Publications

• Michael C. Pirrung and Nicholas J.G. Webster. (1986) Cyclooctenonephotocycloadditions. Tetrahedron Letters 27 (34), 3983-3986.
• Michael C. Pirrung and Nicholas J.G. Webster. (1987) Mechanism of intramolecularphotocycloadditions of cyclooctenones. J. Org. Chem. 52, 3603-3613.
• Nicholas Webster, JiaRui Jin, Stephen Green, Melvin Hollis, and Pierre Chambon. (1988) The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell 52, 169-178.
• Nicholas J.G. Webster,  Stephen Green, JiaRui Jin, and Pierre Chambon. (1988) The hormone binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54, 199-207.
• Stephen Green, Nicholas J.G. Webster, JiaRui Jin, and Pierre Chambon. (1988) The use of chimeric proteins to study transcriptional regulatory factors. UCLA Symposium on DNA-Protein Interactions in Transcription, Ed. Jay D. Gralla, pp125-150.
• Nicholas J.G. Webster, Stephen Green, Diane Tasset, MathurosePonglikitmongkol, and Pierre Chambon. (1989) The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J. 8, 1441-1446.
• Lazlo Tora, John White, ChristelBrou, Diane Tasset, Nicholas Webster, and Pierre Chambon. (1989) The human estrogen receptor has two independent non-acidic transcriptional activation functions. Cell 59, 477-487. 
• R.ScottThies, Nicholas J. Webster, and Donald A. McClain. (1990) A domain of the insulin receptor required for endocytosis in rat fibroblasts. J. Biol. Chem. 265, 10132-10137.
• YasumitsuTakata, Nicholas J.G. Webster, and Jerrold M. Olefsky. (1991) Mutation of the two carboxy-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J. Biol. Chem. 266, 9135-9139.
• YasumitsuTakata, Nicholas J.G. Webster, and Jerrold M. Olefsky. (1992) Intracellular signaling by a mutant insulin receptor lacking the carboxyl terminal tyrosine autophosphorylation sites. J. Biol. Chem. 267, 9065-9070.
• Katherine E. Cameron, Jamie Resnik, and Nicholas J.G. Webster. (1992) Transcriptional regulation of the human insulin receptor promoter.  J. Biol. Chem. 267, 17375-17383.
• Nicholas J.G. Webster, Katherine E. Cameron, James G. Nelson, Christen M. Anderson, Jamie Resnik, and Jorge M. Uribe. (1992) "The insulin receptor: structure, function, and regulation" in New Perspectives in Endocrinology, Editors A. DeBellis and K.B. Marschke, Raven press, New York, p337-354.
• Christen M. Anderson, Robert R. Henry, Paul E. Knudson, Jerrold M. Olefsky, and Nicholas J.G. Webster. (1993) Relative expression of insulin receptor isoforms does not differ in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J. Clin. Endocrinol. Metab. 76, 1380-1382.
• Gary C. Rolband, Jeffrey F. Williams, Nicholas J.G. Webster, and Jerrold M. Olefsky. (1993) Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling. Endocrinology 133, 1437-1443.
• Atsushi Kosaki and Nicholas J.G. Webster. (1993) Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J. Biol. Chem. 268, 21990-21996.
• PerlaKaliman, Veronique Baron, Francoise Alengrin, YasumitsuTakata, Nicholas J.G. Webster, Jerrold M. Olefsky, and Emmanuel Van Obberghen. (1993) The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry 32, 9539-9544.
• Gary C. Rolband, Jeffrey F. Williams, Nicholas J.G. Webster, David Hsu, and Jerrold M. Olefsky. (1993) Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling. Biochemistry 32, 13545-13550.
• Nicholas J.G. Webster, Yan Kong, Katherine E. Cameron, and Jamie Resnik. (1994) An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBPb and NF-1. Diabetes 43, 305-312.
• Hongjiang Wu, David J. Rozansky, Nicholas J.G. Webster, and Daniel T. O'Connor. (1994) Cell type-specific gene expression in the neuroendocrine system. J. Clin. Invest. 94, 118-129.
• Hongjiang Wu, SushilMahata, ManjulaMahata, Nicholas J.G. Webster, Robert J. Palmer, and Daniel T. O'Connor. (1995) A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. J. Clin. Invest. 96, 568-578.
• Atsushi Kosaki, Tahir S. Pillay, LanXu, and Nicholas J.G. Webster. (1995) The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells. J. Biol. Chem. 270, 20816-20823.
• Talia Nur, IlanSela, Nicholas J.G. Webster, and ZechariaMadar. (1995) Starvation and refeeding regulate glycogen synthase gene expression in rat liver at the post-transcriptional level. J. Nutrition 125, 2457-2462.
• Nicholas J.G. Webster, Yan Kong, Donna Reichart, Brian Strauss, Martin Haas and B. Lynn Seely. (1995) Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Research 56, 2781-2788.
• Ze Huang, Noni L. Bodkin, Heidi K. Ortemeyer, Michael E. Zenilman, Nicholas J.G. Webster, Barbara C. Hansen, and Alan R. Schuldiner. (1996) Altered insulin receptor mRNA splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey: Analysis of controversy between monkey and human studies. J.Clin. Endocrinol. Metab. 81, 1552-1556.
• Nicholas J.G. Webster, Yan Kong, Prem Sharma, SaraswatiSukumar and B. Lynn Seely. (1997) Differential effects of Wilms' Tumor suppressor gene WT1 splice variants on the insulin receptor promoter. Biochemical and Molecular Medicine         62, 139-150.
• Atsushi Kosaki, James Nelson and Nicholas J.G. Webster. (1998) Identification of intron and exon sequences involved in alternative splicing of the insulin receptor pre-mRNA. J. Biol. Chem. 273, 10331-10337.
• Ayse G. Kayali, TetsuroHaruta, Aaron J. Morris, Peter Vollenweider, Jerrold M. Olefsky and Nicholas J.G. Webster. (1998) Association of the insulin receptor with phospholipase C-g (PLCg) in 3T3-L1 adipocytes suggests a role for PLCg in metabolic signaling by insulin. J. Biol. Chem. 273, 13808-13818.
• Jamie L. Resnik, Donna B. Reichart, Kim Huey, Nicholas J.G. Webster, and B. Lynn Seely. (1998) Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Research 58, 1159-1164.
• Nicholas J.G. Webster and Ze Huang. (1999) “Hormonal Regulation of Alternative Splicing” in Frontiers of Hormone Research: Post-transcriptional regulation of gene expression and its importance to the endocrine system, Editor Shern Chew, S. Karger AG, Basel, Switzerland, p1-18.
• Antje Zapf-Colby, Jens Eichhorn, Nicholas J.G. Webster and Jerrold M. Olefsky. (1999) Inhibition of PLC-g1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells. Oncogene 18, 4908-4919
• KyongSoo Park, Theodore P. Ciaraldi, Leslie Abrams-Carter, Sunder Mudalier, Svetlana E. Nikoulina, Nicholas J.G. Webster and Robert R. Henry. (2000) Metabolic effects of glycogen synthase gene inhibition in human skeletal muscle. Metabolism 49, 962-968
• Ayse G.  Kayali, Darrell A. Austin, and Nicholas J.G. Webster.  (2000) Stimulation of MAPK cascades by insulin and osmotic shock. Diabetes 49, 1783-1793.
• Jens Eichhorn, Ayse G. Kayali, Darrell A. Austin, and Nicholas J.G. Webster. (2001) Insulin activates Phospholipase C-g1 via a PI 3-kinase dependent mechanism in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 282, 615-620.
• Fujun Liu, Darrell A. Austin, Donna Dipaolo, Pamela L. Mellon, Jerrold M. Olefsky, and Nicholas J. G. Webster. (2002) GnRH activates ERK1/2 leading to the induction of c-fos and LHb protein expression in LbT2 cells. Mol. Endocrinol. 16, 419-434.
• Jens Eichhorn, Ayse G. Kayali, Darrell A. Austin, David W. Rose, and Nicholas J. G. Webster. (2002) Phospholipase C-g1 enzyme activity is required for insulin induced DNA synthesis. Endocrinology 143, 655-664.
• Vyacheslav V. Vasilyev, FlaviaPernasetti, Suzanne B. Rosenberg, Mark J. Barsoum, Darrell A. Austin, Nicholas J. G. Webster, and Pamela L. Mellon. (2002) Transcriptional activation of the ovine follicle stimulating hormone b gene by GnRH involves multiple signal transduction pathways. Endocrinology 143, 1651-1659
• Margarita Lorenzo, Teresa Teruel, Rosario Hernandez, Ayse G. Kayali, and Nicholas J. G. Webster. (2002) PLCg participates in insulin stimulation of glucose uptake through activation of PKCz in brown adipocytes. Exp. Cell Research 278, 146-157
• Vyacheslav V. Vasilyev, Mark A. Lawson, Donna DiPaolo, Nicholas J. G. Webster, and Pamela Mellon. (2002) Different signaling pathways control acute induction versus long-term repression of LHb transcription by GnRH. Endocrinology 143:3414-3426.
• B. Lynn Seely, GoliSamimi and Nicholas J. G. Webster (2002) Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo. BMC Cancer 2, 15-24)
• Ayse G. Kayali, Darrell A. Austin, and Nicholas J.G. Webster. (2002) Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology 143: 3884-3896.
• Fujun Liu, Isao Usui, LuiGuojing Evans, Darrell A. Austin, Pamela L. Mellon, Jerrold M. Olefsky, and Nicholas J. G. Webster. (2002) Involvement of both Gq/11 and Gs proteins in gonadotropin-releasing hormone receptor-mediated signaling in LbT2 cells. J. Biol. Chem. 277:32099-32108.
• Michael C. Pirrung, Kaapjoo Park, Yan Zhao, and Nicholas J. G. Webster. (2003) A selective insulin receptor modulator (SIRM): synthesis and signaling effects of Demethylasterriquinone B1. ChemBioChem.  4:379-385
• Sean D. Palacios, Kwang Pak, Ayse G. Kayali, Alexander Z. Rivkin, ChristophAletsee, AsaMelhus, Nicholas J. G. Webster, and Allen F. Ryan. (2002) Participation of Ras and ERK in the hyperplastic response of middle ear mucosa during bacterial otitis media. J. Inf. Disease. 186:1761-1769
• Fujun Liu, Darrell A. Austin, and Nicholas J.G. Webster.  (2003) GnRH-desensitized LbT2 gonadotropes are refractory to acute PKC, cAMP, and calcium-dependent signaling.  Endocrinology 144:4354-4365.
• Sean D. Palacios,  Alexander Z. Rivkin,  Ayse G. Kayali ,  ChristophAletsee, AsaMelhus, Nicholas J.G. Webster, Kwang Pak, Allen F. Ryan.  (2004) The role of p38-MAPK in middle ear mucosa hyperplasia during bacterial otitis media.  Infect Immun.  72:4662-4667
• Allen F. Ryan, Sean D. Palacios, Kwang Pak, Nicholas J.G. Webster.  (2004)  “Regulation of middle ear mucosal proliferation and apoptosis by receptor activation and signal transduction”in Recent Advances in Otitis Media with Effusion, Editors D. Lim et al. Kugler, Amsterdam,   pp. 112-114.
• Michael C. Pirrung, Yufa Liu, Michael Wedel, Diana K. Halstead, Zhitao Li, Darrell A. Austin, and Nicholas J.G. Webster.  (2005) Methyl scanning: syntheses of Demethylasterriquinone B1 derivatives and identification of sites of interaction with its receptor. J.Am.Chem.Soc. 127:4609-24
• Masayuki Furukawa, JorgEdmeyer,  Kwang Pak, Darrell A, Austin, Nicholas J.G. Webster, and Allen F. Ryan.  (2003) Regulation of bacterial otitis media-induced mucosal hyperplasia in rat middle ear epithelium by JNK.  (in preparation)
• Nicholas J. G. Webster, Lui-Guojing Evans, Matt Caples, Laura Erker, and Shern L. Chew.  (2004) Assembly of splicing complexes on exon 11 of the human insulin receptor gene does not correlate with splicing efficiency in-vitro.  BMC Molecular Biology 5:7-22
• Fujun Liu, Maribeth S. Ruiz, Darrell A. Austin and Nicholas J.G. Webster.  (2005) Constitutively active Gq impairs Gonadotropin Releasing Hormone-induced intracellular signaling and LH secretion.  Mol. Endocrinol. 19: 2074-2086
• Matsushima R, Harada N, Webster NJ, Tsutsumi YM, Nakaya Y. (2006) Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. J Biol Chem.  281:29719-29729
• HaoZhang, Janice S Bailey, DjurdjicaCoss, Bo Lin, RieTsutsumi, Mark A Lawson, Pamela L Mellon, and Nicholas J.G. Webster.  (2006)  Activin modulates the transcriptional response of LbT2 cells to GnRH and alters cellular proliferation. MolEndocrinol. 20:2909-2930
• Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. (2006) Interaction of musleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J.  25:4271-4283
• Chung WH, Pak K, Lin B, Webster N, Ryan AF. (2006)  A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J Assoc Res Otolaryngol. 7:373-82.
• Mark A. Lawson, RieTsutsumi, Hao Zhang, IndraniTalukdar, Brian K. Butler, Sharon J. Santos, Pamela L. Mellon, and Nicholas J.G. Webster.  (2007) Pulse sensitivity of the LHbpromoter is determined by a negative feedback loop involving Egr1 and Nab1/2.  Mol. Endocrinol 21:1175-1191
• Bo Lin, Michael C. Pirrung, Liu Deng, Zhitao Li, Yufa Liu and Nicholas J.G. Webster.  (2007) Neuroprotection by small molecule activators of the NGF receptor.  J.  Pharm. Exp. Thera. 322:59-69
• Michael C. Pirrung, Zhitao Li, Yufa Liu, Erika Hensley, AparnaTanksale, Bo Lin, Ashok Pai, and Nicholas J.G. Webster. (2007) Parallel Synthesis of Indolylquinones and Their Cell-based Insulin Mimicry.  J.Comb.Chem. 9(5):844-54
• Furukawa M, Ebmeyer J, Pak K, Austin DA, Melhus A, Webster NJ, Ryan AF.  (2007)  Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media. Infect Immun. 75:2562-71.
• Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster.  (2007) Identification of novel orally-available small molecule insulin mimetics. J.  Pharm. Exp. Thera. 323(2):579-85
• Min Lu, Qingbo Tang, Jerrold M. Olefsky, Pamela L. Mellon, and Nicholas J.G. Webster.  (2008) Adiponectin Activates AMPK and Decreases Luteinizing Hormone Secretion in LbT2 Gonadotropes.  Mol. Endocrinol. 22:579-585
• Michael C. Pirrung, Liu Deng, XinXiong, Bo Lin, and Nicholas J.G. Webster. (2008) Quinone Replacements for Orally Active Small Molecule Insulin Mimics. ChemBioChem 9:360-362
• Michelle Hernandez, AnkeLeichtle, Kwang Pak, JoergEbmeyer, Sara Euteneuer, MarrygorretObonyo, Donald G. Guiney, Nicholas J. Webster, David H. Broide, Allen F. Ryan and Stephen I Wasserman. (2008) MyD88 is required for the resolution of otitis media.  Journal of Infectious Diseases 198:1862-9
• Chandrasekar B, Boylston WH, Venkatachalam K, Webster NJ, Prabhu SD, Valente AJ. (2008) Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 283:24889-98
• Christopher S. Beevers, Long Chen, Lei Liu, Yan Luo, Nicholas J. G. Websterand Shile Huang. (2008)Curcumin disrupts the mammalian target of rapamycin-raptor complex.  Cancer Research 69:1000-8
• Webster NJ, Pirrung MC (2008) Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci. 2008 Dec 3;9Suppl 2:S1 PMCID:PMC2604901
• SupriyaSen, IndraniTalukdar, and Nicholas J.G. Webster.  (2009)  SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing.  Mol. Cell. Biol. 29:871-80 PMCID:PMC2630670
• AnkeLeichtle, Michelle Hernandez, Kwang Pak, Kenshi Yamasaki, Chun-Fang Cheng, Nicholas J. Webster, Allen F. Ryan and Stephen I Wasserman. (2009) TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media.  Innate Immunity 15:205-215 PMID: 19586996
• AnkeLeichtle, Michelle Hernandez, Kwang Pak, Nicholas J. Webster, Stephen I. Wasserman, Allen F. Ryan. (2009) The TRIF Toll-Like Receptor Adaptor Contributes to Pathogenesis and Recovery in Bacterial Otitis Media. BMC Immunol  10:45 PMCID: 2736931
• Tsutsumi R, Webster NJ (2009)GnRHpulsatility, the pituitary response and reproductive dysfunctionEndocr J. 56:729-37
• Nguyen, KA, Santos SJ, Webster NJG, Lawson MA.   (2010)  Modulation of GnRH-Induced ERK activation by DUSP-1 in LβT2 gonadotropes. Endocrinology 151:4882-93
• Sandip K. Datta, Kim Phung L. Nguyen, Jose M. Gonzalez-Navajas, Ivan Mihajlov, Paul A. Insel, Nicholas J. Webster, and EyalRaz.  (2010) Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. ProcNatlAcadSci107:10638-43PMID: 20479237
• RieTsutsumi, DevendraMistry and Nicholas J.G. Webster. (2010) cAMP signaling response to pulsatile GnRH in LbT2 gonadotrope cells. J. Biol. Chem. 285:20262-72PMCID: PMC2888439
• SupriyaSen, IndraniTalukdar, Ying Liu, Joseph Tam, Sita Reddy and Nicholas J.G. Webster (2010) Mbnl1 promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J. Biol. Chem. 285:25426-3
• Shweta Sharma, Prem M. Sharma, Devendra S. Mistry, R. Jeffery Chang, Jerrold M. Olefsky, Pamela L. Mellon, and Nicholas J.G. Webster.  (2011) PPARg regulates Gonadotropin Releasing Hormone signaling in LbT2 cells in vitro and pituitary gonadotrope function in vivo.  Biol. Repro. 84:466-475
• Joseph Godoy, Marin Nishimura and Nicholas J.G. Webster. (2011) Gonadotropin releasing hormone induces miR-132 and mir-212 to regulate cellular morphology and migration in immortalized LbT2 pituitary gonadotrope cells. Mol. Endocrinol. 25:810-20
• Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. (2011) Gonadotropin-Releasing Hormone Pulse Sensitivity of Follicle-Stimulating Hormone-{beta} Gene Is Mediated by Differential Expression of Positive Regulatory Activator Protein 1 Factors and Corepressors SKIL and TGIF1. MolEndocrinol. 25:1387-403
• Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. (2011) Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.ReprodToxicol. 32:85-92
• Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM. (2011) Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 17:618-22
• Nazari H, Khaleghian A, Takahashi A, Harada N, Webster NJ, Nakano M, Kishi K, Ebina Y, Nakaya Y. (2011) Cortactin, an Actin Binding Protein, Regulates GLUT4 Translocation via Actin Filament Remodeling.  Biochemistry (Mosc). 76:1262-9
• Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman SI, Ryan AF. (2011) The role of DNA sensing and innate immune receptor TLR9 in otitis media.Innate Immun. 18:3-13
• IndraniTalukdar, SupriyaSen, Rodolfo Urbano, James Thompson, John Yates III, and Nicholas J.G. Webster. (2011) hnRNP-A1 and hnRNP-F modulate the alternative splicing of exon 11 of the insulin receptor gene. PLOS One 6(11):e27869.
• Nazari H, Khaleghian A, Takahashi A, Harada N, Webster NJ, Nakano M, Kishi K, Ebina Y, Nakaya Y. (2011) Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling. Biochemistry (Mosc).76(11):1262-9.
• Ricaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA. (2012) Whole genome analysis of Leptospiralicerasiae provides insight into leptospiral evolution and pathogenicity.PLoSNegl Trop Dis. 6(10):e1853.
• Sen S, Jumaa H, Webster NJ. (2013) Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun. 4:1336.
• Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ. (2013) Endocrinology. 2013 154:2188-99.
• Schwaederle M, Parker BA, Schwab RB, Fanta PT, Boles SG, Daniels GA, Bazhenova LA, Subramanian R, Coutinho AC, Ojeda-Fournier H, Datnow B, Webster NJ, Lippman SM, Kurzrock R.Free Fatty Acids Induce Lhb mRNA but Suppress Fshb mRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice.(2014)Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 19:631-6.
• Sen S, Langiewicz M, Jumaa H, Webster NJ. (2014) Deletion of splicing factor SRSF3 in hepatocytes predisposes to hepatocellular carcinoma in mice.Hepatology. Aug 18. doi: 10.1002/hep.27380.
• Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, and Ellies LG. (2014) Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene (in press)

Invited talks:

• The Western Regional Meeting of the American Chemical Society, Sacramento, CA, 1984
• The Glaxo Research Institute, Geneva, Switzerland, 1988
• GeneLabs, Redwood City, CA, 1988
• Division of Endocrinology and Metabolism, University of California, San Diego, CA, 1988
• IV International Symposium on Insulin receptor and Insulin Action, Verona, Italy, May, 1990
• 3rd International Symposium on Endocrinology under 35, Ravenna, Italy, 1992.
• Western Section, American Federation for Clinical Research, “Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer”, Carmel, CA, February, 1996
• V International Symposium on Insulin Receptors and Insulin Action, “A possible involvement for phospholipase Cg in insulin action?” Copenhagen, Denmark, May, 1996
• 21st Meeting of the International Association for Breast Cancer Research, “Functional assessment of IGF-I and insulin receptors in breast cancer”, Paris, France, August, 1996
• Gastroenterology Grand Rounds, “Role of phospholipase C in insulin signaling”, University of California, San Diego, CA, 1997
• 16th International Diabetes Federation Congress, “Is phospholipase Cg involved in insulin action in 3T3-L1 adipocytes?” Helsinki, Finland, May 1997
• 4th European Congress of Endocrinology, “Alternative Splicing of the insulin receptor gene”, Seville, Spain, May 1998
• Hematology/Oncology Grand Rounds, “The IGF-I receptor and breast cancer”, University of California, San Diego, CA, 1998
• St. Bartholomew’s Hospital Endocrine Club,  “The IGF-I receptor and breast cancer”, London, UK, December 1999
• Departamento de Bioquimica y Biologia Molecular, Universidad Complutense de Madrid, “Insulin signaling: a myriad of pathways”, Madrid, Spain, February 2000.
• Institute of Cell Signaling, Medical School, University of Nottingham, “The Insulin Receptor: a myriad of signaling pathways”, Nottingham, UK, April 2000.
• St. Bartholomew’s Hospital Endocrine Club,  “Alternative splicing of the insulin receptor”, London, UK, April, 2000
• Department of Clinical Biochemistry, University of Cambridge, “The insulin receptor: regulation and signaling”, Cambridge, UK, April 2000.
• Institute de Genetiqueet de BiologieMoleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, “Alternative Splicing of the Insulin Receptor”, Strasbourg, France, April 2000.
• Neuroendocrine-Pituitary Function Focus Group, Specialized Cooperative Centers Program in Reproduction Research, NICHD, NIH, “GnRH activates MAPK and induces c-fos and LHb protein expression in LbT2 cells”, San Diego, CA, January 2001.
• Specialized Cooperative Centers Program in Reproduction Research, NICHD, NIH, “GnRH activates MAPK and induces c-fos and LHb protein expression in LbT2 cells”, Bethesda, MD, May 2001.
• 4th International Conference on Insulin Action and Insulin Resistance: New Targets for Therapy, “Asterriquinone based Insulin-Mimetics”, Beijing, China, May, 2002
• Invited Seminar “Asterriquinone-based Insulin Mimetics”,Pfizer Research Labs, Groton CT October 2002
• Invited Seminar “RNAi: A technical seminar on how to knock-out your favorite gene in your favorite cells”, UCSD Postdoctoral Scholars Association, December 2002
• Neuroendocrine-Pituitary Function Focus Group Specialized Cooperative Centers Program in Reproduction Research, NICHD, NIH, “Adiponectin at the crossroads of Metabolism and Reproduction”, Houston, TX, May, 2006
• 6th International Conference on Insulin Action and Insulin Resistance: New Targets for Therapy “Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity”, Arusha, Tanzania, November 2006
• Neuroendocrine-Pituitary Function Focus Group, Specialized Cooperative Centers Program in Reproduction Research, NICHD, NIH, “Adiponectin at the crossroads of Metabolism and Reproduction”, San Diego, CA, February, 2007
• Specialized Cooperative Centers Program in Reproduction Research, NICHD, NIH, “Pulse regulation of the LHb promoter”, Portland, OR, May, 2007
• Invited seminar at University of Virginia: “The impact of metabolism on reproduction” Charlottesville, 2007
• Seminar speaker at the Society for the Study of Reproduction: “Gonadotrope Responses to Pulsatile GnRH” Hawaii, 2008
• Seminar speaker at The Endocrine Society Annual Meeting: “GnRH Pulses & Gene Expression in the Gonadotrope” San Francisco, 2008
• 7th International Conference on Insulin Action and Insulin Resistance: New Targets for Therapy “Alternative Splicing of the Insulin Receptor Gene”, New Delhi, India, 2009
• Visiting Scientist,  Japanese Society for the Promotion of Science, September 2009.
• Plenary lecture at the Japanese Pituitary Society: “Pulse regulation of pituitary gonadotropin genes” Misawa City, Japan 2009
• Invited seminar on “Integration of signaling by the pituitary gonadotrope: Interaction of metabolism and reproduction” Nippon Medical School, Tokyo, Japan 2009
• Invited seminar on “Integration of signaling by the pituitary gonadotrope” University of Tokyo, Tokyo, Japan 2009
• Invited seminar on “Integration of signaling by the pituitary gonadotrope: Interaction of metabolism and reproduction” University of Tokushima, Japan 2009
• Lecture at a microarray workshop at the Japanese Society for Reproduction and Development meeting: “Pulse regulation of pituitary gonadotropin genes: Application of DNA microarrays to neuroendocrine research” Nara, Japan 2009
• Invited seminar at Northwestern University: “Integration of signaling by the pituitary gonadotrope” Evanston, 2010
• Invited talk to the Oncology Research Group: “Genomics Resources at UCSD” Moores Cancer Center, UCSD, 2012
• PRISM Lecture “SRSF3 and Alternative Splicing in Hepatocyte Differentiation and Metabolism”, Department of Medicine, UCSD, 2013