Publications

Peer-reviewed publications:

  1. Chaudhary, P.M. and Roninson, I.B. (1991). Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66, 85-94. [831 citations]
  2. Chaudhary, P.M., Mechetner, E.B., and Roninson, I .B. (1992). Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 80, 2735- 2739. [332 citations]
  3. Chaudhary, P. M. and Roninson, I.B. (1992). Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncology Research 4, 281-290. [129 citations]
  4. Chaudhary, P.M. and Roninson, I.B. (1993). Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl. Canc. Inst. 85, 632-639.[307 citations]
  5. Han, D.K.*, Chaudhary, P.M.,* Wright, M.E., Friedman, C., Trask, B.J., Riedel R.T., Baskin, D.G., Schwartz, S.M., and Hood, L. (1997). MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proc Natl Acad Sci USA 1 4, 94(21):1133311338. * Co-first authors. [197 citations]
  6. Chaudhary, P.M., Eby, M., Jasmin, A., Bookwalter, A., Murray, J., and Hood, L. (1997). Death Receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway. Immunity 7 (6) 821-830. [475 citations]
  7. Chaudhary, P.M., Ferguson, C., Nguyen, V., Nguyen, O., Massa., H.F., Eby, M., Jasmin, A., Trask, B.J., Hood, L., and Nelson, P.S. (1998). Cloning and characterization of twoToll/Interleukin-1 receptor like genes, TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood 91 (11) 4020-4027. [170 citations]
  8. Choi, K-B., Harlan, J.M., Chaudhary, P.M., Hood, L., and Karsan, A. (1998) Lipopolysaccharide mediates endothelial cell apoptosis by a FADD-dependent pathway. J. Biol. Chem. 273(32) 20185-8. [111 citations]
  9. Yun, T.J., Chaudhary, P.M., Shu, G.L., Frazer, J.K., Ewings, M.K., Schwartz, S., Pasqual, V., Hood, L., and Clark, E.A. (1998). OPG/FDCR-1, a TNFR family member, is expressed in lymphoid cells and is upregulated by ligating CD40. Journal of Immunology. 161(11) 6113- 6121. [156 citations]
  10. Law, C-L*, Chaudhary, P.M.,*, Ewings, M*., Solow, S., Marshall, AQ., Hood, L and Clark, E.A. (1999). GrpL, a Grb2-like adaptor protein, is selectively expressed in lymphoid cells and interacts with SLP-76. J. Exp. Med 19;189(8):1243-53. * Co-first authors. [98 citations]
  11. Chaudhary, P.M., Eby, M., Jasmin, A., and Hood, L. (1999). Activation of the c-Jun N-terminalKinase/Stress activated Protein Kinase pathway by overexpression of Caspase 8 and its homologs. J. Biol. Chem. 274 (27), 19211-19219. [50 citations]
  12. Chaudhary, P.M., Eby, M., Jasmin, A., Gimmell, A and Hood, L. (1999). Modulation of the NF- κB pathway by virally encoded Death Effector Domains-containing proteins. Oncogene.18(42):5738-46. [178 citations]
  13. Eby, M.T., Jasmin, A., Kumar, A., Sharma, K., and Chaudhary, P.M. (2000). TAJ, a novel member of the Tumor Necrosis Factor Receptor family, activates the c-Jun N-terminalKinase pathway and mediates caspase-independent cell death. J. Biol Chem. 275 (20), 15336- 15342. [78 citations]
  14. Chaudhary, P.M., Eby, M., Jasmin, A., Kumar, A., Liu, L., and Hood, L. (2000). Activation of the NF-κB pathway by Caspase 8 and its homologs. Oncogene. 19(39):4451-60. [132 citations]
  15. Kumar A, Eby MT, Sinha S, Jasmin A, and Chaudhary PM. (2001) Ectodermal dysplasia receptor activates the nuclear factor kappa B, c-Jun N-terminal kinase and cell death pathways and binds to ectodysplasin A. J. Biol Chem. 276 (4) 2668-2677. [102 citations]
  16. Kumar, A., Jasmin, A., Eby, M.T., and Chaudhary, P.M. (2001). Cytotoxicity of Tumor Necrosis Factor Related Apoptosis-Inducing Ligand Towards Ewing’s Sarcoma cell lines. Oncogene. 20, 1010-1014. [18 citations]
  17. Taylor, M.A., Chaudhary, P.M., Klem, J., Kumar, V., Schatzle, J.D., and Bennett, M (2001). Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I- deficient stem cells in perforin-deficient mice. J. Immunology. 167(8):4230-7. [13 citations]
  18. Shivapurkar, N., Toyooka, S., Eby, T.M., Huang, C.X., Sathyanarayana, U.G., Cunningham, T., Reddy, J.L., Minna, J.D., Chaudhary, P.M. and Gazdar, A.F. (2002) Differential inactivation of caspase 8 in lung cancer. Cancer biology and therapy 1(1) 65-71.
  19. Liu L, Eby TM, Rathore N, Sinha S and Chaudhary P.M. (2002). The human herpesvirus 8 encoded viral FLICE inhibitory protein physically associates with and persistently activates the IkappaB kinase complex. J. Biol Chem. 277(16):13745-51. [121 citations]
  20. Harada. K., Toyooka, S., Shivapurkar. N., Maitra. A., Jyotsna L. Reddy, Hittu Matta, Charles F. Timmons, Gail E. Tomlinson, Domenico Mastrangelo, Robert J. Hay, Preet M. Chaudhary and Adi F. Gazdar. (2002) Deregulation of Caspase 8 and 10 expression in Pediatric Tumors and cell lines; Cancer Research; 15;62(20):5897-901. [126 citations]
  21. Sun, Q., Matta, H and Chaudhary, P.M. (2003) The human herpesvirus 8 encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF- κB activation. Blood. 101(5):1956-61. [55 citations]
  22. Shivapurkar, N., Toyooka, S., Eby, T.M., Huang, C.X., Sathyanarayana, U.G., Matta, H., Cunningham, T., Reddy, J.L., Minna, J.D., Chaudhary, P.M. and Gazdar, A.F. (2002) Loss of expression of components of Death Inducing Signaling Complex in lung cancer and correlation with Myc expression. Oncogene. 21(55):8510-4. [56 citations]
  23. Sinha S, Zachariah S, Shindo M, Quinones H and Chaudhary P.M. (2002). Role of TRAF-3 and 6 in the activation of the NF-κB and JNK pathways by X-linked Ectodermal Dysplasia Receptor. J. Biol Chem. 277(47): 44953-44961. [39 citations]
  24. Matta, H., Gazdar, A.F., and Chaudhary, P.M. (2002). Role of MRIT/cFLIP) in protection against chemotherapy-induced apoptosis. Cancer biology and therapy. 1(6):652-60. [22 citations]
  25. Kauppila, S., Maaty W, Chen, P., Tomar, R., Eby T.M., Chapo, J., Rathor, N., Zachariah, S., Abrams, J.M. and Chaudhary, P.M. (2003). Eiger and its receptor, Wengen, comprise a TNF- like system in Drosophila. Oncogene. 22(31):4860-7. [83 citations]
  26. Matta, H., Hozayev, B., Tomar, R., Chugh, P. and Chaudhary, P.M. (2003). Use of Lentiviral vectors for delivery of small interfering RNA. Cancer biology and therapy. 2(2):206-10. [35 citations]
  27. Tomar, R., Matta, H and Chaudhary, P.M. (2003) Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene 22(36):5712-5. [100 citations]
  28. Sun, Q., Zachiriah, S and Chaudhary, P.M. (2003) The human herpesvirus 8 encoded viral FLICE inhibitory protein (vFLIP) induces cellular transformation via NF-κB activation. J. Biol. Chem. 278(52):52437-45. [73 citations]
  29. Matta, H., Sun, Q., Moses, G. and Chaudhary, P.M. (2003) Molecular genetic analysis of human herpesvirus 8-encoded viral FLICE inhibitory protein (vFLIP)-induced NF-kappa B activation. J. Biol. Chem. 278(52):52406-11. [31 citations]
  30. Shivapurkar, N., Toyooka, S., Toyooka, K.O., Miyajima, M., Suzuki, M., Shigematsu, H., Takahashi, T., Parikh, G., Reddy, J., Pass, H.I., Chaudhary, P.M., and Gazdar, A.F. (2004) Aberrant Methylation of TRAIL Decoy Receptor genes is Frequent in various tumor types. Int. Journal of Cancer. 109(5):786-92. [100 citations]
  31. Shindo, M and Chaudhary, P.M. (2004) The Ectodermal Dysplasia Receptor (EDAR) represses the Lef-1/β-catenin dependent transcription independent of NF-κB activation.Biochem. Biophys. Res. Comm. 27;315(1):73-8. [7 citations]
  32. Chang, B and Chaudhary, P.M. (2004) High level production and one step purification of biologically active Ectodysplasin A1 and A2 immunoadhesins using the baculovirus/insect cell expression system. Protein Expression and Purification. 37(1):162-9. [3 citations]
  33. Matta, H and Chaudhary, P.M. (2004) Activation of alternative NF-κB pathway by Human herpesvirus 8-encoded viral Fas associated death domain IL-1β converting enzyme inhibitory protein (vFLIP). Proc Natl Acad Sci USA. 101(25): 9399-404. [88 citations]
  34. Rathore, N, Matta, H and Chaudhary, P.M. (2004). An Evolutionary Conserved Pathway ofNF-κB Activation Involving Caspase-mediated Cleavage and N-end rule Pathway-MediatedDegradation of IκBα. J. Biol. Chem. 279(38):39358-65 [27 citations]
  35. Sinha, S and Chaudhary, P.M. (2004). Induction of apoptosis by X-linked Ectodermal Dysplasia Receptor via a Caspase 8-dependent mechanism. J. Biol. Chem. 279(40):41873-81.[14 citations]
  36. Matta, H and Chaudhary, P.M. (2005) The proteasome inhibitor Bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer biology and therapy. 4(1):77-82 [41 citations]
  37. Sun, Q, Matta, H and Chaudhary, P.M. (2005) Kaposi’s Sarcoma Associated Herpesvirus- encoded viral FLICE Inhibitory Protein activates transcription from Human Immunodeficiency Virus-1 Long Terminal Repeat via the classical NF-κB pathway. Retrovirology. 15;2(1):9. [15 citations]
  38. Chugh, P, Matta, H, Schamus, S, Zachariah, S, Kumar, A, Richardson, JA, Smith, AL andChaudhary, P.M. (2005) Constitutive NF-κB activation, normal Fas-induced apoptosis and increased incidence of lymphoma in Human Herpesvirus 8 K13 transgenic mice. Proc Natl Acad Sci USA. 102(36) 12885-12890. [74 citations]
  39. Sun, Q, Lu, G, Matta, H and Chaudhary, P.M. (2006) Induction of IL-8 expression by Human Herpesvirus 8 encoded vFLIP K13 via NF-κB activation. Oncogene. 25(19):2717-26. [58 citations]
  40. Matta, H, Surabhi, RM, Zhao J, Punj V, Sun Q, Schamus S, Mazzacurati L, Chaudhary P.M.(2007) Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13. Oncogene. 26(11):1656-60. [28 citations]
  41. Lacoste, V., Nicot, C., Gessain, A., Valensi, F., Gabarre, J., Matta, H., Chaudhary, P.M., and Mahieux, R. (2007) In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v- GPCR become involved during the lytic cycle. British Journal of Hematology. 138(4):487-501.[3 citation]
  42. Matta, H., Mazzacurati, L., Schamus, S., Sun, and Chaudhary, P.M. (2007) KSHV oncoprotein vFLIP K13 bypasses TRAFs and directly interacts with the IκB kinase complex to selectively activate NF-κB without JNK activation. Journal of Biological Chemistry. 282(34):24858-65. [1 citation]
  43. Chang, B, Punj, V, Shindo, M and Chaudhary, P.M. (2007) Adenoviral-mediated gene transfer of Ectodysplasin-A2 results in induction of apoptosis and cell cycle arrest in osteosarcoma cell lines. Cancer Gene Therapy. 14(11):927-33. [3 citations]
  44. Zhao, J, Punj, V., Yang, Y., Mazzacurati, L., Matta, H., Schamus, Yang, T, and Chaudhary, P.M. (2007) Inhibition of KSHV lytic replication and dysregulation of lytic gene expression program by vFLIP K13: a model for lytic replication-induced clonal selection in viral oncogenesis. PLoS ONE. 2(10):e1067. [10 citations]
  45. Lu, G and Chaudhary, P.M. (2008) Proteasome inhibitor Bortezomib induces cell-cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL. Cancer Biol Ther. 2008 Jan 11;7(4). [28 citations]
  46. Habib, AH, Ondeck, CL, Chaudhary, P.M., Bockstaller, MR and McHenry ME. (2008). Evaluation of iron-cobalt/ferrite core-shell nanoparticles for cancer thermotherapy. J Applied Physics 103, 07A307.
  47. Matta, H., Punj, V, Mazzacurati, L., Schamus, S., Chen, A; Song, R and Chaudhary, P.M.(2008). A Nuclear Role for Kaposi’s Sarcoma Associated Herpesvirus-encoded K13 Protein in NF-κB Activation. Oncogene 27, 5243-53 [ 13 citations]
  48. Punj, V, Matta, H., Schamus, S., Yang, T, Chang, Y and Chaudhary, P.M. (2009) Induction of CCL20 production by Kaposi’s Sarcoma-associated herpesvirus: role of viral FLICE Inhibitory Protein K13-induced NF-κB activation. Blood, 113(22):5660-8. [11 citations]
  49. Shuda, M., Arora, R, Kwun, HJ, Feng, H, Sarid, R, Fernandez-Figueras, MT, Tolstov, Y, Gjoerup, O, Mansukhani, MM, Swerdlow, S., Chaudhary, PM., Kirkwood, JM, Nalesnik, M, Kant, JA, Weiss, LM, Chang, Y and Moore, PS (2009). Human Merkel Cell Polyomavirus infection I. MCV T antigen expression in Merkel Cell carcinoma, lymphoid tissues and lymphoid tumors. Int. J. Cancer ,125(6):1243-9. [141 citations]
  50. Punj, V, Matta, H., Schamus, S., Yang, T and Chaudhary, P.M. (2009). Integrated microarray and multiplex cytokine analyses of Kaposi’s Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13-affected genes in human vascular endothelial cells. BMC Medical Genomics. 6;2:50. [15 citations]
  51. Liu, R., Li, X., Tulpule, A., Zhou, Y., Scehnet, S., Lee, J-S., Zhang, S, Chaudhary, P.M., Jung, J., and Gill, P. (2010) KSHV induced Notch components render endothelial and mural cell characteristics and cell survival. Blood, 115(4):887-95. [21 citations]
  52. Punj, V, Matta, H., Schamus, S., Tamewitz, A., Anyang, B. and Chaudhary, P.M. (2010) Kaposi’s sarcoma associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146a. Oncogene, 29(12):1835-44.[24 citation]
  53. Punj, V, Matta, H., and Chaudhary, P.M. (2010) X-linked Ectodermal Dysplasia Receptor (XEDAR) is Down-regulated in Breast Cancer via Promoter Methylation. Clinical Cancer Res. 16(4):1140-8. [3 citations]
  54. Tolstov, Y.L., Arora, R., Scudiere, S.C., Busam, K., Chaudhary, P.M., Chang, Y and Moore, P.S. (2010) Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood. 115(23): 4973-4. [16 citations]
  55. Liu, R., Gong, M, Li, X., Zhou, Y.,Tulpule, Gao, W., Chaudhary, P.M., Jung, J., and Gill, P.S. (2010) Induction, Regulation and Biological Function of Axl Receptor Tyrosine Kinase in Kaposi’s Sarcoma. Blood, 116(2):297-305. [9 citations]
  56. Ahmad, A., Groshong, JS, Matta, H., Schamus, S., Punj, V, Robinson, LJ. Gill, P.S. andChaudhary, P.M. (2010) Kaposi’s sarcoma associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Cancer Biology & Therapy. 10(10):1033-40. PMCID: PMC3047095. [7 citations]
  57. Matta, H., Gopalakrishnan, R, Punj, V, Yi, H and Suo, Y and Chaudhary, P.M. (2011) A20 is induced by Kaposi's Sarcoma Associated Herpesvirus encoded viral FLICE Inhibitory Protein (vFLIP) K13 and blocks K13-induced NF-κB in a negative feedback manner. Journal of Biological Chemistry. 286(24):21555-64. PMID:21531730. PMCID: PMC3122214. [5 citations]
  58. Yang, Y., Groshong, JS., Matta, H., Gopalakrishnan, R, Yi, H and Chaudhary, P.M. (2011) Constitutive NF-kB activation confers IL6 independence and resistance to dexamethasone and Janus Kinase Inhibitor INCB018424 on murine plasmacytoma cell lines. J Biol Chem. 2011 Aug 12;286(32):27988-97. PMCID: PMC3151044, [5 citations]
  59. Matta, H., Gopalakrishnan, R, Graham, C., Tolani, B., Khanna, A., Yi, H., Suo Y., andChaudhary, PM. (2012) Kaposi's Sarcoma Associated Herpesvirus Encoded viral FLICE Inhibitory Protein K13 Activates NF-κB Pathway Independent of TRAF6, TAK1 and LUBAC. PLoS ONE;7(5):e36601. PMCID: PMC3348130. [5 citations]
  60. Punj, V, Matta, H and Chaudhary, PM (2012) A Computational Profiling of Changes in Gene Expression and Transcription Factors Induced by vFLIP K13 in Primary Effusion Lymphoma.PLoS ONE, 7(5):e37498. PMCID: PMC3356309. [4 citations]
  61. Graham, C., Matta, H., Yang, Y., Yi, H., Suo, Y., Tolani, B., and Chaudhary, PM. (2013) Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation. J Virology, 87(4) 2242-2252.PMCID: PMC3571451.
  62. Tolani, B., Gopalakrishnan, R., Punj, V., Matta, H. and Chaudhary, PM. (2014) Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene,29;33(22):2928-37. PMID:23792448. [2 citations]
  63. Gopalakrishnan, R, Matta, H and Chaudhary, PM (2013). A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated Primary Effusion Lymphoma and blocks vFLIP K13-induced NF-κB. Clinical Cancer Research. 19(18):5016-26.PMCID:PMC3804723. [2 citations]
  64. Tolani, B., Matta, H., Gopalakrishnan, R., Punj, V., and Chaudhary, PM. (2014) NEMO is essential for KSHV-encoded vFLIP K13-induced gene expression and protection against deathreceptor-induced cell death and its N-terminal 251 residues are sufficient for this process. J. Virology. 2014; 88(11):6345-54. PMCID: PMC4093867
  65. Liu, CC, Tseng, Y-T., Li, W., Wu, C-Y., Mayzus, I., Rzhetsky, A., Sun, F., Waterman, M., Chen, J.J.W., Chaudhary, PM, Loscalzo, J., Crandall, E., and Zhou, XJ (2014) DiseaseConnect: a comprehensive web server for mechanism-based disease–diseaseconnections. Nucleic Acid Research, 2014, 42:W137-46.
  66. Zhu, H., Lou, S., Zhou, S., Sun, W., Li, L., Warburton, D., He, Q., Jing, Y., Chaudhary, P.M.and Wu, L. (2014) Decrease in phosphorylation of RARαS77 overcomes retinoid-resistanceto induce transcription response inhibiting AML cell growth. (submitted for publication)
  67. Gopalakrishnan, R., Matta, H., Tolani, B., Triche, T., and Chaudhary, PM. (2014) Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in acereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. (submitted for publication)

Review Articles and Commentaries:

  • Shivapurkar, N., Reddy J, Chaudhary, P.M. and Gazdar, A.F. (2003). Apoptosis and lung cancer: A review. J. of Cellular Biochemistry. 88(5):885-98
  • Chaudhary, P.M. (2003). Death Ligands and Bisindolylmaleimide: A Killer Combination. Cancer biology and therapy
  • Moschos SJ, Chaudhary P.M., Kirkwood JM. (2008). Resolving "kinks" of chemotherapy in melanoma. J Natl Cancer Inst. 2008 Jun 18;100(12):833-5.
  • Lee HR, Lee S, Chaudhary PM, Gill P, Jung JU. (2010) Immune evasion by Kaposi's sarcoma- associated herpesvirus. Future Microbiol. 2010 Sep;5:1349-65.

Book Chapters

  • Chaudhary, P.M. (2004). Death receptors in ectodermal differentiation. In Death receptors in human Cancer. Wafik S. El-Deiry (Ed). Humana Press.
  • Chaudhary, P.M. and Nicholas, J (2008). Molecular Biology of HHV-8 Neoplasia. In Human Cancer Viruses. John Nicholas, Kuan-Teh Jeang, and TC Wu (Ed). Basel, Krager.

Patents Granted

  1. Chaudhary, P.M. and Roninson, I.B. Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression. US patent # 5,464,753. Assigned to the University of Illinois.
  2. Chaudhary, P.M. and Roninson, I.B. Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression. US patent # 5,891,654. Assigned to the University of Illinois.
  3. Chaudhary, P.M., Shtil, A., and Roninson, I.B. Methods for Preventing Multidrug Resistance in Cancer Cells. U.S. patent 5,972,598. Assigned to the inventors.
  4. Chaudhary, P.M., and Roninson, I.B. Methods for Preventing Multidrug Resistance in Cancer Cells. WO 94/06938. Assigned to the University of Illinois.
  5. Chaudhary, P.M. and Hood, L. Proteins capable of regulating NF-kappa B, JNK and apoptosis pathways and methods of using the same. U.S. patent # 06160095. Assigned to the University of Washington/ Stowers Institute for Medical Research.
  6. Chaudhary, P.M. and Hood, L. Proteins capable of regulating NF-kappa B, JNK and apoptosis pathways and methods of using the same. U.S. patent # 06207458. Assigned to the University of Washington/ Stowers Institute for Medical Research.
  7. Chaudhary, P.M. Gene expression in ectodermal dysplasia. US patent # 6994961 B1. Assigned to the University of Texas Southwestern Medical Center at Dallas.

Patents Pending

  1. Chaudhary PM and Gopalakrishnan, R, Compositions and Methods for Treating Primary Effusion Lymphoma. Assigned to the University of Southern California.

Preet M. Chaudhary

Professor and Chief

 

  • :323 865-3916
  • :323 865-0060
  • DEPARTMENTNohl Division of Hematology and Center for the Study of Blood Diseases
    Bloom Chair in Lymphoma Research
    University of Southern California/Norris Cancer Center
  • COUNTRY USA