Publications

• Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D., Klionsky, D.J., and Y. Ohsumi. 1998. A protein conjugation system essential for autophagy. Nature. 395:395-398.
• George, M.D., Baba, M., Scott, S.V., Mizushima, N., Garrison, B., Ohsumi, Y., and D.J. Klionsky. 2000. Apg5p functions at the sequestration step in the cytoplasm to vacuole targeting and macroautophagy pathways. Mol Biol Cell. 11:969-982.
• Guan J, Stromhaug PE, George MD, Habibzadegah-Tari P, Bevan A, Dunn WA Jr, Klionsky DJ. 2001. Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell. 12(12):3821-38.
• George, M.D., Sanarkan, S., Gelli, A.C., and S. Dandekar. 2003. High throughput gene expression profiling indicates loss of intestinal growth factors and cell cycle mediators during primary simian immunodeficiency virus infection. Virology. 312:84-94.
• Libertini SJ, Robinson BS, Dhillon NK, Glick D, George M, Dandekar S, Gregg JP, Sawai E, Mudryj M. 2005. Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype.Cancer Res. 65(23):10700-8.
• George, M.D., Reay E., Sankaran S., and S. Dandekar. 2005. Early Antiretroviral Therapy for Simian Immunodeficiency Virus Infection Leads to Mucosal CD4+ T-Cell Restoration and Enhanced Gene Expression Regulating Mucosal Repair and Regeneration. J Virol.79:2709-2719.
• Sankaran, S., Guadalupe, M., Reay, E., George, M.D., Flamm, J., Prindiville, T., and S. Dandekar. 2005. Intestinal mucosal T cell responses and gene expression profiles correlate with protection against disese in long-term HIV-1 infected non-progressors. PNAS 102:9860-9865.
• Guadalupe M, Sankaran S, George MD, Reay E, Verhoeven D, Shacklett BL, Flamm J, Wegelin J, Prindiville T, Dandekar S.. 2006. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection.J Virol. 80(16):8236-47.
• Ndolo T, George M, Nguyen H, Dandekar S. 2006. Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion.Virology. 353(2):374-87.
• George M.D., VerhoevenD., McBrideZ.,and DandekarS. 2006. Gene expression profiling of gut mucosa and mesenteric lymph nodes in simian immunodeficiency virus-infected macaques with divergent disease course. Journal of Medical Primatology. 35: 261-269.
• Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, Dandekar S. 2008. Rapid onset of intestinal epithelial barrier dysfunction in primary HIV infection is driven by imbalance between immune response and mucosal repair and regeneration. J Virol. 82(1):538-45
• Raffatellu M, Santos RL, Verhoeven DE, George MD, WilsonRP, WinterSE, Godinez I, SankaranS, PaixaoTA, GordonMA, KollsJK, DandekarS, and Baumler AJ. 2008. Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nature Medicine 14(4):421-428.
• Zhu H, Macal M, Jones CN, George MD, Dandekar S, Revzin A. 2008. A miniature cytometry platform for capture and characterization of T-lymphocytes from human blood.Anal ChimActa.608(2):186-96.
• Asmuth DM, Abel K, George MD, Dandekar S, Pollard RB, Miller CJ. 2008. Pegylated interferon-alpha 2a treatment of chronic SIV-infected macaques.J Med Primatol. 37(1):26-30.
• George MD, Wehkamp J, Kays RJ, Leutenegger CM, Sabir S, Grishina I, Dandekar S, Bevins CL. 2008. In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics. 9(1):209.
• Zhu H, Stybayeva G, Macal M, Ramanculov E, George MD, Dandekar S, Revzin A. 2008. A microdevice for multiplexed detection of T-cell-secreted cytokines.Lab Chip. 8(12):2197-205.
• Godinez I, Haneda T, Raffatellu M, George MD, Paixão TA, Rolán HG, Santos RL, Dandekar S, Tsolis RM, Bäumler AJ. 2008. T cells help to amplify inflammatory responses induced by Salmonella enterica serotype Typhimurium in the intestinal mucosa.Infect Immun. 76(5):2008-17.
• George MD, Verhoeven D, Sankaran S, Dang AT, Dandekar S. 2008. Loss of growth factor receptor signaling in the oral mucosa during primary SIV infection may enhance apoptosis and promote pathogenesis.J Med Primatol. (37) Suppl 2:55-61. NIH: 1R21DE018097
• George MD, Verhoeven D, Sankaran S, Glavan T, Reay E, Dandekar S. 2009. Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. Clin Vaccine Immunol. 16(2):277-81. NIH:1R21DE018097
• Stybayeva G, Zhu H, Ramanculov E, Dandekar S, George M, Revzin A. 2009. Micropatterned co-cultures of T-lymphocytes and epithelial cells as a model of mucosal immune system.BiochemBiophys Res Commun.380(3):575-80.
• Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ. 2009. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.Cell Host Microbe. 5(5):476-86.
• Zhu H, Stybayeva G, Silangcruz J, Yan J, Ramanculov E, Dandekar S, George MD, Revzin A. 2009. Detecting cytokine release from single T-cells.Anal Chem. 81(19):8150-6.
• Dandekar S, George MD, Bäumler AJ. 2010. Th17 cells, HIV and the gut mucosal barrier.Curr Opin HIV AIDS. 5(2):173-8.
• Chen H, Libertini SJ, George M, Dandekar S, Tepper CG, Al-Bataina B, Kung HJ, Ghosh PM, Mudryj M. 2010. Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines.EndocrRelat Cancer. 17(4):857-73.
• Smythies LE, Shen R, Bimczok D, Novak L, Clements RH, Eckhoff DE, Bouchard P, George MD, Hu WK, Dandekar S, Smith PD.2010. Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation. J Biol Chem. 285(25):19593-604.
• Lerner P, Guadalupe M, Donovan R, Hung J, Flamm J, Prindiville T, Sankaran-Walters S, Syvanen M, Wong JK, George MD, Dandekar S. 2011. The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy. J. Virol.85(10):4772-82.
• Dang, AT, Cotton, S, Sankaran-Walters, S, Li, CS, Lee, CY, Dandekar, S,Paster, BJ, George, MD. 2012. Evidence of an increased pathogenic footprintin the lingual microbiome of untreated HIV infected patients. BMC Microbiology. 12:153.
• Libertini SJ, Chen H, al-Bataina B, Koilvaram T, George M, Gao AC, Mudryj M. 2012. The interleukin 6 receptor is a direct transcriptional target of E2F3 in prostate tumor derived cells.Prostate. 72(6):649-60.
• Tang-Feldman YJ, Lochhead SR, Lochhead GR, Yu C, George M, Villablanca AC, Pomeroy C. 2013. Murine cytomegalovirus (MCMV) infection upregulates P38 MAP kinase in aortas of Apo E KO mice: a molecular mechanism for MCMV-induced acceleration of atherosclerosis.J Cardiovasc Transl Res.6(1):54-64.
• Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P. 2013. Circadian clock regulates the host response to Salmonella.Proc Natl Acad Sci.110(24):9897-902.
• Sankaran-Walters S, Macal M, Grishina I, Nagy L, Goulart L, Coolidge K, Li J, Fenton A, Williams T, Miller MK, Flamm J, Prindiville T, George M, Dandekar S. 2013. Sex differences matter in the gut: effect on mucosal immune activation and inflammation.Biol Sex Differ.(1):10.
• Martin ME, Bhatnagar S, George MD, Paster BJ, Canfield DR, Eisen JA, Solnick JV. 2013. The Impact of Helicobacter pylori Infection on the Gastric Microbiota of the Rhesus Macaque. PLoS One. 8;8(10):e76375.
• Ocon S, Murphy C, Dang AT, Sankaran-Walters S, Li CS, Tarara R, Borujerdpur N, Dandekar S, Paster BJ, George MD. 2013. Transcription Profiling Reveals Potential Mechanisms of Dysbiosis in the Oral Microbiome of Rhesus Macaques with Chronic Untreated SIV Infection.PLoS One. 29;8(11):e80863. NIH:5R21DE020025
• Taylor K, Kleinhesselink K, George MD, Morgan R, Smallwood T, Hammonds AS, Fuller PM, Saelao P, Alley J, Gibbs AG, Hoshizaki DK, von Kalm L, Fuller CA, Beckingham KM, Kimbrell DA. 2014. Toll mediated infection response is altered by gravity and spaceflight in Drosophila.PLoS One. 24;9(1):e86485.
• Behnsen J, Jellbauer S, Wong CP, Edwards RA, George MD, Ouyang W, Raffatellu M. 2014. The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria. Immunity 40(2):262-73.
• Verhoeven D, George MD, Hu W, Dang AT, Smit-McBride Z, Reay E, Macal M, Fenton A, Sankaran-Walters S, Dandekar S.2014. Enhanced Innate Antiviral Gene Expression, IFN-α, and Cytolytic Responses Are Predictive of Mucosal Immune Recovery during Simian Immunodeficiency Virus Infection.J Immunol. 192(7):3308-18.
• George MD and Asmuth DM. 2014. Mucosal immunity in HIV infection: What can be done to restore Gastrointestinal-associated lymphoid tissue (GALT) function?. Curr Opin Infect Dis. 27(3):275-81. doi: 10.1097/QCO.0000000000000059.
• Mooney JP, Butler BP, Lokken KL, Xavier MN, Chau JY, Schaltenberg N, Dandekar S, George MD, Santos RL, Luckhart S, Tsolis RM. 2014. The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection.Mucosal Immunol. Mar 26. doi: 10.1038/mi.2014.18. [Epub ahead of print]
• Gaulke CA, Porter M, Han YH, Sankaran-Walters S, Grishina I, George MD, Dang AT, Ding SW, Jiang G, Korf I, Dandekar S. 2014. Intestinal epithelial barrier disruption through altered mucosal microRNA expression in human immunodeficiency virus and simian immunodeficiency virus infections.J Virol. 88(11):6268-80. doi: 10.1128/JVI.00097-14.