Publications

Invited Addresses

• “Constitutive Models for Powders”, Laboratoire Sols, Solides, Structures, UJF/CNRS/INPG, Grenoble, France, December 17, 1992.
• “A Biomimetic Approach to Materials Design”, Keynote address at the Annual Meeting of the American Society of Biomechanics, Iowa City, Iowa, October 22, 1993.
• “Biomaterial Strategies for Bone Repair”, ABC Traveling Fellows Lecture, Orthopaedic Surgery Department, Children’s Hospital, Boston, MA, May 17, 1996.
• “Biomimetic Ceramic Processing”, Solid State NMR Group Meeting, Biomaterials Laboratory, Massachusetts General Hospital, Boston, MA, October 21, 1996.
• “Native Bone Crystals for Bone Repair Applications”, Batelle Pacific Northwest National Laboratory, Richland, WA, November 10, 1997.
• “Native Bone Crystals for Bone Repair Applications”, Grice Lecture, Harvard Medical School, Boston, MA, October, 1997.
• “Achieving tissue attachment through enhanced, selective tissue regeneration”, Roundtable on Biomedical Engineering Materials and Applications, National Research Council, National Academies of Science, Woods Hole, MA, July 17, 2008.
• “The Role Of Calcium Phosphate Biomaterial Delivery Systems In Regenerative Engineering And Anti-Cancer Therapies”, Southwest Research Institute, San Antonio Texas. August 21, 2009.
• “Use of GFP lineage reporter progenitor cells to assess osteoblast differentiation on biomaterials”, Orthopaedic Research Seminar Series, Children’s Hospital, Boston, MA, June 5, 2009.
• “Nanoparticles Of Calcium Phosphate And Cisplatin For Targeted Delivery To Head And Neck Cancer”. Yale Cancer Center, Otolaryngology Dept. New Haven, CT. December 11, 2009.
• “Use of osteoblast lineage reporter cells for visualizing in vitro osteogenesis on various biomaterials”, Northeast Biomaterials Day, Columbia University, New York, NY. March 27, 2010.
• “Multiple Growth Factor Delivery Strategies for Musculoskeletal Repair”, Harvard-MIT Division of Health Sciences and Technology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. August 24, 2010.
• “Mouse Calvarial Bone Defect Healing by Human Embryonic Stem Cells”, Department of Biology, Morehouse College, Atlanta, GA. October 4, 2011.
• "Who done it?" - assessing in vitro osteoblast differentiation on biomaterials using Col1a1 reporter cells”, Biomaterials Institute, Syracuse University, April 27, 2012.
• “Monitoring osteogenic differentiation using Co1a1 reporter cells”, French National Institute of Health and Medical Research Laboratory (INSERM) Unit 1109, Université de Strasbourg, France, May 25, 2012.
• “New biological tools for determining progenitor cell differentiation to functional osteoblasts” Universite de Bordeaux Segalen, Bordeaux, France, March 25, 2013
• “New biological tools for determining progenitor cell differentiation to functional osteoblasts” French National Center for Scientific Research (CNRS) Toulouse, France, March 26, 2013.
• “In vivo bone regeneration with mesenchymal-like progenitors from human embryonic stem cells”, Department of Biomedicine, Institute for Surgical Research and Hospital management, University Hospital, Basel, Switzerland, on June 13, 2013.
• “Recapitulation of developmental bone tissue generation by MSCs derived from human embryonic stem cells”, MSC 2013, National Center for Regenerative Medicine, Case Western Reserve University (CWRU) Cleveland, OH on August 19, 2013.
• “Identifying Osteoinductive Biomaterials with Progenitor Cells from Collagen/GFP Reporter Transgenic Mice” Biomedical Engineering Department at Worcester Polytechnic Institute, Worcester, MA on Oct 16, 2013.
• “Collagen Type I Reporter Mice: A Tool For Determining Progenitor Cell Differentiation To Functional Osteoblasts” TERMIS-Americas 2013 Annual Conference and Exposition, Atlanta Georgia, on November 12, 2013.

Conference Presentations – Oral

• “Modelling Powder Consolidation”, LT Kuhn, RM McMeeking and FF Lange. International Conference on Micromechanics of Granular Media, Clermont-Ferrand, France. 1989.
• “Constitutive Models for the Deformation of Powder Compacts”, LT Kuhn, J Xu and RM McMeeking. ASM-TMS Materials Week in Chicago, IL, 1992.
• “The Effect of Organic Macromolecules on the Vaterite to Calcite Transformation”, L Kuhn Spearing, S Sarig, DJ Fink and AH Heuer. Spring Meeting of the Materials Research Society, Pittsburgh, PA. 1994
• “Fracture Mechanisms of the Strombus Gigas Pink Conch Shell: Implications for the Design of Multilayer Composite Materials”, L Kuhn and AH Heuer. Annual Meeting of The American Ceramic Society, Indianapolis, Indiana, April 25, 1994.
• “Fracture of the Strombus Gigas Conch Shell”, L Kuhn and A Heuer. Fall Meeting of the Materials Research Society, Boston, MA, November 29, 1994.
• “Powder Processing of Bone Mineral”, L Kuhn and MJ Glimcher. Fall Meeting of the American Ceramic Society, New Orleans, LO, November 6, 1995.
• “Carbonated Apatite Nanocrystals From Bone”, L Kuhn, C Rey, and MJ Glimcher. The Mineral, Metals and Materials Society Annual Meeting. 1996.
• “Characterization of the Apatite Crystals of Bone and Their Maturation in Osteoblast Cell Culture”, L Kuhn, L Gerstenfeld, C Rey, MJ Glimcher.  Gordon Research Conference on Biomineralization, Plymouth, NH, August 5, 1996.
• “Dissociation of the Biomineralization Process from Collagen Deposition in Specific Osteosarcoma Cell line Cultures”, L Kuhn, L Gerstenfeld, W Landis, M Grynpas, MJ Glimcher. 6th Int. Conf. of the Chemistry and Biology of Mineralized Tissues, Vittel, France, November 1998.
• “Development Of A Murine Calvarial Model To Study Implant Guided Bone Growth”, M Freilich, P Schleier, L Kuhn, D Shafer, P Hortschansky, M Wei. 30th Annual Meeting and Exposition of the Society For Biomaterials, in Memphis, Tennessee, April 2005.
• “Intralesional Calcium Phosphate/Cisplatin Therapy of Solid Tumors”, L Kuhn. 30th Annual Meeting and Exposition of the Society For Biomaterials, April 27 – 30, 2005 in Memphis, Tennessee, USA.
• “Fluorescent Quantification of Osteogenesis using GFP Transgenic Mouse Reporter Cell Technology”, L Kuhn, AJ Goldberg, Y Liu, L. Wang, D. Rowe.  Hilton Head Workshop on Regenerative Medicine, Hilton Head, NC, March 5, 2009.
• “Fluorescent Quantification of Osteogenesis of GFP-transgenic Mouse Calvarial Osteoblasts on Biomimetic Coatings”, Y Liu, M Advincula, Y Wang, P Maye, AJ Goldberg and LT Kuhn. Society For Biomaterials annual meeting, San Antonio, TX, April 22, 2009.
• “Evaluating Controlled Sequential Delivery of Two Growth Factors To Enhance Osteoinduction In Young Mice”, Q Wang, G Ou, B Kelm, G Gronowicz, M Hurley, L Kuhn. Society For Biomaterials Annual Meeting and Exposition, April 21 - 24, 2010 in Seattle, Washington, USA.
• “An Overview of Multi-Factor Drug Delivery for Musculoskeletal Regeneration”, L Kuhn.  Lead Symposium speaker.  Society For Biomaterials Annual Meeting and Exposition, April 21 - 24, 2010 in Seattle, Washington, USA.
• “Substantial Mouse Calvarial Bone Defect Healing by Human Embryonic Stem Cells”, LT Kuhn,  Y Liu, NL Boyd, J Dennis, H Aguila, A Lichtler, AJ Goldberg. Orthopaedic Research Society 2011 Annual Meeting in Long Beach, California, January 13-16, 2011.
• “Substantial Mouse Bone Repair by Osteo-chondrogenic Progenitors Derived From hESCs”, Y Liu; NL Boyd; JE Dennis; AJ Goldberg; SL Stice; LT Kuhn.15th Annual Hilton Head Workshop, Hilton Head, SC, March 16 -19, 2011.
• “Substantial mouse calvarial bone defect healing by human embryonic stem cells.” LT Kuhn, Y Liu, N Boyd, J Dennis, HL. Aguila, A.J. Goldberg. StemCONN 2011, Farmington, CT. March 22, 2011.
• “Modified Hyaluronic Acid Hydrogel for Maintaining Human Induced Pluripotent Stem Cells” Y Liu, AJ Goldberg and LT Kuhn. Society For Biomaterials 2011 Annual Meeting in Orlando, FL, April 13-16, 2011.
• “Release of multiple growth factors for stimulating endogenous progenitor cells in aging bone” Liisa T. Kuhn,Guomin Ou, Marja Hurley, and Gloria Gronowicz. 9th World Biomaterials Congress, Chengdu, China, June 2-7, 2012.

Conference Presentations – posters (unpublished abstracts)

• Colloidal Apatite for Local Delivery of Cisplatin to Osteosarcomas.  LT Kuhn, A Barroug, LC Gerstenfeld, MJ Glimcher, Poster, 6th World Biomaterials Congress, Society for Biomaterials, Hawaii, 2000.
• Pharmacokinetic Comparison of Intravenous, Intratumoral and Controlled Release Intratumoral ETEX/Cis Treatment.  PJ Hoopes, L Bartholomew, R Strawbridge, S Weinstein, L Lewis, E Demidenko, S Bryant, M Aiolova, E Boyer, L Kuhn, G Crabtree, D Lee, American Association of Cancer Research (AACR) Annual Meeting, March 2001.
• Comparison of Intravenous and Controlled Release of ETEX/Cis Treatment in a Murine Tumor.  PJ Hoopes, L Bartholomew, R Strawbridge, S Weinstein, L Lewis, E Demidenko, S Bryant, M Aiolova, E Boyer, L Kuhn, G Crabtree, D Lee, American Association of Cancer Research (AACR) Annual Meeting, March 2001.
• The Effect of the Biochemical Nature of Two Novel Adjuvants on Immune Response, LF Cimino, R Yadav, AT Vella, LT Kuhn.  BEACON Symposium and Technology Fair, Hartford, CT. October 2004.
• Efficacy of a Novel Chemotherapeutic Drug Delivery System, AL Deliso, J Bordonaro, LT Kuhn.  BEACON Symposium and Technology Fair, Hartford, CT. October 2004. 
• Chemoradiotherapy Of ME-180 Tumors With An Intratumoral Cisplatin/Calcium Phosphate Drug Delivery System.  F Santiago, S Campbell, R Dowsett, and L Kuhn, Poster presentation.  BEACON Symposium and Technology Fair, Hartford, CT October, 2005.
• Synthesis And Characterization Of Nanoparticulate CaP/Cisplatin For Lymphatic Targeted Drug Delivery.  X Cheng and LT Kuhn. Poster presentation at the 3rd International Nanomedicine and Drug Delivery Symposium, Baltimore, MD, Sept. 26-27, 2005.  Student awarded travel award.
• Chemoradiotherapy of ME-180 Tumors with an Intratumoral Cisplatin/Calcium Phosphate Drug Delivery System.  F Santiago, S Campbell, R Dowsett, and L Kuhn. Proceedings of the IEEE 32nd Northeast Bioengineering Conference, April 1, 2006, pp189-190.
• Chemoradiotherapy of ME-180 Tumors with an Intratumoral Cisplatin/Calcium Phosphate Drug Delivery System.  F Santiago, S Campbell, R Dowsett, and L Kuhn. American Association of Pharmaceutical Scientists Northeast Regional Discussion Group, 9th Annual Meeting, Rocky Hill, CT, April 28, 2006.
• Effect Of Nano-Sizing Calcium Phosphate/Cisplatin Coordination Complexes On In Vitro Drug Release.  L Kuhn and X Cheng. Poster presentation at Particles 2006 conference:  Medical/Biochemical Diagnostic, Pharmaceutical, and Drug Delivery Applications of Particle Technology, Orlando, FL, May 13-16 2006.
• Sulfonic Acid-Functionalized Mesoporous Silica Particles as Carriers for the Local Delivery of the Anticancer Agent Doxorubicin, IL Lagadic, R Shah, L Kuhn and X Cheng. 34th American Chemical Society Northeast Regional Meeting (NERM 2006), Binghamton, NY, October 5-7, 2006.
• Polymer and Polymer-Ceramic Scaffolds for Guiding Bone Growth Around Dental Implants.  L Kuhn, M Freilich, D Shafer, D Adams, and B Wen. Poster presentation, State of Connecticut Stem Cell meeting, StemConn07, Hartford, CT, March 28, 2007.
• Particulates of Calcium Phosphate/Cisplatin Overcome Drug Resistance of A2780cis Cells.  L Kuhn and X Cheng. Poster presentation, Society for Biomaterials Annual Meeting, Chicago, IL, April 18-21, 2007.
• Inhibition of Lymphatic Metastasis Using Lymph Node Targeted Calcium Phosphate/Cisplatin Nanoparticles. PL Piteo, B Wen, and LT Kuhn, 11th Annual American Association of Pharmaceutical Scientists (AAPS) Northeast Regional Discussion Group, Rocky Hill, CT, April 25, 2008.
• Detection of Micrometastases in Lymph Nodes. MJ Romeo, B Bird, L Kuhn, E Natarajan, M Diem. SPEC2008 conference held at the congress center of the Technological Park of Universidade do Vale do Paraíba, São José dos Campos, São Paulo, Brazil. Oct 25-29, 2008.
• A New Technology: Dental Implant Guided Bone Growth. B Wen, L Kuhn, M Dard, M Obrecht, M Stauber, K Jorgenson, D Shafer, and M Freilich. Center for Integration of Medicine and Innovative Technology Congress, Boston, MA, October 2008.
• Implant guided vertical bone growth in the mini-pig. L Kuhn, D Shafer, B Wen, P Schleier, D Pendrys, O Marcel, M Dard, M Freilich. AO Foundation Congress. Davos, Switzerland, March 2010.
• Fibrillar Collagen Thin Films Promote Early Osteogenesis. L Liu, A Goldberg, P Maye, M Advincula, L Kuhn. Annual meeting of the American Association of Dental Research. Washington, DC, March 5, 2010.
• Variance of Extracel Hydrogel Compositions and the Osteogenic Effects on GFP-reporter Preosteoblasts. Y Liu, AJ Goldberg, LT Kuhn. Society For Biomaterials 2009 Annual Meeting and Exposition, April 21 - 24, 2010 in Seattle, Washington, USA.
• Osteogenesis by hESCs After Cell Culture On Fibrillar Type I Collagen Coatings. Y Liu, AJ Goldberg, JT Elliott, AL Plant and LT Kuhn. Engineering Stem Cell Fate, Society for Biological Engineers, Boston, MA, May 2-5, 2010.
• Non-Physiological Mineral Deposition in vitro by hESC-Derived and Primary Human Osteoblasts Under Standard Osteogenic Conditions. L Charles, J Woodman, AJ Goldberg, G Gronowicz and LT Kuhn. Engineering Stem Cell Fate, Society for Biological Engineers, Boston, MA, May 2-5, 2010.
• A Novel Feeder-Free Pluripotent Stem Cell Culture Substrate That Supports Mouse Embryonic And Human Induced Pluripotent Stem Cell Growth And Proliferation. K Johnson, Y Liu, R Wesselschmidt, LT Kuhn, M Wight, A McCollough, TI Zarembinski, SK Atzet. ISSCR 8th Annual Meeting, in San Francisco, CA, USA, June 16 - 19, 2010.
• PLA and PLA-Ionomeric Thin Films Influence Osteoblast Cell Differentiation C. T. Gomillion1, R. K. Lakhman, R. M. Kasi, R. A. Weiss, L.T. Kuhn, A. J. Goldberg. Biomedical Engineering Society, Hartford, CT, October 13, 2011.
• The Effects of Collagen Thin Films upon Osteogenic Differentiation Illuminated by pOBCol2.3GFP Cells, T.L. Estus, A.J. Goldberg, and L.T. Kuhn, Biomedical Engineering Society, Hartford, CT, October 13, 2011.
• Synthetic Hydrogels for a Feeder-Free Approach to Stem Cell Expansion, L. F. Charles, S. K. Atzet, T. I. Zarembinski, and L. T. Kuhn. Biomedical Engineering Society, Hartford, CT, October 13, 2011.
• Exported 18-kDa Isoform of Fibroblast Growth Factor-2 Improved Bone Regeneration in Critical Size Mice Calvarial Defects, D Ueno, L Xiao, LT Kuhn, MM. Hurley, American Society of Bone and Mineral Research, San Diego, California, USA. September 16-20, 2011.
• Release of multiple growth factors for stimulating endogenous progenitor cells in bone in elderly patients. LT Kuhn, Guomin Ou, Marja Hurley, and Gloria Gronowicz, French Society of the Biology of Mineralized Tissues,JFBTM14, Bordeaux, France, May 29-31 2012.
• Sodium Citrate Stabilized Calcium Phosphate Nanoparticles for the Sustained Delivery of Cisplatin E. Jacobs, J. Woodman, L. Kuhn. Annual Meeting of the Society For Biomaterials, Boston, MA, April 2013.
• Novel Stabilization of Calcium Phosphate Nanoparticles for Drug Delivery. J Woodman, G Prestwich, D Burgess, and L Kuhn, Annual Meeting of the Society For Biomaterials, Denver, CO, April 2014.
• 3-D PEM Coatings to Deliver FGF-2 and Promote In vitro and In vivo Osteoprogenitor Cell Proliferation. E. Jacobs, L. Zhu, J. Woodman, L. Charles, M. Hurley, G. Gronowicz, L.T. Kuhn, Annual Meeting of the Society For Biomaterials, Denver, CO, April 2014.

Published Conference Papers and Abstracts

• LT Kuhn, RM McMeeking and FF Lange, Modelling Powder Consolidation, in Powders and Grains, Proceedings of the International Conference on Micromechanics of Granular Media (ed. J Biarez and P Gourves), Clermont-Ferrand, France, 1989, AA Balkema, pp. 331-338.
• LT Kuhn, J Xu and RM McMeeking, Constitutive Models for the Deformation of Powder Compacts in Computational and Numerical Techniques in Powder Metallurgy, Symposium Proceedings from the ASM-TMS Materials Week in Chicago, Eds. D. Maden, I. Anderson, W. Fraser, P. Kumar and M. McKimpson, 1992.
• DJ Fink, LT Kuhn, AI Caplan and AH Heuer, Eggshell Assembly - A Model for Biomimetic Ceramic Production in Quality of Poultry Products, Proceedings of 5th European Symposium on the Quality of Eggs and Egg Products, Tours, France, pp. A1-A6, 1993.
• L Kuhn Spearing, S Sarig, DJ Fink and AH Heuer, The Effect of Organic Macromolecules on the Vaterite to Calcite Transformation, in S: Biomolecular Materials by Design, Eds. H. Bayley, D. Kaplan, and M. Navia, (Mat. Res. Soc. Proc., Pittsburgh, PA) Vol.330, pp. 127-132, 1994.
• L Kuhn-Spearing, C Rey, H-M Kim and MJ Glimcher, Carbonated Apatite Nanocrystals From Bone in Synthesis and Processing of Nanocrystalline Powder, Ed. D Bourell (The Mineral, Metals and Materials Society, Pennsylvania), p. 57-68, (1996).
• D Lee, A Tofighi, L Kuhn, C Rey. Calcium Phosphate: Carrier for Therapeutic Agents, in Proceedings of CIMTEC 2002, 3rd Forum on New Materials- Part VI, 6th Int. Conference, “Materials in Clinical Applications”, Ed. P. Vincenzini, R. Barbucci, Techna Srl, Faenza, Italy, pp. 123-130, (2003).
• MA Freilich, M Wei, S Iddir, LT Kuhn, and DM Shafer. "Improvement of Alveolar Bone Height Using Novel Graft Placement", Proceedings of Bioceramics 17 Conference, Key Eng. Mater. 284-286, and 889-892 (2005).
• F Santiago, S Campbell, R Dowsett, and L Kuhn. Chemoradiotherapy of ME-180 Tumors with an Intratumoral Cisplatin/Calcium Phosphate Drug Delivery System, Proceedings of the IEEE 32nd Northeast Bioengineering Conference, pp189-190, (2006).
• AD Rosenberg, LT Kuhn L Gilles de Pelichy, J Jolette. Osteoinductive Composites Of Calcium Phosphate Cement And Demineralized Bone Matrix, Poster presentation, Transactions of the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, Vol.32, poster 1429 (2007).
• P Piteo, B Wen, L Kuhn. Evaluation of Lymphatic Metastasis Using Calcium Phosphate/Cisplatin Nanoconjugates, Proceedings of the IEEE 36th Northeast Bioengineering Conference, Providence, RI. (2008). http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=04967692
• L Kuhn, B Wen, M Obrecht, M Stauber, K Jorgenson, D Shafer, and M Freilich. Quantitative Evaluation of Supracrestal Bone Growth Around Dental Implants. M. Dard, IADR meeting Toronto, Canada. J Dent Res 87 (Spec Iss B): Abstract 108779, (2008).
• L Kuhn, B Wen, P Piteo. Reduction of chemotherapy side effects and targeted inhibition of lymph node metastasis with a calcium phosphate nanoparticle delivery vehicle, 31st Annual San Antonio Breast Cancer Symposium, San Antonio, TX, Dec 10-14, 2008. Published as a supplement in Cancer Research 69:2 (2009). www.posters2view.com/sabcs08/viewp.php?nu=2135
• LT Kuhn, MC Advincula, Y Liu, G Gronowicz, P Habibovic, and AJ Goldberg. Biomimetic method for coating tissue culture polystyrene with carbonated hydroxyapatite. J. Dent. Res. 88: IADR Abstract 2614, (2009).
• L Charles, J Woodman, AJ Goldberg, G Gronowicz and LT Kuhn. Non-Physiological Mineral Deposition in Vitro by hESC-Derived and Primary Human Osteoblasts Under Standard Osteogenic Conditions, Proceedings of the IEEE 36th Northeast Bioengineering Conference, Mar 26-28, 2010.
• Y Liu, AJ Goldberg, JT Elliott, AL Plant and LT Kuhn. Osteogenesis by hESCs After Cell Culture On Fibrillar Type I Collagen Coatings, Proceedings of the IEEE 36th Northeast Bioengineering Conference, Mar 26-28, 2010.
• R. Lakhman, K. O’Brien, R. Kasi, R.A. Weiss, L.T. Kuhn, M. Mina and A.J. Goldberg Varying PLA functionality and texture to influence osteoprogenitors. Academy of Dental Materials, Trieste, Italy, October 2010
• R Lakhman, K O’Brien, R Kasi, RA Weiss, LT Kuhn and AJ Goldberg. Visual Monitoring of Osteoblast Progenitor Cell Differentiation on Dewetted PLA Thin Films. Materials Research Society, San Francisco, CA, April 2011.

Peer Reviewed Publications, * = Kuhn is communicating author

1. LT Kuhn, RM McMeeking and FF Lange. A Model for Powder Consolidation, Journal of the American Ceramic Society, 74 [3]: 682-685 (1991).
2. RM McMeeking and LT Kuhn. A Diffusional Creep Law for Powder Compacts, Acta Metallurgica et Materialia, 40 [5]: 961-969 (1991).
3. LT Kuhn and RM McMeeking. Power Law Creep of Metal Powder Bonded By Isolated Contacts, International Journal of Mechanical Sciences, 34: 563-573 (1991).
4. NA Fleck, LT Kuhn and RM McMeeking. Yielding of Metal Powder Bonded by Isolated Contacts, Journal of Mechanics and Physics of Solids, 40 [5]:1139-1162 (1992).
5. G Behrens, LT Kuhn, R Ubic and AH Heuer. Raman Spectra of Vateritic Calcium Carbonate, Spectroscopy Letters, 28 [6]: 983-995 (1995).
6. H Kessler, R Ballarini, RL Mullin, LT Kuhn and AH Heuer. A Biomimetic Example of Brittle Toughening: I. Steady state multiple cracking, J. of Computational Materials Science, 5: 157-166 (1996).
7. LT Kuhn-Spearing*, H Kessler, SM Spearing, R Ballarini and AH Heuer. Fracture Mechanisms of the Strombus Gigas Conch Shell: Implications for the Design of Brittle Laminates, Journal of Materials Science, 31:6583-6594 (1996).
8. J-Y Rho, L Kuhn-Spearing and P Zioupos, Mechanical properties and the hierarchical structure of bone, Medical Engineering and Physics, 20: 92-102 (1998). Cited 363 times according to Google Scholar accessed on 8/30/10.
9. LT Kuhn, Y Wu, C Rey, L Gerstenfeld, M Grynpas, J Ackerman, H-M Kim, and MJ Glimcher.  Structure, Composition and Maturation of Newly Deposited Calcium-Phosphate Crystals in Chicken Osteoblast Cell Cultures, Journal of Bone and Mineral Research, 15(7):1301-1309 (2000).
10. C-K Loong, C Rey, LT Kuhn, C Combes, Y Wu, S-H Chen and MJ Glimcher. Evidence of Hydroxyl-Ion Deficiency in Bone Apatites: An Inelastic Neutron Scattering Study, Bone, 26(6): 599-602 (2000).
11. SJ Eppell, W Tong, JL Katz, LT Kuhn, MJ Glimcher.  Shape and Size of Isolated Bone Mineralites Measured Using Atomic Force Microscopy, Journal of Orthopaedic Research, 19: 1027-1034 (2001).
12. W Tong, MJ Glimcher, JL Katz, LT Kuhn, SJ Eppell.  Size and Shape of Mineralites in Young Bovine Bone Measured by Atomic Force Microscopy, Calcified Tissue International, 72: 592-598 (2003).
13. Barroug, LT Kuhn*, LC Gerstenfeld, MJ Glimcher. Interactions of cisplatin with calcium phosphate nanoparticles: in vitro controlled adsorption and release, Journal of Orthopaedic Research 22:703-708 (2004).
14. X Cheng and LT Kuhn*. Chemotherapy Drug Delivery from Calcium Phosphate Nanoparticles, Int. J. of Nanomedicine. 2(4):667-674 (2007).
15. M Ramesh, LT Turner, R Yadav, TV Rajan, AT Vella, and LT Kuhn*, Effects of the Physico-Chemical Nature of Two Biomimetic Crystals on the Innate Immune Response, International Immunopharmacology 7: 1617-1629 (2007).
16. M Freilich, C Patel, M Wei, D Shafer, P Schleier, P Hortschansky, R Kompali, L Kuhn*. Growth of a new layer of bone guided by implants in a novel murine calvaria model, Bone, 43(4): 781-8 (2008).
17. LT Kuhn*, MD Grynpas, C Rey Y Wu, JL Ackerman, MJ Glimcher. A Comparison of the Physical and Chemical Differences Between Cancellous and Cortical Bovine Bone Mineral at Two Ages, Calcified Tissue International, 83:146-54 (2008).
18. M Freilich, D Shafer, M Wei, R Kompalli, D Adams, L Kuhn. Implant system for guiding a new layer of bone: Computed microtomography and histomorphometric analysis in the rabbit mandible, Clinical Oral Implants Research, 20:201-207 (2009).
19. AJ Goldberg, MC Advincula, Y Liu, G Gronowicz, P Habibovic, and LT Kuhn*.  A rapid, reproducible method for coating tissue culture polystyrene disk inserts with carbonated hydroxyapatite, Journal of Biomaterials Science – Polymer Edition, 21:1371-1387, (2010).
20. CJ Wang, I-P Chen, B Koczon-Jaremko, AL Boskey, Y Ueki, LT Kuhn, EJ Reichenberger. Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties, Bone, 46:1306-1315 (2010).
21. LT Kuhn*, Y Liu, M Advincula, Y-H Wang, P Maye, and AJ Goldberg. Osteoblast specific promoter-driven fluorescence reveals cell patterns of osteogenesis on a biomimetic calcium phosphate surface, Tissue Engineering, 16(6); 1357-1366 (2010).
22. G Ou, LF Charles, SJ Matton, C Rodner, M Hurley, LT Kuhn, and G Gronowicz. Fibroblast-growth factor 2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone, Journal of Gerontology: A Biol Sci Med Sci. 65(10):1051-9 (2010). doi: 10.1093/gerona/glq114. Free access at : http://biomedgerontology.oxfordjournals.org/content/early/2010/07/17/gerona.glq114.full.pdf?ijkey=M93egzuuBKgmXjZ&keytype=ref
23. C Pavlik, N Biswal, FC Gaenzler, MD Morton, LT Kuhn, KP Claffey, Q Zhu, M Smith. Synthesis and Fluorescent Characteristics of Imidazole-Indocyanine Green Conjugates, Dyes and Pigments, 89; 9-15 (2011).  doi: 10.1016/j.dyepig.2010.08.008.
24. B Wen, M Karl, D Pendrys, D Shafer, M Freilich, LT Kuhn*. An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model. Journal of Biomedical Materials Research – B Applied Biomaterials, 97(2):315-26 (2011). doi: 10.1002/jbm.b.31817.
25. M Karl, MA Freilich, B Wen, M Wei, D Shafer, LT Kuhn. A comparison of roughened and alkaline treated titanium implants used to guide a new layer of bone growth on the rabbit mandible, Zeitschrift fur Zahnarztliche Implantologie (Journal of Dental Implantology), 27 (2) (2011). doi: 10.3238/ZZI.2011.0145
26. NC Biswal, C Pavlik, MB Smith, A Aquirre, LT Kuhn, KP Claffey, and Q Zhu. Imaging tumor hypoxia markers by near infrared fluorescence tomography, Journal of Biomedical Optics, 16(6) 066009 (2011). doi: 10.1117/1.3589348
27. M Freilich, B Wen, D Shafer, P Schleier, M Dard, D Pendrys, D Ortiz, L Kuhn.  Implant guided vertical bone growth in the mini-pig, Clinical Oral Implants Research, 2012 Jun;23(6):751-7. doi: 10.1111/j.1600-0501.2011.02199.x.
28. Y Liu, AJ Goldberg, JE Dennis, GA Gronowicz, LT Kuhn*. One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating, PLoS ONE, 2012;7(3):e33225. Doi 10.1371/journal.pone.0033225.
29. Y Liu LF Charles, TI Zarembinski, KI Johnson, SK Atzet, RL Wesselschmidt, ME Wight, LT Kuhn*. Modified hyaluronan hydrogels support the maintenance of mouse embryonic stem cells and human induced pluripotent stem cells.  Macromol Biosci. 2012 Aug;12(8):1034-42. doi: 10.1002/mabi.201200043.
30. S Catros, B Wen, P Schleier, D Shafer, M Dard, M Obrecht, M Freilich, L Kuhn*, Use of a perforated scaffold retaining abutment to achieve vertical bone regeneration around dental implants in the minipig. Int J Oral Maxillofac Implants. 2013 Mar-Apr;28(2):432-43. doi: 10.11607/jomi.2782.
31. L Kuhn, G Ou,  L Charles, M Hurley, C Rodner and G Gronowicz, Fibroblast growth factor-2 and Bone Morphogenetic Protein-2 Have a Synergistic Stimulatory Effect on Bone Formation in Cell Cultures from Aging Mouse and Human Bone, J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1170-80. doi: 10.1093/gerona/glt018.
32. Y Xu, S Zanganeh, I Mohammad, A Aguirre, T Wang, Y Yang, L Kuhn, M Smith, and Q Zhu. Targeting tumor hypoxia with 2-nitroimidazoleindocyanine green dye conjugates. Journal of Biomedical Optics 2013 Jun;18(6):66009, doi: 10.1117/1.JBO.18.6.066009.
33. A Ferrand, S Eap L Richert, S Lemoine, D Kalaskar, S Demoustier-Champagne, H Atmani, Y Mély, F Fioretti, G Schlatter, L Kuhn, G Ladam, and N Benkirane-Jessel. Osteogenetic Properties of Electrospun Nanofibrous PCL Scaffolds Equipped with Chitosan-based Nanoreservoirs of Growth Factors. Macromolecular Bioscience, 2014 Jan; 14(1); 45-55.  DOI: 10.1002/mabi.201300283.
34. L Kuhn*, Y Liu, N Boyd, J Dennis, X Jiang, X Xin, L Charles, L Wang, H Aguila, D Rowe, A Lichtler, AJ Goldberg.  Developmental engineering of bone using human embryonic stem cell-derived mesenchymal cells. Tissue Engineering A, 2014 Jan;20 (1-2):365-77. , doi:10.1089/ten.TEA.2013.0321.
35. Y Liu, AJ Goldberg, HL Aguila, LT Kuhn.  Lectin Concanavalin A coatings for rapid attachment of human embryonic stem cells. Open Journal of Biomedical Engineering, OJBMR 2014, 1(1):6-14. DOI: 10.12966/ojbmr.01.02.2014.
36. L Xiao, D Ueno, S Catros, L Charles, L Kuhn, MM Hurley.  Exported 18-kDa Isoform of Fibroblast Growth Factor-2 Improved Bone Regeneration in Critical Size Mice Calvarial Defects. Endocrinology, 2014 Mar;155(3):965-74. doi: 10.1210/en.2013-1919.
37. X Xin, X Jiang, L Wang, M Stover, S Zhan, J Huang, J Goldberg, Y Liu, L Kuhn, E Reichenberger, D Rowe and A Lichtler. A Site-Specific Integrated Col2.3GFP Reporter Construct Demonstrates in vivo Bone Formation by Human Embryonic Stem Cells, Stem Cells Translational Medicine, 2014 Oct;3(10):1125-37. doi: 10.5966/sctm.2013-0128.
38. G Gronowicz, MM Hurley, and LT Kuhn. Optimizing BMP-2-induced bone repair with FGF-2. J Am Acad Orthop Surg, 2014 ; 22:677-679.
39. B Wen, L Kuhn, L Charles, D Pendrys, D Shafer, M Freilich. Comparison of BMP-2 delivery systems to induce a new layer of bone guided by titanium dental  implants in the rabbit mandible. Submitted to Clin Oral Implants Res, October 2014.
40. M Haeri, K Sagomonyants, M Mina, L Kuhn, AJ Goldberg. Odontogenic differentiation of dental pulp cells cultured on dentin-link microtubular polymer scaffolds in vitro. Submitted to Tiss Egr, October 2014.

Book Chapters

• LT Kuhn, DJ Fink and AH Heuer, “Biomimetic Strategies and Materials Processing” in Biomimetic Approaches in Materials Science, Ed. S. Mann, VCH Publishers, New York, p. 41-68, 1995.
• L Kuhn-Spearing and AH Heuer, “Biomimetic Processing of Ceramics” in Encyclopedia of Applied Physics, Ed. GL Trigg, VCH Publishers, New York, pp. 27-45, 1999.
• LT Kuhn, “Bone Mineralization”, Chapter 8 in Encyclopedia of Materials: Science and Technology, Eds. KHJ Buschow, RW Cahn, MC Flemings, B Ilschner, EJ Kramer, S. Mahajan, Elsevier Science Ltd., pp. 787-794, 2001.
• LT Kuhn, “Biomaterials”, Chapter 6 in Introduction to Biomedical Engineering, Eds. JD Enderle, S Blanchard, and JD Bronzino, Elsevier, 2005.
• LT Kuhn, “Biomaterials”, Chapter 5 in Introduction to Biomedical Engineering, third edition, Eds. JD Enderle, S Blanchard, and JD Bronzino, Elsevier, 2012.
• LT Kuhn and J Goldberg, “Biomaterials” Chapter 5, in Regenerative Engineering, Eds. Y Khan and C. Laurencin, CRC Press/Taylor & Francis Group, 2013. ISBN 9781439814123.
• LT Kuhn*, E Jacobs, and AJ Goldberg, “Evaluation of Bio-Inspired Materials for Mineralized Tissue Regeneration Using Type I Collagen Reporter Cells”, Chapter 14 in Bio-Inspired Materials for Biomedical Engineering, Eds. CM Kirschner and AB Brennan, Wiley, Inc., 2014. ISBN: 978-1-118-36936-4.
• B Wen, M Freilich, L Kuhn*, “Dental implant guided bone tissue engineering”, Chapter 65 in Stem Cell Biology and Tissue Engineering in Dental Sciences, Eds. A Vishwakarma, P Sharpe, S Shi, X-P Wang, M Ramalingam, Academic Press/Elsevier, in press 2014.