Publications

Research Publications, Peer Reviewed 

  1. Salant DJ, Belok S, Madaio MP, Couser WG: A new role for complement in experimental nephropathy in rats. J Clin Invest 66: 1339-1350, 1980
  2. Salant DJ, Madaio MP, Adler S, Stilmant MM, Couser WG: Altered glomerular permeability induced by F(ab')2 and Fab antibodies to renal tubular epithelial antigen. Kidney Int 21: 36-43, 1982
  3. Madaio MP, Salant DJ, Cohen A, Adler S, Couser WG: A comparative study of subepithelial immune deposit formation in active and passive Heymann nephritis. Kidney Int 23: 498-505, 1983
  4. Adler S, Salant DJ, Dittmer JE, Rennke HC, Madaio MP, Couser WG: Mediation of proteinuria in membranous nephropathy due to a planted glomerular antigen. Kidney Int 23: 807-815, 1983
  5. Shoenfeld Y, Isenberg DA, Rauch J, Madaio MP, Stollar BD, Schwartz RS: Idiotypic cross reactions of monoclonal human lupus autoantibodies. J Exp Med 158: 718-730, 1983
  6. Madaio MP, Hodder S, Schwartz RS, Stollar, BD: Responsiveness of autoimmune mice to nucleic acid antigens. J Immunol 132: 872-876, 1984
  7. Isenberg DA, Shoenfeld Y, Madaio MP, Rauch J, Reichlin M, Stollar BD, Schwartz RS: Measurement of anti-DNA idiotypes to monitor the course of systemic lupus erythematosus. Lancet 417-422, 1984
  8. Madaio MP, Salant DJ, Adler S, Darby C, Couser WG: Effect of antibody charge and concentration on deposition of antibody to glomerular basement membrane. Kidney Int 26: 397-403, 1984
  9. Gavalchin J, Nicklas JA, Eastcott JW, Madaio MP, Stollar BD, Schwartz RS, Datta S: Lupus prone (SWRXNZB) F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent. J Immunol 134: 885-894, 1985
  10. Naparstek Y, Duggan D, Schattner A, Madaio MP, Goni F, Frangione B, Stollar BD, Kabat EA, Schwartz RS: Immunochemical similarities between monoclonal anti-DNA lupus autoantibodies. J Exp Med 161:1525-1538, 1985
  11. Madaio MP, Adler S, Groggel GC, Couser WG, Salant DJ: Charge selective properties of the glomerular capillary wall influence antibody binding in rat membranous nephropathy. Clin Immunol Immunopathol 39:131-138, 1986
  12. Madaio MP, Schattner A, Schattner M, Schwartz RS: Lupus serum and normal serum contain anti-DNA antibodies with the same idiotypic marker. J Immunol 137:2535-2540, 1986
  13. Madaio MP, Cataldo J, Pankewycz OG, Migliorini P: Monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J Immunol 138:2883-2889, 1987
  14. Canzanello VJ, Madaio MP, Madias NE: Enalapril in the management of hypertension associated with renal artery stenosis. J Clin Pharmacol 27:32-40, 1987
  15. Pankewycz OG, Migliorini P, Madaio MP: Polyreactive autoantibodies are nephritogenic in murine lupus nephritis. J Immunol 139:3287-3294, 1987
  16. Madaio MP, Speigel JE, Levey AS: Life-threatening thrombocytopenia complicating ATG therapy for acute kidney transplant rejection: Evidence for in situ immune complex formation on the platelet surface. Transplantation 45:647-670, 1988
  17. Carlson JA, Hodder SR, Ucci AA, Madaio MP: Glomerular localization of circulating single-stranded DNA in mice: Dependence on the molecular weight of DNA. J Autoimmunity 1:231-241, 1988
  18. Naparstek Y, Baur K, Reis MD, Breitman L, Mak TW, Schwartz RS, Madaio MP: Autoreactive T cells with atypical MHC restriction from MRL-lpr/lpr mice: forbidden clones revisited. J Mol Cell Immunol 4:35-43, 1988
  19. Sabbaga J, Line SRP, Potocnjak P, Madaio MP: A murine nephritogenic monoclonal anti-DNA autoantibody binds directly to mouse laminin, the major noncollagenous protein component of the glomerular basement membrane. Eur J Immunol 19:137-143, 1989
  20. Zouali M, Madaio MP, Canoso R, Stollar BD: Restriction fragment length polymorphism analysis of the V locus in human lupus. Eur J Immunol 19:1757-60, 1989
  21. Sabbaga J, Pankewycz OG, Lufft V, Schwartz RS, Madaio MP: Cross-reactivity distinguishes serum and nephritogenic anti-DNA antibodies in human lupus from their natural counterparts in normal serum. J Autoimmunity 3:215-235, 1990
  22. Puccetti A, Migliorini P, Sabbaga J, Madaio MP: Human and murine anti-DNA antibodies induce the production of anti-idiotypic antibodies with autoantigen binding properties through immune network interactions. J Immunol 145:4229-4237, 1990
  23. Naparstek Y, Ben-Yehuda A, Madaio MP, Bar-Tana R, Schuger L, Pizov G, Neeman Z, Cohen IR: Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin.  Arthritis and Rheum 33: 1554-1559, 1990
  24. Vlahakos DV, Canzanello VJ, Madaio MP, Madias NE: Enalapril-associated anemia in renal transplant recipients treated for hypertension. Amer J Kid Dis 17: 199-205, 1991
  25. Deusch K, Fernandez-Botran, R. Konstadoulakis M, Baur K, Schwartz RS, Madaio MP: Autoreactive T cells from MRL-lpr/lpr mice secrete multiple lymphokines and induce the production of IgG anti-DNA antibodies.  J Autoimmunity 4: 563-576, 1991
  26. Foster MH, Barrett KJ, Madaio MP: MRL-lpr/lpr mice express VH J558 genes to produce anti-DNA antibodies with nephritogenic properties.   J Immunol 147: 1504-1511, 1991
  27. Vlahakos DV, Foster MH, Ucci AA, Barrett KJ, Datta SD, Madaio MP: Murine monoclonal anti-DNA antibodies penetrate cells bind to nuclei and induce glomerular proliferation and proteinuria in vivo.  J Am Soc Neph 2:1345-1354, 1992
  28. Vlahakos DV, Foster MH, Adams S, Ucci AA, Barrett KJ, Datta SD, Madaio MP: Monoclonal anti-DNA antibodies derived from lupus-prone mice form immune deposits at distinct glomerular locations and induce different structural and functional abnormalities in vivo. Kidney Int 41:1690-1700, 1992
  29. Foster MH, Madaio MP, Barrett KJ: Variable region sequence analysis of anti-DNA antibodies: Evidence for a family of closely related germline VH genes encoding lupus autoantibodies.  DNA Cell Biol11:175-182, 1992
  30. Katz MS, Foster MH, Madaio MP: Independently derived murine glomerular immune deposit forming anti-DNA antibodies are encoded by near identical VH gene sequences. J Clin Invest 91:402-408, 1993
  31. Foster MH, Sabbaga J, Line SRP, Thompson K, Barrett KJ, Madaio MP: Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. J Immunol 151: 849-857, 1993
  32. Yanase K, Smith RM, Cizman B, Foster MH, Peachey LD, Jarett L, Madaio MP: A subgroup of murine monoclonal anti-DNA antibodies traverse the cytoplasm and enter the nucleus in a time and temperature dependent manner.  Lab Invest71:52-60, 1994
  33. Duan JM, Madaio MP: Activation of autoreactive T cells from MRL-lpr/lpr mice requires self antigens processed through chloroquine and brefeldin A sensitive pathways.  Lupus 3:525-26, 1994
  34. Shlomchik MJ, Madaio MP, Ni D, Trounstein M, Huszar D: The role of B cells in lpr/lpr-induced autoimmunity. J Exp Med 180: 1295-1306, 1994
  35. Weiss RA, Madaio MP, Tomaszewski JE, Kelly CK:T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.   J Exp Med 180: 2239-2250, 1994
  36. deSousa S, Madaio MP, Neto LJ, Bretani RR: A Monoclonal autoantibody against a complementary peptide recognizes interstitial collagenase.  Immunomethods 5: 172-176, 1994
  37. Foster MH, Kieber-Emmons TK, Ohliger M, Madaio MP: Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies.  Immunol Res 13:172-185, 1994
  38. Kieber-Emmons TK, Foster MH, Williams WV Madaio, MP: Structural properties of a subset of nephritogenic anti-DNA antibodies. Immunol Res 13:186-206, 1994
  39. Cottiero RA, Madaio MP, Levey AS: Glomerular filtration rate and urinary albumin excretion rate in systemic lupus erythematosus.  Nephron69:140-145, 1995
  40. Puccetti A, Madaio MP, Bellese G, Migliorini P: Anti-DNA antibodies bind to DNase 1.  J Exp Med 181: 1797-1804, 1995
  41. Marchini B, Puccetti A, Dolcher MP, Madaio MP. Migliorini P: Induction Of anti-DNA antibodies in non autoimmune mice by immunization with a DNA-DNAase-I complex.  Clin Exp Rheum 13: 7-10, 1995
  42. Faulds G, Conroy S,Madaio MP, Isenberg D, Latchman D: Increased levels of antibodies to HSPs with increasing age in MRL-lpr/lpr mice.  British J Rheum 34: 610-615, 1995
  43. Duan JM, Madaio MP: Abnormal signal transduction through CD4 in autoreactive T cells derived from MRL-lpr/lpr mice. Autoimmunity 3: 525-526, 1994
  44. D'Andrea DM, Coupaye-Gerard B, Kleyman TR, Foster MH, Madaio MP: Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens to initiate different nephritic phenotypes in mice. Kidney Int 49: 1214-1221, 1996
  45. Peng SL, Madaio MP, Hughes DPM, Crispe N, Owen MJ, Hayday AC, Craft J: αβT cell dependent contributions to autoimmunity in lupus-prone MRL/Mp-lpr/lpr mice. J Immunol 156: 4041-4049, 1996
  46. Kalluri R, Petrides S, Wilson CB, Tomaszweski JE, Palevsky HI, Grippi MA, Madaio MP, Neilson EG: Anti1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as Goodpasture's syndrome. Ann Int Med 124: 651-653, 1996 
  47. Ma J, Xu J, Madaio MP, Peng Q, Zhang J, Grewal IS, Flavell R, Craft J: Autoimmune lpr/lpr mice deficient in CD40 ligand. Spontaneous Ig class switching with dichotomy of autoantibody response. J Immunol 157: 417-426, 1996
  48. Peng SL, Madaio MP, Hayday AC, Craft J: Propagation and regulation of systemic autoimmunity by γδT cells.  J Immunol 157:5689-5698, 1996
  49. Peng SL, Madaio MP, Craft J: Systemic autoimmunity in LG/J mice. Immunology Letters 53:153-155, 1996
  50. Madaio MP, Fabbi M, Tiso M, Daga A, Millo R, Puccetti A: Nuclear localizing anti-DNA antibodies inhibit internucleosomal DNA degradation in vivo. Eur J Immunol 26: 3035-41, 1996 
  51. Vargas MT, Gustilo K, D'Andrea DM, Foster MH, Kalluri R, Madaio MP: Structural features of nephritogenic lupus autoantibodies. Methods 11: 62-67, 1997
  52. Peng SL, Madaio MP, Hayday AC, Craft J: αβ T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J Immunol 158:2464-2478, 1997
  53. Kalluri R, Meyers K, Mogyorosi A, Madaio MP, Neilson EG: Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. J Am Soc Nephrol 8: 1795-800, 1997
  54. Yanase K, Smith RM, Puccetti A, Jarett L Madaio MP: Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1.  J Clin Invest 100: 25-31, 1997
  55. Meyers KEC, Kinnery PA, Kalluri R, Neilson EG, Madaio MP: Human Goodpasture anti (IV) collagen autoantibodies share structural determinants. Kidney Int 53: 402-407, 1998
  56. Peng SL, Cappadona J, McNiff JM, Madaio MP, Owen MJ, Hayday AC, Craft J: Pathogenesis of autoimmunity in  cell deficient lupus-prone mice. Clin Exp Immunol 111: 107-116, 1998
  57. Zaiou M, Azrolan N, Hayek T, Wang H, Wu L, Haghpass M, Cizman B, Madaio MP, Milbrant J, Marsh JB, Breslow JL, Fisher EA: The full induction of human apoprotein A-1 gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base pair promotor region and the trans-acting factor early growth response factor 1. J Clin Invest 101: 1699-1707, 1998
  58. Sutmuller M, Baelde JJ, Madaio MP, Bruijn JA, De Heer E: Idiotype usage by polyclonally activated B cells in experimental autoimmunity and infection. Clin Exp Immunol 115:  275-80, 1999
  59. Chen F, Maldonado MA, Madaio MP, Eisenberg RA: The role of host (endogenous) T cells in chronic graft-versus-host autoimmune disease. J Immunol; 161: 5880-5, 1999
  60. Maldonado MA, Kakkanaiah V, MacDonald GC, Chen F Reap, EA Balish, E Farkas WR, Jennette JC, Madaio MP, Kotzin BL, Cohen PL, Eisenberg RA: The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J Immunol 162: 6322-30, 1999
  61. Lin J, Yanase K, Rutgers A, Madaio MP, Meyers KEC: Selection of phage from display libraries: monoclonal antibody against VCS M13 helper phage coat protein III (gpIIIp). Hybridoma 18: 257-261, 1999
  62. Chan OT, Hannum LG, Haberman AM, Madaio MP, Shlomchik MJ: A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells murine lupus.  J Exp Med 189: 1639-1647, 1999
  63. Chan OT, Madaio MP, Shlomchik MJ: B cells are required for lupus nephritis in the polygenic fas-intact MRL model of systemic autoimmunity. J Immunol 163: 3592-96, 1999
  64. Feuerstein N, Chen F, Madaio MP, Maldonado MA, Eisenberg RA: Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor- induced tyrosine phosphoprotiens. J Immunol 163: 5287-97, 1999
  65. Mandik-Nayak L, Nayak S, Sokol C, Eaton-Bassiri A, Madaio MP, Caton AJ, Erikson J: The origin of anti-nuclear antibodies in bcl-2 transgenic mice. Int Immunol 12: 353-364, 2000
  66. Eaton-Bassiri A, Mandik-Nayak L, Seo SJ, Madaio MP, Cancro MP, Erikson J: Alterations in splenic architecture and the localization of anti-double stranded DNA B cells in aged mice. Int  Immunol 12: 915-926, 2000
  67. Rutgers A, Meyers KEC, Canziani G, Kalluri R, Lin J, Madaio MP: High affinity of anti-GBM antibodies from Goodpasture and transplanted Alport patients to alpha3(IV)NC1 collagen. Kidney Int 58:115-22, 2000
  68. Sogabe H, Nangaku M, Ishibashi Y, Wada T, Fujita T Sun X, Miwa T, Madaio MP, Song WC: Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis. J Immunol 167: 2791–2797, 2001
  69. Fields ML, Sokol CL, Eaton-Bassiri A, Seo S, Madaio MP, Erikson J: Fas/fas ligand deficiency results in altered localization of anti- double-stranded DNA B cells and dendritic cells. J Immunol 167: 2370-8, 2001
  70. Meyers KEC, Allen JA, Gehret J, Jacobovits A, Gallo M, Neilson, EG, Hopfer H, Kalluri R, Madaio MP: Human glomerular basement membrane autoantibody disease in Xenomouse II. Kidney Int 61: 1666-73, 2002
  71. Sekiguchi DR, Jainandunsing SM, Fields ML, Maldonado MA, Madaio MP, Erikson J, Weigert M, Eisenberg RA: Chronic graft-versus-host in Ig knockin transgenic mice abrogates B cell tolerance in anti-double-stranded DNA B cells. J Immunol 168: 4142-53, 2002
  72. Bloom RD, O’ConnorT, CizmanB, KalluriR, NajiA, Madaio MP: Intrathymic kidney cells delay the onset of lupus nephritis in MRL-lpr/lpr mice. Int Immunol: 14:867-871, 2002
  73. Yin Z,Bahtiyar G, Zhang N,  Liu, L, Madaio MP, Craft J: IL-10 regulates murine lupus J Immunol 168: 4142-53, 2002
  74. Miwa T, Maldonado MA, Zhou L, Sun X, Cai DW, Werth V, Madaio MP, Eisenberg RA, Song W-C: Deletion of decay-accelerating factor (DAF CD55) exacerbates autoimmune disease development in MRL/lpr mice. Am J Pathol. Am J Pathol  161: 1077-86, 2003
  75. Schiffer L, Sinha J, Wang X, Huang W, Von Gonsdorff G, Schiffer M, Madaio MP, Davidson A: short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F (1) mice by a mechanism downstream of renal immune complex deposition. J Immunol 171: 489-97, 2003
  76. Hancock WW, Tsai TL, Madaio MP, Gasser DL:Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171:2778-8, 2003
  77. Auborn KJ, Xiao MQ, Yan XJ, Teichberg S, Chen D, Madaio MP, Chiorazzi N: Lifespan is prolonged in autoimmune-prone (NZB/NZW)F1 mice fed a diet supplemented with indole-3-carbinol. J  Nutr 133: 3610–13, 2003
  78. Kong PL, Zhu T, Madaio MP, Craft J: Role of the H-2 haplotype in Fas-intact lupus-prone MRL mice: association with autoantibodies but not renal disease.
  79. Arthritis Rheum 48:2992-5, 2003 Akis N, Madaio MP. Isolation, culture and characterization of endothelial, visceral epithelial, and mesangial cells from mouse glomeruli. Kidney Int  65: 2223-38, 2004 
  80. Peng M, Jarett L, Meade, R, Madaio MP, Hancock WW, George AL, Neilson EG, Gasser DL: Mutant prenlytransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice. Kidney Int 66: 1-10, 200
  81. Ramanujam M, Wang X, Huang W, Schiffer L, Grimaldi C, Akkerman A, Diamond B, Madaio MP, Davidson A. Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus.J Immunol 173: 3524-34, 2004
  82. Akkerman A, Huang W, Wang X, Ramanujam M, Schiffer L, Madaio M, Factor SM, Davidson A. CTLA4Ig Prevents Initiation but not Evolution of Anti-phospholipid Syndrome in NZW/BXSB Mice. Autoimmunity 37 445-51, 2004
  83. Yanase K, Madaio MP: Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53. J Autoimmun 24: 145-51, 2005
  84. Feliers D, Chen X, Akis N, Choudhury GG, Madaio M, Kasinath BS. VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells. Kidney Int 68:1648-59, 2005
  85. Barisoni L, Madaio MP, Eraso M, Gasser DL, Nelson PJ. The kd/kd Mouse Is a Model of Collapsing Glomerulopathy. J Am Soc Nephrol 16:: 2847-51, 2005   
  86. Madaio MP, Ahima R, Meade R, Rader DJ, Mendoza A, Peng M, Tomaszewski JE, Hancock WW, Gasser DL. Glomerular and tubular epithelial defects in kd/kd mice lead to progressive renal failure. Am J. Kid Dis 6: 604-10, 2005
  87. ChristensenM, Su AW, Snyder RW, Greco A, Lipschutz JH, Madaio, MP.  Simvastatin protection against acute immune-mediated glomerulonephritis in mice. Kidney Int   69: 457-66, 2006
  88. Hallman T, Peng M, Meade R, Hancock WW, Madaio MP, Gasser DL. The mitochondrial and kidney disease phenotypes of kd/kd mice under germfree conditions. J Autoimmunity 26:1-6, 2006
  89. Kaneko Y, Nimmerjahn F, Madaio MP, Ravetch JV. J Exp Med. Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. J Exp Med 203: 789-97, 2006
  90. Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol 17:1886-95, 2006
  91. Bergtold A, Gavhane A, D'Agati V, Madaio M, Clynes R.FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis. J Immunol 177:7287-95, 2006
  92. Ma Z, Chen F, Madaio MP, Cohen PL, Eisenberg RA.Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus. J Immunol 177:7444-50, 2006
  93. Miwa T, Zhou L, Tudoran R, Lambris JD, Madaio MP, Nangaku M, Molina H, Song WC.DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity. Mol Immunol  44: 139-46, 2007
  94. Frisoni L, McPhie L, Kang SA, Monestier M, Madaio M, Satoh M, Caricchio R. Lack of chromatin and nuclear fragmentation in vivo impairs the production of lupus anti-nuclear antibodies. J Immunol 179:7959-66, 2007
  95. Schiffer L, Bethunaickan R, Ramanujam M, Huang W, Schiffer M, Tao H, Madaio MM, Bottinger EP, Davidson A. Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis. J Immunol 180:1938-47, 2008
  96. Kahn P, Ramanujam M, Bethunaickan R, Huang W, Tao H, Madaio MP, Factor SM, Davidson A. .Prevention of murine anti-phospholipid syndrome by BAFF blockade. Arthritis Rheum 58:2824-34, 2008 
  97. Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, Cohen PL, Eisenberg RA. B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol 181(5):2961-72, 2008
  98. Petri M, Kasitanon N, Lee SS, Link K, Magder L, Bae SC, Hanly JG, Isenberg DA, Nived O, Sturfelt G, van Vollenhoven R, Wallace DJ, Alarcón GS, Adu D, Avila-Casado C, Bernatsky SR, Bruce IN, Clarke AE, Contreras G, Fine DM, Gladman DD, Gordon C, Kalunian KC, Madaio MP, Rovin BH, Sanchez-Guerrero J, Steinsson K, Aranow C, Balow JE, Buyon JP, Ginzler EM, Khamashta MA, Urowitz MB, Dooley MA, Merrill JT, Ramsey-Goldman R, Font J, Tumlin J, Stoll T, Zoma A. Systemic Lupus International Collaborating Clinics. Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index. Arthritis Rheum 58:1784-88, 2008
  99. Petri M, Kasitanon N, Singh S, Link K, Magder L, Bae SC, Hanly JG, Nived O, Sturfelt G, van Vollenhoven R, Wallace DJ, Alarcón GS, Adu D, Avila-Casado C, Bernatsky SR, Bruce IN, Clarke AE, Contreras G, Fine DM, Gladman DD, Gordon C, Kalunian KC, Madaio MP, Rovin BH, Sanchez-Guerrero J, Steinsson K, Aranow C, Balow JE, Buyon JP, Ginzler EM, Khamashta MA, Urowitz MB, Dooley MA, Merrill JT, Ramsey-Goldman R, Font J, Tumlin J, Stoll T, Zoma A. Systemic Lupus International Collaborating Clinics. .Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response. Arthritis Rheum 58:1789-95, 2008
  100. Ramanujam M,   Kahn P,  Huang W,   Tao H,1   Madaio MP, Factor SM,    Davidson A. Interferon Treatment of Female (NZWxBXSB)F1 Mice Mimics Some but Not All Features Associated With the Yaa Mutation. Arthritis Rheum 60: 1096-1101, 2009
  101. Yan XJ, Qi M, Telusma G, Yancopoulos S, Madaio M, Satoh M, Reeves WH, Teichberg S, Kohn N, Auborn K, Chiorazzi N. Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades.Clin Immunol 131: 481-494, 2009 
  102. Jog NR, Dinnall JA, Gallucci S, Madaio MP, Caricchio R. Poly (ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. J Immunol 182:7297-306, 2009
  103. Meyers KE, Christensen M, Madaio MP. Modeling of human anti-GBM antibody-alpha3(IV)NC1 interactions predicts antigenic cross-linking through contact of both heavy chains with repeating epitopes on alpha3(IV)NC1.Am J Nephrol  30:474-80, 2009
  104. Ramanujam M, Bethunaickan R, Huang W, Tao1 H, Madaio MP, Davidson A. Selective blockade of BAFF prevents and treats SLE nephritis in NZM2410 mice. Arthritis Rheum 62:1457-68, 2010  
  105. Liu Z, Bethunaickan R, Huang W, Lodhi U, Solano I, Madaio MP, Davidson A. Interferon  accelerates murine SLE in a T cell dependent manner. Arthritis Rheum.  63:219-29, 2011
  106. Sapienza C, Lee J, Powell J, Erinle O, YafaiF, Reichert J, Siraj ES, Madaio M. DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy. Epigenetics. 6:20-8, 2011
  107. Liu Z, Bethunaickan R, Huang W, Ramanujam M, Madaio MP, Davidson A. IFN- Confers Resistance of Systemic Lupus Erythematosus Nephritis to Therapy in NZB/W F1 Mice. J Immunol.187:1506-13, 2011
  108. McGaha TL, Ma Z, Ravishankar B, Gabunia K, McMenamin M, Madaio MP. Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice.Autoimmunity. 279-89, 2012
  109. Bethunaickan R, Sahu R, Liu Z, Tang YT, Huang W, Edegbe O, Tao H, Ramanujam M, Madaio MP, Davidson A. Anti-tumor necrosis factor α treatment of interferon-α-induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation.Arthritis Rheum. 64: 3399-408, 2012 
  110. Miwa T, Zhou L, Maldonado MA, Madaio MP, Eisenberg RA, Song WC. Absence of CD59 Exacerbates Systemic Autoimmunity in MRL/lpr Mice.J Immunol.  189 5434-41, 2012 
  111. Kvirkvelia N, McMenamin M, Chaudhary K, Bartoli M, Madaio MP. Prostaglandin E2 promotes cellular recovery from established nephrotoxic serum nephritis in mice, prosurvival, and regenerative effects on glomerular cells.Am J Physiol Renal Physiol. 304:F463-70, 2013
  112. Chaudhary K, Kleven DT, McGaha TL, Madaio MP. A human monoclonal antibody against the collagen type IV α3NC1 domain is a non-invasive optical biomarker for glomerular diseases.Kidney Int. 84: 403-08, 2013
  113. Hess C, Winkler A, Lorenz AK, Holecska V, Blanchard V, Eiglmeier S, Schoen AL, Bitterling J, Stoehr AD, Petzold D, Schommartz T, Mertes MM, Schoen CT, Tiburzy B, Herrmann A, Köhl J, Manz RA, Madaio MP, Berger M, Wardemann H, Ehlers M.T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest.123:3788-96, 2013
  114. Caza TN,Fernandez DR,Talaber G, Oaks Z, Haas M,Madaio MP,Lai Z, Miklossy G,Singh RR,Chudakov DM,Malorni W,  Middleton F, Bank K,Perl A. HRES-1/Rab4-mediated depletion of Drp1 impairsmitochondrial homeostasis and represents a targetfor treatment in SLE, Ann Rheum Dis 2013 In press
  115. Rangachari P, Madaio M, Rethemeyer RK, Wagner P, Hall L, Roy S, Rissing P. The evolution of knowledge exchanges enabling successful practice change in two intensive care units. Health Care Manage Rev. 2014In press

Editorials, Reviews Chapters:

  1. Couser WG, Salant DJ, Madaio MP, Adler S: Mechanisms of immune Complex Injury, in Proceedings of the Fifth International Pediatric Nephrology Symposium, Philadelphia, Marinus Nilhoff BV, The Hague, Netherlands, 1980
  2. Couser WG, Salant DJ, Madaio MP, Adler S, Groggel GC: Factors influencing glomerular and tubulointerstitial patterns of injury in SLE. Am J Kidney Dis 2: Suppl 1,126-134, 1982
  3. Couser WG, Salant DJ, Adler S, Madaio MP: Studies of experimental membranous nephropathy. Transplant Proc 14: 474-481, 1982
  4. Madaio MP, Harrington JT: The diagnosis of acute glomerulonephritis. N Engl J Med 309:1299-1302,1983
  5. Madaio MP: Pathogenesis of IgA nephropathy, in Nephrology Forum; Idiopathic IgA nephropathy, Rodicio JL (principal discussant). Kidney Int 25:717-729, 1984
  6. Madaio MP: Deciphering the pathogenesis of systemic lupus erythematosus: the use of monoclonal autoantibodies as probes. Plasma Ther Transfus Technol 5:481-495 1984
  7. Madaio MP: Glomerular disorders, in Conn's Current Therapy WB Saunders Co,  Philadelphia: 539-547, 1986
  8. Madaio MP: Postgraduate Nephrology, Book Review: N Engl J Med 314: 1717, 1986
  9. Stollar CA, Shah BV, Madaio MP: Nutrition and the kidney, Book Review: N Engl J Med 318:1476-77, 1988
  10. Madaio MP: Glomerular disorders in Conn's Current Therapy WB Saunders Co, Philadelphia: 546-554, 1987
  11. Madaio MP: Renal biopsy, in Nephrology Forum Kidney Int 38:529-543, 1990
  12. Levey AS, Madaio MP, Perrone RD: Laboratory assessment of renal diseases: clearance, urinalysis and renal biopsy, in The Kidney, Brenner BM, Rector FC Jr ed, WB Saunders Co, Philadelphia, 4th ed: 919-968, 1991
  13. Madaio MP: Post-streptococcal glomerulonephritis, in The Principles and Practice of Nephrology, Jacobsen HR, Stricker GE, Klahr S ed BC Decker, Inc Philadelphia, 262-265, 1991
  14. Foster MH, Madaio MP: Glomerulonephritis, in Current Diagnosis, Eighth Edition, Conn, RB ed, WB Saunders Co, Philadelphia, 1991
  15. Madaio MP: Current Therapy in Nephrology and Hypertension, Book Review. N Engl J Med 326:1167-68-77,1992
  16. Mackworth-Young CG, Madaio MP: Anti-DNA network: Therapeutic considerations. Lupus 1:339-340, 1992
  17. Feldman HI, Madaio MP: Cyclophosphamide in progressive glomerulopathy: Pro and con (letter to the Editor). Ann Int Med 117:696, 1992
  18. Foster MH, Cizman B, Madaio MP: Nephritogenic autoantibodies in systemic lupus erythematosus: Immunochemical properties, mechanisms of immune deposit formation and genetic origins. Invited Review.  Lab Invest 69:494-507, 1994
  19. Bloom RD, Weiss R, Madaio MP: The nephritogenic immune response. Current Science 2:441-448, 1993
  20. Weiss R, Cooperstone B, Bloom RD, Madaio, MP: Glomerulopathies, in Current Nephrology, Volume 18, Gonick H ed, Mosby, Year Book, Inc, St Louis, 18: 251-282, 1994
  21. Madaio MP: Post-infectious glomerulonephritis, in The Principlesand Practice of Nephrology, Jacobsen HR, Stricker GE, Klahr S ed, BC Decker, Inc Philadelphia, Second Edition, 122-127,1995
  22. Kobrin S, Madaio MP: Kidney biopsy, in The Principlesand Practice of Nephrology, Jacobsen HR, Stricker GE, Klaur S ed, BC Decker, Inc Philadelphia, Second Edition, 65-70, 1995
  23. Madaio MP, Shlomchik MJ: Emerging concepts regarding B-cells and autoantibodies in murine lupus nephritis. B-cells have multiple roles - All autoantibodies are not equal. J Am Soc Neph 7:387-396, 1996
  24. Kobrin S, Madaio MP: Post-infectious glomerulonephritis, in Diseases of the Kidney, Schrier RW, Gottschalk CW ed, Little Brown and Co, Boston, 1579-1594,1997
  25. D'Andrea D, Vargas M, Cizman B, Madaio MP: Glomerulopathies, in Current Nephrology, Volume 19, Gonick H ed, Mosby, Year Book, Inc, St Louis, 169-202, 1996
  26. Foster MH, Madaio MP: Molecular structure and expression of nephritogenic autoantibodies, in Immunologic Renal Diseases, Neilson EG, Couser WG ed, Raven Press, New York, 265-290, 1997
  27. D'Andrea D, Meyers KEC, Kalluri R, Madaio MP: Glomerulopathies, in Current Nephrology, Volume 20, Gonick H ed, Mosby, Year Book, Inc, St Louis, 179-208, 1997
  28. Madaio MP, Yanase K, Foster MH, Smith RM, Kieber-Emmons T, Fabbi M, Puccetti A, Jarett L: Nuclear localization of autoantibodies: Novel insights into protein translocation and cellular function in B lymphocytes and autoimmunity.  Ann NY Acad Sci 815: 263-266, 1997
  29. Wang B, Godillot AP, Madaio MP, Weiner DB, Williams WV: Vaccination against pathogenic cells by DNA inoculation, in DNA Vaccination/Genetic VaccinationKoprowski, H, Weiner DB ed Springer, Berlin Heidelberg, 21-36, 1998
  30. Naparstek Y, Madaio MP: Are anti-DNA antibodies actually pathogenic?  Lupus 6: 307-309, 1997
  31. Chan O, Madaio MP, Shlomchik MJ: The roles of B cells in MRL/lpr murine lupus. Ann NYAS 815:75-87, 1997
  32. Madaio MP: B cells and autoantibodies in the pathogenesis of lupus nephritis. Immunol Res 17: 123-132, 1998
  33. Madaio MP, Yanase K: Cellular penetration and nuclear localization of anti-DNA antibodies. J Autoimmun 11: 535-538, 1998
  34. Madaio MP, McCluskey, RT: A 29 year-old woman with necrotizing lymphadenitis, the nephrotic syndrome and acute renal failure.  Case records of the Massachusetts General Hospital. N Engl J Med 339: 1308-13018,1998
  35. Madaio, MP, Yanase, K: Cellular entry and nuclear localization of anti-DNA antibodies, in Autoimmune Reactions Paul, S ed, Humana Press, Totowa, 293-304, 1999
  36. Madaio, MP: The role of autoantibodies in the pathogenesis of lupus nephritis. Semin Nephrol 19: 48-56, 1999
  37. Verma, S, Madaio, MP: Diagnosis and treatment of nephrotic syndrome Exp Opin Invest Drugs 8:787-796, 1999
  38. Madaio, MP: (Editorial): Major peptide autoepitopes for nucleosome-specific T cells of human lupus. Am J Kid Dis 35(5):992-6, 2000
  39. Madaio, MP, Yanase, K: Cellular entry and nuclear localization of Anti-DNA antibodies: insights into the movement of larger proteins in and around cells,  in Current Trends in Immunology Research Trends, Trivandrum, India 3:87-96, 2000
  40. Madaio, MP, Harrington, JT: The diagnosis of glomerular diseases: Acute glomerulonephritis and the nephrotic syndrome. Arch Intern Med: 161: 25-34, 2001
  41. Madaio, MP: Pathogenesis of lupus nephritis, in Rheumatology and the Kidney, Adu, A, Emery, P, Madaio, MP ed Oxford University Press, New York, 61-74, 2001
  42. Foster, MH, Madaio, MP: Molecular structure and expression of nephritogenic autoantibodies in Immunologic Renal Diseases, 2nd Ed, Neilson, EG, Couser, W G ed, Raven Press, New York, 257-27, 2001
  43. Kobrin, S, Madaio, MP: Post-Infectious glomerulonephritis, in Diseases of the Kidney  Schrier, RW, Gottschalk, CW ed Little Brown and Co, Boston, 2002
  44. Madaio, MP, Naparstek, Y: Structural considerations of autoantibodies: Lupus 11: 774-775, 2002
  45. Madaio, MP: Lupus autoantibodies 101: one size does not fit all; however, specificity influences pathogenicity. Clin Exp Immunol 131:396-7. 2003 
  46. Shlomchik MJ, Madaio MP. The role of antibodies and B cells in the pathogenesis of lupus nephritis. Springer Semin Immunopathol;24:363-375, 2003.
  47. Su W, Madaio MP: Recent advances in the pathogenesis of lupus nephritis: Autoantibodies and B cells. Semin Nephrology. 23: 564-569, 2003
  48. Waldman M, Madaio MP: Pathogenic autoantibodies in lupus nephritis. Lupus 14: 19-24, 2005
  49. Joshi M, Madaio MP: Role of Abetimus in systemic lupus erythematosus. Future Rheumatology, 2006
  50. Evolving strategies for the treatment of lupus nephritis and other glomerular diseases. Editor of the American Society of Nephrology monograph. 2006
  51.  Dimitriou SG, Madaio MP: Renal Damage,  in Systemic Lupus Erythematosus, A Companion to Rheumatology. Mosby, Philadelphia.  2007
  52.  Tumlin JA, Madaio MP, Henniger R:  Idiopathic IgA nephropathy: pathogenesis, histopathology, and therapeutic options. Clin J Am Soc Nephrol.  2: 1054-61, 2007
  53. Manoharan, A  Madaio MP: Biomarkers in Lupus Nephritis:  Rheum Dis Clin North Am. 36:131-43, 2010
  54. Ruperto N, Hanrahan LM, Alarcón GS, Belmont HM, Brey RL, Brunetta P, Buyon JP, Costner MI, Cronin ME, Dooley MA, Filocamo G, Fiorentino D, Fortin PR, Franks AG Jr, Gilkeson G, Ginzler E, Gordon C, Grossman J, Hahn B, Isenberg DA, Kalunian KC, Petri M, Sammaritano L, Sánchez-Guerrero J, Sontheimer RD, Strand V, Urowitz M, von Feldt JM, Werth VP, Merrill JT. Lupus Foundation of America, Inc. International Flare Consensus Initiative. Lupus:  20:453-62, 2011
  55. Nahman NS, Madaio MP. Pathogenesis of Lupus Nephritis in Rheumatology and the Kidney, 2nd Ed.    Adu, A, Emery, P, Madaio, MP ed Oxford University Press, New York, 39-56, 2012
  56. Madaio MP. The relevance of antigen binding to the pathogenicity of lupus autoantibodies.Kidney Int. 82:125-7.  2012
  57. Mulloy LM, Madaio MP. Acute Infectious Glomerulonephritis Including Post-streptococcal and Other Bacterial Infection-Related Glomerulonephritis in Schrier’s Diseases of the Kidney. 9thed.Schrier RW, Coffman TM, Falk RJ, Molitoris BA, Neilson EG, Ed. 2:1277-1291, 2013

Books, Monographs:

  • Adu A, Emery P, Madaio MP, ed: Rheumatology and the Kidney, Oxford University Press, New York, 1-546, 2001
  • Silverman G, Clark M, Madaio M, Shlomchik M. The Role of B cells in Lupus. More than just autoantibodies. Lupus Outlook CDROM. Curatio CME Institute,  LLC. 2006.
  • Adu A, Emery P, Madaio MP, ed: Rheumatology and the Kidney, Oxford University Press, New York, 1-466 2012



Madaio Michael P

Sydenstricker Professor and Chairman

: (02) 9926 4780
Fax: (02) 99265715

  • DEPARTMENT

    Medical college of Georgia,
    Georgia Health Sciences University

  • COUNTRY USA