HSV-1 Infection and Can Act as a Host Defense by Impairing Viral DNA Replication and Gene Expression. 2014. PLOS One, 9: e100511.
4. Mott, K.R., S.J. Allen, M. Zandian, B. Konda, B.G. Sharifi, C. Jones, S.L. Wechsler, D. Littman, T. Town, and H. Ghiasi.  2014.  CD8α+ dendritic cells contribute to increased HSV-1 latency in trigeminal ganglia of latently infected mice. PLOS One, 9: e93444.
5. Wang, J., Alexander, M. Wiebe, and C. Jones. 2014. Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity. Virus Research, 185: 72- 76.
6. Allen, S.J., K,R. Mott, A. Rhode-Kurnow, X. Jiang, D. Carpenter, C.F. Ware, C. Jones, S.L. Wechsler, and H. Ghiasi.  2014.  Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript (LAT) during HSV-1 Latency. J of Virology, 88: 1961-1971.
7. Devis Sinani, Ethan Cordes, Aspen Workman, Prasanth Thunuguntia, and Clinton Jones. 2013. Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) promoter. J of Virology,  87:1183-1192.
8. Frizzo da Silva, L. I. Kook, A. Doster, and  C.  Jones.  2013.  Bovine  herpesvirus  1 regulatory proteins, bICP0 and VP16, are readily detected in trigeminal ganglionic neurons expressing the glucocorticoid receptor during the early stages of reactivation from latency. J of Virology, 87: 11214-11222.
9. Frizzo da Silva, L. and C. Jones.  2013.  Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival. Virus Research, 175:101-109.
10. Pittayakhajonwut, D., D. Sinani, and C. Jones.  2013.  A protein (ORF2) encoded by the latency related gene of bovine herpesvirus 1 interacts with DNA. J of Virology, 87: 5943-5501.
11. Sinani, D., L. Frizzo da Silva, and C. Jones.  2013.  A bovine herpesvirus 1 protein expressed in latently infected neurons (ORF2) promotes neurite sprouting in the presence of activated Notch1 or Notch3. J of Virology, 87:1183-1192.
12. Frizzo da Silva, L., D. Sinani, and C. Jones. 2012.  The ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-β1) and IFN-β3.  Virus Research, 169:162-168.
13. Workman, A., J. Eudy, L. Smith, L. Frizzo da Silva, D. Sinani, H. Bricker, E. Cook, A. Doster, and C. Jones.  2012.  Cellular transcription factors induced in trigeminal ganglia during dexamethasone-induced reactivation from latency stimulate bovine herpesvirus 1 productive infection and certain viral promoters. J Virol 86: 2459-2473.
14. Frizzo da Silva, L.F. and C. Jones. 2012.  Two micro-RNAs encoded within the BHV-1 latency related (LR) gene promote cell survival by interacting with RIG-I and stimulating nuclear factor-kappa B (NF-kB) dependent transcription and beta-interferon signaling pathways.  J Virol, 86:1670-1682.
15. Sinani, D. and C. Jones.  2011.  Localization of sequences in a protein encoded by the latency related gene of bovine herpesvirus 1 (ORF2) that inhibits apoptosis and interferes with Notch1 mediated trans-activation of the bICP0 promoter. J Virol 85: 12124-12133.
16. Chowdhury, S.I., M.C.S. Brum, C. Coats, A. Doster, H. Wei, C. Jones. 2011. Bovine Herpesvirus Type 1 envelope protein Us9 acidic domain is crucial for anterograde axonal transport.  Vet Micro 28:270-279.
17. Frizzo da Silva, L.F., N. Gaudreault, and C. Jones. 2011. Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits beta interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels. Virus Research 169:143-149.
18. Workman, A. and C. Jones.  2011.  Analysis of the cell cycle regulatory protein (E2F1)  after infection of cultured cells with bovine herpesvirus 1 (BHV-1) or herpes simplex virus type 1 (HSV-1).  Virus Research 160: 66-73.
19. Frizzo da Silva, L. and C. Jones. 2011. Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes. Virus Research, 157: 54-60.       
20. Allen, S.J., P. Hamrah, D.M. Gate, K.R. Mott, D. Mantopoulos, L. Zheng, T. Town, C. Jones, U. H. von Andrias ,G.J. Freeman, A.H. Sharpe, L. BenMohamed, R. Ahmed, S.L. Wechsler, and H. Ghiasi.  2011. The role of LAT in increased CD8+ T cell exhaustion 1 in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.  J Virol, 85:4184- 4197.
21. Gaudreault, N. and C. Jones. 2011. Regulation of promyelocytic leukemia (PML) protein levels and cell morphology by bovine herpesvirus 1 infected cell  protein  0 (bICP0) and mutant bICP0 proteins that do not localize to the nucleus. Virus Research, 156:17-24.
22. Jiang, X., A. Chentoufi , C. Hsiang, D. Carpenter, N. Osorio, L. BenMohamed, N.W. Fraser, C. Jones, and S.L. Wechsler.  2011.  The herpes simplex virus type 1 latency associated transcript (LAT) can protect cells from Granzyme B induced apoptosis and CD8 T- cell killing. J Virology 85:2325-2332.
23. Workman, A., D. Sinani, D. Pittayakhajonwut, and C. Jones.  2011.  A Protein (ORF2) Encoded by the Latency Related Gene of Bovine Herpesvirus 1 Interacts with Notch1 and Notch3. J Virology, 85: 2536-2546.
24. Workman, A. and C. Jones. Bovine herpesvirus 1 (BoHV1) productive infection and bICP0 early promoter activity are stimulated by E2F1. 2010. J Virology, 84: 6308– 6317.
25. Jaber, T., A. Workman, and C. Jones. Small non-coding RNAs encoded within the bovine herpesvirus 1 latency related gene can reduce steady state levels of infected cell protein 0 (bICP0).  2010.  J Virology, 84: 6297–6307
26. Li, S.,  D. Carpenter, C. Hsiang, S.L. Wechsler, and C. Jones. 2010.  The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels. J General Virology 91:858-866.
27. Beura  L.K.,  S.N.  Sarkar,  B.J.  Kwon,  S.  Subramaniam,  C.  Jones,  A.K.  Pattnaik,  F.A. Osorio. 2010. Porcine reproductive and respiratory syndrome virus non-structural protein 1a modulates host innate immune response by antagonizing IRF3 activation. J. Virology, 84: 1574- 1584.
28. Henderson, G., T. Jaber, D. Carpenter, S.L. Wechsler, and C. Jones.  2009.  Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript.  J. of Neurovirology, 15: 479-488.
29. Ellis, J., S. Gow, N. Goji, C. Jones, A. Workman, G. Henderson, G. Alaniz, and T. Meinert. 2009. Efficacy of a combination viral vaccine in protecting cattle from experimental infection with bovine herpesviruses-1 isolated from recent “vaccine breaks”. J of American  Veterinary Medical Association, 235:563-572.
30. Shen, S., M. Sa e Silva, T. Jaber, O. Vitvitskaia, S. Li, G. Henderson, and C. Jones. 2009. Two small RNAs encoded within the first 1.5 kb of the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) can inhibit productive infection, and cooperate to inhibit apoptosis.  J. Virology, 83: 9131-9139.
31. Jaber, T., G. Henderson, S. Li, G.-C. Perng, D. Carpenter, S. Wechsler, and C. Jones. 2009. Identification of a novel herpes simplex virus type 1 (HSV-1) transcript and protein (AL3) expressed during latency.  J. Gen. Virology, 90: 2342 - 2352.  
32. Workman, A., S. Perez, A. Doster, and C. Jones. 2009. Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 (BHV-1) leads to activation of the bICP0 early promoter, in part by the cellular transcription factor C/EBP-alpha. J. Virology, 83:8800-8809.
33. Meyer, F. and C. Jones. 2009. C/EBP-alpha cooperates with bTIF to activate the bovine herpesvirus 1 immediate early transcription unit 1 promoter.  J. Neurovirology 15:123-130.
34. Saira, K., Y. Zhou, and C. Jones.  2009.  The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 (IRF7), and consequently inhibits beta interferon promoter activity.  J. Virology. 83:3977-3981.
35. Brum. M.C.S., C. Coats, B.R. Sangena, A. Doster, C. Jones, and S.I. Chowdhury.  2009. Bovine herpesvirus type 1 (BoHV-1) anterograde neuronal transport from trigeminal ganglia to nose and eye requires glycoprotein E.  J. Neurovirology, 15:1-6.
36. Carpenter, D., S. Singh, N. Osorio, C. H., X. Jiang, L. Jin, C. Jones, and S.L. Wechsler. Mutation of a putative ribozyme site in the herpes simplex virus type 1 gene that encodes LAT does not decrease the viral reactivation phenotype.  2008.  J. Neurovirology,  14:558-562.
37. Jin, L., D. Carpenter, M. Moerdyk-Schauwecker, A.L. Vanarsdall, N. Osorio, C. Hsiang, C. Jones, and S.L. Wechsler.  2008.  Cellular FLIP can substitute for the herpes simplex virus type 1 LAT gene to support a wild type virus reactivation phenotype in mice. J. Neurovirology, 14:389-400.
38. Saira, K., S. Chowdhury, N. Gaudreault, L. da Silva, G. Henderson, A. Doster, & C. Jones. 2008. The zinc RING finger of the bovine herpesvirus 1 encoded bICP0 protein is crucial for viral replication and virulence.  J. Virology, 82:12060-12068.
39. Shen, W. and C. Jones. 2008.  Open reading frame 2 encoded by the latency related gene of bovine herpesvirus 1 has anti-apoptosis activity  in  transiently  transfected  neuroblastoma cells. J. Virology, 82:10940-10945.
40. Liu. Z.F.,  M.C.S. Brum,  A. Doster, C. Jones, and  S.I. Chowdhury.  2008.  A Bovine Herpesvirus Type 1 (BHV-1) Mutant Virus Specifying a Carboxyl Terminal Truncation of Glycoprotein E (gE) is Defective in Anterograde Neuronal Transport in Rabbits and Calves.  J. Virology,  82:7432-7442.
41. Geiser, V., S. Rose, and C. Jones.  2008.  Bovine herpesvirus type 1 induces cell death by a cell type dependent fashion.  Microbial Pathogenesis 44:459-466.
42. Perez, S., F. Meyer, K. Saira, A. Doster, and C. Jones. 2008. Premature expression of the latency-related  (LR)  RNA  correlates  with  higher  levels  of  beta-interferon  RNA  expression  in productively infected cells.  J. Gen. Virology 89: 1338 - 1345.
43. Peng, W., O. Vitvitskaia, D. Carpenter, S.L. Wechsler, and C. Jones.  2008.   Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1 (HSV-1) encoded latency-associated transcript (LAT).  J Neurovirology, 14:41-52.
44. Papugani, A.,  T. Coleman, C. Jones, and L. Zhang.  2008. The interaction between KSHV RTA and cellular RBP-Jk and their subsequent DNA binding are not sufficient for activation of RBP-Jκ. Virus  Research, 131: 1-7.
45. Meyer, F., S. Perez, Y. Jiang, Y. Zhou, G. Henderson, and C. Jones. 2007.  Identification of a novel protein encoded by the latency related (LR) gene of bovine herpesvirus 1 (BHV-1). J Neurovirology,  13:569-578.
46. Carpenter, D., G. Henderson, C. Hsiang, N. Osorio, L. BenMohamed, C. Jones, and S. L. Wechsler. 2007.  Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity.   Microbial Pathogenesis, 44:98-102.
47. Carpenter, D.,  C. Hsiang, L. Jin, N. Osorio, L. BenMohamed, C. Jones, and S.L. Wechsler. 2007.  Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis. Virology, 369:12-18.
48. Butchi, N.B., C. Jones, S.Perez, A.Doster, and S.I.Chowdhury. 2007. Envelope glycoprotein Us9 is required for the anterograde transport of Bovine herpesvirus-1 (BHV-1) from trigeminal ganglia to nose upon reactivation. J Neurovirology, 13:384-388.
49. Xu, D., J. Zhang, T. Coleman, A. Fagot, C. Kotalik, L. Zhao, C. Jones, and L. Zhang.  2007. A regulatory loop between Kaposi’s sarcoma-associated herpesvirus replication and  transcription activator (RTA) and Epstein-Barr virus latent membrane protein 1 (LMP-1).  J Virology  81:6068-6078.
50. Jin, L., G.-C. Perng, D. Carpenter, K. R. Mott, N. Osorio, J. Naito, D.J. Brick, C. Jones, and S.L. Wechsler . 2007. Reactivation Phenotype in Rabbits of a Herpes Simplex Virus Type 1 (HSV-1) Mutant Containing an Unrelated Anti-Apoptosis Gene in Place of LAT. J Neurovirol 13: 78-84.
51. Perez, S., F. Meyer, G. Henderson, Y. Jiang, S. Sherman, A. Doster, M. Inman, and C. Jones.  2007.  A protein encoded by the bovine herpesvirus 1 ORF E gene induces neurite-like morphological changes in mouse neuroblastoma cells and is expressed in trigeminal ganglionic neurons.  J Neurovirol, 13:139–149.
52. Saira, K. and C. Jones.  2007.  The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 (IRF3), and consequently inhibits beta interferon promoter activity. J Virology 81:3077-3086.
53. Horiba, M., L.B. Martinez, J.L. Buescher, S. Sato, J. Limoges, J. Jiang, C. Jones, and T. Ikezu. 2007. OTK18, a zinc finger protein, regulates HIV LTR through two distinct regulatory regions.  J Gen Virol, 88:236-241.
54. Meyer, F., S. Perez, V. Geiser, M. Sintek, M. Inman, & C. Jones. 2007.  A protein encoded by the bovine herpes virus 1 (BHV-1) latency related gene interacts with specific cellular regulatory proteins, including the CCAAT enhancer binding protein alpha (C/EBP-α). J Virol 81:59-67.
55. Perez, S. L. Lovato, J. Zhou, A. Doster & C. Jones. 2006. Comparison of inflammatory infiltrates in trigeminal ganglia of cattle infected with wild type BHV-1 versus a virus strain containing a mutation in the LR (latency-related) gene.  J Neurovirol, 12:392-397.
56. Morishige, N.,  J.V. Jester, J. Naito, N. Osorio, A. Wahlert,  C. Jones, R.D. Everett, S.L. Wechsler, and G. C. Perng.  2006.  HSV-1 ICP0 localizes in the stromal layer of infected rabbit corneas and predominantly resides in the cytoplasm and/or perinuclear region of rabbit keratocytes.  J Gen Virol  87:2817-2825.
57. Chan, D., J. Cohen, J. Naito, K.R. Mott, N. Osorio, L. Jin, N.W. Fraser, C. Jones, S.L. Wechsler, and G. Chuen Perng. 2006. A mutant deleted for most of the herpes simplex virus type 1 (HSV-1) UOL gene does not affect the spontaneous reactivation phenotype in rabbits. J Neurovirol 12:5-16.
58. Geiser, V. and C. Jones. 2005.  Localization of sequences within the latency related gene of bovine herpesvirus 1 that inhibit mammalian cell growth. J Neurovirol 11:563-570.
59. Jones, C., M. Inman, W.  Peng, G. Henderson, A. Doster, G.-C. Perng, and A. Kaenjak Angeletti. 2005. The herpes simplex virus type 1 (HSV-1) locus that encodes the latency- associated transcript (LAT) enhances the frequency of encephalitis in male Balb/C mice. J Virol 79:14465-14469.
60. Jin, L., G.-C. Perng, K.R. Mott, N. Osorio,, J. Naito, D.J. Brick, D. Carpenter, C. Jones, and S.L. Wechsler.  2005.  A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene (cpIAP) in place of LAT (Latency Associated Transcript) has a wild type reactivation phenotype in the mouse.  J Virol 79:12286–12295.
61. Henderson, G., Y. Zhang, and C. Jones.  2005.  The bovine herpesvirus 1 (BHV-1) gene encoding infected cell protein 0 (bICP0) can inhibit interferon dependent transcription in the absence of other viral genes. J G Virology 86: 2697-2702.
62. Geiser, V., Y. Zhang, & C. Jones.   2005.   Analysis of a bovine herpesvirus 1 (BHV-1) recombinant virus that does not express the bICP0 protein. J Gen Virol 86:1987-1996.
63. Peng, W., G. Henderson, M. Inman, L. BenMohamed, G.-C. Perng, S. L. Wechsler, and Clinton Jones.  2005.  The locus encompassing the latency-associated transcript (LAT) of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal ganglia of acutely infected mice. J Virol 79:6162- 6171.
64. Barsam, C.A, DJ. Brick, C Jones, SL Wechsler, G-C Perng. 2005. A viral model for corneal scarring and neovascularization following ocular infection of rabbit with a  herpes simplex virus type 1 (HSV-1) mutant. Cornea 24:460-466.
65. Zhang, Y. and C. Jones.  2005.  Identification of functional domains within the bICP0 protein encoded by bovine herpesvirus 1 (BHV-1).  J Gen Virol 86:879-886.
66. Perez, S., M. Inman, A. Doster, and C. Jones. 2005. The latency related gene encoded by bovine herpesvirus 1 (BHV-1) promotes virus growth and reactivation from latency in tonsils of infected calves.  J Clin Micro. 43: 393-401.
67. Peng, W., L. Jin, G. Henderson, G.C. Perng, D.J. Brick, A.B. Nesburn, S.J. Wechsler, and C. Jones.   2004.   Mapping herpes simplex virus type 1 (HSV-1) LAT sequences that protect from apoptosis mediated by a plasmid expressing caspase-8.  J Neurovirol 10:260-265.
68. Henderson, G., Y. Zhang, M. Inman, D. Jones and C. Jones.  2004.  Infected cell protein 0 encoded by bovine herpesvirus 1 can activate caspase 3 when overexpressed in transfected cells.  J Gen Virol 85: 3511-3516.
69. Jin, L., GC Perng, DJ Brick, J Naito, AB Nesburn, C Jones, and SL Wechsler.  2004. Methods for detecting the HSV-1 LAT anti-apoptosis activity in Infected Tissue Culture cells.  J Virol Meth 118:9-13.
70. Inman, M., J. Zhou, H. Webb, and C. Jones. 2004. Identification of a novel transcript containing a small open reading frame that is expressed during latency, and is antisense to the latency related gene of bovine herpes virus 1 (BHV-1).  J Virol 78:5438-5447.
71. Jiang, Y., M. Inman, Y. Zhang, N. A. Posadas , and C. Jones. 2004. A mutation in the latency related gene of bovine herpesvirus 1 (BHV-1) inhibits expression of proteins encoded by ORF2 and Reading Frame C during productive infection.   J Virol 78:3184-3189.
72. Henderson, G., G.-C. Perng, A. B. Nesburn, S. L. Wechsler, and C. Jones. 2004. The latency related (LR) gene encoded by bovine herpesvirus 1 (BHV-1) can suppress caspase 3 and caspase 9 cleavage during productive infection.  J  Neurovirol 10:64-70.
73. Devireddy, L., Y. Zhang, and C. Jones. 2003. Cloning and initial characterization of an alternatively spliced transcript encoded by the bovine herpes virus 1 latency related (LR) gene. J Neurovirol 9: 612-622.
74. Peng, W. G. Henderson, G.-C Perng, A.B. Nesburn, S.L. Wechsler, and C. Jones. 2003. The gene that encodes the herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) influences the accumulation of the transcripts (Bcl-xL and Bcl-xS), that encode apoptotic regulatory proteins.  J Virol 77:10714-10718.
75. Mott, K.,  N. Osorio, L. Jin, D. Brick, J. Naito, J. Cooper, G. Henderson, M. Inman, C.  Jones, S. L. Wechsler, and G.-C. Perng.  2003.  The bovine herepsvirus-1 LR ORF-2 is crucial for this gene’s ability to restore the high reactivation phenotype to an HSV-1 LAT null mutant.  J Gen Virol 84:2975-2985.
76. Jin, L.,  W. Peng,  G-C Perng,  A.B. Nesburn,  C. Jones, and S.L. Wechsler.  2003. Identification of herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype.  J Virol 77:6556-6561.
77. Geiser, V. and C. Jones. 2003. Stimulation of bovine herpesvirus 1 productive infection by the adenovirus E1A gene and the cellular transcription factor E2F4.  J Gen Virol 84:929-938.
78. Lovato, L.,  M.  Inman,  G.  Henderson,  A.  Doster., and C. Jones, C.  2003.  Infection of cattle with a bovine herpesvirus 1 (BHV-1) strain that contains a mutation in the latency related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency. J Virol 77:4848-4857.
79. Geiser, G., M. Inman, Y. Zhang, and C. Jones. 2002. The latency related (LR) gene of bovine herpes virus 1 (BHV-1) can inhibit the ability of bICP0 to activate productive infection. J Gen Virol 83: 2965 - 2971.
80. Henderson, G., W. Peng, L. Jin, G.-C. Perng, A.B. Nesburn, S.L. Wechsler, and C. Jones. 2002. Regulation of caspase 8-and caspase 9-induced apoptosis by the HSV-1 latency associated transcript.  J Neurovirol 8 (suppl 2) 103-111.
81. Perng,G.-C., B. Maguen, L. Jin, K.R. Mott, S.M. Slanina, A. Yukht, H. Ghiasi, N. Osorio, H.K. Hamdi, A.B. Nesburn, G. Henderson, M. Inman, C. Jones, and S.L. Wechsler. 2002. A novel herpes simplex virus type 1 (HSV-1) transcript (AL-RNA) antisense to the 5’ end of LAT (latency) associated transcript) produces a protein in infected rabbits.  J Virol 76:8003-8010.
82. Inman, M.,  L. Lovato, A. Doster, and C. Jones.  2002.  A mutation in the latency related gene of bovine herpesvirus 1 disrupts the latency-reactivation cycle in calves.  J Virol 76:6771- 6779.
83. Winkler, M.T.C., A. Doster, J-H. Sur, and C. Jones. 2002. Analysis of bovine trigeminal ganglia following infection with bovine herpesvirus Vet Microb, 86:139-155.
84. Perng, G.-C., B. Maguen, L. Jing, K.R. Mott, N. Osorio, S.M. Slanina, A. Yukht, H. Ghiasi, A.B. Nesburn, M. Inman, G. Henderson, C. Jones, and S.L. Wechsler.  2002.   A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 LAT gene and restore wild type reactivation levels. J Virol 76:1224-1235.
85. Zhang, Y. and C. Jones.  2001.  The bovine herpes virus 1 immediate early protein (bICP0) is associated with histone deaetylase 1 to activate transcription.  2001.  J Virol 75:9571-9578.
86. Inman, M.,  L. Lovato,  A. Doster,  and C. Jones.  2001.  A mutation in the latency related gene of bovine herpesvirus 1 leads to impaired ocular shedding in acutely infected calves.  J Virol 75:8507-8515.
87. Inman, M., G.-C. Perng, G. Henderson, A. B. Nesburn, and S. L. Wechsler, and C. Jones. 2001.  Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture.  J Virol. 75:3636-3646.
88. Inman, M., Y. Zhange, V. Geiser, and C. Jones. 2001. The zinc ring finger of bovine herpes virus 1 encoded bICP0 is necessary for transcriptional regulation and infection. J Gen Virol 82:483-492.
89. Jones, C.,  J.R. Ciacci-Zanella, Y. Zhang, G. Henderson, and M. Dickman. 2001.  Analysis of Fumonisin B1 Induced Apoptosis.  Env Health Persp  39:45-53.
90. Zhang, Y., C. Jones, and M.B. Dickman. 2001. Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B1. Food Chem Toxicol 39:45-53.
91. Hinkley, S.,   A.P.N. Ambagala, C. Jones, and S, Srikumaran.   2000.   A vhs-like activity of bovine herpesvirus-1.  Arch Virol 145:2027-2046.
92. M. T. Winkler,  Holt, T.,  A. Hossain,  A. Doster,  L. Schang, and C. Jones.  2000. Expression of cyclin D1, E, and A in trigeminal ganglionic neurons after infection with bovine herpes virus 1.  J Gen Virol  81:2993-2998.
93. Jones, C., T.J. Newby, T. Holt, A. Doster, M. Stone,  J. Ciacci-Zanella, C.J. Webster, and M. W. Jackwood.  2000.  Analysis of latency in cattle after inoculation with a temperature sensitive mutant of bovine herpevirus 1 (RLB106).  Vaccine 18:3185-3195.
94. Winkler, M.T.,  A. Doster, and C. Jones.  2000.  Persistence and reactivation of BHV-1 in tonsils of latently infected cattle.  J Virol 74:5337-5346.
95. Perng, G.-C.,  C. Jones, J. Ciacci-Zanella, M. Stone, G. Henderson,  A. Yukht, S.M. Slanina,  F.M. Hoffman, H. Ghiasi, A.B. Nesburn, S. Wechsler.  2000.  Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript (LAT).  Science 287:1500-1503.
96. Devireddy,  L.  and  C.  Jones.        2000.     Olf-1,  a  neuron-specific  transcription  factor,  can activate the herpes simplex virus 1 ICP0 promoter. J Biol Chem 275:77-81.
97. Ciacci-Zanella, J. M. Stone, G. Henderson, and C. Jones.  1999.  The latency related gene of bovine herpesvirus 1 inhibits programmed cell death induced by C6-ceramide or fumonisin B1.  J Virol, 73:9734-9740.
98. Winkler, M.T.C., A. Doster, and C. Jones. 1999. Bovine herpesvirus-1 can infect CD4+ T lymphocytes and induce programmed cell death during acute infection of cattle.  J Virol 73:8657-8568.
99. Ciacci-Zanella,  J.R.  and  C.  Jones.   1999.   Fumonisin  B1,  a  Mycotoxin  Contaminant  of Cereal  Grains,  Induces  Apoptosis  Via  The  Tumor  Necrosis  Factor  Pathway  And  Caspase Activation But Does Not Require p53. Food Chem Toxicol, 37:703-712.
100. Truesdell, G.M., C. Jones, T. Holt, G. Henderson, M.B. Dickman.  1999.  Hyphal defects and mammalian tumors induced by Ras from a phytopathogenic fungus. Molec Gen Genetics 262: 46-54.
101. Zhange, Y., M.B. Dickman, C. Jones. 1999. The mycotoxin Fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites. J Biol Chem  274:12367-12371.
102. Devireddy, L.R. and C. Jones. 1999. Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release. J Virol 73:3778-3788.
103. Ciacci-Zanella, J.R., A.H. Merrill Jr., E. Wang, C. Jones. 1998. Characterization of cell cycle arrest by fumonisin B1 in CV-1 cells. Food Chem Toxicol  36:791-804.
104. Jiang, Y., A. Hossain, M. T. Winkler, T. Holt, and C. Jones. 1998. Interaction between cyclin dependent kinases and the bovine herpes virus 1 latency related protein. J Virol 72:8133- 8142.
105. Devireddy, L.R. and C. Jones. 1998. Alternative splicing of the latency related transcript of bovine herpes virus type 1 yields RNAs containing unique open reading frames. J Virol 72:7294- 7301.
106. Delhon, D., L. Schang, and C. Jones. 1997. Characterization of a novel transcriptional promoter in the latency related gene of bovine herpes virus 1 which is active during a latent infection.  Virus Res 51:93-101.
107. Hossain, A., T. Holt, J. Ciacci-Zanella, and C. Jones. 1997. Analysis of cyclins and cyclin dependent kinases after an infection with herpes simplex virus.  J Gen Virol 78:3341-3348.
108. Schang, L.M. and C. Jones. 1997. Analysis of bovine herpes virus 1 transcripts during a primary infection of trigeminal ganglia of cattle.  J Virol 71:6786-6795.
109. Schang, L., A. Hossain, C. Jones. 1996. The latency related gene of bovine herpes virus type 1 encodes a factor which inhibits cell cycle progression.  J Virol 70:3807-3814.
110. Wang, H., C. Jones ,  J. Zanella,  T. Holt,  D. Gilchrist,  M. Dickman.   1996.   Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells.  Proc Natl Acad Sci 93:3461-3465.
111. Hossain, A., L. Schang, and C. Jones. 1995.  Identification of gene products encoded by the latency related gene of bovine herpes virus type 1. J Virol 69:5345-5352.
112. Huang, C., M. Dickman, G. Henderson, and C. Jones. 1995.  The fungal toxin, fumonisin B1, represses protein kinase C in mammalian cells. Cancer Res 55:1655-1659.
113. Banbura, M., C.E. Ackland, S.-H. Lee, D. Hamernik, and C.Jones. 1994. Analysis of transcriptional activation of a cAMP response element by 2,6,10,14 tetramethylpentadecance (Pristane) in JB6 mouse epidermal cells.  Molec Carcinogen 11:204-214.
114. Hanson, N. G. Henderson, and C. Jones. 1994. The herpes simplex virus 2 gene which encodes the large subunit of ribonucleotide reductase has unusual regulatory properties. Virus Res 34:265-280.
115. Wang, J., C. Jones, M. Norcross, E. Bohnlein, and A. Razzaque. 1994. Identification and characterization of a human herpesvirus 6  gene  segment capable  of transactivating  the  HIV LTR in a Sp1 binding site dependent manner.  J Virol 68:1706-1713.
116. Dhanwada, K.,   L. Garrett,   P. Smith,   K. Thompson, and C. Jones.   1993.   Analysis  of human keratinocytes transformed by HSV-2 and human papilloma virus 16 or 18. J Gen Virol 74:955-963.
117. Garrett, L., C. Ackland-Berglund, C. Jones, and M. Cuchens. 1993. Differential effects of TPA and pristane on gene expression and transformation in mouse epidermal cells. Exp Cell Res  205:416-421.
118. Jones, C., F. Zhu, and K. Dhanwada. 1993. An intergenic  element  of  HSV-2  gene encoding the large subunit of ribonucleotide reductase can function as a distal  activating element in human keratinocytes.  DNA Cell Biol 12:127-137.
119. Bratanich, A.C., N. Hanson, and C. Jones. 1992. The latency related gene of bovine herpesvirus 1 inhibits the activity of immediate early transcription unit 1.  Virology 191:988-991.
120. Bratanich, A.C. and Jones, C. 1992. Localization of cis-acting sequences in the latency- related promoter of bovine herpesvirus 1 which are regulated by neuronal cell type factors and immediate-early genes.  J Virol  66:6099-6106.
121. Dhanwada, K.R., V. Veerisetty, F. Zhu,  A. Razzaque,  K.D. Thompson,  and C. Jones. 1992. Characterization of human fibroblasts transformed by HPV-16 and HSV-2. J Gen Virol 73:791-799.
122. Soong, L., C. Ackland-Berglund, C. Jones. 1992. The tumor promoter pristane activates transcription by a cAMP dependent mechanism.  Molec Cell Biochem  110:75-81.
123. Garrett, L., C. Jones, and M. Cuchens. 1992. Pristane induced gene activation.  Chem- Biol Interactions  81:119-130.
124. Razzaque, A., F. Zhu, and C. Jones. 1991. Functional analysis of human cytomegalovirus (MTRII).  Virology  181:399-402.
125. Jones, C., G. Delhon, A. Bratanich, and D. Rock. 1990. Analysis of the transcriptional promoter which regulates the latency related transcript of bovine herpesvirus 1. J Virol 64:1164-1170.
126. Jones, C. 1989. The minimal transforming fragment of HSV-2 mtrIII can function as a complex promoter element.  Virology  169:346-353.
127. Razzaque, A.,  N. Jahan,  R. Jariwalla,  C. Jones, and L.J. Rosenthal.  1988.   Localization and sequence analysis of the transforming domain mtrII of human cytomegalovirus DNA. Proc Natl Acad Sci USA  85:5709-5713.
128. Jones, C. and R.T. Su. 1987. The association of viral and plasmid DNA with the nuclear matrix during a productive infection.  Biochem Biophys Acta  910:52-62.
129. Jones, C., J. Ortiz, and R.J. Jariwalla. 1986. Localization and  comparative  nucleotide sequence analysis of the transforming domain in herpes simplex virus DNA containing repetitive genetic elements.  Proc Natl Acad Sci USA  83:7855-7859.
130. Jariwalla, R.J., B. Tanczos, C. Jones, J.  Ortiz,  and  S.  Salimi-Lopez.  1986.  DNA amplification and neoplastic transformation mediated by a herpes simplex virus fragment containing cell-related sequences.  Proc Natl Acad Sci USA  83:1738-1742.
131. Jones, C. and Su, R.T. 1985. Association of simian virus 40 phosphorylated T-antigen with sub-nuclear fractions of infected and transformed cells.  Exp Cell Res  160:158-170.
132. Jones, C. and Su, R.T. 1982. DNA polymerase alpha from  the  nuclear  matrix  of  cells infected with SV40.  Nucleic Acids Res  10:5517-5531.

Book Chapters & Review Articles

1. Jones, C.  2015.  Reactivation from latency by α-herpesvirinae submfamily members: a stressful stimulation.  IN Press, Current Trends in Virology.
2. Jones, C.  2013.  Bovine herpesvirus 1 (BHV-1) and herpes simplex virus type 1 (HSV-1) promote survival of latently infected sensory neurons, in part by inhibiting apoptosis. J of Cell Death, 6:1-16.
3. Jones, C., L.F. da Silva, and D. Sinani. 2011.  Regulation of the latency-reactivation cycle by products encoded by the bovine herpesvirus 1  (BHV-1)  latency-related  gene.  J Neurovirology, 17: 535-545.
4. Chowdhury, S. and C. Jones. 2010. Bovine herpesvirus type 1 (BHV-1) is an important cofactor in the bovine respiratory disease complex. Veterinary Clinics of North America, Food Animal Practice, Bovine Respiratory Disease, eds V.L. Cooper and B. Broderson, 303-321.
5. G.-C. Perng and C. Jones. 2010. Towards an understanding of the Herpes Simplex Virus Type 1 latency-reactivation cycle. Interdisciplinary Perspectives on Infectious Diseases 2010:1- 18.
6. Jones, C. 2009.  Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0).  Viruses 1:255-275.
7. Jones, C. and E.M. Scholar. 2008. Viral Induced Encephalitis, Neuroimmune Pharmacology, T. Iketsu, H.E. Gendelman edts, p327-341 Springer.
8. Jones, C. and S. Chowdhury. 2008. A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex, and development of improved vaccines.  Adv in Animal Health, 8:187-205.
9. Jones, C.,  V. Geiser,  G. Henderson,  Y. Jiang,  F. Meyer,  S.  Perez, Y.  Zhang. 2006. Functional analysis of bovine herpesvirus 1 (BHV-1) genes expressed during latency. Vet Micro 113:199-210.
10. Jones, C. Analysis of HSV-1 and BHV-1 1 latency. 2003. Clin Micro Revs  16:79-95
11. Jones, C. 1998. Alphaherpesvirus latency: its role in disease and survival of the virus in nature.  Adv Virus Res  51:47-99.
12. Winter, C.K., D.G. Gilchrist, M.B. Dickman, C. Jones. 1996.  Chemistry and biological activity of AAL toxins.  In Fumonisins in Food, edited by L. Jackson et al. p 307-316.
13. Jones, C. Cervical Cancer: Is herpes simplex virus type 2 a cofactor? 1995. J Clin Micro Revs 8:549-556.