Bibliographic Production

Books

  • "Host Defenses to Intracellular Pathogens," 1983. T.K. Eisenstein, H. Friedman, and P. Actor (eds.). In Advances in Experimental Medicine and Biology. Plenum Press, New York.
  • "Hepatitis B: The Virus, the Disease, and the Vaccine," 1984. I. Millman, T.K. Eisenstein, and B.S. Blumberg (eds.). Plenum Press, New York.
  • "Host Defenses and Immunomodulation to Intracellular Pathogens," 1988. T.K. Eisenstein, W. Bullock, and N. Hanna (eds.). Plenum Press, New York.
  • "Macrophage-Pathogen Interactions," 1993. B.S. Zwilling and T.K. Eisenstein (eds.). Marcel Dekker, Inc., New York.
  • "The Brain Immune Axis and Substance Abuse," 1995. B. Sharp, T.K. Eisenstein, J. Madden, and H. Friedman (eds.). Plenum Press, New York.
  • "AIDS, Drugs of Abuse, and the Neuroimmune Axis," 1996. H. Friedman, T.K. Eisenstein, J. Madden, and B. Sharp (eds.). Plenum Press, New York.

Report

  • "Opportunities in Microbiology in the Coming Decade." Report of the American Academy of Microbiology, 1997. Co-author of the chapter on Host-Pathogen Interactions.

Invited Editorials and Letters

  • Trends in Microbiology. 1998. Invited Comments on “Intracellular pathogens: the role of antibody-mediated protection in Salmonella infection”. 6:135.
  • Trends in Microbiology .1998. Invited Letter to the Editor on mechanisms of immunity to Salmonella infection. 6:471-472.
  • J. Leukocyte Biology. 2000. Editorial commenting on a review by Mittrucker and Kaufmann on "Immune Response to Infection with Salmonella  typhimurium in Mice" 67: 449.

Papers

  1. Eisenstein, T.K. 1975. Evidence for O antigens as the antigenic determinants in "Ribosomal" vaccines prepared from Salmonella. Infect. Immun. 12:364‑377.
  2. Thompson, H.W.C., and T.K. Eisenstein. 1976. Biological properties of an immunogenic pneumococcal subcellular preparation. Infect. Immun. 13:750‑757.
  3. Eisenstein, T.K., C.R. Angerman, H.C.W. Thompson, and W. Wolde‑Mariam. 1976. Ribosomal vaccines. In Immunologic Aspects of Dental Caries. Proceedings on Selection of Immunogens for a Caries Vaccine, W.H. Bowen et al. (eds.). Suppl. to Immunol. Abstr. pp. 149‑157.
  4. Eisenstein, T.K. 1978. Ribosomal vaccines: A review. In New Trends and Developments on Vaccines, H. Friedman and A. Voller (eds.). MTP Press Ltd., Lancaster, England, pp. 211‑222.
  5. Angerman, C.R., and T.K. Eisenstein. 1978. Comparative efficacy and tox­icity of a ribosomal vaccine, acetone‑killed cells, lipopolysaccharide, and live cell vaccine prepared from Salmonella typhimurium. Infect. Immun. 19:575‑582.
  6. Eisenstein, T.K., and C. Angerman. 1978. Studies on the protective capacity and immuno­genicity of lipopolysaccharide, acetone‑killed cells, and a ribosome‑rich extract of Salmonella typhimurium in C3H/HeJ and CD‑1 mice. J. Immunol. 121:1010‑1014.
  7. Eisenstein, T.K. 1978. Genetic control of immunity to bacterial antigens: An introduction. In Infection, Immunity, and Genetics, H. Friedman et al. (eds.). University Park Press, Baltimore, pp. 21‑23.
  8. Eisenstein, T.K., C.R. Angerman, S. O'Donnell, S. Specter, and H. Friedman. 1980. Relationship between protective immunity, mitogenicity, and B cell activation by Salmonella vaccines. In Macrophages and Lymphocytes, part B, M.R. Escobar and H. Friedman (eds.). Plenum Publishing Corp., pp. 39‑50.
  9. Angerman, C.R., and T.K. Eisenstein. 1980. Immunity to Salmonella infection in mice: correlation of the duration and magnitude of protection to Salmonella infection afforded by various vaccines with antibody titers. Infect. Immun. 27:435‑443.
  10. Carey, R.B., T.K. Eisenstein, G.D. Shockman, T.F. Greber, and R.M. Swenson. 1980. The soluble group‑ and type‑specific antigens from the type III group B Streptococcus. Infect. Immun. 28:195‑203.
  11. Eisenstein, T.K., L.W. Deakins, and B.W. Sultzer. 1980. The C3HeB/FeJ mouse, a strain in the C3H lineage which separates Salmonella suscepti­bility and immunizability from mitogenic responsiveness to lipopolysac­charide. Proc. of an Internat. Symp. on "Genetic Control of Natural Resistance to Infection and Malignancy," ed. E. Skamene, P.A.L. Kongshaven, and M. Landy. Academic Press, New York, pp. 115‑120.
  12. Sultzer, B.M., G.W. Goodman, and T.K. Eisenstein. 1980. Endotoxin protein as an immunostimulant. In Microbiology 1980, D. Schlessinger (ed.). American Society for Microbiology, Washington, D.C., pp. 61‑65.
  13. Au, C.C., and T.K. Eisenstein. 1981. Studies on the nature of the cross‑protective antigen in subcellular vaccines of Streptococcus pneumoniae. Infect. Immun. 31:160‑168.
  14. Au, C.C., and T.K. Eisenstein. 1981. Evaluation of the role of the pneumococcal Forssman antigen (F‑polysaccharide) in the cross‑serotype protection induced by pneumococcal subcellular preparations. Infect. Immun. 31:169‑173.
  15. Butler, R.C., H. Friedman, S.C. Specter, and T.K. Eisenstein. 1981. Induction of immuno­enhancing factors for murine splenocyte cultures by Salmonella typhimurium ribosome and ribonucleic acid extracts. Infect. Immun. 32:1123‑1127.
  16. Eisenstein, T.K. 1981. Immunology. In Highlights in Microbiology 1979‑1980, R.L. Moon and D.D. Whitt (eds.). BET, American Society for Microbiology, Washington, D.C., pp. 26‑28.
  17. Eisenstein, T.K., C.R. Angerman, and L.W. Deakins. 1981. Ribosomal vaccines as immuno­modulators. In Immunomodulation by Bacteria and Their Products, H. Friedman, T. Klein and A. Szentivanyi (eds.). Plenum Press, New York, pp. 423‑428.
  18. Eisenstein, T.K., R.B. Carey, G.D. Shockman, S.M. Smith, and R.M. Swenson. 1982. Automated ELISA determination of antibody responses in human volunteers immunized with a highly purified, soluble Group B streptococcal Type III polysaccharide. In Bacterial Vaccines, J. Robbins, J. Hill, J. Sadoff (eds.). Thieme‑Stratton, New York, pp. 280‑284.
  19. Eisenstein, T.K., and B. Sultzer. 1982. Salmonella vaccines: Protection by endotoxin protein and lipopolysaccharide in two different mouse strains. In Bacterial Vaccines, J. Robbins, J. Hill, J. Sadoff (eds.). Thieme‑Stratton, New York, pp. 423‑428.
  20. Eisenstein, T.K., L.W. Deakins, L. Killar, P. Saluk, and B.M. Sultzer. 1982. Dissociation of innate susceptibility to Salmonella infection and endotoxin responsiveness in C3HeB/FeJ mice and other mouse strains in the C3H lineage. Infect. Immun. 36:646‑703.
  21. De Cueninck, B., T.K. Eisenstein, T.S. McIntosh, G.D. Shockman, and R.M. Swenson. 1982. Type‑specific protection of neonatal rats from lethal Group B Streptococcal infection by immune sera obtained from human volunteers vacci­nated with the Type III‑specific polysaccharide. Infect. Immun. 37:961‑965.
  22. De Cueninck, B.J., T.K. Eisenstein, T.S. McIntosh, G.D. Shockman, and R.M. Swenson. 1983. Quantitation of in vitro opsonic activity of human antibody induced by a vaccine consisting of the Type III‑specific polysaccharide of Group B streptococcus. Infect. Immun. 39:1155‑1160.
  23. Killar, L., and T.K. Eisenstein. 1983. Strain dependent variation of delayed‑type hypersensitivity in Salmonella typhimurium infected mice. In Host Defenses to Intracellular Pathogens, T.K. Eisenstein, H. Friedman, and P. Actor (eds.). Plenum Press, New York, pp. 297‑302.
  24. Eisenstein, T.K., and B.M. Sultzer. 1983. Immunity to Salmonella Infection. In Host Defenses to Intracellular Pathogens, T.K. Eisenstein, H. Friedman, and P. Actor (eds.). Plenum Press, New York, pp. 261‑296.
  25. Eisenstein, T.K., B.J. De Cueninck, D. Resavy, G.D. Shockman, R.E. Carey, and R.M. Swenson. 1983. Quantitative determination in human sera of vaccine‑induced antibody to type‑specific polysaccharides of Group B streptococci using an enzyme‑linked immunosorbant assay. J. Inf. Dis. 147:847‑856.
  26. De Cueninck, B.J., T.F. Greber, T.K. Eisenstein, R.M. Swenson, and G.D. Shockman. 1983. Isolation, chemical composition, and molecular size of extracellular type II‑ and type Ia‑polysaccharides of Group B streptococci. Infect. Immun. 41:527‑534.
  27. Linares, A.P., S.H. Cohen, E. Goldstein, A.D. Kelley, and T.K. Eisenstein. 1984. Febrile gastroenteritis due to Salmonella thompson: Report of an outbreak. West. J. Med. 141:203‑205.
  28. Eisenstein, T.K., R. Tamada, and J. Meissler. 1984. Legionella vaccine studies in guinea pigs: Protection against intraperitoneal but not aerosol infection. In Proceedings of the Second International Symposium on Legionella, C. Thornsberry, A. Balows, J.C. Feeley, and W. Jakubowski (eds.). Am. Soc. Microbiol., Washington, D.C., pp. 194‑195.
  29. Eisenstein, T.K., R. Tamada, J. Meissler, A. Flesher, and H.C. Oels. 1984. Vaccination against Legionella pneumophila: Serum antibody correlates with protection induced by heat‑killed or acetone‑killed cells against intraperitoneal but not aerosol infection in guinea pigs. Infect. Immun. 45:685‑691.
  30. Eisenstein, T.K., L.M. Killar, B.A.D. Stocker, and B.M. Sultzer. 1984. Cellular immunity induced by avirulent Salmonella in LPS‑defective C3H/HeJ mice. J. Immunol. 133:958‑961.
  31. Eisenstein, T.K., L.M. Killar, and B.M. Sultzer. 1984. Immunity to infection with Salmonella typhimurium: Mouse strain differences in vaccine‑ and serum‑mediated protection. J. Inf. Dis. 150:425‑433.
  32. Killar, L.M., and T.K. Eisenstein. 1984. Differences in delayed‑type hypersensitivity responses in various mouse strains in the C3H lineage infected with Salmonella typhimurium, strain SL3235. J. Immunol. 133:1190‑1196.
  33. Eisenstein, T.K., and H. Friedman. 1985. Immunity to Legionella. In Legionellosis II, S. Katz (ed.). CRC Press, FL, pp. 159‑181.
  34. Swenson, R.M., T.K. Eisenstein, and G.D. Shockman. 1985. The soluble antigens of the Group B Streptococcus as human vaccines. Antibiot. Chemother. 35:291‑295.
  35. Lee, J.‑C., C. Gibson, and T.K. Eisenstein. 1985. Macrophage‑mediated mitogenic suppression induced in mice of the C3H lineage by a vaccine strain of Salmonella typhimurium. Cell. Immunol. 91:75‑91.
  36. Killar, L.M., and T.K. Eisenstein. 1985. Immunity to Salmonella infection in C3H/HeJ and C3H/HeNCrlBR mice: Studies using an aromatic‑dependent live Salmonella strain as a vaccine. Infect. Immun. 47:605‑612.
  37. Phillips, M., T.K. Eisenstein, and J. Meissler. 1985. Immunomodulation of the antibody response to LPS in C3H/HeJ mice by complexing with heterologous ribosomes. Infect. Immun. 48:244‑247.
  38. Killar, L.M., and T.K. Eisenstein. 1986. Delayed‑type hypersensitivity and immunity to Salmonella typhimurium. Infect. Immun. 52:504‑508.
  39. Rosenfeld, J.S., F. Kueppers, T. Newkirk, R. Tamada, J.J. Meissler, Jr., and T.K. Eisenstein. 1986. A protease from Legionella pneumophila with cytotoxic and dermal ulcerative activity. FEMS Microbiol. Lett. 37:51‑58.
  40. Eisenstein, T.K., L.M. Killar, B.M. Sultzer, and M. Phillips. 1986. Salmonella antigens as protective immunogens in Salmonella infection. In Immunobiology and Immunopharmacology of Bacterial Endotoxins, A. Szentivanyi and H. Friedman (eds.). Plenum Publishing Corp., New York.
  41. Eisenstein, T.K., N. Dalal, L. Killar, J.‑C. Lee, and R. Schafer. 1988. Paradoxes of immunity and immunosuppression in Salmonella infection. In Host Defenses and Immunomodulation to Intracellular Pathogens, T.K. Eisenstein, W. Bullock, and N. Hanna (eds.). Plenum Publishing Corp., New York.
  42. Schafer, R., C.A. Nacy, and T.K. Eisenstein. 1988. Induction of activated macrophages in C3H/HeJ mice by avirulent Salmonella. J. Immunol. 140:1638‑1644.
  43. Phillips, M., B.M. Sultzer, R. Castagna, and T.K. Eisenstein. 1989. Immunogenic endotoxin associated protein from a rough strain of Salmonella. FEMS Microbiol/Immunol. 47:485‑490.
  44. Lynch, T.J., M.W. Adler, and T.K. Eisenstein. 1990. Comparison of the mechanisms of IL‑1 and morphine‑induced hyperthermia in the rat. In Proceedings of the New York Academy of Sciences, "Neuropeptides and Immuno­peptides: Messengers in a Neuroimmune Axis," M.S. O'Dorisio and A. Panerai (eds.). New York Academy of Sciences, New York, pp. 469‑471.
  45. Eisenstein, T.K., J.J. Meissler, Jr., E.B. Geller, and M.W. Adler. 1990. Immunosuppression to tetanus toxoid induced by implanted morphine pellets. In Proceedings of the New York Academy of Sciences, "Neuropeptides and Immunopep­tides: Messengers in a Neuroimmune Axis," M.S. O'Dorisio and A. Panerai (eds.). New York Academy of Sciences, New York, pp. 373‑379.
  46. Eisenstein, T.K., M. Brodkin, J.M. Greene, S. Trajkovic, B. Al‑Ramadi, and J.J. Meissler, Jr. 1990. Immunosuppression induced by lipopolysaccharide and by live and killed Salmonella. In Cellular and Molecular Aspects of Endotoxin Reactions, A. Nowotny, J.J. Spitzer, and E.J. Ziegler (eds.). Elsevier, Amsterdam, pp. 371‑377.
  47. Taub, D.D., T.K. Eisenstein, E.B. Geller, M.W. Adler, and T.J. Rogers. 1991. Immuno­modulatory activity of ‑ and ‑selective opioid agonists. Proc. Natl. Acad. Sci. USA 88:360‑364.
  48. Al‑Ramadi, B.K., M.A. Brodkin, D.M. Mosser, and T.K. Eisenstein. 1991. Immuno­sup­pres­­sion induced by attenuated Salmonella: Mediation by macrophage precursors. J. Immu­nol. 146:2737‑2746.
  49. Eisenstein, T.K., D.D. Taub, T.J. Rogers, and M.W. Adler. 1991. The effect of morphine and DAGO on the proliferative response of murine splenocytes. In Drugs of Abuse, Immunity, and Immunodeficiency, H. Friedman, S. Specter, and T. Klein (eds.). Plenum Press, New York, p. 203‑209.
  50. Al‑Ramadi, B.K., Y.‑W. Chen, and T.K. Eisenstein. 1991. Immunosuppression induced by attenuated Salmonella: Reversal by IL‑4. J. Immunol. 147:1954‑1961.
  51. Wu, L., T.K. Eisenstein, and P.S. Morahan. 1992. Effect of herpes simplex virus type 1 infection on cytokine gene expression in activated murine peritoneal macrophages. In Innovations in Antiviral Development and the Detection of Virus Infection, L. Walsh, T. Block, R.L. Crowell, and D.L. Jungkind (eds.). Adv. Exp. Biol. Med. 312:167-172.
  52. Schafer, R., and T.K. Eisenstein. 1992. Natural killer cells mediate protection induced by aroA- Salmonella. Infect. Immun. 60:791-797.
  53. Al‑Ramadi, B.K., J.M. Greene, J.J. Meissler, Jr., and T.K. Eisenstein. 1992. Attenuated Salmonella induce immunosuppression in LPS‑responder mice: C3H/HeJ mice have a dose‑dependent defect in the development of suppression. Microbial Pathogen. 12:267‑278.
  54. Bussiere, J.L., M.W. Adler, T.J. Rogers, and T.K. Eisenstein. 1992. Differential effects of morphine and naltrexone on the antibody response in various mouse strains. Immunopharmacol. Immunotoxicol. 14:657-673.
  55. Al‑Ramadi, B.K., J.J. Meissler, Jr., D. Huang, and T.K. Eisenstein. 1992. Immuno­suppression induced by nitric oxide and its inhibition by IL‑4. Eur. J. Immunol. 22:2249-2254.
  56. Bussiere, J.L., M.W. Adler, T.J. Rogers, and T.K. Eisenstein. 1992. Effects of in vivo morphine treatment on antibody responses in C57Bl/6 bgJ/bgJ (beige) mice. Life Sci. 52:43-48.
  57. Bussiere, J.L., M.W. Adler, T.J. Rogers, and T.K. Eisenstein. 1993. Cyto­kine reversal of morphine‑induced suppression of the antibody response. J. Pharmacol. Exp. Therapeut. 264:591-597.
  58. Bussiere, J.L., D.D. Taub, J.J. Meissler, Jr., M.W. Adler, T.J. Rogers, and T.K. Eisenstein. 1993. Effects of opioids on murine antibody responses. Adv. Biosci. 86:563-572.
  59. Adler, M.W., E.B. Geller, T.J. Rogers, E.E. Henderson, and T.K. Eisenstein. 1993. Opioids, receptors, and immunity. In Drugs of Abuse, Immunity, and AIDS, H. Friedman, S. Specter, and T. Klein (eds.). Plenum, New York, p. 13-20.
  60. Eisenstein, T.K., J.L. Bussiere, T.J. Rogers, and M.W. Adler. 1993. Immunosuppressive effects of morphine. In Drugs of Abuse, Immunity, and AIDS, H. Friedman, S. Specter, and T. Klein (eds.). Plenum, New York, p. 41-52.
  61. Rojavin, M., I. Szabo, J.L. Bussiere, T.J. Rogers, M.W. Adler, and T.K. Eisenstein. 1993. Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages. Life Sci. 53:997-1006.
  62. Szabo, I., M. Rojavin, J.L. Bussiere, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1993. Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids. J. Pharmacol. Exp. Therapeut. 267:703-706.
  63. Eisenstein, T.K., B.K. Al-Ramadi, D. Huang, R. Schafer, L. Killar, J.-C. Lee, and J.J. Meissler, Jr. 1993. Immunity and immunosuppression induced by attenuated Salmonel­la: The role of nitric oxide. In F. Cabello, C. Hormaeche, P. Mastroenni, and L. Bonina (eds.), Biology of Salmonella, a NATO Advanced Research Workshop. Plenum Press, New York, p. 265-277.
  64. Eisenstein, T.K. 1993. Suppressor macrophages. In B. Zwilling and T.K. Eisenstein (eds.), Macrophage-pathogen interactions. Marcel-Dekker, New York, p. 203-224.
  65. Wu, L., P.S. Morahan, J.A. Hendrzak, and T.K. Eisenstein. 1994. Herpes simplex virus type 1 replica­tion and IL‑1 gene expression in mouse peritoneal macrophages activated in vivo by an attenuated Salmonella typhimurium vaccine or Corynebacterium parvum. Microbial Pathogen. 16:387-399.
  66. Eisenstein, T.K., D. Huang, J.J. Meissler, Jr., and B. Al‑Ramadi. 1994. Macrophage nitric oxide mediates immunosuppression in infectious inflammation. Immunobiology 191:493-502.
  67. Guan, L., R. Townsend, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1994. Both T‑cells and macrophages are targets of kappa opioid-induced immunosuppression. Brain, Behavior and Immunity 8:229-240.
  68. Wallace, P.K., Meissler, J.J., Jr., Eisenstein, T.K. and Morahan, P.S. 1995. Decreases in macrophage mediated antitumor activity with aging. Mechanisms in Aging and Development 77:169-184.
  69. Eisenstein, T.K., J.J. Meissler, Jr., J.L. Bussiere, T.J. Rogers, E.B. Geller, and M.W. Adler. 1995. Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids. In B. Sharp, T.K. Eisenstein, J. Madden, and H. Friedman (eds.), The Brain Immune Axis and Substance Abuse. Plenum Press, New York, pgs. 115-121.
  70. Belkowski, S.M., J. Zhu, L.Y. Liu-Chen, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1995. Detection of ‑opioid receptor mRNA in immature T cells. In B. Sharp, T.K. Eisenstein, J. Madden, and H. Friedman (eds.), The Brain Immune Axis and Substance Abuse. Plenum Press, New York, pgs. 11-16.
  71. Guan, L., R. Townsend, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1995. The cellular basis for opioid-induced immunosuppression. In B. Sharp, T.K. Eisenstein, J. Madden, and H. Friedman (eds.), The Brain Immune Axis and Substance Abuse. Plenum Press, New York, pgs. 57-64.
  72. Belkowski, S.M., C. Alicea, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1995. Inhibition of interleukin-1 and tumor necrosis factor- synthesis following treatment of macrophages with the kappa opioid agonist U50,488H. J. Pharmacol. Exp. Therap. 273:1491-1496.
  73. Eisenstein, T.K., B. Bushnell, J.J. Meissler, Jr., N. Dalal, R. Schafer, and H.F. Havas. 1995. Immunotherapy of a plasmacytoma with attenuated Salmonella. Med. Oncol. 12:103-108.
  74. Belkowski, S.M., J. Zhu, L.-Y. Liu-Chen, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1995. Sequence of -opioid receptor cDNA in the R1.1 cell line. J. Neuroimmunol. 62:113-117.
  75. Eisenstein, T.K., M.E. Hilburger, and D.M.P. Lawrence. 1995. Immunomodulation by morphine and other opioids. In H. Friedman, T.W. Klein, and S. Specter (eds.), Drugs of Abuse, Immunity and Infections. CRC Press, New York, pp. 103-120.
  76. Eisenstein, T.K., J.J. Meissler, Jr., T.J. Rogers, E.B. Geller, and M.W. Adler. 1995. Mouse strain differences in immunosuppression by opioids in vitro. J. Pharmacol. Exp. Therap. 275:1484-1489.
  77. Alicea, C., S.M. Belkowski, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1996. Inhibition of primary macrophage cytokine production following treatment with the ‑opioid agonist U50,488H. J. Neuroimmunol. 64:83-90.
  78. Sharp, B.M., and T.K. Eisenstein. 1996. Expression of opioid receptors by immune cells. J. Neuroimmunol. 69:3-13.
  79. Eisenstein, T.K., D. Huang, and M.G. Schwacha. 1996. Immunity to Salmonella Infections. In L.J. Paradise et al. (eds.), Enteric Infections and Immunity. Plenum Press, New York, pp. 57-78.
  80. Huang, D., M.G. Schwacha, and T.K. Eisenstein. 1996. Attenuated Salmonella vaccine induced suppression of murine spleen cell mitogen responses is mediated by macrophage nitric oxide: quantitative aspects. Infect. Immun. 64:3786-3792.
  81. Eisenstein, T.K., M.G. Schwacha, D. Huang, and J.J. Meissler, Jr. 1997. Attenuated Salmonella used as vaccines are immunosuppressive by macrophage-mediated production of nitric oxide. In G.T. Keusch and M. Kawakami (eds.), Cytokines, Cholera and the Gut, pp. 353-359.
  82. Hilburger, M.E., M.W. Adler, A.L. Truant, J.J. Meissler, Jr., V. Satishchandran, T.J. Rogers, and T.K. Eisenstein. 1997. Morphine induces sepsis in mice. J. Inf. Dis. 176:183-188.
  83. Guan, L., T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1997. Inhibition of T cell superantigen responses following treatment with the -opioid agonist U50,488H. J. Neuroimmunol. 75:163-168.
  84. Hilburger, M.E., M.W. Adler, T.J. Rogers, and T.K. Eisenstein. 1997. Morphine alters macrophage and lymphocyte populations in the spleen and peritoneal cavity. J. Neuroimmunol. 80:106-114.
  85. Schwacha, M.G., and T.K. Eisenstein. 1997. Interleukin-12 is critical for the induction of nitric oxide-mediated immunosuppression following vaccination of mice with attenuated Salmonella typhimurium. Infect. Immun. 65:4897-4903.
  86. Eisenstein, T.K., J.J. Meissler, Jr., B.A.D. Stocker, and S.I. Miller. 1998. Immunosuppression and nitric oxide induced by attenuated Salmonella vaccines do not correlate with protective capacity: a phoP‑ mutant does not suppress but does protect. Vaccine 16:24-32.
  87. Eisenstein, T.K., and M.E. Hilburger. 1998. Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations. J. Neuroimmunol. 83:36-44.
  88. Le, Q., R. Daniel, S.-W. Chung, A.D. Kang, T.K. Eisenstein, B.M. Sultzer, H. Simpkins, and P.M.C. Wong. 1998. Involvement of C-Abl tyrosine kinase in lipopolysaccharide-induced macrophage activation. J. Immunol. 160:3330-3336.
  89. Eisenstein, T.K., T.J. Rogers, J.J. Meissler, Jr., M.W. Adler, and M.E. Hilburger. 1998. Morphine depresses macrophage numbers and function in mouse spleens. In H. Friedman, T.K. Eisenstein, J. Madden, and T. Klein (eds.), Drugs of Abuse, Immunomodulation and AIDS. Plenum Press, New York, p. 33-41.
  90. Guan, L., T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1998. Modulation of DPK cell function by the -opioid agonist U50,488H. In H. Friedman, T. Eisenstein, J. Madden, and T. Klein (eds.), Drugs of Abuse, Immunomodulation, and AIDS. Plenum Press, New York, pp. 125-136.
  91. Alicea, C., S.M. Belkowski, J. Sliker, J. Zhu, L.-Y. Liu-Chen, T.K. Eisenstein, M.W. Adler, and T.J. Rogers. 1998. Characterization of -opioid receptor transcripts expressed by T cells and macrophages. J. Neuroimmunol. 91:55-62.
  92. Schwacha, M.G., J.J. Meissler, Jr., and T.K. Eisenstein. 1998. Salmonella typhimurium infection in mice induces nitric oxide-mediated immunosuppression through a natural killer cell-dependent pathway. Infect. Immun. 66:5862-5866.
  93. MacFarlane, A.S., D. Huang, M.G. Schwacha, J.J. Meissler, Jr., J.P. Gaughan, and T.K. Eisenstein. 1998. Nitric oxide mediates immunosuppression induced by Listeria monocytogenes infection: quantitative studies. Microbial Pathogen. 25:267-277.
  94. MacFarlane, A.S., M.G. Schwacha, and T.K. Eisenstein. 1999. In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression induced by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen. Infect. Immun. 67:891-898.
  95. Eisenstein, T.K. 1999. Mucosal immune defense: the Salmonella typhimurium model. In Y. Paterson (ed.), Intracellular Bacteria as Live Recombinant Vaccine Vectors. J. Wiley & Sons, Inc., New York, pp. 51-109.
  96. MacFarlane, A.S., X. Peng, J.J. Meissler, Jr., T.J. Rogers, E.B. Geller, M.W. Adler, and T.K. Eisenstein. 2000. Morphine increases susceptibility to oral Salmonella typhimurium infection. J. Infect. Dis. 181:1350-1358.
  97. Ni, X., K.R. Gritman, T.K. Eisenstein, M.W. Adler, K.E. Arfors, and R.F. Tuma. 2000. Morphine attenuates leukocyte/endothelial interactions. Microvas. Res. 60:121-130.
  98. Peng, X., D.M. Mosser, M.W. Adler, T.J. Rogers, J.J. Meissler, Jr., and T.K Eisenstein. 2000. Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages. J. Leukoc. Biol. 68:723-728.
  99. Wetzel, M.A., A.D. Steele, T.K. Eisenstein, M.W. Adler, E.E. Henderson, and T.J. Rogers. 2000. m-Opioid modulation of Monocyte Chemoattractant Protein-1 (MCP-1), RANTES, and IFN-g Inducible Protein-10 (IP-10) expression in human PBMCs. J. Immunol. 165:6519-6524.
  100. McCarthy L., M. Wetzel, J.K. Sliker, T.K. Eisenstein, and T.J. Rogers. 2001. Opioids, opioid receptors, and the immune response: a review. Drug Alcohol Depend. 62:111-123.
  101. Eisenstein, T.K. 2001. Are the neuroimmune connections related to drug abuse important in humans? Problems of Drug Dependence 2000. NIDA Monograph, ed. L. Harris. 181:56-61.
  102. Daniel, R., S.-W.Chung, T.K. Eisenstein, B.M. Sultzer, and P.M.C. Wong. 2001. Specific association of Type I c-Abl with Ran GTPase in lipopolysaccharide-mediated differentiation. Oncogene. 20:2618-2625.
  103. Peng, X., J.J. Cebra, M.W. Adler, J.J. Meissler, Jr., A. Cowan, and T.K. Eisenstein. 2001. Morphine inhibits mucosal antibody responses and TGF-b mRNA in Gut-Associated Lymphoid Tissue (GALT) following oral cholera toxin in mice. J. Immunol. 167:3677-3681.
  104. Rahim, R.T., J.J. Meissler, Jr., A. Cowan, T.J. Rogers, E.B. Geller, J. Gaughan, M.W. Adler, and T.K. Eisenstein. 2001. Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses. Internat. Immunopharm. 1:2001-2009.
  105. Eisenstein, T.K., B. Al-Ramadi, D. Huang, A.S. MacFarlane, M. Schwacha, and J.J. Meissler, Jr. 2001. Immune responses and side effects of various Salmonella vaccines: Which one is best? Typhoid Fever and other Salmonellosis. J. Ou, C-H Chiu, and C. Chu (eds), Jeou-Chou Book Co., Ltd., Taipei, Taiwan, pgs. 231-255.
  106. Eisenstein, T.K., A.S. MacFarlane, X. Peng, M. Hilburger, R. Rahim, J.J. Meissler, Jr., A. Cowan, T.J. Rogers, and M.W. Adler. 2001. Effect of opioids on oral Salmonella infection and immune function. In Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases, H. Friedman, J. Madden, and T. Klein (eds). Kluwer Academic/Plenum Press, New York, pgs. 169-176.
  107. Eisenstein, T.K. 2001. Implications of Salmonella-induced  nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppresive, and immunoregulatory molecule. Microbes and Infection. 3:1223-1231.
  108. Eisenstein, T.K., J.J. Meissler, Jr., E. B. Geller, L-Y Liu-Chen, T.J. Rogers, and M.W. Adler. 2002. Nociceptin as an immunoregulatory peptide. NIDA monographs,182:97-100.
  109. Rahim, R.T., M.W. Adler, J.J. Meissler, Jr., A. Cowan, T.J. Rogers, E.B. Geller, and
  110. T.K. Eisenstein. 2002. Abrupt or precipitated withdrawal from morphine induces immunosuppression. J. Neuroimmunol. 127:88-95.
  111. Rahim, R. T., J. J. Meissler, Jr., L. Zhang, M. W. Adler, T. J. Rogers, and T. K. Eisenstein.            2003. Withdrawal from morphine in mice suppresses splenic macrophage function, cytokine        production, and costimulatory molecules. J. Neuroimmunology. 144:16-27.
  112. Eisenstein, T. K., R.T. Rahim,  P. Feng, and Martin W. Adler. 2004. Paradoxes of             immunosuppression in mouse models of withdrawal.  J. Neuroimmunol. 147:114-120.
  113. Ni, X., Geller, EB., Eppihimer,M.J., Eisenstein,T.K., Adler,M.W., Tuma,R.F. Win 55212-2,          a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an    experimental autoimmune encephalomyelitis model. Multiple Sclerosis 10:158-164, 2004
  114. Rogers, T.J., F. Bednar, D.E. Kaminsky, P.C. Davey, J.J Meissler, Jr., and T.K.Eisenstein. 2005. Laboratory Model Systems of Drug Abuse and their Relevance to HIV Infection and Dementia. In “The Neurology of AIDS, 2nd Ed”. ed. H. Gendelman, I. Grant, I. Everall, S. Lipton, and S. Swindells. Oxford University Press. pgs. 309-320 .
  115. Rahim, R. T., J. J. Meissler, Jr., T. J. Rogers, M. W. Adler, and T. K. Eisenstein. 2005.       Splenic macrophages and B-cells mediate immunosuppression following abrupt withdrawal           from morphine. J. Leuk. Biol. 78:1185-91.
  116. Feng, P., Q. Wilson, J.J Meissler, Jr., M.W. Adler, and T.K. Eisenstein. 2005. Increased    sensitivity to             Salmonella infection in mice undergoing withdrawal from morphine is        associated with suppression of IL-12. Infect. Immun. 73:7953-59.
  117. Feng, P., R.T. Rahim, A. Cowan, L-Y. Liu-Chen, X. Peng, J.J. Meissler, M. W. Adler, and           T.K. Eisenstein. 2006. Effects of mu, kappa or delta opioids administered by pellet or pump     on oral Salmonella infection and gastrointestinal transit. Eur. J. Pharmacology. 534:250-256.
  118. Eisenstein, T.K., R.T. Rahim, P. Feng, N.K. Thingalaya, and J.J. Meissler. 2006. Effects of           opioid tolerance and withdrawal on the immune system. J. Neuroimmune Pharm. 1:237-249.
  119. Feng, P., A. L. Truant, J. J. Meissler, J. P. Gaughan, M. W. Adler, and T. K. Eisenstein. 2006.
  120. Morphine withdrawal lowers host defense to enteric bacteria: Spontaneous sepsis and       increased sensitivity to oral Salmonella enterica serovar Typhimurium. Infect. Immun.           74:5221
  121. Benamar, K., M. Yondorf, J. J. Meissler, E. B. Geller, R.J. Tallarida, T. K. Eisenstein, and            M.W. Adler. 2007. A novel role of cannabinoids: Implication in the fever induced by bacterial    lipopoysaccharide. J. PET. 320. 1127-1133
  122. Eisenstein, T.K. D.E. Kaminsky, R. T. Rahim, and T. J. Rogers. 2008. Drugs of Abuse and the     Immune system. In, “NeuroImmune Pharmacology”, ed. T. Ikezu and H. E. Gendelman,     Springer. N.Y.  531-539.
  123. Eisenstein, T.K., J.J. Meissler, Q.Wilson, Jr., J.P. Gaughan, M.W. Adler. 2007. Anandamide         and 9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. J.       Neuroimmunol. 189:17-22
  124. Anton, B., P. Leff, J. C. Calva, R. Acevedo, A. Salazar, M. Matus, L. Pavon, M. Martinez, J.J. Meissler, M. W. Adler, J. P. Gaughan, T. K. Eisenstein. 2008. Endomorphin 1 and    endomorphin 2 suppress in vitro antibody formation at ultra-low concentrations: Anti-peptide antibodies but not opioid antagonists block the activity. Brain, Behavior, and Immunity. 22: 824-832.
  125. Benamar, K, M. Yondorf, E.B. Geller, T. K. Eisenstein, and M. W. Adler. 2009. Physiological evidence for interaction between the HIV-1 co-receptor CXCR4 and the cannabinoid system in the brain. Br. J. Pharm. 157:1225-1231.
  126. Benamar K, Addou S, Yondorf M, Geller EB, Eisenstein TK, Adler MW. 2010. Intrahypothalamic injection of the HIV-1 envelope glycoprotein induces fever via interaction with the chemokine system. J Pharmacol Exp Ther 332:549-53
  127. Anton, B., P. Leff, J. J. Meissler, J. C. Calva, R. Acevedo, A. Salazar, M. Matus, A. Flores,  M. Martinez, M. W. Adler, J. P. Gaughan, T. K. Eisenstein. 2010. Nociceptin/Orphanin FQ    suppresses adaptive immune responses in vivo and at picomolar levels in vitro. J.          Neuroimmune Pharm. 5143-154. PubMed PMID: 20119853. NIHMS ID: 573436
  128. Breslow, J.M., P. Feng, J.J. Meissler, J.E. Pintar, J. Gaughan, M.W. Adler, T.K. Eisenstein. 2010.  Potentiating effect of morphine on oral Salmonella enterica, serovar Typhimurium infection is mu-opioid receptor dependent. Microbial Pathogenesis. 49:330-335.
  129. Breslow, J.M., J.J. Meissler, R.R. Hartzell, P.B. Spence, A. Truant, J. Gaughan, T.K.Eisenstein. 2011. Innate immune responses in systemic Acinetobacter baumannii infection in mice: Neutrophils, but not IL-17, mediate host resistance. Infect. Immun. 79:3317-3327.
  130. Eisenstein, T.K., J. Breslow, C. Song, M.J. Finley, W. Cornwell,  S. Chugh,  J.J. Meissler, and T. J. Rogers. 2011. “HIV and Opioids”, in “Neurology of AIDS, 3rd Ed”. ed. H. Gendelman, I. Grant, I.P. Everall, H. Glebard, H.S. Fox., S.A.Lipton, and S. Swindells. Oxford University Press. pgs. 338-353.
  131. Breslow, J.M., M.A. Monroy, J.J. Meissler, , J. Gaughan, M.W. Adler, T.K. Eisenstein. 2011. Morphine, but not trauma, sensitizes to systemic Acinetobacter baumannii infection. J. of NeuroImmune Pharm. 6:551- 565. 2011. PMCID: 2956788. PMID: 21824605.
  132. Chen, X., L.G. Kirby, J. Palma, K. Benamar, E.B. Geller, T.K. Eisenstein, M.W. Adler. 2011. The effect of gp120 on morphine’s antinociceptive and neurophysiological actions. Brain, Behavior, and Immunity. 25(7):1434-43, 2011. [Epub May 5] PMID: 21569838.
  133. Eisenstein, T.K. 2011. Opioids and the immune system: what is their mechanism of action? Br. J. of Pharm. 164:1826-28. (Invited Commentary)
  134. Robinson, R.H., Meissler, J.J., Breslow-Deckman, J.M., Gaughan, J., Adler, M.W., Eisenstein, T.K. 2013. Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the Mixed Lymphocyte Reaction. J Neuroimmune Pharmacol. 2013. 8:1239-   1250. PMID: 23824763
  135. Robinson, R.H., J.J. Meissler, X, Fan, D. Yu, M.W. Adler, T.K. Eisenstein. 2015. A CB2-selective cannabinoid suppresses T-cell activities and increases Tregs and IL-10. J     Neuroimmune Pharmacol. DOI 10.1007/s11481-015-9611-3
  136. Eisenstein, T.K., J.J. Meissler. 2015. Effects of cannabinoids on T-cell function and resistance      to infection. 2015. J Neuroimmune Pharmacol. DOI 10.1007/s11481-015-9603-3

 

Toby K. Eisenstein

Professor

 

  • : 215-707-3585
  • : 215-707-6661
  • DEPARTMENTDepartment of Microbiology and Immunology
    Temple University School of Medicine
  • COUNTRYPennsylvania