Publications

  • Amborski RL, Glorioso JC.   The frog revisited.  Science 181:495, 1973.
  • Amborski GF, Amborski RL, Glorioso JC.  Factors influencing the bacterial disease of poikilothermic aquaticanimals.  Proceedings of the Gulf Coast Regional Symposium of Disease of Aquatic Animals, p. 19-33, 1974.
  • Glorioso JC, Amborski RL.  The use of antibiotics and dimethylsulfoxide in the treatment of diseased bullfrog tadpoles, Rana catesbeiana.  Proceedings of the Gulf Coast Regional Symposium on Disease of Aquatic Animals, 205-216, 1974.
  • Amborski RL, Glorioso JC, Amborski GF. Development of an organ culture system for the study of an invasive gram positive organism infecting bullfrogs, Rana catesbeiana.  Proceedings of the Gulf Coast Regional Symposium on Disease of Aquatic Animals, p. 217-224, 1974.
  • Glorioso JC, Amborski RL, Larkin JM, Amborski GF, Culley DC.  Laboratory identification of bacterial pathogens in aquatic animals.  Am. J. Vet. Res. 35:447-450, 1974.
  • Glorioso JC, Amborski RL, Amborski GF, Culley DD. Microbiological studies on septicemic bullfrogs (Rana catesbeiana).  Am. J. Vet. Res. 35:1241-1245, 1974.
  • Amborski RL, Glorioso JC, Amborski GF. Common potential pathogens of crayfish, frogs and fish.  In Freshwater Crayfish, papers from the Second International Symposium for Freshwater Crayfish.  James W. Avault, Jr. (ed.) Louisiana State University, Division of Continuing Education, Baton Rouge, LA 70803, p. 317-326, 1975.
  • Smith JW, Glorioso JC.  Effect of cross-immunization on monotypic antibody responses to herpes simplex virus types 1 and 2.  J. Immunol. 116:898-904, 1976.
  • Glorioso JC, Smith JW.  Immune interaction with cells infected with herpes simplex virus: antibodies to radioiodinated surface antigens. J. Immunol. 118:114-121, 1977.
  • Smith JW, Glorioso JC.  A simple method for measuring radioactivity in autoradiograms of polyacrylamide gels.  Int. J. Appl. Radiat. Isot. 28:693-700, 1977.
  • Cossman J, Glorioso JC, Adler R.  Complement receptors: specific detection by molecular complexes.  J. Immunol. Methods 19:227-234, 1978.
  • Adler R, Glorioso JC, Levine M.  Infection by herpes simplex virus and cells of nervous system origin: characterization of a non-permissive interaction.  J. Gen. Virol. 39:9-20, 1978.
  • Glorioso JC, Wilson LA, Fenger TW, Smith JW.  Complement mediated cytolysis of HSV-1 and HSV-2 infected cells: plasma membrane antigens reactive with type-specific and cross-reactive antibody. J. Gen. Virol. 40:443-454, 1978.
  • Adler R, Glorioso JC, Cossman J, Levine M.  Possible role of Fc receptors on cells infected and transformed by herpesvirus: escape from immune cytolysis.  Infect. Immun. 21:442-447, 1978.
  • Hofing GL, Rush HG, Petkus AR, Glorioso JC.  In vitro killing of Pasteurella multocida: the effect of rabbit granulocyte and specific antibody source.  Am. J. Vet. Res. 40:679-683, 1979.
  • Petkus AR, Ringler DH, Rush HG, Glorioso JC.  Experimental chronic Pasteurella multocida infection of subcutaneous chambers in rabbit.  Lab. Anim. Sci. 29:749-754, 1979.
  • Glorioso JC, Levine M, Holland T, Szczesiul M.  Mutant analysis of herpes simplex virus induced cell surface antigens: resistance to complement-mediated immune cytolysis.  J. Virol. 35:672-681, 1980.
  • Levine M, Goldin AL, Glorioso JC.  Persistence of herpes simplex virus genes in cells of neuronal origin.  J. Virol. 35:203-210, 1980.
  • Doepel FM, Glorioso JC, Newcomer CE, Skinner M, Abrams GD. Enzyme-linked immunosorbent assay of serum protein SSA in Rhesus monkeys with secondary amyloidosis.  Lab. Invest. 45:7-13, 1981.
  • Rush HG, Glorioso JC, DaRif C, Olson L.  Resistance of Pasteurella multocida to rabbit neutrophil phagocytosis and killing.  Am. J. Vet. Res. 42:1760-1768, 1981.
  • Sandri-Goldin RM, Levine M, Glorioso JC.  Method for induction of mutations in physically defined regions of the herpes simplex virus genome.  J. Virol. 38:41-49, 1981.
  • Goldin AL, Sandri-Goldin RM, Levine M, Glorioso JC.  Cloning of herpes simplex virus type 1 sequences as representing the whole genome.  J. Virol. 38:50-58, 1981.
  • Jaslow BL, Ringler DH, Rush HG, Glorioso JC.  Pasteurella-associated rhinitis of rabbits: efficacy of penicillin therapy.  Lab. Anim. Sci. 31:382-385, 1981.
  • Sandri-Goldin RM., Levine M, Glorioso JC.  High frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.  Mol. Cell. Biol. 1:743-752, 1981.
  • Glorioso JC, Jones G, Rush HG, Pentler L, DaRif C, Coward JE.  Adhesion of type A Pasteurella multocida to rabbit pharyngeal cells and its possible role in rabbit respiratory tract infections.  Infect. Immun. 35:1103-1109, 1982.
  • Holland TC, Marlin SD, Levine M, Glorioso JC.  Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies.  J. Virol. 45:672-682, 1983.
  • Glorioso J, Szczesiul M, Marlin S, Levine M.  Inhibition of glycosylation of herpes simplex virus glycoproteins: Identification of antigenic and immunogenic partially glycosylated glycopeptides on the cell surface membrane.  Virology 126:1-18, 1983.
  • Sandri-Goldin RM, Goldin A, Levine M, Glorioso JC.  High-efficiency transfer of DNA into eukaryotic cells by protoplast fusion. Meth. Enzymol. 101:402-411, 1983.
  • Schroder CH, Kumel G, Glorioso JC, Kirchner H, Kaerner HC. Neuropathogenicity of HSV in mice: protection against lethal encephalitis by coinfection with a nonencephalitogenic strain.  J. Gen. Virol.  64:1973-1982, 1983.
  • Sandri-Goldin RM, Goldin AL, Holland LE, Levine M, Glorioso JC.  Expression of herpes simplex virus a and l genes integrated in mammalian cells and their induction by a gene product.  Mol. Cell. Biol. 3:2028-2044, 1983.
  • Bishop GA, Glorioso JC, Schwartz SA.  Relationship between expression of herpes simplex virus glycoproteins and susceptibility of target cells to human natural killer activity.  J. Exp. Med. 157:1544-1561, 1983.
  • Holland TC, Sandri-Goldin RM, Holland LE, Marlin SD, Levine M, Glorioso JC.  Physical mapping of the mutation in an antigenic variant of herpes simplex virus type 1 by use of an immunoreactive plaque assay.  J. Virol. 46:649-652, 1983.
  • Bishop GA, Glorioso JC, Schwartz SA.  Role of interferon in human natural killer activity against target cells infected with HSV-1.  J. Immunol. 131:1849-1853, 1983.
  • Anderson LC, Rush HG, Glorioso JC.  Strain differences in the susceptibility and resistance of Pasteurella multocida to phagocytosis and killing by rabbit polymorphonuclear neutrophils.  Am. J. Vet. Res. 45:1193-1198, 1984.
  • Glorioso JC, Schroder CH, Kumel G, Szczesiul MS, Levine M. Immunogenicity of herpes simplex virus glycoproteins gC and gB and their role in protective immunity.  J. Virol. 50:805-812, 1984.
  • Sandri-Goldin RM, Goldin AL, Glorioso JC, Levine M.  Herpes simplex virus thymidine kinase gene is stably maintained and expressed in cells transformed by protoplast fusion.  Somat. Cell Mol. Genet. 10:129-138, 1984.
  • Holland LE, Sandri-Goldin RM, Goldin AL, Glorioso JC, Levine M.  Transcriptional and genetic analyses of the herpes simplex virus type 1 genome:  Coordinates 0.29 to 0.45.  J. Virol. 49:947-959, 1984.
  • Bishop GA, Marlin SD, Schwartz S, Glorioso JC.  Human natural killer cell recognition of herpes simplex virus type 1 glycoproteins: Specificity analysis with the use of monoclonal antibodies and antigenic variants.  J. Immunol. 133:2206-2214, 1984.
  • Holland TC, Marlin SD, Homa F, Levine M, Glorioso JC.  Herpes simplex virus type 1 glycoprotein C negative mutants exhibit multiple phenotypes, including secretion of truncated glycoproteins.  J. Virol. 52:566-574, 1984.
  • Kikuchi G, Coligan J, Holland T, Levine M, Glorioso JC, Nairn R.  Biochemical characterization of peptides from herpes simplex virus glycoprotein gC: loss of CNBr fragments from the carboxy terminus of truncated, secreted gC molecules.  J. Virol. 52:806-815, 1984.
  • Glorioso JC, Kees U, Kumel G, Kirchner H, Krammer P. Identification of herpes simplex virus type 1 (HSV-1) glycoprotein gC as the immunodominant antigen for HSV-1-specific memory cytotoxic T lymphocytes. J. Immunol. 135:575-582, 1985.
  • Goldin AL, Sandri-Goldin RM, Glorioso JC, Levine M.  Stable induction of a 51K cellular protein in neuronal cells surviving herpes simplex virus type 1 infection.  Virology 142:398-405, 1985.
  • Marlin S.D, Holland TC, Levine M, Glorioso JC. Epitopes of herpes simplex virus glycoprotein gC are clustered in two distinct antigenic sites.  J. Virol. 53:128-136, 1985.
  • Kumel G, Kaerner HC, Levine M, Schroder CH, Glorioso JC. Passive immune protection by herpes simplex virus specific monoclonal antibodies and monoclonal antibody resistant mutants altered in pathogenicity.  J. Virol. 56:930-937, 1985.
  • Ross C, Glorioso J, Sacks S, Lavery C, Rawls WE. Competitive inhibition by human sera of mouse monoclonal antibody binding to glycoproteins C and D of herpes simplex virus types 1 and 2.  J. Virol. 54:851-855, 1985.
  • Schroder CH, Dezazzo J, Knopf KW, Kaerner HC, Levine M. Glorioso JC.  A herpes simplex virus type 1 mutant with a deletion in the polypeptide-coding sequences of the ICP4 gene.  J. Gen. Virol. 66:1589-1593, 1985.
  • Bishop GA, Kumel G, Schwartz SA, Glorioso JC.Specificity of human natural killer cells in limiting dilution culture for determinants of herpes simplex virus type 1 glycoproteins.  J. Virol. 57:294-300, 1986.
  • Marlin SD, Highlander SL, Holland TC, Levine M, Glorioso JC. Antigenic variation (Mar mutations) in herpes simplex virus glycoprotein B can induce temperature-dependent alterations in gB processing and replication.  J. Virol. 59:142-153, 1986.
  • Johnson DC, McDermott MR, Chrisp C, Glorioso JC. Pathogenicity in mice of herpes simplex virus type 2 mutants unable to express glycoprotein C.  J. Virol. 58:36-42, 1986.
  • Homa FL, Purifoy DJ, Glorioso JC, Levine M.  Molecular basis of the glycoprotein C-negative phenotypes of herpes simplex virus type 1 mutants selected with a virus-neutralizing monoclonal antibody.  J. Virol. 58:281-289, 1986.
  • Homa FL, Otal TM, Glorioso JC, Levine M.  Transcriptional control signals of a herpes simplex virus type 1 late (g2) gene lie within bases -34 to +124 relative to the 5' terminus of the mRNA.  Mol. Cell. Biol. 6:3652-3666, 1986.
  • Friedman HM, Glorioso JC, Cohen GH, Hastings JC, Harris SL, Eisenberg RJ.  Binding of complement component C3b to glycoprotein gC of herpes simplex virus type 1:  mapping of gC-binding sites and demonstration of conserved C3b binding in low-passage clinical isolates.  J. Virol. 60:470-475, 1986.
  • Black SD, Glorioso JC. MSEQ: a microcomputer-based approach to the analysis, display and prediction of protein structure. Biotechniques 4:448-460, 1986.
  • Weise K, Kaerner HC, Glorioso JC, Schroder CH.  Replacement of glycoprotein B gene sequences in herpes simplex virus type 1 strain ANG by corresponding sequences of the strain KOS causes changes of plaque morphology and neuropathogenicity.  J. Gen. Virol. 68:1909-1919, 1987.
  • Sjoblom I, Lundstrom M, Sjogren-Jansson E, Glorioso JC, Jeansson S, Olofsson S.  Demonstration and mapping of highly carbohydrate-dependent epitopes in the herpes simplex virus type 1-specified glycoprotein C.  J. Gen. Virol. 68:545-554, 1987.
  • Bishop GA, McCurry L, Schwartz JA, Glorioso JC.  Activation of human natural killer cells by herpes simplex virus type 1-infected cells.  Intervirology 28:78-88, 1987.
  • Kikuchi GE, Baker SA, Merajver SD, Coligan JE, Levine M, Glorioso JC, Nairn, R.  Purification and structural characterization of herpes simplex virus glycoprotein C.  Biochemistry 26:424-431, 1987.
  • Robbins AK, Dorney DJ, Wathen MW, Whealy ME, Gold C, Watson RJ, Holland LE, Weed SD, Levine M, Glorioso JC, Enquist L.  The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus.  J. Virol. 61:2691-2701, 1987.
  • Shapira M, Homa FL, Glorioso JC, Levine M. Regulation of the herpes simplex virus type 1 late (g2) glycoprotein C gene: sequences between base pairs -34 to +29 control expression and responsiveness to transactivation by the products of the immediate early (a) 4 and 0 genes. Nucleic Acids Res. 15:3097-3111, 1987.
  • Weber PC, Levine M, Glorioso JC. Rapid identification of nonessential genes of herpes simplex virus type 1 by Tn5 mutagenesis. Science 236:576-579, 1987.
  • Highlander SL, Sutherland SL, Gage PJ, Johnson DC, Levine M, Glorioso JC.  Neutralizing monoclonal antibodies specific for herpes simplex virus glycoprotein D inhibit virus penetration. J. Virol. 61:3356-3364, 1987.
  • Sunstrum JC, Chrisp CE, Levine M, Glorioso JC.  Pathogenicity of glycoprotein C negative mutants of herpes simplex virus type 1 for the mouse central nervous system.  Virus Res. 11:17-32, 1988.
  • Homa FL, Glorioso JC, Levine M.  A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene.  Genes Dev. 2:40-53, 1988.
  • Highlander SL, Cai WH, Person S, Levine M, Glorioso JC. Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration.  J. Virol. 62:1881-1888, 1988.
  • Huff V, Cai W, Glorioso JC, Levine M.  The carboxy-terminal 41 amino acids of herpes simplex virus type 1 glycoprotein B are not essential for production of infectious virus particles.  J. Virol. 62:4403-4406, 1988.
  • Muggeridge MI, Isola VJ, Byrn RA, Tucker TJ, Minson AC, Glorioso JC, Cohen GH, Eisenberg RJ.  Antigenic analysis of a major neutralization site of herpes simplex virus glycoprotein D using deletion mutants and monoclonal antibody-resistant mutants. J. Virol. 62:3274-3280, 1988.
  • Weber PC, Levine M, Glorioso JC.  Simple assay for quantitation of Tn5 inversion events in Escherichia coli and use of the assay in determination of plasmid copy number.  J. Bacteriol. 170:4972-4975, 1988.
  • Weber PC, Challberg MD, Nelson NJ, Levine M, Glorioso JC.  Inversion Events in the HSV-1 genome are directly mediated by the viral DNA replication machinery and lack sequence specificity.  Cell 54:369-381, 1988.
  • Vincent ME, Glorioso JC.  Evaluation of vacuum/suction safety devices in preventing transmission of human virus pathogens.  Amer. Clin. Laboratories, January 1989.
  • Highlander SL, Dorney DJ, Gage PJ, Holland TC, Cai W, Person S, Levine M, Glorioso JC.  Identification of mar mutations in herpes simplex virus type 1 glycoprotein B which alter antigenic structure and function in virus penetration.  J. Virol. 63:730-738, 1989.
  • Chrisp CE, Sunstrum JC, Averill DR, Levine M, Glorioso JC. Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence.  Lab. Invest. 60:822-830, 1989.
  • Hendricks RL, Tao MS, Glorioso JC.  Alterations in the antigenic structure of two major HSV-1 glycoproteins, gC and gB, influence immune regulation and susceptibility to murine herpes keratitis.  J. Immunol. 142:263-269, 1989.
  • Hidaka Y, Kelley WN, Levine M, Glorioso JC.  Expression of human hypoxanthine guanine phosphoribosyltransferrase mRNA in brains of mice infected with a recombinant herpes simplex type 1.  Tran. Assoc. Am. Physicians 102:91-100, 1989.
  • Pallela TD, Hidaka Y, Silverman LJ, Levine M, Glorioso JC, Kelley WN.  Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector.  Gene 80:137-144, 1989.
  • Weber PC, Levine M, Glorioso JC.  A rapid and sensitive method for plasmid copy number comparisons.  Nucleic Acids Res. 17:5866, 1989.
  • Weber PC, Levine M, Glorioso JC.  Recombinogenic properties of herpes simplex virus type 1 DNA sequences resident in simian virus 40 minichromosomes.  J. Virol.  64:300-306, 1990.
  • Wu CT, Levine M, Homa F, Highlander SL, Glorioso JC.  Characterization of the antigenic structure of herpes simplex virus type 1 glycoprotein C through DNA sequence analysis of monoclonal antibody-resistant mutants.  J. Virol. 64:856-863, 1990.
  • Kikuchi GE, Glorioso JC, Nairn R.  Cross-linking studies show that herpes simplex virus type 1 glycoprotein C molecules are clustered in the membrane of infected cells.  J. Gen. Virol. 71:455-458, 1990.
  • Langeland N, Øyan AM, Marsden HS, Cross A, Glorioso JC, Moore LJ, Haarr L.  Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.  J. Virol. 64:1271-1277, 1990.
  • Kimmel KA, Dolter KE, Toth GM, Levine M, Glorioso JC.  Serologic type conversion of a herpes simplex virus type 1 (HSV-1) to HSV-2 epitope caused by a single amino acid substitution in glycoprotein C.  J. Virol. 64:4033-4036, 1990.
  • Mester JC, Highlander SL, Osmand AP, Glorioso JC, Rouse BT.  Herpes simplex virus type 1 specific immunity induced by peptides corresponding to an antigenic site of glycoprotein B.  J. Virol. 64:5277-5283, 1990.
  • Levine M, Krikos A, Glorioso JC, Homa FL.  Regulation of expression of the glycoprotein genes of herpes simplex virus type 1 (HSV-1).  Adv. Exp. Med. Biol. 278:151-164, 1990.
  • Muggeridge MI, Wu TT, Johnson DC, Glorioso JC, Eisenberg RJ, Cohen GH.  Antigenic and functional analysis of a neutralization site of HSV-1 glycoprotein D. Virology 174:375-387, 1990.
  • Olofsson S, Sjoblom I, Glorioso JC, Jeansson S, Datema R. Selective induction of discrete epitopes of herpes simplex virus type 1- specified glycoprotein C by interference with terminal steps in glycosylation.  J. Gen. Virol. 72:1959-1965, 1991.
  • Hendricks RL, Weber P, Taylor JL, Koumbis A, Tumpey TM, Glorioso JC.  Endogenously produced interferon a protects mice from herpes simplex virus type l corneal disease.  J. Gen. Virol. 72:1601-1610, 1991.
  • Highlander SL, Goins WF, Person S, Holland TC, Levine M, Glorioso JC. Oligomer formation of the gB glycoprotein of herpes simplex virus type 1.  J. Virol. 65:4275-4283, 1991.
  • Mester JC, Glorioso JC, Rouse BT.  Protection against zosteriform spread of herpes simplex virus by monoclonal antibodies.  J. Inf. Dis. 163:263-269, 1991.
  • Hoffman EP, Glorioso JC.  Gene therapy: rationale and possible application to Duchenne muscular dystrophy.  Acta Cardiomyologica 3:315-329, 1991.
  • Sjoblom I, Glorioso JC, Sjogren-Jansson E, Olofsson S.  Antigenic structure of the herpes simplex virus type 1 glycoprotein C: demonstration of a linear epitope situated in an environment of highly conformation-dependent epitopes.  APMIS 100:229-236, 1992.
  • Fink DJ, Sternberg LR, Weber PC, Mata M, Goins WF, Glorioso JC.In vivo expression of ß-galactosidase in hippocampal neurons by HSV-mediated gene transfer.  Hum. Gene Ther. 3:11-19, 1992.
  • Dolter KE, Goins WF, Levine M, Glorioso JC.  Genetic analysis of type-specific antigenic determinants of herpes simplex virus glycoprotein C.  J. Virol. 66:4864-4873, 1992.
  • Bandara G, Robbins PD, Georgescu HI, Mueller GM, Glorioso JC, Evans CH.  Gene transfer to synoviocytes: prospects for gene treatment of arthritis.  DNA Cell Biol. 11:227-231, 1992.
  • Gage PJ, Sauer B, Levine M, Glorioso JC.  A cell-free recombination system for site-specific integration of multigenic shuttle plasmids into the HSV-1 genome.  J. Virol. 66:5509-5515, 1992.
  • Evans CH, Bandara G, Mueller G, Robbins P, Glorioso JC, Georgescu HI.  Synovial cell transplants for gene transfer to joints.  Transplant. Proc. 24:2966, 1992.
  • Glorioso JC, Goins WF, Fink DJ.  Herpes Simplex Virus Based Vectors.  Sem. Virol., 3:265-276, 1992.
  • Desai P, DeLuca NA, Glorioso JC, Person S.  Mutations in herpes simplex virus type 1 genes encoding VP5 and VP23 abrogate capsid formation and cleavage of replicated DNA.  J. Virol. 67:1357-1364, 1993.
  • Gage PJ, Levine M, Glorioso JC.  Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B.  J. Virol. 67:2191-2201, 1993.
  • Oyan AM, Dolter KE, Langeland N, Goins WF, Glorioso JC, Haarr L, Crumpacker CS.  Resistance of herpes simplex virus type 2 to neomycin maps to the N-terminal portion of glycoprotein C.  J. Virol. 67:2434-2441, 1993.
  • Goins WF, Sternberg LR, Croen KD, Krause PR, Hendricks RL, Fink DJ, Straus SE, Levine M, Glorioso JC.   A novel latency-active promoter is contained within the herpes simplex virus type l UL flanking repeats. J. Virol. 68:2239-2252, 1994.
  • Desai P, ramakrishnan R, Lin ZW, Osak B, Glorioso JC, Levine M.  The RR1 gene of herpes simplex virus type 1 is uniquely transactivated by ICP0 during infection.  J. Virol. 67:6125-6135, 1993
  • Bandara G, Mueller GM, Galea-Lauri, J., Tindal MH, Georgescu HI, Suchanek MK, Hung, GL, Glorioso JC, Robbins PD, Evans CH.  Intra-articular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc. Natl. Acad. Sci. USA 90:10764-10768, 1993.
  • Ramakrishnan R, Fink DJ, Jiang G, Desai P, Glorioso JC, Levine M.  Competitive quantitative polymerase chain reaction (PCR) analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J. Virol. 68:1864-1873, 1994.
  • Trybala E, Bergstrom T, Svennerholm B, Jeansson S, Glorioso JC, Olofsson S.  Localization of a functional site on herpes simplex virus type 1 glycoprotein C involved in binding to cell surface heparan sulfate.  J. Gen. Virol. 75:743-752, 1994.
  • Glorioso JC, Goins WF, Meaney CA, Fink DJ, DeLuca NA.  Gene transfer to brain using herpes simplex virus vectors.  Ann.Neurol. 35:S28-S34, 1994.
  • Desai P, Homa FL, Person S, Glorioso JC.  A genetic selection method for the transfer of HSV-1 glycoprotein B mutations from plasmid to the viral genome: preliminary characterization of transdominance and entry kinetics of mutant viruses.  Virology 204:312-322, 1994.
  • Glorioso JC, Goins WF, DeLuca NA, Fink DJ.  Development of herpes simplex virus as a gene transfer vector for the nervous system.  Gene Ther. 1:S39, 1994.
  • Glorioso JC, Goins WF, Fink DJ, DeLuca NA.  Herpes simplex virus vectors and gene transfer to brain.  Dev. Biol. Stand. 82:79-87, 1994.
  • Chase GA, DeLeon PA, Dronamraju KR, Erickson RP, Glorioso JC, Hirschhorn R, Lysaught MT, McGraw KM, Meyers AS, Miller AD, Ross GS, Rothenberg KJ, Saha BK, Secundy MD, Straus SE.  Regulation of human gene therapy letter.  Science 269:14-15, 1995.
  • Mester JC, Pitha PM, Glorioso JC.  Anti-viral activity of herpes simplex virus vectors expressing murine alpha-1 interferon.  Gene Ther. 2:187-196, 1995.
  • Glorioso JC, Bender MA, Goins WF, Fink DJ, DeLuca NA.  HSV as a gene transfer vector for the nervous system.  Mol. Biotech. 4:87-99, 1995.
  • Glorioso JC, DeLuca NA, Fink DJ.  Development and application of herpes simplex virus vectors for human gene therapy.  Annu. Rev. Microbiol.  49:675-710, 1995.
  • Glorioso JC.  Gene therapy 1995: developments on the horizon.  Gene Ther. 2:81-83, 1995.
  • Chen X, Schmidt MC, Goins WF, Glorioso JC.  Two herpes simplex virus type-1 latency-active promoters differ in their contribution to latency-associated transcript expression during lytic and latent infection.  J. Virol. 69:7899-7908, 1995.
  • Huard J, Goins WF, Glorioso JC.  Herpes simplex virus type 1 vector mediated gene transfer to muscle. Gene Ther. 2:385-393, 1995.
  • Fink DJ, Ramakrishnan R, Marconi P Goins WF,Holland TC, Glorioso JC.  Advances in the development of herpes simplex virus-based gene transfer vectors for the nervous system.  Clin. Neurosci. 3:284-291, 1995.
  • Fink DJ, DeLuca NA, Goins WF, Glorioso JC.  Gene transfer to neurons using herpes simplex virus-based vectors.  Annu. Rev. Neurosci.  19:265-287, 1996.
  • Laquerre S, Person S, Glorioso JC. Glycoprotein B of herpes simplex virus type 1 oligomerizes through the intermolecular interaction of a 28-amino-acid domain. J. Virol. 70:1640-1650, 1996.
  • Rasty S, Thatikanta P, Gordon J, Khalili K, Amini S, Glorioso JC.  Human immunodeficiency virus tat gene transfer to the murine central nervous system using a replication-defective herpes simplex virus vector stimulates transforming growth factor beta 1 gene expression.  Proc. Natl. Acad. Sci. USA 93:6073-6078, 1996.
  • Oligino T, Poliani PL, Marconi P, Bender MA, Schmidt MC, Fink DJ, Glorioso JC.  In vivo transgene activation from an HSV-based gene vector by GAL4:VP16. Gene Ther. 3:892-899, 1996.
  • Ramakrishnan R, Poliani PL, Levine M, Glorioso JC, Fink DJ.  Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglion by in situ reverse transcriptase PCR. J. Virol. 70:6519-6523, 1996.
  • Marconi P, Krisky D, Oligino T, Poliani PL, Ramakrishnan R, Goins WF, Fink DJ, Glorioso JC. Replication-defective HSV vectors for gene transfer in vivo.  Proc. Natl. Acad. Sci. USA 93:11319-11320, 1996.
  • French S.W, Schmidt MC, Glorioso JC.  Involvement of a high-mobility-group protein in the transcriptional activity of the herpes simplex virus latency-active promoter 2.  Mol. Cell. Biol. 16:5393-5399, 1996.
  • Huard J, Feero WG, Watkins SC, Hoffman EP, Rosenblatt DJ, Glorioso JC.  The basal lamina is a physical barrier to viral mediated gene delivery to mature muscle fibers. J. Virol. 70:8117-8123, 1996.
  • Soares K, Hwang DY, Ramakrishnan R, Schmidt MC, Fink DJ, Glorioso JC.Cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo.  J. Virol., 70:5384-5394, 1996.
  • Evans CH, Robbins PD, Ghivizzani SC, Herndon JH, Kang R, Bahnson AB, Barranger JA, Elders EM, Gay S, Tomaino MM, Wasko MC, Watkins SC, Whiteside TL, Glorioso JC, Lotze MT, Wright TM.  Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis.  Hum. Gene. Ther. 7(10):1261-1280, 1996.
  • Rasty S, Poliani PL, Fink DJ, Glorioso JC. Deletion of the S component inverted repeat sequence c' and the nonessential genes Us1 through Us5 from the herpes simplex virus type 1 genome substantially impairs productive viral infection in cell culture and pathogenesis in the rat central nervous system. J. NeuroVirol. 3:247-264, 1997.
  • Goins WF, Kirsky D, Marconi P, Oligino T, Ramakrishnan R, Poliani PL, Fink DJ, Glorioso JC.  Herpes simplex virus vectors for gene transfer to the nervous system.  J. NeuroVirol. 3(supp. 1):S80-S88, 1997.
  • Huard J, Akkaraju GR, Watkins SC, Pike-Cavalcoli, Glorioso JC.LacZ gene transfer to skeletal muscle using a replication defective herpes simplex virus type 1 mutant vector.  Hum. Gene Ther. 8:439-452, 1997.
  • Fink DJ, Poliani PL, Oligino T, Krisky DM, Goins WF, Glorioso JC.  Development of an HSV-based vector for the treatment of Parkinson's disease. Exper. Neurol. 144, 103-121, 1997.
  • Fink DJ, Glorioso JC.  Engineering herpes simplex virus for gene transfer to neurons.  Nat. Med. 3(3):357-359, 1997.
  • Fink DJ, Glorioso JC.  Herpes simplex virus-based vectors: problems and some solutions.  Adv. Neurol.  72:149-156, 1997.
  • Feero WG, Rosenblatt JD, Huard J, Watkins SC, Epperly M, Clemens PR, Kochanek S, Glorioso JC, Patridge TA, Hoffman EP.  Viral gene delivery to skeletal muscle: insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors.  Hum. Gene Ther. 8(4):371-380, 1997.
  • Evans C, Goins WF, Schmidt MC, Robbins PD, Ghivizzani SC, Oligino T, Marconi P, Krisky D, Glorioso JC. Progress in development of herpes simplex virus gene vectors for treatment of rheumatoid arthritis. Adv. Drug Deliv. Rev. 27:41-57, 1997.
  • Krisky D, Marconi P, Oligino T, Rouse R, Schmidt MC, Glorioso JC.  Rapid method of recombinant HSV gene transfer vectors. Gene Ther. 4:1120-1125, 1997.
  • Huard J, Krisky D, Oligino T, Marconi P, Day CS, Watkins SC, Glorioso JC.  Gene transfer to muscle using herpes simplex virus-based vectors.  Neuromuscular Disorders. 7(5):299-313, 1997.
  • Kuklin NA, Daheshia M, Marconi PC, Krisky DM, Rouse RJ, Glorioso JC, Manickan E, Rouse BT.  Modulation of mucosal and systemic immunity by enteric administration of nonreplicating herpes simplex virus expressing cytokine.  Virology 240:245-253, 1998.
  • Oligino T, Poliani PL, Wang Y, Tsai SY, O'Malley BW, Glorioso JC. Drug inducible transgene expression in brain using a herpes simplex virus vector. Gene Ther. 5(4):491-496, 1998.
  • Kang W, Wilson MA, Bender MA, Glorioso JC, Wilson SP.  Herpes virus-mediated preproenkephalin gene transfer to the amygdala is antinociceptive.  Brain Res. 792:133-135, 1998.
  • Soares MK, Goins WF, Glorioso JC, Fink DJ.  Gene transfer to the nervous system using HSV vectors.  Gene Ther. Mol. Biol.  1:215-229, 1998.
  • Van Deutekom JC, Floyd SS, Booth DK, Oligino T, Krisky D, Marconi P, Glorioso JC,  Huard J.  Implications of maturation for viral gene delivery to skeletal muscle.  Neuromuscul. Disord. 8(3-4):135-148, 1998.
  • Laquerre S, Anderson DB, Argnani R, Glorioso JC.  Herpes simplex virus type 1 glycoprotein B requires a cysteine residue at position 633 for folding, processing and incorporation into mature infectious virus particles.  J. Virol. 72(6):4940-4949, 1998.
  • Laquerre S, Argnani R, Anderson DB, Zucchini S, Manservigi R, Glorioso JC.  Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C which differ in their contribution to virus attachment, penetration, and cell-to-cell spread.  J. Virol. 72(7):6119-6130, 1998.
  • Krisky DM, Marconi PC, Oligino TJ, Rouse RJD, Fink DJ, Cohen JB, Glorioso JC.  Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications.  Gene Ther. 5:1517-1530, 1998.
  • Krisky DM, Wolfe D, Goins WF, Marconi PC, Ramakrishnan R, Mata M, Rouse RJD, Fink DJ, Glorioso JC.  Deletion of Multiple immediate early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. Gene Ther. 5:1593-1603, 1998.
  • Laquerre S, Anderson DB, Stolz DB, Glorioso JC. Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor bearing cells. J. Virol. 72:9683-9697, 1998.
  • Goins WF, Lee KA, Cavalcoli JD, O’Malley ME, DeKosky ST, Fink DJ, Glorioso JC.  Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglia neurons from peroxide toxicity.  J. Virol. 73:519-532, 1999.
  • Moriuchi S, Oligino T, Krisky D, Marconi P, Fink D, Cohen J, Glorioso JC.  Enhanced tumor-cell killing in the presence of ganciclovir by HSV-1 vector-directed co-expression of human TNF-a and HSV thymidine kinase. Cancer Res. 71:278-287, 1998.
  • Wang M, Rancourt C, Navarro JG, Krisky D, Marconi P, Oligino T, Alvarez RD, Siegal GP, Glorioso JC, Curiel DT.  High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.  Gyne. Onc. 71:278-287, 1998.
  • Suzuki T, Piche A, Kasono K, Xiang J, Gomez-Navarro J, Moriuchi S, Krisky DM, Oligino T, Glorioso JC, Curiel TJ, Curiel DT.  Efficient gene delivery into Epstein-Barr virus (EBV) transformed human B cells mediated by replication-defective herpes simplex virus-1 (HSV-1): A gene therapy model for EBV-related B cell malignancy.  Biochem. Biophys. Res. Commun. 252:686-690, 1998.
  • Whalen JD, Lechman EL, Carlos CA, Weiss K, Koveski I, Glorioso JC, Robbins PD, Evans CH.  Adenoviral transfer of the viral IL-10 gene peri-articularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws.  J. Immunol.  162:3625-3632, 1999.
  • Glorioso JC  Handling Herpesvirus.  Book Review of: Herpes simplex virus protocols. Trends in Microbiol. 7(1):51-52, 1999.
  • Marconi P, Simonato M, Zucchini S, Bregola G, Argnani R, Krisky D, Glorioso JC, Manservigi R.  Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer and in vivo.  Gene Ther. 6:904-912, 1999.
  • Wilson SP, Yeomans DC, Bender MA, Lu Y, Goins WF, Glorioso JC.  Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc. Natl. Acad. Sci. USA 96(6):3211-3216, 1999.
  • Alvira MR, Cohen JB, Goins WF, Glorioso JC.  Genetic studies exposing the splicing events involved in herpes simplex virus 1 latency-associated transcript production during lytic and latent infection.  J. Virol.  73(5):3866-3876, 1999.
  • Yamada M, Oligino T, Mata M, Glorioso JC, Fink DJ.  HSV vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine induced degeneration of neurons in the substantia nigra in vivo.  Proc. Natl. Acad. Sci. USA 96(7):4078-4083, 1999.
  • Akkaraju GR, Huard J, Hoffman EP, Goins WF, Pruchnic R, Watkins SC, Cohen JB, Glorioso JC.  Herpes Simplex Virus Vector-Mediated Dystrophin Gene Transfer and Expression in MDX Mouse Skeletal Muscle.  J. Gene Med. 1:280-289, 1999.
  • Wolfe D, Goins WF, Yamada M, Moriuchi S, Krisky DM, Oligino TJ, Marconi PC, Fink DJ, Glorioso JC.  Engineering herpes simplex virus vectors for CNS applications.  Exper Neurol. 159:34-46, 1999.
  • Oligino T, Ghivizzani SC, Wolfe D, Lechman ER, Krisky D, Mi Z, Evans CH, Robbins PD, Glorioso JC. Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis.  Gene Ther. 6(10):1713-1720, 1999.
  • Lemoine N, Glorioso J.  Gene Therapy for the millenium: in with the new.  Gene Ther 6(7):1199, 1999.
  • Simonato M, Marconi P, Glorioso JC, Manservigi R.  Molecular analysis of behavior by gene transfer into neurons with herpes simplex vectors.  Brain Res.  835(1):37-45, 1999.
  • Schmidt MC, Glorioso JC.  Book Review of:  Gene Therapy of Cancer.  Gene Ther. 6:1904, 1999.
  • Wolfe D, Goins WF, Fink DJ, Glorioso JC. Herpes simplex virus vectors for gene therapy.  Gene Therapy: Therapautic Mechanisms and Strategies, N. Smyth Templeton and D.D. Lasic (eds.), Marcel Dekker, Inc 103-129, 1999
  • Marconi P, Tamura M, Moriuchi S, Krisky DM, Goins WF, Cohen JB, Glorioso JC.  Connexin43-enhanced suicide gene therapy using herpesviral vectors.  Mol. Ther. 1:71-81, 2000.
  • Gomez-Navarro J, Contreras JL, Arafat W, Jiang XL, Krisky DM, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM.  Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a Rhesus model.  Gene Ther. 7:43-52, 2000.
  • Anderson DB, Laquerre S, Ghosh K, Ghosh HP, Goins WF, Cohen JB, Glorioso JC.  Pseudotyping of glycoprotein D-deficient herpes simplex virus type 1 with vesicular stomatitis virus glycoprotein G enables mutant virus attachment and entry.  J. Virol. 74(5):2481-2487, 2000.
  • Fink DJ, DeLuca NA, Yamada M, Wolfe DP, Glorioso JC.  Design and application of HSV vectors for neuroprotection.  Gene Ther.  7(2):115-119, 2000.
  • Yao Q, Glorioso JC, Evans CH, Robbins PD, Kovesdi I, Oligino TJ, Ghivizzani SC.  Adenoviral mediated delivery of FAS ligand to arthritic joints cause extensive apoptosis in the synovial lining.  J. Gene Med.  2(3):210-219, 2000.
  • Martino G, Poliani PL, Furlan R, Marconi P, Glorioso JC, Adorini L, Comi G.  Cytokine therapy in immune-mediated demylelinating diseases of the central nervous system: a novel gene therapy approach.  J. Neuroimmunol.  107:184-190, 2000.
  • Simonato M, Manservigi R, Marconi P, Glorioso JC.  Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors.  Trends Neurosci.  23:183-190, 2000.
  • Wechuck JB, Goins WF, Glorioso JC, Ataai MM.  Effect of protease inhibitors on yield of HSV-1 based viral vectors.  Biotechnol. Prog. 16(3):493-496, 2000.
  • Niranjan A, Moriuchi S, Lunsford LD, Kondziolka D, Flickinger JC, Fellows W, Rajendiran S, Tamura M, Cohen JB, Glorioso JC.  Effective treatment of experimental glioblastoma by HSV vector-mediated TNFa and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.  Mol. Ther. 2(2):114-120, 2000.
  • Moriuchi S, Krisky DM, Marconi PC, Tamura M, Shimizu K, Yoshimine T, Cohen JB, Glorioso JC.  HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.  Gene Ther., 7(17):1483-1490, 2000.
  • Ghivizzani SC, Oligino TJ, Glorioso JC, Robbins PD, Evans CH.  Gene therapy approaches for treating rheumatoid arthritis.  Clin Orthop 379(Suppl) S288-299, 2000.
  • Mi Z, Ghivizzani SC, Lechman ER, Jaffurs D, Glorioso JC, Evans CH, Robbins PD. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints.  Arthritis Rheum 43(11): 2563-2570, 2000.
  • Rouse RJD, Seifried W, Mistry SK, Goins WF, Glorioso JC.  Herpes simplex virus enhanced cationic lipid/DNA mediated transfection. Biotechniques 29(4):810-814, 2000.
  • Burton EA, Glorioso JC. Herpes simplex virus vector-based gene therapy for malignant glioma. Gene Ther Mol Biol.  5:1-17, December 2000.
  • Chen, Li J, Mata M, Goss J, Glorioso JC, Fink DJ.  The ICP0 protein of herpes simplex virus 1 does not accumulate in the nucleus of primary neurons in culture. J. Virol. 74(21):10132-10141, 2000.
  • Glorioso JC.  Perspectives on viral vector design and applications.  Adv. Virus Res. 55:403-407, 2000.
  • Glorioso JC, Huang L, Dunbar C, Felgner PL.  Highlights from the third annual ASGT meeting. American Society of Gene Therapy.  Mol. Ther.  2(2):96-100, 2000.
  • Arafat WO, Casado E, Wang, M, Alvarez RD, Siegal GP, Glorioso JC, Curiel DT, Gomez-Navarro J.  Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer cells.  Clin Cancer Res 6 (11):4442-4448, 2000.
  • Poliani PL, Brok H, Furlan R, Ruffini F, Bergami A, Desina G, Marconi PC, Rovaris, M, Glorioso JC, Penna G, Adorini L, Comi G, Hart B, Martino G.  Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis.  Hum. Gene Ther. 12(8):905-920, 2001.
  • Wolfe D, Goins WF, Kaplan TJ, Capuano S, Fradette J, Murphey-Corb M, Robbins PD, Cohen JB, Glorioso JC.  Herpesvirus-mediated systemic delivery of nerve growth factor.  Mol. Ther. 3(1):61-69, 2001.
  • Yamada M, Natsume A, Mata M, Oligino T, Goss JR, Glorioso JC, Fink DJ.  Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion. Exp Neurol, 168(2):225-230, 2001.
  • Kay MA, Glorioso JC, Naldini L.  Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therpeutics.  Nat. Med. 7(1):33-40, 2001.
  • Furlan R, Poliani PL, Marconi PC, Bergami A, Ruffini F, Adorini L, Glorioso JC, Comi G, Martino G.  Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice.  Gene Ther. Jan;8(1);13-19, 2001.
  • Goss JR, Mata M, Goins WF, Wu HH, Glorioso JC, Fink DJ.  Antinociceptive effects of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion.  Gene Ther, 8(7):551-556, 2001.
  • Goins WF, Yoshimura N, Phelan MW, Yokoyama Fraser MO, Ozawa H, T, Bennett N, de Groat WC, Glorioso JC, Chancellor MB.  Herpes simplex virus mediated nerve growth factor expression in bladder and afferent neurons: potential treatment for diabetic bladder dysfunction.  J Urol 165(5):1748-1754, 2001.
  • Burton EA, Glorioso JC.  Multi-modal combination gene therapy for malignant glioma using replication-defective HSV vectors.  Drug Discov Today. Apr 1; 6(7):347-56, 2001.
  • Ghivizzani SC, Oligino TJ, Glorioso JC, Robbins PD, Evans CH.  Direct gene delivery strategies for the treatment of rheumatoid arthritis.  Drug Discov Today. 2001 Mar 1, 6(5):259-67.
  • Mardberg K, Trybala E, Glorioso JC, Bergstrom T.  Mutational analysis of the major heparan sulfate-binding domain of herpes simplex virus type 1 glycoprotein C.  J Gen Virol. Aug; 82(Pt8); 1941-50, 2001.
  • Natsume A, Mata M, Goss J, Huang S, Wolfe D, Oligino T, Glorioso JC, Fink DJ.  Bcl-2 and GDNF delivered by HSV-meidated gene transfer act additively to protect dopaminergic neurons from 6-OHDA induced degeneration.  Exp Neurol. 169:231-238, 2001.
  • Yao Q, Wang S, Glorioso JC, Evans CH, Robbins PD, Ghivizzani SC, Oligino TJ.  Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.  Mol Ther. Jun; 3(6):901-10, 2001.
  • Burton EA, Wechuck JB, Wendell SK, Goins WF, Fink DJ, Glorioso JC.  Multiple applications of replication-defective herpes simplex virus vectors.  Stem Cells 19 (5):358-7, 2001.
  • Burton EA, Bai Q, Goins WF, Glorioso JC.  Targeting gene expression using HSV vectors.  Adv Drug Deliv Rev. Dec 17; 53(2):155-70, 2001.
  • Yoshimura N, Franks ME, Sasaki K, Goins WF, Goss J, Yokoyama T, Fraser MO, Seki S, Fink J, Glorioso JC, de Groat WC, Chancellor MB.  Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE).  Urology 57(6 suppl 1):116, 2001.
  • Ruffini F, Furlan R, Poliani. PL, Brambilla E, Marconi PC, Bergami A, Desina G, Glorioso JC, Comi G, Martino G.  Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice.  Gene Ther. Aug;8(6):1207-13.
  • Wechuck J, Ozuer A, Goins Wolfe D, Oligino T, Glorioso JC, Ataai M.  Effects of temperature, medium composition and cell passage on production of herpes-based viral vectors. Biotech Bioeng. Jul 5;79(1)112-9, 22002.
  • Ozuer A, Wechuck JB, Goins WF, Wolfe D, Glorioso JC, Ataai M.  Effect of genetic background and culture conditions on production of herpesvirus-based gene therapy vectors. Biotechnol Bioeng. Mar 20;77(6) 685-92, 2002.
  • Chattopadhyay M, Wolfe D, Huang S, Goss J, Glorioso JC, Mata M, Fink DJ.  In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3.  Ann Neurol.  Jan;51(1):19-27, 2002.
  • Natsume A, Mata M, Wolfe D, Oligino T, Goss J, Huang S, Glorioso JC, Fink DJ.  Bcl-2 and GDNF delivered by HSV-mediated gene transfer after spinal root avulsion provide a synergistic effect.  J. Neurotrauma 19(1):61-68, 2002.
  • Iwai M, Harada Y, Ishii M, Kashima K, Mazda O, Tamura M, Wolfe D, Goins WF, Glorioso JC.  Suicide gene therapy of human hepatoma and its peritonitis carcinomatosis by a vector of replicative-deficient herpes simplex virus.  Biochem and Biophys Res Commun. Mar 8-291(14):855-60, 2002.
  • Ozuer A, Wechuck JB, Russell B, Wolfe D, Goins WF, Glorioso JC, Ataai MM.  Evaluation of infection parameters in the production of replication-defective HSV-1 viral vectors.  Biotechnol Prog. May-Jun; 18(3):476482, 2002.
  • Goss JR, Goins WF, Lacomis D, Mata M, Glorioso JC, Fink DJ.  Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse.  Diabetes Jul; 51(7):2227-32, 2002.
  • Chen XP, Mata M, Kelley M, Glorioso JC, Fink DJ.  The relationship of herpes simplex virus latency associated transcript expression to genome copy number: a quantitative study using laser capture microdissection.  J Neurovirol. Jun 8(3):204-10, 2002.
  • Glorioso JC, Fink DJ.  Use of HSV vectors to modify the nervous system.  Curr Opin Drug Discov Devel.  Mar; 5(2):289-95, 2002.
  • Moriuchi S, Wolfe D, Tamura M, Yoshimine T, Miura F, Cohen JB, Glorioso JC.  Double suicide gene therapy using a reciprocal interference in a malignant glioma model.  Gene Ther. May; 9(9):584-91, 2002.
  • Burton EA, Bai Q, Goins WF, Glorioso JC.  Replication-defective genomic herpes simplex vectors: Design and production. Curr Opin Biotechnol. Oct;13(5):424-8, 2002.
  • Burton EA, Fink D, Glorioso JC.  Gene delivery using herpes simplex virus vectors.  DNA Cell Biol.  Dec; 21(12):915-6, 2002.
  • Goss JR, Harley CF, Mata M, O'Malley ME, Goins WF, Hu XP, Glorioso JC, Fink DJ.  Herpes vector-mediated expression of proenkephalin reduces bone cancer pain.  Ann Neurol. Nov; 52(5):662-5, 2002.
  • Mata M, Glorioso JC, Fink DJ.  Targeted gene delivery to the nervous system using herpes simplex virus vectors.  Physiol Behav. Dec;77(4-5):483-8, 2002.
  • Glorioso JC, Lemoine N.  Electronic submission, review and tracking system for gene therapy. 9:1, 2002.
  • Campbell NJ, Lemoine NR, Glorioso JC.  Information overload? Take the ‘Progress and Prospects’ cure.  Gene Ther. Oct; 9(20):1343, 2002.
  • Miura F, Moriuchi S, Maeda M, Sano A, Maruno M, Tsanaclis AM, Marino R, Glorioso JC, Yoshimine T.  Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.  Gene Ther. Dec; 9(24):1653-8, 2002.
  • Goins WF, Krisky DM, Wolfe DP, Fink DJ, Glorioso JC. Development of replication-defective herpes simplex virus vectors.  Methods Mol Med 69:481-507, 2002.
  • Hao S, Mata M, Goins W, Glorioso JC, Fink DJ. Transgene-mediated enkephalin release enhances the effect of   morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain. Pain Mar; 102(1-2):135-42, 2003.
  • Misumi M, Suzuki T, Moriuchi S, Glorioso JC, Bessho M.  In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus-1 against leukemic B-cell malignancies (MCL, HCL, B-CLL).  Leuk Res Aug; 27(8): 695-9, 2003.
  • Burton EA, Hong CS, Glorioso JC.  The stable 2.0kb intron of HSV-1 LAT does not function as a repressor as an antisense repressor of ICP0 in nonneuronal cells. J.Virol. Mar;77(6):3516-30, 2003.
  • Chattopadhyay M, Goss J, Lacomis D, Goins WC, Glorioso JC, Mata M, Fink DJ.  Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals.  Europ J Neurosci  Feb;17(4):732-40, 2003.
  • Burton EA, Glorioso JC, Fink DJ.  Review: Gene therapy progress and prospects: Parkinson’s disease.  Gene Ther. Sep;10(20):1721-7, 2003.
  • Yao Q, Wang S, Gambotto A, Glorioso JC, Evans C H, Robbins PD, Ghivizzani S C, Oligino T J. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene Ther. Jun; 10(12):1055-60, 2003.
  • Mi Z, Ghivizzani SC, Lechman ER, Glorioso JC, Evans CH, Robbins PH.  Adenovirus-mediated gene transfer of human transforming growth factor (TGF)-b1 into rabbit knees induces cartilage degradation.  Arthritis Res Ther 5(3):R132-9, 2003.
  • Kohn DB, Sadelain M, Glorioso JC.  Occurrence of leukaemia following gene therapy of X-linked SCID.  Nature Rev Cancer Jul;3(7):477-88, 2003.
  • Burton EA, Glorioso JC.  Gene therapy for malignant glioma using herpes simplex virus vectors. Recent Research Developments in Cancer.  (4) 139-159 2002.
  • Kohn DB, Sadelain M, Dunbar C, Bodine D, Kiem HP, Candotti F, Tisdale J, Riviere I., Blau CA, Richard RE, Sorrentino B, Nolta J, Malech H, Brenner M, Cornetta K, Cavagnaro J, High K, Glorioso J.  American Society of Gene Therapy (ASGT) Ad Hoc Subcommittee on Retroviral-Mediated Gene Transfer to Hematopoietic Stem Cells.  Mol Ther. 2:180-7, 2003.
  • Fink D, Mata M, Glorioso JC.  Cell and gene therapy in the treatment of pain.  Adv Drug Deliv Rev. Aug 28;558):1055-64, 2003.
  • Hao S, Mata M, Wolfe D, Huang S, Glorioso JC, Fink DJ.  HSV-mediated gene transfer of the glial cell derived neurotrophic factor (GDNF) provides an anti-allodynic effect in neuropathic pain.  Mol Ther. Sep;8(3): 367-75, 2003.
  • Natsume A, Wolfe D, Hu J, Puskovic V, Glorioso JC, Fink DJ, Mata M.  Enhanced functional recovery after proximal nerve root injury by vector-mediated gene transfer.  Exp Neurol. Dec;184(2): 878-86, 2003.
  • Niranjan A, Wolfe D, Tamura M, Soares MK, Krisky DM, Lunsford LD, Li S, Fellows-Mayle W, DeLuca NA, Cohen JB, Glorioso JC.  Treatment of rat gliosarcoma brain tumors by HSV-based multi-gene therapy combined with radiosurgery.  Mol Ther. Oct; 8(4):530-42, 2003.
  • Glorioso JC, Mata M, Fink DJ.  Gene therapy for chronic pain.  Curr Opin Mol Ther.Oct 5(5):483-8, 2003.
  • Burton EA, Huang S, Goins WF, Glorioso JC.  Use of the herpes simplex viral genome to construct gene therapy vectors.  Methods Mol Med. 76:1-31, 2003.
  • Glorioso JC, Mata M, Fink DJ. Therapeutic gene transfer to the nervous system using viral vectors.  J. Neurovirol. 2: 165-72, 2003.
  • Guo HL, Wolfe D, Epperly M, W, Huang S, Liu K, Glorioso JC, Greenberger J, Blumberg D.  Gene transfer of human manganese superoxide dismutase protects small intestinal villi from radiation injury. J. Gastrointest Surgery Feb;7(2);229-35, 2003.
  • Fink DJ, Glorioso JC, Mata M.  Therapeutic gene transfer with herpes-based vectors: studies in Parkinson’s disease and motor nerve regeneration. Exp. Neuro. (184) 1001: 19-24, 2003.
  • Mata M, Glorioso JC, Fink DJ.  Development of HSV-mediated gene transfer for the treatment of chronic pain. Exp.  (184) 1001: 25-29, 2003.
  • Glorioso JC, Mata M Fink D. Exploting the neurotherapeutic potential of peptides: targeted delivery using HSV vectors. Expert Opin. Biol Ther. Dec; 3(8): 1233-9, 2003.
  • Mata M, Glorioso JC, Fink DJ.Gene transfer to the nervous system: prospects for novel treatments directed at diseases of the aging nervous system. J Gerontol A Biol Sci Med Sci. Dec; 58(12):M1111-8 Review, 2003.
  • Chattopadhyay M, Goss J, Wolfe D, Goins WF, Huang S, Glorioso JC, Mata M, Fink DJ. Protective effect of herpes simplex virus-mediated neurotrophin gene transfer in cisplatin neuropathy. Brain Apr;127 (Pt4):929-39, 2004
  • Niranjan A, Wolfe D, Fellows W, Goins WF, Glorioso JC, Kondziolka D, Lunsford LD. Gene   transfer to glial tumors using herpes simplex virus. Methods Mol Bio 246:323-37, 2004.
  • Goins WF, Wolfe D, Krisky DM, Bai Q, Burton EA, Fink DJ, Glorioso JC. Delivery using herpes simplex virus: an overview. Methods Mol. Biol. 246: 257-99, 2004.
  • Goss JR, Natsume A, Wolfe D, Mata M, Glorioso JC, Fink DJ. Delivery of herpes simplex virus- based vectors to the nervous system.  Methods Mol Biol  246:309-22, 2004.
  • Wolfe D, Wechuck JB, Krisky DM, Goff JP, Goins WF, Ozuer A, Epperly ME, Greenberger JS, Fink DJ, Glorioso JC.  Delivery of herpes simplex virus-based vectors to stem cells.  Methods Mol Biol 246:339-52, 2004.
  • Mata M, Glorioso JC, Fink DJ.  Gene therapy: novel treatments for polyneuropathy and chronic pain.    Curr Neurol Neurosci Rep. Rep Jan; 4(1):1-2, 2004.
  • Sasaki K, Chancellor MB, Goins WF,  Phelan MW, Glorioso JC, de Groat WC, Yoshimura N.Gene therapy using replication defective herpes simplex virus vectors expressing nerve growth actor in a rat model of diabetic cystopathy.  Diabetes. Oct 53:2723-30, 2004.
  • Jiang C, Wechuck JB, Goins WF, Krisky DM, Wolfe D, Ataai MM, Glorioso JC.  Immobilized cobalt affinity chromatography provides a novel, efficient method for herpes simplex virus type1gene vector purification. J Virol. Sep.78 (17):8994-9006, 2004.
  • Glorioso JC, Fink DJ.  Herpes vector-mediated gene transfer in treatment of diseases of the nervous system. Annu Rev Microbiol (58): 253-71, Review, 2004.
  • Nakano K, Todo T, Zhao G, Yamaguchi K, Kuroki S, Cohen JB, Glorioso JC, Tanaka M. Enhanced efficacy of conditionally replicating herpes simplex virus (G207) combined with 5-fluorouracil and surgical resection in peritoneal cancer dissemination models. J Gene Med. May; 7(5): 638-48, 2005.
  • Puskovic V, Wolfe D, Goss J, Huang S, Mata M, Glorioso JC, Fink DJ. Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivo. Mol Ther. Jul; 10: 67-75, 2004.
  • Wolfe D, Niranjan A, Trichel A, Wiley C, Ozuer A, Kanal E, Kondziolka D, Krisky D, Goss J, DeLuca NA, Murphey-Corb M, Glorioso JC. Safety and biodistribution studies of an HSV multigene vector following intracranial delivery to non-human primates. Gene Ther. Dec; 11(23): 1675-84, 2004.
  • Liu J, Wolfe D, Hao S, Huang S, Glorioso JC, Mata M, Fink DJ. Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. Mole Ther Jul; 10(1): 57-66, 2004.
  • Fradette J, Wolfe D, Goins WF, Huang S, Flanigan RM, Glorioso JC.  HSV vector-mediated   transduction and GDNF secretion from adipose cells.  Gene Ther. Jan; 12(1), 48-58, 2005.
  • Frampton AR, Goins WF, Cohen JB, Von Einem J, Osterrieder N, O’Callaghan DJ, Glorioso JC. Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.  J.Virology Mar; 79(5): 3169-73, 2005.
  • Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS,  The liver X receptor ligand T0901317 decreases amyloid β production in Vitro and in a mouse model of Alzheimer’s disease.  J. Biol. Chem. Feb 11; 280(6): 4079-88, 2005.
  • Nakano K, Asano R, Tsumoto K, Kwon H, Goins WF, Kumagai I, Cohen JB, Glorioso JC.  Herpes simplex virus targeting to the EGF receptor by a gD-specific soluble bridging molecule.  Mol Ther. Apr; 11(4): 617-26, 2005.
  • Bennett NE, Kim JH, Wolfe DP, Katsumi K, Yoshimura N, Goins WF, Huang S, Nelson JB, deGroat WC, Glorioso JC, Chancellor MB.  Improvement of erectile dysfunction after neurotrophic factor gene therapy in diabetic rats.  J Urol. May; 173(5): 1820-4, 2005.
  • Moriuchi S, Glorioso JC, Maruno M, Izumoto S, Wolfe D, Huang S, Cohen JB, Yoshimine T. Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IKβ and HSV thymidine kinase.  Cancer Gene Ther. 12: 487-96, 2005.
  • Chattopadhyay M, Krisky D, Wolfe D, Glorioso JC, Mata M, Fink DJ.  HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy.Gene Ther. Sep; 12(18): 1377-84, 2005.
  • Frampton AR, Goins WF, Nakano K, Burton EA, Glorioso JC. HSV trafficking and development of gene therapy vectors with applications in the nervous system. Gene Ther. Jun; 12(11): 891-901, 2005.
  • Hao S, Mata M, Wolfe D, Glorioso JC, Fink DJ, Gene transfer of glutamic acid decarboxylaase reduces neuropathic pain.  Ann Neurol. Jun; 5 (6): 914-8, 2005.
  • Burton EA, Fink DJ, Glorioso JC. Replication-defective genomic HSV gene therapy vectors: design production and CNS applications. Curr Opin Mol Ther. Aug; 7(4): 326-336, 2005.
  • Kuwayama Y, Suzuki T, Moriuchi S, Glorioso JC, Bessho M. I kappa B-mediated apoptotic gene therapy against acute myelogenous leukemia using replication-defective HSV-1 vector expressing TK and mutant I kappa B alpha.  Cell Mol Biol. Sep 2; 51(1): 77-86, 2005.
  • Chattopadhyay M, Wolfe, D, Mata M, Huang S, Glorioso JC, Fink, DJ.  Long-term neuroprotection achieved with latency-associated promoter-driven Herpes Simplex Virus gene transfer to the peripheral nervous system. Mol Ther. Aug; 12(2): 307-13, 2005.
  • Kwon H, Bai Q, Baek HJ, Felmet K, Burton EA, Goins WF, Cohen JB, Glorioso JC. Soluble V domain of nectin-1/HveC enables entry of herpes simplex virus type 1 (HSV-1) into HSV-resistant cells by binding to viral glycoprotein D.  J Virol. Jan; 80(1): 138-48, 2006.
  • Hao S, Mata M, Glorioso JC, Fink DJ.  HSV–mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain.  Mol Pain, Feb; 2: 6, 2006.
  • Jiang C, Ataai M, Ozuer A, Wechuck J, Krisky D, Pornsuwan S, Pourarian F, Glorioso JC.   Inactivation of herpes simplex type 1 gene vector on immobilized metal affinity chromatography: oxidative damage by hydroxyl free radicals and its prevention.  Biotechnol Bioeng. Sep 5; 95(1): 48-57, 2006.
  • Jiang C, Glorioso JC, Ataai M. Presence of imidazole in loading buffer prevents formation of free radical in IMAC and dramatically improves the recovery of HSV-1 gene therapy vectors. J Chromatogr A, Jul 14; 112(1): 40-5, 2006.
  • Peng X, Zhou Z, Glorioso JC, Fink DJ, Mata M. Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury. Ann Neurol. May; 59(5): 843-51, 2006
  • Puskovic V, Wechuck JB, Collins J, Glorioso JC, Fink DJ, Marina MD. HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated mice.  Mol. Ther Nov; 14(5): 710-5, 2006.
  • Hong CS, Goins WF, Goss JR, Burton EA, Glorioso JC.  Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer’s disease-related Amyloid-β peptide in vivo.  Gene Ther Jul; 13(14): 1068-79, 2006.
  • Tsvitov M, Frampton Jr, Shah AR, Wendell WA, Ozuer A., Goins WF, Cohen JB, Glorioso JC. Characterization of soluble glycoprotein D-mediated herpes simplex virus type 1 infection. Virology Apr 10; 360(2): 477-91, 2007.
  • Niranjan A, Fellows W , Stauffer W, Burton EA, Hong CS, Lunsford LD, Kondiziolka D, Glorioso JC, Gobbel GT. Survival of transplanted neural progenitor cell enhanced by brain irradiation.  J Neurosurg. Aug; 107(2): 383-91, 2007.
  • Srinivasan R, Huang S, Chaudhry S, Sculptoreanu A, Krisky D, Cascio M, Friedman PA, deGroat WC, Wolfe D, Glorioso JC. An HSV vector system for selection of ligand-gated ion channel modulators. Nat Methods. Sep; 4(9): 733-9, 2007.
  • Frampton AR Jr, Stolz DB, Uchida H, Goins WF, Cohen JB, Glorioso JC.  Equine herpesvirus 1 enters cells by two different pathways and infection requires the activation of the cellular kinase ROCK1. J Virol. Oct; 81(20):10879-89, 2007. Epub 2007 Aug 1. PMCID:PMC2045510
  • Kato R, Wolfe D, Coyle CH, Huang S, Wechuck JB, Goins WF, krisky DM, Tsukamoto T, Nelson JB, Glorioso JC, Chancellor MB, Yoshimura N. Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury. Gene Ther. Sep; 14(18): 1344-52, 2007.
  • Hao S, Mata M, Glorioso JC, Fink DJ.Gene transfer to interfere with TNFalpha signaling in neuropathic pain.  Gene Ther. Jul; 14(13): 1010-6, 2007.
  • Chattopadhyay M, Mata M, Goss J, Wolfe D, Huang S, Glorioso JC, Fink DJ.  Prolonged preservation of nerve function in diabetic neuropathy in mice by herpes simplex virus-mediated gene transfer.
    Diabetologia, Jul; 50(7): 1550-8, 2007.
  • Goss JR, Goins WF, Glorioso JC. Gene therapy applications for the treatment of neuropathic pain.
    Expert Rev Neurother, May; 7(5): 487-506, 2007.
  • Wolfe D, Hao S, Hu J, Srinivasan R, Goss J, Mata M, Fink DJ, Glorioso JC. Engineering an endomorphin-2 gene for use in neuropathic pain therapy. Pain, Dec 15; 133(1-3): 29-38, 2007.
  • McTiernan CF, Mathier MA, Zhu X, Xiao X, Klein E, Swan CH, Mehdi H, Gibson G, Trichel AM, Glorioso JC, Feldman AM, McCurry KR, London B.  Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts. Gene Ther, Dec; 14(23): 1613-22, 2007.
  • Li H, Baskaran R, Krisky D, Bein K, Grandi P, Cohen JB, Glorioso JC. Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. Virology. 2008 May 25;375(1):13-23. PMCID: PMC2706573.
  • Goins WF, Krisky DM, Wechuck JB, Huang S, Glorioso JC. Construction and production of recombinant herpes simplex virus vectors. Methods Mol Biol. 433: 97-113, 2008.
  • Srinivasan R, Fink DJ, Glorioso JC.  HSV vectors for gene therapy of chronic pain.  Curr Opin Mol Ther, Oct; 10(5): 449-55, 2008.
  • SrinivasanR, Wolfe D, Goss JR, Watkins S, deGroat W, Sculptoreanu A, Glorioso JC.PKCε contributes to basal and sensitizing responses of TRPV1 to capsaicin in dorsal root ganglion neurons. Eur J Neurosci Oct; 28(7); 1241-54, 2008.
  • Craft AM, Krisky DM, Wechuck JB, Lobenhofer EK, JiangY, Wolfe D, Glorioso JC. HSV-mediated expression of Pax3 and MyoD in embryoid bodies results in lineage-related alterations in gene expression profiles.  Stem Cells, Dec; 26(12): 3119-29, 2008.
  • Kato R, Wolfe D, Coyle CH, Wechuck JB, Tyagi P, Tsukamoto T, Nelson JB, Glorioso JC, Chancellor MB, Yoshimura N. Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury. Gene Ther, Jan; 16(1): 26-33, 2009. PMID: 18668142
  • .Hao S, Wolfe D, Glorioso JC, Mata M, Fink DJ.  Effects of transgene-mediated endomorphin-2 in inflammatory pain. Eur J Pain, Apr; 13(4): 380-386, 2009. PMID: 18567517
  • Grant K, Krisky D, Ataai MM, Glorioso JC.  Engineering cell lines for production of replication defective HSV-1 gene therapy vectors.  Biotechnol Bioeng, Mar; 102(4): 1087-97, 2009. PMID: 18828174
  • Glorioso JC, Fink DJ. Herpes vector-mediated gene transfer in the treatment of chronic pain.  Mol Ther 17(1): 13-8, 2009. PMID: 18841093
  • Yokoyama H, Sasaki K, Franks ME, Goins WF, Goss JR, deGroat W, Glorioso JC, Chancellor MB,  Yoshimura N. Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin.  Hum Gene Ther. Jan; 20(1): 63-71, 2009. PMID: 20377371
  • Miyazato M, Sugaya K, Goins WF, Goss JR, Chancellor MB, deGroat WC, Glorioso JC, Yoshimura N.  Herpessimplex virus vector-medicated gene delivery of glutamic acid decarboxylase reduces detrusor over-activity in spinal cord injury rats. Gene Ther. May; 16(5): 660-8, 2009.
  • Uchida H, Shah WA, Ozuer A, Frampton AR, Goins WF, Grandi P, Cohen JB, Glorioso JC. Generation of HVEM-restricted HSV-1 mutant viruses: Resistance of HVEM-expressing cells and identification of mutations that rescue nectin-1 recognition. J. Virol. Apr;83(7):2951-61, 2009. PMCID: PMC2655597
  • Goss JR, Gold MS, Glorioso JC.  HSV vector-mediated modification of primary nociceptor afferents: an approach to inhibit chronic pain.  Gene Ther, Apr; 16(4): 493-501, 2009.
  • Goins WF, Goss JR, Chancellor BM, deGroat WC, Glorioso JC, Yoshimura N.  Herpes simplex virus vector-mediated gene delivery for the treatment of lower urinary tract pain. Gene Ther. Apr;16(4):558-69, 2009. PMCID: PMC2732574.
  • Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC. Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother Apr; 9(4): 505-17, 2009. PMCID: PMC3219506.
  • Glorioso JC, Fink DJ.  Gene therapy for pain: introduction to the special issue.  Gene Ther, Apr; 16(4): 453-4, 2009.
  • Wolfe D, Craft AM, Cohen JB, Glorioso JC. An hsv vector system for expression of complex cdna libraries. J. Virol. Jul;84(14):7360-8, 2009. PMC2898265.
  • Yoshimura N, Kato R, Chancellor MB, Nelson JB, Glorioso JC. Gene therapy as future treatment of erectile dysfunction.  Expert Opin Biol Ther. Sep; 10(9): 1305-1314, 2010.
  • Uchida H, Chan J, Goins WF, Grandi P, Kumagai I, Cohen JB, Glorioso JC.A double mutation in gB compensates for ineffective gD-dependent initiation of HSV-1 infection. J Virol. Dec; 84(23):12200-9, 2010. PMCID: PMC2976401.
  • Miyazato M, Sugaya K, Saito S, Chancellor MB, Goins WF, Goss JR, de Groat WC, Glorioso JC,Yoshimura N. Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats.  J Urol. Sep; 184(3): 1204-10, 2010.
  • Hong CS, Fellows W, Niranjan A, Alber S, Watkins S, Cohen JB, Glorioso JC, Grandi P. Ectopic matrix metalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection. Gene Ther. Oct;17(10):1200-5, 2010. PMCID: PMC3228315.
  • Frampton AR Jr, Uchida H, von Einem J, Goins WF, Grandi P, Cohen JB, Osterrieder N, Glorioso JC.Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells. Vet Microbiol. Feb 24;141(1-2):12-21, 2010. PMCID: PMC2819619.
  • Nakano K, Kobayashi M, Nakamura K, Nakanishi T, Asano R, Kumagai I, Tahara H, Kuwano M, Cohen JB, Glorioso JC. Mechanism of HSV infection through soluble adapter-mediated virus bridging to the EGF receptor. Virology. Apr 25;413(1):12-8, 2011. PMCID: PMC3085989.
  • Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ. Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech. Ageing Dev, Aug;132(8-9):437-42, 2011. PMCID: PMC3179831
  • Fink, DJ, Wechuck, J, Mata, M, Glorioso, JC, Goss, J, Krisky, D, Wolfe, D. Gene Therapy for Pain: Results of a Phase I Clinical Trial. Ann. Neurol. 70(2):207-12, 2011.
  • Neidernhofer, L.J., Glorioso, J.C., Robbins, P.D. Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Re & Ther.1;2(3):28, 2011.
  • Goins,W., Cohen,J., and Glorioso. J. A Brief Overview of Frequently Employed Viral Vectors for Gene Therapy, SFN Short Course in Gene Therapy for Nervous System Diseases. 2011.
  • Dmitrieva N, Yu L, Viapiano M, Cripe TP, Chiocca EA, Glorioso JC, Kaur B. Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. Mar 15;17(6):1362-72, 2011.  PMCID: PMC3140790.
  • Baek H, Uchida H, Jun K, Kim JH, Kuroki M, Cohen JB, Glorioso JC, Kwon H. Bispecific adapter-mediated retargeting of a receptor-restricted HSV-1 vector to CEA-bearing tumor cells. Mol Ther. Mar;19(3):507-14, 2011. PMCID: PMC3048173.
  • Goss JR, Cascio M, Goins WF, Huang S, Krisky DM, Clarke RJ, Johnson JW, Yokoyama H, Yoshimura N, Gold MS, Glorioso JC. HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation Mol Ther. Mar;19(3):500-6, 2011. PMCID: PMC3048176.
  • Bernal PJ, Bauer EM, Cao R, Maniar S, Mosher M, Chen J, Wang QJ, Glorioso JC, Pitt BR, Watkins SC, St Croix CM A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol. Jun;300(6):L874-86, 2011.
  • Glorioso JC. Non-coding RNAs and the advent of new directions in therapeutics. Gene Therapy, Dec, 18(12):1103, 2011.
  • Zhu X, McTiernan CF, Rajagopalan N, Shah H, Fischer D, Toyoda Y, Letts D, Bortinger J, Gibson G, Xiang W, McCurry K, Mathier M, Glorioso JC, London B. Immunosuppression decreases inflammation and increases AAV6-hSERCA2a mediated SERCA2a expression. Hum Gene Ther.  Jul;23(7):722-32, 2012.
  • Jing X, Wang T, Huang S, Glorioso J C, Albers K M. The transcription factor Sox11 promotes nerve regeneration  through activation of the regeneration-associated gene Sprr1a. Exp Neurology 233(1):221-32, 2012.
  • Haseley A, Boone S, Wojton J, Yu L, Yoo J Y, Yu J, Kurozumi K, Glorioso J, Caligiuri, M and Kaur B          Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Res Mar 15;72(6):1353-62, 2012. PMCID: PMC3366191.
  • Yoo, J.Y. Pradarelli, J. Haseley, A. Kaka,  Bratasz, A.  Alvarez-Breckenridge, C. Powell, K. Mazar, A. Teknos, T. Old, M. Glorioso,J.C. Chiocca,E.A. and Kaur,B.. Copper Chelation Enhances Anti-Tumor Efficacy and Systemic Delivery of Oncolytic HSV.  Clinical Cancer Research, Aug 1, 2012 [Epub ahead of print]. PMID: 2275359
  • Salerno KM, Jing X, Diges CM, Cornuet PK, Glorioso JC and Albers KM. Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner. J Neurosci. Res. 90(5):1011-9, 2012. PMCID: PMC3296899
  • Goins, W.F, Krisky, D.M., Wechuck, J.B., Wolfe, D., Huang, S., Glorioso, J.C. Generation of replication-competent and -defective HSV vectors. Cold Spring Harb Protoc. May 1; 5:prot5615, 2012.
  • Oguchi, T., Funahashi, Y., Yokoyama, H., Nishizawa, O., Goins, W.F., Goss, J.R., Glorioso, J.C., Yoshimura, N. Effect of herpes simplex virus vector-mediated interleukin-4 gene therapy on bladder over-activity and nociception. Gene Therapy. March 8, 2012. [Epub ahead of print]. PMID: 22402319
  • Goins, W.F. Cohen, J.B., Glorioso, J.C.Gene Therapy for the Treatment of Chronic Peripheral Nervous System Pain. Neurobiology of Disease. June 2, 2012. [Epub ahead of print].
  • Reinhart, B. Mazzacurati L, Forero A, Hong CS, Eguchi J, Okada H, Fellows W, Niranjan A, Cohen JB, Glorioso JC, Grandi P. Inhibition of Indoleamine-2,3-Dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus.  Adv. Virol. 2012, Article ID 815465, doi:10.1155/2012/815465 PMID:22924042 [PubMed]
  • Wang, P-Y. Currier, M.A., Handsford, L., Kaplan, D., Chiocca, E.A., Uchida, H., Goins, W.F., Cohen, J.B., Glorioso, J.C., van Kuppervelt, T.H., and Cripe, T.P. (2012) Expression of HSV-1 Receptprs in EBV-Associated Lymphoproliferative Disease Determines Susceptibility to Oncolytic HSV.(2012) Dec 20, doi:10.1038/gt.2012.93 [Epub ahead of print] PMID: 23254370 [PubMed-as supplied by publisher]
  • Uchida, H. Marsulli, M. Nakano, K. Goins, W.F., Chan, J. Hong, CS., Mazzacurati, L. Yoo, J.Y. Haseley, A., Nakashima, H. Baek, H., Kwon, H., Kumagai, I., Kuroki, M. Kaur, B. Chocca, A. Grandi, P. Cohen, J.B. and Glorioso, J.C. Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-Retargeted Oncolytic Herpes Simplex Virus. (2012) Mol. Ther. Oct16. Doi: 10.1038/mt 2012.211 [Epub ahead of print] PKID:23070115 [PubMed-as supplied by  publisher]
  • Uchida, H. Chan, J. Shrivastava, I. Reinhart, B. Grandi,P. Glorioso, J.C. and Cohen, J.B. (2012) Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread.(2012) J. Virol. Nov 14 [Epub ahead of print] PID:23152509 [PubMed-as supplied by publisher]
  • Simonato, M., Bennett, J. Boulis, N.M. Castro, M.G. Fink, D. J. Goins, W.F. Gray, S.J. Lowenstein, P.R. Vandenberghe, L.H. Wilson, T.J. Wolfe, J.H. and Glorioso, J.C. (2013) Gene therapy for neurological disorders. Nature Reviews Neurology May Vol 9: 277-291.
  • Funahashi, Y. Oguchi, T. Goins, W.F. Gotoh, M. Tyagi, P. Goss, J.R. Glorioso, J.C. and Yoshimura, N (2013) Herpes simplex virus vector mediated gene therapy of tumor necrosis factor-a blockade for bladder over-ractivity and nociception in rats. J Urol. 2013 Jan; 189(1):366-73. Doi:10.1016/j.juro 2012. 08.192 Epub 2012 Nov 19. PMID:23174234 (PubMed-in process)

Joseph C. Glorioso III.

Professor

 

  • :1(412)648-8538
    Fax: 1(412)624-8997

  • DEPARTMENTDepartment of Neurology
    University of Pittsburgh School of Medicine
  • COUNTRY USA