Publications

  1. Huang C, Shen S, Ma Q, Gill A, Pollock CA, Chen XM. KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 Feb;29(2):313-24. PubMed PMID: 24166472. Pubmed Central PMCID: 3910344.
  2. Huang C, Pollock CA, Chen XM. Role of the potassium channel KCa3.1 in diabetic nephropathy. Clinical science. 2014 Oct;127(7):423-33. PubMed PMID: 24963668.
  3. Huang C, Pollock CA, Chen XM. High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel. PloS one. 2014;9(4):e95173. PubMed PMID: 24733189. Pubmed Central PMCID: 3986377.
  4. Huang C, Lin MZ, Cheng D, Braet F, Pollock CA, Chen XM. Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux. Laboratory investigation; a journal of technical methods and pathology. 2014 Mar;94(3):309-20. PubMed PMID: 24492284.
  5. Huang C, Day ML, Poronnik P, Pollock CA, Chen XM. Inhibition of KCa3.1 suppresses TGF-beta1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways. The international journal of biochemistry & cell biology. 2014 Feb;47:1-10. PubMed PMID: 24291552.
  6. Yong R, Chen XM, Shen S, Vijayaraj S, Ma Q, Pollock CA, et al. Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling. PloS one. 2013;8(8):e73428. PubMed PMID: 23991195. Pubmed Central PMCID: 3753271.
  7. Tang O, Chen XM, Shen S, Hahn M, Pollock CA. MiRNA-200b represses transforming growth factor-beta1-induced EMT and fibronectin expression in kidney proximal tubular cells. American journal of physiology Renal physiology. 2013 May 15;304(10):F1266-73. PubMed PMID: 23408168.
  8. Saad S, Zhang J, Yong R, Yaghobian D, Wong MG, Kelly DJ, et al. Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia. 2013 May;56(5):1174-82. PubMed PMID: 23370527.
  9. Huang C, Shen S, Ma Q, Chen J, Gill A, Pollock CA, et al. Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-beta1/Smad pathway in diabetic mice. Diabetes. 2013 Aug;62(8):2923-34. PubMed PMID: 23656889. Pubmed Central PMCID: 3717839.
  10. Cheng D, Shen S, Chen XM, Pollock C, Braet F. Application of transmission electron tomography for modeling the renal corpuscle. Pathology, research and practice. 2013 Nov;209(11):731-4. PubMed PMID: 24064283.
  11. Wong MG, Panchapakesan U, Qi W, Silva DG, Chen XM, Pollock CA. Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1. American journal of physiology Renal physiology. 2011 Jul;301(1):F84-93. PubMed PMID: 21478477.
  12. Qi W, Holian J, Tan CY, Kelly DJ, Chen XM, Pollock CA. The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-gamma in the regulation of macrophage inflammatory protein-3alpha at early onset of diabetes. The international journal of biochemistry & cell biology. 2011 Mar;43(3):383-92. PubMed PMID: 21109018.
  13. Sumual S, Saad S, Tang O, Yong R, McGinn S, Chen XM, et al. Differential regulation of Snail by hypoxia and hyperglycemia in human proximal tubule cells. The international journal of biochemistry & cell biology. 2010 Oct;42(10):1689-97. PubMed PMID: 20620220.
  14. Vesey DA, Qi W, Chen X, Pollock CA, Johnson DW. Isolation and primary culture of human proximal tubule cells. Methods in molecular biology. 2009;466:19-24. PubMed PMID: 19148604.
  15. Saad S, Agapiou DJ, Chen XM, Stevens V, Pollock CA. The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 Apr;24(4):1130-41. PubMed PMID: 18997160.
  16. Qi W, Chen X, Holian J, Tan CY, Kelly DJ, Pollock CA. Transcription factors Kruppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein. The American journal of pathology. 2009 Nov;175(5):1858-67. PubMed PMID: 19808645. Pubmed Central PMCID: 2774051.
  17. Mather A, Chen XM, McGinn S, Field MJ, Sumual S, Mangiafico S, et al. High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. The international journal of biochemistry & cell biology. 2009 Mar;41(3):561-9. PubMed PMID: 18692592.
  18. Chen XM, Qi W, Pollock CA. CTGF and chronic kidney fibrosis. Frontiers in bioscience. 2009;1:132-41. PubMed PMID: 19482689.
  19. Qi W, Chen X, Poronnik P, Pollock CA. Transforming growth factor-beta/connective tissue growth factor axis in the kidney. The international journal of biochemistry & cell biology. 2008;40(1):9-13. PubMed PMID: 17300978.
  20. Stevens VA, Saad S, Chen XM, Pollock CA. The interdependence of EGF-R and SGK-1 in fibronectin expression in primary kidney cortical fibroblast cells. The international journal of biochemistry & cell biology. 2007;39(5):1047-54. PubMed PMID: 17382577.
  21. Qi W, Johnson DW, Vesey DA, Pollock CA, Chen X. Isolation, propagation and characterization of primary tubule cell culture from human kidney. Nephrology. 2007 Apr;12(2):155-9. PubMed PMID: 17371339.
  22. Qi W, Chen X, Zhang Y, Holian J, Mreich E, Gilbert RE, et al. High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2007 Nov;22(11):3147-53. PubMed PMID: 17664181.
  23. Qi W, Chen X, Twigg S, Zhang Y, Gilbert RE, Kelly DJ, et al. The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology. 2007 Jun;12(3):267-74. PubMed PMID: 17498122.
  24. Qi W, Chen X, Gilbert RE, Zhang Y, Waltham M, Schache M, et al. High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1. The American journal of pathology. 2007 Sep;171(3):744-54. PubMed PMID: 17675577. Pubmed Central PMCID: 1959480.
  25. Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J, et al. Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Molecular and cellular biology. 2006 Mar;26(6):2055-64. PubMed PMID: 16507986. Pubmed Central PMCID: 1430292.
  26. Whitney EM, Ghaleb AM, Chen X, Yang VW. Transcriptional profiling of the cell cycle checkpoint gene kruppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis. Gene expression. 2006;13(2):85-96. PubMed PMID: 17017123. Pubmed Central PMCID: 1626270.
  27. Qi W, Chen X, Twigg S, Polhill TS, Gilbert RE, Pollock CA. Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney international. 2006 Mar;69(6):989-95. PubMed PMID: 16528248.
  28. Qi W, Chen X, Poronnik P, Pollock CA. The renal cortical fibroblast in renal tubulointerstitial fibrosis. The international journal of biochemistry & cell biology. 2006 Jan;38(1):1-5. PubMed PMID: 16230044.
  29. Qi W, Chen X, Polhill TS, Sumual S, Twigg S, Gilbert RE, et al. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American journal of physiology Renal physiology. 2006 Mar;290(3):F703-9. PubMed PMID: 16204411.
  30. Qi W, Chen X, Holian J, Mreich E, Twigg S, Gilbert RE, et al. Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American journal of physiology Renal physiology. 2006 Nov;291(5):F1070-7. PubMed PMID: 16720864.
  31. Qi W, Twigg S, Chen X, Polhill TS, Poronnik P, Gilbert RE, et al. Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. American journal of physiology Renal physiology. 2005 Apr;288(4):F800-9. PubMed PMID: 15536170.
  32. Panchapakesan U, Sumual S, Pollock CA, Chen X. PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. American journal of physiology Renal physiology. 2005 Nov;289(5):F1153-8. PubMed PMID: 15886275.
  33. Panchapakesan U, Chen XM, Pollock CA. Drug insight: thiazolidinediones and diabetic nephropathy--relevance to renoprotection. Nature clinical practice Nephrology. 2005 Nov;1(1):33-43. PubMed PMID: 16932362.
  34. Panchapakesan U, Pollock CA, Chen XM. The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells. American journal of physiology Renal physiology. 2004 Sep;287(3):F528-34. PubMed PMID: 15113752.
  35. Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, et al. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. American journal of physiology Gastrointestinal and liver physiology. 2004 Jan;286(1):G23-30. PubMed PMID: 12919939.
  36. Yoon HS, Chen X, Yang VW. Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. The Journal of biological chemistry. 2003 Jan 24;278(4):2101-5. PubMed PMID: 12427745. Pubmed Central PMCID: 2229830.
  37. Dang DT, Chen X, Feng J, Torbenson M, Dang LH, Yang VW. Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene. 2003 May 29;22(22):3424-30. PubMed PMID: 12776194. Pubmed Central PMCID: 2275074.
  38. Chen X, Whitney EM, Gao SY, Yang VW. Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. Journal of molecular biology. 2003 Feb 21;326(3):665-77. PubMed PMID: 12581631. Pubmed Central PMCID: 2693487.
  39. Sun R, Chen X, Yang VW. Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation. The Journal of biological chemistry. 2001 Mar 9;276(10):6897-900. PubMed PMID: 11152667. Pubmed Central PMCID: 2268089.
  40. Chen X, Johns DC, Geiman DE, Marban E, Dang DT, Hamlin G, et al. Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. The Journal of biological chemistry. 2001 Aug 10;276(32):30423-8. PubMed PMID: 11390382. Pubmed Central PMCID: 2330258.



Xin-Ming Chen

Senior Research Fellow

: (02) 9926 4780
Fax: (02) 99265715

  • DEPARTMENT

    Department of Renal Medicine
    Kolling Institute
    University of Sydney.

  • COUNTRY USA