Anna Maria Geretti
- : 44 (0)151 795 9625
- DEPARTMENTDepartment of Virology & Infectious Diseases
Institute of Infection & Global Health
University of Liverpool
My research work, primarily for translation of basic science into applications within care settings, focuses on five major related themes within a large network of collaborators based in Europe, North America and Africa:
Antiretroviral therapy. I study responses to HIV therapy, with a focus on virological determinants of treatment outcomes including drug resistance, and in the context of both observation analyses and clinical trials. Closer to the bench, I study the mechanisms of HIV persistence during therapy and the interplay between the virus and host immunity.
HIV genetic variability. I use sequencing techniques (including next generation platforms) and bioinformatics to investigate the molecular epidemiology of HIV transmission, including the identification of novel virus strains.
Hepatitis B virus (HBV) and hepatitis C virus (HCV). I study the clinical and virological expression of HBV and HCV infection, including HIV influence on virus genetic evolution and antiviral drug resistance. Much of the HBV work takes place in Africa and capacity building is a major outcome of these activities.
Use of vaccines in the context of immunocompromise. I have a clinical interest in optimising the use of vaccines and other forms of immune prophylaxis in subjects with HIV and other forms of immunocompromise. I chair the British HIV Association (BHIVA) Immunisation Guidelines Panel, which is responsible for the formulation of national recommendations on vaccination in adult people with HIV. The first edition was published in 2008 and I am currently chairing its revision.
Molecular diagnostics for viral infections.This work addresses the development & evaluation of platforms and assays for detection &characterisation of viral infections.