Publications

Journals

  1. Fu S., Zhu M., Wang Y. *Le Y. (2014) Efficient induction of productive Cre-mediated recombination in RPE. (Invited Research Article)Mol Vis20:480-487 http://www.molvis.org/molvis/v20/480.
  2. Dong S., Liu. Y.; Zhu, M., Xu, X., *Le, Y. (2014) Simplified system to investigate alteration of retinal neurons in diabetes. Adv Exp Med Biol. 801:139-43. (doi: 10.1007/978-1-4614-3209-8_18). PMID: 24664691.
  3. Ramamurthy V., Jolicoeur C., Koutroumbas D., Mühlhans J., Le Y., Hauswirth, W.W., Gießl A., Cayouette M. (2014) Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia, J. Neurosci. (In press).
  4. Mao H, Seo SJ, Biswal MR, Li H, Conners M, Nandyala A, Jones K, charffetter- Kochanek K., Le Y, Lewin AS. (2014) Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest. Ophthalmol. Vis. Sci. 55:4613-27. (doi: 10.1167/iovs.14-14633).
  5. Biswal M.R., Idelfonso C., Mao H., Seo S.J., Wang Z., Li H., Le Y, Lewin AS. (2015) Conditional Induction of Oxidative Stress in RPE: a Mouse Model of Progressive Retinal Degeneration.Adv Exp Med Biol. (Accepted).
  6. Wang J. Zhu M.  *Le Y.(2014) Essential role for Müller cells in microvascular complication in diabetic retinopathy. World J. Diabetes (Accepted).
  7. Fu S., Zhu M., Ash J.D., Wang Y. *Le Y. (2014) Investigating the role of retinal Müller cells with approaches in genetics and cell biology., Adv Exp Med Biol. 801:401-5. (doi: 10.1007/978-1-4614-3209-8_51) PMID:24664724.
  8. Grabner C., Rehak R., Le Y., Zamponi. GW., Schmit F., Schmitz, F. (2014) Signaling between RIM1/2 and L-type Ca2+ Channels is Required for Normal Voltage-Dependent Ca2+ Entry into Rod Photoreceptor Terminals. Nat. Neurosci (under review).
  9. *Le Y., Zhu M., Anderson, R.E. (2015) Cre recombinase: you can’t live with it, and you can’t live without it. Adv Exp Med Biol. (Accepted).
  10. Luo L., Uehara H., Olsen T., Das K.S., Zhang X., Simonis J.M, Jackman K., Archer B., Singh N., Miya T., Huang W., Ahmed F., Liu Y., Ambati J., Mamalis C., Chiodo V.A., Hauswirth W.W., Ferrara N., Baffi J., Gao G., Zygmunt K. Whitaker R., Lacal P.M., Orecchia A., Fu Y., Le Y., Jones A.D., Owen L., Holt D., Albuquerque R., Baehr W., Thomas K., Li D., Chalam K.C., Shibuya. M., Grisanti S., Wilson D.J., Ambati B.K. (2013). Photoreceptor Avascular Privilege is shielded by soluble VEGF receptor-1. eLife 2:e00324 (doi: 10.7554/eLife.00324). PMC3687373.
  11. Nasonkin I.O., Merbs S.L., Lazo K., Oliver V.F., Brooks M., Patel K., Enke R.A., Nellissery J., Jamrich M., Le Y., Bharti K., Fariss R.N., Rachel R.A., Zack D.J., Rodriguez-Boulan E.J., Swaroop R. (2013) Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis, Development140: 1330-41.PMC3585665.
  12. Chen Y., Yu Sawada O., Kohno H., Le Y., Subauste C., Maeda T., Maeda A. (2013) Autophagy protects the retina from light-induced degenerationJ. Biol. Chem.288: 7506-18.PMC3597791
  13. He C., Zhu H., Zhang W., Okon I., Wang Q. Li H., Le Y. , Xie Z. (2013) 7-ketocholesterol Induces Autophagy in Vascular Smooth Muscle Cells through Nox4 and Atg4B. J. Am. Pathol.183:626-37. PMC3730774.
  14. Siegert S., Cabuy E., Scherf B.G., Kohler H., Panda S., Le Y., Fehling H.J., Gaidatzis D., Stadler M.B., Roska B. (2012) Optional code and disease map for adult retinal cell types. Nat Neurosci. 15:487-95. (doi: 10.1038/nn.3032). PMID:22267162.
  15. Lin M., Hu Y., Chen Y., Zhou K., Jin J., Zhu M., Le Y., Ge J., Ma J.X. (2012) Impacts of Hypoxia-inducible Factor-1 Knockout in the Retinal Pigment Epithelium (RPE) on Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 53:6197–6206.
  16. Zhu, M., Bai, Y., Zheng, L. *Le, Y. (2012) Presence of RPE-produced VEGF in a timely manner is critical to choroidal vascular development. Adv Exp Med Biol.  723:299-304. PMID:22183346
  17. Zhong Y., Li J. Wang, J.J., Chen C., Tran JT, Saadi A, Yu Q, Le Y., Mandal N.A. Anderson R.E., Zhang S.X. (2012) X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium. PLoS One7(6):e38616.PMC3371004.
  18. Xu H., Liu J., Xiong S. Le Y., Xia X. (2012) Suppression of Retinal Neovascularization by Lentivirus-Mediated Netrin-1 Small Hairpin RNA. Ophthalmic Res 47:163-169 (DOI:10.1159/000331428). PMC3251241.
  19. Xu H., Song Z., Fu S., Zhu M., *Le Y. (2012) RPE barrier breakdown in diabetic retinopathy: seeing is believing.  J. Ocular Biology, Diseases and Informatics 4:83–92. (DOI 10.1007/s12177-011-9068-4). PMC3342408.
  20. Keady B., Le Y., Pazour, G (2011) IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol. Biol. Cells22: 921-30.PMC3069017.
  21. *LeY. (2011) Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations. J. Ophthalmol. (doi:10.1155/2011/806783).PMC3021885.
  22. Lin M., Chen Y., Jin J., Hu Y., Zhou K., Zhu, M., Le Y., Ge J., Ma J.X. (2011) The role of retinal Müller cell-derived hypoxia-inducible factor-1 in retinal inflammation and neovascularization in diabetic retinopathy.  Diabetologia54:1554-66.
  23. *Kusari J. (co-corresponding author), Padillo E.U., Zhou S., Ni M., Lalwani K., Bai Y. Wang J., Song, Z. Zhu M. *Le Y. (co-corresponding author), Gil D.W. (2011) Effect of Brimonidine on Retinal and Choroidal Neovascularization in Animal Models of Age-Related Macular Degeneration and Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 52:5424-31. PMC3176033
  24. Xu H., *Le Y. Visualizing diabetes- and ischemia-induced breakdown of outer blood-retina barrier (2011) Invest. Ophthalmol. Vis. Sci. 52:2160-4. PMC3080181.
  25. Ivanovic I., Anderson R.E., Le Y., Fliesler S., Sherry D., Rajala R. (2011) Deletion of the p85α Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration. Invest. Ophthalmol. Vis. Sci. 52:3775-83. PMC3109053.
  26. Lange C., Heynen S., Tanimoto, N., Le Y., Meneau I., Seeliger M.W., Samardzija M., Grimm C. (2011) Normoxic activation of hypoxia inducible factors in photoreceptors provides transient protection against light induced retinal degeneration Invest. Ophthalmol. Vis. Sci. 52:5872-80.
  27. Ivanovic I., Rajala A., Gupta V., Dighe R., Le Y., Anderson R.E., Rajala R. (2011) Phosphoinositide 3-Kinase Signaling in Retinal Rod Photoreceptors. Invest. Ophthalmol. Vis. Sci. 52:6355-62. PMC3176013
  28. Liu J., Xia X., Xiong S. Le Y., Xu H. (2011) Intravitreous high expression level of netrin-1 in patients with proliferative diabetic retinopathy. Eye Science (Yan Ke Xue Bao) 26 (2):35-42. NIHMSID # 391961.PMC3445338.
  29. Le Y. (2010) Computer-assisted semi-quantitative analysis of choroidal density. Adv Exp Med Biol.664:349-53. PMID: 20238035
  30. Wang J., Xu X., Elliott M.H. *Le Y. (2010) Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage.Diabetes59: 2297-2305. PMID: 20530741, PMC2927953.
  31. *Le, Y. Bai, Y., Zhu, M., Zheng, L. (2010) Temporal requirement of RPE-derived VEGF in the formation of choroidal vasculature. J. Neurochem.112: 1584–1592. PMID: 20067573; PMC2933813.
  32. Zhu M., Zheng L., Ueki Y., Ash J.D., *Le Y. (2010) Unexpected transcriptional activity of the human VMD2 promoter in retinal development. Adv Exp Med Biol.664: 211-216. PMID: 20238019
  33. Bai Y., Ma J., Guo J., Wang J., Zhu M., Chen Y., *Le Y. (2009) Müller cell-derived VEGF is a significant contributor to retinal neovascularization (cover article). J. Pathol.219:446-454. PMID: 19768732
  34. Ueki Y.,Le Y., Chollangi S., Müller, W., Ash J.D., (2009) Preconditioning-induced protection of photoreceptors requires cell autonomous activation of the signal-transducing receptor gp130. Proc Natl. Acad. Sci. USA106: 21389–21394. PMID: 19948961; PMC2785722.
  35. Avasthi P., Watt C., Williams D., Le Y., Li S., Chen C., Frederick J., Baehr, W. (2009) Heterotrimeric Kinesin-II Mediates Trafficking of Membrane Proteins to Cone, but not Rod Outer Segments. J. Neurosci29:14287–14298. PMID: 19906976; PMC2788486.
  36. Haruta M., Bush R.A., Kjellstrom, S., Le Y., Camasamudram V., Sieving P.A. (2009) Depleting Rac1 component of NADPH oxidase in mouse photoreceptors protects from photo-oxidative stress without affecting rod structure. Proc Natl. Acad. Sci. USA. 106:9397-9402. PMID: 19470639; PMC2685247.
  37. Ueki Y., Ash J.D.,Zhu M., Zheng, L., *Le Y. (2009) Expression of Cre recombinase in the retinal Müller cells (cover article). Vis. Res.49: 615–621 (doi:10.1016/j.visres.2009.01.012). PMID: 19948109; PMC2787478.
  38. Li F., Wicker L.D., Brush R.S., Elliott M.H., Le Y., Henry K.A., Anderson A.G., Zhao C., Sun X., Zhang. K., Anderson R.E. DHA does not protect ELOVL4 transgenic mice from retinal degeneration (2009) Mol. Vis. 15:1185-1193http://www.molvis.org/molvis/v15/a126. PMID: 19536303; PMC2697457.
  39. Thiersch M., Lange C., Joly S., Heynen S., Le Y., Samardzija, M. Grimm C. (2009) Retinal neuroprotection by hypoxic preconditioning is independent of HIF-1a expression in photoreceptors. European J. Neurosci 29: 2291–2302. PMID: 19508692
  40. *LeY., Zheng W., Rao P., Zheng L., Anderson R.E., Esumi N., Zack, J.D., Zhu M., (2008) Inducible expression of Cre recombinase in the RPE. Invest Ophthalmol Vis Sci.49: 1248-1253. PMID: 18326755; PMC2711689.
  41. Rajala A., Tanito M, Le Y., Kahn. R. C., Rajala, R.V. (2008) Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J. Biol Chem283:19781-92. PMID: 18480052; PMC2443670.
  42. Zheng L., Anderson R.E., Agbaga M., Rucker III E.B., *LeY. (2006) Loss of BCL-XL; increased rod photoreceptor susceptibility to bright light damage. Invest Ophthalmol Vis Sci.47: 5583-5589. PMID: 17122152.
  43. *Le Y., Zheng L., Zheng, W., Ash, J.D., and Anderson, R. E. (2006) Mouse opsin promoter controlled expression of Cre recombinase in transgenic mice, Mol Vis12: 389-398. PMID: 16636658.
  44. *Le Y., Ash, J.D., Al-Ubaidi, M.R., Chen, Y., Ma, J., and Anderson, R. E. (2004) Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice Mol Vis10:1011-1018. PMID: 15635292.
  45. Le Y., Gagneten, S., Larson, T., Santha, E., Dobi, A., Agoston, D. and Sauer B. (2003) Far-upstream elements are dispensable for tissue-specific proenkephalin expression using a Cre-mediated knock-in strategy. J. Neurochem. 84: 689-697. PMID: 12562513
  46. Le, Y., Miller, J.and Sauer, B. (1999). GFPcre Fusion Vectors with Enhanced Expression. Anal. Biochem., 270:334-336. PMID: 10334853.
  47. Le, Y.,Gagneten, S., Tombaccini, D., Betheke, B. and Sauer, B. (1999). Nuclear targeting determinants in the Cre recombinase of phage P1. Nucleic Acids Res., 27:4703-4709. PMID: 10572169.
  48. Chute, I., Le, Y., Ashley, T. and Dobson, M.J.(1997)The telomere-associated DNA from the short arm of human chromosome 20 contains a pseudotelomere structure and shares sequences with the subtelomeric regions of 4q and 18p. Genomics, 46, 51-60. PMID: 9403058
  49. Gagneten, S., Le Y., Miller, J.and Sauer, B. (1997) Brief expression of a GFPcrefusion gene in embryonic stem cells allows rapid retrieval of site-specific genomic deletions (cover-article). Nucleic Acids Res., 25, 3326-3331. PMID: 9241248
  50. Le, Y. and Dobson, M.J. (1997) Stabilization's of yeast artificial chromosome clones in a rad54 recombination-deficient host strain. Nucleic Acid Res. 25, 1248-1253. PMID: 9092636
  51. Le, Y., Smith, K.C., Vining, L.C. and White, R.L. (1996) Mutants ofStreptomyces akiyoshiensis blocked in 5-hydroxy-4-oxonorvaline production. J. Antibiot., 49, 107-109. PMID: 8936306
  52. Le, Y., He, J. and Vining, L.C. (1996) Streptomyces akiyoshiensis differs from other Gram-positive bacteria in the organization of a core biosynthetic pathway gene for aspartate family amino acids.  Microbiol.142, 791-798. PMID: 8609075.
  53. Smith, K.C., White, R.L. Le Y., Vining, L.C. (1995) Isolation of N-acetyl-3,4-dihydroxy-L-phenylalanine from Streptomyces akiyoshiensis. J. Nat. Prod.58, 1274-1277.
  54. *Le Y. (1994) Biosynthesis of 5-hydroxy-4-oxonorvaline. Ph.D. Thesis, Dalhousie University, Canada.
  55. *Le, Y, Zhu. S. (1988) Purification of restriction endonuclease MspI. Huaxue Shiji10, (1) 35-37.
    56. *: Le Y as corresponding author.

Methodology Reviews 

  1. Le, Y. and Sauer, B. (2001)Conditional gene knockout using Cre recombinase. In Mol Biotechnol. Humana Press, Totowa, NJ. 17(3):269-75. PMID: 11434315.
  2. Le Y. and Sauer, B. (2000) Conditional gene knockout using Cre recombinase. In Methods in Molecular Biology: Protocol in Developmental Biology, Tuan R.S. and Lo C.W. eds. Humana Press, Totowa, NJ. 136: II,477-485. PMID: 10840735.
Books and Book Chapters
  1. Ueki Y., Chollangi S., Le Y., Ash J.D. (2010) gp130 Activation in Müller Cells is not Essential for Photoreceptor Protection from Light Damage. In Retinal Degenerations: Mechanisms and Experimental Therapy. Anderson, R.E. et al. eds. Kluwer Academic/Plenum Publishers (New York): pp 655-661. PMID: 20238070
  2. *LeY., Zheng L., Le, Y. Rucker III E.B., Anderson R.E. (2008) Role of BCL-XL in rod and cone photoreceptor survival. In Retinal Degenerations: Mechanisms and Experimental Therapy. LaVeil. M.M. et al. eds. Kluwer Academic/Plenum Publishers (New York): pp 69-74. PMID: 18188930.
  3. *Le Y., Ash, J.D., Al-Ubaidi, M.R., Chen, Y., Ma, J., and Anderson, R. E. (2006) Conditional knockout system in photoreceptor cells. In Retinal Degenerations: Mechanisms and Experimental Therapy. Hollyfield J. G. et al eds. Kluwer Academic/Plenum Publishers (New York): pp 173-178. PMID: 17249572
    *: Le Y. as corresponding author.

Non-authored publications

  1. Magarvey N.A., Demain A.L. (2013) A tribute to Leo C Vining.J Antibiot (Tokyo) 66:359-360.
  2. Clark N.A. (2011) Yun-Zheng Le, Ph.D.: Challenging the outcomes of diabetic retinopathy,Forefront, American Diabetes Association Magazine8 (1):21-22.
  3. Koury C.B. (2007) Genetic system offer option for studying the role of retinal Müller cells-Cover-story-editorial onY. Le’s research. Retina TodayI (Sept/Oct):31.

National and International Meetings/Abstracts

  1. Le Y.Zhu, M. Fu. S. An essential role for Müller cells in neuro-protection in diabetic retinopathy (platform presentation), 17th Afro-Asia Congress of Ophthalmology, September 17-21, 2014, Xian, china.
  2. Le Y., Zhu, M.,Anderson R.E. Cre recombinase: you can’t live with it, and you can’t live without it. XVI International Symposium on Retinal Degeneration,July 13-18, 2014.Pacific Grove, California, USA.
  3. Biswal M.R., Wang Z., Mao H., Li H.,Le.Y., Lewin A. Reversal of oxidative stress in a mouse model of dry AMD. XXI Biennial Meeting of the International Society for Eye Research, July 20-24. 2014, San Francisco, California, USA.
  4. Li L., Rao, K.N., Le Y., Hurd T.W., Delgado C.L., Khanna, H. Ablation of the Retinitis Pigmentosa 2 (Rp2) gene results in cone photoreceptor defect and aberrant microtubule dynamics. XXI Biennial Meeting of the International Society for Eye Research, July 20-24. 2014, San Francisco, California, USA.
  5. Le Y. RPE barrier, does it matter? Special Interest Group, (Organizer, Moderator, and Speaker) Annual Meeting of the Association for Research in Vision and Ophthalmology, May 4-9, 2014, Orlando, Florida, USA.
  6. Le Y., Zhu, M. Efficient induction of productive Cre-mediated recombination in the retinal pigment epithelium (Platform presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 4-9, 2014, Orlando, Florida, USA.
  7. Le Y., Cellular and molecular mechanisms in channeling signals for retinal neuron survival in diabetic retinopathy (platform presentation), 9th International Symposium of Ophthalmology, November 9-11, 2013, Guangzhou, China.
  8. Le Y., Zhu M. Molecular and cellular interplay in channeling signals for retinal neuron survival in diabetes, 73 Scientific Session of America Diabetes Association, June 21-25, 2013. Chicago, Illinois, USA.
  9. Zhu M., Le Y.Testing the effect of RPE barrier function regulators in vitro and in vivo. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 6-10, 2013, Seattle, Washington, USA.
  10. Le Y.VEGF receptor-2 mediated neuro-protection is required for cone photoreceptor survival und hypoxic condition. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 6-10, 2013, Seattle, Washington, USA.
  11. Le Y., Fu S. Xu H. Liu Y. Zhu M: Measurement of RPE barrier leakage de novo: usefulness in investigating mechanism and therapeutics for diabetic retinopathy. XX Biennial Meeting of the International Society for Eye Research, July 21-25, 2012, Berlin, Germany.
  12. Schultz R., Menning J., Ristow M. Le Y., Witte O.W., Schmeer C.: Frataxin overexpression in retinal Müller cells increases neuronal survival after acute retinal ischemia/reperfusion in vivo.  XX Biennial Meeting of the International Society for Eye Research, July 21-25, 2012, Berlin, Germany.
  13. Zhu M., Fu S., Dong S., Le. Y.:Müller cell integrity is essential to retinal neurons in diabetes. XVth International Symposium on Retinal Degeneration. July 16-21, 2012 Bad Gögging, Bavaria, Germany.
  14. Le. Y. Fu S., Shi K., Dong S. Zhu M. Mechanism of Photoreceptor survival in diabetes. XVth International Symposium on Retinal Degeneration. July 16-21, 2012 Bad Gögging, Bavaria, Germany.
  15. Le Y., Shi K. (2012) Rod degeneration accelerates cone photoreceptor death in diabetes, 72 Scientific Session of America Diabetes Association, June 8-12, 2012. Philadelphia, Pennsylvania, USA.
  16. Luo L., Olsen T., Zhang X., Das S., Uehara H., Singh N., Miya T., Archer B., Le. Y., Ambati B.K.: Selective Cre/lox Flt-1 Ablation In RPE Induces CNV: A Novel Transgenic Murine CNV Model. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  17. Le Y. Song Z. Xu H., Carr D.J., Zhu M.: Modulating The Severity Of Uveitis By Altering RPE Barrier Function: Implication In Therapeutics. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  18. Ferreira P.A., Saha A., Haque E., Le Y., Webb M.: Conditional Knock-Out of Ran-binding protein 2 (RanBP2)/Nucleoporin 358 (NUP358) in the Retinal Pigment Epithelium Results in the Activation of Membrane to Nuclear Signaling Pathways and Hallmark Features of Age-Related Macular Degeneration (AMD) (platform presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  19. Shi K., Le Y.: Cone Photoreceptors Are Vulnerable To Diabetes-induced Rod Photoreceptor Death. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  20. Hsu Y.C., Chuang J.Z. Chen J., Yan Y.T., Le Y. Sung C.H.: Sara Regulates Opsin Trafficking And Outer Segment Morphogenesis. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  21. Fu S., Dong S. Le. Y. Müller Cell Is A Major Cellular Source Of Survival Signals For Photoreceptors In Diabetes. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  22. Lewin A.S., Krebs M.P. Gibson S., Jones K. Mao H., Le Y., Hauswirth W.: Image Registration Reveals Sites of Injury from Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
  23. Le Y., Fu S. Xu H.: Fluorescent Microscopic Imaging for RPE Barrier Leakage de novo: Simple Technology Addresses Important Issue In Diabetic Retinopathy (platform presentation). ARVO/ISIE Imaging Conference. May 4, 2012, Ft. Lauderdale, Florida, USA
  24. Le Y., Fu S. Xu H. Zhu M.: Normal interaction between the RPE and choroidal vasculature is critical to retinal integrity. Annual Conference of Arnold and Mabel Beckman Initiative for Macular Research, January 25-29, 2012, Irving, California, USA.
  25. Le Y., Fu S. Zhu M. Abnormal interaction between RPE and choriocapillaris causes age-dependent photoreceptor degeneration: implication in dry-AMD (Invited Platform Presentation) Annual Foundation Fighting Blindness Center Meeting, October, 14-15, 2011, Houston, Texas, USA.
  26. Le Y., Liu Y.; Zhu M.; Hui X: Significance of Diabetes-induced Outer Blood-retina Breakdown and its Relevance to Diabetic Macular Edema, 71st Scientific Session of America Diabetes Association, June 24-28, 2011. San Diego, California, USA.
  27. Le Y., Liu Y., Zhu M., Hui X: Imaging Diabetes-induced Outer Blood-retina Breakdown: Implications in Diagnosis and Treatment of Diabetic Macular Edema. (Moderator)Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
  28. Soojung S., Le Y., Conners M.S., Jones K.D., Hauswirth W.,Lewin A., Generation of Early AMD Mouse Model by Induction of Oxidative Stress.Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
  29. Barabas P., Liu A., Xing W., Tong Z., Le Y., Anderson R.E., Zhang K.,Bernstein P.S., Krizaj D.: Conditional Ablation of Retinal Elovl4 Reveals a Key Role in Synthesis of VLC-PUFAs and Photoreceptor Light Responses.Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
  30. Li, J.,Zhong Y., Wang, J.J.,Le Y.Mandal N.A. Zhang S.X.: Loss Of Xbp1 In The Aging RPE Reduces Autophagy And Exacerbates RPE Cell Death: A Novel Mechanism For Age-related Macular Degeneration(platform presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
  31. Le Y., Liu Y.; Zhu M.; Hui X.: Visualizing and Quantifying Outer Blood-Retina Barrier Breakdown: Implications in Finding a Cure for Macular Edema.10th Scientific Meeting of Association for Ocular Pharmacology and Therapeutics(platform presentation). February 17-20, 2011, Fort Worth, Texas, USA.
  32. Le Y., Zheng L., Bai Y., Zhu, M.: Mechanisms of atrophic AMD. 3rd Annual Conference of Arnold and Mabel Beckman Initiative for Macular Research, January 20-22, 2011, Irving, California, USA
  33. Le Y., Hui X.: Visualizing Outer Blood-Retina Barrier Breakdown Under Pathological Conditions. XIX Biennial Meeting of the International Society for Eye Research (platform presentation), July 18-23, 2010. Montreal, QC, Canada.
  34. Le Y., Hui X.: Pathophysiology Of Outer Blood-Retina Barrier Breakdown. XIX Biennial Meeting of the International Society for Eye Research, July 18-23. 2010, Montreal, QC, Canada.
  35. Zhang S.X., Zhong Y., Li, J., Le Y. Wang, J.J.: Transcriptional Regulation of Anti-Oxidant Genes in the RPE. XIV International Symposium on Retinal Degeneration (platform presentation) July 13-17, 2010 MontTremblant, QC, Canada.
  36. Le Y., Zheng L. Bai Y., Zhu M.: Choroidal circulation and geographic atrophy. XIV International Symposium on Retinal Degeneration. July 13-17, 2010, Mont Tremblant, QC, Canada.
  37. Gibson S., Lewin A., Liu, J, Le Y., Hauswirth W.: Generation of mouse model of atrophic retinal degeneration by induction of oxidative stress. XIV International Symposium on Retinal Degeneration (platform presentation). July 13-17, 2010, Mont Tremblant, QC, Canada.
  38. Le Y., Wang, J., Xu H.: Pathophysiology Of Outer Blood-Retina Barrier Breakdown (Session Moderator). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
  39. Zhong Y., Li J., Wang J. Le Y., Zhang S.: X-Box Binding Protein 1 is a Novel Regulator of Anti-Oxidant Genes in the RPE. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
  40. Barabas P., Huang W., Xing W., Rao A., Le Y., ChenC.-K.J., Krizaj D.: Store-Operated Calcium Entry Sustains Increased Calcium Level in Photoreceptor Cells and Affects Vision in the Mouse. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
  41. Lin M., Chen Y., Jin J., Hu Y., Zhou K., Zhu M., Le Y., Ma J.-X.: The Role of Müller Cell-Derived Hypoxia-Inducible Factor (HIF)-1 on Retinal Neovascularization. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
  42. Xu H. Le Y.: Cellular Mechanism and Treatment of Outer Blood-Retina Barrier Breakdown in Uveitis (Platform Presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
  43. Lewin A., Gibson S., Liu, J., Hauswirth W., Le Y.: Generation of a Mouse Model of Early AMD by Induction of Oxidative Stress. May 2-6, 2010, Ft. Lauderdale, Florida, USA.
  44. Baehr W., Watt C.B., Williams D.S., Le Y., Li S., Chen C-K., Frederick J.M., Avasthi P.: Heterotrimeric Kinesin-2 is Required for Trafficking of Membrane Proteins to Cone, but Not Rod, Outer Segments. FASEB summer research meeting, June 14-19, 2009.  Snowmass, Colorado, USA. 
  45. Ueki Y., Le Y., Wang, J., Chucair-Elliott, A., Ash, J.D.: Photoreceptor-specific knockouts of either gp130 or STAT3 accelerate inherited retinal degeneration: implication for chronic stress-induced neuroprotection. FASEB summer research meeting, June 14-19, 2009.  Snowmass, Colorado, USA.
  46. Guo J., Le Y.: Role of BCL-XL in Photoreceptor Survival Under Diabetes and Hypoxic Stress. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  47. Thiersch M., Lange C., Joly S., Le Y., Heynen S., Samardzija M., Grimm, C.: Hypoxia-Inducible-Factor 1a Ablation in a Model of Retinal Neuroprotection by Hypoxic Preconditioning. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
  48. Ueki Y., Le Y., Ash, J.D.: Activation of the Signal-Transducing Receptor gp130 in Photoreceptors Is Essential for Endogenous Protection From Retinal Degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  49. Seo S., Le Y. Hauswirth W., Lewin A.: Early AMD Mouse Model by Reduction of MnSOD2 Using the Cre-LoxP Recombination System. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  50. Baehr W., Watt C.B., Williams D.S., Le Y., Li S., Chen C-K., Frederick J.M., Avasthi P.: Heterotrimeric Kinesin-2 is Required for Trafficking of Membrane Proteins to Cone, but Not Rod, Outer Segments. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  51. Wang, J., Le Y.: The Role of the Müller Cell-Produced VEGF in Inflammatory Response During the Pathogenesis of Diabetic Retinopathy. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  52. Rajala R.V., Tanito M., Le Y., Allen D.T., Kahn R.C., Neel B.G., Rajala A.: Insulin Receptor Survival Signaling in Rod Photoreceptors Is Regulated Through Rhodopsin-Controlled Protein Tyrosine Phosphatase 1B Activity. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  53. IvanovicI., Le Y.Anderson, R.E., Rajala R.V.: Deletion of the p85 Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  54. Bai Y., Ma J.-X., Le Y.: The Role of Retinal Müller Cell-Produced VEGF in Ischemia Induced Vascular Leakage. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  55. Le Y., Guo J., Zhu M.: Genetic Disruption of Müller Cell-Produced VEGF Does Not Affect Retinal Development and Integrity: Implication in Anti-VEGF Therapeutics. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
  56. Le Y., Guo J., Wang J., Zhu, M.: Dissecting The Role Of Müller Cell-Produced VEGF In Diabetic Retinopathy.69th Scientific Session of AmericaDiabetes Association, June 5-9, 2009. New Orleans, Louisiana, USA.
  57. Zhu M., Zheng L., Ueki Y., Ash J.D., Le Y.: Expression of Cre recombinase in the retinal Muller cells. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
  58. Ash J.D., Chollangi S. Le Y., Ueki Y., Wang J.: The AKT Pathway is Required for Neuroprotection in the Retina from Acute Injury While the gp130/STAT3 Pathway is Required for Protection from Chronic Stress. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
  59. Baehr W., Le Y., Williams D., Frederick J., Avasthi P.:  Kinesin-II Regulates Intraflagellar Transport of Membrane-associated Proteins to the Cone Photoreceptor Outer Segments. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
  60. Ueki Y., Chollangi S. Wang J. Le Y., Ash J.D.: Signal-transducing Receptor gp130 is Essential for Endogenous Protection of Photoreceptors from Light Damage. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
  61. Le Y., Zheng L., Bai Y., Zhu, M.: Age-dependent photoreceptor degeneration caused by the loss of the RPE-produced VEGF. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
  62. Le Y., Zhu M, Bai Y.: Retinal Pigment Epithelium in Diabetic retinopathy. 68th Scientific Session of AmericaDiabetes Association, June 6-10, 2008. San Francisco, California, USA.
  63. Ash J.D., Ueki Y., Le Y., Chollangi S.:Evidence That Leukemia Inhibitory Factor (LIF) Protects Photoreceptors From Light Damage Independent Of Müller Cell Activation By LIF. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
  64. Le Y., Bai Y., Zhu M.: Relationship Between the RPE-Produced VEGF and the Outer Blood-Retina Barrier Function. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
  65. Avasthi P., Le Y., Williams D., Frederick J., Baehr W.: Kinesin-II Regulates Transport of Membrane-Associated Proteins to the Cone Photoreceptor Outer Segments. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
  66. Bai Y., Zhu M., Le Y.: Temporal Requirement of the RPE-Produced VEGF in Choroidal Development. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
  67. Rajala R., Rajala A., Le Y., Neel B. G. Tanito M: Enhanced Insulin Receptor Activated Neuroprotective Survival Signal in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene in Rod Photoreceptor Cells. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
  68. Le Y.: Function of the retinal Müller cell-produced VEGF in diabetic retinopathy. ARVO 2007 Summer Eye Research Conference, July 15-18, 2007, Warwick, Rhode Island, USA.
  69. Le Y., Ma J., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., and Zhu, M.: Role of the retinal Müller cells in retinal neovascularization. 67th Scientific Session of AmericaDiabetes Association, June 22-26, 2007. Chicago, Illinois, USA.
  70. LeY.: Contribution of the RPE to the bright light induced photoreceptor damages. FASEB summer research meeting, June 16-21, 2007.  Snowmass, Colorado, USA. 
  71. Le Y., Ma J., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., and Zhu, M: Role of the retinal Müller cells in retinal neovascularization (platform presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
  72. Rajala R., Le Y., Lee Y., Rajala A., Kahn R., and Tanito M: Photoreceptor Specific Deletion of Insulin Receptor Results in Light-Induced Retinal Degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
  73. Le Y.: Temporal and spatial gene activation and inactivation in the retina using Cre/lox strategies. Cre-driver Lines for Use in the Tissue-Specific Deletion of Genes in Multiple Ocular Tissues (invited as a platform presenter and moderator) - Special Interest Group. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
  74. Le Y., Zheng L., Anderson R.E., Agbaga M., Rucker III E.B., Le, Y., Zhu, M.: Role of anti-apoptotic protein BCL-XL in photoreceptor survival (invited as platform presentation), 2ndShanghai International Conference on Physiological Biophysics-Audition & Vision, November 3-7, 2006, Shanghai, China.
  75. Le Y., Ma J., Zheng L., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., Zhu, M.: Role of the RPE-produced VEGF In choriocapillaris integrity. XII International Symposium on Retinal Degeneration (platform presentation), October 23-28, 2006, San Carlosde Bariloche, Argentina.
  76. LeY., Zheng L., Agbaga M., Rucker III E.B., Anderson R.E.: Loss of BCL-XL causes increased rod photoreceptor susceptibility to bright light damage. XII International Symposium on Retinal Degeneration, October 23-28, 2006, San Carlos de Bariloche, Argentina.
  77. Zheng L., Anderson R.E., Agbaga M., Rucker III E.B., LeY.: Loss of BCL-XL causes increased rod photoreceptor susceptibility to bright light damage. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 4, 2006, Ft. Lauderdale, Florida, USA.
  78. Le Y., Zheng L., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., Ma J.: Function of the RPE-produced VEGF in the outer blood retina barrier. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 4, 2006, Ft. Lauderdale, Florida, USA.
  79. Le Y., Rao P., Zheng L., Chen Y., Zheng L., Gerber. H.P., Ferrara N., Anderson R.E., Esumi N., Zack D.J., Ma J.: Inducible RPE-specific gene knockout and its application in gene function analysis. FASEB summer research meeting. June 18-23, 2005.  Tucson, Arizona, USA. 
  80. Zheng L., Rao P., Zheng W., Le Y.: Glucose transport in the retina. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2005, Ft. Lauderdale, Florida, USA.
  81. Le Y., Rao P., Zheng L., Zheng W. Ash J.D., Esumi N., Zack J.D., Anderson R. E.: Inducible gene knockout system in the retinal pigmented epithelium. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2005, Ft. Lauderdale, Florida, USA.
  82. Zheng L., Rao P., Zheng W., Anderson R. E., Le Y.: Bcl-xl is involved in neuro-protection in the retina. April 1-2, 2005. Foundation Fight for Blindness, Southwest Regional Meeting, Dallas, Texas, USA.
  83. Le Y., Ash J.D., Al-Ubaidi M.R., Chen Y., Ma J.,Anderson R. E.: Conditional knockout system cone photoreceptor cells. XIth International Symposium on Retinal Degeneration, August 23 - 28, 2004, Perth, Western Australia.
  84. Le Y., Ash J.D., Al-Ubaidi M., Anderson, R.E.: Conditional knockout system in cone photoreceptor cells. Annual Meeting of the Association for Research in Vision and Ophthalmology.  April 25-29, 2004, Ft. Lauderdale, Florida, USA.
  85. Le Y., Kontas C., Agbaga M. Ash J.D., LaVail M.M., Anderson R.E.: Conditional Knockout Systems in Retinal Cells. FASEB summer research meeting. June 21-26, 2003.  Tucson, Arizona, USA. 
  86. Le Y., Kontas C., Agbaga M. Ash J.D., Anderson R.E.: Generation and characterization of photoreceptor-specific Cre transgenic mice. Annual Meeting of the Association for Research in Vision and Ophthalmology.  May 4-9, 2003, Ft. Lauderdale, Florida, USA.
  87. Le Y. Conditional gene expression in the retina. March 28-29, 2003, Foundation Fight for Blindness Southwest Regional Meeting, Houston, Texas, USA.
  88. Le Y., Agbaga M, Anderson, RE. Molecular cloning and expression of a phosphatidylinositol phosphate kinase from rat retina. Annual Meeting of Association for Research in Vision and Ophthalmology. May 2002, Fort Lauderdale, Florida, USA.
  89. Le Y. Cell-type specific knockout system in retina. April, 2002, Foundation Fight for Blindness Southwest Regional Meeting, Oklahoma City, Oklahoma, USA.
  90. Le Y., Gagneten S., D. Agoston D., Larson T., Sauer B: Expression of proenkephalin-lacZfusion gene in transgenic mice generated with a Cre-mediated knock-in strategy. IX International Symposium on Retinal Degeneration, October, 2000, Durango, Colorado, USA.
  91. Le Y., Gagneten S., Larson T., Sauer B.:  (invited): Nuclear target determinants of Cre DNA recombinase and the use of Cre-loxP system in manipulating mouse genome. The Second International Cao Tian-Qin Memorial Symposium on Protein Research, June, 2000, Shanghai, China.
  92. Soukharev S. Le Y., Sauer B: High frequency genomic targeting in ES cells by Cre recombinase. Conditional Genetic Technologies in the Mouse, FirstColdSpringHarbor Workshop on Emerging Technologies for Cancer Research. September, 1998, Cold Spring Habor, New York, USA.
  93. Le Y., Agoston D., Gagneten S., Larson T. Sauer B.: Functional dissection of the proenkephalin promoter in the mouse using Cre-mediated targeting. Mouse Molecular Genetics Meeting, September 1998, Cold Spring Habor, New York, USA.
  94. Le Y., Gagneten S. Larson T., Miller J, Sauer B.: Use of GFPcre fusion gene for FACS sorting of DNA "pop-outs" in ES cells and for tracing Cre expression in transgenic mice. NIH Research Festival, October, 1997, Bethesda, Maryland, USA.
  95. Le Y., Gagneten S. Larson T., Miller J, Sauer B.: Brief Expression of a GFPcre fusion gene in embryonic stem cells allows rapid retrieval of site-specific deletions. 17th International Congress of Biochemistry and Molecular Biology, August, 1997, San Francisco, California, USA.
  96. Dobson M.J., Le Y.,ChuteI.,Ashley T.: The telomere-associated DNA from the short arm of human chromosome 20 contains an interstitial tract of telomeric repeats. The First Canadian Telomere Workshop, May, 1997. Toronto, Ontario, Canada.
  97. Le Y., Dobson M. J.:Development and use of improved yeast artificial chromosome vectors and host strains: stabilization of yeast artificial chromosome clones in a rad54 recombination-deficient host strain.  Genome Canada 96, June, 1996. Ottawa, Ontario, Canada.
  98. Dobson, M. J., Le Y.:Development and use of improved yeast artificial chromosome vectors and host strains.  Genome Canada 95. April, 1995. Toronto, Ontario, Canada.
  99. Le Y., He J., Vining, L.C.:Cloning and sequence of the aspartate semialdehyde dehydrogenase gene from the 5-hydroxy-4-oxonorvaline producer, Streptomyces akiyoshiensis. 7th International Symposium on Genetics of Industrial Microorganisms.  June 1994. Montreal, Quebec, Canada.
  100. LeY. and Vining L.C.(invited): Biosynthesis of 5-hydroxy-4-oxonorvaline and asparatate family amino acids in Streptomyces akiyoshiensis. First International Workshop on Antibiotics "Antibiotics, 93". November, 1993, Havana, Cuba.
  101. Le Y., Wright J., Vining L.C., Smith K.C., White R.L.: Biosynthesis of 5-hydroxy-4-oxonorvaline:  location of the branch point in the aspartate family pathway. 42 Annual Canadian Society of Microbiologist meeting. June, 1992, St. John's, New foundland, Canada.
  102. Le Y., Smith K.C., Vining, L.C, White, R.L.: Isolation and Characterization of mutants blocked in the aspartate pathway and in the biosynthesis of 5-hydroxy-4-oxonorvaline. 8th International Symposium on Actinomycete Biology. August, 1991, Madison, Wisconsin, USA.

Invited talks

  1. Retinal pathobiology (acceptance lecture for a visiting professorship), September 3, 2014, Shanghai Jiaotong University School of Medicine, Shanghai, China. 
  2. Diabetic retinopathy, it is not just endothelial barrier breakdown, August 28, 2014, Li Ka Shing Faculty of Medicine, University of Hong Kong,Pokfulam, Hong Kong.
  3. Pathogenic mechanisms of diabetic retinopathy, perspectives from a cell biologist, November 13, 2013, Vascular Biology Center, Georgia Regents University, Augusta, Georgia, USA.
  4. Cellular mechanisms of diabetic retinopathy, November 6, 2013, Jiao-tong University affiliated Shanghai No. 6 Peoples’ Hospital, Shanghai, China.
  5. Dissecting the functions of VEGF: each protein has its Yin and Yang, March 14, 2013 Department of Ophthalmology, University of Oklahoma Health Sciences Center and Dean A. McGee Eye Institute, Oklahoma City, OK, USA.
  6. Diabetic retinopathy: it is not just endothelial barrier dysfunction, March 14, 2013 Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  7. Dissecting the mechanisms of diabetic complication in the retina, December 5, 2012, Loris and David Rich Endowed Lecture in Visual Science, the University of Alabama at Birmingham, Birmingham, Alabama, USA.
  8. Diabetic retinopathy: it is not just retinal vascular dysfunction, December 5, 2012, Department of Ophthalmology, the University of Alabama at Birmingham, Birmingham, Alabama, USA.
  9. What's new about the cellular mechanism of diabetes-induced blood-retina barrier breakdown? June 7, 2012, Wilmer Ophthalmological Institute, John Hopkins University School of Medicine, Baltimore, Maryland, USA.
  10. RPE Barrier Breakdown in Diabetes, seeing is believing, May 29, 2012, Annual Meeting of Shichuan Academy of Medical Sciences and Society of Ophthalmology, Chengdu, China.
  11. New Development in retinal biology research, May 28, 2012, Shichuan Provincial People’s Hospital, Chengdu, China.
  12. RPE Barrier Dysfunction in Diabetes, May 25, 2012, Tong-ji University School of Medicine, Shanghai, China.
  13. New trends in research for diabetic retinopathy, May 24, 2012, Shanghai Institute of Materia Medica, Academia Sinica,Shanghai, China.
  14. Pathological and beneficial roles of retinal Müller cells in diabetic retinopathy, May 21, 2012, Department of Ophthalmology, Jiao-tong University affiliated Shanghai No. 6 Peoples’ Hospital, Shanghai, China. 
  15. Diabetes-induced RPE barrier breakdown: seeing is believing. September 29, 2011, Symposium of Dean A. McGee Eye Institute New Research Building Dedication. Oklahoma City, OK, USA.
  16. Physiological and pathological functions of VEGF in the eye. May 26, 2011, Department of Ophthalmology, Medical School of University of Texas at Galveston, TX, USA.
  17. Dissecting the cellular mechanisms of diabetic retinopathy. December 2, 2010, Department of Cell Biology and Human Anatomy, University of California, Davis, California, USA.
  18. Lessons learned from mice about retinal biology and diseases. November 15, 2010, Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.
  19. The “good” and the “bad” side of VEGF. October 21, 2010. Department of Neural & Behavioral Sciences, PennsylvaniaStateUniversity, Hershey, Pennsylvania, USA.
  20. Diabetic retinopathy: Müller cells matter: a 3-cover-story tale. August 10, 2010. Shanghai Institute of Materia Medica, Academia Sinica,Shanghai, China.
  21. Essential role of Müller cells in retinal inflammation and vascular lesion: cellular mechanisms of diabetic retinopathy. July 31, 2010. Second Conference on the New Development in Ophthalmology. Department of Ophthalmology, Xiang-Ya Hospital of CentralSouthUniversity, Changsha, China.
  22. Cellular mechanism of VEGF action in the eye. June 7, 2010. Department of Pharmacology and Toxicology, University of MississippiMedicalCenter, Jackson, Mississippi, USA.
  23. Mechanisms of retinal degeneration and diseases. September 24, 2008. Department of Ophthalmology, Xiang-Ya Hospital of CentralSouthUniversity, Changsha, China.
  24. Cellular Mechanisms of diabetic retinopathy. November 29, 2007. Allergan Inc. Irvine, California.
  25. Temporal and spatial gene activation and inactivation in the retina using Cre/lox strategies. Cre-driver Lines for Use in the Tissue-Specific Deletion of Genes in Multiple Ocular Tissues-Special Interest Group. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
  26. Mechanisms of retinal degeneration and diseases. November 17, 2006. Institute of Neurobiology, FudanUniversity, Shanghai, China.
  27. Role of anti-apoptotic protein BCL-XL in photoreceptor survival, 2ndShanghai International Conference on Physiological Biophysics-Audition & Vision, November 3-7, 2006, Shanghai, China.
  28. Dissecting gene function in retinal degeneration and diseases. October 19, 2006. Department of Medicine, University ofOklahoma Health Sciences Center, Oklahoma City, OK, USA.
  29. Conditional gene expression and its use in gene function studies. July 23, 2004. Department of Medicine Endocrinology, University ofOklahoma Health Sciences Center, Oklahoma City, OK, USA.
  30. Use of Cre/lox system to study gene function in photoreceptor cells. October 18, 2001. OklahomaCenterfor Neuroscience, University ofOklahoma Health Sciences Center, Oklahoma City, OK, USA.
  31. The use of Cre recombinase to manipulate mouse genome. June 8, 2000. Shanghai Institute of Cell Biology, Academia Sinica, Shanghai, China.
  32. Nuclear target determinants of Cre DNA recombinase and the use of Cre-loxP system in manipulating mouse genome. June, 2000, The Second International Cao Tian-Qin Memorial Symposium on Protein Research, Shanghai, China.
  33. Site-specific Cre recombinase: tool for genomic engineering. March 8, 2000. FoxChaseCancerCenter, Institute for Cancer Research, Philadelphia, Pennsylvania, USA.
  34. Biosynthesis of 5-hydroxy-4-oxonorvaline and aspartate family amino acids in Streptomyces akiyoshiensis.November, 1993, First International Workshop on Antibiotics "Antibiotics, 93" (United Nation Supported). Havana, Cuba.

    35.  

Yun Le

Associate Professor of Research

 

  • :(405) 271-1087
  • DEPARTMENTMedicine Endocrinology and Harold Hamm Diabetes Center
    University of Oklahoma Health Sciences Center
  • COUNTRYCanada