Publications

    Theses:
  • Atwood, C.S. (1984) Circadian changes in salivary constituents and conductivity in women and men.  Honours Thesis. Department of Biochemistry, The University of Western Australia, Perth, Australia.
  • Atwood, C.S. (1993) The measurement of fat, protein, lactose and cellular metabolites in milk for the assessment of lactocyte function during the lactation cycle of the sow.  Ph.D. Thesis.  Department of Biochemistry, The University of Western Australia, Perth, Australia.

    Patents:
  • Method of screening for drugs useful in treating Alzheimer's disease (2000), WO0066181. November 9, 2000, Inventors: A.I. Bush, X. Huang, C.S. Atwood, R.E. Tanzi. Abstract: The invention relates to methods for identifying candidate pharmacological agents to be used in the treatment and/or prevention of Alzheimer's disease and/or related pathological conditions.
  • Agents for use in the treatment of Alzheimer's disease (2001), United States Patent No. 6,323,218, November 27, 2001. Inventors: A.I. Bush, X. Huang, C.S. Atwood, R.E. Tanzi. Abstract: The invention relates to the identification of pharmacological agents to be used in the treatment of Alzheimer's disease and related pathological conditions and compositions for treatment of conditions caused by amyloidosis, Abeta-mediated formation of ROS, or both, such as in Alzheimer's disease.
  • Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation (2003), United States Patent No. 6,638,711, October 28, 2003. Inventors: A.I. Bush, X. Huang, C.S. Atwood, R.E. Tanzi. Abstract: The invention relates to methods for identifying candidate pharmacological agents to be used in the treatment and/or prevention of Alzheimer's disease and/or related pathological conditions.
  • Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator (2006).  United States Patent No. 7,045,531, May 16, 2006. Inventors: A.I. Bush, X. Huang, C.S. Atwood, R.E. Tanzi. Abstract: The invention relates to the identification of pharmacological agents to be used in the treatment of Alzheimer's disease and related pathological conditions. Methods and compositions for treatment of conditions caused by amyloidosis, A.beta.-mediated ROS formation, or both, such as Alzheimer's disease, are disclosed.
  • Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis (2012), United States Patent No. 8,110,355, Feb 7, 2012. Inventors: C.S. Atwood, S. Vadakkadath Meethal. Abstract: Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility.
  • Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis (2012), United States Patent No. 8,329,891, Dec 11, 2012. Inventors: C.S. Atwood, S. Vadakkadath Meethal. Abstract: As above.
  • Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis (2012), United States Patent No. 8,716,466, May 6, 2014. Inventors: C.S. Atwood, S. Vadakkadath Meethal. Abstract: As above.
  • Methods for assessing risk of Alzheimer's disease in a patient. Atwood, C.S. United States Patent Application 20100035266.

    Full-Length Papers:
    Refereed Articles Containing Original Data
  • Guppy, M., Bradshaw, S.D., Ferguson, B., Hansen, I.A. and Atwood, C.S.  (1987). Metabolism in lizards: low lactate turnover and advantages of heterothermy.  The American Physiological Society, 253 (Regulatory Integrative Comparative Physiology 22), R77-82.
  • Atwood, C.S., James, I.R., Kiel, U., Roberts, N.K. and Hartmann, P.E.  (1991). Circadian changes in salivary constituents and conductivity in women and men.  Chronobiologia, 18(4), 125-140.
  • Atwood, C.S., Toussaint, J.K. and Hartmann, P.E.  (1991). The concentration of cellular metabolites in sows' milk change during lactogenesis.  In: Manipulating Pig Production III.  Proceedings of the Biennial Conference of the Australasian Pig Science Association (A.P.S.A.), p 74.  Ed E.S. Batterham (Australasian Pig Science Association, Attwood, Victoria, Australia).
  • Atwood, C.S. and Hartmann, P.E. (1992). Collection of fore and hind milk from the sow and the changes in milk composition during suckling.  Journal of Dairy Research, 59(3), 287-298.
  • King, R.H., Toner, M.S., Dove, H., Atwood, C.S. and Brown, W.G. (1993). The response of first-litter sows to dietary protein level during lactation.  Journal of Animal Science, 71, 2457-2463.
  • Atwood, C.S. and Hartmann, P.E. (1993). The concentration of fat, protein and lactose in sows' colostrum from sucked and unsucked glands during lactogenesis II.  Australian Journal of Agricultural Research, 44, 1457-1465.
  • Atwood, C.S. (1993). The measurement of fat, protein, lactose and cellular metabolites in milk for the assessment of lactocyte function during the lactation cycle of the sow.  Ph.D. Thesis.  The University of Western Australia.
  • Atwood, C.S. & Hartmann, P.E. (1995). The assessment of mammary gland metabolism in the sow: The development of methods for the measurement of cellular metabolites in milk and colostrum.  Journal of Dairy Research, 62(2), 189-206.
  • Atwood, C.S., Toussaint, J.K. & Hartmann, P.E. (1995). The assessment of mammary gland metabolism in the sow: Cellular metabolites in the mammary secretion and plasma during lactogenesis II.  Journal of Dairy Research, 62(2), 207-220.
  • Atwood, C.S. & Hartmann, P.E. (1995). The assessment of mammary gland metabolism in the sow: Cellular metabolites in the mammary secretion and plasma following weaning.  Journal of Dairy Research, 62(2), 221-236.
  • Bird, P.H., Atwood, C.S. and Hartmann, P.E. (1995). The responses of blood galactose to oral doses of lactose, galactose plus glucose and milk to piglets.  British Journal of Nutrition, 73, 753-761.
  • Atwood, C.S., Ikeda, M and Vonderhaar, B.K. (1995). Involution of mouse mammary glands in whole organ culture: a model for studying programmed cell death.  Biochemical and Biophysical Research Communications, 207(2), 860-867.
  • Toner, M.S., King, R.H., Dunshea, F.R., Dove, H. and Atwood, C.S. (1996). The effect of exogenous somatotrophin on lactation performance of first-litter sows. Journal of Animal Science, 74, 167-172.
  • Pluske, J.R., Thompson, M.J., Atwood, C.S., Bird, P.H., Williams, I.H & Hartmann, P.E. (1996). Maintenance of villus height and crypt depth, and enhancement of disaccharide digestion and monosaccharide adsorption, in piglets fed on cows’ whole milk after weaning. British Journal of Nutrition, 76, 409-422.
  • Huang, X., Atwood, C.S., Moir, R.D., Hartshorn, M.A., Vonsattel, J-P., Tanzi, R.E. and Bush, A.I. (1997). Zinc-induced Alzheimer’s Aß1-40 aggregation is mediated by conformational factors.  Journal of Biological Chemistry, 272, 26464-26470.
  • Atwood, C.S., Huang, X., Moir, R.D., Bacarra, N.M., Romano, D., Tanzi, R.E. and Bush, A.I. (1998). Dramatic aggregation of Alzheimer Aß by Cu(II) is induced by conditions representing physiological acidosis. Journal of Biological Chemistry, 273, 12817-12826.
  • Chan, C.-W., Dharmarajan, A., Atwood, C.S., Huang, X., Tanzi, R.E., Bush, A.I., and Martins, R.N. (1999). Anti-apoptotic action of Alzheimer Aß. Alzheimer’s Reports, 2(2), 1-6.
  • Moir, R.D., Atwood, C.S., Bush, A.I., Romano, D.M., Huang, X., Smith, J. and Tanzi, R.E. (1999). Differential effects of apolipoprotein E isoforms on metal-induced aggregation of Aß under physiological conditions.  Biochemistry, 38, 4595-4603.
  • Cherny, R.A., Legg, J.T., McLean, C.A., Fairlie, D.P., Huang, X., Atwood, C.S., Tanzi, R.E., Masters, C.L. and Bush, A.I. (1999). Aqueous dissolution of Alzheimer’s disease Aß amyloid deposits by biometal depletion.  Journal of Biological Chemistry, 274, 23223-23228.
  • Huang, X., Cuajungco, M.P., Atwood, C.S., Hartshorn, M.A., Tyndall, J., Hanson, G.R., Stokes, K.C., Multhaup, G., Goldstein, L.E., Scarpa, R.C., Saunders, A.J., Lim, J., Moir, R.D., Glabe, C., Bowden, E.F., Masters, C.L., Fairlie, D.P., Tanzi, R.E. and Bush, A.I. (1999).  Alzheimer Aß interaction with Cu(II) induces neurotoxicity, radicalization, metal reduction and hydrogen peroxide formation. Journal of Biological Chemistry, 274, 37111-37116.
  • Huang, X., Atwood, C.S., Hartshorn, M.A., Multhaup, G., Goldstein, L.E., Scarpa, R.C., Cuajungco, M.P., Gray, D.N., Lim, J., Moir, R.D., Tanzi, R.E. and Bush, A.I.  (1999). The Aß peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry, 38, 7609-7616.
  • Atwood, C.S., Huang, X., Khatri, A., Scarpa, R.C., Kim, Y.-S., Moir, R.D., Tanzi, R.E., Roher, A.E., and Bush, A.I. (2000). Copper catalyzed oxidation of Alzheimer Aß. Cellular and Molecular Biology, 46(3), 777-783.
  • Goldstein, L.E., Hartshorn, M., Leopold, M., Huang, X., Atwood, C.S., Saunders, A.J., Lim, J., Scarpa, R.C., Chylack, L.T. Jr., Bowden, E.F., Tanzi, R.E. & Bush, A.I. (2000). 3-Hydroxykynurenine and 3-Hydroxyanthranilic acid generate hydrogen peroxide and promote crystallin crosslinking by metal ion reduction.  Biochemistry, 39(24), 7266-7275.
  • Cuajungco, M.P., Goldstein, L.E., Nunomura, A., Smith, M.A., Lim, J.T., Atwood, C.S., Huang, X., Farrag, Y.W., Perry, G. and Bush, A.I. (2000). Evidence that the ß-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aß by zinc. Journal of Biological Chemistry, 275, 19439-19442.
  • Atwood, C.S., Hovey, R., Glover, J.P., Chepko, G., Ginsburg, E., Robison, Jr., W.G. and Vonderhaar, B.K.  (2000). Progesterone induces ductal side-branching of the ductal epithelium in the mammary glands of peripubertal mice. Journal of Endocrinology, 167, 39-52.
  • Atwood, C.S., Scarpa, R.C., Huang, X., Moir, R.D., Jones, W.D., Fairlie, D.P., Tanzi, R.E. and Bush, A.I. (2000). Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta1-42. Journal of Neurochemistry, 75, 1219-1233.
  • Fonte, J., Miklossy, J., Atwood, C.S. and Martins, R. (2001).  Alzheimer’s disease neuropathology is positively correlated with increased beta amyloid levels: Resolubilization with transition metal chelators. Journal of Alzheimer Disease, 3, 209-219.
  • Hirai, K., Aliev, G., Nunomura, A., Russell, R.L., Atwood, C.S., Johnson, A.B., Kress, Y.,Vinters, H.V., Tabaton, M., Cash, A., Siedlak, S.L., Jones, P.K., Petersen, R.B., Perry, G. and Smith, M.A. (2001). Mitochondrial DNA turnover is decreased in oxidatively stressed pyramidal neurons of the Alzheimer’s disease brain.  Journal of Neuroscience, 21, 3017-3023.
  • Rottkamp, C.A., Raina, A.K., Zhu, X., Gaier, E., Bush, A.I., Atwood, C.S., Chevion, M., Perry, G., Smith, M.A. (2001). Redox-active iron mediates amyloid-beta toxicity.  Free Radicals in Biology and Medicine, 30, 447-450.
  • Cherny, R.A.*, Atwood, C.S*., Xilinas, M.E., Gray, D.N., Jones, W.D., McLean, C.A. Barnham, K.J., Volitakis, I., Fraser, F.W., Kim, Y.-S., Huang, X., Goldstein, L.E., Moir, R.D., Lim, J.T., Beyreuther, K.T., Zheng, H., Tanzi, R.E., Masters, C.L. and Bush, A.I. (2001). Treatment of a copper-zinc chelator markedly and rapidly inhibits ß-Amyloid accumulation in Alzheimer disease transgenic mice. Neuron, 30, 665-676. * First two authors contributed equally.
  • Castellani, R.J., Harris, P.L., Sayre, L.M., Fujii, J., Taniguchi, N., Vitek, M.P., Founds, H., Atwood, C.S., Perry, G., Smith, M.A. (2001) Active glycation in neurofibrillary pathology of Alzheimer disease: N(varepsilon)-(Carboxymethyl) lysine and hexitol-lysine. Free Radicals in Biology and Medicine, 31, 175-180.
  • Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E.K., Jones, P.K., Ghanbari, H., Wataya, T., Shimohama, S., Chiba, S., Atwood, C.S., Petersen, R.B., Smith, M.A. (2001).  Oxidative damage is the earliest event in Alzheimer disease.  Journal of Neuropathology and Experimental Neurology, 60, 759-767.
  • Zhu, X., Castellani, R.J., Takeda, A., Nunomura, A., Atwood, C.S., Perry, G., Smith, M.A.  (2001). Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mechanisms of Ageing Development, 123, 39-46.
  • Bowen, R.L., Smith, M.A., Harris, P.L.R., Kubat, Z., Martins RN, Castellani, R.J., Perry, G. and Atwood, C.S.  (2002). Elevated luteinizing hormone expression colocalizes with neurofibrillary tangles in Alzheimer disease. Journal of Neuroscience Research, 70(3), 514-518.
  • Perry, G., Taddeo, M.A., Petersen, R.B., Castellani, R.J., Harris, P.L.R., Sidlak, S.L., Cash, A.D., Liu, Q, Nunomura, A., Atwood, C.S., Smith, M.A. (2003). Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer's disease. Biometals, 16, 77-81.
  • Veurink, G., Liu, D., Taddei, K., Perry, G., Smith, M.A., Robertson, T.A., Hone, E., Groth, D.M., Atwood, C.S. and Martins, R.N. (2003). Reduction of inclusion body pathology in Apo-E-deficient mice fed a combination of antioxidants. Free Radicals in Biology and Medicine, 34(8), 1070-1077.
  • Dong, J., Atwood, C.S., Anderson, V.E., Siedlak, S.L., Smith, M.A., Perry, G. and Carey, P.R. (2003). Metal binding and oxidation of amyloid-ß within isolated senile plaque cores: Raman microscopic evidence. Biochemistry, 42(10), 2768-2773.
  • Atwood, C.S., Perry, G., Zeng, H., Kato, Y., Jones, W.D., Ling, K.Q., Huang, X., Moir, R.D., Wang, D., Sayre, L.M., Smith M.A., Chen, S.G. and Bush, A.I. (2004). Copper mediated crosslinking reactions of Alzheimer's amyloid-ß. Biochemistry, 43(2), 560-568.
  • Liu, T., Perry, G., Chan, H.W., Verdile, G., Martins, R.N., Smith, M.A. and Atwood, C.S. (2004). Amyloid-ß-induced toxicity of primary neurons is dependent upon differentiation associated increases in tau and cyclin-dependent kinase 5. Journal of Neurochemistry, 88(3), 554-563.
  • Bowen, R.L., Verdile, G., Liu, T., Perry, G., Smith, M.A., Martins, R.N. and Atwood, C.S. (2004). Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-ß protein precursor and amyloid-ß deposition.  Journal of Biological Chemistry, 279(19), 20539-45.
  • Zhu, X., McShea, A., Harris, P.L.R., Raina, A.K., Castellani, R.J., Funk, J.O., Shah, S., Atwood, C.S., Bowen, R., Bowser, R., Morelli, L., Perry, G. and Smith, M.A. (2004). Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer’s disease. Journal of Neuroscience Research, 75, 698–703.
  • Zhu, X., Wang, Y., Ogawa, O., Lee, H.G., Raina, A.K., Siedlak, S.L., Harris, P.L., Fujioka, H., Shimohama, S., Tabaton, M., Atwood, C.S., Petersen, R.B., Perry, G., Smith, M.A. (2004). Neuroprotective properties of Bcl-w in Alzheimer disease.  Journal of Neurochemistry, 89, 1233-1240. 
  • Bowen, R.L. and Atwood, C.S. (2004). Living and Dying for Sex: A theory of aging based on the modulation of cell cycle signaling by reproductive hormones. Gerontology, 50(5), 265-290.
  • Huang, X., Atwood, C.S., Moir, R.D., Hartshorn, M.A., Tanzi, R.E. and Bush, A.I. (2004). Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. Journal of Biological Inorganic Chemistry, 9, 954-960.
  • Cui, Z., Lockman, P.R., Atwood, C.S., Hsu, C.-H., Gupte, A., Allen, D.D. and Mumper, R.J. (2005). Novel D-penicillamine carrying nanoparticles for potential treatment of ß-amyloid accumulation in brain.  European Journal of Pharmaceutics and Biopharmaceutics, 59, 263-272.
  • Casadesus, G., Webber, K.M., Atwood, C.S., Pappolla, M.A., Perry, G., Bowen, R.L. and Smith, M.A. (2006). Luteinizing hormone modulates cognition and amyloid-ß deposition in Alzheimer APP transgenic mice. Biochemica Biophyica. Acta 1762(4), 447-452.
  • Webber, K.M., Stocco, D.M., Casadesus, G., Bowen, R.L., Atwood, C.S., Previll, L.A., Harris, P.L., Zhu, X., Perry, G., Smith, M.A. (2006) Steroidogenic acute regulatory protein (StAR): Evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Molecular Neurodegeneration, 1, 14. 
  • Atwood, C.S. and Bowen, R.L.  (2006). Metabolic clues regarding the enhanced performance of elite endurance athletes from orchiectomy-induced hormonal changes.  Medical Hypotheses, 68(4), 735-749. (Epub 2006 Nov 13).
  • Vadakkadath Meethal, S., Gallego, M., Haasl, R.J., Petras, S.J., Sgro, J.Y., Bowen, R.L. and Atwood, C.S. (2006). Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans. BMC Evolutionary Biology, 6:103.  Selected as a Research Highlight paper online. 
  • Wilson, A.C., Salamat, S., Haasl, R.J., Roche, K.M., Karande, A., Vadakkadath Meethal, S., Terasawa, E., Bowen, R.L. and Atwood, C.S. (2006). Human extra-pituitary neurons possess GnRH I receptors that respond to GnRH by expressing luteinizing hormone. Journal of Endocrinology, 191, 651-665.
  • Wung, J.K., Perry, G., Kowalski, A.., Harris, P.L.R., Bishop, G.M., Trivedi, M.A., Johnson, S.C., Smith, M.A., Denhardt, D.T. and Atwood, C.S. (2007) Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain. Current Alzheimer Research, 4(1), 67-72.
  • Liu, T., Wimalasena, J., Bowen, R.L. and Atwood, C.S.  (2007). Luteinizing hormone receptor mediates neuronal pregnenolone production via upregulation of steroidogenic acute regulatory protein expression. Journal of Neurochemistry, 100(5), 1329-1339.
  • Porayette, P., Gallego, M.J., Kaltcheva, M.M., Vadakkadath Meethal, S. and Atwood, C.S. (2007). Amyloid-b precursor protein expression and modulation in human embryonic stem cells: A novel role for human chorionic gonadotropin.  Biochemical and Biophysical Research Communications, 364(3), 522-527.
  • Bishop, G.M., Smith, M.A., LaManna, J.C., Wilson, A.C., Perry, G., Atwood, C.S.  (2007). Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia. Redox Report 12(6), 257-266.
  • Chan, H.W., Liu, T., Verdile, G., Bishop, G.M., Haasl, R.J., Smith, M.A., Perry, G., Martins, R.N. and Atwood, C.S.  (2008). Copper induces apoptosis of neuroblastoma cells via post-translational regulation of the expression of Bcl-2-family proteins and the txJ mouse is a better model of hepatic than brain Cu toxicity.  International Journal of Clinical and Experimental Medicine, 1, 76-86.
  • Trivedi, M.A., Schmitz, T.W., Ries, M.L., Hess, T.M., Fitzgerald, M.E., Atwood, C.S., Rowley, H.A., Asthana, S., Sager, M.A. and Johnson, S.C. (2008). fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: Risk factors for Alzheimer's disease. Neuropsychologia. 46(6), 1667-1678.
  • Gonzalez-Cuyar, L.F., Perry, G., Miyajima, H., Atwood, C.S., Riveros-Angel, M., Lyons, P.F., Siedlak, S.L., Smith, M.A., Castellani, R.J. (2008). Redox active iron accumulation in aceruloplasminemia. Neuropathology. 28(5), 466-471.
  • Atwood, C.S. and Bowen, R.L. (2008). A multi-hit endocrine model of intrinsic adult-onset asthma.  Ageing Research Reviews, 7(2):114-125.
  • Carlsson, C.M., Gleason, C.E., Hess, T.M., Moreland, K.A., Blazel, H.M., Koscik, R.L., Schreiber, N.T.N., Johnson, S.C., Atwood, C.S., Puglielli, L., Hermann, B.P., McBride, P.E., Stein, J.H., Sager, M.A. and Asthana, S. (2008). Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer’s disease. Journal of Alzheimer’s Disease, 13(2), 187-97.
  • Wilson, A.C., Clemente, L., Liu, T., Bowen, R.L., Vadakkadath Meethal, S. and Atwood, C.S. (2008). Reproductive hormones regulate the selective permeability of the blood-brain barrier.  Biochimica et Biophysica Acta - Molecular Basis of Disease, 1782(6), 401-407.
  • Rodrigues, M.A., Verdile, G., Foster, J.K., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E.H., Laws, S.M., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C.S. and Martins, R.N. (2008). Gonadotropins and cognition in older women. Journal of Alzheimer’s Disease, 13(3), 267-274.
  • Haasl, R.J., Reza Ahmadi, M., Vadakkadath Meethal, S., Gleason, C.E., Johnson, S.C., Asthana, S., Bowen, R.L. and Atwood, C.S. (2008).  A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer’s disease in males carrying an apolipoprotein E e4 Allele. BMC Medical Genetics, 9(1):37.
  • Friedland, R.P., Tedesco, J., Wilson, A.C., Atwood, C.S., Smith, M.A., Perry, G. and Zagorski, M.G. (2008).  Antibodies to potato virus Y bind the Ab protein: Immunohistochemical and NMR studies.  Journal of Biological Chemistry, 283(33), 22550-22556.
  • Gallego, M., Porayette, P., Kaltcheva, M., Bowen, R., Vadakkadath Meethal, S. and Atwood, C. Trophoblastic hormones direct early human embryogenesis. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2671.1> (2008)
  • Gallego, M.J., Porayette, P. Kaltcheva, M.M., Vadakkadath Meethal, S. and Atwood, C.S. (2009). Opioid and progesterone signaling is obligatory for early human embryogenesis.  Stem Cells and Development, 18(5), 737-740.
  • Gleason, C.E., Carlsson, C.M., Barnet, J.H., Meade, S.A., Setchell, K.D., Atwood, C.S., Johnson, S.C., Ries, M.L., Asthana, S. (2009). A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age and Ageing, 38(1), 86-93.
  • Xu, G., McLaren, D.G., Ries, M.L., Fitzgerald, M.E., Bendlin, B.B., Rowley, H.A., Sager, M.A., Atwood, C., Asthana S. and Johnson, S.C. (2009). The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory. Brain. 132(2), 383-91. PMCID 2724919.
  • Siedlak, S., Casadesus, G., Webber, K.M., Pappolla, M., Atwood, C.S., Smith, M.A. and Perry, G. (2009).  Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer disease. Free Radical Research, 43(2), 156-164.
  • Simon, D., Vadakkadath Meethal, S., Wilson, A.C., Gallego, M.J., Weinecke, S.L., Bruce, E., Lyons, P., Haasl, R.J., Bowen, R.L. and Atwood, C.S. (2009).  Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. Neoplasia, 11(4), 365-376.
  • Vadakkadath Meethal, S., Liu, T., Chan, H., Ginsburg, E., Wilson, A.C., Gray, D.N., Bowen, R.L., Vonderhaar, B.K. and Atwood, C.S. (2009). Identification of a regulatory loop for the synthesis of neurosteroids: A StAR-dependent mechanism involving HPG axis receptors. Journal of Neurochemistry, 110, 1014-1027.
  • Porayette, P., Gallego, M.J., Kaltcheva, M.M., Bowen, R.L., Vadakkadath Meethal, S. and Atwood, C.S. (2009).  Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. Journal of Biological Chemistry, 284(35), 23806-23817.
  • Gallego, M.J., Porayette, P., Kaltcheva, M.M., Bowen, R.L., Vadakkadath Meethal, S. and Atwood, C. S. (2010).  The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes. Stem Cell Research & Therapy, 1:28.
  • Clark, I.A. and Atwood, C.S. (2011). Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease? Journal of Alzheimer’s Disease, 27(4), 691-699.
  • Vadakkadath Meethal, S. and Atwood, C.S. (2012). Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis. Neurobiology of Aging, 33 (3), 569-581.
  • Roetker, N.S., Yonker, J.A., Lee, C., Chang, V., Basson, J.J., Roan, C.L., Hauser, T.S., Hauser, R.M., Atwood, C.S. (2012). Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study. BMJ Open, 2(4). doi:pii: e000944. 10.1136/bmjopen-2012-000944. Print 2012.
  • Chabris, C.F., Hebert, B.M., Benjamin, D.J., Beauchamp, J., Cesarini, D., van der Loos, M., Johannesson, M., Patrik K.E., Lichtenstein, P., Atwood, C.S., Freese, J., Hauser, T.S., Hauser, R.M., Christakis, N. and Laibson, D. (2012). Most reported genetic associations with general intelligence are probably false positives. Psychological Science, 23(11):1314-23. doi: 10.1177/0956797611435528. Epub 2012 Sep 24.
  • Yonker, J.A., Chang, V., Roetker, N.S., Hauser, T.S., Hauser, R.M. and Atwood, C.S. (2013) Hypothalamic-pituitary-gonadal axis homeostasis predicts longevity. Age (Dordr). 35(1), 129-138. doi: 10.1007/s11357-011-9342-1. Epub 2011 Dec 4.
  • Roetker, N.S., C. David Page, Yonker, J.A., Chang, V., Roan, C.L., Herd, P., Hauser, T.S., Hauser, R.M. and Atwood, C.S. (2013) Assessment of genetic and non-genetic interactions for the prediction of depressive symptomology: An analysis of the Wisconsin Longitudinal Study using machine learning algorithms. American Journal of Public Health, 103 Suppl 1:S136-144.
  • Kaltcheva, M.S., Porayette, P., Vadakkadath Meethal, S., Bowen, R.L. and Atwood, C.S. Progesterone induction of tau phosphorylation during embryonic neural precursor cell differentiation: A distinctive feature of proliferating neurons during embryogenesis with correlates to post-mitotic neurons of the Alzheimer’s disease brain.  Neurotoxicity Research. (submitted)

Book Chapters/Book Reviews/Commentaries/Letters to Editor:

  • Hartmann, P.E., Daly, S.E.J. and Atwood, C.S. (1991). The endocrine and autocrine control of milk synthesis.  Molecular Biology and Milk Production.  In: Proceedings of the Dairy Research and Development Corporation of Australia. pp. 77-85.  Eds. Donnelly, P. & McDowell, G.H. (DRDC Press, Melbourne, Australia).
  • Hartmann, P.E., Thompson, M.J., Kennaugh, L.M. and Atwood, C.S.  (1995). Metabolic Regulation of Sow Lactation.  In: Manipulating Pig Production V.  pp. 94-100.  Eds. Hennessy, D.P. and Cranwell, P.D. (Australasian Pig Science Association, Werribee, Victoria, Australia).
  • Hartmann, P.E., Atwood, C.S., Cox, D.B. & Daly, S.E.J. (1995). Endocrine and autocrine strategies for the control of lactation in women and sows.  In: Intercellular Signalling in the Mammary Gland.  pp. 203-225.  Eds. Wilde, C.J. (Plenum Press, New York, USA).
  • Atwood, C.S., Moir, R.D., Huang, X., Tanzi, R.E. and Bush, A.I. (1997). Cerebral zinc metabolism in Alzheimer’s disease.  In: Molecular Mechanisms of Dementia.  pp. 225-237 Eds. Tanzi, R.E., Wasco, W. (Humana Press Inc., Totowa, NJ).
  • Atwood, C.S., Huang, X., Moir, R.D., Tanzi, R.E. and Bush, A.I. (1997). Neurochemical environments that precipitate Aß. In: Alzheimer’s Disease: Biology, Diagnosis and Therapeutics. pp. 329-337.  Eds. Iqbal, K., Winblad, B., Nishimura, T., Takeda, M. and Wisniewski, H.M. (John Wiley & Sons Ltd, Chichester).
  • Huang, X., Atwood, C.S., Goldstein, L.E., Hartshorn, M.A., Saunders, A.J., Moir, R.D., Tanzi, R.E. and Bush, A.I.  (1999). Metal-catalyzed Redox Activity of Aß: The Major Source of Amyloid-associated Oxidative Stress in Alzheimer's Disease.  In: Alzheimer’s Disease and Related Disorders.  pp. 383-390, Eds. Iqbal, K., Swaab, D.F., Winblad, M. and Wisniewski, H.M. John Wiley & Sons Ltd, Chichester.
  • Atwood, C.S., Huang, X., Moir, R.D., Tanzi, R.E. and Bush, A.I.  (1999). The Role of Free Radicals and Metal Ions in the Pathogenesis of Alzheimer's Disease.  In: Interrelations between Free Radicals and Metal Ions in Life Processes", Vol. 36 of 'Metal Ions in Biological Systems', pp. 309-364, Eds., A. Sigel and H. Sigel; M. Dekker, Inc., New York, Basel, Hong Kong.
  • Perry, G., Nunomura, A., Friedlich, A.L., Boswell, M.V., Brazdil, L., Jones, P.K., Rottkamp, C.A., Zhu, X., Raina, A.K., Hirai, K., Friedland, R.P., Shi, J., Aliev, G., Cash, A., Russell, R.L., Wataya, T., Shimohama, S., Atwood, C.S. and Smith, M.A. (2000). Factors Controlling Oxidative Damage in Alzheimer Disease: Metals and Mitochondria In: Free Radicals in Chemistry, Biology and Medicine. pp 417-423, Eds., Yoshikawa, T., Toyokuni, S., Yamamoto, Y., and Naito, Y., OICA International.
  • Atwood, C.S., Huang, X., Moir, R.D., Smith, M.A., Tanzi, R.E. Roher, A.E., Bush, A.I. and Perry, G. (2001).  Neuroinflammatory Responses in the Alzheimer’s Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics pp. 341-361, Eds. K. Iqbal, S.S. Sisodia and Bengt Winblad, John Wiley & Sons, Ltd., UK.
  • Perry, G., Nunomura, A., Avila, J., Perez, M., Rottkamp, C.A., Atwood, C.S., Zhu, X., Aliev, G., Cash, A. and Smith, M.A. (2000). Oxidative Damage and Antioxidative Responses in Alzheimer’s Disease. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics pp. 371-378, Eds. K. Iqbal, S.S. Sisodia and Bengt Winblad, John Wiley & Sons, Ltd., UK.
  • Castellani, R.J., Atwood, C.S., Perry, G., Petersen, R.B. and Smith, M.A. (2002).  In: Prion Diseases and Copper Metabolism: BSE, Scrapie and CJD Research, Brown D.R. Ed. Horwood Publishing, Chichester, pp. 96-101.
  • Atwood, C.S., Smith, M.A., Martins, R.N., Tanzi, R.E. Roher, A.E., Bush, A.I. and Perry, G.  (2003). Neuroinflammatory Environments Promote Amyloid-ß Deposition and Posttranslational Modification. In: Neuroinflammation 2nd Edition: Mechanisms and Management. pp. 249-266, Eds. P. L. Wood, Humana Press Inc., Totowa, NJ.
  • Cash, A.D., Srinivas, R., Rottkamp, C.A., Zhu, X., Taddeo, M.A., Aliev, G., Fujioka, H., Atwood, C.S., Sayre, L.M., Catellani, R.J., Smith, M.A. and Perry, G. (2003). Metal Homeostasis and Its Relation to Oxidative Stress in Alzheimer’s Disease. Redox-Genome Interactions in Health and Disease, Marcel Dekker Inc.  425-437.
  • Bowen, R., Atwood, C.S., Perry, G. and Smith, M.A. (2004). Mechanisms Involved in Gender Differences in Alzheimer’s Disease:  The Role of Luteinizing and Follicle Stimulating Hormones. Principles of Gender-Specific Medicine, Legato, M.L., Ed., Academic Press, pp1234-1237.
  • Obrenovich, M. E., Raina, A. K., Ogawa, O., Atwood, C.S., Smith, M. A. Alzheimer Disease (2005). A New Beginning, Or A Final Exit?, In: Cell Cycle Mechanisms and Neuronal Cell Death, Eds. Copani, A. and Nicoletti, F.  Eurekah.com and Kluwer Academic / Plenum Publishers.
  • Casadesus, G., Webber, K.M., Atwood, C.S., Bowen, R.L., Perry, G., Smith, M.A. (2007). Luteinizing Hormone Mediates Alzheimer-type Changes in Neurons. In: Alzheimer’s Disease: New Advances, pp307-310, Eds. Khalid Iqbal, Bengt Winblad, Jesus Avila, Medimond.
  • Webber, K.M., Stocco, D.M., Casadesus, G., Bowen, R.L., Atwood, C.S., Previll, L.A., Harris, P.L.R., Zhu, X., Perry, G., Smith, M.A. (2007). Steroidogenic Acute Regulatory Protein (StAR): Evidence of Gonadotropin-induced Steroidogenesis in Alzheimer Disease. In: Alzheimer’s Disease: New Advances, pp581-584, Eds. Khalid Iqbal, Bengt Winblad, Jesus Avila, Medimond.
  • Atwood, C.S., Axton, M., Effros, R., Jokerst, N., Labov, J.B., Longo, V., Magalhaes, J., Turteltaub, K., Wolkow, C., Mackenzie, N. (2008), Task Group B.  The National Academies Keck Futures Initiative. Cellular and Molecular Mechanisms of Biological Aging: The Roles of Nature, Nurture, and Chance in the Maintenance of Human Healthspan.  In: The Future of Human Healthspan (Demography, Evolution, Medicine and Bioengineering), The National Academies Press, Washington, DC. pp 88-91.
  • Zhu, X.., Casadesus, G., Webber, K.M., Atwood, C.S., Bowen, R.L., Perry, G. and Smith, M.A. (2008) Parallels between neurodevelopment and neurodegeneration: a case study of Alzheimer’s disease. In Handbook of Neurochemistry and Molecular Neurobiology: Developmental and Aging Changes in the Nervous System, Perez-Polo, J.R. and Rossner, S. (Vol. Eds.). Springer Science+Business Media, LLC, New York, pp 147-155.
  • Atwood, C.S., Boyden, E., Celikel, T., Culurciello, E, Dzakpasu, R., Heilshorn, S., Kello, C., Lathrop, D., Lauren Lee, J., Litt, B., Maas, S., Sporns, O. and Sternad, D. (2009). Task Group 6B.  The National Academies Keck Futures Initiative. The Brain is the Epitome of Complexity.  In: Complex Systems.  The National Academies Press, Washington, DC. pp 49-58.
  • Vadakkadath Meethal, S., Porayette, P., Wilson, A.C., Basson, J., Liu, T. and Atwood, C.S. (2010). Functional consequences of gonadotropin signaling in the brain during development, adulthood and senescence, In: Gonadal and Nongonadal Actions of Gonadotropins. Narosa Publishing House Pvt. Ltd., New Delhi, India, Chapter 23, pp 249-274. ISBN (13): 9788173199837
  • Atwood, C.S. (2010). Amyloid-β aggregation as a protective acute-phase response to injury/neurodegeneration: A barrier function for amyloid-β deposits.  In: Functional Amyloid Aggregation. Eds. Stefania Rigacci and Monica Bucciantini.  Research Signpost, Kerala, India, pp 115-134.  ISBN: 978-81-308-0425-5
  • Atwood, C.S. and Vadakkadath Meethal, S. (2011). Gonadotropins and Progestogens: Obligatory Developmental Functions during Early Embryogenesis and their Role in Adult Neurogenesis, Neuroregeneration, and Neurodegeneration.  In: Hormones in Neurodegeneration, Neuroprotection and Neurogenesis, Eds. Achille Gravanis and Synthia Mellon, WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany.  Chapter 18, pp 305-319. ISBN: 978-3-527-31920-6
  • Atwood, C.S. and Vadakkadath Meethal, S. (2011).  Human Embryonic Stem Cells as a Model System for Understanding Early Human Embryogenesis and Age-related Diseases. In: Embryonic Stem Cells. Ed. Craig S. Atwood.  InTech, Rijeka, Croatia. Chapter 14, 251-270.  ISBN: 978-953-307-196-1

 

 

 

 

Craig S. Atwood

Associate Professor

 

  • : (608) 256 1901 Ext. 11664
    Fax No.:(608) 280 7291

  • DEPARTMENTStem Cell and Regenerative Medicine Center
    University of Wisconsin
  • COUNTRY USA