Publications

  1. Zhu G*, Li Y*, Zhu F*, Wang T, Jin W, Mu W, Lin W, Tan W, Sun Q, Jin P and Chen D. 2014. Coordination of engineered factors with TET 1/2 promotes the early stage epigenetic modification during somatic cell reprogramming. Stem Cell Reports 27;2(3):253-61  (* equal contribution)
  2. Leung D, Du T, Wagner U, Xie W, Lee AY, Goyal P, Li, Y, Szulwach KE, Jin P, Lorincz M, and Ren B. 2014. Persistence of DNA methylation in embryonic stem cells depends on the histone methyltransferase Setdb1. PNAS  6;111(18):6690-5
  3. Zhang W*, Cheng Y*, Li Y, Chen Z, Jin P, Chen D 2014. A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response. Hum Mol Genet. 2014 May 15. pii: ddu241. [Epub ahead of print] (* equal contribution)
  4. Guo JU, Szulwach KE, SU Y, Li Y, Yao B, Xu Z, Shin JH, Xie B, GAO Y, Ming GL, Jin P, Song HJ. 2014. Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain. Front. Biol  DOI 10.1007/s11515-014-1295-1
  5. Xu Z, Shi Z, Li Y*. 2014. The Crosstalk between microRNA and iron homeostasis. International journal of Genomic Medicine. (In Press) (*: Corresponding Author)
  6. Xu Z, Shi Z, Li Y*. 2014. Expanded GGGGCC Hexanucleotide Repeats and RNA-binding Proteins in ALS/FTD. Journal of Genetic Syndromes & Gene Therapy. (Invited) (*: Corresponding Author)
  7. Huang H*, Li Y*, Szulwach KE, Zhang G, Jin P, and Chen D. 2014. The AGO3 Slicer controls the dynamic mitochondria-nuage localization of Armitage and contributes to piRNA biogenesis. Journal of Cell Biology 206(2):217-30 (*equal contribution)
  8. Zhu Y*, Li Y*, Lin L, Zhang L, Xu Z, Sun S-Y, Zhang G, Cheng X, Jin P, and Chen D. 2014. p53 and Gadd45a: a new mechanism regulating TET-mediated epigenetic modulation (* Equal Contribution). (Under Review)
  9. Jiang R, Li Y*. 2013. Regulation of miRNA pathway and roles of miRNAs in tumorigenesis and metastasis. Human Genetics and Embryology: Current Research. Special issue 1-10 (* Corresponding author).
  10. Ji P, and Li Y* 2013. Chemical Biology approach for dissection of RNAi/miRNA pathway. Cloning and Transgenesis. 2(1): 1-4. (* Corresponding author)
  11. Li Y, Ji P, Jin P. 2013. Probing the microRNA pathway with small molecules. Bioorg Med Chem. 21(20): 6119-23
  12. Li J, Yuan X, Liu J, and Li Y*.  2013. Medulloblastoma Treatment using Gene Therapy. Journal of Gene Therapy. 1(1): 1-6 (* Corresponding author)
  13. Xu Z, Xu S, Li Y*. 2013.   RNA Dysfunction and RNA binding proteins in the syndrome of ALS/FTD. Journal of Syndromes.1(1): 1-9 (* Corresponding author).
  14. Wang T, Wu H, Li Y, Szulwach KE, Lin L, Li X, Chen I-P, Goldlust I-S, Chamberlain SJ, Ananiev G, Mowrey J, Han JW, Kim M-O, Yoon YS, Rudd MK, Song C-X, He C, Chang Q, Warren ST, Jin P. 2013. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nature Cell Biology 15(6):700-11
  15. Xu Z, Poidevin M, Li X, Li Y, Nelson DL, Li H, Wingo TS, Jin P. 2013. Expanded Hexanucleotide GGGGCC Repeat RNA associated with ALS/FTD is sufficient to cause neurodegeneration. PNAS 110(19):7778-83
  16. Song CX, Szulwach KE, Dai Q, Fu Y, Liu P, Lin L, Street C, Li Y, Xu GL, Jin P, He C. 2013. Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell 153(3):678-91
  17. Li Y, Jin P. 2012. RNA-Mediated Neurodegeneration in Fragile X-associated Tremor/Ataxia Syndrome. Brain Research. 1462:112-7
  18. Li Y, Jin P. 2012. Selective Capture of 5-hydroxymethylcytosine from Genomic DNA. J Vis Exp. Oct 5;(68). doi:pii: 4441. 10.3791/4441  Li Y*, Lin L*, Li Z, Ye X, Aryal B, Paroo Z, Liu Q, He C, and Jin P. 2012 Iron homeostasis pathway modulates microRNA pathway mainly through PCBP2 in mammals. Cell Metabolism 15(6):895-904 (*: equal contribution)
  19.  Szulwach K*, Li X*, Li Y, Song CX, Wu H, Irier H, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, He C, Jin P.   2011. Genome-wide analyses reveal 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging. (*:equal contribution).  Nature Neuroscience Oct 30. doi: 10.1038/nn.2959.
  20. Szulwach K, Li X, Li Y, Song C, Han JW, Kim SS, Namburi S, Hermetz K, J. Kim JI, Rudd MK, Yoon Y-S, Ren B, He C, Jin P.  2011. Integrating 5-hydroxymethylcytosine into the Epigenomic Landscape of Human embryonic Stem Cells. PLos Genetics 2011 Jun; 7(6): e1002154.
  21. Song CX, Szulwach K, Fu Y, Dai Q, Yi C, Li X, Li Y, Chen CH, Zhang W, Jian X, Wang J, Zhang L, Looney TJ, Zhang B, Godley LA, Hicks LM, Lahn BT, Jin P, He C. 2011. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nature Biotechnology 29 (1): 68-72 
  22. Li Y, He C, Jin P. 2010 Emergence of chemical biology approaches to RNAi/microRNA pathway. Chem Biol. 25; 17 (6): 584-9.
  23. Szulwach K*, Li X*, Smrt R, Li Y, Lin L, Santistevan N, Luo Y, Li W, Zhao X, Jin P.  2010. MeCP2-mediated cross-talk between microRNA and epigenetic regulation in adult neural stem cells. (*equal contribution). Journal of Cell Biology. 189(1):127-41
  24. Shan G*, Li Y*, Zhang J, Li W, Szulwach K, Duan R, Faghihi M, Khalil A, Lu L, Paroo Z, Chan A, Shi Z, Liu Q, Wahlestedt C, He C, Jin P. 2008.  A small molecule enhances RNA interference and promotes microRNA processing (*Equal contribution). Nature Biotechnology. 26(8):933-40
  25. Li Y, Lin L, Jin P. 2008. The microRNA pathway and fragile X mental retardation protein. BBA-GENE REGUL MECH. 1779(11): 702-5 
  26. Li Y, Dankher OP, Carreira L, Smith AP, Meagher RB. 2006 The shoot-specific expression of gamma-glutamylcysteine synthetase directs the long-distance transport of hiol-peptides to roots conferring tolerance to mercury and arsenic. Plant Physiology. 141(1): 288-98.
  27. Li Y, Heaton ACP, Carreira L, and R.B. Meagher. 2006. Enhanced tolerance to and accumulation of mercury, but not arsenic, in plants overexpressing two enzymes required for thiol peptide synthesis.  Physiologia Plantarum 128: 48-57
  28. Li Y, Dhankher OP, Carreira L, Balish RS, Meagher RB. Arsenic and mercury tolerance and cadmium sensitivity in Arabidopsis plants expressing bacterial gamma-glutamylcysteine synthetase. Environmental Toxicology and Chemistry. 24(6):1376-86  
  29. Li Y, Dhankher OP, Carreira L, Lee D, Chen A, Schroeder JI, Balish RS, Meagher RB. 2004 Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant and Cell Physiology. 45(12):1787-97 
  30. Zhao X, Li Y, Liu J, Li B, Liu Q, Tong Y, Li J, Li Z. 2004. Isolation and Expression analysis of a high-affinity nitrate transporter TaNRT23 from roots of wheat. Journal of Integrative Plant Biology 46 (3): 347-54 
  31. Dhankher OP, Li Y, Rosen BP, Shi J, Salt D, Senecoff JF, Sashti NA, Meagher 2002 RB.Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression. Nature Biotechnology 20(11): 1140-5.
  32. Alokam S, Li Y, Li W, Chinnappa CC, Reid DM 2002.  Photoregulation of phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS) in the accumulation of anthocyanin in alpine and prairie ecotypes of Stellaria longipes under varied R/FR. Physiologia Plantarum 116: 531-8
  33. Li Y, Kandasamy MK, Meagher RB. 2001 Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway. Plant Physiology. 127(3): 711-9.
  34. Liu J, Li Y, Tong Y, Gao J, Li B, Li J, Li Z 2001 Chromosomal location of genes conferring the tolerance to Pi starvation stress and acid phosphatase (Apase) secretion in the genome pf rye (Secale L.). Plant and Soil 237: 267-74   
  35. Li Y, Liu J, Li B, Li J, Li Z 1999 Chromosomal location of the genes conferring the tolerance to phosphorus deficiency stress in Lophospyrum elongatum genome. ACTA GENETICA SINICA. 26 (6): 703-10
  36. Li Y, Liu J, Li B, Li J, Li Z 1999. Genetic analysis of the genes conferring the tolerance to phosophorus deficiency stress in genome of Triticum aestivum. ACTA GENETICA SINICA 26(5): 529-38
  37. Li Y, Liu J, Li B, Li J, Li Z 1999. Recent advances in molecular biology of genes coding for nitrate, phosphate, and potassium transporters in higher plant. Progress In Biotechnology. 19 (2): 41-47
  38. Li Y, Liu J, Li B, Li J, Li Z 1999 Advances in physiology and biochemistry of tolerance of higher plants to phosphorus deficiency stress. Life Science Research 2(4): 244-252
  39. Liu J, Li B, Li Y, Yao S, Li J, Li Z 1999. Genetic studies of gene effects of wheat genomes on the characteristics of efficiently utilizing potential soil phosphotus. ACTA BOT. Boreal-Occident Sin 19(1): 1-6
  40. Liu J, Li Y, Li B, Yao S, Li J, Li Z 1999. Identification of efficiency utilizing potential soil phosphorus characteristics of common wheat cultivars grown at different periods. ACTA AGRONOMIC SINICA 25(5): 561-65
  41. LI Y, LI ZY, LI Z 1998. Advances in eukarotic mRNA differential display. Biotechnology 14 (5): 23-31
  42. Li Y, Li B, Liu J, Li J, Li Z 1998. Chromosomal location of genes encoding isozymes of acid phosphatase and alkaline phosphatase in Agropyron elongatum (2n=2x=14, EE). ACTA GENETICA SINICA 25 (5): 449-53
  43. Li Y, Liu J, Li B, Li J, Li Z 1998. Influence of phosphorus deficiency stress on acid phosphatase isozymes in wheat. Scientia Agricultra Sinica 31 (4): 26-31
  44. Li Y, Li B, Li J, Li Z 1998. Advances in genetic study on characteristics of plant efficiently utilizing soil phosphorus. Hereditas (Beijing). 20 (3): 38-41
  45. Li Y, Liu J, Li B, Li J, Li Z 1998. Chromosomal location of genes conferring tolerance to iron deficiency in genome of Agropyron juncevum. Agricultural Biotechnology 6: 28
  46. Li Y, Li B, Li J, Li Z 1997. Changes of RNase and acid phosphatase in common wheat under phosphorus deficiency stress. ACTA BOT. Boreal-Occident Sin 417-25
  47. Sun B, Li Y, 1993. The relationship between nitrate reductase activity and the efficient utilization of common wheat to nitrogen. ACTA AG. UNI. PERKINSIS. 19 (3): 29-33

Course Training

  • Short-term course in human embryonic stem cell culture techniques, June, 2008.
  • Homewood Campus of Johns Hopkins University, Baltimore, Maryland, organized by NI

Book Chapter

  • Li Y and Jin P. 2013. Chapter 8. MicroRNA SNPs in Cancer in Non-Coding RNAs and Cancers (eds by Muller_Fabbri, Springer) Pp: 149-164.
  • Willemsen R, Li Y, Berman RF, Brouwer JR, Oostra BA, Jin P, 2010.  ANIMAL MODELS FOR FXTAS. The Fragile X- Associated Tremor Ataxia Syndrome (FXTAS). Springer New York.  Flora Tassone and Elizabeth M. Berry-Kravis (Eds). Pp123-136
  • Dhankher P, Heaton A, Li Y, Meagher RB 2005. Strategy for the engineered phytoremediation of mercury and arsenic pollution. In: Subsurface Contamination Remediation: Accomplishments of the Environmental Management Science Program (ACS Symposium Series) (Eds. Edgar Berkey and Tiffany Zachry) Oxford University Press.  Pp: 96-117
  • Li Y, Zhang FS 1993. Physiological, biochemical, and molecular characteristics of absorption and utilization of plant to nitrate. I. Absorption and assimilation of plants to nitrate. In: Environment stress and Plant Nutrition (eds. Zhang FS). Beijing Agricultural University Press. 1993 Pp: 209-229
  • Li Y, Zhang FS 1993. Physiological, biochemical, and molecular characteristics of absorption and utilization of plant to nitrate. II. Physiological and biochemical characteristics of nitrate reductase (NR) in plant. In: Environment stress and Plant Nutrition (eds. Zhang FS). Beijing Agricultural University Press. 1993 Pp: 230-255
  • Li Y, Zhang FS 1993. Physiological, biochemical, and molecular characteristics of absorption and utilization of plant to nitrate. III. Molecular characteristics of NR in plant and application of NR on plant breeding. In: Environment stress and Plant Nutrition (eds. Zhang FS). Beijing Agricultural University Press. 1993 Pp: 256-294
  • Sun B, Li Y, 1997. Relationship between nitrate reductase activity and grain protein content accumulation in common wheat. In: Seed Industry and Agricultural Development. Chinese Association of Agricultural Science Society and Department of Agriculture, Ministry of Agriculture, PR. CHINA, Pp: 395-7
  • Li Y, Li B, Li J, Yao S, Li Z, 2000. Chromosomal control of tolerance to phosphorus deficiency in genomes of Agropyron juncevum and Agropyron intermedium. In: Symposium of China National Natural Science Foundation on Exploitation of Biological Potential to Efficiently Utilize Soil Nutrients to Maintain Soil Environment. Pp. 18-24
  • Li Y, Li B, Li J, Yao S, Li Z, 2000. Chromosomal control of tolerance to iron deficiency in genomes of Agropyron juncevum. In: Symposium of China National Natural Science Foundation on Exploitation of Biological Potential to Efficiently Utilize Soil Nutrients to Maintain Soil Environment. Pp. 25-27

 Selected Poster Presentation:

  • Li Y, Jin P. 2008. Generation of A BAC transgenic mouse model for FXTAS. Poster presentation. Abstract # 1384. 58th American Society of Human Genetics Annual Meeting. 2008, Philadelphia, Pennsylvania
  • Li Y, Dankher OP, Meagher RB. 2001. Overexpression of enzymes involved in biosynthesis of phytochelatins in Arabidopsis thaliana enhance arsenic and mercury resistance. 2001, Madison, Wisconsin.
  • Li Y, Li B, Li J, Li Z 1998. Chromosomal control of the tolerance to phosphorus deficiency in genome of Agropyron elongatum. Poster presentation. 18th International Congress of Genetics, 1998. Beijing, CHINA. 8P 187
  • Li Y, Li B, Li J, Li Z 1998. Chromosomal control of the tolerance to phosphorus deficiency in genome of common wheat. Poster presentation. 18th International Congress of Genetics, 1998. Beijing, CHINA.  8P 121
  • Dhankher OP, Li Y, Meagher RB. 2001. Phytoremediation of arsenic contaminated soils. ASPB Annual Meeting, 2001, Rhode Island. Poster presentation. Poster # 429
  • Dhankher OP, Li Y, Rosen BP, Salt D, Meagher RB. 2002. Resistance and Accumulation of Arsenic by plants expressing bacterial arsenic reductase and gamma-glutamylcysteine synthetase. 10th IAPTC & B Congress Plant Biotechnology 2002 and Beyond  A celebration and a Showcase. Disney’s Coronado Spring Resort at Walt Disney World Resort. 2002
  • Meagher RB, Dankher OP, Li Y, Balish RS, Kim R, Heaton A, Marie A. 2003. Phytoremediation strategies for mercury and arsenic pollution. International Applied Phytotechnologies Conference. 2003, Chicago, IL
  • Dhankher OP, Li Y, Rosen BP, Salt D and Meagher RB. Engineered tolerance and hyperaccumulation of arsenic in plants: combining arsenate reductase and g-glutamylcysteine synthetase.  9th New Physiologist Symposium. Heavy metals and plants from ecosystems to biomolecules. University of Pennsylvania, Philadelphia, PA, USA, September 29 - 0ctober 1, 2002
  • Szulwach K, Li X, Smrt R, Li Y, Lin L, Santistevan N, Luo Y, Li W, Zhao X, Jin P. 2008. Integrative epigenetic regulation via MeCP2 mediated control over microRNA-137 in a mouse model of Rett Syndrome. Abstract #231.  58th American Society of Human Genetics Annual Meeting. 2008, Philadelphia, Pennsylvania

 

 

 

 

Yujing Li

Senior Scientist

 


  • DEPARTMENTFaculty at Research Track
    Department of Human Genetics
    Emory University School of Medicine
  • COUNTRY USA