Research Interest

Dr. Guan’s research interests are to elucidate the gut-brain-liver axis in the control of energy balance (feeding behavior, food intake, and gastrointestinal motility) and glycemic control (glucose homeostasis and insulin sensitivity); and to ameliorate glucose intolerance and insulin resistance in obesity and diabetes. Specifically, we wanted to elucidate the functional relevance and signaling network of glucagon-like peptides (GLP-1/2) and receptors in the control of energy balance and glucose homeostasis. Dr. Guan’s recent work is focused on intestinal epithelial adaptation/regeneration and metabolic reprogramming; and hypothalamic-brainstem neuroendocrine control of peripheral glucose/amino acid metabolism. Dr. Guan’s specific aims areto [1] define the physiological function and signaling network of nutrient-responsive gut hormones that control intestinal epithelial homeostasis, absorption and metabolism; and regulate whole-bodyenergy balance and glucose homeostasis; [2] determine the physiological significance of CNS GLP-1/2receptors’activation in the control of glucose homeostasis and energy balance (including feeding behavior, food intake and gastric emptying); and [3] elucidate GLP-1/2-mediated neuroendocrine actions on glucose homeostasis and insulin sensitivityafter bariatric surgery.