Publications

  1. Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A. Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1. PLoS One. 2015;10(7):e0131201.
  2. Neofytou E, Deuse T, Beygui RE, Schrepfer S. Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties. Transplantation 2015;99(6):1113-8.
  3. Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S. Immunobiology of fibrin-based engineered heart tissue. Stem Cells Transl Med. 2015;4(6):625-31.
  4. Schmidt-Lucke C, Zobel T, Schrepfer S, Kuhl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschope C. Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy. J Infect Dis. 2015. pii: jiv178.
  5. Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Gruenewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell 2015;16(1):33-8.
  6. Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nagakami F, Heymann HM, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten
  7. A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 2014;5:5214.
  8. Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolanos JP, Rakovic A, Spin J, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S. DCA prevents restenosis in preclinical animal models of vessel injury. Nature 2014;509(7502):641-4.
  9. Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S. Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models. J Vis Exp. 2014;14(87).
  10. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. The Ca(2+)-Activated K(+) Channel KCa3.1 as a Potential New Target for the Prevention of Allograft Vasculopathy. PLoS One. 2013;8(11):e81006.
  11. Vrtovec B, Haddad F, Pham M, Deuse T, Fearon WF, Schrepfer S, Leon S, Vu T, Valantine H, Hunt SA. Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients. Transplant Proc. 2013;45(6):2406-9.
  12. Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schroeder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S. Immunological properties of extraembryonic human Mesenchymal Stromal Cells derived from gestational tissue. Stem Cells Dev. 2013;22(19):2619-29.
  13. Jungraithmayr W, Jang JH, Schrepfer S, Inci I, Weder W. Small Animal Models of Experimental Obliterative Bronchiolitis. Am J Respir Cell Mol Biol. 2013;48(6):675-84.
  14. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, MiuraH, LängerF, Reichenspurner H, Robbins RC, Schrepfer S. The potassium channel KCa3.1 as new therapeutic target for preventing obliterative airway disease after lung transplant. Transplantation 2013;95(2):285-292.
  15. Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. Effects of Intracoronary CD34+ Stem Cell Transplantation in Nonischemic Dilated Cardiomyopathy Patients: 5-Year Follow-Up. Circ Res. 2013;112(1):165-73.
  16. Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S. Significant reduction of acute cardiac allograft rejection by selective JAK1/3-inhibition using R507 and R545. Transplantation 2012;94(7):695-702.
  17. Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S. Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis. J Vis Exp. 2012;(63):e3663.
  18. Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans SM, Carrier L, Eschenhagen T. Localization of islet-1-positive cells in the healthy and infarcted adult murine heart. Circ Res. 2012;110(10):1303-10.
  19. Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. HLA I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. Circulation 2011;124(11 Suppl):S3-9.
  20. Duske H, Sputtek A, Binder T, Kröger N, Schrepfer S, Eiermann T. Assessment of physiologic natural killer cell cytotoxicity in vitro. Hum Immunol. 2011;72(11):1007-12.
  21. Deuse T, Seifert M, Tyan D, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunobiology of naïve and gene-tically-modified HLA I knockdown human embryonic stem cells. J Cell Science 2011;124:1-9.
  22. Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M. Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo. PLoS One. 2011;6(8):e23101.
  23. Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins R C, Eschenhagen T, Schrepfer S. Bioluminescence Imaging for Assessment of Immune Responses Following Implantation of Engineered Heart Tissue (EHT). J Vis Exp. 2011;(52).
  24. Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP. Prevention of transplant coronary artery disease by prenylation inhibitors. J Heart Lung Transplant. 2011;30(7):761-9.
  25. Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant. 2011;20(5):655-67.
  26. Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S. Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy. J Vis Exp. 2010;(46).
  27. Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting. Circulation. 2010;122(11 Suppl):S170-8.
  28. Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. Non-volume-loaded heart provides a more relevant heterotopic transplantation model. Transpl Immunol. 2010;23(1-2):65-70.
  29. Hoffmann J, Glassford AJ, Doyle TC, Robbins RC, Schrepfer S, Pelletier MP. Angiogenic effects despite limited cell survival of bone marrow-derived mesenchymal stem cells under ischemia. Thorac Cardiovasc Surg. 2010;58(3):136-42.
  30. Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. J Vis Exp. 2010;(35).
  31. Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. LAD-ligation: a murine model of myocardial infarction. J Vis Exp. 2009;(32).
  32. Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S. Mechanisms behind Local Immunosuppression Using Inhaled Tacrolimus in Preclinical Models of Lung Transplantation. Am J Respir Cell Mol Biol. 2010;43(4):403-12.
  33. Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC. Poor Functional Recovery After Transplantation of Diabetic Bone Marrow Stem Cells in Ischemic Myocardium. J Heart Lung Transplant. 2009;28(11):1158-1165.e1.
  34. Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation. 2009;120(11 Suppl):S247-54.
  35. Deuse T, Ikeno F, Robbins RC, Schrepfer S. Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model. J Vis Exp. 2009;(31).
  36. Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection. Transplantation. 2009;87(5):653-9.
  37. van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC. Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation. 2009;87(5):642-52.
  38. van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC. Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation. 2008;118(14 Suppl):S121-9.
  39. Schrepfer S, Swijnenburg RJ, Govaert J, Cao F, Ransohoff K, Sheikh A, Haddad M, Connolly A, Davis M, Robbins RC, Wu J. Immunosupressive therapy mitigates immunological rejection of human embryonic stem cell xenographs. Proc Natl Acad Sci U S A. 2008;105(35):12991-6.
  40. Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu J. In Vivo Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Rejection Following Transplantation. Stem Cells Dev. 2008;17(6):1023-9.
  41. Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S. Novel Immunosuppression: R348, a JAK3- and Syk-inhibitor, attenuates acute cardiac allograft rejection. Transplantation. 2008;85(6):885-92.
  42. Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S.Prevention and Inhibition but not Reversion of Chronic Allograft Vasculopathy by FK778. Transplantation. 2008;85(6):870-7.
  43. Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Bergow C, Pelletier MP, Robbins RC, Schrepfer S. Introducing the first polymer-free leflunomide eluting stent. Atherosclerosis 2008;200(1):126-34.
  44. Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A. Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Artif Cells Blood Substit Immobil Biotechnol. 2008;36(1):34-44.
  45. Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008l;22(7):2561-8.
  46. Sheikh AY, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier MP. Right atrial mass after primary repair of an atrial septal defect: thrombus masquerading as a myxoma. Ann Thorac Surg. 2007;84(5):1742-4.
  47. Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fischbein MP, Robbins RC, Pelletier MP. Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease. Am J Transplant. 2007;7:1733–1742.
  48. Schrepfer S, Deuse T, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP. Techniques for experimental heterotopic and orthotopic tracheal transplantations – When to use which model? Transpl Immunol. 2007;17(4):255-261.
  49. Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP. Stem cell transplantation: The lung barrier. Transplant Proc. 2007;39(2):573-6.
  50. Schrepfer S, Deuse T, Pelletier MP, Fischbein MP, Robbins RC, Reichenspurner H. Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection? Transplant Proc. 2007;39(2):569-72.
  51. Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP. Simplyfied protocol to isolate, purify, and culture expand mesenchymal stem cells. Stem Cell Dev 2007;16(1):105-7.
  52. Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP. Experimental orthotopic tracheal transplantation: The Stanford technique. Microsurgery. 2007;27(3):187-9.
  53. Sydow K, Schrepfer S, Franzen O, Detter C, Willems S, Meinertz T, Reichenspurner H. Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary fibroelastomas in a young male adult. J Thorac Cardiovasc Surg. 2007;133(2):564-5.
  54. Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H. FK778 in experimental xenotransplantation – A detailed analysis of drug efficacy. J Heart Lung Transplant. 2007;26(1):70-7.
  55. Schrepfer S, Deuse T, SultanK, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H. Restenosis development after mechanical injury: A new field of application for Malononitrilamides? Cardiology. 2006;108(2):128-137.
  56. Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H. The selective estrogen receptor- agonist biochanin A shows vasculoprotective effects without uterotrophic activity. Menopause. 2006;13(3):489-99.
  57. Schrepfer S, Deuse T, Sydow K, Schafer H, Detter C, Reichenspurner H. Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium. Transplant Proc. 2006;38(3):741-4.
  58. Schrepfer S, Deuse T, Koch-Nolte F, Detter C, Reichenspurner H.FK778: New Cellular and Molecular Mechanisms of Action. Transplant Proc. 2006;38(3):757-61.
  59. Baldus S, RudolphV, Roiss M, Ito W, Rudolph T, Eiserich JP, Sydow K, Kubala L, Berglund L, Schrepfer S, Deuse T, Risius T, Klemm H, Reichenspurner H, Meinertz T, Heitzer T. Heparin increases endothelial nitric oxide bioavailability by mobilizing vessel-adherent myeloperoxidase. Circulation 2006;113(15):1871-8.
  60. Schrepfer S, Deuse T, Koch-Nolte F, Haddad M, Schwedhelm E, Böger E, Schäfer H, Detter C, Reichenspurner H. Sirolimus and FK778: Two antiproliferative Immunosuppressants with same efficiency but different mechanisms of action in a rat tracheal transplant model. Transpl Int. 2006;19(4):310-8.
  61. Schrepfer S, Deuse T, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Reichenspurner H. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. J Heart Lung Transplant 2005; 24(11):1844-54.
  62. Schrepfer S, Deuse T, Schafer H, Koch-Nolte F, Braendle W, Reichenspurner H. The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system. Transpl Immunol. 2005;15(1):45-53.
  63. Schrepfer S, Deuse T, Schafer H, Reichenspurner H. FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival. Transpl Int. 2005;18:215-20.
  64. Schrepfer S, Deuse T, Reichenspurner H. The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose-dependent. Transplantation. 2004;77:509-13.
  65. Schrepfer S, Deuse T, Koch-Nolte F, Schäfer H, Böger R, Reichenspurner H. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation 2004;78:71-77.
  66. Schrepfer S, Deuse T, Reichenspurner H. New technique for chest opening in mice: U-sternotomy. Microsurgery. 2003;23:274-5.
  67. Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm D, Willems S, Lacour-Gayet F, Reichenspurner H. Successful resection of a symptomatic right ventricular lipoma. Ann Thorac Surg. 2003;76:1305-7.
  68. Deuse T, Schrepfer S, Reichenspurner H. Immunosuppression with FK778 and Mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003;76:1627-9.
  69. Deuse T, Lange V, Schrepfer S, Eigenthaler M, Walter U, Elert O. Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat. Eur Surg Res. 2003;35:6-13.
  70. Gulbins H, Schrepfer S, Uhlig A, Goldemund A, Oberhoffer M, Reichenspurner H, Meiser B, Reichart B. Myoblasts survive intracardiac transfer and divide further after transplantation. Heart Surg Forum 2002;5:340-4.
  71. Gulbins H, Anderson I, Kilian E, Schrepfer S, Uhlig A, Kreuzer E, Reichart B. Five years of experience with mitral valve homografts. Thorac Cardiovasc Surg 2002;50:223-9.

 

 

 

 

 

 

 

 

Sonja Schrepfer

Professor

 

 

  • : 415-502-8742    
    • DEPARTMENT University Heart Center Hamburg
      Transplant and
      Stem Cell Immunobiology Lab
    • COUNTRY USA