Peer-Reviewed Publications

  1. Zhang, L., Q. Zou and B-S. Cheng. Tissue culture of Polygonum multiflorum. Plant Physiology Communications (Chinese) 1:28, 1987a.
  2. Zhang, L., Q. Zou and B-S. Cheng. Plantlet regeneration of Saxifraga stoloniferta. Plant Physiology Communications (Chinese) 6:48, 1987b.
  3. Zhang, L., P.M. Mohan and R. Padmanaban. Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-N55. J. Virol. 66:7549-7554, 1992.
  4. Zhang, L., and R. Padmanaban. Role of protein conformation in dengue virus type 2 polyprotein processing. Gene 129:197-205, 1993.
  5. Kapoor, M., L. Zhang, M. Ramachandra, J. Kusukawa, K. Ebner and R. Padmanabhan. Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J. Biol. Chem. 270:19100-19106, 1995.
  6. Kapoor, M., L. Zhang, P.M. Mohan and R. Padmanabhan. Synthesis and characterization of an infectious RNA encoding dengue virus type 2 genome (New Guinea C strain). Gene 162:175-180, 1995.
  7. Ide, U., L. Zhang, M. Chen, G. Inchauspe, C. Bahl, Y. Sasaguri and R. Padmanabhan. Characterization of the Nuclear Localization Signal and Subcellular Distribution of Hepatitis C Virus Nonstructural Protein NS5A. Gene 182:203-211, 1996.
  8. Zhang, L. and J.S. Pagano. IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol. Cell. Biol. 17:5748-5757, 1997.
  9. Zhang, L. and J.S. Pagano. . Interferon regulatory factor 2 represses the Epstein-Barr Virus BamH I Q latency promoter in type III latency. Mol. Cell. Biol. 19:3216-3223, 1999.
  10. Zhang, L. Gradient temperature hybridization for RNase protection assays. Molecular Biotechnology14:73-75. 2000a.
  11. Zhang, L. and J.S. Pagano. Interferon regulatory factor 7 is induced by Epstein-Barr virus latent membrane protein 1. J. Virol. 74:5748-57. 2000b.
  12. Zhang, L. and J.S. Pagano. Interferon regulatory factor 7 mediates the activation of the transporter associated with antigen processing 2 (Tap-2) by Epstein-Barr virus latent membrane protein 1. J. Virol. 75:341-350. 2000c.
  13. Zhang, L. and J.S. Pagano. Interferon Regulatory Factor 7: a Key Cellular Mediator of LMP-1 in EBV Latency and Transformation. Seminars in Cancer Biology11:445-53. 2001a
  14. Zhang, L., L. Wu, K. Hong, and J.S. Pagano. Intracellular signaling molecules activated by Epstein Barr virus for induction of interferon regulatory factor 7. J. Virol. 75:12393-401. 2001b.
  15. Zhang, L. and J.S. Pagano.  Structure and Function of Interferon Regulatory Factor 7.  J Interferon Cytokine Res. 22: 95-101. 2002a. 
  16. Zhang, L. and J.S. Pagano.  Interferon Regulatory Factor 7 and Virus-Cell Interactions.  Recent Research Developments in Molecular and Cellular Biology.  3:235-241. 2002b.
  17. Zhang, L. ,K. Hong, J. Zhang, and J. S. Pagano.  Multiple signal transducers and activators of transcription (STATs) are induced by EBV LMP-1. Virology.  323:141-152. 2004a.
  18. Zhang, L., J. Zhang, Q. Lambert, C. J. Der, L. Del Valle, J. Miklossy, K. Khalili, Y. Zhou,and J. S. Pagano. Interferon regulatory factor 7 is associated with EBV-transformed CNS lymphoma and has oncogenic properties. J. Virol. 12987-12995. 2004b.
  19. Zhang, J., S. Das, C. Kotalik,, A. Pattnaik, and L.  Zhang.  The latent membrane protein 1 of Epstein-Barr virus establishes an antiviral state via induction of interferon-stimulated genes.  J Biol Chem. 279:46335-46342. 2004c.
  20. Wang J, J.  Zhang, L. Zhang, Harrington W Jr, West JT, Wood C. Modulation of Human Herpesvirus 8/Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator Transactivation by Interferon Regulatory Factor 7. J Virol. 79:2420-31. 2005.
  21. Zhang, J., J. Wang, C. Wood, and L. Zhang.  KSHV/HHV-8 replication and transcription activator (RTA) regulates both viral and cellular genes via interferon-stimulated response elements. J Virol. 79: 5640-52. 2005.
  22. Xu D, K. Brumm, L. Zhang. The latent membrane protein 1 of Epstein-Barr virus primes EBV latency cells for type I interferon production. J Biol Chem. 281: 9163-9169. 2006.
  23. Lu, G.,  L. Jiang, R. Kotalik,  T.W. Rowley, L. Zhang, X. Chen, and E. Moriyama. GenomeBlast: a Web Tool for Small Genome Comparison. BMC Bioinformatics. 2006:7 Suppl 4:S18.
  24. Xu, D., J. Zhang, T. Coleman, A. Fagot, C.  Kotalik, L. Zhao, P. Trevidi, C. Jones, and L. Zhang.  Epstein-Barr Virus Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication In Primary Effusion Lymphomas. J. Virol.  81(11):6068-78.2007.
  25. Papugani, A., T. Coleman, and L. Zhang.  The interaction between KSHV/HHV-8 replication and transcription activator (RTA) and cellular RBP-J and their subsequent DNA binding are not sufficient for disruption of KSHV lytic replication. Virus Res.  Virus Research. 131(1):1-7. 2008.
  26. Jiang, Y., D. Xu, Y. Zhao, and L. Zhang.  Mutual Inhibition between Kaposi’s Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Lytic Replication Initiators in Dually-Infected Primary Effusion Lymphoma. PLoS One. 3:e1569. 2008.
  27. Angeletti PC, Zhang L, Wood C. The Viral Etiology of AIDS-Associated Malignancies. Adv Pharmacol. 56:509-57. 2008.
  28. Xu, D., L. Zhao, L. Del Valle, J. Miklossy, and L. Zhang.  Interferon regulatory factors 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. J Virol. 82:6251-8. 2008.
  29. Yunlong Huang, Angelique Walstrom, Luwen Zhang, Yong Zhao, Min Cui, Ling Ye, Jialin C. Zheng. Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLoS ONE 4(4): e5397. 2009.
  30. Zhao, Y., D. Xu, , Y. Jiang, and L. Zhang. Dual functions of Interferon regulatory factors 7C in Epstein-Barr virus-mediated transformation of human B lymphocytes. PLoS One. 5(3) e9459. 2010.
  31. Xu, D., and L. Zhang.  A system for production of human personalized type I interferons. Biotechnol. J. 5:578–581. 2010. 
  32. Ahmad H, Gubbels R, Ehlers E, Meyer F, Waterbury T, Lin R, Zhang L. Kaposi's sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta interferon (TRIF). J Biol Chem. 286(10):7865-72. 2011.
  33. Xu D, Meyer F, Ehlers E, Blasnitz L, Zhang L. Interferon Regulatory Factor 4 (IRF-4) Targets IRF-5 to Regulate Epstein-Barr Virus Transformation. J Biol Chem. 286:18261-7. 2011.
  34. Valente RM, Ehlers E, Xu D, Ahmad H, Steadman A, Blasnitz L, Zhou Y, Meng B, Zhang L. Toll-Like Receptor 7 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1. PLoS ONE 7(8): e43317. doi:10.1371/journal.pone.0043317. 2012
  35. Florencia Meyer, Erica Ehlers, Andrew Steadman, Thomas Waterbury, Mingxia Cao, and Luwen Zhang, TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator. J Biol Chem. 2013 Jul 12;288(28):20435-42. Epub 2013 May 30.
  36. Xu, D, Erica Ehlers, Andrew Steadman, and Luwen Zhang, CD20 antibody enhances cells for type I interferon productions. PLoS ONE 8(6): e67900. doi:10.1371/journal.pone.0067900. 2013.
  37. Mingxia Cao, Qianli Wang, Amy Lingel and Luwen Zhang. Nuclear factor κB represses the expression of latent membrane protein 1 in Epstein-Barr virus transformed cells. World J Virology. 12: 22-29. 2014. Published online 2014 November 12. doi: 10.5501/wjv.v3.i4.22.
  38. Xu, D, Zhang, YY., Zhao, L., Cao, M., Lingel, A., and Zhang, L.. Interferon regulatory factor 7 is involved in the growth of Epstein–Barr virus-transformed human B lymphocytes. Virus Research 195:112–118. 2015


Luwen Zhang, PhD

Professor of Biological Sciences


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  • DEPARTMENT University of Nebraska – Lincoln