• Ratner V, Sosunov SA, Niatsetskaya ZV, Utkina-Sosunova IV, Ten VS. Mechanical  ventilation causes pulmonary mitochondrial dysfunction and delayed alveolarization in neonatal mice. Am J Respir Cell Mol Biol. 2013 Dec;49(6):943-50. doi: 10.1165/rcmb.2012-0172OC. PubMed PMID: 23980609; PubMed Central PMCID: PMC3931106.
  • Utkina-Sosunova IV, Niatsetskaya ZV, Sosunov SA, Ratner VI, Matsiukevich D,Ten VS. Nelfinavir inhibits intra-mitochondrial calcium influx and protects brainagainst hypoxic-ischemic injury in neonatal mice. PLoS One. 2013 Apr 22;8(4):e62448. doi: 10.1371/journal.pone.0062448. Print 2013. PubMed PMID: 23614049; PubMed Central PMCID: PMC3632564.


  • Williams JJ, Mayurasakorn K, Vannucci SJ, Mastropietro C, Bazan NG, Ten VS, Deckelbaum RJ. N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. PLoS One. 2013;8(2):e56233. doi: 10.1371/journal.pone.0056233. Epub 2013 Feb 20. PubMed PMID: 23437099; PubMed Central PMCID: PMC3577805.
  • Ten VS, Starkov A. Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria. Neurol Res Int. 2012;2012:542976. doi:  0.1155/2012/542976. Epub 2012 Mar 22. PubMed PMID: 22548167; PubMed Central PMCID: PMC3323863.
  • Niatsetskaya ZV, Sosunov SA, Matsiukevich D, Utkina-Sosunova IV, Ratner VI, Starkov AA, Ten VS. The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. J Neurosci. 2012 Feb 29;32(9):3235-44. doi: 10.1523/JNEUROSCI.6303-11.2012. PubMed PMID: 22378894; PubMed Central PMCID: PMC3296485.
  • Niatsetskaya ZV, Charlagorla P, Matsukevich DA, Sosunov SA, Mayurasakorn K, Ratner VI, Polin RA, Starkov AA, Ten VS. Mild hypoxemia during initial reperfusion alleviates the severity of secondary energy failure and protects brain in neonatal mice with hypoxic-ischemic injury. J Cereb Blood Flow Metab. 2012 Feb;32(2):232-41. doi: 10.1038/jcbfm.2011.164. Epub 2011 Nov 23. PubMed PMID: 22108720; PubMed Central PMCID: PMC3272612.
  • Wang X, Leverin AL, Han W, Zhu C, Johansson BR, Jacotot E, Ten VS, Sims NR, Hagberg H. Isolation of brain mitochondria from neonatal mice. J Neurochem. 2011  Dec;119(6):1253-61. doi: 10.1111/j.1471-4159.2011.07525.x. Epub 2011 Nov 3. PubMed PMID: 21985402; PubMed Central PMCID: PMC3532608.
  • Rowlands DJ, Islam MN, Das SR, Huertas A, Quadri SK, Horiuchi K, Inamdar N, Emin MT, Lindert J, Ten VS, Bhattacharya S, Bhattacharya J. Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels. J Clin Invest. 2011 May;121(5):1986-99. doi: 10.1172/JCI43839. Epub 2011 Apr 25. PubMed PMID: 21519143; PubMed Central PMCID:  PMC3083796.
  • Mayurasakorn K, Williams JJ, Ten VS, Deckelbaum RJ. Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. Curr Opin Clin Nutr Metab Care. 2011 Mar;14(2):158-67. doi: 10. 1097/MCO.0b013e328342cba5. Review. PubMed PMID: 21178607.
  • Ten VS, Yao J, Ratner V, Sosunov S, Fraser DA, Botto M, Sivasankar B, Morgan  BP, Silverstein S, Stark R, Polin R, Vannucci SJ, Pinsky D, Starkov AA. Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury. J Neurosci. 2010 Feb 10;30(6):2077-87. doi: 10.1523/JNEUROSCI.5249-09.2010. Erratum in: J Neurosci. 2014 Jan 1;34(1):339. PubMed PMID: 20147536; PubMed Central PMCID: PMC2821109.
  • Matsiukevich D, Randis TM, Utkina-Sosunova I, Polin RA, Ten VS. The state of  systemic circulation, collapsed or preserved defines the need for hyperoxic or normoxic resuscitation in neonatal mice with hypoxia-ischemia. Resuscitation. 2010 Feb;81(2):224-9. doi:  0.1016/j.resuscitation.2009.11.024. Epub 2009 Dec 31. PubMed PMID: 20045241; PubMed Central PMCID: PMC2814885.
  • Ten VS, Matsiukevich D. Room air or 100% oxygen for resuscitation of infants  with perinatal depression. Curr Opin Pediatr. 2009 Apr;21(2):188-93. doi: 10.1097/MOP.0b013e32832925b8. Review. PubMed PMID: 19300260. 13: Ratner V, Starkov A, Matsiukevich D, Polin RA, Ten VS. Mitochondrial dysfunction contributes to alveolar developmental arrest in hyperoxia-exposed mice. Am J Respir Cell Mol Biol. 2009 May;40(5):511-8. doi: 10.1165/rcmb.2008-0341RC. Epub 2009 Jan 23. PubMed PMID: 19168698; PubMed Central PMCID: PMC3269235.
  • Ratner V, Slinko S, Utkina-Sosunova I, Starkov A, Polin RA, Ten VS. Hypoxic stress exacerbates hyperoxia-induced lung injury in a neonatal mouse model of bronchopulmonary dysplasia. Neonatology. 2009;95(4):299-305. doi: 10.1159/000178798. Epub 2008 Dec 4. PubMed PMID: 19052476; PubMed Central PMCID:  PMC3659784.
  • Bianco-Batlles MD, Sosunov A, Polin RA, Ten VS. Systemic inflammation following hind-limb ischemia-reperfusion affects brain in neonatal mice. Dev Neurosci. 2008;30(6):367-73. doi: 10.1159/000164686. Epub 2008 Oct 15. PubMed PMID: 18854644; PubMed Central PMCID: PMC2629657.
  • Caspersen CS, Sosunov A, Utkina-Sosunova I, Ratner VI, Starkov AA, Ten VS. An isolation method for assessment of brain mitochondria function in neonatal mice with hypoxic-ischemic brain injury. Dev Neurosci. 2008;30(5):319-24. doi: 10.1159/000121416. Epub 2008 Mar 19. PubMed PMID: 18349523; PubMed Central PMCID:PMC2890306.
  • Ratner V, Kishkurno SV, Slinko SK, Sosunov SA, Sosun ov AA, Polin RA, Ten VS.  The contribution of intermittent hypoxemia to late neurological handicap in mice  with hyperoxia-induced lung injury. Neonatology. 2007;92(1):50-8. Epub 2007 Feb PubMed PMID: 17596736.
  •  Slinko S, Caspersen C, Ratner V, Kim JJ, Alexandrov P, Polin R, Ten VS.Systemic hyperthermia induces ischemic brain injury in neonatal mice with ligated carotid artery and jugular vein. Pediatr Res. 2007 Jul;62(1):65-70. PubMed PMID: 17515843.
  • Presti AL, Kishkurno SV, Slinko SK, Randis TM, Ratner VI, Polin RA, Ten VS. Reoxygenation with 100% oxygen versus room air: late neuroanatomical and neurofunctional outcome in neonatal mice with hypoxic-ischemic brain injury. Pediatr Res. 2006 Jul;60(1):55-9. Epub 2006 May 11. PubMed PMID: 16690944.
  • Mack WJ, Sughrue ME, Ducruet AF, Mocco J, Sosunov SA, Hassid BG, Silverberg JZ, Ten VS, Pinsky DJ, Connolly ES Jr. Temporal pattern of C1q deposition after transient focal cerebral ischemia. J Neurosci Res. 2006 Apr;83(5):883-9. PubMed PMID: 16447284.
  • Ten VS, Sosunov SA, Mazer SP, Stark RI, Caspersen C, Sughrue ME, Botto M Connolly ES Jr, Pinsky DJ. C1q-deficiency is neuroprotective against hypoxic-ischemic brain injury in neonatal mice. Stroke. 2005 Oct;36(10):2244-50. Epub 2005 Sep PubMed PMID: 16179576.
  • Ten VS, Wu EX, Tang H, Bradley-Moore M, Fedarau MV, Ratner VI, Stark RI, Gingrich JA, Pinsky DJ. Late measures of brain injury after neonatalhypoxia-ischemia in mice. Stroke. 2004 Sep;35(9):2183-8. Epub 2004 Jul 22. PubMed PMID: 15272130.
  • Ten VS, Bradley-Moore M, Gingrich JA, Stark RI, Pinsky DJ. Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy. Behav Brain Res. 2003 Oct 17;145(1-2):209-19. PubMed PMID: 14529818.
  • Ten VS, Pinsky DJ. Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care. 2002 Jun;8(3):242-50. Review. PubMed PMID: 12386504.Ten VS, Mazur LI, Nikolaychik VV, Moiseev AN. [Disorders of protein metabolism in neonatal hyperbilirubinemia and their correction by extracorporeal  detoxification]. Pediatriia. 1989;(6): 29-33. Russian. PubMed PMID: 2762050.

Vadim Ten

Associate Professor


  • : 212-342-0075

  • DEPARTMENTDepartment of Pediatrics
    Columbia University