Basic research into analysis of causal variants responsible for human autoimmune diseases such as Ankylosing Spondylitis
Basic Immunology research of interactions between the innate and adaptive immune systems Basic Research into several aspects of Gene transfer based therapy, both virus-mediated, and non-virus mediated.
T1 research translating laboratory findings into the clinical realm, primarily in regard to immunomodulatory strategies to treat various forms of cancer, as well infectious and inherited or acquired diseases.
Research into basic physiology of Duchenne Muscular Dystrophy/Glycogen storage disease Type II/Pompe disease/musculoskeletal disorders, with a goal towards T1 research.
Clinical enzyme replacement trials and therapy in Infantile GSD-II/Pompe disease, and other lysosomal storage diseases
Applied Gene therapy in several human diseases.
Use of gene transfer to treat cancers, to augment anti-cancer immunity.
Genetic Vaccine development for use in infectious diseases.
Use of animal models of human disease to predict clinical outcomes of potential therapies.
Understanding innate and adaptive immune responses to gene transfer
Clinical Dysmorphology and syndrome classification/identification
Pre-emptive clinical strategies for patients affected by any variety of genetic diseases.
DEPARTMENTDepartment of Microbiology and Molecular Genetics
College of Osteopathic Medicine
Michigan State University