Publications

1. Hylemon, P.B. and P.V. Phibbs, Jr.:  Independent regulation of hexose catabolizing enzymes and glucose transport activity in Pseudomonas aeruginosa.  Biochem. Biophys. Res. Commun.  48:1041-1048, 1972.
2. Hylemon, P.B., J.S. Wells, J.H. Bowdre, T.O. MacAdoo, and N.R. Krieg: Designation of Spirillum volutans Ehrenberg 1832 as type species of the neotype strain of S. volutans.  Int. J. Syst. Bacteriol.  23:23-27, 1973.
3. Hylemon, P.B., N.R. Krieg, J.S. Wells, and H.W. Jannasch:  The genus Spirillum:  A taxonomic study.  Int. J. Syst. Bacteriol.  23:340-380, 1973.
4. Hylemon, P.B., N.R. Krieg, and P.V. Phibbs, Jr.:  Transport and catabolism of D-fructose by Spirillum itersonii.  J. Bacteriol.  117:144-150, 1974.
5. Hylemon, P.B. and P.V. Phibbs, Jr.:  Evidence against the presence of cyclic-AMP and related enzymes in selected strains of Bacteroides fragilis.  Biochem. Biophys. Res. Commun. 60:88-95, 1974.
6. Hylemon, P.B. and J.A. Sherrod:  Multiple forms of 7-"-dehydroxysteroid dehydrogenase in selected strains of Bacteroides fragilis.  J. Bacteriol.  122:418-424, 1975.
7. Krieg, N.R. and P.B. Hylemon:  The taxonomy of the genus Spirillum.  Ann. Rev. Microbiol.  30:303-325, 1976.
8. Hylemon, P.B. and E.J. Stellwag:  Bile acid transformation rates of selected Gram-positive and Gram-negative intestinal anaerobic bacteria.  Biochem. Biophys. Res. Commun.  69:1088-1094, 1976.
9. Stellwag, E.J. and P.B. Hylemon:  Purification and characterization of bile salt hydrolase from Bacteroides fragilis ssp. fragilis.  Biochim. Biophys. Acta.  452:165-176, 1976.
10. Siegel, L.N., P.B. Hylemon, and P.V. Phibbs, Jr.:  Cyclic 3',5'-adenosine- monophosphate (C-AMP) levels and activities of adenylate cyclase and cyclic-AMP phosphodiesterase in Pseudomonas and Bacteroides.  J. Bacteriol.  129:87-96, 1977.
11. Sherrod, J.A. and P.B. Hylemon:  Purification and characterization of NAD-dependent 7-"-hydroxysteroid dehydrogenase from Bacteroides thetaiotaomicron.  Biochim. Biophys. Acta.  486:351-358, 1977.
12. Hylemon, P.B., J.L. Young, R.L. Roadcap, and P.V. Phibbs, Jr.: Uptake and incorporation of glucose and mannose by whole cells of Bacteroides thetaiotaomicron NCTC 10852.  Appl. Environ. Microbiol.  34:488-494, 1977.
13. Stellwag, E.J. and P.B. Hylemon:  Characterization of 7"-dehydroxylase in Clostridium leptum.  Amer. J. Clin. Nut.  5243-5247, 1978.
14. Harris, J.N. and P.B. Hylemon:  Purification and characterization of NADP-dependent 12-"-hydroxysteroid dehydrogenase from Clostridium leptum.  Biochim. Biophys. Acta.  528:148-157, 1978.
15. Stellwag, E.J. and P.B. Hylemon:  7-"-dehydroxylation of cholic and chenodeoxycholic acid by Clostridium leptum.  J. Lipid Research 20:325-333, 1979.
16. Feighner, S.D., V.D. Bokkenheuser, J. Winter, and P.B. Hylemon: Characterization of a C21 neutral steroid hormone transforming enzyme, 21-dehydroxylase, in crude cell extracts of Eubacterium lentum.  Biochim. Biophys. Acta.  574:154-163, 1979.   
17. Glass, T.L., W.M. Holmes, P.B. Hylemon, and E.J. Stellwag:  Synthesis of guanosine tetra and pentaphosphates by an obligately anaerobic bacterium, Bacteroides thetaiotaomicron in response to molecular oxygen.  J. Bacteriol.  137:956-962, 1979.
18. Glass, T.L. and P.B. Hylemon:  Purification and properties of an NADP+/NAD+ L-glutamate dehydrogenase from Bacteroides thetaiotaomicron.  J. Bacteriol.  141: 1320-1330, 1980.
19. Feighner, S.D. and P.B. Hylemon:  Characterization of a corticosteroid 21-dehydroxylase from the intestinal anaerobic bacterium Eubacterium lentum.  J. Lipid Research.  21:585-593, 1980.
20. Lipsky, R.H. and P.B. Hylemon:  Characterization of an NADH: flavin oxidoreductase induced by cholic acid in a 7-"-dehydroxylating intestinal Eubacterium species.  Biochim. Biophys. Acta.  612:328-336, 1980.
21. White, B.A., R.H. Lipsky, R.J. Fricke, and P.B. Hylemon: Bile acid induction specificity of 7-"-dehydroxylase activity in an intestinal Eubacterium species.  Steroids.  35:103-109, 1980.
22. Hylemon, P.B., A.F. Cacciapuoti, B.A. White, T.R. Whitehead, and R.J. Fricke:  7-"-Dehydroxylation of cholic acid by cell extracts of Eubacterium species V.P.I. 12708.  Amer. J. Clin. Nutr.  33:2507-2510, 1980.
23. Bokkenheuser, V.D., J. Winter, P.B. Hylemon, N.K.N. Ayengar, and E.H. Mosbach:  Dehydroxylation of 16-"-hydroxyprogesterone by fecal flora of man and rat.  J. Lipid Research.  22:95-102, 1981.
24. White, B.A., R.J. Fricke, A.F. Cacciapuoti, T.R. Whitehead, E.H. Mosbach, and P.B. Hylemon:  Cofactor requirements for 7-"-dehydroxylation of cholic and chenodeoxycholic acid in all extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 12708.  J. Lipid Research.  22:891-898, 1981.
25. White, B.A., R.J. Fricke, and P.B. Hylemon:  7-Dehydroxylation of ursodeoxycholic acid by whole cells and cell extracts of Eubacterium sp. V.P.I. 12708. J. Lipid Research, 22:145-153, 1982.
26. Winter, J., S. O'Rourke, V.D. Bokkenheuser, T.L. Glass, and P.B. Hylemon: 16-Dehydroxylation of corticoids by bacteria isolated from fecal flora.  J. of Steroid Biochemistry. 16:231-237, 1982.
27. Sugerman, H.J., G. Austin, H.H. Newsome, P.B. Hylemon, and L.J. Greenfield: Progressive Lethal Canine Peritonitis.  I. Effects on hemodynamics, oxygen consumption and serum catecholamines.  Surgery Gyn. Obst. 154:193-197, 1982.
28. Sugerman, H.J., D. Qureshi, P.B. Hylemon, L.J. Greenfield:  Progressive Lethal Canine Peritonitis.  II. Thrombocytopenia without disseminated intravascular coagulation. Surgery Gyn. Obst. 154:8-12, 1982.
29. Glass, T.L., J. Winter, V.D. Bokkenheuser, and P.B. Hylemon: Biotransformation of l6-"-hydroxyprogesterone by Eubacterium sp-144:  Non-enzymatic reaction of L-cysteine with progesterone.  J. Lipid Research, 23:352-356, 1982.
30. Hylemon, P.B., A.F. Cacciapouti, B.A. White, R.J. Fricke and E.H. Mosbach: Studies on the regulation of 7-dehydroxylase activity by pyrindine nucleotides in cell extracts of Eubacterium sp. V.P.I. 12708.  J. Lipid Research. 24:20-27, l983.
31. Hylemon, P.B. and T.L. Glass.  Biotransformation of bile acids and cholesterol by the intestinal flora of man and animals.  In: The Human Intestinal Microflora in Health and Disease, edited by D.J. Hentges, Academic Press, pp. 192-213, 1983.
32. Sugerman, H.J., J.L. Tatum, J.I. Hirsch, D.E. Sharp, G.D. Qureshi and P.B. Hylemon: Gamma Scintigraphic Localization of Indium-lll Platelets in a Focus of Infection.  Arch. Surg., 118:185-189, 1983.
33. Macdonald, I.A., B.A. White, P.B. Hylemon.  Separation of 7" and 7-hydroxysteroid dehydrogenase activities from Clostridium absonum ATCC 27555 and cellular response of this organism to bile acid inducers, J. Lipid Research. 24:1119-1126, 1983.
34. Hylemon, P.B., R.J. Fricke and E.H. Mosbach.  Antibacterial Properties of  bile acids oxazoline compounds.  Steroids 40:347-357, l982.
35. Whitehead, T.R., Z.R. Vlachevic, Z.F. Beg and P.B. Hylemon. Characterization of active and inactive forms of rat liver HMG-CoA reductase.  Arch. Biochem. Biophys. 230: 483-491, 1984.
36. Hylemon, P.B., W. M. Kubaska, R.J. Fricke, B.I. Cohen and E.H. Mosbach. Metabolism of Bile Acid oxazoline compounds by hepatocyte monolayer cultures and intestinal anaerobic bacteria.  Steroids. 42:105-114, 1983.
37. Glass, T.L. and P.B. Hylemon.  16-"-dehydroxylation of 16-"-hydroxyprogesterone by Eubacterium sp. 144.  Biochem. Biophys. Acta 792:59-68, 1984.
38. P.B. Hylemon.  Metabolism of Bile Acids in Intestinal Microflora.  In: New Comprehensive Biochemistry.  Sterols and Bile Acids.  Vol. 12 edited by Jan Sjovall and H. Danielsson.  Elsevier Biochemical Press, Amsterdam, pp. 331-343 (1985).
39. Paone, D.A.M. and P.B. Hylemon.  HPLC purification and preparation of antibodies to bile acid 7-dehydroxylase polypeptides.  Journal of Lipid Research.  25:1343-1349, 1984.
40. Winter, J., G. N. Morris, S., Locascio, V.D. Bokkenheuser, B.I. Cohen and P.B. Hylemon.  Mode of Action of Steroid Desmolase and reductases synthesized by Clostridium Sp. 19.  Journal of Lipid Research.  25:1124-1131, 1984.
41. Hylemon, P.B., E.C. Gurley, W.M. Kubaska, T.R. Whitehead and Z.R. Vlahcevic.  Suitability of Primary Monolayer Cultures of Adult Rat Hepatocytes for Studies of Cholesterol and Bile Acid Metabolism.  Journal of Biological Chemistry.  260:1015-1019, 1985.
42. Kubaska, W.M., E.C. Gurley, P.B. Hylemon, P. Guzelian and Z.R. Vlahcevic.  Absence of negative Feedback Control of Bile Acid Biosynthesis in Cultured Rat Hepatocytes.  Journal of Biological Chemistry.  260:13459-13463, 1985.
43. Stokes, N. and P.B. Hylemon.  Characterization of a )4-steroid reductase from Clostridium innocuum.  Biochem. Biophys. Acta. 836:255-261, 1985.
44. Hylemon, P.B., D.P. Moody, B.I. Cohen, M. Ure and E.H. Mosbach.  Effect of Bile Acid Analogues on 7-"-Dehydroxylase Activity in Eubacterium V.P.I. 12708.  Steroids.  44: 329-336, 1984.
45. Vlachevic, Z.R., W.M. Kubaska and P.B. Hylemon.  Alterations of Bile Acid Metabolism in Various Disease States.  In: Cholesterol 7-"-hydroxylase, CRC Press 1985.
46. Roberts, I., W.M. Holmes and P.B. Hylemon.  Modified Plasmid Isolation Method for Clostridium perfringens and Clostridium absonum.  App. Environ. Microbiol. 52: 197-199, 1986.
47. Coleman, J.B., W.B. White, Jan Sjovall and P.B. Hylemon.  Biosynthesis of a Novel Bile Acid Nucleotide and mechanism of 7-"-dehydroxylation by an Intestinal Eubacterium sp.  Journal of Biological Chemistry.  262:4701-4704, 1987.
48. Kubaska, W.M., E.C. Gurley, Z. Reno Vlachevic, D. Heuman and P.B. Hylemon. Effect of ursodeoxycholic acid, analogues of ursodeoxycholic acid combination of bile acids on bile acid synthesis in adult rat hepatocyte cultures.  Biochem. Biophys. Acta, 920: 195-204, 1987.
49. Coleman, J.B., W.B. White and P.B. Hylemon.  Molecular cloning of Bile Acid 7-"-dehydroxylase from Eubacterium sp. VPI 12708.  Journal of Bacteriology.  169:1516-1521, 1987.
50. Krafft, A. and P.B. Hylemon.  Characterization of steroid desmolase and 20-"-hydroxysteroid dehydrogenase from Clostridium scindens.  J. Steroid Biochem.  28: 49-54, 1987.
51. Heuman, D.M., C.R. Hernandez, P.B. Hylemon, W.M. Kubaska, C. Hartmann and Z.R. Vlachevic.  Studies of Bile Acid Biofeedback I.  Effect of Tauroursodeoxycholate and Taurocholate on Bile Acid Synthesis in Chronic Bile Fistula Rat.  Hepatology. 8:358-365, 1988.
52. Coleman, J.P. and P.B. Hylemon.  Nucleotide Sequence and Regulation of a Gene Involved in Bile Acid 7-Dehydroxylation from Eubacterium sp. Strain VPI 12708.  Journal of Bacteriology 170:2070-2077, 1988.
53. White, W.B., James P. Coleman and P.B. Hylemon.  Molecular Cloning of a Gene Encoding a 45,000 - Dalton Polypeptide Associated with Bile Acid 7-Dehydroxylation in Eubacterium sp. strain VPI 12708.  Journal of Bacteriology.  170:611-616, 1988.
54. Rashmi, Gopal-Srivastava and P.B. Hylemon.  Purification and characterization of bile salt hydrolase from Clostridium perfringens. Journal of Lipid Research.  29:1079-1085, 1988.
55. Roberts, I.R., W.M. Holmes and P.B. Hylemon.  Construction of a new shuttle plasmid for E. coli and Clostridium perfringens.  Applied and Environmental Microbiology.  54: 268-270, 1988.
56. Heuman, D.M., Z.R. Vlahcevic, M.L. Bailey and P.B. Hylemon.  Regulation of Bile Acid Synthesis II.  Effect of Bile Acid Feeding on Enzymes Regulating Hepatic Cholesterol and Bile Acid Synthesis in the Rat.  Hepatology.  8:892-897, 1988.
57. White, W.B., J.P. Coleman, C. Franklund and P.B. Hylemon.  Evidence for a multigene family involved in bile acid 7-dehydroxylation in Eubacterium sp. VPI 12708.  Journal of Bacteriology.  170:4555-4561, 1988.
58. Roberts, I., P.B. Hylemon and W.M. Holmes.  Isolation of Promoters from two anaerobic bacteria.  Microbios.  54:87-99, 1988.
59. Krafft, A.E. and P.B. Hylemon.  Purification and characterization of 20"-hydroxysteroid dehydrogenase from Clostridium scindens. Journal of Bacteriology.  171:2925-2932, 1989.
60. Heuman, D.M., M.L. Bailey, P.B. Hylemon and Z.R. Vlahcevic.  Regulation of Bile Acid Synthesis III.  Bile Salt Pool Hydrophobicity is Inversely related to activities of cholesterol 7-"-hydroxylase and HMG-CoA reductase in the bile acid fed rat.  J. Lipid Research.  30:1161-1171, 1989.
61. Bjorkhem, I., K. Einarsson, P. Melone and P.B. Hylemon.  On the mechanism of intestinal formation of deoxycholic acid from cholic acid in man:  Evidence for a 3-oxo-)4-steroid intermediate.  J. Lipid Research.  30:1033-1039, 1989.
62. Vlahcevic, Z.R., D.M. Heuman and P.B. Hylemon.  1989.  Physiology and Pathophysiology of Enterohepatic circulation of bile acids.  Chapter 13, Hepatology Textbook, 2nd Ed. Zakim and Boyer, Ed. pp. 341-377, W.B. Saunders Co., Phil., PA.
63. Pandak, W.M., D.M. Heuman, P.B. Hylemon and Z.R. Vlahcevic. Mevinolinic acid, the active metabolite of lovastatin, acutely suppresses bile acid synthesis and cholesterol 7"-hydroxylase in the bile fistula rat.  IN: Trends in Bile Acid Research.  G. Paumgartner, A. Stiehl and W. Gerok, (eds.) Kluwer Academic Press.  pp. 89-91, 1989.
64. Heuman, D.M., Z.R. Vlahcevic, and P.B. Hylemon.  Hydrophilic-Hydrophobic Balance (HHB) determines the potency of bile salts as inhibitors of cholesterol 7"-hydroxylase and HMG-CoA reductase in the rat.  IN:  Trends in Bile Acid Research.  G. Paumgartner, A. Stiehl and W. Gerok, (eds.) Kluwer Academic Press.  pp. 63-65, 1989.
65. Hylemon, P.B., E.J. Studer, W.M. Pandak, D.M. Heuman, Z.R. Vlahcevic and J.Y.L. Chiang.  Improved HPLC assay for measuring cholesterol 7"-hydroxylase activity.  Anal. Biochem.  182:212-216, 1989.
66. Vlahcevic, Z.R., E.C. Gurley, D.M. Heuman and P.B. Hylemon.  Hydrophilic-Hydrophobic Balance of bile salts determines rates of cholesterol efflux from hepatic membranes.  J. Lipid Research, 31:1063-1072, 1990.
67. Hylemon, P.B., P. Bohdan, A.E. Sirica and Z.R. Vlahcevic.  Cholesterol and Bile Acid Metabolism in Primary Cultures of Bile Ductular Epithelial Cells.  Hepatology,  11:982-988, 1990.
68. Pandak, W.M., D.M. Heuman, P.B. Hylemon and Z.R. Vlahcevic.  Regulation of Bile Acid Synthesis:  IV Interrelationship Between Cholesterol and Bile Acid Biosynthesis Pathways.  J. Lipid Research, 31:79-90, 1990.
69. Franklund, C., P. de Prada and P.B. Hylemon.  Purification and characterization of a microbial NADP-dependent bile acid 7"-hydroxysteroid dehydrogenase.  J. Biol. Chem., 265:9842-9849, 1990.
70. Pandak, W.M., Z.R. Vlahcevic, D.M. Heuman, and P.B. Hylemon.  Regulation of Bile Acid Synthesis V.  Inhibition of Conversion of 7-Dehydrocholesterol to cholesterol in Associated with Down-Regulation of Cholesterol 7"-Hydroxylase and Inhibition of Bile Acid Synthesis.  J. Lipid Res., 31:2149-2158, 1990.
71. Gopal-Srivastava, R., D.H. Mallonee, W.B. White and P.B. Hylemon.  Cloning and Sequencing of a Multiple Copy Gene Involved in Bile Acid 7"-Dehydroxylation from Eubacterium sp. VPI 12708.  Journal of Bacteriology, 172:4420-4426, 1990.
72. Mallonee, D.L., B.W. White and P.B. Hylemon.  Cloning and Sequencing of a large Bile Acid Inducible Operon from Eubacterium.  sp. VPI 12708.  J. Bacteriol.  172:7011-7019, 1990.
73. Duckworth, P.F.,  E.C. Gurley, D.M. Heuman, Z.H Beg, Z.R. Vlahcevic and P.B.Hylemon.  Regulation of HMG-CoA Reductase Activity, Protein and m-RNA levels by Bile Salts.  J. Biol. Chem., 266:9413-9418, 1991.
74. Heuman, D.M., W.M. Pandak, P.B. Hylemon and Z.R. Vlahcevic. Conjugates of Ursodeoxycholic acid Protect Human Red Blood Cells Against Membrane-Disrupting Effects of More Hydrophobic Bile Salts.  Gastroenterology, 100:203-211, 1991.
75. Hylemon, P.B., P.D. Melone, C.V. Franklund, E. Lund and I. Björkhem. Mechanism of Intestinal 7"-dehydroxylation of cholic acid:  evidence that allo-deoxycholic acid is an inducible side-product.  J. Lipid Res., 32:89-96, 1991.
76. Hylemon, P.B., L. Raynor, P. Bohdan and Z.R. Vlahcevic.  HPLC Assay for 3ß-hydroxy-)5-C27-steroid Oxidoreductase activity in rat liver microsomes.  Anal. Biochem.  193: 256-259, 1991.
77. Vlahcevic, Z.R., D.M. Heuman and P.B. Hylemon.  Regulation of Bile Acid Biosynthesis.  (Invited Review) Hepatology  13:590-600, 1991.
78. Pandak, W.M., V.C. Li, E.J. Studer, E.C. Gurley, J.Y.L. Chiang, D.M. Heuman, Z.R. Vlahcevic and P.B. Hylemon.  Regulation of cholesterol 7"-Hydroxylase m-RNA and Transcriptional Activity by Bile Salts in the Chronic Bile Fistula Rat.  J. Biol. Chem., 266:3416-3421, 1991.
79. Hylemon, P.B.  Biochemistry and Genetics of intestinal Bile salt metabolism.  In: Bile Acids as Therapeutic Agents.  G. Paumgartner, A. Stiehl and W. Gerok (eds.).  Kluwer Academic Publishers.  pp. 1-11, 1991.
80. Pandak, W.M., Y.C. Li, J.Y.L. Chiang, D.M. Heuman, Z.R. Vlahcevic and P.B. Hylemon.  In: Bile Acids as Therapeutic Agents.  G. Paumgartner, A. Stiehl and W. Gerok (eds.).  Kluwer Academic Publishers.  pp. 45-51, 1991.
81. Vlahcevic, Z.R., D.M. Heuman and P.B. Hylemon.  In: Bile Acids as Therapeutic Agents.  G. Paumgartner, A. Stiehl and W. Gerok (eds.).  Kluwer Academic Publishers.  pp. 177-192, 1991.
82. Baron, S.F., C. Franklund and P.B. Hylemon.  Molecular Cloning and Sequencing of Bile Acid 7"-hydroxysteroid Dehydrogenase from Eubacterium sp VPI 12708.  J. Bacteriol.  173:4558-4569, 1991.
83. Roberts, I., P.B. Hylemon and W.M. Holmes.  Rapid Method for Altering Bacterial Ribosome-Binding Sequences for Overexpression of Proteins in E. coli. Protein Expression and Purification.  2:107-121, 1991.
84. Hylemon, P.B. and D.H. Mallonee.  Molecular Biology of Intestine Bile Salt Metabolism.  (Invited Review), Chimicaoggi, pp. 25-29, April 1991.
85. Mallonee, D.H. and P.B. Hylemon.  Molecular Biology of Bile Acid 7"-Dehydroxylation in an Intestinal Eubacterium species.  In Genetics and Molecular Biology of Anaerobic Bacteria, chapter 47.  Ed. by M. Sebald. pp. 613-623, 1992, Springer-Verlag, N.Y.
86. Lalwani, N.D., P.B. Hylemon and S.C. Strom.  Altered Levels of Phosphoinositide Metabolites and Activation of Guanine-Nucleotide Dependent Phospholipase C in Rat Hepatic Tumors.  J. Cell. Physiol.  147:354-361, 1991.
87. Heuman, D.M., W.M. Pandak, P.B. Hylemon and Z.R. Vlahcevic.  Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes.  Hepatology.  14:920-926, 1991.
88. Mallonee, D.H., J.L. Adams and P.B. Hylemon.  The Bile Acid baiB Gene from Eubacterium sp. Strain VPI 12708 Encodes a Bile Acid-Coenzyme A Ligase.  J. Bacteriol, 174:2065-2071, 1992.
89. Pandak, W.M., D.M. Heuman, P.B. Hylemon and Z.R. Vlahcevic.  Regulation of Cholesterol 7"-Hydroxylase by Taurocholate and Mevalonate.  J. Lipid Res, 33:659-660, 1992.
90. Hylemon, P.B., E.C. Gurley, T. Stravitz, J. Litz and Z.R. Vlahcevic. Hormonal Regulation of Cholesterol 7"-Hydroxylase m-RNA and transcriptional activity in Primary Rat Hepatocytes in Culture.  J. Biol. Chem. 267:16866-16871, 1992.
91. Heuman, D.M., Z.R. Vlahcevic, W.M. Pandak, P.B. Hylemon, Y.S. Kim, J. Lillienau and A.F. Hofmann.  Effect of Cholylsarcosine (Cholyl-N-methylglycine) on hepatic biosynthesis of cholesterol and bile acids and biliary secretion in the rat.  Gastroenterology.  103:1641-1648, 1993.
92. Jones, M.P., W.M. Pandak, D.M. Heuman, J.Y.L. Chiang, P.B. Hylemon and Z.R. Vlahcevic.  Cholesterol 7"-hydroxylase:  Evidence for transcriptional regulation by cholesterol and/or metabolic products of cholesterol in the rat. J. Lipid Res.  34:885-892, 1993.
93. Vlahcevic, Z.R., W.M. Pandak, P.B. Hylemon and D.M. Heuman.  Inhibition of Cholesterol Synthesis Prevents Up-regulation of Cholesterol 7"-Hydroxylase Activity and Bile Acid Synthesis Following Acute Biliary Diversion in the Rat. Hepatology 18:660-668, 1993.
94. Stravitz, R.T., Hylemon, P.B., Heuman, D.M., Hagey, L.R., Schteingart, C.D., Ton-Nu., Hofmann, A.F. and Vlahcevic, Z.R. Transcriptional regulation of cholesterol 7"- hydroxylase m-RNA by conjugated bile acids in primary cultures of rat hepatocytes J. Biol. Chem.  268:13987-13993, 1993.
95. Vlahcevic, Z.R., R.T. Stravitz, E.C. Gurley, W.M. Pandak, D.M. Heuman and P.B. Hylemon.  In vitro and in vivo studies of hormonal regulation of cholesterol 7"- hydroxylase. In:  Bile Acids and The Hepatobiliary System. Eds. Paumgartner, Stiehl and Gerok, Kluwer Academic Publishers, pp. 33-43, 1993.
96. Stravitz, R.T., Z.R. Vlahcevic, A. Stolz and P.B. Hylemon.  In Vitro regulation of hepatic 3"-hydroxysteroid dehydrogenase. In: Bile Acids and The Hepatobiliary System.  Eds. Paumgartner, Stiehl and Gerok, Kluwer Academic Publishers, pp. 73-79, 1993.
97. Purdum, P.P., A. Ulissi, P.B. Hylemon, M. L. Shiffman and E.W. Moore.  Cultured Human Gallbladder Epithelia: Methods and Partial Characterization of a Carcinoma-Derived Model.  Lab. Invest. 68:345-353, 1993.
98. Franklund, C.V., S.F. Baron and P.B. Hylemon.  Characterization of the baiH gene  encoding a bile acid-inducible NADH:flavin oxidoreductase from Eubacterium sp. VPI  12708.  J. Bacteriol.  175:3002-3012, 1993.
99. 99.       Vlahcevic, Z. R., P.B. Hylemon and J.Y. L. Chiang.  Hepatic Cholesterol Metabolism.  In:  The Liver: Biology and Pathology. Ed. I.M. Arias., 1994, pp. 379-389.    Raven Press, N.Y.
100. Stravitz, R.T., P.B. Hylemon and Z.R. Vlahcevic.  The Catabolism of Cholesterol.  Current Opinions in Lipidology. 4:223-229, 1993.
101. Bjorkhem, I., U. Andersson, E. Sudjama-Sugiaman, G. Eggertsen and P.B. Hylemon.  Studies on the link between HMG-CoA reductase and cholesterol 7"-hydroxyla in lymph-fistulated rats.  Evidence for both transcriptional and post transcriptional mechanisms for down-regulation of the two enzymes by bile acids. J. Lipid Res. 34:1497-1503, 1993.
102. Pandak, W.M., Z.R. Vlahcevic, D.M. Heuman, K.S. Redford, J.Y.L. Chiang and P.B. Hylemon.  Effect of different bile salts on the steady-state m-RNA levels and transcriptional activity of cholesterol 7"-hydroxylase.  Hepatology 19: 941-947, 1994.
103. Stravitz, R.T., Z.R. Vlahcevic, W.M. Pandak, A. Stolz and P.B. Hylemon.  Regulation of rat hepatic 3"-hydroxysteroid dehydrogenase in vivo and in primary cultures of rat hepatocytes.  J. Lipid Res.  35: 239-247, 1994.
104. De Prada, P., K. Setchell, and P.B. Hylemon.  Purification and characterization of a novel 17"-hydroxysteroid oxidoreductase from Eubacterium sp. VPI 12708  J. Lipid Res. 35: 922-929, 1994.
105. Hylemon, P.B., R. T. Stravitz, and Z. R. Vlahcevic.  Molecular Genetics and Regulation Bile Acid Biosynthesis.  Progress in Liver Diseases, J.L. Boyer (ed.),  chapter 5, pp 99-120, 1994.
106. Baron, S. F. and P. B. Hylemon.  Expression and characterization of the Bile Acid- Inducible NADH: flavin Oxidoreductase Gene of Eubacterium sp. VPI 12708 in Escherichia coli. Biochim. Biophys. Acta, 1249: 145-154, 1995.
107. Mallonee, D.H., M. Lijewski and P.B. Hylemon.  Expression and characterization in E. coli of a family of bile acid 3"-hydroxysteroid dehydrogenases from Eubacterium sp. Strain VPI 12708.  Current Microbiology 30: 259-263, 1995.
108. Pandak, W. M., D. M. Heuman, P. B. Hylemon, J. Y. L. Chiang and Z. R. Vlahcevic Down-regulation of cholesterol 7"-hydroxylase and HMG-CoA reductase in the bile fistula rat by intraduodentla but not by intravenous infusion of taurocholate.   Gastroenterology, 108: 533-544, 1995.
109. Stravitz, R.T., Z. R. Vlahcevic, E. C. Gurley and P.B. Hylemon. Bile acids down-regulate cholesterol 7"-hydroxylase transcriptional activity by activation of protein kinase C in primary rat hepatocyte cultures.  J. Lipid Res., 36: 1359-1369, 1995.
110. Doerner, K., E.C. Gurley, Z.R. Vlahcevic and P.B. Hylemon.  Regulation of cholesterol 7"- hydroxylase and HMG-CoA reductase by squalostatin in primary cultures of adult rat hepatocytes.   J. Lipid Research, 36: 1168-1177, 1995.
111. Stravitz, R.T., Z.R. Vlahcevic, E.C. Gurley and P.B. Hylemon.  Regulation of cholesterol 7"-hydroxylase in mRNA and transcriptional activity by protein phosphorylation in primary cultures of rat hepatocytes.  In: Bile Acids in Gastroenterology: Basic and Clinical Advances.  Eds. A.F. Hofmann, G. Paumgartner and a. Stiehl.  Kluwer Academic Publ., pp. 119-128, 1995.
112. Ghosh, S., D.H. Mallonee, P.B. Hylemon, W.M. Grogan.  Molecular Cloning and Expression of rat neutral cholesterol ester-hydrolase.  Biochem. Biophys. Acta., 1259: 305-312, 1995.
113. Baron, S.F. and P.B. Hylemon.  Biotransformation of bile acids, cholesterol and steroid hormones by intestinal bacteria.  In: Ecology and physiology of gastrointestinal microbes, Chapter 14, Eds. R.I. Mackie and B.A. White. Chappman and Hall, pp. 470-510.  1996.
114. Vlahcevic, Z.R., D. M. Heuman, and P.B. Hylemon.  Physiology and Pathology of Enterohepatic Circulation of Bile Acids. In:  Hepatology: a Textbook of Liver Disease, Eds. Zakim, D. and Boyer, T. , Third edition, vol. 1, WB Sanders, Philadelphia, pp 376-417, 1996.
115. Stravitz, R.T., T.R. Russell, Z.R. Vlahcevic, M.L. Heizer, N.G. Auadhani  and P.B. Hylemon.  Regulation of sterol 27-hydroxylase and the “Acidic” Pathway of Bile Acid Biosynthesis in primary cultures of  rat hepatocytes. J. Steroid Biochemistry and Molecular Biology, 57: 337-347, 1996.
116. Vlahcevic, Z.R., S.K. Jainath, D.M. Heuman, R.T. Stravitz, P.B. Hylemon and W.M. Pandak.  Transcriptional Regulations of Hepatic sterol 27-Hydroxylase by Bile acids.  Amer. J. Physiology, 33: G646-652, 1996.
117. Stravitz, R.T., Y. P. Rao, E.C. Gurley, Z.R. Vlahcevic and P.B. Hylemon.  Differential activation of protein kinase C isoforms by bile acids in primary rat hepatocyte cultures.  Amer. J. Physiology, 34:6293-6303, 1996.
118. Berr, F., G.A. Kullak-Ublick, G. Meiss, W. Miivzing, and P.B. Hylemon.  The intestinal microflora regulates deoxycholate  acid levels in cholesterol gallstone disease.  Gastroenterology.  111: 1611-1620, 1996.
119. Adams, J.L., D.H. Mallonee, I. Bjorkhem and P.B. Hylemon.  The Bile Acid baiE Gene from Eubacterium sp. Strain VPI 12708 encodes a bile acid 7"-dehydratase.  J. Lipid Res., 37:1258-1267, 1996.
120. Mallonee, D.H. and P.B. Hylemon.  Expression and Characterization of a Bile Acid Transporter from Eubacterium sp VPI 12708.  J. Bacteriology. 178:7053-7058 1996. 
121. Vlahcevic ZR, Stravitz RT, Heuman DM, Hylemon PB and Pandak WM.  Regulation of sterol 27-hydroxylase and its role in the regulation of “acidic” pathway of bile acid biosynthesis.  Falk Symp. #93.  Bile Acids in Hepatobiliary Disease.  Ed. G. Paumgartner, A. Stiehl and W. Gerok, pp 48-62, 1997.
122. Vlahcevic ZR, Stravitz RT, Heuman DM, Hylemon PB and Pandak WM. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.   Gastroenterology 113:1949-1957, 1997.
123. Rao YP, Stravitz RT, Vlahcevic ZR, Gurley EC, Sando JJ and Hylemon PB.  Activation of protein kinase C" and * by bile acids: correlation with bile acid structure and diacylglycerol formation.  J. Lipid Research 38:2446-22454, 1997.
124. Pandak WM, Vlahcevic ZR, Redford K, Stravitz RT, Heuman DM, Chiang JYL and Hylemon PB.  Hormonal regulation of cholesterol 7"-hydroxylase specific activity, mRNA levels and transcriptional activity in vivo in the rat.  J. Lipid Res. 38:2483-2491, 1997.
125. Doerner KC, Takamine F, LaVoie CP, Mallonee DH and Hylemon PB.  Assessment of fecal bacteria with bile acid 7"-dehydroxylating activity for the presence of bai-like genes.  Applied and Environmental Microbiology 63:1185-1188, 1997.
126. Mallonee DH and Hylemon PB.  Cloning and characterization of a regulon involved in bile acid transport and 7-dehydroxylation in an intestinal Eubacterium species.  Falk Symposium #93.  Bile Acids in Hepatobiliary Disease.  Ed. G. Paumgartner, A. Stiehl and W. Gerok, pp 191-204, 1997.
127. Jarvis WD, Auer KL, Spector M, Kunos G, Grant S, Hylemon PB, Mikkelsen R and Dent P.  Positive and negative regulation of JNK1 by protein kinase C and p42MAP kinase in adult rat hepatocytes.  FEBS Letters 412:9-14, 1997.
128. Ghosh, S., Natarajan, R., Pandak, W.M., Hylemon, P.B. and Grogan, W.M. Regulation of hepatic neutral cholesteryl ester hydrolase by hormones and changes in cholesterol flux. Am.  J. Physiol.  274(Gastrointest.  Liver Physiol.  37):G662-G668, 1998.
129. Takamine, F, Teisuke, I., Doerner, K.C., Mallonee, D.H., and Hylemon, P.B. Molecular Biology of bile acid metabolism by intestinal bacteria-on bile acid 7"-dehydroxylation-(In Japanese).  J. Intestinal Microbiology Vol.  11 (2):97-104, 1998.
130. Coleman JP, Kirby LC, Setchell KDR, Hylemon PB, Pandak WM, Heuman DM and Vlahcevic ZR.  Physiological effects and metabolic fate of reverse amide analogs of conjugated ursodeoxycholate.  J. Steroid Biochemistry & Molecular Biology.  64:91-101, 1998.
131. Rao YP, Vlahcevic ZR, Stravitz RT, Mallonee DH, Mullick J, Avadhani NG and Hylemon PB.  Down-regulation of the rat hepatic sterol 27-hydroxylase gene by bile acids: Possible role of hepatic nuclear factor 1".  J. Steroid Biochemistry & Molecular Biology 70:1-14, 1999.
132. Ye H-Q, Mallonee DH, Wells JE, Björkhem I and Hylemon PB.  The bile acid-inducible baiF gene from Eubacterium sp. Strain VPI 12708 encodes a bile acid-coenzyme A hydrolase.  J. Lipid Res. 40:17–23, 1999.
133. Mallonee DH and Hylemon PB.  Use of short A/T-rich cassette for enhanced expression of cloned genes in Escherichia coli. Molecular Biotechnology 11:27-35, 1999.
134. Hylemon, P.B. and Harder, J. Biotransformation of monoterpenes, sterols and other isoprenoids in anaerobic ecosystems.  FEMS Microbiol. Revs. 22:475-488, 1999.
135. Vlahcevic, Z.R., Hylemon, PB, Stravitz, RT, Heuman, DM and Pandak, WM. The  regulation of different bile acid biosynthetic pathways and their quantitative contribution to  bile acid synthesis: IN: Paumgartner, G., Stiehl, A, and Gerok, W. (eds) Falk Symposium Proceedings 108: Bile Acids and Cholestasis. Kluwer Academic Publishers, Lancaster, England pp31-37, 1999.
136. Stravitz, RT., Vlahcevic, ZR and Hylemon, PB.  Signal transduction pathways regulating Cholesterol 7"-hydroxylase transcription by bile acids. IN: Paumgartner G, Stiehl, A and Gerok, W. (eds), Falk Symposium Proceedings 108: Bile Acids and Cholestasis.  Kluwer Academic Publishers, Lancaster, England, pp. 52-58, 1999.
137. Pandak, WM, Bjorkhem, I, Eggertsen, G., Hylemon, PB, and Vlahcevic, ZR. Regulation of Sterol 12" hydroxylase and cholic acid synthesis.  IN: Paumgartner, G., Stiehl, A and Gerok W. (eds), Falk Symposium Proceedings 108: Bile Acids and Cholestasis. Kluwer Academic Publishers, Lancaster, England 59-64, 1999.
138. Wells, J. E., F. Berr, L. A. Thomas, R. H. Dowling, and P.B. Hylemon. Isolation and characterization of cholic acid 7"-dehydroxylating fecal bacteria from cholesterol gallstone patients.  J. Hepatology 32:4-10, 2000.
139. Wells, J. E. and P. B. Hylemon. Identification and characterization of a bile acid inducible operon in Clostridium TO-931, a highly active 7"-dehydroxylating bacterium from human feces.Appl. Enviorn. Microbiol. 66(3):1107-ll13, 2000.
140. Vlahcevic, Z.R, Eggestersen, G., Bjorkehm, I.  Hylemon, PB, and Pandak, WM.  Regulation sterol 12"-hydroxylase and cholic acid biosynthesis.  Gasteroenterology 118:1-10, 2000.
141. Gupta, S., Stravitz, RT, Pandak, WM, Muller, M, Vlahcevic, ZR, and Hylemon, PB. Regulation of MDR2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes.  Hepatology 32:341-347, 2000
142. Park, J.S., L. Qiao, D., Filfor, M.Y. Yang, P. B. Hylemon, C. Benz, G. Darlington, G. Firestone, P. B. Fisher and P. Dent. A role for both Ets and C/EBP transcription and mRNA Stabilization in the MAPK-dependent increase in p21 (Cop-/Waf1/mda6) protein levels in Primary hepatocytes. Mol. Biol. Cell 11(9)2915-2932, 2000.
143. Hylemon, P.B., W.M. Pandak, and Z.R. Vlahcevic. Regulation of hepatic cholesterol homeostasis. IN: The Liver: Biology & Pathobiology, 4th ed. .  I. Arias, et al (eds.), Lippincott, Williams &Wilkins, pp. 231-247, 2001.
144. Hylemon, P.B., S. Gupta, E. Studer, P. Dent, and Z. R. Vlahcevic. Bile acid activated cell  signaling cascades and the regulation of cholesterol 7"-hydroxylase in primary rat hepatocytes Falk Symposium #120. Biology of Bile Acids in Health and Disease. Ed. G.P. van Berg Henegovan, D. Keppler, U. Leuschner, G. Paumgartner. pp. 59-70, 2001.
145. Gupta, S., R.T. Stravitz, P. Dent and P.B. Hylemon.  Down-regulation of cholesterol 7alpha-hydroxylase (CYP7a1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase (JNK) pathway.  J. Biol. Chem. 276:15816-15822, 2001.
146. Hall, E.H., P.B. Hylemon, Z.R. Vlahcevic, D. Mallonee, K. Valerie, N.G. Avadhani and W.M. Pandak.  Overexpression of CYP27 in hepatic and extrahepatic cells: Its role in the regulation of cholesterol homeostasis. Am. J. Physiology 281:G293-G301, 2001.
147. Pandak, W.M., P. Bohdan, C. Franklund, D.H. Mallonee, G. Eggertsen, I. Bjorkhem, G. Gil,  Z.R. Vlahcevic and P.B. Hylemon.  Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.  Gastro. 120:1801-1809, 2001.       
148. Qiao L., E. Studer, K. Leach, R. McKinstry, S. Gupta, R. Decker, R. Kukreja, K. Valerie, P. Nagarkatti, W. El Deiry, J. Molkentin, R. Schmidt-Ullrich, P.B. Fisher,  S. Grant, P.B. Hylemon and P. Dent. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes:  Inhibition of EGFR/mitogen activated protein kinase signaling module enhances DCA-induced apoptosis.  Molecular Biology of the Cell 12:2629-2645, 2001.
149. Pandak, W.M., C. Schwarz, P.B. Hylemon, D. Mallonee, K. Valerie, D.M. Heuman, R.A. Fisher, K. Redford and Z.R. Vlahcevic.  Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.  Am. J. of Physiology 281:G878-G889, 2001.                                                    
150. Thomas, L.A., M.J. Veysey, G. French, P.B. Hylemon, G.M. Murphy, and R.H. Dowling.  Bile acid metabolism by fresh human colonic contents: a comparison of caecal and faecal samples.  Gut 49:835-42, 2001.
151. Qiao, L., K. Leach, R. McKinstry, D. Gilfor, A. Yacoub, J.S. Park, S. Grant, P.B. Hylemon, P.B. Fisher and P. Dent.  Hepatitis B virus X protein increases expression of p21(Cip-1/WAFI/MDA) and p27 (Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.  Hepatology 34:906-17, 2001.
152. Rao, Y.P., E.J. Studer, R.T. Stravitz, S. Gupta, L. Qiao, P. Dent, and P.B. Hylemon.  Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor in primary rat hepatocytes.  Hepatology 35:307-14, 2002.
153. Qiao, L., A. Yacoub, E. Studer, S. Gupta, X.Y. Pei, S. Grant, P.B. Hylemon and P. Dent.  Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.  Hepatology 35:779-89, 2002
154. Gerbod-Giannone, M.C., A. Del Castillo-Olivares, S.  Janciauskiene, G. Gil, and P.B. Hylemon.  Suppression of cholesterol 7a-hydroxylase transcription and bile acid synthesis by an a1-antitrypsin peptide via interaction with a1-fetoprotein transcription factor.  J. Biol. Chem. 277:42973-80, 2002.
155. Gupta, S., W.M. Pandak and P.B. Hylemon.  LXR alpha is the dominant regulator of CYP7A1 transcription.  Biochem. Biophys. Res. Commun 293:338-43, 2002.
156. Qiao, L., R. McKinstry, S. Gupta, D. Gilfor, J.J. Windle, P.B. Hylemon, S. Grant, P.B. Fisher and P. Dent.  Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.  Hepatology 36:39-48, 2002.
157. Pandak, W.M., P.B. Hylemon, D. Marques, S. Ren, G. Gil, K. Redford, D. Mallonee and Z.R. Vlahcevic. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.  Hepatology, 35:1400-1408, 2002.
158. Pandak, W.M., S. Ren, D. Marques, G. Gil, K. Redford, E. Hall, D. Heuman and P.B. Hylemon Transport of cholesterol into mitochondria is rate limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. J. Biol. Chem. 277(50):48158-48164, 2002.
159. Qiao, L., R. McKinstry, S. Gupta, D. Gilfor, J.J. Windle, P.B. Hylemon, S. Grant, P.B. Fisher, and P. Dent. Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.  Hepatology 36:39-48, 2002.
160. Ren, S., D. Marques, G. Gil, K. Redford, Z.R. Vlahcevic, Pandak W.M. and P.B. Hylemon.   Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in rat. Metabolism, 52(5), 636-642, 2003.
161. Wells, J.E., K.B. Williams, T.R. Whitehead, D.M. Heuman, and P.B. Hylemon.  Development and application of a polymerase chain reaction assay for the detection and enumeration of bile acid 7a-dehydroxylating bacteria in human feces.  Clin. Chim. Acta. 331(1-2):127-134, 2003.
162. Leach, J.K., L. Qiao, Y. Fang, S.L. Han, D. Gilfor, P.B. Fisher, S. Grant, P.B. Hylemon,  D. Peterson, and P. Dent. Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate iinitiation site X proteins, AUG2 and AUG3.  J. Gastroenterol. Hepatol. 18:376-85, 2003.
163. Lombard, C., R.J. McKallip, P.B. Hylemon, P.S.  Nagarkatti and M. Nagarkatti.  Fas ligand-dependent and -independent mechanism of toxicity induced by cell lymphomas in lymphoid organs and in the liver.  Clin. Immunology 109:144-153, 2003.
164. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P:  Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.  Mol Cell Biol. 23:3052-3066, 2003.
165. Gupta S, Natarajan R, Payne SG, Studer EJ, Spiegel S, Dent P, Hylemon PB:  Deoxycholic acid activates the c-jun-N-terminal kinase (JNK) pathway via FAS receptor activation in primary hepatocytes: Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.  J Biol Chem, 279:5821-5828, 2004.
166. Williams K, Rao YP, Natarajan R, Pandak WM, Hylemon PB:  Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7alpha-hydroxylase mRNA levels.  Biochem Pharmacol, 67:255-267, 2004.
167. Han SI, Studer E, Gupta S, Fang Y, Qiao L, Li W, Grant S, Hylemon PB, Dent P:  Bile acids enhance the activity of the insulin receptor and glycogen synthase primary rodent hepatocytes.  Hepatology, 39:456-462, 2004.
168. Ren S, Hylemon P, Marques D, Hall E, Redford K, Gil G, Pandak WM:  Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP2) on bile acid synthesis.  J Lipid Res, 45:2123-2131, 2004.
169. Fang Y, Han SI, Mitchell C, Gupta S, Studer E, Grant S, Hylemon PB, Dent P:  Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes.  Hepatology, 40:961-971, 2004.
170. Ren S, Hylemon PB, Marques D, Gurley E, Bohdan P, Hall E, Redford K, Gil G, Pandak WM:  Overexpression of cholesterol transporter StAR increases in vivo rates of bile acid synthesis in the rat and mouse.  Hepatology, 40:910-917, 2004.
171. Hylemon PB, Gupta S, Natarajan R, Dent P: Regulation of bile acid biosynthesis by cell signaling pathways.  Falk Symposium # 141, Bile Acid Biology and its Therapeutic Implications.  Eds. G Paumgartner, D Keppler, U Leuschner, A Stiehl, pp. 64-72, 2004.
172. McGarr SE, Ridlon JM, Hylemon PB:  Diet, anaerobic bacterial metabolism, and colon cancer, a review of the literature.  J Clin Gastroenterol, 39:98-109, 2005.
173. Ridlon JM, McGarr SE, Hylemon PB.  Development of methods for detection and quantification of 7alpha-dehydroxylating clostridia, Desulfovibrio vulgaris, Methanobrevibacter smithii, and Lactobacillus plantarum in human feces.  Clin Chim Acta 357(1):55-64, 2005.
174. Hall EA, Ren S, Hylemon PB, Rodriguez-Agudo D, Redford K, Marques D, Kang D-J, Gil G, Pandak WM.  Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells.  Biochim Biophys Acta (Molecular and Cell Biology of Lipids) 1733(2-3):111-119, 2005.
175. Zhou H, Pandak WM, Lyall V, Natarajan R, Hylemon PB.  HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease.  Mole. Pharmacol.  68(3):690-700, 2005.
176. Rodriguez-Agudo D, Ren S, Hylemon PB, Redford K, Natarajan R, Del Castillo A, Gil G, Hylemon PB.  Human StarD5, a cytosolic StAR-related lipid binding protein.  J Lipid Res 46(8):1615-1623, 2005.
177. Langston TB, Hylemon PB, Grogan WM.  Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27 and CYP7A1.  Lipids 40(1):31-38, 2005.
178. Dent P, Han SI, Fang Y, Gupta S, Studer E, Grandis J, Grant S, Krystal GW, Hylemon PB.  Inhibition of insulin/IGF-1 receptor signaling by NVP-ADW742 promotes cell death and enhances bile acid toxicity in primary hepatocytes.  Biochem. Pharmacology 70(11):1685-96, 2005.
179. Dent P, Fang Y, Gupta S, Studer E, Mitchell C, Spiegel S, Hylemon PB.  Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.  Hepatology 42(6):1291-9, 2005.
180. Ridlon JM, Kang DJ, Hylemon PB.  Bile salt biotransformation by human intestinal bacteria.  J. Lipid Res. 47(2):241-59, 2006.
181. Hall EA, Ren S, Hylemon PB, Redford K, del Castillo A, Gil G, Pandak WM.  Mitochondrial cholesterol transport: a possible target in the management of hyperlipidemia.  Lipids 40(12):1237-44, 2005.
182. Ren S, Hylemon PB, Zhang ZP, Rodriguez-Agudo D, Marques D, Li X, Zhou H, Gil G, Pandak WM.  Identification of a novel sulfonated oxysterol, 5-cholesten-3beta,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria.  J Lipid Res. 47(5):1081-90,2006.
183. Rodriguez-Agudo D, Ren S, Hylemon PB, Montanez R, Redford K, Natarajan R, Medina MA, Gil G, Pandak WM.  Localization of StarD5 cholesterol binding protein.  J Lipid Res. 47(6):1168-75, 2006.
184. Li X, Hylemon PB, Pandak WM, Ren S.  Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria.  J Lipid Res. 47(7):1507-12, 2006.
185. Ridlon JM, Hylemon PB.  A potential role for resistant starch fermentation in modulating colonic bacterial metabolism and colon cancer risk.  Cancer Biol Ther 5(3):273-4, 2006.
186. Zhou H, Gurley EC, Jarujaron S, Ding H, Fang Y, Xu Z, Pandak WM, Hylemon PB.  HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes.  Am J Physiol Gastrointest Liver Physiol. 29(116):G1071-G1080, 2006.
187. Zhou H, Pandak WM, Hylemon PB.  Cellular mechanism of lipodystrophy induction by HIV protease inhibitors.  Future Lipidology 1(2):163-172, 2006.
188. Fang Y, Studer E, Mitchell C, Grant S, Pandak WM, Hylemon PB.  Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via G"i signaling.  Molecular Pharmacology 71:1122-1128, 2007.
189. Mitchell C, Park MA, Zhang G, Han SI, Harada H, Franklin RA, Yacoub A, Li PL, Hylemon PB, Grant S, Dent P.  17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.  Molecular Cancer Therapy 6:618-632, 2007.
190. Ren S, Li X, Rodriguez-Agudo D, Gil G, Hylemon P, Pandak WM.  Sulfated oxysterol, 25HC3S, is a potentt regulator of lipid metabolism in human hepatocytes.  Biochem. Biophys. Res. Commun. 360:802-808, 2007.
191. Hylemon PB, Fang Y, Studer E, Pandak WM, Dent P.  Activation of a G-protein coupled receptor by conjugated bile acids in primary hepatocytes and liver:  effects on glucose metabolism.  In:  Falk Symposium 155 – Bile Acids:  Biological Actions and Clinical Relevance.  Editors D, Keppler, et al.  Springer Publishing, Dordrecht, The Netherlands, pp 11-19, 2007.
192. Ren S, Hylemon PB, Li X, Rodriguez-Agudo D, Zhou H, Erickson S, Gil G, Pandak WM.  Discovery of a novel oxysterol, 5-cholesten-3b, 25-diol 3-sulphate, in nuclei and mitochondria following over-expression of the gene encoding StarD1.  In:  Falk Symposium 155 – Bile Acids:  Biological Actions and Clinical Relevance.  Editors D, Keppler, et al.  Springer Publishing, Dordrecht, The Netherlands, pp 20-36, 2007.
193. Xu Z, Tavares-Sanchez OL, Li Q, Fernando J, Rodriguez CM, Studer EJ, Pandak WM, Hylemon PB, Gil G.  Activation of Bile Acid Biosynthesis by the p38 Mitogen-Activated Protein Kinase (MAPK).  J. of Biol. Chemistry.  282(34):24607-24614, 2007.
194. Ren S., Li X, Rodriguez-Agudo D, Gil G, Hylemon P, Pandak W. M. Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes.  Biochem Biophys Res. Commun. 360(4): 802-808, 2007.
195. Li X, Pandak W M, Erickson SK, Ma Y, Yin L, Hylemon P, Ren S. Biosynthesis of the regulatory oxysterol, 5-cholesten-3-beta,25-diol 3-sulfate, in hepatocytes.  J. Lipid Res. 48(12) 2587-2596, 2007.
196. Kang D J, Ridlon JM, Moore DR, Barnes S, Hylemon PB.  Clostridium scindens baiCD and baiH genes encode stereospecific 7 alpha/7 beta-hydroxy-3-oxo-delta 4-cholenoic acid oxidoreductases. Biochim Biophys Acta 1781(1-2)16-25, 2008.
197. Dent P, Hylemon PB, Grant S, Fisher PB. Approches for monitoring signal transduction changes inin normal and cancer cells. Methods. Mol Biol 383:259-276, 2007.
198. Liang G, Li X, Chen L, Yang S, Wu X, Studer E, Gurley E, Hylemon PB, Ye F, Li Y, Zhou H. Synthesis and anti-inflammatory activities of mon-carbonyl analogues of curcumin. Bioorg. Med Chem Lett. 18(4) 1525-1529, 2008. 
199. Rodriguez-Agudo D, Ren S, Wong E, Marques D, Redford K, Gil G, Hylemon P, Pandak WM.Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholestereryl- Ester formation.  J. Lipid Res. 49(7) 1409-1419, 2008.
200. Wu X, Zhang L, Gurley E, Studer E, ShangJ, Wang T, Wang C, Yan M., Jiang Z, Hylemon PB,Sanyal AJ, Pandak WM Jr., Zhou H. Prevention of free fatty acid-induced hepatic lipotoxicity by 18-beta-glycrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology 47(6) 1905-1915, 2008.
201. Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P. Multiple cyclin kinase inhibitors promote bile acid-Induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. J. Biol Chem 283(36)24343-24358, 2008.
202.  Park MA, Zhang G, Norris J, Hylemon PB, Fisher PB, Grant S, Dent P. Regulation of autophagy by Ceramide-CD95-PERK signaling. Autophayg 4(7) 929-931, 2008.   
203. Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, Graf M, Rahmani M,      Ryan K, Liu X, Spiegel S, Norris J, Fisher PB, Grant S, Dent P. Vorinostat and sorafenib   increase ER stress, Autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol.  Ther. 10:1648-1662, 2008
204. Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, Ren S.25-   hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. Am. J. Physiol Endocrinol Metabol. 295(6)E1369-E1679, 2008.
205. Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, Bellamine A.  The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: Cellular Mechanisms and clinical implications. Toxicol Pathol 37(1) 65-77, 2009. 
206. Hylemon PB, Zhou H, Studer E, Pandak WM, and Dent P. Conjugated bile acids regulate hepatic gluconeogenic genes via Gαi protein-coupled receptor(s) and the insulin signaling pathway. In:Bile Acid Biology and Therapeutic Actions.  Editors: D. Keppler et al. Springer Publishing, Dordrecht, The Netherlands, pp. 57-66, 2009.
207. Hylemon, P.B. and Ridlon J. M.  Influence of diet on microbial production and utilization of H2, CH4, H2S In the colon:  Physiological and pathophysiological consequences.  Old Hebron University  Seminar Series, 2009.  
208. Hylemon P.B., Zhou H, Pandak W M, Ren S, Gil G and Dent P. Bile acids as regulatory molecules. J. Lipid Res. 50(8):1509-1520, 2009
209. Chen, L, Jarujaron S, Wu S, Sun L, Zha W, Liang G, Wang X, Gurley EC, Studer EJ, HylemonP. B Pandak WM, Dent P, Zhou H. Biochem Pharmacology. 78(1):70-77, 2009
210. Ridlon JM, Kang DJ, Hylemon PB Isolation and characterization of a bile acid inducible 7-alpha-deydroxylating operon in Clostridium hylemonae.  Anaerobe. 16(2):137-146, 2009.
211. Wu X, Sun L, Zha W, Studer E, Gurley E, Chen L, Wang X, Hylemon PB, Pandak Wm, Sanyal AJ, Zhang L, Wang JY, Zhou H.  HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells.  Gastroenterology 138(1):197-209, 2009.
212. Zha W, Liang G, Xiao J, Studer EJ, Hylemon PB, Pandak WM, Wang G, Li X, Zhou H. Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling in macrophages. PLoS One 5(2):e9069, 2010.
213. Cao R, Cronk ZX, Zha W, Sun L, Wang X, Fang Y, Studer E, Zhou H, Pandak WM, Dent P, Gile G, Hylemon PB. Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein coupled receptor pathway.  J. Lipid Res. 51(8):2234-2244, 2010.
214. Cao R, Hu Y, Wang Y, Gurley EC, Studer EJ, Wang X, Hylemon PB, Pandak WM, Sanyal AJ, Zhang L, Zhou H.  Prevention of HIV protease inhibitor-induced dysregulation of hepatic lipid metabolism by raltegravir via endoplasmic stress signaling pathways. J Pharmacol Exp Ther. 334(2):530-539, 2010.
215. Xu L, Bai Q, Rodriguez-Aguado D, Hylemon PB, Heuman DM, Pandak WM, Ren S. Regualtion of lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol sulfate. Lipids 45(9):821-832, 2010.
216. Bai Q, Xu L, Kakiyama G, Runge-Morris MA, Hylemon PB, Yin L, Pandak WM, Ren S. Sulfation of 25-hydroxycholesterol by SULT2B1b decrease cellular lipids via the LXR/SREBP-1c signaling pathways.  Atherosclerosis. 214(2):350-356, 2011.
217. Rodriguez-Agudo D, Calderon-Dominguez M, Ren S, Marques D, Redford K, Medina-Torres MA, Hylemon P, Gil G, Pandak WM. Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Biochim Biophys Acta 1811(10):597-606, 2011.
218. Boini KM, Xia M, Li C, Zhang C, Payne LP, Abais JM, Poklis JL, Hylemon PB, Li PL. Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice. Am. J. Pathol. 179(5):2210-2219, 2011.
219. Studer, E, Zhou H, Zhao R, Wang Y, Takabe K, Nagahashi M, Pandak WM, Dent P, Spiegel, S. Xu W, Liu X. Bohdan, P, Zhang L, Zhou H, Hylemon PB.  Conjugated bile acids activate the sphingosine-1 phosphate 2 receptor in primary rodent hepatocytes.  Hepatology, 55(1):267-276, 2012.
220. Bajaj JS, Ridlon JM, Hylemon PB, Thacker LR, Heuman DM, Smith S, Sikaroodi M, Gillevet PM. Linkage of gut microbiome with cognition in hepatic encephalopathy. Am. J. Physiol. Gastrointest Liver Physiol. 302:G168-G175, 2012.
221. Ridlon JM, Hylemon PB. Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium. J. Lipid Res. 53:66-76, 2012.
222. Xu L, Shen S, Ma Y, Kim JK, Rodriguez Agudo D, Heuman DM, Hylemon PB, Pandak WM, Ren S. 25-Hydroxycholesterol-3-sulfate (25HCSC) Attenuates Inflammatory Response via PPAR gamma Signaling n Human THP-1 Macrophages.  Am. J. Physiol Endocrinol Metab. 302(7):E788-00, 2012.
223. Bajaj JS, Billevet PM, Patel NR, Ahluwalia V, Ridlon JM,  Kettenmann B., Schubert CM, Sikaroodi M, Heuman DM, Corssey MM, Bell DE, Hylemon PB, Fatouros PP, Taylor-Bobinson SD. A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalophathy. Metab Brain Dis 27(2)205-15, 2012.
224. Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, Gredler R, Shen XN, Robertson CL, Dumur Cl, Hylemon PB, Mukhopadhyay ND, Bhere D, Shah K, Ahmad R, Giashuddin S, Stafflinger J, Subler MA, Windle Jj, Fisher PB, Sarkar D. Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology 56(5):1782-91, 2012.
225. Bajaj JS, Hylemon PB, Ridlon JM, Heuman DM, Daita K, White MB, Monteith P, Noble NA, Sikaroodi M, Gillevet PM.  Colonic mucosal microbiome differs from stool microbiome in Cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am. J. Physiol Gastrointest Liver Physiol 303(6):G675-85, 2012.
226.  Bajaj JS. Hylemon PB, Z. Younossi. The Intestinal Microbiota and Liver Disease. The American Journal of Gastroenterology Supplements. 1:9-14, 2012.
227. Wang Y, Zhang L, Wu X, Gurley EC, Kennedy E, Hylemon PB, Pandak WM, Sanyal AJ, Zhou H. The role of C/EBP homologous protein in HIV protease inhibitor-induced hepatic lipotoxicity. Hepatology, 2012, Oct 18.
228. Bajaj JS, Gillevet PM, Hylemon PB. Methanogenesis in irritable bowel syndrome: a lot of hot air?  Dig.Dis Sci. 57(12)3045-46, 2012.
229. Zha W, Wang G, Xu W, Liu X, Wang Y, Zha BS, Shi J, Zhao Q, Gerk PM, Studer E, Hylemon PB, Pandak WM Jr, Zhou H.  Inhibition of P-glcoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.  PloS One 2013;8(1):e54349.
230. Hylemon PB, Nagahashi M, Takabe K, Allegood JC, Yamada A, Hait NC, Pandak WM, Spiegel S, Yang Y, Liu R, Zhou H.  Sphingosine-1-phosphate receptor 2: A key player in regulating hepatic glucose and lipid metabolism by conjugated bile acids.  XXII international Bile Acid Meeting-Hepatic and Extrahepatic Targets of Bile Acid Signaling. Falk Symposium 184:, Vienna, 2012, pp 53-58.
231. Kakiyama G, Pandak WM, Gillevet PM, Hylemon PB, Heuman DM, Daita K, Takei H, Muto A, Nittono H, Ridlon JM, White MB, Noble NA, Monteith P, Fuchs M, Thacker LR, Sikaroodi M, Bajaj JS. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol. 2013 May;58(5):949-55. PMC3936319
232. Zha W, Wang G, Xu W, Liu X, Wang Y, Zha BS, Shi J,Zhao Q, Gerk PM, Studer E, Hylemon PB, Pandak WM Jr, Zhou H. Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages. PLoS One. 2013;8(1):e54349.  PMC3553168
233. Bajaj JS, Heuman DM, Sanyal AJ, Hylemon PB, Sterling RK, Stravitz RT, Fuchs M, Ridlon JM, Daita K, Monteith P, Noble NA, White MB, Fisher A, Sikaroodi M, Rangwala H, Gillevet PM. Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One. 2013;8(4):e60042  PMC3615021
234. Ridlon JM, Ikegawa S, Alves JM, Zhou B, Kobayashi A, Iida T, Mitamura K, Tanabe G, Serrano M, De Guzman A, Cooper P, Buck GA, Hylemon PB. Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens. J Lipid Res. 2013 Sep;54(9):2437-49. PMC3735941
235. Ridlon JM, Alves JM, Hylemon PB, Bajaj JS. Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship. Gut Microbes. 2013 Sep-Oct;4(5):382-7. PMC3839982
236. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, Monteith P, Noble NA, Unser AB, Daita K, Fisher AR, Sikaroodi M, Gillevet PM. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol. 2014 May;60(5):940-7. doi: 10.1016/j.jhep.2013.12.019. Epub 2013 Dec 25. PMID: 24374295
237. Zhang X, Cao R, Liu R, Zhao R, Huang Y, Gurley EC, Hylemon PB, Pandak WM, Wang G, Zhang L, Li X, Zhou H. Reduction of the HIV protease inhibitor-induced ER stress and inflammatory response by raltegravir in macrophages.  PLoS One. 2014 Mar 13;9(3):e90856 PMC3953206
238. Ridlon JM, Kang DJ, Hylemon PB, Bajaj JS. Bile acids and the gut microbiome. Curr Opin Gastroenterol. 2014 May;30(3):332-8. PMID: 24625896
239. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, Puri P, Sterling RK, Luketic V, Stravitz RT, Siddiqui MS, Fuchs M, Thacker LR, Wade JB, Daita K, Sistrun S, White MB, Noble NA, Thorpe C, Kakiyama G, Pandak WM, Sikaroodi M, Gillevet PM. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther. 2014 May;39(10):1113-25. PMID: 24628464
240. Kakiyama G, Hylemon PB, Zhou H, Pandak WM, Heuman DM, Kang DJ, Takei H, Nittono H, Ridlon JM, Fuchs M, Gurley EC, Wang Y, Liu R, Sanyal AJ, Gillevet PM, Bajaj JS. Colonic inflammation and secondary bile acids in alcoholic cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G929-37. PMID: 24699327
241. Liu R, Zhao R, Zhou X, Liang X, Campbell DJ, Zhang X, Zhang L, Shi R, Wang G, Pandak WM, Sirica AE, Hylemon PB, Zhou H. Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. Hepatology. 2014 Sep;60(3):908-18. PMID:24700501
242. Zhou H, Hylemon PB. Bile acids are nutrient signaling hormones. Steroids. 2014 Aug;86:62-8.PMID: 24819989
243. Srivastava J, Robertson CL, Rajasekaran D, Gredler R, Siddiq A, Emdad L, Mukhopadhyay ND, Ghosh S, Hylemon PB, Gil G, Shah K, Bhere D, Subler MA, Windle JJ, Fisher PB, Sarkar D. AEG-1 regulates retinoid X receptor and inhibits retinoid signaling. Cancer Res. 2014 Aug 15;74(16):4364-77. PMID: 25125681
244. Bajaj JS, Cox IJ, Betrapally NS, Heuman DM, Schubert ML, Ratneswaran M, Hylemon PB, White MB, Daita K, Noble NA, Sikaroodi M, Williams R, Crossey MM, Taylor-Robinson SD, Gillevet PM. Systems Biology Analysis of Omeprazole Therapy in Cirrhosis Demonstrates Significant Shifts in Gut Microbiota Composition and Function. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 25. PMID:25258407