Education

Biography

Dr. Yanjun Shi joined the Hume-Lee Transplant Center on 2014. During this time, Dr. Shi worked as Clinical Instructor and Transplant Surgery and Hepatobiliary Surgery Fellow.

Dr. Shi’s clinical interest is liver transplant, kidney transplant, pancreas transplant and vascular access Surgery. His research interest includes liver transplant, ischemia reperfusion injury, primary non function and intravital image. He is an editorial reviewer for Hepatobiliary & Pancreatic Diseases International, journal of biomedical research, Journal of Chinese medicine, Redox Report. His own work has appeared in Liver Transplant, Journal of Hepatology and Transplantation etc.

In 2002, he received his M.D. from the Southeast University in Nanjing China.  Then he went on to do residencies in surgery at Nanjing Medical University and Shanghai Jiaotong University. He joined the Medical University of South Carolina in 2007 as transplant research fellow and micro-surgeon, became Clinical Instructor of surgery at MUSC in 2013. Then he joined Hume-Lee Center of Virginia Commonwealth University as Clinical Instructor. He continues his Transplant Surgery and Hepatobiliary Surgery Fellowship at VCU.

Research Interest

Liver transplant, Kidney transplant, Primary non-function, Ischemia reperfusion injury, Cell death and Intravital microscopic image.

Professional Activities:

Academic Appointment

Clinical experience outside USA

I did 5years surgical resident training in China. The training provided me with broad based clinical experience in an atmosphere of high academic standards and personalized training surgery. I am good at diagnosis, treatment, and management of patients with urological disorders and kidney transplantation. I have also been trained to performing the following surgical procedures: cadaver kidney transplantation, living donor kidney transplantation, including
organ procedure and implantation and perioperative management of kidney transplantation including ICU training. I am also good at urethral catheterization, placement of a suprapubic tube, cystoscopy, circumcision, hydrocelectomy, transurethral resection of simple bladder tumor, ureteral endoscopy and lithotripsy, flank procedures include  nephrectomy and retroperitoneal dissection, pelvic procedures including cystectomy and simple and radical prostatectomy, transurethral procedures, urethral stricture repairs, and radical orchiectomy.

US Clinical experience

1. Surgical Clerkship and Observation experience I did one month Surgical Clerkship at Transplant center and Acute care Surgery of Piedmont Hospital in Atlanta. I was involved in operations including piggyback Liver transplantation, combined kidney liver transplantation, cadaveric kidney transplantation, living donor kidney transplantation, hand assistant laparoscopy nephrectomy, robot laparoscopy nephrectomy. I also rotated at Acute Care Surgery of Piedmont hospital. I was involved in diagnosis and management of general surgery disease. I was involved in operations including laparoscopy cholecystectomy, Laparoscopy appendectomy, small bowel resection, hernia repair, colon tumor resection and colostomy and EEA colorectal anastomosis. After that, I did one year observation at MUSC Transplant center. I followed up liver and kidney transplant clinic, Morning Round, Morning report, Attending Round, liver selection meeting, kidney selection meeting, grand Round and M& M conference.
2. Hand on and Working Clinical Experience:
I officially joined the Transplant division of MUSC in 2013. I worked as a Donor surgeon. I obtained South Carolina Academic Medical License. My job responsibility was mainly focus on donor procurement and vascular access surgery. I have done 3 months rotation at STICU service of MUSC. Iam familiar with ICU management for critical care patients. I have done 40 donor recovery surgery (Livers, kidneys) as first assistant (including 7 cases of pancreas procurement). I have helped Liver Transplant backbench surgery about 40 cases as first assistant. I also have assisted liver transplant operation about 40 cases as second assistant. I have done about 150 cases of vascular access surgery as first assistant (including creation of new AV fistula, AV fistula revision, laparoscopic PD catheter placement and removal, perm Catheter placement and Temp Catheter Placement). I have also involved in kidney transplantation about 25 cases (including 2 cases of enblock pediatric kidney transplant), transplant nephrectomy(3 cases), combined kidney and pancreas transplant about 5 cases and other general surgery cases like Lap Cholecystectomy ,liver resection and incision hernia etc. I am currently working at HumeLee Transplant center at MCV. My Clinical interest is Liver and kidney transplant, vascular Access Surgery, Lap or open Nephrectomy and Hepatobiliary Surgery.

  Resear ch Experience

I worked on molecular and biochemical mechanism of mitochondrial dysfunction and oxidative stree involed in liver ischemia and liver transplantation. I have a huge amount of microsurgery experience. I can establish the liver transplantation (over 1000 cases), renal transplantation (over 200 cases) and heart transplantation (over 600 cases) in rat and mouse. I am currently working at HumeLee Transplant Center at MCV. My research interest is DCD liver transplant, ischemia reperfusion injury and transplant immunology.

Publications

1. Songqing He, Hasibur Rehman, Yanjun Shi, Yasodha Krishnasamy, John J. Lemasters, Rick G. Schnellmann, and Zhi Zhong. Suramin Decreases Injury and Improves Regeneration of Ethanol Induced Steatotic Partial Liver Grafts. Jour nal Of Pharmacology And Experiment Therapeutics.November 16, 2012 jpet.
2. Qinlong Liu, Hasibur Rehman, Yanjun Shi, Yasodha Krishnasamy, John J. Lemasters, Charles D. Smith, Zhi Zhong. Inhibition of Sphingosine Kinase2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transpl
3. antation in Rats. PLoS ONE.2012. 7(7): e41834. Yanjun Shi, Hasibur Rehman,Venkat K.Ramsheh, Justin Schuartz , Qinlong Liu, Yasodha Krishnasamy, Xun Zhang, John J. Lemaster, Charles D.Smith, and Zhi Zhong. Spingosine Kinase Inhibition improves mitochondrial fu nction and survival after Hepatic Ischemia Reperfusion in Mice. Journal of Hepatology. 2012, Vol. 56, Issue 1, 137145
4. Hasibur Rehman, Junjiang Sun,Yanjun Shi,Venkat K.Ramshesh, Qinlong Liu ,Robert T. Currin, John J.Lemasters and Zhi Zhong.NIM 811 Prevents Mitochondrial Dysfunction, Attenuates Liver Injury and Stimulates Liver Regeneration after Massive Hepatectomy. Transplantation.2011, Vol. 91(4), 406412
5. Yanjun Shi, Hasibur Rehman, Gary Wright, Zhi Zhong . Inhibition of Inducible Nitric Oxide Synthase Prevents Graft Injury After Transplantation of Livers from Rats After Cardiac Death. Liver Transplantation.2010, Vol.16. Issue 11, 12671277
6. Yanjun Shi, Ruipeng Jia, Jiageng Zhu. Establishment of rat model of com bined kidney adrenal gland allotransplantation. Journal of Biomedical Research . 2006, Vol. 20. No 3 .166168.
7. Yanjun Shi, Ruipeng Jia, Guangchen Zhou. The research of combined transplantation of kidney and adrenal gland. ACTA UNIVERSITATIS MEDICINALIS NANJ ING (Natur al Science). 2006, Vol. 26 No 5.367370.
8. Yanjun Shi, Ruipeng Jia. Glucocortocoid free immunosuppressive regimen in the renal transplantation. International Journal of Urology and Nephrology, 2006, Vol. 26. No. 1.7679.
9. Ruipeng Jia, Yanjun Shi, Jiageng Zhu. Immunoprotective effect of the simultaneous kidney and adrenal gland transplantation on transplanted kidney. J Tr ansplant , 2006, Vol.4. No. 3 101104.

Conference Paper

1. Yanjun Shi, Nicholas Jordan Reaves,Tucker J. Williamson, Jiangting Hu, Stephen Tomlinson and Carl Atkinson. The role of C3a and C3aR in ischemia reperfusion injury and acute rejection. American Transplant Congress Held Jun 26 2012 at John B Hynes Convention center, Boston, MA
2. Hasibur Rehman, Qinlong Liu, Yasodha Krishnasamy, Khujista Haque, Yanjun Shi, Shalini Saggu, John J. Lemasters, Charles Smith, and ZhiZhong. Role of Sphingosine Kinase2 in Acetaminophen Induced Liver Injury Digestive Disease Week held May 19 May 22, 2012 at San Diego Convention Center, San Diego, CA
3. Songqing He, Hasibur Rehman, Yasodha Krishnasamy, Yanjun Shi, Gary Wright, and Zhi Zhong. Ethyl 3,4dihyroxybenzoateStimulates Regeneration of Fatty Livers after Partial Hepatectomy. International Congr ess of Transplantation Society, July 1520, 2012, Berlin, Germany.
4. Hasibur Rehman, Qinlong Liu, Yasodha Krishnasamy, Yanjun Shi, Venkat K. Remshash, John J. Lemasters, Rick G. Schnellmann, and ZhiZhong. Changes in mitochondrial homeostasis after ischemia/reperfusion and partial hepatectomy. NHLBI Mitochondrial Biology Symposium 2011, Advances in Mitochondrial Dynamics and MitochondrialCytosolic Communications May 1617, 2011
5. Yanjun Shi, Hasibur Rehman, Charles D. Smith and Zhi Zhong Sphingosine Kinase2 is involved in Cold Storage/Reperfusion Injury during Orthotopic Rat Liver Transplantation. Digestive Disease Week held May 8 May 10, 2011 at McCormic Place In Chicago, Illinois, USA. Gastroenterology, Volume 140, Issue 5, Supplement 1, May 2011, Pages S967S968
6. Hasibur Rehman, Yasodha Krishnasamy, Yanjun Shi, Xun Zhang, John J. Lemasters, Charles D. Smith and Zhi Zhong. Sphingosine Kinase2 Plays an Important Role in Ischemia/Reperfusion Induced Hepatocyte Death. (Poster of Distinction Award) Digestive Disease Week held May 8May 10, 2011 at McCormic Place In Chicago, Illinois, USA. Gastroenterology, Volume 140, Issue 5, Supplement 1, May 2011, Pages S977
7. Qinlong Liu, Hasibur Rehman, Venkat K. Ramshesh, Yanjun Shi, John J. Lemasters, and Zhi Zhong. Female Mice are More Susceptible to Ethanol Induced Mitochondrial Depolarization: Studies by Intravital Multiphoton Microscopy.Digestive Disease Week held May 8May10, 2011 at McCormic Place in Chicago, Illinois, USA. Gastr oenter ology, Volume 140, Issue 5, Supplement 1, May 2011, Pages S 915
8. Hasibur Rehman, Qinlong Liu, Yasodha Krishnasamy, Yanjun Shi, Rick G. Schnellmann, and Zhi Zhong. Daidzein improves mitochondrial biogenesis after ischemia/reperfusion and partial hepatectomy. (Poster of Distinction Award) Digestive Disease Week held May 8May 10, 2011 at McCormic Place In Chicago, Illinois, USA. Gastroenterology, Volume 140, Issue 5, Supplement 1, May 2011, Pages S950S951
9. Zhi Zhong, Qinlong Liu, Hasibur Rehman, Songqing He, Yanjun Shi, Yasodha Krishnasamy and Rick G. Schnellmann. Supplementation of amphiregulin improves fatty liver regeneration after partial hepatectomy (PHX): the role of cJun Nterminal kinase (JNK) and extracellular signalregulated kinases (ERK). EXPERIMENTAL BIOLOGY 2011, APRIL 913, 2011WASHINGTON, DC, USA FASEB J March 17, 2011; 25:732.12
10. Zhi Zhong, Hasibur Rehman, Yasodha Krishnasamy, Qinlong Liu, Yanjun Shi, and Rick G. Schnellmann. Alterations of mitochondrial homeostasis after ischemia/reperfusion (IR) and partial hepatectomy (PHX) in mice. EXPERIMENTAL BIOLOGY 2011, APRIL 913, 2011WASHINGTON, DC, USA FASEB J March 17, 2011 25:998.10
11. Yanjun Shi, Hasibur Rehman, Charles D. Smith, and Zhi Zhong. Inhibition of Sphingosine Kinase Prevents Failure of Liver Grafts from NonHeart Beating Donors after Transplantation. International Congress of Transplantation Society, August 1519, 2010,Vancouver Convention Center, Canada Transplantation, Volume 90, supplement 2 S, July 27, 2010, pages 409
12. Hasibur Rehman, Yanjun Shi, and Zhi Zhong. Ischemia/reperfusion inhibits mitochondrial biogenesis after partial hepatectomy in mice. International Congr ess of Transplantation Society, August 1519, 2010, Vancouver Convention Center, Canada Transplantation, Volume 90, supplement 2 S, July 27, 2010, pages 839
13. Yanjun Shi, Hasibur Rehman, John J.Lemasters,Charles D Smith, Zhi Zhong. Sphingosine Kinase Is involved in Oxidative and Nitrative Stress after Liver Ischemia/Reperfusion. (Poster of Distinction Awar d) Digestive Disease Week held May 1May5, 2010 at Er nest N. Mor ial Convention center in New Or leans, USA. Gastr oenter ology, Volume 138, Issue 5, Supplement 1, May 2010, Pages S828
14. Hasibur Rehman, Songqing He, Yanjun Shi, Zhi Zhong. Inhibition of Amphiregulin Formation Contributes to Suppression of Fatty Liver Regeneration after Partial Hepatectomy. Digestive Disease Week held May 1May 5, 2010 at Ernest N. Mor ial Convention center in New Or leans, USA Gastroenterology, Volume 138, Issue 5, Supplement 1, May 2010, Pages S775
15. Yanjun Shi, Hasibur Rehman, Venkat K.Ramsheh, John J.Lemaster, Charles D.Smith, and Zhi Zhong. Role of Spingosine Kinase In Mitohondrial Dysfunction and Inflammation after Hepatic Ischemia Reperfusion In Mice. 2009Annual meeting of AASLD, Boston, USA. Hepatology, Vol. 50, Issue S4, Pages 883A
16. Yanjun Shi, Hasibur Rehman, Zhi Zhong .Inhibition of Inducible Nitric Oxide Synthase Prevents Injury to Liver grafts from Nonheart beating Donor. (Poster of Distinction Awar d) Digestive Disease Week held May 30J une 4, 2009 at McCormic Place In Chicago, Illinois, USA. Gastr oenter ology, Vol.136, Issue 5, Supplement 1, May 2009, Pages A81516.
17. Ruipeng Jia, Yanjun Shi .The use of MRU in the Diagnosis of ureter obstruction after kidney transplantation. Annual meeting of Chinese Ur ology Association, 2005, China P.R
18. Yanjun Shi, Ruipeng Jia, Jiageng Zhu. Establishment of rat model of the simultaneous kidney and adrenal gland transplantation. Annual meeting of Chinese Ur ology Association, 2005, China P.R.