Journal Publications

Publications/Presentations

1. Qian, W.; Wang, J.; Roginskaya, V.; McDermott, L. A.; Edwards, R. P.; Stolz, D. B.; Liambi, F.; Green, D. R.; Van Houten, B. “Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells” Oncotarget, 2014, 5(12), 4180-4194.
2. Novitskaya, T.; McDermott, L.; Zhang, K.X.; Chiba, T.; Paueksakon, P.; Hukriede, N.; de Caestecker, M.P. “A PTBA class small molecule enchances recovery and reduces post injury fibrosis after aristolochic acid-induced kidney injury. Am. J. Physiol. Renal
   Physiol. 2014, 306, 496-504.
3. Sanker, S.; Cirio, M. C.; Vollmer, L.L.; Goldberg, N. D.; McDermott, L. A.; Hukriede, N. A.; Vogt, A. “Development of high-content assays for kidney progenitor cell expansion in transgenic zebrafish” J. Biomol. Screen. 2013, 18(10), 1193-202.
4. Cosentino, C. C.; Skrypnyk, N.; Brilli, L. L.; Chiba, T.; Novitskaya, T.; Woods, C.; West, J.; Korotchenko, V.N.; McDermott, L.; Day, B. W.; Davidson, A. J.; Harris, R.; de Caestecker, M. P.; Hukriede. “Histone deacetylase inhibitor enhances recovery after
   AKI” J. Am. Soc. Nephrol. 2013, 24, 943-953.
5. Qian, W.; Roginskaya, V.; Strychor, S.; Beumer, J.; McDermott, L.; Wang, J.; Van Houten, B. “Mitochondrial division inhibitor 1 (mdivi-1) overcomes cisplatin resistance independent of dynamin-related protein 1 (Drp1)” Proceedings of Am. Assoc. Cancer Res., 114th Ann. Meeting, Washington DC, 2013, Abst. 946.
6. Chiba, T.; Novitskaya, T.; Skrypnyk, N.; Harris, R.; McDermott, L.; Hukriede, N.; de Caestecker, M. “Small molecule-mediated enhancement of renal recovery following acute kidney injury”. Mechanisms of Organ Recovery and Regeneration (MORR) Meeting, Ellicott City MD, 2011.
7. Qian, Y.; Wertheimer, S. J.; Ahmad, M.; Cheung, A. W-H.; Firooznia, F.; Hamilton, M. M.; Hayden, S.; Li, S.; Marcopulos, N.; McDermott, L.; Tan, J.; Yun, W.; Guo, L.; Pamidukkala, A.; Chen, Y.; Huang, K-S.; Ramsey, G. B.; Whittard, T.; Conde-Knape, K; Taub, R.; Rodinone, C. M.; Tilley, J.; Bolin, D. “Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes”. J. Med. Chem. 2011, 54, 2433.
8. Bolin, D. R; Olivier, A. R.; Ahmad, M.; Banner, B.; Gillespie, P.; Goodnow, R.; Gubler, M. L.; Hamilton, M. M.; Hayden, S.; Huang, K-S.; Liu, X.; Lou, J. P.; McDermott, L.; Perrotta, A.; Qian, Y.; Rowan, K.; Sergi, J. A.; Thakkar, K.; Yi, L.; Yun, W.; Rondinone, C. M.; Conde-Knape, K.; Tilley, J. W. “ Discovery of Potent, Selective and Orally Efficacious Glycogen Synthase Activators as a Potential Treatment for Type 2 Diabetes.” Proceedings of Am. Chem. Soc. Ann. Meeting, San Fransisco CA, 2010, Abst MEDI 529.
9. Marek, L.; Ware, K. E.; Fritzsche, A.; Hercule, P.; Helton, W. R.; Smith, J. E.; McDermott, L.A.; Christopher, D. C.; Nemenoff, R. A.; Merrick, D. T.; Helfrich, B. A.; Bunn, P. A. Jr.; Heasley, L. E. “Fibroblast Growth Factor (FGF) and FGF Receptor- Mediated Autocrine Signaling in Non-Small Cell Lung Cancer Cells” Molecular Pharmacology, 2009, 75(1), 196.
10. Chen, Y.; Luk, K.; Flynn,T.; McDermott, L; Mallalieu, N.; Morales, O.; Rossman, P.; Simcox, M.; So, S.-S.; Wovkulich, P.; Yang, H.; Wen,Y.; Zhang, Z. “Design, Synthesis and Structure Activity Relationship within a Series of 4-Amino-thienopyridines, Dual KDR/FGFR Tyrosine Kinase Inhibitors” Proceedings of Am. Chem. Soc. Ann. Meeting, San Fransisco CA, 2006, Abst. MEDI 123.
11. McDermott, L. A.; Higgins, B.; Simcox, M.; Luk, K-C.; Nevins, T.; Kolinsky, K.; Smith, M.; Yang, H.; Li, J.-K.; Chen, Y.; Ke, J.; Mallalieu, N.; Egan, T.; Kolis, S.; Railkar, A.; Gerber, L.; Liu, J-J.; Konzelmann, F.; Zhang, Z; Flynn, T.; Morales, O.; Chen, Y.. “Biological Evaluation of a Multi-Targeted Small Molecule Inhibitor of Tumor-Induced Angiogenesis” Bioorg. Med. Chem. Letters. 2006, 16, 1950.
12. McDermott, L. A.; Simcox, M.; Higgins, B.; Nevins, T.; Kolinsky, K.; Smith, M.; Yang, H.; Li, J.; Chen, Y.; Ke, J.; Mallalieu, N.; Egan, T.; Kolis, S.; Railkar, A.; Gerber, L.; Luk, K. “RO4383596, an Orally Active KDR, FGFR, PDGFR Inhibitor. Synthesis and Biological Evaluation”. Bioorg. Med. Chem. 2005, 13, 4835.
13. Rossman, P.; Luk, K.; Chen, Y.; Garofalo, L.; Graves, B.; Jackson, N.; Kabat, M.; Konzelmann, F.; Liu, J.-J.; Lukacs, C.; McDermott, L.; Michoud, C.; Portland, L.; Roberts, J.; Schutt, A.; Simcox, M.; So, S.-S.; Tamborini, B.; Yang, H. “Structure Activity Relationship of C-4-Substituted Pyrimidopyrimidines, Dual KDR/FGFR Tyrosine Kinase Inhibitors”. Proceedings of Am. Chem. Soc. Ann. Meeting, San Diego CA, 2005, Abst. MEDI 124.
14. Simcox, M.; Higgins, B.; McDermott, L. A.; Nevins, T.; Kolinsky, K.; Smith, M.; Yang, H.; Li, J.; Chen, Y.; Ke, J.; Mallalieu, N.; Egan, T.; Kolis, S.; Railkar, A.; Gerber, L.; Luk, K. “Rodent Pharmacokinetic and Antiangiogenic Activity of a Pyrimidopyrimidine Dual KDR/FGFR Antagonist”. Proceedings of EORTC-NCIAACR., 16th Ann. Meeting, Geneva Switzerland, 2004, Abst. 189.
15. Rossman, P.; Luk, K.; Cai, J.; Chen, Y.; Chen, Y.; Daniewski, A.; Dermatakis, A.; Flynn, T.; Garofalo, L.; Gillespie, P.; Goodnow, R.; Graves, B.; Harris, W.; Huby, N.; Jackson, N.; Kabat, M.; Konzelmann, F.; Li, S.; Liu, J.-J.; Liu, W.; Lukacs, C.; Michoud, C.; Perrotta, A.; Portland, L.; Qiao, Q.; Roberts, J.; Schutt, A.; Simcox, M.; So, S.-S.; Tamborini, B.; Toth, K.; Wen, Y.; Xiang, Q.; Yang, H.; Zhang, Z. “Design, Synthesis and Structure Activity Relationship Within A Series of Pyrimidopyrimidine Dual KDR/FGFR Tyrosine Kinase Inhibitors.” Proceedings of Am. Assoc. Cancer Res., 95th Ann. Meeting, Orlando FL, 2004, Abst. 2478.
16. Luk, K.; Simcox, M. E.; Chen, Y.; Schutt, A.; Rowan, K.; Thompson, T.; Kammlott, U.; DePinto, W.; Dunten, P.; Dermatakis A. “A New Series of Potent Oxindole Inhibitors of CDK2” Bioorg. Med. Chem. Letters. 2004, 14, 913.
17. Dermatakis, A.; Thompson, T.; Luk, K.-C.; DePinto, W.; Dunten, P.; Schutt, A.; Rowan, K.; Chen, Y.; Kammlott, U.; Simcox, M. E. “4-Alkynyl Oxindole Inhibitors of Cyclin-Dependent Kinase 2. Design Rationale, Synthesis, and Biochemical Evaluation.” Minisymposium Presentation. Proceedings of Am. Assoc. Cancer Res., 94th Ann. Meeting, Washington DC, 2003, Abst. 3973.
18. Liu, J.-J.; Dermatakis, A.; Lucaks, C.; Konzelmann, F.; Chen, Y.; Kammlot, U.; Depinto, W.; Yang, H.; Yin, X.; Chen, Y.; Schutt, A.; Simcox, M. E.; Luk, K.-C. “3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors” Bioorg. Med. Chem. Letters 2003, 13, 2465.
19. Dermatakis, A.; Luk, K.-C.; DePinto, W. “Synthesis of Potent Oxindole CDK2 Inhibitors.” Biorg. Med. Chem. 2003, 11, 1873.
20. Dermatakis, A. “ATP-competitive inhibitors of cyclin-dependent kinases” Frontiers of Biotechnology and Pharmaceuticals, 2002, Vol 3, 125-156.
21. Parker, K. A.; Dermatakis, A. “Tetrahydroimidazo[1,5,4-ef] [1,5] benzo-diazepinones (isoTIBO's): Synthesis and Evaluation as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.” J. Org. Chem. 1997, 62, 4164-4167.
22. Parker, K. A.; Dermatakis, A. “Enantioselective Synthesis of the Enyne A-Ring Synthon of 1a-Hydroxyvitamins D3.” J. Org. Chem. 1997, 62, 6692-6696.