Publications

Full Length, Peer-Reviewed, Original Articles

  1. Rodriguez M, Sahgal V, Subramani M: Neurotransmitters in Spinal Cord Injury. Arch. Phys. Med. Rehabil. 1977;58(12):547-554.
  2. Rodriguez M, Dinapoli R: Spinal Cord Compression with Special Reference to Metastatic Epidural Tumors.  Mayo Clin. Proc. 1980;55:442-448.
  3. Rodriguez M, Gomez MR, Howard FM, Taylor F: Myasthenia Gravis in Children: Long Term Follow-Up.  Trans. Amer. Neurol. Assoc. 1981;106:210-212.
  4. Rodriguez M, Baele PL, Marsh HM, Okazaki H: Central Neurogenic Hyperventilation in an Awake Patient with Brainstem Astrocytoma.  Ann. Neurol. 1982;11(6): 625-628.
  5. Rodriguez M, O'Brien JS, Garrett RS, Powell HC: Canine GM1 Gangliosidosis: An Ultrastructural and Biochemical Study.  J. Neuropath. Exp. Neurol. 1982; 41:618-629.
  6. Oldstone MBA, Sinha YN, Blount P, Tishon A, Rodriguez M, von Wedel R, Lampert PW: Virus-Induced Alterations in Homeostasis: Alterations in Differentiated Functions of Infected Cells in vivo.  Science 1982;218:1125-1127.
  7. Rodriguez M, Powell HC, Lampert PW: Demyelination and Leukodystrophy.  The Clinical Neurosciences.  Rosenberg RN, Grossman RG, Schochet S, editors, Churchill Livingstone.  1983;3:419-445.
  8. Rodriguez M, Buchmeier MJ, Oldstone MBA, Lampert PW: Ultrastructural Localization of Viral Antigens in the CNS of Mice Persistently Infected with Lymphocytic Choriomeningitis Virus (LCMV).  Am. J. Path. 1983;110:95-100
  9. Rodriguez M, Gomez MR, Howard FM, Taylor WF: Myasthenia Gravis in Children: Long-Term Follow-Up.  Ann. Neurol.  1983;13:504-510.
  10. Knobler RL, Rodriguez M, Lampert PW, Oldstone MBA: Virologic Models of Chronic Relapsing Demyelinating Disease.  Acta Neuropathol 1983;9:31-37.
  11. Powell HC, Braheny SL, Myers RR, Rodriguez M, Lampert PW: Early Changes in Experimental Allergic Neuritis.  Lab. Invest. 1983;48:332-338.
  12. Rodriguez M, Leibowitz JL, Lampert PW: Persistent Infection of Oligodendrocytes in Theiler's Virus-Induced Encephalomyelitis.  Ann. Neurol. 1983;13:426-433.
  13. Leibowitz JL, Rodriguez M: Antigenic Variants are not selected During Persistent Infection with Theiler's Virus.  Infect. Immun. 1983;41:440-442.
  14. Rodriguez M, von Wedel RJ, Garrett RS, Lampert PW, Oldstone MBA: Pituitary Dwarfism in Mice Persistently Infected with Lymphocytic Choriomeningitis Virus. Lab. Invest. 1983;49:48-53.
  15. Lampert PW, Rodriguez M: Virus Induced Demyelination: IN Concepts in Viral Pathogenesis.  Notkins AL, Oldstone MBA, editors, Springer-Verlag, New York.  1984;37:260-268.
  16. Rodriguez M, Leibowitz JL, Powell HC, Lampert PW: Neonatal Infection with the Daniels Strain of Theiler's Murine Encephalomyelitis Virus.  Lab. Invest. 1984;49:672-679.
  17. Powell HC, Rodriguez M, Hughes RAC: Microangiopathy of Vasa Nervorum in Dysglobulinemic Neuropathy.  Ann. Neurol.1984;15:386-394.
  18. Oldstone MBA, Rodriguez M, Daughaday WH, Lampert PW: Viral Perturbation of Endocrine Function: Disordered Cell Function Leads to Disturbed Homeostasis and Disease.  Nature 1984;307:278-281.
  19. Oldstone MBA, Southern P, Rodriguez M, Lampert P.  Virus Persists in b Cells of Islets of Langerhans and is Associated with Chemical Manifestations of Diabetes.  Science 1984;224:1440-1443.
  20. Lang W, Rodriguez M, Lennon VA, Lampert PW: Demyelination and Remyelination in Murine Viral Encephalomyelitis.  Multiple Sclerosis: Experimental and Clinical Aspects.  Ann. N. Y. Acad. Sci. 1984;436:98-102.
  21. Vroman B, Luka J, Rodriguez M, Pearson G: Characterization of a Major Protein with a Molecular Weight of 160,000 Associated with the Viral Capsid of the Epstein-Barr Virus.  J. Virol. 1984;53:107-113.
  22. Rodriguez M, Garrett RS, Raitt M, Lampert PW, Oldstone MBA: Virus Persists in Beta cells of Islets of Langerhans and Infection is Associated with Chemical Manifestations of Diabetes.  II. Morphologic Observations.  Am. J. Pathol. 1985;121:497-504.
  23. Rodriguez M: Virus-Induced Demyelination in Mice: "Dying Back" of Oligodendrocytes.            Mayo Clin. Proc. 1985;60:433-438.
  24. Rodriguez M, David CS: Demyelination Induced by Theiler's Virus: Influence of the H-2 Haplotype.  J. Immunol. 1985;135(3): 2145-2148.
  25. Rodriguez M, Powell HC: Dysglobulinemic Neuropathy: Absence of Immunoglobulin Within Myelin Sheaths.  Ann. Neurol. 1986;19:204-206.
  26. Kooistra KL, Rodriguez M, Powis G, Yaksh TL, Harty GJ, Hilton JF, Laws ER: Development of Experimental Models for Meningeal Neoplasia using Intrathecal Injection of 9L Gliosarcoma and Walker 256 Carcinosarcoma in the Rat.  Cancer Res. 1986;46:317-323.
  27. Rodriguez M, Leibowitz J, David CS: Susceptibility to Theiler's Virus-Induced Demyelination: Mapping of the Gene within the H-2D Region.  J. Exp. Med. 1986;163:620-631.
  28. Rodriguez M, Lafuse W, Leibowitz J, David CS: Partial Suppression of Theiler's Virus-Induced Demyelination In Vivo by Administration of Monoclonal Antibodies to Immune- Response Gene Products (Ia Antigens).  Neurology 1986;36:964-970.
  29. Peters MS, Rodriguez M, Gleich GJ: Localization of Human Eosinophil Granule Major Basic Protein, Eosinophil Cationic Protein, and Eosinophil-Derived Neurotoxin by Immunoelectron Microscopy.  Lab. Invest. 1986;54:656-662.
  30. Rodriguez M, Quddus J: Effect of Cyclosporin A, Silica Quartz Dust, and Protease Inhibitors on Virus-Induced Demyelination.  J. Neuroimmunol. 1986;13:159-174.
  31. Rodriguez M, Pease LR, David CS: Immune-Mediated Injury of Virus-Infected Oligodendrocytes.  A Model of Multiple Sclerosis.  Immunol. Today 1986;7:359-363.
  32. Rodriguez M, Lennon V, Benveniste EN, Merrill JE: Remyelination by Oligodendrocytes Stimulated by Antiserum to Spinal Cord.  J. Neuropath. Exp. Neurol. 1987;46:84-95.
  33. Stewart JM, Houser OW, Baker HL, O'Brien PC, Rodriguez M: Magnetic Resonance Imaging and Clinical Relationships in Multiple Sclerosis.  Mayo Clin. Proc. 1987;62:174-184.
  34. Woloschak GE, Rodriguez M, Krco CJ: Characterization of Immunologic and Neuropathologic Abnormalities in Wasted Mice.  J. Immunol. 1987;138:2493-2499.
  35. Rodriguez M, Pierce ML, Howie, EA: Immune Response Gene Products (Ia Antigens) on Glial and Endothelial Cells in Virus-Induced Demyelination.  J. Immunol. 1987;138:3438-3442.        
  36. Rodriguez M, Oleszak E, Leibowitz J: Theiler’s Murine Encephalomyelitis: A Model of Demyelination and Persistence of Virus.  Critical Reviews in Immunology, CRC Press, 1987;7(4) 325-365.
  37. Woloschak GE, Rodriguez M, Krco CJ: Immunoglobulin Gene Expression in Wasted Mice.  Adv. Exp. Med. Biol. 1987;216A:23-30.
  38. Leibowitz JL, DeVries JR, Rodriguez M: Increased Hepatotropism of Mutants of MHV, Strain JHM, Selected with Monoclonal Antibodies.  Adv. Exp. Med. Biol. MMC Lai, SA Stohlman, LS Weiner, eds., 1987;218:321-331.
  39. Rodriguez M: Mechanisms of Virus-Induced Demyelination and Remyelination.  Ann N Y Acad Sci 1988;540:240-251.
  40. Rodriguez M, Lucchinetti CF, Clark RJ, Yaksh TL, Markowitz H, Lennon VA: Immunoglobulins and Complement in Demyelination Induced in Mice by Theiler's Virus.  J. Immunol. 1988;140:800-806.
  41. Griffith IJ, Nabavi N, Ghogawala Z, Chase CG, Rodriguez M, McKean DJ, Glimcher LH: Structural Mutation Affecting Intracellular Transport and Cell Surface Expression of Murine Class II Molecules.  J. Exp. Med. 1988;167:541-555.
  42. Lindsley MD, Thiemann RL, Rodriguez M: Enumeration and Distribution of T-Cell Subsets, Macrophages, and IgG Positive Cells in the CNS of SJL/J Mice Infected with Theiler's Virus.  Ann. N. Y. Acad. Sci. 1988;540:657-660.
  43. Rodriguez M, Siegel LM, Hovanec-Burns D, Bologa L, Graves MC: Theiler’s Virus-Associated Antigens on the Surfaces of Cultured Glial Cells. Virology  1988;166:463-474.
  44. Hormes JT, Benarroch E, Rodriguez M, Klass DW: Periodic Sharp Waves in Baclofen-Induced Encephalopathy.  Arch. Neurol. 1988;45:814-815.
  45. Rodriguez M, Sriram S: Successful Therapy of Theiler’s Virus-Induced Demyelination (DA Strain) with Monoclonal Anti-Lyt-2 Antibody.  J. Immunol.  1988;140:2950-2955.
  46. Rodriguez M, Truh LI, O'Neill BP, Lennon VA: Autoimmune Paraneoplastic Cerebellar Degeneration: Ultrastructural Localization of Antibody-binding Sites in Purkinje Cells.  Neurology 1988;38:1380-1386.
  47. Woloschak GE, Krco CJ, Rodriguez M: Influences of the Microenvironment on B-cell Responses on Wasted Mice: Comparison of Peyer's Patches and Mesenteric Lymph Nodes.  Reg. Immunol. 1988;1:163-171.  
  48. Oleszak EL, Leibowitz JL, Rodriguez M: Isolation and Characterization of Two Plaque Size Varients of Theiler’s Murine Encephalomyelitis Virus (DA Strain).  J. Gen. Virol. 1989;69:2413-2418.          
  49. Rodriguez M: Multiple Sclerosis: Basic Concepts and Hypothesis.  Mayo Clin. Proc. 1989;64:570-576.
  50. Carter JL, Rodriguez, M: Immunosuppressive Treatment of Multiple Sclerosis.  Mayo Clin. Proc. 1989;64:664-669.
  51. Wynn D, Rodriguez M, O'Fallon WM, Kurland LT: Update on the Epidemiology of Multiple Sclerosis.  Mayo Clin. Proc. 1989;64:808-817.
  52. Kooistra K, Rodriguez, M, Powis, G: Toxicity of Intrathecally Administered Cytotoxic Drugs and their Antitumor Activity Against an Intrathecal Walker 256 Carcinosarcoma Model for Meningeal Carcinomatosis in the Rat.  Cancer Res. 1989;49:977-982.
  53. Sriram S, Topham, DJ, Huang SK, Rodriguez M: Treatment of Encephalomyocarditis Virus-Induced Central Nervous System Demyelination with Monoclonal Anti-T Cell Antibodies.  J. Virol. 1989;63:4242-4248.
  54. Woloschak GE, Krco CJ, Rodriguez M: Anti-m Treatment Suppresses Immunoglobulin Light-Chain Gene Expression and Peyer's Patch Development.  Molec. Immunol. 1989;26:351-358.
  55. Pierce M, Rodriguez M: Erichrome Stain for Myelin on Osmicated Tissue Embedded in Glycol Methacrylate Plastic.  J. Histotech. 1989;12:35-36.
  56. Gaumann DM, Yaksh TL, Post C, Wilcox GL, Rodriguez M: Intrathecal Somatostatin in Cat and Mouse: Studies on Pain, Motor Behavior and Histopathology.  Anesth. Analg. 1989;68:623-632.
  57. Paya CV, Patick A, Leibson PJ, Rodriguez M: Role of Natural Killer Cells as Immune Effectors in Encephalitis and Demyelination Induced by Theiler's Virus.  J. Immunol. 1989;143:95-102.
  58. Lindsley MD, Rodriguez M: Characterization of the Inflammatory Response in the Central Nervous System of Mice Susceptible or Resistant to Demyelination by Theiler's Virus.  J. Immunol. 1989;142:2677-2682.
  59. Lutsep HL, Rodriguez M: Ultrastructural, Morphometric and Immunocytochemical Study of Anterior Horn Cells in Mice with "Wasted" Mutation.  J. Neuropath. Exp. Neurol. 1989;48:519-533.
  60. Rodriguez M, Lennon VA: Immunoglobulins Promote Remyelination in the Central Nervous System.  Ann. Neurol. 1990;27:12-17.
  61. Rodriguez M, Wynn DR, Kimlinger TK, Katzmann JA: Terminal Component of Complement (C9) in the Cerebrospinal Fluid of Patients with Multiple Sclerosis and Neurologic Controls.  Neurology.  1990;40:855-857.
  62. Carter JL, Rodriguez M: Newer Drug Therapies for Multiple Sclerosis.  Drug Therapy. 1990; 20(3): 31-43.
  63. Wynn DR, Rodriguez M, O'Fallon WM, Kurland LT: A Reappraisal of the Epidemiology of Multiple Sclerosis in Olmsted County, Minnesota.  Neurology 1990;40:780-786.
  64. Rodriguez M, Kenny JJ, Thiemann RL, Woloschak GE: Theiler’s Virus-induced Demyelination in Mice Immunosuppressed with Anti-IgM and in Mice Expressing xid Gene.  Microbiol. Path. 1990;8:23-35.
  65. Rodriguez M, Patick AK, Pease LR: Abrogation of Resistance to Theiler's Virus-Induced Demyelination in C57BL Mice by Total Body Irradiation.  J. Neuroimmunol.1990; 26:189-199.
  66. Patick AK, Lindsley MD, Rodriguez M: Differential Pathogenesis between Mouse Strains Resistant and Susceptible to Theiler's Virus-Induced Demyelination.  Seminars in Virology 1990;1:281-288.
  67. Paya CV, Leibson PJ, Patick AK, Rodriguez M: Inhibition of Theiler's Virus-Induced Demyelination in vivo by Tumor Necrosis Factor Alpha.  Int. Immunol. 1990;2:909-913.
  68. Patick AK, Oleszak EL, Leibowitz JL, Rodriguez M: Persistent Infection of a Glioma Cell Line Generates a Theiler's Virus Variant which Fails to Induce Demyelinating Disease in SJL/J Mice. J. Gen. Virol. 1990;71:2123-2132.
  69. Patick AK, Pease LR, David CS, Rodriguez M: Major Histocompatibility Complex-Conferred Resistance to Theiler's Virus-Induced Demyelinating Disease is Inherited as a Dominant Trait in B10 Congenic Mice.  J. Virol. 1990;64:5570-5576.
  70. Fu J, Rodriguez M, Roos RP: Strains from both Theiler's Virus Subgroups Encode a Determinant for Demyelination.  J. Virol. 1990;64:6345-6348.
  71. Gaumann DM, Grabow TS, Yaksh TL, Casey SJ, Rodriguez M: Intrathecal Somatostatin, Somatostatin Analogs, Substance P Analog and Dynorphin a Cause Comparable Neurotoxicity in Rats.  Neuroscience 1990;39:761-774.
  72. Rodriguez M, Pierce ML, Thiemann RL: Immunoglobulins Stimulate Central Nervous System Remyelination: Electron Microscopic and Morphometric Analysis of Proliferating Cells.  Lab. Invest. 1991;64:358-370.
  73. Rodriguez M, Nickerson C, Patick AK, David CS: Expression of Human HLA-B27 Transgene Alters Susceptibility to Murine Theiler's Virus-Induced Demyelination.  J. Immunol. 1991;146:2596-2602.
  74. Carter J, Rodriguez M: The Immunopathology of Multiple Sclerosis.  Curr. Opin. Neurol. Neurosurg. 1991;4:186-190.  
  75. Rodriguez M, O’Fallon WM, Kurland LT: Epidemiology of MS (Reply from the authors).  Neurology(letter) 1991;41:158.
  76. Caselli RJ, Scheithauer BW, Bowles CA, Trenerry MR, Meyer FB, Smigielski JS, Rodriguez M: The Treatable Dementia of Sjögren's Syndrome: Clinical, Neuropsychologic, Radiologic and Histopathologic Correlation.  Ann. Neurol., 1991;30:98-101.
  77. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M: Multiple Sclerosis: Histopathologic and MR and/or CT Correlation in 37 Cases at Biopsy and Three Cases at Autopsy.  Radiology 180:467-474, 1991.
  78. Prayoonwiwat N, Pease LR, and Rodriguez M: Human T-Cell Lymphotropic Virus Type I Sequences Detected by Nested Polymerase Chain Reactions are not Associated with Multiple Sclerosis.  Mayo Clin. Proc. 1991; 66:665-680.
  79. Patick AK, Thiemann RL, O'Brien PC, Rodriguez M: Persistence of Theiler's Virus Infection Following Promotion of Central Nervous System Remyelination.  J. Neuropath. Exp. Neurol. 1991;50:523-537.
  80. Altermatt HJ, Rodriguez M, Scheithauer B, Lennon VA: Paraneoplastic Anti-Purkinje and Type I Anti-Neuronal Nuclear Autoantibodies Bind Selectively to Central, Peripheral and Autonomic Nervous System Cells.  Lab. Invest. 1991;65:412-420.
  81. Lindsley MD, Thiemann R, Rodriguez M: Cytotoxic T Cells Isolated from the Central Nervous Systems of Mice Infected with Theiler's Virus.  J. Virol. 1991;65:6612-6620.
  82. Rodriguez M, Lindsley MD, Pierce ML: Role of T-cells in Resistance to Theiler's Virus Infection.  Microb. Pathog. 1991;11:269-281.
  83. Rodriguez M, Roos RP: Pathogenesis of Early and Late Disease in Mice Infected with Theiler's Virus using Intratypic Recombinant GDVII/DA Viruses.  J. Virol. 1992;66:217-225.
  84. Rodriguez M, Patick AK, Pease LR, David CS: Role of T Cell Receptor Vb Genes in Theiler's Virus-Induced Demyelination of Mice.  J. Immunol. 1992;148:921-927.
  85. Rodriguez M, Lindsley M: Immunosuppression Promotes CNS Remyelination in Chronic Virus Induced Demyelinating Disease.  Neurolog y. 1992; 42:348-357.
  86. Anderson DW, Ellenberg JH, Leventhal CM, Reingold SC, Rodriguez M, Silberberg DH: Revised Estimate of the Prevalence of Multiple Sclerosis in the United States.  Ann. Neurol. 1992; 31:333-336.
  87. Hook CC, Kimmel DW, Kvols LK, Scheithauer BW, Forsyth PA, Rubin J, Moertel GG, Rodriguez M: Multifocal Inflammatory Leukoencephalopathy with 5-Fluorouracil and Levamisole.  Ann. Neurol. 1992;31:262-267.
  88. Lindsley MD, Patick AK, Prayoonwiwat N, Rodriguez M: Coexpression of Class I Major Histocompatibility Antigen and Viral RNA in Central Nervous System of Mice Infected with Theiler's Virus: A Model for Multiple Sclerosis.  Mayo Clin. Proc. 1992;67:829-838.
  89. Rodriguez M: Central Nervous System Demyelination and Remyelination in Multiple Sclerosis and Viral Models of Disease.  J. Neuroimmunol. 1992;40:255-264.
  90. van Engelen BGM, Hommes OR, Pinckers A, Cruysberg JRM, Barkhof F, Rodriguez M:  Improved Vision after Intravenous Immunoglobulin in Stable Demyelinating Optic Neuritis.  Ann. Neurol. 1992;32:834-835.
  91. Prayoonwiwat N, Rodriguez M: The Potential for Oligodendrocyte Proliferation during Demyelinating Disease.  J. Neuropath. Exp. Neurol. 1993;52:55-63.
  92. Rodriguez M, Pedrinaci S, David CS: Human Class I Major Histocompatibility Complex Transgene Prevents Virus-Induced Demyelination in Susceptible Mutant B10.D2dm1 Mice.  Ann. Neurol.  1993;33: 208-212.
  93. Rodriguez M, Karnes WE, Bartleson JD, Pineda AA: Plasmapheresis in Acute Episodes of Fulminant CNS Inflammatory Demyelination.  Neurology 43:1100-1104, 1993.
  94. van Engelen BGM, Hommes OR, Pinckers A, Cruysberg JRM, Barkhof F, Rodriguez M:  Caveat Regarding Immunoglobulin Therapy in Multiple Sclerosis (Reply).  Ann. Neurol(letter). 1993;33:660-661.
  95. Rodriguez M, Scheithauer BW, Forbes G, Kelly PJ: Oligodendrocyte Injury is an Early Event in Lesions of Multiple Sclerosis.  Mayo Clin. Proc. 1993;68:627-636.
  96. Rodriguez M, Dunkel AJ, Thiemann RL, Leibowitz J, Zijlstra M, Jaenisch R: Abrogation of Resistance to Theiler's Virus-induced Demyelination in H-2b Mice Deficient in b2- Microglobulin. J. Immunol. 1993;151:266-276.
  97. Siva A, Radhakrishnan K, Kurland LT, O'Brien PC, Swanson JW, Rodriguez M: Trauma and Multiple Sclerosis: A Population-based Cohort Study from Olmsted County, Minnesota.  Neurology. 1993;43:1878-1882.
  98. Rodriguez M, Prayoonwiwat N, Zhou Z, David C: Expression of T Cell Receptor Vb Transcripts in Central Nervous System of Mice Susceptible and Resistant to Theiler's Virus-induced Demyelination.  J. Neuroimmunol. 1993; 47:95-100.
  99. Altintas A, Cai Z, Pease LR, Rodriguez M: Differential Expression of H-2K and H-2D in the Central Nervous System of Mice Infected with Theiler's Virus.  J. Immunol. 1993;151:2803-2812.
  100. Rodriguez M, Scheithauer B: Ultrastructure of Multiple Sclerosis.  Ultrastruct. Pathol. 1994;18:3-13.
  101. Rodriguez M, Siva A, Ward J, Stolp-Smith K, O'Brien P, Kurland LT: Impairment, Disability, and Handicap in Multiple Sclerosis: A Population-based Study in Olmsted County, Minnesota.  Neurology 1994;44:28-33.
  102. Iuliano BA, Schmelzer JD, Thiemann RL, Low PA, Rodriguez M: Motor and Somatosensory Evoked Potentials in Mice Infected with Theiler's Murine Encephalomyelitis Virus.  J. Neurol. Sci. 1994;123:186-194.
  103. van Engelen BGW, Miller DJ, Rodriguez M:  Polyclonal Ig: An immunopharmacon?  Immunol. Toda.y 1994;15:341-342.
  104. Rodriguez M, Prayoonwiwat N, Howe C, Sanborn K: Proteolipid Protein Gene Expression in Demyelination and Remyelination of the Central Nervous System: A Model for Multiple Sclerosis.  J. Neuropath. Exp. Neurol. 1994:53:136-143.
  105. Rodriguez M, Pavelko K, McKinney CW, Leibowitz J: Recombinant Human IL-6 Suppresses Demyelination in a Viral Model of Multiple Sclerosis.  J. Immunol. 1994;153:3811-3821.
  106. Miller DJ, Sanborn KS, Katzmann JA, Rodriguez M: Monoclonal Autoantibodies Promote Central Nervous System Repair in an Animal Model of Multiple Sclerosis.  J. Neurosci. 1994;14:6230-6238.
  107. van Engelen BGM, Miller DJ, Pavelko KD, Hommes OR, Rodriguez M:  Promotion of Remyelination by Polyclonal Immunoglobulin in Theiler's Virus-induced Demyelination and in Multiple Sclerosis.  J. Neurol. Neurosurg. Psych. 1994;57:65-68.
  108. Noseworthy JH, O'Brien PC, van Engelen BGM, Rodriguez M: Intravenous Immunoglobulin Therapy in Multiple Sclerosis.  Progress from Remyelination in the Theiler's Virus Model to a Randomized, Double blind, and Placebo-controlled Clinical Trial.  J. Neurol. Neurosurg. Psych. 1994;57:11-14.
  109. Rodriguez M, Miller DJ: Immune Promotion of Central Nervous System Remyelination.  Prog. Brain Res. 1994;103:343-355.
  110. Rodriguez M, Nabozny GH, Thiemann, RL, David CS: Influence of Deletion of T cell Receptor Vb Genes on the Theiler's Virus Model of Multiple Sclerosis.  Autoimmunit.y 1994;19:221-230.
  111. Rodriguez M, Siva A, Cross SA, O'Brien P, Kurland LT:  Optic Neuritis: A Population-based Study in Olmsted County, Minnesota.  Neurology 1995;45:244-250.
  112. Kimmel DW, Wijdicks EFM, Rodriguez M: Multifocal Inflammatory Leukoencephalopathy Associated with Levamisole Therapy.  Neurology 1995;45:374-376.
  113. Miller DJ, Rodriguez M: A Monoclonal Autoantibody that Promotes Central Nervous System Remyelination in a Model of Multiple Sclerosis is a Natural Antibody Encoded by Germline Immunoglobulin Genes.  J. Immunol. 1995;154:2460-2469.
  114. Rodriguez M, David CS: H-2Dd Transgene Suppresses Theiler's Virus-Induced Demyelination in Susceptible Strains of Mice.  J. NeuroVirol. 1995;1:111-117.
  115. Miller DJ, Rodriguez M: Spontaneous and Induced Remyelination in Multiple Sclerosis and the Theiler's Virus Model of Central Nervous System Demyelination.  In, Microscopic Aspects of Myelin and Demyelinating Diseases.  Microscopy Research and Technique 1995;32:230-245.
  116. Hunter S, Rodriguez M: Multiple Sclerosis: A Unique Immunopathological Syndrome of the Central Nervous System.  Springer Semin. Immunopathol. 1995;17:89-105.
  117. Miller DJ, Asakura K, Rodriguez M: Experimental Strategies to Promote Central Nervous System Remyelination in Multiple Sclerosis: Insights gained from the Theiler's Virus Model System.  J. Neurosci. Res. 1995;41:291-296.
  118. Rodriguez M, Pavelko K, Coffman RL: Gamma Interferon is Critical for Resistance to Theiler's Virus-Induced Demyelination.  J. Virol. 1995;69:7286-7290.
  119. Miller DJ, Rivera-Quiñones C, Njenga MK, Leibowitz JL, Rodriguez M: Spontaneous CNS Remyelination in b2 Microglobulin-Deficient Mice Following Virus-Induced Demyelination.  J. Neurosci. 1995;15:8345-8352.
  120. Rodriguez M: Microscopy of Central Nervous System Myelin Diseases.  Microsc. Res. Tech. 1995;32(3): 181-182.
  121. Lin X, Thiemann R, Pease LR, Rodriguez M: VP1 and VP2 Capsid Proteins of Theiler's Virus are Targets of H-2D-restricted Cytotoxic Lymphocytes in the Central Nervous System of B10 Mice.  Virology. 1995; 214:91-99.
  122. Asakura K, Miller DJ, Pogulis RJ, Pease LR, Rodriguez M: Oligodendrocyte-reactive 01, 04 and HNK1 Monoclonal Antibodies are Encoded by Germline Immunoglobulin Genes.  Molec. Brain Res. 1995;34:283-293.
  123. Miller DJ, Njenga MK, Murray PD, Leibowitz JL, Rodriguez M: A Monoclonal Natural Autoantibody that Promotes Remyelination Suppresses Central Nervous System Inflammation and Increases Virus Expression after Theiler's Virus-Induced Demyelination.  Int. Immunol. 1996;8:131-141.
  124. Njenga MK, Pavelko KD, Baisch J, Lin X, David CS, Leibowitz JL, Rodriguez M: Theiler’s Virus Persistence and Demyelination in Major Histocompatibility Complex Class II-Deficient Mice.  J. Virol. 1996;70:1729-1737.
  125. Asakura K, Miller DJ, Murray K, Bansal R, Pfeiffer SE, Rodriguez M:  Monoclonal Antibody SCH94.03, Which Promotes Central Nervous System Remyelination, Recognizes an Antigen on the Surface of Oligodendrocytes.  J. Neurosci. Res. 1996;43:273-281.
  126. Asakura K, Pogulis RJ, Pease LR, Rodriguez M: A Monoclonal Autoantibody which Promotes Central Nervous System Remyelination is Highly Polyreactive to Multiple known and Novel Antigens.  J. Neuroimmunol. 1996;65:11-19.
  127. Miller DJ, Rodriguez M: Spontaneous Central Nervous System Remyelination in Stain A Mice after Infection with the Daniel’s (DA) Strain of Theiler’s Virus.  Acta Neuropathol. 1996;91:559-565.
  128. Rodriguez M, Miller DJ, Lennon VA: Immunoglobulins Reactive with Myelin Basic Protein Promote CNS Remyelination.  Neurology 1996;46:538-545.
  129. Miller DJ, Asakura K, Rodriguez M: Central Nervous System Remyelination.  Clinical Application of Basic Neuroscience Principles.  Brain Pathol. 1996;6:331-344.
  130. Njenga MK, Rodriguez M: Animal Models of Demyelination.  Curr. Opin. Neurol. 1996;9(3): 159-164.
  131. Lucchinetti CF, Bruck W, Rodriguez M, Lassmann H: Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis.  Brain Pathol. 1996;6:259-274.
  132. Miller DJ, Njenga MK, Parisi JE, Rodriguez M: Multi-organ Reactivity of a Monoclonal Natural Autoantibody that Promotes Remyelination in a Mouse Model of Multiple Sclerosis.  J. Histochem. Cytochem. 1996;44:1005-1011.
  133. Cornblath DR, Braine H, Dyck PJ, Mendell JR, Rodriguez M, Ropper AH, Wolinsky JS: Therapeutics and Technology Assessment Subcommittee.  Assessment of Plasmapheresis.  Neurology 1996:47:840-843.
  134. Rodriguez M, Pavelko K, Njenga MK, Logan W, Wettstein P: The Balance Between Persistent Virus Infection and Immune Cells Determines Demyelination.  J. Immunol. 1996;157:5699-5709.
  135. Armon C, Swanson JW, McLean JM, Westbrook PR, Okazaki H, Kurtin PJ, Kalyan-Raman UP, Rodriguez M: Subacute Encephalomyelitis Presenting as Stiff-Person Syndrome: Clinical, Polygraphic and Pathologic Correlations.  Mov. Disord. 1996;11:701-709.
  136. Sriram S, Rodriguez M: Indictment of the Microglia as the Villain in Multiple Sclerosis.  Neurology 1997;48:464-470.
  137. Kumar R, Maraganore DM, Ahlskog JE, Rodriguez M: Treatment of Putative Immune-Mediated and Idiopathic Cervical Dystonia with Intravenous Methylprednisolone.  Neurology 1997;48:732-735.
  138. Lin X, Pease LR, Rodriguez M: Differential Generation of Class I H-2D- Versus H-2K-Restricted Cytotoxicity Against a Demyelinating Virus Following Central Nervous System Infection.  Eur. J. Immunol. 1997;27:963-970.
  139. Miller DJ, Bright JJ, Sriram S, Rodriguez M: Successful Treatment of Established Relapsing Experimental Autoimmune Encephalomyelitis in Mice with a Monoclonal Natural Autoantibody.  J. Neuroimmunol.1997;75:204-209.
  140. Rodriguez M, Rivera-Quiñones C, Murray PD, Njenga MK, Wettstein PJ, Mak T: The Role of CD4+ and CD8+ T Cells in Demyelinating Disease Following Theiler’s Virus Infection: A Model for Multiple Sclerosis.  J. NeuroVirology 3(Supp 1): 1997;S43-S45.
  141. Asakura K, Hunter SF, Rodriguez M: Effects of Transforming Growth Factor-b and Platelet-Derived Growth Factor on Oligodendrocyte Precursors: Insights Gained from a Neuronal Cell Line.  J. Neurochem. 1997;68:2281-2290.
  142. Rodriguez M: Multiple Sclerosis: Insights into Molecular Pathogenesis and Therapy.  Introduction for Symposium on Multiple Sclerosis, Mayo Clin Proc. 1997;72:663-664.
  143. Lucchinetti CF, Rodriguez M: The Controversy Surrounding the Pathogenesis of the Multiple Sclerosis Lesion.  Mayo Clin Proc. 1997;72:665-678.
  144. Taupin V, Renno T, Bourbonniere L, Peterson AC, Rodriguez M, Owens T.: Increased Severity of Experimental Autoimmune Encephalomyelitis, Chronic Macrophage/Microglial Reactivity, and Demyelination in Transgenic Mice Producing Tumor Necrosis Factor-a in Central Nervous System.  Eur. J. Immunol. 1997;27:905-913.
  145. Borson ND, Paul C, Lin X, Nevala WK, Strausbauch MA, Rodriguez M, Wettstein PJ: Brain-Infiltrating Cytolytic T Lymphocytes Specific for Theiler's Virus Recognize H2Db Molecules Complexed with a Viral VP2 Peptide Lacking a Consensus Anchor Residue.  J. Virol. 1997;71:5244-5250.
  146. Hunter SF, Miller DJ, Rodriguez M: Monoclonal Remyelination-Promoting Natural Autoantibody SCH 94.03: Pharmacokinetics and In Vivo Targets within Demyelinated Spinal Cord in a Mouse Model of Multiple Sclerosis.  J. Neurol. Sci. 1997;150:103-113. 
  147. van Engelen BGM, Pavelko KD, Rodriguez M:  Enhancement of Central Nervous system Remyelination in Immune and Non-immune Experimental Models of Demyelination.  Multiple Sclerosis 1997;3:76-79.
  148. Hogancamp WE, Rodriguez M, Weinshenker BG: The Epidemiology of Multiple Sclerosis.  Mayo Clin Proc. 1997;72:871-878. 
  149. Lucchinetti CF, Kimmel DW, Pavelko K, Rodriguez M: 5-Fluorouracil and Levamisole Exacerbate Demyelination in Susceptible Mice Infected with Theiler’s Virus.  Exp. Neurol. 1997;147:123-129.
  150. Njenga MK, Pease LR, Wettstein P, Mak T, Rodriguez M: Interferon  Mediates Early Virus-Induced Expression of H-2D and H-2K in the Central Nervous System. Lab Invest. 1997;77:71-84.
  151. Horwitz MS, Evans CF, McGavern DB, Rodriguez M, Oldstone MBA: Primary Demyelination in Transgenic Mice Expressing Interferon-g.  Nature Med. 1997;3:1037-1041.
  152. Lucchinetti CF, Noseworthy JH, Rodriguez M: Promotion of Endogenous Remyelination in Multiple Sclerosis.  Multiple Sclerosis 1997;3:71-75.
  153. Lassmann H, Bruck W, Lucchinetti C, Rodriguez M: Remyelination in Multiple Sclerosis.  Multiple Sclerosis  1997;3(2): 133-136.
  154. Hogancamp WE, Rodriguez M, Weinshenker BG: Identification of Multiple Sclerosis-Associated Genes.  Mayo Clin. Proc. 1997;72:965-976.
  155. Lucchinetti CF, Kiers L, O'Duffy A, Gomez MR, Cross S, Leavitt JA, O'Brien P, Rodriguez M: Risk Factors for Developing Multiple Sclerosis after Childhood Optic Neuritis.  Neurology 1997;49:1413-1418.
  156. Hunter SF, Leavitt JA, Rodriguez M:  Direct Observation of Myelination In Vivo in the Mature Human Central Nervous System: A Model for the Behavior of Oligodendrocyte Progenitors and their Progeny.  Brain 1997;120:2071-2082.
  157. Njenga MK, Asakura K, Hunter SF, Wettstein P, Pease LR, Rodriguez M: The Immune System Preferentially Clears Theiler’s Virus from the Gray Matter of the Central Nervous System.  J. Virol. 1997;71:8592-8601.
  158. Drescher KM, Pease LR, Rodriguez M: Antiviral Immune Responses Modulate the Nature of Central Nervous System (CNS) Disease in a Murine Model of Multiple Sclerosis.  Immunol. Rev. 1997;159:177-193.
  159. Rodriguez M: Reflexes. IN: Mayo Clinical Examinations in Neurology, Seventh Edition.  David O. Wiebers, Allan J. D. Dale, Emre Kokmen, Jerry W. Swanson, Editors.(Chapter 9):  Mosby Press 1998; pp. 241-254.
  160. Lin X, Sato S, Patick AK, Pease LR, Roos RP, Rodriguez M: Molecular Characterization of a Nondemyelinating Variant of Daniel’s Strain of Theiler’s Virus Isolated from a Persistently Infected Glioma Line.  J. Virol. 1998;72:1262-1269.
  161. Rivera-Quiñones C, McGavern D, Schmelzer JD, Hunter S, Low PA, Rodriguez M: Absence of Neurological Deficits Following Extensive Demyelination in a Class I-deficient Murine Model of Multiple Sclerosis.  Nature Med. 1998;4:187-193.
  162. Petty GW, Engel AG, Younge BR, Duffy J, Yanagihara T, Lucchinetti CF, Bartleson JD, Parisi JE, Kasperbauer JL, Rodriguez M: Retinocochleocerebral Vasculopathy. Medicine 1998;77:12-40.
  163. Pavelko KD, Van Engelen BGM, Rodriguez M: Acceleration in the Rate of CNS Remyelination in Lysolecithin-Induced Demyelination.  J. Neurosci. 1998;18(7): 2498-2505.
  164. Drescher KM, Nguyen LT, Taneja V, Coenen MJ, Leibowitz J, Strauss G, Hammerling GJ, David CS, Rodriguez M:  Expression of the Human Histocompatibility Leukocyte Antigen DR3 Transgene Reduces the Severity of Demyelination in a Murine Model of Multiple Sclerosis.  J. Clin. Invest. 1998;101:1765-1774.
  165. Bureau JF, Drescher KM, Pease LR, Vikoren T, Del Croix M, Brachic M, Rodriguez M: Chromosome 14 Contains Determinants that Regulate Susceptibility to Theiler's Virus-induced Demyelination in the Mouse.  Genetics. 1998;148:1941-1949.
  166. Stolp-Smith KA, Atkinson EJ, Campion ME, O’Brien P, Rodriguez M: Health Care Expenditure by People with Multiple Sclerosis in Olmsed County, MN: A Population-based Study 1989-1993.  Neurology 1998; 50:1594-1600.
  167. Lin X, Pease LR, Rodriguez M: Theiler’s Virus Infection of Genetically Susceptible Mice Induces CNS-Infiltrating Cytotoxic T Lymphocytes without Apparent Viral or Major Myelin Antigenic Specificity.  J. Immunol. 1998; 160:5661-5668.
  168. Asakura K, Rodriguez M: Immunoglobulin-mediated Central Nervous system Remyelination.  Neurological Therapeutics (Japan)  1998;15:245-250.                     
  169. Drescher KM, Rivera-Quinones C, Lucchinetti CF, Rodriguez M: Failure of Treatment with Linomide on Oral Myelin Tolerization to Ameliorate Demyelination in a Viral Model of Multiple Sclerosis.  J. Neuroimmunol. 1998;88:111-119.
  170. Murray P, Pavelko K, Leibowitz J, Rodriguez M: CD4+ and CD8+ T Cells Make Discrete Contributions to Demyelination and Neurologic Disease in a Viral Model of Multiple Sclerosis.  J. Virol. 1998;72:7320-7329.
  171. Asakura K, Rodriguez M: A Unique Population of Circulatory Autoantibodies Promote Central Nervous system Remyelination.  Multiple Sclerosis 1998;4:217-221.
  172. Weinshenker BG, Santrach P, Bissonett AS, McDonnell SK, Schaid D, Moore SB, Rodriguez M: Major Histocompatibility Complex Class II Alleles are not Strongly Associated with the Course and Outcome of Multiple Sclerosis: A Population-Based Study.  Neurology 1998;51:742-747.
  173. Murray P., Lin X, Njenga MK, Leibowitz J, Pease LR, Rodriguez M: Perforin-Dependent Neurologic Injury in a Viral Model of Multiple Sclerosis.  J. Neuroscience 1998;18:7306-7314.
  174. Lucchinetti CF, Brück W, Rodriguez M, Lassmann H: Multiple Sclerosis: Lessons from Neuropathology.  Seminars in Neurology. 1998;18(3): 337-349.
  175. Dodick D., Silber M, Noseworthy J, Willbright W, Rodriguez M: Acute Disseminated Encephalomyelitis after Accidental Injection of a Hog Vaccine: Successful Treatment with Plasmapheresis.  Mayo Clin. Proc. 1998;73:1193-1195.
  176. Asakura K, Miller DJ, Pease, LR, Rodriguez M: Targeting of IgMk Antibodies to Oligodendrocytes Promotes Central Nervous System Remyelination.  J. Neurosci. 1998;18:7700-7708.
  177. Renno T, Taupin V, Bourbonnière L, Verge G, Tran E, de Simone R, Kaprowski M, de Simone R, Rodriguez M, Peterson A, Owens T: Interferon-gamma in Progression to Chronic Demyelination and Neurological Deficits following Acute EAE.  Mol. Cell. Neurosci. 1998;12:376-389.
  178. Asakura K, Suzumura A, Rodriguez M, Sawada M: Differentiation-Specific mRNA Expression of a Mouse Bipotential Glial Cell Line.  Neuroscience: 1998;258:21-24.
  179. Lin X, Roos RP, Pease LR, Wettstein P, Rodriguez M: A Theiler’s Virus Alternatively-Initiated Protein Inhibits the Generation of H-2K-Restricted Virus-Specific Cytotoxicity.  J. Immunol.1999162:17-24.
  180. Wright RA, O'Duffy JD, Rodriguez M: Improvement of myelopathy in Sjögren's Syndrome with Chlorambucil and Prednisone Therapy.  Neurology.1999; 52:386-388.
  181. Drescher KM, Murray PD, David CS, Pease LR, Rodriguez M: CNS Cell Populations are protected from Virus-Induced Pathology by Distinct Arms of the Immune System.  Brain Path. 1999;9:21-31.
  182. McGavern D, Asakura K, Rodriguez M: Do Antibodies Stimulate Myelin Repair in Multiple Sclerosis?  The Neuroscientist 1999;5:19-28.
  183. Njenga KM, Murray P, McGavern D, Lin X, Drescher K, Rodriguez M.  Absence of Spontaneous Central Nervous System Remyelination in Major Histocompatibility Complex Class-II-Deficient Mice Infected with Theiler’s Virus.  J. Neuropath. Exp. Neurol. 1999;58:78-91.
  184. Bright JJ, Rodriguez M, Sriram S:  Differential Influence of IL-12 in the Pathogenesis of Autoimmune and Virus-induced CNS Demyelination.  J. Virol. 1999;73:1637-1639.
  185. Johnson AJ, Njenga MK, Hansen MJ, Kuhns ST, Chen L, Rodriguez M, Pease LR: Prevalent Class I-restricted T Cell Response to the Theiler's Virus Epitope Db:VP2121-130 in the Absence of Endogenous CD4 Help, TNFa, IFN-g, Perforin or Co-stimulation through CD28.  J. Virol. 1999;73(5): 3702-3708.
  186. Goodin DS, Ebers GC, Johnson KP, Rodriguez M, Sibley WA, Wolinsky JS: The Relationship of MS to Physical Trauma and Psychological Stress.  Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.  Neurology 1999;52:1737-1745.
  187. O'Neill BP, Habermann TM, Witzig TE, Rodriguez M: Pilot Results of Biologic Therapy in Primary Central Nervous System Lymphoma (PCNSL); Prevention of Recurrence and Prolonged Survival in High Risk Patients with Adjuvant High Dose Methylprednisolone.  Medical Oncology 1999;16:211-215.
  188. McGavern DB, Zoecklin L, Drescher KM, Rodriguez M: Quantitative Assessment of Neurologic Deficits in a Chronic Progressive Murine Model of CNS Demyelination.  Exp. Neurol. 1999;158:171-181.
  189. Watanabe R, Asakura K, Rodriguez M, Pagano R: Internalization and Sorting of Plasma Membrane Sphingolipid Analogs in Differentiating Oligodendrocytes.  J. Neurochem. 1999;73:1375-1383.
  190. McGavern DB, Murray PD, Rodriguez M: Quantitation of Spinal Cord Demyelination, Remyelination, Atrophy and Axonal Loss in a Model of Progressive Neurologic Injury.  J. Neurosci. Res .1999;58:492-504.
  191. Rodriguez M, Lucchinetti CF: Is apoptotic Death of the Oligodendrocyte a Critical Event in the Pathogenesis of Multiple Sclerosis?  Neurology 1999;53(8): 1615-1616.
  192. Stolp-Smith KA, Atkinson EJ, Campion ME, O'Brien PC, Rodriguez M: Health Care Utilization in MS - Reply.  Neurology. 1999;53(4): 893.
  193. Weinshenker BG, O'Brien PC, Petterson TM, Noseworthy JH, Lucchinetti C, Dodick PW, Pineda AA, Stevens LN, Rodriguez M:  A Randomized Trial of Plasma Exchange in Acute Central Nervous System Inflammatory Demyelinating Disease.  Ann. Neurol. 1999;46:878-886.
  194. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H: A Quantitative Analysis of Oligodendrocytes in Multiple Sclerosis Lesions: A Study of 113 Cases.  Brain. 1999;122:2279-2295. 
  195. Drescher KM, Zoecklein L, Rivera-Quiñones C, Hollenbaugh D, Rodriguez M: C40L is Critical for Protection from Demyelinating Disease and Development of Spontaneous Remyelination in a Mouse Model of Multiple Sclerosis.  Brain Path. 2000;10:1-15.
  196. Njenga KM, Coenen M, Decuir N, Rodriguez M: Short Term Treatment with Interferon a/b Promotes Remyelination Whereas Long Term Treatment Aggravates Demyelination in a Murine Model of Multiple Sclerosis.  J. Neurosci. Res. 2000;59:661-670.
  197. Das P, Drescher KM, Bradley DS, Rodriguez M, David CS: Complementation Between Specific HLA-DR and HLA-DQ Genes in Transgenic Mice Determines Susceptibility to Experimental Autoimmune Encephalomyelitis.  Human Immunology 2000;61:279-289.
  198. McGavern DB, Murray PD, Rivera-Quiñones C, Schmelzer JD, Low PA, Rodriguez M: Axonal Loss Results in Spinal Cord Atrophy, Electrophysiologic Abnormalities, and Neurologic Deficits Following Demyelination in a Chronic Inflammatory Model.  Brain 2000;123:519-531.
  199. Drescher KM, Johnston SL, Hogancamp W, Nabozny GH, David CS, Rimm IJ, Wettstein PJ, Rodriguez M: Vb8+ T Cells Protect from Demyelinating Disease in a Viral Model of Multiple Sclerosis.  Int. Immunol. 2000;12:271-280.
  200. Drescher KM, Murray PD, Lin X, Carlino JA, Rodriguez M:  TGF-b2 Reduces Demyelination, Virus Antigen Expression and Macrophage Recruitment in a Viral Model of Multiple Sclerosis.  J. Immunol. 2000;164:3207-3213.
  201. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H: Heterogeneity of Multiple Sclerosis Lesions: Implications for the Pathogenesis of Demyelination.  Ann Neurol. 2000;47:707-717.
  202. Warrington AE, Asakura K, Bieber A, Ciric B, Van Keulen V, Kaveri SV, Kyle R, Weinshenker B, Pease L, Rodriguez M: Human Monoclonal Antibodies Promote Remyelination of Spinal Cord Lesions in a Model of Multiple Sclerosis.  2000;PNAS 97:6820-6825.
  203. Murray PD, Krivacic K, Chernosky A, Ransohoff RM, Rodriguez M: Biphasic and Regionally-restricted Chemokine Expression in the Central Nervous System in the Theiler’s Virus Model of Mulitple Sclerosis.  J. Neurovirol.6: 2000;Supplement 1, S44-S52.
  204. Pavelko KD, Drescher KM, McGavern DB, David CS, Rodriguez M: HLA-DQ Polymorphism Influences Progression of Demyelination and Neurologic Deficits in a Viral Model of Multiple Sclerosis.  Mol. Cell. Neurosci. 2000;15:495-509.
  205. Scarisbrick IA, Asakura M, Blaber S, Isackso, PJ, Bieto T, Rodriguez M, Windebank AJ: Preferential Expression of Myeloencephalon Specific Protease by Oligodendrocytes of the Adult Rat Spinal Cord White Matter.  2000;Glia 30:219-230.
  206. Kimura K, Hunter SF, Thollander MS, Loftus EV, Melton J, O'Brien P, Rodriguez M, Phillips SF: Concurrence of Inflammatory Bowel Disease and Multiple Sclerosis.  Mayo Clinic. Proc. 2000;75:802-806.
  207. Ure D, Rodriguez M: Extensive Injury of Descending Neurons Demonstrated by Retrograde labeling in a Virus-induced Murine Model of Chronic Inflammatory Demyelination.  J. Neuropath. Exp. Neurol. 2000;59:664-678.
  208. Wingerchuk, D, Nyquist P, Rodriguez M, Dodick DW: Extratrigeminal short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT): new pathophysiologic entity or variation on a theme?  Cephalgia 2000;20(2): 127-129.
  209. Noseworthy JH, O'Brien PC, Weinshenker BG, Weiss JA, Petterson TM, Windebank AJ, Whisnant JP, Stolp-Smith KA, Harper CM, Low PA, Romme LJ, Johnson M, An KN, Rodriguez M: IV Immunoglobulin does not Reverse Established Weakness in MS: A Double-Blind, Placebo-Controlled Trial.  Neurology 2000;55:1135-1143.
  210. Rodriguez M, Roos R, Zoecklein L, Pavelko K, McGavern D, Sang H, Lin X: The CD4-Mediated Immune Response is Critical in Determining the Outcome of Infection using Theiler's Viruses with VP1 Capsid Point Mutations.  Virology 2000;275:9-19.
  211. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG: Multiple Sclerosis (Medical Progress).  New Eng. J. of Med.2000;343:938-952.
  212. Sathornsumetee S, McGavern DB, Ure DR, Rodriguez M: Quantitative Ultrastructural Analysis of a Single Spinal Cord Demyelinated Lesion Predicts Total Lesion Load, Axonal Loss, and Neurological Dysfunction in a Murine Model of Multiple Sclerosis.  Am. J. Pathol. 2000;157:1365-1376.
  213. McGavern DB, Zoecklein L, Sathornsumetee S, Rodriguez M:  Assessment of Hindlimb Gait as a Powerful Indicator of Axonal Loss in a Murine Model of Progressive CNS Demyelination.  Brain Res. 2000;877:396-400.
  214. Scarisbrick IA, Asakura K, Rodriguez M: Neurotrophin-4/5 Promotes Proliferation of Oligodendrocyte-Type 2 Astrocytes (0-2A).  Developmental Brain Res. 2000;123:87-90.
  215. Bieber A, Asakura K, Warrington A, Kaveri SV, Rodriguez M: Antibody-mediated Remyelination: Relevance to Multiple Sclerosis.  Multiple Sclerosis 6(Suppl2): 2000;51-55.
  216. Wright RA, O’Duffy JD, Rodriguez M: Improvement of Myelopathy in Sjögren’s Syndrome with Chlorambucil and Prednisone Therapy.  Neurology  1999;52:386-388.
  217. Ciric B, Van Keulen V, Rodriguez M, Kyle RA, Gertz MA, Pease LR: Clonal Evolution in Waldenstrom's Macroglobulinemia Highlights Functional Role of B Cell Receptor.  Blood. 2001: 97(1):321-323.
  218. Cameron K, Zhang T, Seal B, Rodriguez M, Njenga MK: Antigens to Viral Capsid and Non-Capsid Proteins are Present in Brain Tissues and Antibodies in Sera of Theiler's Virus Infected Mice. J. Virol. Meth. 2001;91:11-19.
  219. Scarisbrick IA, Isackson PJ, Ciric B, Windebank AJ, Rodriguez M: MSP, a Trypsin-like Serine Protease is Abundantly Expressed in the Human Nervous System.  J. Comp. Neurol. 2001;431:347-361.
  220. Noseworthy JH, O'Brien PC, Peterson TM, Weiss J, Stevens L, Peterson WK, Sneve D, Cross, SA, Leavitt JA, Auger RG, Weinshenker BG, Beck RW, Rodriguez M: A Randomized Trial of Intravenous Immunoglobulin in Inflammatory Demyelinating Optic Neuritis.  Neurology 2001;56:1514-1522.
  221. Murray PD, McGavern DB, Sathornsumetee S, Rodriguez M: Spontaneous Remyelination Following Extensive Demyelination in Association with Improved Neurologic Function in a Viral Model of Multiple Sclerosis.  Brain.  2001;124:1403-1416.
  222. Ure DR, McGavern DB, Sathornsumetee S, Rodriguez M: The Contribution of Axonal Injury to Neurologic Dysfunction in Theiler's Virus-Induced Inflammatory Demyelinating Disease In: Genes and Viruses in Multiple Sclerosis.  Editors, O. R. Hommes, M. Clanet, H. Wekerle.  Elsevier Science B.V., Amsterdam.(Chapter 10): 2001; pp. 78-88.
  223. Rodriguez M: Remyelination - Proceedings of the MS Forum Modern Management Workshop, Athens, March 2000, Pathology and Clinical Feature of Multiple Sclerosis.  MS Forum,(Chapter 6):2001; pp. 21-25.
  224. Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu Y-X, Chen L: Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Ea-Transgenic Mice.  J. Immunol. 2001;167:2671-2676.
  225. Warrington AE, Bieber AJ, Ciric B, Van Keulen V, Pease LR, Mitsunaga Y, Paz Soldan M, Rodriguez M: Immunoglobulin-mediated CNS Repair.  J. Allergy Clin. Immunol. 2001;108:S121-125.
  226. Bieber AJ, Warrington A, Pease LR, Rodriguez M: Humoral Autoimmunity as a Mediator of CNS Repair. Trends Neurosci 2001; 24:S39-S44.
  227. Nyquist PA, Cascino G, Rodriguez M: Seizures in Patients with Multiple Sclerosis in Rochester, Minnesota, 1990 - 1998.  Mayo Clin. Proc. 2001;76:983-986.
  228. Johnson AJ, Upshaw J, Pavelko KP, Rodriguez M, Pease LR: Preservation of Motor Function by Inhibition of CD8+ Virus-peptide Specific T Cells in Theiler's Virus Infection.  FASEB J. 2001;15(12): 255-276.
  229. Matsumoto J, Morrow D, Kaufman K, Davis D, Ahlskog JE, Walker A, Sneve D, Noseworthy J, Rodriguez M: Surgical Therapy for Tremor in Multiple Sclerosis: An evaluation of outcome measures.  Neurology 2001;57:1876-1882.
  230. Pittock SJ, Rodriguez M, Wijdicks FM: Rapid Weaning from Mechanical Ventilator in Acute Cervical Cord Multiple Sclerosis Lesion after Steroids.  Anesthesia Analgesia 2001;93(6):1550-1551.
  231. Keegan M, Pineda A, Rodriguez M, Weinshenker B: Plasma Exchange for Severe Attacks of CNS Demyelination: Predictors of Response.  Neurology 2002;58:143-146.
  232. Bieber AJ, Warrington A, Van Keulen V, Ciric B, Pease L, Rodriguez M: Antibody-mediated Remyelination in Brain Disease: Therapeutic Strategies and Repair.  Edited by O. Abransky, A. Compston, A. Miller and G. Said (Chapter 5):2002; pp. 37-43.
  233. Blaber SI, Scarisbrick IA, Bernett MJ, Dhanarajan P, Seavy MA, Jin Y, Schwartz MA, Rodriguez M, Blaber M: Enzymatic Properties of Rat Myelencephalon-Specific Protease.  Biochemistry 2002;41:1165-1173.
  234. Ransohoff  RM, Wei T, Pavelko KD, Murray PD, Rodriguez M: Chemokine Expression in the Central Nervous System of Mice with a Viral Disease Resembling Multiple Sclerosis: Roles of CD4+ and CD8+ T Cells and Viral Persistence.  J. Virol. 2002;76:2217-2224.
  235. Murray PD, McGavern DB, Pease LR, Rodriguez M: Cellular Sources and Targets of IFNg-mediated Protection against Viral Demyelination and Neurologic Deficits.  Eur. J. Immunol. 2002;32:606-615.
  236. Bieber AJ, Warrington A, Asakura K, Ciric B, Kaverni SV, Pease L, Rodriguez M:  Human Antibodies Accelerate the Role of Remyelination following Lysolecithin-induced Demyelination in Mice.  2002;Glia 37(3): 241-249.
  237. Mitsunaga Y, Ciric B, Van Keulen V, Warrington A, Paz Soldan M, Bieber A, Rodriguez M, Pease L.  Direct Evidence that a Human Antibody Derived from Patient Serum Can Promote Myelin Repair in a Mouse Model of Chronic-Progressive Demyelinating Disease.  J. FASEB. 2002;16:1325-1327.
  238. Mayr WT, Rodriguez M: Multiple Sclerosis Update.  Minnesota Medicine 2002;85:36-3902.
  239. Wilcox, R.A., Flies, D.B., Wang, H., Tamada, K., Johnson, A.J., Pease, L.R., Rodriguez M., Guo, Y., Chen, L.  Impaired Infiltration of Tumor-specific Cytolytic T Cells in the Absence of Interferon-g Despite Their Normal Maturation in Lymphoid Organs During CD137 Monoclonal Antibody Therapy.  Cancer Research. 2002: 62: 4413-4418.
  240. Lin X, Kariuki Njenga M, Pavelko KD, Johnson AJ, David CS, Pease LR, Rodriguez M: Transgenic Expression of Theiler's Murine Encephalomyelitis Virus (TMEV) Genes in H-2b Mice Abrogates Resistance to Virus-induced Demyelination.  J. Virol. 2002;76:7799-7811.
  241. Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M: Activity of a Newly Identified Serine Protease in Immune-mediated Demyelination.  Brain. 2002;  25:1283-1296.
  242. Nyquist PA, Cascino GP, McClelland RL, Annegers FJ, Rodriguez M: Incidence of Seizures in Patients with Multiple Sclerosis: A Population-based Study.  Mayo Clin. Proc. 2000; 77:910-912.
  243. Ure D, Rodriguez M: Polyreactive Antibodies to Glatiramer Acetate Promote Myelin Repair in Murine Model of Demyelinating Disease.  J. FASEB. 2002;16:1260-1262.
  244. Ransohoff RM, Howe CL, Rodriguez M: Growth factor treatment of demyelinating disease; at last, a leap into the light.  Trends in Immunology.  2002;23:512-516.
  245. Ure DR, Rodriguez M: Preservation of Neurologic Function during Inflammatory Demyelination Correlates with Axon sparing in a Mouse Model of Multiple Sclerosis.  Neuroscience.  2002;111(2) 399-411.
  246. Paz Soldan MM, Rodriguez M:  Heterogeneity of Pathogenesis in Multiple Sclerosis: Implications for Promotion of Remyelination.  J. Infect. Dis., Supplement. 2002;186:S248-S253.
  247. Drescher KM, Zoecklein L, Rodriguez M: ICAM-1 is Crucial for Protection from TMEV-induced Neuronal Damage but not Demyelination.  J. Neurvirol. 2002; 8:452-458.
  248. Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T, Pardoll DM, Chen L, Rodriguez M, Pease LR: Cross-linking B7 Family Molecule B7-DC Directly Activates Immune Function of Dendritic Cells.   J. Exp. Med 2002; 196(10): 1393-1398.
  249. Pavelko KD, Drescher KD, Gamez JD, Wei T, Ransohoff RM, Rodriguez M: Interleukin 6 Protects Anterior Horn Neurons from Lethal Virus-induced Injury.  J. Neurosci. 2003; 23:481-492.
  250. Paz Soldan MM, Warrington AE, Bieber AJ, Ciric B, Van Keulen V, Pease LR, Rodriguez M: Remyelination Promoting Antibodies Activate Distinct Ca++ Influx pathways in Astrocytes and Oligodendrocytes: Relationship to the Mechanism of Myelin Repair.  Molecular and Cellular Neuroscience.  2003;22:14-24.
  251. Scarisbrick IA, Rodriguez M: Hit-Hit and Hit-Run: Viruses in the Playing Field of Multiple Sclerosis.  Current Neurology and Neuroscience Reports. 2003; 3(3): 265-271.
  252. Rodriguez M: A Function of Myelin is to Protect Axons form Subsequent Injury: Implication for Deficits in MS.  Brain. 2003;126:751-752.
  253. Khare M, Rodriguez M, David CS.  HLA Class II Transgenic Mice Authenticate Restriction of Myelin Oligodendrocyte Glycoprotein-Specific Immune Response Implicated in Multiple Sclerosis Pathogenesis.   International Immunology. 2003;15(4): 535-546.
  254. Alley T, Khasabou S, Simone D, Beitz A, Rodriguez M, Njenga MK: More Severe Neurologic Deficits in Male SJL/J Mice than Female Mice Following Theiler's Virus Infection.  Exp. Neurol, 2003;180(1): 14-24.
  255. Bieber AJ, Kerr S, Rodriguez M: Efficient CNS Remyelination Requires T-cells.  Annals of Neurology. 2003; 53:680-684.
  256. Pirko I, Kuntz NL, Keegan M, Weinshenker BG, Patterson M, Rodriguez M: Contrasting Effects of IFN B and IVIg in Children with Central and Peripheral Demyelination.  Neurolog. 2003; 60:1697-1699.
  257. Zoecklein LJ, Pavelko KD, Gamez J, Papke L, McGavern DB, Ure DR, Njenga MK, Johnson AJ, Nakane S, Rodriguez M: Direct Comparison of Demyelinating Disease Induced by the Daniel’s Strain and BeAn Strain of Theiler’s Murine Encephalomyelitis Virus.  Brain Pathology. 2003; 13:291-308.
  258. Pirko I, Ciric B, Johnson AJ, Gamez J, Rodriguez M, Macura S: Magnetic Resonance Imaging of Immune Cells in Inflammation of Central Nervous System.  Croatian Medical Journal.  2003;44(4): 463-468.
  259. Rodriguez M: The Complexity of Oligodendrocyte-Myelin-Axon Injury in Multiple Sclerosis. Esclerosis Múltiple. , 2003;1(1): 20-25.
  260. Lin X, Ma X, Rodriguez M, Feng X, Zoecklein L, Fu Y, Roos RP: Membrane Lymphotoxin Is Required for Resistance to Theiler’s Virus Infection.  International Immunology. 2003;  15(8): 955-962.
  261. Mendez-Fernandez YV, Johnson AJ, Rodriguez M, Pease LR: Clearance of Theiler's virus infection depends on the ability to generate a CD8+ T cell response against a single immunodominant viral peptide.  European Journal of Immunolog., 2003; 33(9): 2501-10.
  262. Rodriguez M, Zoecklein LJ, Howe CL, Pavelko KD, Gamez JD, Nakane S, Papke LM: Gamma Interferon is Critical for Neuronal Viral Clearance and Protection in a Susceptible Mouse Strain Following Early Intracranial Theiler’s Murine Encephalomyelitis Virus Infection.  Journal of Virology.  2003; 77(22): 12252-12265.
  263. Mayr WT, Pittock S, McClelland R, Jorgensen NW, Noseworthy J, Rodriguez M: Incidence and Prevalence of Multiple Sclerosis in Olmsted County, Minnesota 1985-2000.  Neurology. 2003;61(10): 1373-1377.
  264. Ciric B, Howe CL, Warrington AE, Bieber AJ, Van Keulen V, Paz Soldan M, Rodriguez M, Pease LR: Human Monoclonal IgM Antibody Promotes CNS Myelin Repair Independent of Fc Function.  Brain Pathology. 2003;13:608-616.
  265. Nakane S, Zoecklein L, Gamez JD, Papke L, Pavelko KD, Bureau JF, Brahic M, Pease LR, Rodriguez M:  A 40 cm Region on Chromosome 14 Plays a Critical Independent Role in the Development of Virus Persistence, Demyelination, Brain Pathology and Neurologic Deficits in a Murine Viral Model of Multiple Sclerosis.  Brain Pathology.  2003;13:519-533.
  266. Pirko I, Gamez J, Johnson AJ, Macura SI, Rodriguez M: Dynamics of MRI Lesion Development in an Animal Model of Viral-induced Progressive CNS Demyelination.  NeuroImage.  2003;21(2): 576-582.
  267. Pirko I, Johnson A, Ciric B, Gamez J, Macura S, Pease LR, Rodriguez M: In Vivo Magnetic Resonance Imaging of Immune Cells in the Central Nervous System with Superparamagnetic Antibodies.  FASEB Journal. 2004;Jan;18(1):179-82.
  268. Pittock SJ, Mayr WT, McClelland RL, Jorgensen NW, Weigand SD, Noseworthy J, Rodriguez M: Change in MS related disability in a population-based cohort; a ten-year follow-up study.  Neurology. 2004; 62:51-59.
  269. Pirko I, Johnson A, Gamez J, Macura SI, Rodriguez M: Disappearing “T1 Black Holes” in an Animal Model of Multiple Sclerosis.  Frontiers in Bioscience, 2004;9:1222-1227.
  270. Mangalam AK, Khare M, Krco C, Rodriguez M, David C: Identification of T Cell Epitopes on Human Proteolipid Protein and Induction of Experimental Autoimmune Encephalomyelitis in HLA Class II Transgenic Mice.  European Journal of Immunology, 2004; 34:280–290.
  271. Kumar N, Rodriguez M: Scleromyxedema in a Patient with Multiple Sclerosis and Monoclonal Gammopathy on Interferon beta-1a.  Journal of Multiple Sclerosis, 2004.  10:85-86.
  272. Njenga MK, Marques C, Rodriguez M.  The role of cellular immune response in Theiler’s virus-induced central nervous system demyelination.  J. Neuroimmunol, 2004.  147:73-77.
  273. Howe CL, Bieber AJ, Warrington AE, Pease LR, Rodriguez M:  Anti-apoptotic signaling by a remyelination-promoting human anti-myelin antibody.  Neurobiology of Disease,2004; 15:120-131.
  274. Pittock SJ, Mayr WT, McClelland RL, Jorgensen NW, Weigand SD, Noseworthy J, Rodriguez M:  Disability profile of MS Did Not Change over 10 years in a Population-based Prevalence Cohort.  Neurology, 2004.  62:601-606.
  275. Kantarci OH, Hebrink DD, Achenbach SJ, Pittock S, Altintas A, Schaefer-Klein JL, Atkinson EJ, de Andrade M, McMurray CT, Rodriguez M, Weinshenker BG: Association of apoE polymorphisms with disease severity in MS is limited to women. Neurology, 2004.  62:811-814.
  276. Ciric B, Van Keulen V, Paz Soldan M, Rodriguez M, Pease LR: Antibody-Mediated Remyelination Operates Through Mechanism Independent of Immunomodulation.  J. Neuroimmunology, 2004.  146:153-161.
  277. Blaber SI, Ciric B, Christophi GP, Bernett MJ, Blaber M, Rodriguez M, Scarisbrick IA: Targeting Kallikrein 6-Proteolysis Attenuates CNS Inflammatory Disease.  FASEB, 2004.  FASEB Journal express article 10.1096/fj.03-1212fje online., Mar: 18(3):316-340
  278. Hoftberger R, Aboul-Enein F, Ploegh HL, Brueck W, Lucchinetti C, Rodriguez M, Schmidbauer M, Jellinger K, Lassmann H: Expression of Major Histocompatibility Complex Class I Molecules on the Different Cell Types in Multiple Sclerosis Lesions.  Brain Pathology, 2004.  14(1): 43-50.
  279. Warrington AE, Bieber AJ, Van Keulen V, Ciric B, Pease LR, Rodriguez M: Neuron-Binding Human Monoclonal Antibodies Support Central Nervous System Neurite Extension.  J. Neuropath. Exp. Neurology, 2004.  63(5): 461-473.
  280. Pittock SJ, Mayr WT, McClelland RL, Jorgensen NW, Weigand SD, Noseworthy J, Rodriguez M: Quality of Life is Favorable for Most Patients With Multiple Sclerosis.  A Population-based Cohort Study.  Archives of Neurology, 2004; 61(5):679-686.
  281. Pittock SJ, Mayr WT, McClelland RL, Jorgensen NW, Weigand SD, Noseworthy J, Rodriguez M : Clinical implications of benign Multiple Sclerosis: a 20 year Population-Based Follow-up Study.   Annals of Neurology, 2004;56(2):303-306.
  282. Pirko I, Ciric B, Gamez J, Bieber AJ, Warrington AE, Johnson AJ, Hanson DP, Pease LR, Macura SI, Rodriguez M: A Human Antibody That Promotes Remyelination Enters the CNS and Decreases Lesion Load as Detected by T2 Weighted Spinal Cord MRI in a Virus-Induced Murine Model of MS.  FASEB J, 2004; 18: 1577-1579.
  283. Lin X, Ma X, Rodriguez M, Roos RP: CD4+ T Cells are Important for Clearance of DA Strain of TMEV from the Central Nervous System of SJL/J Mice.  International Immunology, 2004;16(9):1237-1240.
  284. Christophi GP, Isackson PJ, Blaber S, Blaber M, Rodriguez M, Scarisbrick IA: Distinct Promoters Regulate Tissue-Specific and Differential Expression of Kallikrein 6 in CNS Demyelinating Disease.  Journal of Neurochemistry. 2004;91:1439–1449.
  285. Nelson ALA, Bieber AJ, Rodriguez M: Contrasting Murine Models of MS.  Int MS J., 2004; Dec; 11(3):95-9.
  286. Pittock SJ, McClelland RL, Mayr WT, Rodriguez M,  Matsumoto JY.Prevalence of tremor in multiple sclerosis and associated disability in the Olmsted County Population. Movement Disorders, 2004: 19:1482-1485.
  287. Rahimi RA, Rodriguez M. New drugs from old: attenuating neuroninflammation, neuronal injury, and demyelination with semi-synthetic tetracycline derivatives. Current Trends in Immunology, 2004; 6:57-67.
  288. Bieber AJ, Ure DR, Rodriguez M:  Genetically Dominant Spinal Cord Repair in a Murine Model of Chronic Progressive Multiple Sclerosis.  J. Neuropathology and Experimental Neurology, 2005; 64(1):46-57.
  289. Block, MS, Mendez-Fernandez YV, Van Keulen VP, Hansen MJ, Allen KS, Taboas AL, Rodriguez M, Pease LR: Inability of bm14 mice to respond to TMEV is caused by defective antigen presentation, not repertoire selection.   J. Immunolog. ,2005 Mar 1;174(5):2756-62.
  290. Mendez-Fernandez YV, Hansen MJ, Rodriguez M, Pease LR.  Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.  J. Virol,  2005; Mar;79(5):3063-70.
  291. Pirko I, Fricke ST, Johnson AJ, Rodriguez M, Macura SI. Magnetic Resonance Imaging, Microscopy, and Spectroscopy of the Central Nervous System in Experimental Animals.  NeuroRx  2005;2:250-264.
  292. Wingerchuk DM, Benarroch EE, O’Brien PC, Keegan BM, Lucchinetti CF, Noseworthy JH, Weinshenker BG, Rodriguez M: A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis.  Neurology, 2005. 64:1267-1269.
  293. Mangalam AK, Khare M, Krco CJ, Rodriguez M, David CS: Delineation of the minimal encephalitogenic epitope of proteolipid protein peptide91-110 and critical residues required for induction of EAE in HLA-DR3 transgenic mice.  J. Neuroimmunology, 2005; 161:40-48
  294. Ure DR, Lane TE, Rodriguez M: Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler’s virus infection. International Immunology 2005;17(5):569-579.
  295. Johnson AJ, Mendez-Fernandez Y, Moyer AM, Sloma CR, Pirko I, Block MS, Rodriguez M, Pease LR: Antigen-Specific CD8+ T-Cells Mediate a Peptide-Induced Fatal Syndrome.   J. Immunol. 2005;174:6854-6862.
  296. Keegan M, Konig F, McClelland R, Bruck W, Morales Y, Bitsch A, Panitch H, Lassmann H, Weinshenker B, Rodriguez M, Parisi J, Lucchinetti CF. Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange.Lancet 2005 Aug 13-19; 366(9485):579-82.
  297. Khare M, Mangalam A, Rodriguez M, David CS: HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice.  J Neuroimmunol. 2005: 169:1-12.
  298.  Pittock SJ, McClelland RL, Achenback SJ, Konig F, Bitsch A, Bruck W, Lassmann H, Parisi JE, Scheithauer BW, Rodriguez M, Weinshenker BG, Lucchinetti.  Clinical course, pathologic correlations and outcome of biopsy proven inflammatory demyelinating disease.  Journal of Neurology, Neurosurgery and Psychiatry 2005: 76:1693-1697.
  299.  Van Keulen, VP, Ciric B, Radhakrishnan S, Heckman KL, Mitsunaga Y, Lijima K, Kita H, Rodriguez M, Pease LR. Immunomodulation using the Monoclonal human B7-DC Cross-linking Antibody rHIgM12. Clinical and Experimental Immunology 2006; 143:314-321.
  300.  Rodriguez, M Zoecklein L, Gammez J, Pavelko KD,  Papke LM, Nakane S, Howe C, Radhakrishnan  S, Hansen MJ, David CS, Warrington AE, Pease LR. STAT4 and STAT6 Signaling Molecules in a Murine Model of Multiple Sclerosis. FASEB J 2006;20:343-345.
  301. Nance CS, Desnick RJ, Banikazemi M, Dikman SH, Phelps RG, Rodriguez M, Klein CJ. Later-Onset Fabry Disease: An Adult Variant Presenting with Cramp Fasciculations.  Archives of Neurology, 2006; 63:453-457.
  302. Pittock SJ , Weinshenker BG , Noseworthy JH , Lucchinetti CF , Keegan M , Wingerchuk DM , Carter J , Shuster E  Rodriguez M.  Not Every Patient with Multiple Sclerosis Should Be Treated at Time of Diagnosis.  Archives of Neurology, 2006; 63:611-614.
  303. Pittock SJ, Rodriguez M:  Disability in Multiple Sclerosis. Is MS a more benign condition than previously supposed? Esclérosis Múltiple, 2006; 1(1):12-22.
  304. Howe CL, Mayoral SR, Rodriguez M. Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β. Neurobiol Dis, 2006; 23:731-739.
  305. Scarisbrick, I.A., S.I. Blaber, J.T. Tingling, M. Rodriguez, M. Blaber, and G.P. Christophi. Potential scope of action of tissue kallikreins in CNS immune-mediated disease. J. Neuroimmunology 2006; 178:167-176.
  306.       Wingerchuk DM, Rodriguez M: Premenstrual multiple sclerosis pseudoexacerbations: Role of body temperature and prevention with aspirin. Archives of Neurology 2006; 63:1005-1008.
  307. Scarisbrick IA, Sabharwal P, Blaber S, Cruz H, Ameenuddim S, Papke LM, Larsen N, Fehlings MG, Reeves RK, Blaber M, Windebank AJ, Rodriguez M.  Dynamic Role of Kallikrein 6 in Traumatic Spinal Cord Injury. Eur J of Neurosci 2006; 24:1457-1469.
  308. Buenz EJ, Rodriguez M,  Howe CL. Disrupted Spatial Memory is a Consequence of Picornavirus Infection. Neurobiol 2006: 24(2):266-273.
  309. Miller RC, Lachance DH, Lucchinetti CF, Keegan BM, Gavrilova RH, Brown PD, Weinshenker BG, Rodriguez M. Multiple Sclerosis, Brain Radiotherapy, and Risk of Neurotoxicity: The Mayo Clinic Experience. Int J Radiat Oncol Biol Phys 2006;66:1178-1186
  310. Mangalam AK, Rodriguez M and David, C: Role of MHC class II expressing CD4+ T cells in PLP91-110 induced EAE in HLADR3 transgenic mice. Eur J Immunol 2006; 36:3356-3370.
  311. Howe CL, Adelson JD, Rodriguez M.  Absence of perforin expression confers axonal protection despite demyelination. Neurobiol Dis 2007:354-359. PMC1857307.
  312. Warrington AE, Bieber AJ, Ciric B, Pease LR, Van Keulen V, and Rodriguez M. A Recombinant Human IgM Promotes Myelin Repair Following a Single Very Low Dose. J Neurosci Res 2007; 85:967-976.
  313. Rodriguez M. Effectors of demyelination and remyelination in the CNS: Implications for Multiple Sclerosis. Brain Path 2007; 17:219-229.
  314. Pavelko KD, Pease LR, David CS and Rodriguez M. Genetic deletion of a single immunodominant T cell response confers susceptibility to virus induced demyelination. Brain Path 2007; 17:184-196.
  315. Lassman H, Rodriguez M. SYMPOSIUM: New Disease Mechanisms in Multiple Sclerosis. Brain Path 2007; 17: 209.
  316. Howe CL, Ure D, Adelson JD, LaFrance-Corey R, Johnson A, Rodriguez M. CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination. J Neuroimmunol 2007; 188:13-21. PMC1986839.
  317. Mangalam A, Rodriguez M, David C. A new humanized HLA transgenic mouse model of multiple sclerosis expressing class II on mouse CD4 T cells. Ann N Y Acad Sci 2007; 1103:112-117.
  318. Rodriguez M,  Zoecklein L, Kerkvliet J, Pavelko K, Papke L, Howe CL, Pease LR, David C. Human HLA DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination. J Virology 2008; 82:3369-3380. PMC2268466
  319. Mangalam A, Basal E, Luckey D, Rodriguez M, and David C. HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma.  J Immunology 2008; 180:7747-7756. PMC2576747
  320. Rodriguez M, Zoecklein L, Papke L, Gamez J, Denic A, Macura SI, Howe CL. Tumor Necrosis Factor a is reparative via TNFR1 in the hippocampus and via TNFR2 in the striatum after virus-induced encephalitis. Brain Path 2009; 19:12-26. PMCID: PMC2613691
  321. Pirko I, Suidan GL, Rodriguez M, Johnson AJ. Acute hemorrhagic demyelination in a murine model of multiple sclerosis.  J Neuroinflammation 2008; 5:31. PMC2474604
  322. Scarisbrick I, Linbo R, Vandell A, Keegan M, Blaber M, Blaber SI, Sneve D, Lucchinetti C, Rodriguez M, Diamandis E. Tissue kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration. Biol. Chem.  2008; 389:739-745. PMCID: PMC2580060
  323. Rodriguez M, Warrington AE, Pease LR. Human Natural Autoantibodies in the Treatment of Neurologic Disease. Neurology 2009; 72: 1269-1276. PMC2677483.
  324. Mangalam A, Luckey D, Basal E, Jackson M, Smart M, Rodriguez M,  David C. HLA-DQ8 (DQB1*0302) Restricted Th17 cells Exacerbate Experimental Autoimmune Encephalomyelitis in HLA-DR3 Transgenic Mice.  J Immunol 2009; 182(8):5131-5139. PMC2665933.
  325. Deb C, LaFrance-Corey RG, Zoecklein L, Papke L, Rodriguez M, Howe CL. Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.  J Neuropathol Exp Neurol 2009; 68:1037-1048. PMC2767116
  326. Kelley BJ, Rodriguez M.  Seizures in Patients with Multiple Sclerosis: Epidemiology, Pathophysiology and Management. CNS Drugs 2009; 23:805-15. PMC2748351
  327. Wright BR, Warrington AE, Edberg DD, Rodriguez M. Cellular Mechanisms of CNS Repair by Natural Autoreactive Monoclonal Antibodies. Arch Neurol 2009; 66:1456-1459. PMC2796600
  328. Denic A, Bieber A, Warrington A, Mishra PK, Macura S, Rodriguez M.  Brainstem 1h-Nmr Spectroscopy: Marker of Demyelination and Repair in Spinal Cord. Ann Neurol, accepted May 2009; 66:559-564.  PMC2783718
  329. Kerkvliet J, Zoecklein L, Papke L, Denic A, Bieber AJ, Pease LR, David CS, Rodriguez M. Transgenic Expression of the 3D Polymerase Inhibits Theiler’s Virus Infection and Demyelination. J Virol 2009; 83:12279-12289. PMC2786735
  330. Schwartz-Albiez  R, Renato Monteiro R, Rodriguez  M, Binder C and Shoenfeld Y. Natural antibodies, IVIg and their role in autoimmunity, cancer and inflammation. Proceedings from the 6th International Immunoglobulin Symposium.  Clin Exp Immunol 2009; 158 (Suppl. 1): 43–50. PMC2801031.
  331. Maynard  JA, Lindquist NC, Sutherland JN, Lesuffleur A, Warrington AE, Rodriguez  M, and Oh S-H. Next generation SPR technology of membrane-bound proteins for ligand screening and biomarker discovery. J Biotech 2009; 4(11):1542-1558. PMC2790208. Figure chosen for Journal cover
  332. Chabas D,  Ness J, Yeh A, Kuntz N, De Kouchkovsky Y,  Strober  J,  Jin C, Gorman M, Belman A, Krupp L, Chitnis T, Rodriguez M, Weinstock-Guttman B, Waubant E, and the US Network of Pediatric MS Centers of Excellence. Younger children with pediatric MS have a distinct CSF inflammatory profile at disease onset. Neurology, accepted October 26, 2009; 74:399-405, 2010. PMC2816008.
  333. Bieber AJ, Suwansrinon K, Kerkvliet J, Zhang, W, Pease LR, Rodriguez M.  Allelic Variation in the Tyk2 and EGF Genes as Genetic Determinants of CNS Repair. Proc Natl Acad Sci USA accepted December 3, 2009; 107:792-797, 2010. PMC2818917
  334. Kuntz NL, Chabas D, Weinstock-Guttman B, Chitnis T, Yeh EA, Krupp L, Ness J, Rodriguez M, Waubant E, Network of US Pediatric Multiple Sclerosis Centers. Treatment of multiple sclerosis in children and adolescents. Expert Opin Pharmacother 2010 Mar; 11(4):505-20.
  335. Watzlawik J, Warrington AE, Rodriguez M. Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination. Expert Rev Neurother 2010 Mar; 10(3):441-457. PMC2842090
  336. Warrington AE, Rodriguez M. Method of Identifying Natural Antibodies for Remyelination. J Clin Immunol 2010; 30 (Suppl.1): S50-S55. PMC20387101
  337. Lesuffleur A, Lim KS, Lindquist NC, Im H, Warrington AE, Rodriguez M, Oh SH. Plasmonic nanohole arrays for label-free kinetic biosensing in a lipid membrane environment. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009; 1481-4.
  338. Kerkvliet J, Edukulla R, Rodriguez M. Novel roles of the picornaviral 3D polymerase in viral pathogenesis. Adv Virology, vol. 2010, Article ID 368068, 9 pages, 2010. doi:10.1155/2010/368068. PMC2897181.
  339. Watzlawik J, Holicky E, Edberg DD, Marks DL, Warrington AE, Wright BR, Pagano RE, Rodriguez M. Human Remyelination Promoting Antibody inhibits Apoptosis and Differentiation through Lyn Kinase in Oligodendrocytes. Glia, 2010 Jul 19; 58:1782-1793. [Epub ahead of print]. PMC2967300
  340. Deb C, LaFrance-Corey RG, Schmalstieg WF, Sauer BM, Wang H, German CL, Windebank AJ, Rodriguez M, Howe CL. CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis. PLoS One 2010; 5(8): e12478. PMC2930011.
  341.   Yeh EA, Waubant E, Krupp L, Ness J, Chitnis T, Kuntz N, Ramanathan M, Belman A, Chabas D, Gorman M, Rodriguez M, Rinker J, Weinstock-Gorman B. . Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis. Arch Neurol, 2011 Apr; 68(4):437-444.
  342. Tang J, Rodriguez M. Dalfampridine for the treatment of ambulatory impairment in multiple sclerosis. Future Neurology, 2010 5(5):637-643.
  343. Anderson G, Rodriguez M. Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin. Eur J Neurol 2010; 18:680-685.
  344. Kerkvliet J, Papke L, Rodriguez M. Broad Antiviral Effects of a Transgenic RNA-Dependent RNA-Polymerase. J Virology 2011; 85:621-625. PMC3014166.
  345. Denic A, Macura SI, Mishra P, Gamez JD, Rodriguez M, and Pirko I. MRI in Rodent Models of  Brain Disorder. Neurotherapeutics 2011; 8:3-18.
  346. Denic A, Zoecklein L, Kerkvliet J, Papke L, Edukulla R, Warrington A, Bieber A, Pease LR, David CS, Rodriguez M. Transgenic Expression of Viral Capsid Proteins Predisposes to Axonal Injury in a Murine Model of Multiple Sclerosis. Brain Path 2011; 21(5):501-15. PMC3139028.
  347. Magaña SM, Keegan BM, Weinshenker BG, Erickson BJ, Pittock SJ, Lennon VA, Rodriguez M, Thomsen K, Weigand S, Mandrekar J, Linbo L, Lucchinetti CF. Beneficial plasma exchange response in central nervous system inflammatory demyelination.. Arch Neurol, 2010; 68(7):870-878. PMC3134547
  348. Tang J, Rodriguez M. Recent advances in oral therapies for relapsing-remitting multiple sclerosis. Revista Española de Esclerosis Múltiple 2011; III:28-34.
  349. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh AE, Kuntz N, Ness J, Chabas D, Strober J, McDonald J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, Oksenberg JR, James JA for the U.S. Pediatric Network. Common viruses associated with lower pediatric multiple sclerosis risk. Neurol, accepted February 18, 2011, 76:1989-1995. PMC3109881
  350. Pavelko KD, Girtman MA, Mitsunaga Y, Mendez-Fernandez YV, Bell MP, Hansen MJ, Allen KS, Rodriguez M, Pease LR. Theiler's Murine Encephalomyelitis Virus as a Vaccine Candidate for Immunotherapy. PLoS One. 2011; 6(5):e20217. PMC3098865
  351. Wootla B, Lacroix-Desmazes S, Warrington AE, Bieber AJ, Kaveri SV, Rodriguez M. Autoantibodies with enzymatic properties in human autoimmune diseases. J Autoimmun. 2011; 37:144-150. PMC3173522
  352. Xu X, Warrington AE, Bieber AJ, Rodriguez M. Enhancing Central Nervous System            Repair: The Challenges. CNS Drugs. 2011; 25:555-573. PMC3140701
  353. Wootla B, Denic A, Keegan BM, Winters JL, Astapenko D, Warrington AE, Bieber AJ, Rodriguez M. Evidence for the role of B Cells and Immunoglobulins in the Pathogenesis of Multiple Sclerosis. Neurol Res Int 2011; 780712. PMC3179868
  354. Paz Soldan M, Pittock S, Weigand SD, Yawn B, Rodriguez M. Statin therapy and multiple sclerosis disability in a population-based cohort. Multiple Sclerosis Journal, 2012; 18:358-363. PMC3237737
  355. Xu X, Warrington AE, Wright BR, Bieber AJ, Van Keulen V, Pease LR, Rodriguez M. A Human IgM Signals Axon Outgrowth: Coupling Lipid Raft to Microtubule Dynamics.  J Neurochem 2011; 119: 100-112. PMC3171625
  356. Wittenberg NJ, Im H, Johnson TW, Xu X, Warrington AE, Rodriguez M, Oh S-H. Facile Assembly of Micro- and Nanoarrays for Sensing with Natural Cell Membranes. ACS Nano, 2011; 5:7555-7564. PMC3183111
  357. Denic A, Macura SI, Warrington AE, Pirko I, Grossardt BR, Pease LR, Rodriguez M. A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination. PLoS One. 2011; 6(10):e26001. Epub 2011 Oct 12. PMC3192139
  358. Hassan A, Ahlskog JE, Rodriguez M, and Matsumoto JY. Surgical therapy for multiple sclerosis tremor: A 12-year follow-up study. Eur J Neurol 2012; 19:764-768.
  359. Pavelko KD, Menendez-Fernandez Y, Bell MP, Hansen MJ, Johnson AJ, David CS, Rodriguez M, Pease LR. Nonequivalence of Classical MHC Class I Loci in Ability to Direct Effective Antiviral Immunity. PLoS Pathogens 2012; 8(2): e1002541. doi:10.1371/journal.ppat.1002541. PMC3285594
  360. Denic A, Pirko I, Wootla B, Bieber A, Macura S, Rodriguez M. Deletion of Beta2-microglobulin Ameliorates Spinal Cord Lesion Load and Promotes Recovery of Brainstem NAA Levels in a Murine Model of Multiple Sclerosis. Brain Path, 2012 Feb 15. doi:10.1111/j.1750-3639.2012.00576.x PMC3357463
  361. Scarisbrick IA, Yoon H, Panos M, Larson N, Blaber SI, Blaber M, Rodriguez M. Kallikrein 6 Regulates Early CNS Demyelination  in a Viral Model of Multiple Sclerosis. Brain Path, 2012 Feb 15. doi: 10.1111/j.1750-3639.2012.00577.x. PMC3360139
  362. Mangalam A, Luckey D, Giri S, Smart M, Pease L, Rodriguez M, David C. Two discreet subsets of CD8 T cells modulate PLP91-110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice. J Autoimmunity 2012; 38:344-53. PMC3581307
  363. Nastasijevic B, Wright B, Warrington A, Maher LJ, Rodriguez M. Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis. PLoS One 2012;7(6);e39595. PMC3384608.
  364. Tutuncu M, Tang J, Abou Zeid N, Kale N, Crusan DJ, Atkinson EJ, Siva A, Pittock SJ, Pirko I, Keegan BM, Lucchinetti CF, Noseworthy JH, Rodriguez M, Weinshenker BG, Kantarci OH. Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis. Mult Scler 2013; 19(2): 188-98  Jun 28. doi: 10.1177/1352458512451510.  PMC4029334
  365.  Wittenberg N, Im H, Xu X, Wootla B, Watzlawik J, Warrington A, Rodriguez M, Oh SH. High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance. Anal Chem. 2012; 84:6031-9. PMC3417152
  366. Xu X, Denic A, Warrington AE, Bieber AJ, Rodriguez M. Therapeutics to Promote CNS Repair - Natural Human IgMs Regulate Membrane-raft Dynamics and Improve Motility in a Mouse Model of Multiple Sclerosis. J Clin Immunol 2013; 33(Suppl 1): S50-6.   DOI 10.1007/s10875-012-9795-8;  PMC3548056
  367. Julian L, Serafin D, Charvet L, Ackerman J, Benedict RHB, Braaten E, Brown T, O’Donnell EH, Parrish J,  Preston T, Zaccariello M, Belman A, Chitnis T, Gorman M, Ness J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Yeh A, Krupp LB. Cognitive impairment occurs early in pediatric multiple sclerosis: Results from a US network. J Child Neurology 2012; 28:102-107. PMC3652651.
  368. Watzlawik JO, Warrington AE, Marks DL, Pagano R, Rodriguez M.  PDGF is required for Remyelination Promoting IgM Stimulation of Oligodendrocyte Progenitor Cell Proliferation. PLoS One, 2013; 8(2):e55149. PMC3562326
  369. Wootla B, Watzlawik JO, Denic A, Rodriguez M. The road to remyelination in demyelinating diseases: current status and prospects for clinical treatment. Expert Rev Clin Immunol 2013 Jun; 9(6):535-49. PMC Journal in Process.
  370. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh A, Kuntz  N, Ness J, Belman A, Milazzo M,Weinstock-Guttman B, Gorman M, Rodriguez M, James  JA. Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric MS. Mult Scler 2013; 19:891-895. PMC3665694
  371. Xu X, Wittenberg NJ, Jordan LR, Kuman S, Warrington AE, Oh S-H, Rodriguez M. A Patterned Recombinant Human IgM Guides Neurite Outgrowth of CNS Neurons. Scientific Reports 2013; 3:2267. PMC3721078.
  372. Mangalam AK, Poisson LM, Nemutlu E, Datta I, Denic A, Dzeja P, Rodriguez M, Rattan R, Giri S. Profile of circulatory metabolites in an animal model of multiple sclerosis using global metabolomics. J Clin Cell Immunol 2013; 4:150.  PMC3837296.
  373. Wittenberg NJ, Johnson TW, Jordan LR, Xu X, Warrington AE, Rodriguez M, Oh S-H. Formation of biomembrane microarrays with a squeegee-based assembly method.  J Vis Exp. 2014; (87). PMC4032179.
  374. Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttmann B, Yeh E, Rodriguez  M, Ness J, Gorman M, Healy BC, Chabas D, Strober JB, Waubant E, Krupp L, Pelletier D, Erickson B, Bergsland N, Zivadinov R.  Quantitative MRI analysis in children with multiple sclerosis: A Multicenter Feasibility pilot study. BMC Neurology, BMC Neurol. 2013 Nov 13; 13(1):173. PMC3832402.
  375. Denic A, Wootla B, Zoecklein L, Rodriguez M. Deletion of virus-specific T-cells enhances remyelination in a model of multiple sclerosis. J Neurol Transl Neurosci 2014; 2(1):1032.  PMC4222056.
  376. Charvet LE, O'Donnell EH, Belman AL, Chitnis T, Ness JM, Parrish J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Krupp LB; US Network of Pediatric MS Centers. Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: report from the US Pediatric Multiple Sclerosis Network.  Multiple Sclerosis, 2014; 20(11):1502-10. PMC4192109.
  377. Panos M, Christophi G, Rodriguez M, Scarisbrick I. Differential Expression of Multiple Kallikreins in a Viral Model of Multiple Sclerosis Points to Unique Roles in the Innate and Adaptive Immune Response. Biol Chem, 2014; 395:1063-1074.
  378. Dacy LC, Rodriguez M. Interrupted Concerto: Jacqueline du Pré and MS. Hektoen International 2014 Volume 6(4)  http://www.hektoeninternational.org/index.php?option=com_content&view=article&id=1255
  379. Graves J, Grandhe S, Weinfurtner K, Krupp L, Belman A, Chitnis T, Ness J, Weinstock-Guttmann B, Gorman MP, Patterson MC, Rodriguez M, Lotze T, Aaen G, Mowry EM, Rose J, Simmons T, Casper TC, James J, Waubant E. Protective environmental factors for neuromyelitis optica. Neurology 2014;83:1923-1929.
  380. Casper TC, Rose JW, Roalstad S, Waubant E, Aaen G, Belman A, Chitnis T, Gorman M, Krupp L, Lotze TE, Ness J, Patterson M, Rodriguez M, Weinstock-Guttman B,Browning B, Graves J, Tillema J-M, Benson L, Harris Y. The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps. Journal of Child Neurology 2014; In Press.
  381. Mangalam A, Luo N, Luckey D, Papke L, Hubbard A, Wussow A, Smart M, Giri S, Rodriguez M, David C. Absence of IFNγ Increases Brain Pathology in EAE-susceptible DRB1*0301.DQ8 HLA Transgenic Mice Through Secretion of Pro-inflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the CNS. J Immunology 2014; 193(10):4859-70. PMC4233133.
  382. Rodriguez M, Warrington, AE, Wootla B. Antibody-based Treatments. International Innovation, 2014;153:132-134.
  383. Anderson G, Rodriguez M. Multiple Sclerosis: The role of melatonin and N-acetylserotonin. Multiple Sclerosis and Related Disorders, J Med Virol In Press 2015.
  384. Anderson G., Maes M., Markus R.P., Rodriguez M.; Ebola Virus: Melatonis as a Readily Available Treatement Option. J. Med. Virol. Accepted.
  385. Xu X., Ng SM., Hassouna E., Warrington A., Oh SH., Rodriguez M: Human-derived natural antibodies: biomarkers and potential therapeutics Future Neurology  Accepted NIHMSID #654005
  386. Paz Soldan MM, Novotna M, Abou Zeid N, Kale N, Tutuncu M, Crusan DJ, Atkinson EJ, Siva A, Keegan BM, Pirko I, Pittock SJ, Lucchinetti CF, Weinshenker BG, Rodriguez M, Kantarci OH. Relapses and disability accumulation in progressive multiple sclerosis. Neurology, 2015, 84(1):81-88.
  387. Perschbacher K, Smestad JA, Peters JP, Standiford MM, Denic A, Wootla B, Warrington AE, Rodriguez M, Maher LJ 3rd. Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice. Nucleic Acid Ther 2015, 25(1):11-29.

Publications in Submission:

  1. Waldman A, Gorman MP, Rensel M, Austin T, Hertz D, Rodriguez M, Kuntz N. Pediatric CNS Demyelinating Disorders:  Survey of US Practice Patterns. Neurology, submitted.
  2. Yeh EA, Ness J, Hertz D, Krupp L, Weinstock-Guttman, Belman A, Waubant E, Gorman M, Chitnis T, Rodriguez M, Patterson MC, Strober J, Kuntz NL, Chabas D. Breakthrough disease in pediatric MS patients. Neurology, submitted.
  3. Chabas D, Chitnis T, Krupp L, Kuntz N, Ness J, Rodriguez M, Rubin J, Strober J, Waubant E. Pediatric Multiple Sclerosis. Neurologic Clinics Review, submitted
  4. Chitnis T, Musallam A, Zaitsev A, Healy BC, Weinstock-Guttmann B, Yeh E, Ness J, Rodriguez M, Kuntz N, Gorman M, Caruso P, Strober JB, Chabas D, Waubant E, Krupp L, Pelletier D, Bergsland N, Guttmann CR, Zivadinov R, Erickson B. Qualitative MRI features of pediatric multiple sclerosis. J Child Neurology, submitted.
  5. Pirko I, Gamez J, Rodriguez M, Babovic M, Browning E, Johnson A, Macura S. The Clinico-Radiological Paradox in Murine Models of Multiple Sclerosis. J Neuroimaging, submitted.
  6. Wootla B, Denic A, Zoecklein L, Papke L, David C, Rodriguez M. Human MHC Class I Alleles Determine CNS Injury versus Repair. J Autoimmunity, submitted.
  7. Chitnis T, Ness J, Krupp L, Waubant e, Hunt T, Rodriguez M, Lotze T, Gorman M, Belman A, Weinstock-Guttmann, Aaen G, Patterson M, Rose J, Casper C, for the U.S. Network of Pediatric MS Centers of Excellence. Neurology, submitted.
  8. Wootla B, Denic A,Watzlawik J.O.,Warrington A.E. and Rodriguez M. Serum-Derived Human Monoclonal IgM12 Improves Neurologic Function and increases Brainstem NAA Concentrations and Density of Spinal Cord Axons.  BMC Neuroscience, submitted
  9. Xu X,  Denic A, Jordan LR, Wittenberg NJ, Warrington AE, Wootla B, Papke LM, Zoecklein LJ, Yoo D, Shaver J, Oh SH, Pease LR, Rodriguez M; A Human Natural IgM that Binds to Gangliosides Improves Survival in Murine Models of Amyotrophic Lateral Sclerosis,Neurobiology of Disease, submitted
  10. Painter M, Zoecklein LJ, Rinkoski RA, Morrison JH, Watzlawik JO, Papke LM, Warrington   AE, Bieber  AJ, Matchett WE, Turkowski KL, Poeschla EM,  Rodriguez M. RdRP-mediated Broad Spectrum Antiviral Protection Via Stable Activation of Innate Immunity, submitted

Books

  1. Rodriguez M.      Editor, Advances in Multiple Sclerosis. (Current Topics in Microbiology and Immunology, vol. 318); Heidelberg: Springer-Verlag, 2008.
  2. Rodriguez M, Kantarci OH and Pirko I. Multiple Sclerosis. (Contemporary Neurology Series); New York: Oxford University Press, 2013.         

Book Chapters

  1. Rodriguez M:  "Multiple Sclerosis", edited by W. Ian McDonald and Donald Silbers, Mayo Clinic Proceedings 1986; 61:839-840.
  2. Rodriguez M:  "Interferon Treatment of Neurologic Disorders", edited by Richard Alan Smith, Mayo Clinic Proceedings.
  3. Rodriguez M:  "Ultrastructural Study of the Human Diseased Peripheral Nerve", edited by Claude Vital and Jean-Michel Vallat.  J. of Neuropath. Exp. Neurol.
  4. Rodriguez M:  “Molecular Biology of Multiple Sclerosis”, edited by W. C. Russell, J. Neuropathology and Applied Neurology.
  5. Rodriguez M:  "Multiple Sclerosis Immunology, Pathology, and Pathophysiology", by Robert M. Herndon, M.D., Annals of Neurology.
  6. Rodriguez M, David CS, Pease LR: The Contribution of MHC Gene Products to Demyelination by Theiler's virus.  IN: H-2 Antigens.  Edited by Chella S. David, Plenum Publishing Corporation, New York: NY, 1987; 46:747-756.
  7. Rodriguez M: The Cellular Immune Response and Pathogenesis of Theiler's Virus-induced Demyelination.  IN: Viruses and the Cellular Immune Response.  D. Brian Thomas, Editor.  Marcel Dekker Inc., New York, NY, 1993; pp. 473-489.
  8. Rodriguez M, Prayoonwiwat N, Pease LR: Polymerase Chain Reaction Detection of Human T-cell Lymphotrophic Virus Type I (HTLV-I).  IN: Diagnostic Molecular Microbiology. D.H. Persing, Editor.  ASM Press, Herndon, VA, , 1993 pp. 316-321
  9. Weinshenker BG, Rodriguez M: Epidemiology of Multiple Sclerosis.  IN: Handbook of Neuroepidemiology.  Gorelick PB and Alter M, editors.  Marcel Dekker, Inc: New York: NY, 1994; pp. 533-567.
  10. Hunter SF, Asakura K, Miller DJ, Rodriguez M: The Repair of Central Nervous System Myelin: Cell Biology and Pharmacologic Action of Remyelination-Promoting Autoantibodies. Fourth Altschul Symposium.  Plenum Press.  IN: Cell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches.  R. M. Devon, R. Doucette, B. H. J. Juurlink, A. J. Nazarali, D. J. Schreyer, and V. M. K. Verge, Editors(Chapter): 1997;pp.253-264. 
  11. Njenga KM., Rodriguez M: Viral Immune Interactions.  In: Clinical Neuroimmunology, J.P. Antel, G. Birnbaum, H.P. Hartung, eds., Blackwell Science Inc., Boston, 1998, pp. 72-91.
  12. Weinshenker BG, Rodriguez M: Treatment of Catastrophic Multiple Sclerosis.  Blue Books of Practical Neurology – Multiple Sclerosis 2.  John Noseworthy and W. Ian McDonald, eds. New York: Oxford University Press (USA), 2003; 207-216.
  13. Bieber AJ, Rodriguez M: Experimental Models of Virus-Induced Demyelination.   IN Myelin: Biology and Disorders.  Edited by J Griffin, H Lassmann, K-A Nave, B Trapp, R Lazzarini, and R Miller. New York: Elsevier Academic Press: 2003. 44:1-27.
  14. Rodriguez M: Diagnosis Case 19; Neuromyelitis Optica (Devic’s disease).  IN Fifty Neurologic Cases from Mayo Clinic. Edited by J. Noseworthy. New York: Oxford University Press (USA), 2004; 73-77.
  15. Asakura K, Rodriguez M: Strategies to Promote Central Nervous System Remyelination In Vivo.  IN: Jerserich, G., Althaus, H. H., Richter-Landsberg, C., and Heumann, R. (eds.).  Molecular Signaling and Regulation in Glial Cells: A Key to Remyelination and Functional Repair.  Springer-Verlag, Berlin,: 1997;pp. 297-311
  16. Johnson AJ, Rodriguez M, Pease LR: Class I Major Histocompatibility Molecules Play a Critical Role in Resistance to Theiler's Virus Infection. IN: New Concepts in the Immunopathogenesis of CNS Infections.  Peterson and Remington, editors.  Published by Blackwell Science, Inc., Malden, Massachusetts.  2000; pp. 296-316.
  17. Howe CL, Rodriguez, M. Remyelination as Neuroprotection IN: Multiple Sclerosis as a Neuronar Disase. Stephen Watman (Editor).  New York: Elsevier Academic Press, 2005; p. 389-419
  18. Ure D, Rodriguez M.  Histopathology in the Theiler’s Virus Model of Demyelination.  In Experimental Models of Multiple Sclerosis Ehud Lavi, (Editor): 2005; p. 580-591 Springer Science+Business Media, Inc.
  19. Warrington AE, Rodriguez M. Regeneration strategies for multiple sclerosis. In: Handbook of multiple sclerosis. 4th Edition, Vol. 80.  SD Cook, editor. New York: Taylor & Francis; 2006. (Neurological Disease and Therapy.) p. 453-75.
  20. Pittock SJ, Rodriguez M. Benign MS: A distinct clinical entity with therapeutic implications. IN: Advances in Multiple Sclerosis. Moses Rodriguez, editor. Heidelberg: Springer-Verlag, 2008. (Current Topics in Microbioloby and Immunology, vol. 318); p.1-18.
  21. Warrington AE, Rodriguez M. Remyelination-promoting human IgMs: Developing a therapeutic reagent for demyelinating disease. IN: Advances in Multiple Sclerosis. Moses Rodriguez, editor. Heidelberg: Springer-Verlag, 2008. (Current Topics in Microbioloby and Immunology, vol. 318); p.213-240.
  22. Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E. Pediatric Multiple Sclerosis. IN Multiple Sclerosis. EL Waubant and RW Evans, editors. Philadelphia: Saunders, 2011. (Neurologic Clinics, vol. 29); p. 481-505.
  23. Yeh AE, Rodriguez M. Disease modifying therapy and response to treatment in Pediatric MS. IN: Chabas D; Waubant EL editor. Demyelinating disorders of the central nervous system in childhood. Cambridge; New York: Cambridge University Press; 2011. (Cambridge Medicine.). p. 96-100.
  24. Warrington AE, Van Keulen V, Pease LR, Rodriguez M. Natural Antibodies as Therapeutics for Neurologic Disease: Can Human Recombinant Monoclonal Immunoglobulins Replace the Limited Resource IVIg? IN: Naturally Occurring Antibodies. H. Lutz, editor. Advances in Experimental Medicine and Biology 2012; 750(1): 44-55. Landes Bioscience and Springer Science+Business Media. 


Moses Rodriguez, MD

Professor of Neurology

 

  • : (507) 284-3734
  • DEPARTMENTMayo Medical School
  • COUNTRYUSA