- : (813) 974-5419
- DEPARTMENTDepartment of Internal Medicine
University of South Florida
- COUNTRY USA
The goal of the proposed research is to elucidate the protective role of Alda-1 (a known activator of ALDH2 activity) in chlorine-induced murine model of lung injury using WT and ALDH2*2 mice.
I completed my doctoral thesis entitled “oxidative stress in the production of aflatoxin and its precursor intermediate biosynthesis” and specialized as a free radical biochemist with a concentration in lung injury at Oklahoma State University. I expanded my research skills at Harvard under the supervision of Dr. Aaron B. Waxman and Dr. Charles A. Hales, and I have focused on understanding the mechanisms of oxidative stress in hyperoxia, as seen in our many published findings in several high-impact peer-reviewed journals, including The Journal of Immunology, American Journal of Physiology - Lung Cellular and Molecular Physiology and American Journal of Respiratory Cellular Molecular Biology. Currently, our laboratory is working on lung injury in the context of oxygen toxicity. Recently, we have expanded our work to the role of ALDH2 in chlorine-induced acute lung injury, which has never been studied. Our exciting preliminary data shows that chlorine exposure significantly suppresses ALDH2 activity in wild type (WT) mice. In addition, ALDH2 knockout (ALDH2-/-) and ALDH2 knock in (ALDH2*2) mice showed significantly increased mortality when exposed to Cl2 compared to controls. Our preliminary data also shows that ALDH2 activator Alda-1 restored ALDH2 activity in human small airway epithelial cells (hSAEC) exposed to Cl2. I consider studying the therapeutic effect of Alda-1 in chlorine-induced lung injury in mice as the next logical step, which is the highlight of this application. I have demonstrated a solid record of successful and productive research projects in acute lung injury at the Massachusetts General Hospital, Harvard Medical School, and the University of South Florida, and I have full confidence that my relevant experience and understanding has prepared me to lead the proposed project.