Publications

  1. Phillips MD, Kuznetsov SA, Cherman N, Park K, Chen KG, McClendon BN, Hamilton RS, McKay RD, Chenoweth JG, Mallon BS, Robey PG*. Directed Differentiation of Human Induced Pluripotent Stem Cells Toward Bone and Cartilage: In Vitro Versus In Vivo Assays. Stem Cells Transl Med. 2014 May 22. pii: sctm.2013-0154.
  2. Chen KG*, Hamilton RS, Robey PG, and Mallon BS. Alternative cultures for human pluripotent stem cell production, maintenance, and genetic analysis The Journal of Visualized Experiments (JoVE), in press, 2014.
  3. Mallon BS§*, Chenoweth JG§, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, and McKay RD. StemCellDB: The Human Pluripotent Stem Cell Database at the National Institutes of Health. Stem Cell Research, Available online 26 September 2012
  4. Padmanaban R§, Chen KG§, Gillet JP, Handley M, Mallon BS, Hamilton RS, Park K, Varma S, Mehaffey MG, Robey PG, McKay RD, and Gottesman MM*. Expression and function of ATP-binding cassette transporters in human embryonic stem cells. Stem Cells 2012
  5. Chen KG§*, Mallon BS§, Hamilton RS, Kozhich O, Park K, Hoeppner DJ, and McKay RD*. Non-colony type monolayer culture of human embryonic stem cells. Stem Cell Research 9, 237-248, 2012
  6. Chen KG, Leapman RD Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, and Gottesman MM*. Influence of melanosome dynamics on melanoma drug sensitivity. The Journal of the National Cancer Institute 101, 1259-1271, 2009.
    @JNCI news brief: Melanosome dynamics and sensitivity of melanoma cells to chemotherapy. Public release date: August 24, 2009.http://www.eurekalert.org/pub_releases/2009-08/jotn-jnb082009.php
  7. Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW*, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature Biotechnology 25, 803-816, 2007.
  8. Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi Y, Miller Jenkins LM, Nagashima K, Appella E, and Hearing VJ*. Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. Journal of Biological Chemistry 282, 11266-11280, 2007.
  9. Rouzaud F, Costin G-E, Yamaguchi Y, Valencia JC, Berens WF, Chen KG, Hoashi T, Bohm M, Abdel-Malek ZA, and Hearing VJ*. Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1- receptor isoforms. The FASEB Journal 20, 1927-1929, 2006.
  10. Chen KG, Valencia JC, Lai B, Zhang GF, Paterson J, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman R, Hearing VJ, and Gottesman MM*. Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proceedings of the National Academy of Sciences of the U.S.A. 103, 9903-9907, 2006.
    @Melanosomes Contribute to Multidrug Resistance in Melanoma. NCI Cancer Bulletin, Vol. 3, No. 25; June 20, 2006. http://www.cancer.gov/ncicancerbulletin
    @Poor Response of Malignant Melanomas to Chemotherapy is linked to Melanosomes. CCR Frontiers, National Cancer Institute, Bethesda, MD, April 2007.
    @Faculty of 1000 Biology (evaluations for Chen KG et al, Proc Natl Acad Sci USA 2006 Jun 27 103 (26): 9903-7, http://www.f1000biology.com/article/id/1033013/evaluation. [F1000 Factor 6.0, ‘MUST READ’], 2006.
    @Mechanism of Resistance Identified. DermatologyTimes, August 1, 2006.
    http://www.dermatologytimes.com/dermatologytimes/
    @Melanoma Drug Resistance. The Journal of American Medical Association (JAMA), July 26, 2006-Vol. 296, No. 4
  11. Valencia JC, Watabe H, Chi A, Rouzaud F, Chen KG, Vieira WD, Takahashi K, Yamaguchi Y, Berens W, Nagashima K, Shabanowitz J, Hunt DF, Appella E, Hearing VJ*. Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes. Journal of Cell Science 119: 1080-1091, 2006.
  12. Wang YC, Juric D, Francisco B, Yu RX, Duran GE, Chen GK, Chen X, and Sikic BI*. Regional activation of chromosome 7q with or without gene amplification in taxane-selected human ovarian carcinoma cell lines. Genes, Chromosomes & Cancer 45:365-374, 2006.
  13. Chen KG*, Wang Y, Schaner ME, Francisco B, Duran GE, Juric D, Huff LM, Padilla-Nash H, Ried T, Fojo T, and Sikic BI. Genetic and molecular modeling of the origins of multidrug resistant cells in a human sarcoma cell line. Cancer Research, 65: 9388-9307, 2005.
  14. Chen KG, Szakacs G, Annereau J-P, Rouzaud F, Liang, XJ, Valencia JC, Nagineni, CN, Hooks JJ, Hearing VJ, and Gottesman MM*. Principal expression of two mRNA isoforms (ABCB5and ABCB5) of the ATP-binding cassette transporter ABCB5, in melanoma cells and melanocytes. Pigment Cell Research 18:102-112, 2005.
    @Wanted: Specific Cancer ‘Mug shots’, p16, Cell Biology (2004), The American Society for Cell Biology (ASCB), December 2004; ASCB Ten AM Press Briefing, December 6, 2004. http://www.newswise.com/articles/view/508665
  15. Chen KG and Gottesman MM*. Useful tool to generate unidirectional deletion vectors by utilizing the star activity of BamHI in an NcoI-BamHI-XhoI cassette. BioTechniques 38:198-204, 2005.
  16. Liang XJ, Shen DW, Chen KG, Garfield SH, Wincovich SM, and Gottesman MM*. Trafficking and localization of platinum complexes in cisplatin‐resistant cell lines monitored by fluorescence‐labeled platinum. Journal of Cell Physiology 202: 635-41, 2005.
  17. Dumontet C, Jaffrezou JP, Tsuchiya E, Duran GE, Chen G, Derry WB, Wilson L, Jordan MA, Sikic BI*. Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization. Bull Cancer 91(5): E81-112, 2004.
  18. Chen GK, Sale S, Tan T, Ermoian RP, and Sikic BI*. CCAAT/enhancer protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells. Molecular Pharmacology 65: 906-916, 2004.
    @Top ten articles viewed by Molecular Pharmacology Readers during the month of April 2004.
  19. Chen GK§, Lacayo NJ§, Duran GE, Wang Y, Bangs CD, Rea S, Kovacs M, Cherry A, Brown JM, and Sikic BI*. Preferential expression of a mutant allele of the amplified MDR1 gene in drug-resistant variants of a human sarcoma. Gene Chromosome & Cancer 34: 372-383, 2002.
  20. Chen GK, Duran GE, Mangili A, Beketic-Oreskovic L, and Sikic BI*. MDR1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells. British Journal of Cancer 83: 892-898, 2000.
  21. Chen GK, Lacayo NJ, Duran GE, Cohen D, Sikic BI*. Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted Phe(335). Molecular Pharmacology 57: 769-777, 2000.
  22. Chen G, Duran GE, Steger KA, Lacayo NJ, Jaffrezou J-P, Dumontet C, and Sikic BI*. Multidrug resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins. Journal of Biological Chemistry 272, 5974-5892, 1997.
  23. Jaffrezou J-P, Dumontet C, Derry WB, Duran G, Chen G, Tsuchiya E, Wilson L, Jordan MA, and Sikic BI*. Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833. Oncology Research 7: 517-527, 1995.
  24. Beketic-Oreskovic L, Duran GE, Chen G, Dumontet C, and Sikic BI*. Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833. Journal of the National Cancer Institute 87: 1593-1602, 1995.
  25. Jaffrezou JP*, Chen G, Duran GE, Muller C, Bordier C, Laurent G, Sikic BI, and Levade T. Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance. Biochimica et Biophysica Acta 1266: 1-8, 1995.
  26. Chen G*, Hu YS, Sun BZ, Zhang JQ, and Su, BX. Static imaging using SPECT in differentiating between benign and malignant lesions of the jaws. Journal of Xian Medical University (in Chinese) 16, 302-305, 1995
  27. Dong YJ, Chen G, Duran GE, Kouyama K, Chao AC, Sikic BI, Gollapudi SV, Gupta S, and Gardner P*. Volume-activated chloride current is not related to P-glycoprotein overexpression. Cancer Research 54: 5029-5032, 1994.
  28. Chen G, Jaffrezou J-P, Fleming WH, Duran GE, and Sikic BI*. Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection. Cancer Research 54: 4980-4988, 1994.
  29. Jaffrézou J-P, Chen G, Duran GE, Kuhl J-S, and Sikic BI*. Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis. Journal of the National Cancer Institute 86: 1152-1158, 1994.
  30. Chen G*, Hu Y, and Sun B. Analysis of normal SPECT images of cranio-maxillofacial bones. West China Journal of Stomatology 12 (3): 192-194, 1994
  31. Chen G*, Hu Y, Wang S, and Sun B. Cranio-maxillofacial 99mTc-MDP imaging of a giant schwanoma (Case report). Journal of Xian Medical University (in Chinese) 14: 290, 1993
  32. Chen G*, Hu Y, Zhang J, and Sun B. A comparative study among radionuclide bone scan, X-ray, and ultrasonography in evaluating the diseases of the jaws. Journal of Practical Stomatology (in Chinese) 8: 144-146, 1992
  33. Chen G*, Liu GH, Chen SG, Chen SY, and Zhu HG. The surgical treatment of a giant mixed tumor of parotid gland in a 90-year-old woman (Case Report). Journal of Shantou University Medical College (in Chinese) (1.2): 148-149, 1991
  34. Chen G*, Hu Y, Sun B, Zhang J, and Shu B. Radionuclide bone scan using SPECT in detecting oro-maxillofacial tumors infiltrating to the jaws. Chinese Journal of Stomatology (in Chinese) 26: 285-287, 1991.

Perspectives And Reviews

  1. Padmanaban R, Chen KG, and Gottesman MM*. Lost in translation: Regulation of ATP-binding cassette transporters in human embryonic stem cells. Journal of Stem Cell Research and Therapy 4 (180); 2, 2014.
  2. Chen KG*, Mallon BS, Johnson KR, Hamilton RS, McKay RD, and Robey PG. Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation. Stem Cell Research, online, 2014.
    @Top 1 most downloaded article published January to August 2014.
  3. Chen KG*, Mallon BS, McKay RD, and Robey PG. Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell 14; 13-26, 2014.
    @Top 6 most read articles for the 30 days preceding January 23, 2014.
  4. Chen KG and Sikic BI*. Molecular Pathways: Regulation and therapeutic implications of multidrug resistance. (Invited Review). Clinical Cancer Research (Published OnlineFirst February 16, 2012).
  5. Chen KG, Valencia JC, Gillet JP, and Hearing VJ, and Gottesman MM*. Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma (Invited Review). Pigment Cell & Melanoma Research (Accepted Article Online: August 29), 22; 740–749, 2009.
  6. Mallon BS*, Park KY, Chen KG, Hamilton RS and McKay RD. Toward xeno-free culture of human embryonic stem cells. International Journal of Biochemistry and Cell Biology 38: 1063-1075, 2006.
  7. Sikic BI*, Fisher GA, Lum BL, Halsey J, Beketic-Oreskovic L, Chen G. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer Chemotherapy & Pharmacology 40 Suppl: S13-9, 1997.
  8. Chen G*, Zhang ZY, and Qiu WL. Application of monoclonal antibodies against malignant melanoma. International Journal of Stomatology (Chinese) 19: 129-133, 1993.
  9. Chen G*, Hu Y, and Sun B. Radionuclide imaging for head and neck tumors. International Journal of Stomatology (Chinese) 18: 142-145, 1991.

Editorials And Commentaries

    44. Szakacs G, Chen GK, and Gottesman MM*. The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance. Cancer Biology & Therapy 3: 382-384, 2004.

Book Or Book Chapters

    45. Chen KG and Gottesman MM*. How melanoma cells evade chemotherapy: role of transporter-dependent and independent mechanisms. In: Melanocytes to Melanoma: The Progression to Malignancy. Editors: Vincent J. Hearing and Stanley P. L. Leong, Humana Press Inc., Totowa, NJ p591-603, 2005.

Published Abstracts & Scientific Meeting Presentations

  1. Chen KG, Hoeppner DH, Park K, Johnson KR, Mallon B, Garfield SH, Chu V, Carpentier A, Liang, TJ, Robey PG, McKay RD. Rho-associated protein kinase (ROCK) inhibitor Y-27632 abrogates definitive endoderm commitment through distinct p53 signals in human pluripotent stem cells. Poster presentation (W-2014) at the International Society for Stem Cell Research 12th Annual Meeting, June 18-21, 2014, Vancouver, Canada.
  2. Chen KG, Mallon BS, Johnson KR, Hamilton RS, McKay RD, and Robey PG. Optimization of growth models for pluripotent stem cells. Poster presentation at the International Society for Stem Cell Research 11th Annual Meeting, June 12-15, 2013, Boston, MA, USA.
  3. Padmanaban R*, Chen KG*, Gillet JP, Handley M, Mallon BS, Hamilton RS, Park K, Varma S, Mehaffey MG, Robey PG, McKay RD, and Gottesman MM. The role of the ABCG2 ATP-binding cassette transporter in human embryonic stem cells. Poster presentation at the International Society for Stem Cell Research 11th Annual Meeting, June 12-15, 2013, Boston, MA, USA [*equally contributed to this work].
  4. Chen KG, Mallon BS, Hamilton RS, Kozhich O, Park KY, McKay RD. Single-cell-based xeno-free culture of human embryonic stem cells. Poster presentation at the International Society for Stem Cell Research 9th Annual Meeting, June 15-18, 2011, Toronto, Ontario, Canada.
  5. Phillips M, Kuznetsov SA, Cherman N, Park KY, Chen KG, McClendon BN, Hamilton R, Chenoweth J, Mallon B, Robey PG. Osteogenic differentiation of human induced pluripotent stem cells: in vitro and in vivo. International Society for Stem Cell Research 9th Annual Meeting, June 15-18, 2011, Toronto, Ontario, Canada.
  6. Chenoweth JG, Mallon BS, Hamilton RS, Tesar PJ, Chen KG, Park KY, and McKay RD. Studying genetic and epigenetic variation in pluripotent human stem cells. International Society for Stem Cell Research 8 th Annual Meeting, June 16-19, 2010, San Francisco, CA, USA.
  7. Gillet J-P, Rutledge R, Wu CP, Eliseeva, Chen K, Fitzgerald PC, Fales HM, Xia D, Ambudkar SV, Gottesman MM. Characterization of ABCB5, a poorly studied ABC transporter highly expressed in melanomas (abstract# 3881). Proceedings of American Association for Cancer Research 2009
  8. Aszalos A, Taylor B, Yin JJ, Chen KG, Cardarelli, and Gottesman M. Alterations of the biological milieu of membranes induce conformational changes into membrane bound P-glycoprotein. Proceedings of American Association for Cancer Research 47: 298, 2006
  9. Valencia JC, Watabe H, Chi A, Rouzaud F, Chen KG, Vieira WD, Takahashi K, Yamaguchi Y, Berens W, Shabanowitz J, Hunt DF, Appella E, and Hearing VJ. Sorting and trafficking of Pmel17
    (GP100): Evidence for the polarized nature of melanocytes. Pigment Cell Research, 18 (Suppl 1): 29, 2005
  10. ouzaud F, Costin G-E, Yamaguchi Y, Valencia JC, W. Berens, Chen K, Hoashi T, Abdel-Malek A, and Hearing VJ. Expression patterns of MC1R317 and MC1R350 in melanoma cells, normal human melanocytes and skins of various pigmentation/ethnic origin upon stimulation by alpha-MSH/UVR. Pigment Cell Research, 18 (Suppl 1): 21, 2005
  11. Chen KG, Valencia JC, Lai B, Zhang GF, Paterson J, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman R, Hearing VJ, and Gottesman MM. Melanosomal sequestration of cytotoxic drugs contributes to intractability of malignant melanomas. Late-Breaking Abstract (PP087A), 19th International Pigment Cell Conference, Reston, Virginia, USA, September 18-22, 2005
  12. Gottesman MM, Paterson JK, Chen KG, Annereau JP, and Szakacs G. New ABC transporters associated with multidrug resistance in cancer. (Presented in the Budapest International Biochemistry Meeting 2005). FEBS Journal 272: 206, 2005
  13. Chen KG, Kimchi-Sarfaty C, and Gottesman MM. Expression and function of two mRNA isoforms at the locus of the ATP-binding cassette transporter gene ABCB5 in human cancer cells and normal tissues. Proceedings of American Association for Cancer Research 46: 120, 2005
  14. Chen KG, Valencia JC, Liang XJ, Berens W, Paterson J, Rouzaud F, Stephen M. Wincovitch SM, Garfield SH, Vincent J. Hearing VJ, and Gottesman MM. Modulation of melanosomal activity by cisplatin: characterization of a novel cellular machinery that may evade chemosensitivity. Proceedings of American Association for Cancer Research 46: 348, 2005
  15. Duran GE, Francisco EB, Wang YC, Chen KG, Juric D, and Sikic BI. No alterations in C/EBPbeta expression in docetaxel-selected MDR1 (ABCB1) variants derived from human breast cancer cell lines. Proceedings of American Association for Cancer Research 46: 125, 2005
  16. Chen GK, Szakacs G, Annereau J-P, Rouzaud F, Liang X-J, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, and Gottesman MM. Principal expression of two mRNA isoforms (ABCB5alpha and ABCB5beta of the ATP-binding cassette transporter ABCB5, in melanoma cells and in melanocytes. Molecular Biology of the Cell, Suppl. Vol 15: p311a, 2004
  17. Rouzaud F, Costin G-E, Yamaguchi Y, Valencia JC, Chen K, Bohm M, Abdel-Malek AA, and Hearing VJ. Expression patterns of two MC1R isoforms in human melanocytes and skin of various pigmentation/ethnic origin upon stimulation by aMSH/UVR. XIIth Annual Meeting of the Pan American Society for Pigment Cell Research (PASPCR), Abstract # CL-9, 2004
  18. Chen GK, Szakacs G, Annereau J-P, Rouzaud F, Hearing VJ, and Gottesman MM. Principal expression of ABCB5, a novel ATP-Binding cassette transporter, in both melanoma cells and melanocytes. Proceedings of American Association for Cancer Research 45: 569, 2004 (presented in Mini-symposium)
  19. Wang YC, Duran GE, Francisco B, Chen X, Yu RX, Chen GK, and Sikic BI. Mechanisms of MDR1 gene activation in taxane-selected human ovarian carcinoma cell lines. Proceedings of American Association for Cancer Research 44: 387, 2003
  20. Chen GK, Liang XJ, and Sikic BI. Deletion of phenylalanine 335 in the sixth transmembrane domain affects global conformation of P-glycoprotein. Proceedings of American Association for Cancer Research 43: 749, 2003
  21. Chen GK, Schaner ME, Ermoian RP, Wang Y, Mickley LA, Fojo T, and Sikic BI. Capture of upstream sequences and differential transcription start sites for MDR1 activation in human sarcoma cells. Proceedings of American Association for Cancer Research 42: 1107, 2002
  22. Chen GK and Sikic BI. Transcriptional Activation of the MDR1 gene by members of the NF-IL6 family is mediated by the AP-1 and Y-Box associated proteins. Proceedings of American Association for Cancer Research 42: 785, 2001
  23. Lacayo NJ, Amirnazmi S, Kassebaum Chen GK, Duran G, and Sikic BI. Basal and simulated ATPase activity in a mutant P-glycoprotein with a double deletion of phenylalanine 335 and 978. Proceedings of American Association for Cancer Research 42: 920, 2001
  24. Chen GK, Ermoian RP, and Sikic BI. Transcriptional activation or repression of the MDR1 gene by members of the NF-IL6 family. Proceedings of American Association for Cancer Research 41: 866, 2000
  25. Lacayo NJ, Duran GE, Chen GK, and Sikic BI. Basal and stimulated ATPase activity in a mutant P-glycoprotein with a deletion of Phenylalanine. Proceedings of American Association for Cancer Research 40: 662, 1999
  26. Chen G, Lacayo NJ, and Sikic BI. Selective and functional overexpression of mutant allele(s) of the amplified MDR1 gene in human sarcoma drug-resistant variants. Proceedings of American Association for Cancer Research 39: 457, 1998 (presented in Mini-symposium)
  27. Chen G, Duran GE, Mangili A, Beketic-Oreskovic L, and Sikic BI. Vinblastine resistance mechanisms in human sarcoma cells determined by single step selection. Proceedings of American Association for Cancer Research 38: 479, 1997
  28. Chen G, Cohen D, Duran GE, and Sikic BI: Expression and function of a mutant P-glycoprotein which is resistant to modulation by the cyclosporin PSC 833. Proceedings of American Association for Cancer Research 38: 387, 1997
  29. Chen G, Cohen D, Mickley L, Fojo AT, and Sikic BI. Transcriptional repression and activation mdr1 gene in human sarcoma cells. Proceedings of American Association for Cancer Research 38: 442, 1997
  30. Dumontet C, Duran GE, Steger KA, Chen G, and Sikic BI. Resistance to modulation by concurrent exposures to PSC 833 (PSC), doxorubicin, and vincristine. Proceedings of American Association for Cancer Research 37: 329, 1996
  31. Chen G, Duran GE, Steger KA, Lacayo NJ, Jaffrézou J-P, Dumontet C, and Sikic BI: Altered multidrug resistance phenotype and resistance to modulation by the cyclosporin PSC 833 in a deletion mutant (bp 1427-1429), Phenylalanine aa335 of mdr1. Proceedings of American Association for Cancer Research 37: 323, 1996
  32. Beketic-Oreskovic L, Duran GE, Chen G, and Sikic BI: Single-step selection of non-multidrug resistance (non-MDR) mechanisms in human sarcoma mutants derived by co-exposure to doxorubicin (DOX) and SDZ PSC 833 (PSC). Proceedings of American Association for Cancer Research 36: 346, 1995
  33. Chen G, Jaffrezou J-P, Fleming WH, Duran GE, Brophy NA, and Sikic BI. Prevalence of multidrug resistance in human sarcoma mutants derived by single-step doxorubicin (DOX) selection from fluctuation analysis. Proceedings of American Association for Cancer Research 35: 352, 1994
  34. Mogul MJ, Duran GE, Fleming WH, Jaffrezou J-P, Chen G, Brophy NA, and Sikic BI: Resistance to modulation in multidrug resistant (MDR) cells co-selected with cyclosporine and doxorubicin. Proceedings of American Association for Cancer Research 35: 352, 1994
  35. Jaffrezou, J-P, Chen G, Duran GE, Ross K, and Sikic, BI. Mutation rates and mechanism of resistance to etoposide, determined from Luria-Delbruck fluctuation analysis. Proceedings of American Association for Cancer Research 34: 1962, 1993
  36. Chen G, Liu GH, Chen SG et al. Reconstruction of oral cavity defects using the free forearm flap after the radical surgery. The Accumulation of Fourth Stomatological Session of Guangdong Province, Guangzhou, China, p75, 1991
  37. Chen G, Hu YS, Sun BZ, Zhang JQ, and Shu BX. Radionuclide bone scan using SPECT in diagnosis of tumors involving the maxilla and mandible. The Accumulation of the Third National Stomatological Session, Guiyang, China, p120, 1988

Online Database
 
1. Human embryonic stem cell characterization at NIH Stem Cell Unit:
http://stemcells.nih.gov/research/NIHresearch/scunit

GenBank Publication
National Center for Biotechnology Information (NCBI): http://www.ncbi.nlm.nih.gov

  1. Accession number AF345625, Homo sapiens MES-SA/10B-E2 MDR1 mRNA, 5'UTR. NCBI, November 8, 2005
  2. Accession number AF345624, Homo sapiens MES-SA/VL20-4.2 MDR1 mRNA, 5'UTR, NCBI, November 8, 2005
  3. Accession number AF345623, Homo sapiens MES-SA/2B-E3 MDR1 mRNA, 5'UTR. NCBI, November 8, 2005
  4. Accession number AY851365, Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 5 (ABCB5), beta isoform, mRNA, complete cds. NCBI, March 28, 2005
  5. Accession number AY851364, Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 5 (ABCB5), alpha isoform, mRNA, complete cds. NCBI, January 3, 2005
  6. Accession number AF345626, Homo sapiens clone MDRUP2 multidrug-resistance transporter protein (ABCB1) mRNA, 5' UTR. NCBI, March 3, 2004
  7. Accession number AF345337, Homo sapiens clone MDRUP1 multidrug-resistance transporter protein (ABCB1) mRNA, 5' UTR, NCBI, March 3, 2004
  8. Accession number AF342767, Homo sapiens hypothetical drug-resistance-associated protein mRNA, complete cds. NCBI, February 2, 2003
  9. Accession numbers AR051650, AR051649, AR051648, AR051647, Sequence from patent US 5830697. PAT September 29, 1999
  10. Accession number AF016534, Homo sapiens P-glycoprotein (MDR1) gene, exon 10 and partial cds. NCBI, September 16, 1997
  11. Accession number AF016535, Homo sapiens P-glycoprotein (mdr1) mRNA, complete cds. NCBI, September 13, 1997

Invited Lectures

  1. Controlling human embryonic cell stress and growth. Laboratory of Cell Biology, NCI, NIH (guest of Drs. Ettore Appella and Suresh Ambudkar), September 20, 2011
  2. A consensus mechanism for the diversity of cancer drug resistance. Department of Microbiology & Immunology (guest of Dr. Richard Calderone), Georgetown University, October 16, 2010.
  3. Cellular and molecular mechanisms of drug resistance in melanoma. Pigment Research Interest Group, National Cancer Institute, NIH, September 19, 2009.
  4. Genetic and epigenetic modeling of multidrug resistance in melanoma. Wistar Institute (guest of Dr. Meenhard Herlyn), Philadelphia, Pennsylvania, USA, July 2, 2009.
  5. Epigenetic control of multidrug resistance. GTCbio’s 2nd Modern Drug Discovery & Development Summit, Philadelphia, PA, December 4-6, 2006.
  6. East Coast ABC Genes and Diseases Workshop. National Cancer Institute, Frederick, Maryland, USA, October 21, 2004.
  7. Molecular and genetic modeling of multidrug resistant cells in human cancer: the role of ABCB1 (MDR1). Queen’s University, Kingston, Ontario, Canada (guest of Drs. Susan Cole and Roger Deeley), August 17, 2004.
  8. Transcriptional regulation of the multidrug transporter ABCB1. National Cancer Institute, Laboratory of Cell Biology, NCI, NIH (guest of Dr. Michael Gottesman), December 2001.

 

Kevin Gang Chen

Adjunct Associate Professor

 

  • : (301)-402-8118
    Fax: 301-480-1022
  • DEPARTMENTGeorgetown University Medical Center
    Staff Scientist
    NIH Stem Cell Unit
    National Institutes of Health
  • COUNTRY USA