Publications

  1. Arnaout MA, Salti I. Phenytoin in benign insulinoma. Lancet 1976; I: 861.
  2. Freiha R, Salti I, Arnaout MA, Uthman S, Katchadourian A. Hereditary xanthinuria: Report of three cases and brief review of the literature. Nephron 1977; 19:328.
  3. Arnaout MA, Davis AE, Rosen FS, Alper CA. Complement activation in semi-solid media: Insolubilization of  alternative  pathway  convertases  with  nephritic  factor-containing  sera. J Immunol 1977; 119:1316-1320.
  4. Davis AE, Arnaout MA, Alper CA, Rosen FS. Transfer of nephritic factor from mother to fetus.Is NeF and IgG? N Engl J Med 1977; 297:144-145.
  5. Herman JJ, Rosner IK, Davis AE, Zeiger RS, Arnaout MA, Colten HR. Complement dependent histaminase release from human granulocytes. J Clin Invest 1978; 63:1195-1202.
  6. Arnaout MA, Stossel TP, Alper CA, Rosen FS. Studies on solid phase C3 fragments deposited on     cross-linked            dextran    gel    beads:    Analysis    and    opsonic    activity.    Clin Immunol Immunopathol 1979; 14:384-394.
  7. Arnaout MA, Luscinskas  FW, Lionetti  FJ, Alper CA,  Valeri CR.  Alternative complement pathway-dependent ingestion of luocite particles by human granulocytes. J Immunol 1981; 127:278-281.
  8. Arnaout MA, Melamed J, Tack BF, Colten HR. Characterization of the human C3b receptor using a fluid phase C3b dimer. J Immunol 1981; 127:1348-1354. 
  9. Pennington JE, Hickey WF, Blackwood LL, Arnaout MA. Active immunization with lipopolysaccharide pseudomonas antigen for chronic pseudomonas broncho-pneumonia in guinea pigs. J Clin Invest 1981; 68:1140-1148.
  10. Arnaout MA, Pitt J, Cohen HJ, Melamed J, Rosen FS, Colten HR. Deficiency of a granulocyte- membrane glycoprotein (gp150) in a boy with recurrent bacterial infections. N Engl J Med 1982; 306:693-699.
  11. Melamed J, Arnaout MA, Colten HR. Complement (C3b) interaction with the human granulocyte receptor: Correlation of binding of fluid-phase radiolabeled ligand with histaminase release. J Immunol 1982; 129:2313-2318.
  12. Arnaout MA, Dana N, Melamed J, Medicus R, Colten HR. Low ionic strength or chemical crosslinking of monomeric C3b increases its binding affinity to the human C3b receptor. Immunol 1983; 48:229-237.
  13. Medicus RG, Melamed J, Arnaout MA. Role of human factor I and C3b receptor in the cleavage of surface bound C3bi molecules. Eur J Immunol 1983; 13:465-470.
  14. Melamed J, Medicus RG, Arnaout MA, Colten HR. Induction of granulocyte histaminase release by particle bound complement C3 cleavage products (C3b, C3bi) and IgG. J Immunol 1983; 131:439-444.
  15. Arnaout MA, Todd RF, Dana N, Melamed J, Schlossman SF, Colten HR. Inhibition of phagocytosis of complement C3 or IgG coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest 1983; 72:171-179.
  16. Dana N, Todd RF, Pitt J, Springer T, Arnaout MA. Deficiency of a surface membrane glycoprotein (Mol) in man. J Clin Invest 1984; 73:153-159.
  17. Goldberger G, Arnaout MA, Aden DP, Kay RM, Rits M, Colten HR. Biosynthesis and post synthetic processing of human C3b/C4b inactivator (factor I) in three hepatoma cell lines. J Biol Chem 1984; 259:6492-6497.
  18. Anderson DC, Schmalsteig FC, Arnaout MA, Kohl S, Tosi MF, Dana N, Buffone GJ, Hughes BJ, Brinkley BR, Dickey WD, Abramson JS, Springer T, Boxer LA, Hollers JM, Smith CW. Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of a high molecular weight surface glycoproteins (GP138): Common relationship to diminished cell adherence. J Clin Invest 1984; 74:536-551.
  19. Arnaout MA, Spits H, Terhorst C, Pitt J, Todd RF. Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mol deficiency. Effects of cell activation on Mol/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest 1984; 74:1291- 1300.
  20. Todd RF, Arnaout MA, Rosin RE, Crowley CA, Peters WA, Curnutte JT, Babior BM. The subcellular localization of gp155 (Mol), a glycoprotein associated with neutrophil adhesion. J Clin Invest 1984; 74:1280-1290.
  21. Arnaout  MA,  Dana  N,  Pitt  J,  Todd  RF  III.  Deficiency  of  two  human  leukocyte  surface membrane glycoproteins (Mol and LFA-1). Fed Proc 1985; 44:2664-2670.
  22. Todd RF, Roach JA, Arnaout MA. The modulated expression of Mo5, a human myelomonocytic plasma membrane antigen. Blood 1985; 65:964-973.
  23. Arnaout MA, Hakim RM, Todd RF III, Dana N, Colten HR. The granulocytopenia of hemodialysis is associated with increased surface expression of a granulocyte adhesion promoting glycoprotein (Mol). N Engl J Med 1985; 312:457- 462.
  24. Arnaout  MA,  Hakim  RM,  Todd  RF  III,  Dana  N,  Colten  HR.  The  granulocytopenia  of hemodialysis, a response. N Engl J Med 1985; 312:1578-1579.
  25. Lanier LL, Arnaout MA, Schwarting R, Warner NL, Ross GD. p150/95, Third member of the LFA-1/CR3   polypeptide   family   identified   by   anti-Leu    M5    monoclonal    antibody. Eur J Immunol 1985; 15:713-718.
  26. Arnaout MA, Wang EA, Clark SC, Sieff CA. Human recombinant GM-CSF increases cell-to- cell adhesion and surface expression of adhesion--promoting surface glycoproteins on mature granulocytes. J Clin Invest 1986; 78:597-601.
  27. Pierce MW, Remold-O'Donnell E, Todd RF III, Arnaout MA. N-Terminal sequence of human leukocyte glycoprotein Mo1: Conservation across species and homology to platelet IIb/IIIa. Biochem. Biophysica Acta 1986; 874:368-371.
  28. Dana N, Styrt  B, Griffin  GD, Todd  RF III,  Klempner MS,  Arnaout MA.  Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies. J Immunol 1986; 137:3259:3263.
  29. Dana N, Tenen D, Clayton L, Pierce M, Lachmann P, Arnaout MA. Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta subunit precursor and  beta subunit messenger RNA.  J Clin Invest 1987; 79:1010-1015.
  30. Dana N, Todd RF, Colten HR, Arnaout MA. A dysfunctional Mo1 glycoprotein is present on a subline of the KG1 acute myelogenous  leukemia cell line. J Immunol.  1987; 137:3259-3263.
  31. Dimanche MT, Le Deist F, Fischer A, Arnaout, MA, Griscelli C, Lisowska- Grospierre, B. LFA- 1 β-chain synthesis and degradation in patients with leukocytes adhesive protein deficiency. Eur J Immunol 1987; 17:417-419.
  32. Freyer, D.R., Morganroth, M.L., Rogers, C.E., Arnaout, M.A. and Todd, R.F. Regulation of surface glycoproteins CD11/CD18 (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopath 1987; 46:272-283.
  33. Arnaout, M.A., Remold O’Donnell, E., Pierce, M.W., Harris, P., and Tenen, D.G. Molecular cloning of the human and guinea pig alpha subunit of leukocyte adhesion glycoprotein Mo1: Chromosomal localization and homology to the alpha subunits of Integrins. Proc Natl Acad Sci (USA) 1988; 85:2776-2780.
  34. Arnaout, M.A., Gupta, S.K., Pierce, M.W. and Tenen, D.G. Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (CR3). J Cell Biol 1988; 106:2153-2158.
  35. Arnaout, M.A., Lanier, L.L. and Faller, D.V. Relative contribution of the leukocyte molecules Mo1, LFA-1, p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus- specific. J Cell Physiol 1988; 137:305-309.
  36. Schwartz D, Wong RC, Chatila T, Arnaout A, Miller R, Geha R. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. J Clin Immunol. 1989; Mar; 9(2):151-8.
  37. Rosmarin, A.G., Weil, S., Law, S.K., Griffin, J.D., Arnaout, M.A. and Tenen, D.G. Differential expression of Mo1 and myeloperoxidase genes during myeloid differentiation. Blood 1989; 73:131-136.
  38. Luscinskas, F.W., Brock, A.F., Arnaout, M.A. and Gimbrone, M.A. Endothelial-leukocyte adhesion molecule-1 (ELAM-1)-dependent and leukocyte (CD11/18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine activated human vascular endothelium. J Immunol 1989; 142:2257-2263.
  39. Southwick, F.S., Howard, T.H., Holbrook, T., Anderson, D.C., Stossel, T.P. and Arnaout, M.A. The relationship between CR3 deficiency and neutrophil actin assembly. Blood. 1989; 73:1973- 1979.
  40. Chatila, T., Geha, R.S. and Arnaout, M.A. Constitutive and stimulus-induced phosphorylation of the leukocyte adhesion molecules CD11/CD18. J Cell Biol 1989; 109:2743-2751.
  41. Arnaout, M.A., Dana, N., Gupta, S.K., Tenen, D.G., and Fathallah, D.F. Point mutations impairing cell surface expression of the common b subunit (CD18) in a patient with Leu-CAM deficiency. J Clin Invest 1990; 85: 977-981.
  42. Niles, J.L., McCluskey, R.T., Ahmad, M.F. and Arnaout, M.A. Wegener’s Granulomatosis autoantigen is a novel neutrophil serine proteinase. Blood. 1989; 74:1888-1893.
  43. Lencer, W.I., Verkman, A.S., Arnaout, M.A., Ausiello, D and Brown, D. Endocytic vesicles from renal papilla which cycle the vasopressin-sensitive water channel do not contain an H- ATPase. J Cell Biol 1990; 111: 379-389.
  44. Niles, J.L., Pan, G., Collins, A.B., Shannon, T., Feinberg, R, Arnaout, M.A. and McCluskey, R.T. Value of antigen-specific radioimmunoassays for anti-neutrophil autoantibodies in the diagnosis of rapidly progressive glomerulonephritis. JASN 1991; 2:27-36.
  45. Arnaout, M.A. Auto-antigens in Wegener's Granulomatosis. Blood. 1990; 75:1588-1589.
  46. Niles,  J.L.,  Ahmad,  MF,  McCluskey,  R.T.  and  Arnaout,  M.A.  Specificity  of  Wegener's Granulomatosis autoantibodies. Blood 1990; 75: 2264.
  47. Dana, N., D. M. Fathallah and M. A. Arnaout Expression of a soluble and functional form of the human β2 integrin CD11b/CD18. Proc Natl Acad Sci (USA). 1991; 88:3106-3110.
  48. Gupta, SK, Niles, JL, McCluskey, RT, Arnaout, MA. Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin. Blood. 1990; 76: 2162.
  49. Shelley, CS and Arnaout, MA. The promoter region of the β2 integrin CD11b gene directs myeloid-specific and developmentally regulated expression. Proc Natl Acad Sci (USA). 1991; 88:10525-10529.
  50. Nelson, CE, Rabb, H and Arnaout, MA. Genetic cause of leukocyte adhesion molecule deficiency: Abnormal splicing and a missense mutation in a conserved region of CD18 impair surface expression of β2 integrins. J Biol Chem. 1992; 267:3351-3357.
  51. Toothaker, LE, Gonzalez, DA, Tung N, Lemons, RS, LeBeau, MM, Arnaout, MA, Clayton, LK, Tenen, DG. Cellular myosin heavy chain in human leukocytes: Isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation. Blood. 1991; 78: 1826-1835.
  52. Parkos, CA, Delp, C, Arnaout, MA, and Madara, JL. Neutrophil migration across a cultured intestinal epithelium: Dependence on a CD11b/CD18-mediated event and enhanced efficiency in the physiological direction. J Clin Invest 1991; 88:1605-1612.
  53. Bottinger, E.P., Niles, J.L., Collins, B., McCluskey, R.T. and Arnaout, M.A. MPO-ANCA- positive Wegener's Granulomatosis presenting as Sjogrens Syndrome. Arthritis & Rheum 1992; 35: 1373-1376.
  54. Parkos, CA, Colgan, S.P., Delp, C, Arnaout, MA, and Madara, JL. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J. Cell Biol. 1992; 117: 757-764.
  55. Li, Z-Y, Daniel, E.E., Lane, C.G., Arnaout, M.A. and O'Byrne, P.M. Effect of an anti-Mo1 MAb on  Ozone-induced   airway   inflammation   and   airway   hyperresponsiveness    in    dogs. Am J Physiol. 1992; 263: L723-726.
  56. Maruiwa, M., Russell, G.J., Narula, N., Stronska, M., Rabb, H., Arnaout, M.A. and Bahn, A.K. Anti-KCA-3, a monoclonal antibody reactive with a rat complement receptor, distinguishes Kuppfer cells from other macrophages. J Immunol. 1993; 120: 785-798.
  57. Rabb H, Michishita M, Sharma, CP, Brown D, Arnaout, MA. The Cytoplasmic tails of human Complement Receptor Type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J. Immunol. 1993; 151:990-1002.
  58. Colgan, SP, Parkos, CA, Delp, C, Arnaout, MA and Madara, JL. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-γ in a highly polarized fashion. J. Cell Biol. 1993; 120: 785-798.
  59. Fathallah, DM, Cherif, D., Dellagi, K. and Arnaout, MA. Molecular cloning of a novel hsp70 from a B cell line and its assignment to chromosome 5. J. Immunol. 1993; 121:810-813.
  60. Shelley, CS, Farokhzad, O and Arnaout, MA. Identification of cell-specific and developmentally regulated nuclear factors which direct myeloid and lymphoid expression of the CD11a gene. Proc. Nat'l. Acad. Sci. (USA), 1993; 90:5364-5368.
  61. Michishita, M., Videm, V. and Arnaout, M.A. A novel divalent cation-binding site in the A- domain of the β2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell 1993; 72:857-867.
  62. Böttinger, EP, Shelley, CS Faroukhzad, O and Arnaout, MA. Two cis-acting ets sequences mediate tissue-specific expression of the β2 integrin CD18. Mol. Cell. Biol. 1994; 14:2604- 2615.
  63. Ueda, T., Rieu, P., James Brayer, J., and Arnaout, M.A. Identification of the complement iC3b binding site in the β2 integrin CR3 (CD11b/CD18). Proc. Nat'l. Acad. Sci. (USA), 1994; 91:10680-10684.
  64. Rieu, P., Ueda, T., Haruta, I., Sharma, C.P. and Arnaout, M.A. The A-domain of β2 integrin CR3 (CD11b/CD18) is a receptor for the Hookworm-derived neutrophil adhesion  inhibitor NIF. J. Cell Biol. 1994; 127:2081-2091.
  65. Choi, C., Rabb, H, Arnaout, MA and Ehrlich, P. Preventing the infiltration of leukocytes by monoclonal  antibody  blocks  the  development  of  progressive  ischemia  in  rat  burns. Plastic & Reconstr. Surgery. 1995; 96:1177-1185.
  66. Sharma, CP, Ezzell, R. M.  and Arnaout, MA. Direct interaction of filamin (ABP-280) with the β2 integrin subunit CD18. J. Immunol. 1995; 154:3461-3470.
  67. Daouk, GD, Palsson, R. and Arnaout, MA. 1995. Inhibition of proteinase 3 by ANCA and its correlation with diseases activity in Wegener's       Granulomatosis. Kidney International. 1995; 47:1528-1536.
  68. Lee, J.-O., Rieu, P. Arnaout, M.A. (the corresponding author), and Liddington, R. Crystal Structure of the A-Domain from the α-subunit of Integrin CR3 (CD11b/CD18). Cell, 1995; 80:631-638.
  69. Xie, J., Li, R., Kotovuori, P., Vermont-Desroches, C., Wijdenes, J., Arnaout, M.A., Nortamo, P, Gahmberg, C.G. Intercellular adhesion molecule 2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J. Immunol. 1995; 155: 3619-3628.
  70. Lee, J-O, Arnaout, M. A. (co-corresponding author), and Liddington, R. Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure, 1995; 3:1333-1340.
  71. Rieu, P., Sugimori, T., Griffith, D.L. Arnaout, M.A. Solvent Accessible Residues on the MIDAS face of Integrin CR3 mediate its binding to the Neutrophil Adhesion Inhibitor NIF. J. Biol. Chem. 1996; 271:15858-15861.
  72. Palsson, R., Sharma, C.P., Kim, K., McLaughlin, M., Brown, D. and Arnaout, M.A. Characterization and Cell Distribution of Polycystin 1, the Product of Autosomal Dominant Polycystic Kidney Disease Gene 1. Molecular Medicine. 1996; 2:702-711.
  73. Farokhzad, O., Shelley, C.S., and Arnaout, M.A. Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2. J. Immunol. 1996; 157:5597-5605.
  74. Coxon, A., Rieu, P., Barkalow, F., Phillipe Rieu, Askari, S., von-Andrian, U., Sharpe, A., Arnaout, M.A., Mayadas, T. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation. Immunity. 1996; 5: 653-666.
  75. Ingalles, R., Arnaout, M.A. and Golenbock, D. Outside-in signaling through a tailless integrin. J. Immunol. 1997; 159:433-438.
  76. Shelley, C.S., Da Silva, N., Georgakis, A., Chomienne C. and Arnaout, M.A. 1997.Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. Genomics. 1998; Apr 15; 49(2):334-6.
  77. Li R, Rieu P, Griffith DL, Scott D, Arnaout MA. Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures. J Cell Biol. 1998; 14; 143(6): 1523-34
  78. Goldmann, W.H., Niles, J.L., and Arnaout, M.A. 1999. Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers. Eur. J. Biochemistry. 1999; 261:155-162.
  79. Kim, K., Drummond, I., Ibraghimov-Beskrovnaya1, O., Klinger, K., Arnaout, M. A. 2000.Polycystin 1 is required for the Structural Integrity of Blood Vessels. Proc. Natl Acad. Sci. USA. 2000; 97; 1731-1736.
  80. Farokhzad, O C, Teodoridis, J M, Park, H, Arnaout, MA, and Shelley CS. 2000. CD43 gene expression is mediated by a nuclear factor, which binds pyrimidine-rich single-stranded DNA. Nucleic Acids Res. 2000; 28: 2256-2267.
  81. Xiong J-P, Li R, Essafi M, Stehle T, and Arnaout, MA. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J. Biol. Chem. 2000; Dec 8; 275(49): 38762-7. (Accelerated Publication). Electronic Pub. Date Oct. 16
  82. González-Perrett S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA (Corresp. Author) and Horacio F. Cantiello Polycystin-2, the Protein Mutated in Autosomal Dominant Polycystic Kidney Disease (ADPKD), is a Ca2+-Permeable Non-Selective Cation Channel. Proc. Natl Acad. Sci. USA. 2001; 98(3): 1182-1187.36
  83. Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000; Oct 15; 165(8): 4272-80.
  84. Xiong, J.P., Stehle, S., Diefenbach, B., Zhang, R., Dunker, R., Scott, D.L., Joachimiak, A., Goodman, S.L., and Arnaout, M.A. Crystal Structure of the Extracellular Segment of Integrin αVβ3. Science. 2001; 12; 294(5541): 339-45. Declared one of the top 10 papers in biology in 2001.
  85. Xu GM, Sikaneta T, Sullivan BM, Zhang Q, Andreucci M, Stehle T, Drummond I, Arnaout MA. Polycystin-1 interacts with intermediate filaments. J Biol Chem. 2001; Oct 1 [epub ahead of print]. 276: 46544-46552.
  86. Li R, Haruta, I, Rieu, P, Xiong, J-P, and Arnaout MA. A Monoclonal Antibody to the MIDAS face of Integrin CD11b is a mimic of the activation-independent ligand NIF. 2002; J. Immunol, 168:1219-25.
  87. Xu, GM and Arnaout, MA. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with Splicing Factor SC35. Genomics. 2002; Jan; 79(1): 87-94.
  88. Rabb H, Chandran PK, Arnaout MA, Kehrli ME Jr. Use of a bovine model to study the role of adhesion molecule CD11/CD18 in hemodialysis-induced neutropenia. Am J Kidney Dis. 2002; Mar; 39 (3): 587-93.
  89. Arnaout, MA. Opportunities and Challenges of sustainable development in the Arab World. ESCWA  Forum  on  Technology,  Employment  and  Poverty  Alleviation.  United  Nations Forums. July 2002.
  90. Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Bottinger EP, Arnaout MA. During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol. 2002; Apr 15; 168(8): 3887-93.
  91. Xiong, J.P., Stehle, Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., and Arnaout, M.A. Crystal Structure of the Extracellular Domain of Integrin αVβ3 in complex with an Arg-Gly-Asp ligand. Science. 2002; Apr 5; 296(5565): 151-155. (Published online ahead of print on March 7,2002).
  92. Alonso, J.L., Essafi, M., Xiong, J-P., Stehle, T., and Arnaout, M.A. 2002. Does the integrin αA domain act as a ligand for its bA domain? Current Biology. 2002; May 14; 12(10): R340-2.
  93. González-Perrett, S, Batelli, M, Kim, K, Reisin, IL, Arnaout, MA and Cantiello, HF. Regulation by pH of Human Polycystin-2 Mediated Cation Channel Activity. J Biol Chem. 2002; May 3 [epub ahead of print].
  94. Xu G.M., González-Perrett, S, Essafi, M, Timpanaro, GA, Montalbetti, N., Arnaout, M.A. (corresp. Author) and Cantiello, H. F. Polycystin-1 Regulates Polycystin-2 Channel Function. J Biol Chem. 2002; Oct 28. [PubMed - as supplied by publisher].
  95. Park, H., Shelley, C. S. and Arnaout, M. A. The zinc finger transcription factor ZBP-89 is a repressor of the human β2 integrin CD11b gene. Blood, 2003; 101, 894-902
  96. Nicolaou, F, Teodoridis, JM, Park, H, Georgalis A, Farokhzad OC, Bottinger E, Da Silva, N, Rousselot, P, Chomienne, C, Ferenczi, K, Arnaout, MA and Shelley, C.S. CD11c gene expression in hairy cell leukemia is dependent upon activity of the protooncognes ras and Jun D. Blood. 2003; [epub ahead of print].
  97. Ajroud K, Sugimori T, Goldmann WH, Fathallah DF, Xiong JP, Arnaout MA. Binding affinity of metal  ions  to  the  CD11b  A-domain  is  regulated  by  integrin  activation  and  ligand. J Biol Chem. 2004; Apr 7 [Epub ahead of print].
  98. Xiong JP, Stehle T, Goodman SL, Arnaout MA. A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem. 2004; Aug 6 (accelerated publication). [Epub ahead of print].
  99. Adair, B, Xiong, J-P, Maddock, C, Goodman, SL, Arnaout, MA (corresp. Author) and Mark Yeager. EM  structure  of  the  ectodomain  of  integrin  αVβ3  in  complex  with  fibronectin. J Cell Biol. 2005; 168:1109-1118.
  100. Devchand, P.R., Birgitta A. Schmidt, B.A., Primo, V.C., Arnaout, M.A., Serhan, C.N. and Nikolic, B. A synthetic eicosanoid mimetic unravels host-donor interactions in allogeneic BMT- induced GvHD to reveal an early protective role for host neutrophils. FASEB J. 2005; Feb; 19(2): 203-10.
  101. Ding, Z., Bradley, K.A., Arnaout, M.A., Xiong, J-P. Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. 2006. Protein Expression and Purification. 2006; September; 49:121-128.
  102. Li, X., Shelley, C.S., Xiong, J-W and Arnaout, M.A. The ZBP-89 gene specifies hematopoietic stem cell development from FLK1+ mesoderm. 2006; Development. Sep; 133(18): 3641-50. Epub 2006 Aug 16.
  103. Zerria K, Jerbi E, Hammami S, Boubaker S, Xiong J-P, Dellagi K, Arnaout MA and Fathallah, DM. Recombinant Integrin CD11b A-domain Protects against Skeletal Muscle Inflammatory Injury in the Rat. 2006. Immunology. 2006; Dec; 119 (4): 431-40. Epub 2006 Oct 9.
  104. Gupta V, Lindroos A, Sugimori T, Ianakiev P, Xiong JP and Arnaout MA. The b-tail domain (βTD) regulates physiologic ligand binding to integrin CD11b/CD18. 2006. Blood; Apr 15; 109(8): 3513-20. Epub 2006 Dec 14.
  105. Steele, DJR, Hamilton, E, and Arnaout, MA. A Case Management Model to Improve Hemodialysis Outpatient Outcomes. Hemodialysis International. 2007; 11(2): 247-51.
  106. Park, JY, Arnaout, MA, and Vineet Gupta, V. A simple, no-wash cell-adhesion based high throughput assay for the discovery of small molecule regulators of the integrin CD11b/CD18. Journal of Biomolecular Screening. 2007; Apr12 (3): 406-17.
  107. Gupta V, Alonso, JL, Sugimori, T, Xiong, JP and Arnaout MA. Role of the b-Subunit Arginine/Lysine Finger in Integrin Heterodimer Formation and Function. J Immunol. 2007; 180:1713-8.
  108. Xiong, J-P., Mahalingham, B., Alonso, J.L., Borrelli, L.A., Rui, X., Anand, S., Hyman, B. T., Rysiok, T., Müller-Pompalla, D., Goodman, S.L., and Arnaout, M.A. Crystal structure of integrin αVβ3 inclusive of a transmembrane fragment defines the b-genu and depicts an orientation of the ectodomain in a lipid bilayer. J Cell Biol. 2009; I186: 589-600.
  109. Primo, VC, Marusic, S., Franklin CC, Goldmann, WH, Achaval, CG, Smith, RN, Arnaout, MA, Nikolic, B. "Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis. Clinical & Exp. Immunol. 2009; 159:327-337. PMCID: PMC2819498
  110. Levy, B.D., Qing-yin Zhang, Q-Y, Caroline Bonnans, C., Primo, V., Reilly, J.J., Perkins, D.L. Arnaout, M.A., Boris Nikolic, B., and Serhan, C.N. 2011. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 reduce neutrophil activation during allograft rejection to preserve organ function. Prostaglandins, Leukotrienes and Essential Fatty Acids 2010; 84: 43-50. Published online September 24. PMCID: PMC3019284
  111. Mahalingam, B., Ajroud, K., Alonso, J.L., Anand, S., Adair, B., Horenstein, A.L., Malavasi, F., Xiong, J-P., and Arnaout, M.A. Stable coordination of the inhibitory Ca2+ ion at the metal-ion- dependent-adhesion site in integrin CD11b/CD18 by antibody-derived ligand aspartate: Implications for integrin regulation and structure-based drug design. J. Immunol. 2011; 187(12): 6393-401. PMCID: PMC3237904
  112. Adair, B, Xiong, JP, Alonso, J-L, Hyman, BT, and Arnaout MA. 2013. EM Structure of the Ectodomain of Integrin CD11b/CD18 and Localization of its Ligand-binding Site Relative to the Plasma Membrane. PLoS ONE 2013; 8(2): e57951. doi:10.1371/journal.pone.0057951.
  113. Frohlich, E, Alonso, JL, Borenstein, JT, Arnaout, MA and Charest, J. 2013. Topographically patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers. Lab-On-Chip. 2013; DOI: 10.1039/c3lc50199j
  114. Yu, C-C, Fornoni, A, Harkoush, S, Maiguel, D, Sageshima, J, Chen, L, Ciancio, G, Faridi, MH, Behr, D, Campbell, KN, Chang, J-M, Chen, H-C, Oh, J, Faul, C, Arnaout, MA, Fiorina, P, Gupta, V, Burke, G, Mundel, P. 2013. Abatacept is a novel anti-proteinuric treatment that stabilizes kidney podocyte function. N Engl J Med. 2013; 369(25): 2416-23.
  115. Li, X, Romain, R, Park, D, Scadden, DT, Merchant, JL, and Arnaout, MA. 2013. Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Stem Cells. 2014; Mar; 32(3): 791-801. (Featured in Hematopoiesis News 4.44 November 12, 2013)
  116. Adair, B, Altintas, MA, Clemens C. Möller, CC, Arnaout, MA (Co-senior Author), Reiser, J. Structure of the Kidney Slit Diaphragm Adapter Protein CD2-Associated Protein as Determined with Electron Microscopy. J Am Soc Nephrol. 2014; Jul; 25(7): 1465-1473. Epub 2014 Feb 7.
  117. Van Agthoven, JF, Xiong, JP, Alonso, JL, Rui, X, Adair, BD, Goodman, SL, Arnaout MA. Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin. Nature Struc Mol Biol. 2014; Apr; 21(4): 383-8. doi: 10.1038/nsmb.2797. Epub 2014 Mar 23.
  118. Mahalingam, B, Van Agthoven, J, Xiong J-P, Alonso, JL, Adair, BD, Rui, X, Anand, S, Burger, C, Goodman, SL, Arnaout, MA. Atomic basis for the species-specific inhibition of αV integrins by mAb 17E6 is revealed by the crystal structure of the integrin αVβ3 ectodomain-17E6 complex. J. Biol Chem. 2014; Apr 1. [Epub ahead of print].
  119. Rui, X, Mehrbod, M, Van Agthoven, JF, Xiong J-P, Mofrad, MRK, Arnaout, MA. The α-subunit regulates stability of the metal ion at the ligand-associated metal binding site in β3 integrins. J Biol Chem. 2014; Jun 28. pii: jbc.M114.581470. [Epub ahead of print].
  120. Palmire, A, Lee, J, Ryklin, G, Camarata, T, Selig, MK, Duchemin, A-L, Nowak, P, Arnaout, MA, Drummond, I, Vasilyev, A. Collective epithelial migration drives kidney repair after acute injury. PLoS ONE. 2014; Jul 10; 9(7): e101304. Doi: 10.1371/journal.pone.0101304.
  121. Zhang, J, Wu, Q, Koh, W, Yu, Q, Zhu, X, Amsterdam, A, Davis, GE, Arnaout, MA, and Xiong, J-W. 2014. Itgβ1 and Tln1 regulate cardiovascular lumen maintenance and angiogenesis. Submitted.
  122. Zhang, J, Yuan, S., Vasilyev, A, Arnaout, MA. 2014. The transcriptional coactivator Taz regulates proximodistal patterning and morphogenesis of the pronephric tubule in zebrafish Submitted.
  123. Camarata, T, Weaver, G, Vasilyev, A, Arnaout, MA. 2014. Stem cell antigen-1 (Sca-1) is expressed in kidney epithelium and protects the adult mouse kidney from ischemia-reperfusion injury through downregulation of the TGFb pathway. Submitted.
  124. Adair, B, Al-Rahman, M, Anand, S, Mathew, S, Zent, R, Sanders, CR, Arnaout, MA. 2014.Genetic and structural evidence for a  second α/β transmembrane interface in β3 integrins. In preparation.
  125. Xiong, J-P, Scott, DL, Sugimori, T, Coller, BS and Arnaout, MA. 2014. Three-dimensional Structure of the Chimeric Fab c7E3 (Abciximab/ReoProâ); A Clinically Effective Platelet αIIbβ3 Integrin Antagonist. In preparation.
  126. Frohlich, EM, Hyoungshin Park, H, Jose Luis Alonso, JL, Arnaout MA, Charest, JL. 2014. A microphysiological model of the renal proximal tubule demonstrates reabsorptive function. In preparation.

Non-peer reviewed scientific or medical publications/materials in print or other media

Book Chapters:

  1. Arnaout, MA, Rennke, H, Cotran, RS. 1982. Membranous glomerulonephritis. In: Brenner BM,  Stein  J,  Eds.                            Contemporary  Issues in  Nephrology.     Vol. 9, New York: Churchill Livingstone, 199-235.
  2. Arnaout, MA, Colten HR. 1984.     Complement C3 receptors, structure and function.    Mol Immunol; 21:1191-1199.
  3. Todd, RF, Arnaout, MA. 1985. Monoclonal antibodies that identify Mol and LFA-1, two human leukocyte membrane glycoproteins: A review In: Second International Workshop on human leukocyte differentiation antigens. Schlossman SF, Reinherz EL, ed., Vol. 3; 95-108.
  4. Dana,  N.,  Todd,  RF.,  III,  Arnaout,  MA.     1986. The Mo1 surface glycoprotein: Structure, Function and Clinical Importance. Pathol Immunopath Research; 5: 371-381.
  5. Arnaout, MA, Pierce, M, Dana, N, Clayton, LK. 1987. Complement receptor type 3 (CR3): structure and function. Methods in Enzymology, DiSabato G, Langone JJ, Van Vanakis H, Eds. Acad Press Inc., Fl.; 150: 602- 615.
  6. Arnaout, MA. 1987. Structure and function of a family of leukocyte adhesion molecules (Leu- CAM) involved in T-cell killing and complement mediated phagocytosis. In: Handbook of Cytolytic lymphocyte clones and complement as effectors of the immune system. Podak ER, ed., CRC-Press Inc., NY; 1: 109-126.
  7. Dana, N. and Arnaout, M.A. 1988. Leukocyte adhesion molecule deficiency. In  Complement and Immunologic disease, Baillere's Clinical Immunology and Allergy, M. Kazatchkine, Ed.,W.B. Saunders Co., London. 1988; 2: 453-476.
  8. Arnaout, M.A. 1990. Structure and function of the Leukocyte Adhesion Molecules CD11/CD18. Blood 75: 1037-1050
  9. Arnaout, M.A. 1990. Leukocyte Adhesion Molecule Deficiency: Its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev. 14: 145-180.
  10. Dana, N. and Arnaout, M.A. 1990. Leukocyte adhesion molecule deficiency. Current Opinions in Pediatrics. DG Nathan, Ed. 2: 916-919.
  11. Dana, N., Fathallah, D.M. and Arnaout, M.A. 1991. Function of a soluble β2 integrin CD11b/CD18. In Structure, Function and Regulation of Molecules involved in leukocyte adhesion. Lipsky, PE, Rothlein, R., Kishimoto, TK, Faanes, RB, Smith, CW, Eds. Springer- Verlag, New York, Publishers. pp34-44.
  12. Arnaout, M.A., Michishita, M. & Sharma, C.P. 1992. On the regulation of β2 integrins. In Lymphocyte activation and immune regulation IV: Cellular Communications. Gupta, S, Paul, W. Eds. Plenum Publishing Corp. NY. 171-180.
  13. Shelley, CS, Böttinger, EP and Arnaout, MA. 1992. Transcriptional regulation of β2 integrins. In Leukocyte adhesion, basic and clinical aspects. Novo Nordisk Fndn symposium No 6. Elsevier Sci. Publ. B.V. The Netherlands. 337-351.
  14. Arnaout, M.A. and Newberger, P.E. 1993. Leukocyte Adhesion Molecule Deficiency and Chronic Granulomatous Disease. In: Clinical aspects of Immunology, PJ Lachmann, DK Peters, FS Rosen, MJ Walport Eds. 1305-1324. Blackwell Scientific Publications.
  15. Arnaout, M.A. Cell Adhesion Molecules. 1993. Textbook of Rheumatology. Forth Edition. William Kelley, ED Harris, S Ruddy, CB Sledge, Eds. WB Saunders Co. Publishers. 213-226.
  16. Arnaout, M.A. Molecular basis for Leukocyte adhesion deficiency. 1993. In "Biochemistry of macrophages and related cell types". M. Horton, Ed. 335-346. Plenum Press, NY.
  17. Arnaout, M.A. 1993. Cell adhesion molecules in inflammation and thrombosis: Status and prospects. Am. J. Kid. Ds. 121: 72-76.
  18. Arnaout, M.A., Michishita, M. 1993. Genetic abnormalities in Leukocyte adhesion molecule deficiency. In, New Concepts in immunodeficiency diseases. Gupta, S. and Griscelli, C. Eds. 191-202. John Wiley & Sons, Publishers.
  19. Arnaout, M.A. 1993. The dynamics and regulation of leukocyte-endothelial cell interactions. In Current Opinions in Hematology, 1: 113-122
  20. Dana, N. and Arnaout, M.A. 1994. The role of β2 integrins in leukocyte adhesion.  In Integrins: The Biological problems. Takada, Y, Ed. CRC Press; pp37-54.
  21. Arnaout, M.A. Structure and regulation of Cell Adhesion Molecules 1994. In Samter's Immunologic Diseases. Frank, MM, Austen, KF, Claman, HN and Unanue, ER, Eds. pp.: 161- 182.
  22. Rieu, P. and Arnaout, M.A. 1996. β2 integrins: Key effectors of the inflammation. In Adhesion Molecules & the Lung. P. Ward, Ed.; 89: 1-42. Pub. Marcel Dekker, Inc.
  23. Arnaout, M.A. 1996. Structural diversity of Cell Adhesion Molecules and their Role in Inflammation. Textbook of Rheumatology. Fifth Edition. William Kelley, ED Harris, S Ruddy, CB Sledge, Eds. WB Saunders Co. Publishers. 303-322.
  24. Kanazachi, S-I, Sharma, P. and Arnaout, M.A. 1997. Integrin-ligand interactions: scratching the surface. In Current Opinions in Hematology. 4:67-74.
  25. Sugimori, T., Griffith, D. and Arnaout, M.A. 1997. Emerging paradigms of integrin-ligand interactions. Kidney International(suppl.) 51:1454-1462.
  26. Hogg, N and Arnaout, M.A. 1997. CD11b. In Protein Reviews on the Web.
  27. Arnaout, M.A. 1998. Mechanisms of Leukocyte Extravasation. In Textbook of Molecular Medicine. Jamison, LJ, Ed. Blackwell Scientific Publications. pp 641-649.
  28. Li, R. and Arnaout, M.A. Functional assays for β2  integrins. 1999. In ethods Mol Bio
  29. Arnaout, M. A. 2000. The vasculopathy of autosomal dominant polycystic kidney disease: Insights from animal models. Kidney International, Dec; 58(6): 2599-610.
  30. Arnaout, M. A. 2001. Molecular Genetics and Pathogenesis of Autosomal Dominant Polycystic Kidney Disease. Ann. Rev. Med. 52, 93-123.
  31. Arnaout, M. A., Goodman, S and Xiong, J-P. 2002. Coming to grips with integrin binding to ligands. In Cell-to-cell contact and extracellular matrix, Current Opinion in Cell Biology. Ken Yamada and Rolf Kemler, section Editors. Vol. 14, Issue 5. Oct; 14(5): 641-51.
  32. Arnaout, M. A. 2002. Integrin Structure: New twists and turns in dynamic cell adhesion. In Adhesion in the Immune System. Yoji Shimizu, section editor. Immunological Reviews. 2002. Aug; 186:125-40.
  33. Seow, K-T, Xiong, J-P, Arnaout, MA. 2002. Welge, J., Rippmann, F. and Goodman, S.L. 2002.Biochem. Pharmacology, 7296: 1-8.
  34. Xiong JP, Stehle T, Goodman SL, Arnaout MA. 2003. New insights into the structural basis of integrin activation. Blood. 102:1155-1159.
  35. Arnaout     MA.    2003.    Autosomal    Dominant    Polycystic    Kidney    Disease.    In    Nature’s Encyclopedia of the Human Genome. Editor, Cooper D. Nature Publishing Group. Macmillan Publishers Ltd.
  36. Arnaout, MA. 2004. Cystic Kidney Diseases. In Cecil’s Textbook of Medicine. 22nd  edition. Pages 767-772. Sauders Publishers.
  37. Xiong, J-P, Goodman, S, Stehle, T and Arnaout, MA. 2003. Integrins, cations and ligands: making the connection. J. Thrombosis and Haemostasis. Vol. 1(7), 1642-1654. (Online publication date: 20-Jun-2003.)
  38. Arnaout, MA, Mahalingam, B., Xiong, J-P. 2005. Integrin structure, allostery and bidirectional signaling. Ann Rev Cell Biol. 21:381-410.
  39. Arnaout, MA. 2007. Cystic Kidney Diseases. In Cecil’s Textbook of Medicine. 23nd edition.
  40. Xiong, J-P, Goodman, SL and Arnaout, MA. Purification, analysis and crystal structure of integrins. 2007. In Methods in Enzymology. DA Cheresh, Editor. Vol 426: 307-336.
  41. Arnaout, MA, Goodman, SL, and Xiong, J-P. Structure and mechanics of integrin-based cell adhesion. 2007. Current Opinion in Cell Biology. 19: 495–507.
  42. Arnaout, MA. Integrin b2 subunit. 2009. UCSD Nature Molecule. The Signaling Gateway. Nature Publishing Group. Published online: 22 Dec 2009 | doi: 10.1038/mp.a001213.01. URL: http://www.signaling-gateway.org/molecule/query?       afcsid=A001213&type=molpage
  43. Arnaout, MA. 2010. Cystic Kidney Diseases. In Cecil’s Textbook of Medicine. 24nd edition.
  44. Arnaout, MA. 2010. Autosomal Dominant Polycystic Kidney Disease. In Encyclopedia of the Life    Sciences.  September     15, John  Wiley & Sons,Ltd, UK.DOI:10.1002/ 9780470015902.a0006010.pub2
  45. Arnaout, MA. 2014. Cystic Kidney Diseases. In Cecil’s Textbook of Medicine. 25nd edition. In press.
  46. Arnaout, MA. 2015. Integrims in stem cells. Invited review. Stem Cells. In preparation.

M. Amin Arnaout

Professor

 

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